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https://www.readbyqxmd.com/read/28323841/detection-of-crossed-cerebellar-diaschisis-in-hyperacute-ischemic-stroke-using-arterial-spin-labeled-mr-imaging
#1
Koung Mi Kang, Chul-Ho Sohn, Seung Hong Choi, Keun-Hwa Jung, Roh-Eul Yoo, Tae Jin Yun, Ji-Hoon Kim, Sun-Won Park
BACKGROUND AND PURPOSE: Arterial spin-labeling (ASL) was recently introduced as a noninvasive method to evaluate cerebral hemodynamics. The purposes of this study were to assess the ability of ASL imaging to detect crossed cerebellar diaschisis (CCD) in patients with their first unilateral supratentorial hyperacute stroke and to identify imaging or clinical factors significantly associated with CCD. MATERIALS AND METHODS: We reviewed 204 consecutive patients who underwent MRI less than 8 hours after the onset of stroke symptoms...
2017: PloS One
https://www.readbyqxmd.com/read/28319118/functional-mri-for-characterization-of-renal-perfusion-impairment-and-edema-formation-due-to-acute-kidney-injury-in-different-mouse-strains
#2
Susanne Tewes, Faikah Gueler, Rongjun Chen, Marcel Gutberlet, Mi-Sun Jang, Martin Meier, Michael Mengel, Dagmar Hartung, Frank Wacker, Song Rong, Katja Hueper
PURPOSE: The purpose was to characterize acute kidney injury (AKI) in C57BL/6 (B6)- and 129/Sv (Sv)-mice by noninvasive measurement of renal perfusion and tissue edema using functional MRI. METHODS: Different severities of AKI were induced in B6- and Sv-mice by renal ischemia reperfusion injury (IRI). Unilateral clamping of the renal pedicle for 35 min (moderate AKI) or 45 min (severe AKI) was done. MRI (7-Tesla) was performed 1, 7 and 28 days after surgery using a flow alternating inversion recovery (FAIR) arterial spin labeling (ASL) sequence...
2017: PloS One
https://www.readbyqxmd.com/read/28318434/perceived-barriers-to-following-dietary-recommendations-in-hypertensive-patients
#3
Reza Mahdavi, Azadeh Bagheri Asl, Mohammad Asghari Jafar Abadi, Nazli Namazi
OBJECTIVE: Hypertension (HTN) is one of the most important public health problems in the world. Lifestyle modification including dietary changes such as following the Dietary to Stop Hypertension (DASH) plan is the first step to control HTN. The aim of the present study was to identify perceived barriers to following dietary recommendations in hypertensive patients in Zanjan, Iran. MATERIALS AND METHODS: In this cross-sectional study, 200 outpatients (161 women, 39 men) with essential HTN (systolic blood pressure [SBP] ≥ 140 mmHg and diastolic blood pressure [DBP] ≥ 90 mmHg) were recruited from August to November 2012...
March 20, 2017: Journal of the American College of Nutrition
https://www.readbyqxmd.com/read/28303317/evaluation-of-the-applicability-of-territorial-arterial-spin-labeling-in-meningiomas-for-presurgical-assessments-compared-with-3-dimensional-time-of-flight-magnetic-resonance-angiography
#4
Yiping Lu, Shihai Luan, Li Liu, Ji Xiong, Jianbo Wen, Jianxun Qu, Daoying Geng, Bo Yin
OBJECTIVES: To prospectively evaluate the application of territorial arterial spin labelling (t-ASL) in comparison with unenhanced three-dimensional time-of-flight magnetic resonance angiography (3D-TOF-MRA) in the identification of the feeding vasculature of meningiomas. METHODS: Thirty consecutive patients with suspected meningiomas underwent conventional MR imaging, unenhanced 3D-TOF-MRA and t-ASL scanning. Four experienced neuro-radiologists assessed the feeding vessels with different techniques separately...
March 16, 2017: European Radiology
https://www.readbyqxmd.com/read/28301491/the-performance-of-mr-perfusion-weighted-imaging-for-the-differentiation-of-high-grade-glioma-from-primary-central-nervous-system-lymphoma-a-systematic-review-and-meta-analysis
#5
Weilin Xu, Qun Wang, Anwen Shao, Bainan Xu, Jianmin Zhang
It is always a great challenge to distinguish high-grade glioma (HGG) from primary central nervous system lymphoma (PCNSL). We conducted a meta-analysis to assess the performance of MR perfusion-weighted imaging (PWI) in differentiating HGG from PCNSL. The heterogeneity and threshold effect were evaluated, and the sensitivity (SEN), specificity (SPE) and areas under summary receiver operating characteristic curve (SROC) were calculated. Fourteen studies with a total of 598 participants were included in this meta-analysis...
