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https://www.readbyqxmd.com/read/28544530/denatonium-induced-sinonasal-bacterial-killing-may-play-a-role-in-chronic-rhinosinusitis-outcomes
#1
Ryan M Carey, Alan D Workman, Kyle M Hatten, Adam P Siebert, Steven G Brooks, Bei Chen, Nithin D Adappa, James N Palmer, David W Kennedy, Robert J Lee, Noam A Cohen
BACKGROUND: Sinonasal bitter taste receptors (T2Rs) contribute to upper airway innate immunity and correlate with chronic rhinosinusitis (CRS) clinical outcomes. A subset of T2Rs expressed on sinonasal solitary chemosensory cells (SCCs) are activated by denatonium, resulting in a calcium-mediated secretion of bactericidal antimicrobial peptides (AMPs) in neighboring ciliated epithelial cells. We hypothesized that there is patient variability in the amount of bacterial killing induced by different concentrations of denatonium and that the differences correlate with CRS clinical outcomes...
May 23, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/28543885/dce-mri-prediction-of-survival-time-for-patients-with-glioblastoma-multiforme-using-an-adaptive-neuro-fuzzy-based-model-and-nested-model-selection-technique
#2
Azimeh N V Dehkordi, Alireza Kamali-Asl, Ning Wen, Tom Mikkelsen, Indrin J Chetty, Hassan Bagher-Ebadian
This pilot study investigates the construction of an Adaptive Neuro-Fuzzy Inference System (ANFIS) for the prediction of the survival time of patients with glioblastoma multiforme (GBM). ANFIS is trained by the pharmacokinetic (PK) parameters estimated by the model selection (MS) technique in dynamic contrast enhanced-magnetic resonance imaging (DCE-MRI) data analysis, and patient age. DCE-MRI investigations of 33 treatment-naïve patients with GBM were studied. Using the modified Tofts model and MS technique, the following physiologically nested models were constructed: Model 1, no vascular leakage (normal tissue); Model 2, leakage without efflux; Model 3, leakage with bidirectional exchange (influx and efflux)...
May 25, 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/28541060/metacognition-and-cognition-in-inpatient-mct-and-cbt-for-comorbid-anxiety-disorders-a-study-of-within-person-effects
#3
Sverre Urnes Johnson, Asle Hoffart, Hans M Nordahl, Pål G Ulvenes, KariAnne Vrabel, Bruce E Wampold
Psychotherapists have long questioned what mediating processes are linked to outcome of psychotherapy. Few studies examining this question have assessed within-person changes in the process outcome relationship over time. The present study examined changes in cognition and metacognition over the course of therapy using a dataset from a randomized controlled trial comparing Metacognitive therapy (MCT) and Cognitive-behavioral therapy (CBT). The sample included 74 patients measured on process and symptom instruments weekly throughout therapy...
May 25, 2017: Journal of Counseling Psychology
https://www.readbyqxmd.com/read/28537106/vasoreactivity-in-cadasil-comparison-to-structural-mri-and-neuropsychology
#4
Fiona C Moreton, Breda Cullen, Christian Delles, Celestine Santosh, Rosario L Gonzalez, Krishna Dani, Keith W Muir
Impaired cerebrovascular reactivity precedes histological and clinical evidence of CADASIL in animal models. We aimed to more fully characterise peripheral and cerebral vascular function and reactivity in a cohort of adult CADASIL patients, and explore the associations of these with conventional clinical, imaging and neuropsychological measures. A total of 22 adults with CADASIL gave informed consent to participate in an exploratory study of vascular function in CADASIL. Clinical assessment, comprehensive vascular assessment, MRI and neuropsychological testing were conducted...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28536472/quantifying-the-area-at-risk-of-myocardial-infarction-in-vivo-using-arterial-spin-labeling-cardiac-magnetic-resonance
#5
Rachel K Dongworth, Adrienne E Campbell-Washburn, Hector A Cabrera-Fuentes, Heerajnarain Bulluck, Thomas Roberts, Anthony N Price, Sauri Hernández-Reséndiz, Roger J Ordidge, David L Thomas, Derek M Yellon, Mark F Lythgoe, Derek J Hausenloy
T2-weighted cardiovascular magnetic resonance (T2-CMR) of myocardial edema can quantify the area-at-risk (AAR) following acute myocardial infarction (AMI), and has been used to assess myocardial salvage by new cardioprotective therapies. However, some of these therapies may reduce edema, leading to an underestimation of the AAR by T2-CMR. Here, we investigated arterial spin labeling (ASL) perfusion CMR as a novel approach to quantify the AAR following AMI. Adult B6sv129-mice were subjected to in vivo left coronary artery ligation for 30 minutes followed by 72 hours reperfusion...