2017: PloS One
https://www.readbyqxmd.com/read/28298978/can-galvanic-skin-conductance-be-used-as-an-objective-indicator-of-children-s-anxiety-in-the-dental-setting
#6
Ebrahim Najafpour, Naser Asl-Aminabadi, Sara Nuroloyuni, Zahra Jamali, Sajjad Shirazi
BACKGROUND: Assessment of procedural distress is essential at assisting children during invasive dental treatments. This study aimed to determine the validity and reliability of galvanic skin response as a measure for assessment of dental anxiety in children. MATERIAL AND METHODS: 151 children, aged 5-7 years, participated in this study. Similar dental treatments were rendered to all subjects. At the beginning and end of the session, modified child dental anxiety scale (MCDAS), clinical anxiety rating scale (CARS) and galvanic skin response (GSR) were used to determine children's anxiety...
March 2017: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/28298974/zeolite-silver-zinc-nanoparticles-biocompatibility-and-their-effect-on-the-compressive-strength-of-mineral-trioxide-aggregate
#7
Mohammad Samiei, Negin Ghasemi, Naser Asl-Aminabadi, Baharak Divband, Yasamin Golparvar-Dashti, Sajjad Shirazi
BACKGROUND: This study was carried out to evaluate the biocompatibility of zeolite-silver-zinc (Ze-Ag-Zn) nanoparticles and their effect on the compressive strength of Mineral Trioxide Aggregate (MTA). MATERIAL AND METHODS: Biocompatibility was evaluated by an MTT assay on the pulmonary adenocarcinoma cells with 0.05, 0.1, 0.25, 0.5, 1 and 5 mg/mL concentrations of Ze-Ag-Zn. For compressive strength test, four groups containing 15 stainless-steel cylinders with an internal diameter of 4 and a height of 6 mm were prepared and MTA (groups 1 and 2) or MTA + 2% Ze-Ag-Zn (groups 3 and 4) were placed in the cylinders...
March 2017: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/28298568/comparison-of-disease-characteristics-organ-damage-and-survival-in-patients-with-juvenile-onset-and-adult-onset-systemic-lupus-erythematosus-in-a-combined-cohort-from-2-tertiary-centers-in-turkey
#8
Bahar Artim-Esen, Sezgin Şahin, Erhan Çene, Yasemin Şahinkaya, Kenan Barut, Amra Adrovic, Yasemin Özlük, Işın Kılıçaslan, Ahmet Omma, Ahmet Gül, Lale Öcal, Özgür Kasapçopur, Murat İnanç
OBJECTIVE: Age at onset has been shown to affect the clinical course and outcome of systemic lupus erythematosus (SLE). Herein, we aimed to define the differences in clinical characteristics, organ damage, and survival between patients with juvenile-onset (jSLE) and adult-onset SLE (aSLE). METHODS: For the study, 719 patients (76.9%) with aSLE and 216 (23.1%) with jSLE were examined. Comparisons between the groups were made for demographic characteristics, clinical features, autoantibody profiles, damage, and survival rates...
March 15, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28294455/integration-of-arterial-spin-labeling-into-stereotactic-radiosurgery-planning-of-cerebral-arteriovenous-malformations
#9
Onur Ozyurt, Alp Dincer, Mehmet Erdem Yildiz, Selcuk Peker, Meltem Yilmaz, Meric Sengoz, Cengizhan Ozturk
PURPOSE: To test whether the combined use of 4D arterial spin labeling angiography (4D ASL) and contrast-enhanced magnetic resonance angiography (4D CE-MRA) can work as a prospective alternative to digital subtraction angiography (DSA) for the delineation of the arteriovenous malformation (AVM) nidus in stereotactic radiosurgery (SRS) planning. MATERIALS AND METHODS: A custom 4D ASL sequence and a proof-of-concept software tool to integrate 4D ASL data to SRS planning were implemented...
March 10, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28294401/endothelial-progenitor-cell-mobilization-in-preterm-infants-with-sepsis-is-associated-with-improved-survival
#10
Vahid Siavashi, Simin Asadian, Masoud Taheri-Asl, Samaneh Keshavarz, Mohamad Zamani-Ahmadmahmudi, Seyed Mahdi Nassiri
Microvascular dysfunction plays a key role in the pathology of sepsis, leading to multi-organ failure and death. Circulating endothelial progenitor cells (cEPCs) are critically involved in the maintenance of the vascular homeostasis in both physiological and pathological contexts. In this study, concentration of cEPCs in preterm infants with sepsis was determined to recognize whether the EPC mobilization would affect the clinical outcome of infantile sepsis. 133 preterm infants (81 with sepsis and 52 without sepsis) were enrolled in this study...