May 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28532146/calcium-iron-and-zinc-bioaccessibilities-of-australian-sweet-lupin-lupinus-angustifolius-l-cultivars
#6
Weeraya Karnpanit, Ranil Coorey, Jon Clements, Wenika Benjapong, Vijay Jayasena
The study aimed to determine the effect of cultivar and dehulling on calcium, iron and zinc bioaccessibilities of Australian sweet lupin (ASL). Ten ASL cultivars grown in 2011, 2012 and 2013 in Western Australia were used for the study. The bioaccessibilities of calcium, iron and zinc in whole seed and dehulled lupin samples were determined using a dialysability method. Cultivar had significant effects on calcium, iron and zinc contents and their bioaccessibilities. The average bioaccessibilities of 6% for calcium, 17% for iron and 9 % for zinc were found for whole seeds...
May 22, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28528845/comparison-of-3-and-7-t-asl-techniques-for-concurrent-functional-perfusion-and-bold-studies
#7
Dimo Ivanov, Anna Gardumi, Roy Am Haast, Josef Pfeuffer, Benedikt A Poser, Kâmil Uludağ
Arterial spin labeling (ASL) is the primary non-invasive MRI approach to measure baseline cerebral blood flow (CBF) in healthy subjects and patients. ASL also allows concurrent functional BOLD signal and CBF measurements, but the latter typically suffers from low contrast-to-noise (CNR) ratio. Ultra-high-field imaging significantly boosts BOLD signal CNR. However, it is contested whether also CBF CNR benefits from increasing magnetic field strength, especially given that technical challenges related to field inhomogeneities and power deposition constraints exist...
May 18, 2017: NeuroImage
https://www.readbyqxmd.com/read/28524825/chinese-systemic-lupus-erythematosus-treatment-and-research-group-registry-ix-clinical-features-and-survival-of-childhood-onset-systemic-lupus-erythematosus-in-china
#8
Chan-Yuan Wu, Cai-Feng Li, Qing-Jun Wu, Jian-Hua Xu, Lin-Di Jiang, Lu Gong, Feng-Qi Wu, Jie-Ruo Gu, Jiu-Liang Zhao, Meng-Tao Li, Yan Zhao, Xiao-Feng Zeng
BACKGROUND: Approximately 15-20% cases of systemic lupus erythematosus (SLE) are diagnosed in children. There have been a few studies reporting the epidemiological data of pediatric-onset SLE (cSLE) in China, neither comparing the differences between cSLE and adult-onset SLE (aSLE). The aim of this study was to describe the impact of age of onset on clinical features and survival in cSLE patients in China based on the Chinese SLE Treatment and Research group (CSTAR) database. METHODS: We made a prospective study of 225 cSLE patients (aged Results: The mean age of cSLE patients was 12...
June 5, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28516482/multiple-boli-arterial-spin-labeling-for-high-signal-to-noise-rodent-brain-perfusion-imaging
#9
Antoine Vallatos, Lesley Gilmour, Anthony J Chalmers, William M Holmes
PURPOSE: A systematic method is proposed for optimizing a promising preclinical arterial spin labeling (ASL) sequence based on the use of a train of adiabatic radiofrequency pulses labeling successive boli of blood water. METHODS: The sequence optimization is performed and evaluated using brain imaging experiments in mice and in rats. It involves the investigation of several parameters, ranging from the number of adiabatic pulses and labeling duration to the properties of the adiabatic hyperbolic secant pulses (ie, amplitude and frequency modulation)...
May 17, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28513057/systemic-inflammation-and-alterations-to-cerebral-blood-flow-in-obstructive-sleep-apnea
#10
Hsiu-Ling Chen, Hsin-Ching Lin, Cheng-Hsien Lu, Pei-Chin Chen, Chih-Cheng Huang, Kun-Hsien Chou, Mao-Chang Su, Michael Friedman, Yi-Wen Chen, Wei-Che Lin
Systemic inflammation and alterations to regional cerebral blood flow (CBF) have been reported previously in obstructive sleep apnea (OSA). This study utilized arterial spin labelling (ASL) perfusion magnetic resonance imaging (MRI) to evaluate CBF in OSA patients and determine its relationship with systemic inflammation. Twenty male patients with moderate and severe OSA [apnea-hypopnea index (AHI) >15] and 16 healthy male volunteers (AHI <5) were recruited. Early- or late-phase changes in leucocyte apoptosis and its subsets were determined by flow cytometry...