March 10, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28292973/evaluation-of-functional-characteristics-of-4-oscillatory-positive-pressure-devices-in-a-simulated-cystic-fibrosis-model
#11
Hillary Van Fleet, Diane K Dunn, Neil L McNinch, Teresa A Volsko
BACKGROUND: Oscillatory positive expiratory pressure (OPEP) is an airway clearance therapy that delivers positive pressure and air-flow oscillations during exhalation. This study described functional characteristic differences of 4 OPEP devices during an active exhalation in a simulated model. We hypothesized peak pressure (Ppeak), positive expiratory pressure (PEP), oscillatory frequency (f), and pressure amplitude will differ, depending upon the device used, device resistance setting, and time (repeated consecutive active exhalations through the device)...
March 14, 2017: Respiratory Care
https://www.readbyqxmd.com/read/28292652/synthesis-and-toxicity-assessment-of-3-oxobutanamides-against-human-lymphocytes-and-isolated-mitochondria
#12
Nima Razzaghi-Asl, Enaytollah Seydi, Radin Alikhani, Saba Rezvani, Ramin Miri, Ahmad Salimi
To reduce costly late-phase compound scrubbing, there has been an increased focus on assessing compounds within in vitro assays that predict properties of human safety liabilities, before preclinical in vivo studies. The aim of our study was to answer the questions that whether the toxicity risk of a series of 3-oxobutanamide derivatives could be predicted by using of human lymphocytes and their isolated mitochondria. Using biochemical and flow cytometry assessments, we demonstrated that exposure of lymphocytes and isolated mitochondria to five 3-oxobutanamide derivatives (1-5) did not exhibit remarkable toxicity at low concentrations (50-500μM) but toxicity could be observed at high concentrations (1000 and 2000μM), particularly for N-(5-(4-bromophenyl)-3-isoxazolyl)-3-oxobutanamide (4) and N-(2-benzothiazolyl)-3-oxo butanamide (5)...
March 7, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28291816/identification-of-cerebral-perfusion-using-arterial-spin-labeling-in-patients-with-seizures-in-acute-settings
#13
Roh-Eul Yoo, Tae Jin Yun, Byung-Woo Yoon, Sang Kun Lee, Soon-Tae Lee, Koung Mi Kang, Seung Hong Choi, Ji-Hoon Kim, Chul-Ho Sohn, Sun-Won Park, Moon Hee Han
This study aimed to explore the utility of arterial spin labeling perfusion-weighted imaging (ASL-PWI) in patients with suspected seizures in acute settings. A total of 164 patients who underwent ASL-PWI for suspected seizures in acute settings (with final diagnoses of seizure [n = 129], poststroke seizure [n = 18], and seizure mimickers [n = 17]), were included in this retrospective study. Perfusion abnormality was analyzed for: (1) pattern, (2) multifocality, and (3) atypical distribution against vascular territories...
2017: PloS One
https://www.readbyqxmd.com/read/28289611/comparison-of-characteristics-of-human-amniotic-membrane-and-human-adipose-tissue-derived-mesenchymal-stem-cells
#14
Khadijeh Dizaji Asl, Hajar Shafaei, Jafar Soleimani Rad, Hojjat Ollah Nozad
BACKGROUND: Mesenchymal stem cells (MSCs) are ideal candidates for treatment of diseases. Amniotic membranes are an inexpensive source of MSCs (AM-MSC) without any donor site morbidity in cell therapy. Adipose tissue derived stem cells (ASCs) are also suitable cells for cell therapy. There is discrepancy in CD271 expression among MSCs from different sources. In this study, the characteristics of AM-MSC and ASCs and CD271 expression were compared. METHODS: Adult adipose tissue samples were obtained from patients undergoing elective surgical procedure, and samples of amniotic membrane were collected immediately after caesarean operation...
January 2017: World Journal of Plastic Surgery
https://www.readbyqxmd.com/read/28286810/epidemiology-and-related-risk-factors-of-preterm-labor-as-an-obstetrics-emergency
#15
Ali Asghar Halimi Asl, Saeed Safari, Mohsen Parvareshi Hamrah
INTRODUCTION: Preterm birth is still a major health problem throughout the world, which results in 75% of neonatal mortality. Preterm labor not only inflicts financial and emotional distress, it may also lead to permanent disability. The present study was conducted to determine the related risk factors and preventive measures of preterm labor. METHODS: This retrospective cross-sectional study assessed all preterm labors, as well as an equal number of term labors, during seven years, at an educational hospital...
2017: Emergency (Tehran, Iran)
https://www.readbyqxmd.com/read/28281146/influence-of-the-cardiac-cycle-on-pcasl-cardiac-triggering-of-the-end-of-labeling
#16
Jasper Verbree, Matthias J P van Osch
OBJECTIVE: In arterial spin labeling (ASL), the cardiac cycle might adversely influence signal-stability by varying the amount of label created, labeling efficiency and/or transport times. Due to the long labeling duration in pseudo-Continuous ASL (pCASL), the blood labeled last contributes most to the ASLsignal. The present study investigated, using numerical simulations and in vivo experiments, the effect of the cardiac cycle on pCASL, thereby focusing on the end-of-labeling. MATERIALS AND METHODS: In the in vivo experiments the end-of-labeling was timed to a specific cardiac phase while a long labeling duration of >7 s was used to isolate the influence of the lastly labeled spins on ASL-signal stability...
March 9, 2017: Magma
https://www.readbyqxmd.com/read/28277457/advanced-mri-measures-of-cerebral-perfusion-and-their-clinical-applications
#17
Bryan Lanzman, Jeremy J Heit
Cerebral blood flow measurement by magnetic resonance imaging perfusion (MRP) techniques is broadly applied to patients with acute ischemic stroke, vasospasm following aneurysmal subarachnoid hemorrhage, chronic arterial steno-occlusive disease, cervical atherosclerotic disease, and primary brain neoplasms. MRP may be performed using an exogenous tracer, most commonly gadolinium-based intravenous contrast, or an endogenous tracer, such as arterial spin labeling (ASL) or intravoxel incoherent motion (IVIM). Here, we review the technical basis of commonly performed MRP techniques, the interpretation of MRP imaging maps, and how MRP provides valuable clinical information in the triage of patients with cerebral disease...
March 8, 2017: Topics in Magnetic Resonance Imaging: TMRI
https://www.readbyqxmd.com/read/28271290/arterial-spin-labelling-detects-posterior-cortical-hypoperfusion-in-non-demented-patients-with-parkinson-s-disease
#18
Zoe Joanna Syrimi, Lubomir Vojtisek, Ilona Eliasova, Jana Viskova, Alena Svatkova, Jiri Vanicek, Irena Rektorova
While previous studies suggested that perfusion abnormalities in Parkinson's disease (PD) are driven by dementia, our study aimed to identify perfusion underpinning of cognitive alteration in non-demented PD patients. Cerebral blood flow was measured using arterial spin labelling (ASL) in 28 PD patients (age 65 years ± 9.9 SD) and 16 age-matched healthy controls (HC) (age 65 years ± 7.8 SD), who also underwent neurological and cognitive testing. The 3D pseudocontinuous ASL and T2-weighted scans from 22 PD patients and 16 HC were analysed in a voxel-wise manner using SPM8 software...
March 7, 2017: Journal of Neural Transmission
https://www.readbyqxmd.com/read/28266894/aspects-based-reperfusion-status-on-arterial-spin-labeling-is-associated-with-clinical-outcome-in-acute-ischemic-stroke-patients
#19
Songlin Yu, Samantha J Ma, David S Liebeskind, Dandan Yu, Ning Li, Xin J Qiao, Xingfeng Shao, Lirong Yan, Bryan Yoo, Fabien Scalzo, Jason D Hinman, Latisha K Sharma, Neal Rao, Reza Jahan, Satoshi Tateshima, Gary R Duckwiler, Jeffrey L Saver, Noriko Salamon, Danny Jj Wang
The purpose of this study was to develop and evaluate a scoring system for assessing reperfusion status based on arterial spin labeled (ASL) perfusion MRI in acute ischemic stroke (AIS) patients receiving thrombolysis and/or endovascular treatment. Pseudo-continuous ASL with background suppressed 3D GRASE was acquired along with DWI in 90 patients within 24 h post-treatment. An automatic reperfusion scoring system (auto-RPS) was devised based on the Alberta Stroke Program Early CT Score (ASPECTS) template, and compared with manual RPS and DWI-ASPECTS...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28259722/oxytocin-mitigated-the-depressive-like-behaviors-of-maternal-separation-stress-through-modulating-mitochondrial-function-and-neuroinflammation
#20
Hossein Amini-Khoei, Ali Mohammadi-Asl, Shayan Amiri, Mir-Jamal Hosseini, Majid Momeny, Mahsa Hassanipour, Mojgan Rastegar, Arya Haj-Mirzaian, Arvin Haj Mirzaian, Hossein Sanjarimoghaddam, Shahram Ejtemaei Mehr, Ahmad Reza Dehpour
Mother-infant contact has a critical role on brain development and behavior. Experiencing early-life adversities (such as maternal separation stress or MS in rodents) results in adaptations of neurotransmission systems, which may subsequently increase the risk of depression symptoms later in life. In this study, we show that Oxytocin (OT) exerted antioxidant and anti-inflammatory properties. Previous studies indicate that neuroinflammation and mitochondrial dysfunction are associated with the pathophysiology of depression...
March 1, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
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