May 17, 2017: Journal of Sleep Research
https://www.readbyqxmd.com/read/28507896/intraoperative-resection-control-using-arterial-spin-labeling-proof-of-concept-reproducibility-of-data-and-initial-results
#11
Thomas Lindner, Hajrullah Ahmeti, Isabel Lübbing, Michael Helle, Olav Jansen, Michael Synowitz, Stephan Ulmer
OBJECTIVES: Intraoperative magnetic resonance imaging is a unique tool for visualizing structures during resection and/or for updating any kind of neuronavigation that might be hampered as a result of brain shift during surgery. Advanced MRI techniques such as perfusion-weighted imaging have already proven to be important in the initial diagnosis preoperatively, but can also help to differentiate between tumor and surgically induced changes intraoperatively. Commonly used methods to visualize brain perfusion include contrast agent administration and are therefore somewhat limited...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28506213/voxel-wise-correlations-between-cognition-and-cerebral-blood-flow-using-arterial-spin-labeled-perfusion-mri-in-patients-with-alzheimer-s-disease-a-cross-sectional-study
#12
Tomohiro Kaneta, Omi Katsuse, Takamasa Hirano, Matsuyoshi Ogawa, Ayako Shihikura-Hino, Keisuke Yoshida, Toshinari Odawara, Yoshio Hirayasu, Tomio Inoue
BACKGROUND: To analyze voxel-wise correlation between cerebral blood flow (CBF) measured using ASL-MRI and cognition in patients with Alzheimer's disease (AD). METHODS: Forty-one patients diagnosed with AD or mild cognitive impairment due to AD were recruited for this study. CBF images were obtained using ASL-MRI (n = 41) with a post-labeling delay (PLD) of 1.5 and 2.5 s (PLD1.5 and PLD2.5, respectively) using a 3 T scanner, in addition to brain perfusion SPECT with N-isopropyl-4-[I-123]iodoamphetamine (n = 28)...
May 15, 2017: BMC Neurology
https://www.readbyqxmd.com/read/28500300/alterations-of-cerebral-perfusion-in-asymptomatic-internal-carotid-artery-steno-occlusive-disease
#13
Ya-Fang Chen, Sung-Chun Tang, Wen-Chau Wu, Hsien-Li Kao, Yen-Shu Kuo, Shun-Chung Yang
Patients with asymptomatic occlusion in the internal carotid arteries (ICA) have been shown to have a better preserved hemodynamic status of the brain as compared to patients with symptoms. This study was aimed to explore the cerebral perfusion alterations in asymptomatic patients using multi-parametric arterial spin-labeling (ASL) magnetic resonance (MR) imaging. Forty-two patients diagnosed with asymptomatic ICA stenosis/occlusion were prospectively included and divided into high-grade (ultrasonographic stenosis ≥70%, N = 20) and low-grade groups (N = 22)...
May 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28493333/treadmill-exercise-attenuates-3-4-methylenedioxymethamphetamine-induced-memory-impairment-through-a-decrease-apoptosis-in-male-rat-hippocampus
#14
Alireza Gharebaghi, Iraj Amiri, Iraj Salehi, Siamak Shahidi, Alireza Komaki, Mehdi Mehdizadeh, Fahimeh Ghasemi Moravej, Sara Soleimani Asl
3,4-methylenedioxymethamphetamine (MDMA) leads to apoptosis in the hippocampus with consequent induction of learning and memory impairment. In this study, we have investigated the effects of treadmill exercise on memory in relation to apoptosis and oxidative stress in the hippocampi of MDMA-treated rats. Male Wistar rats received multiple intraperitoneal (IP) injections of MDMA (10 mg/kg) and exercised for one month on a treadmill (simultaneously or asynchronously with MDMA). We assessed memory function with the Morris water maze (MWM) test...
May 11, 2017: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/28490663/quantitative-estimated-exposure-to-vinyl-chloride-and-risk-of-angiosarcoma-of-the-liver-and-hepatocellular-cancer-in-the-us-industry-wide-vinyl-chloride-cohort-mortality-update-through-2013
#15
Kenneth A Mundt, Linda D Dell, Lori Crawford, Alexa E Gallagher
OBJECTIVE: To evaluate mortality risks of angiosarcoma of the liver (ASL), primary hepatocellular carcinoma (HCC) and other cancers among 9951 men employed between 1942 and 1972 at 35 US vinyl chloride (VC) or polyvinyl chloride plants followed for mortality through 31 December 2013. METHODS: SMR and time-dependent Cox proportional hazards analyses were used to evaluate mortality risks by cumulative VC exposure. RESULTS: Liver cancer mortality was elevated (SMR=2...
May 10, 2017: Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28488274/quantitative-single-breath-hold-renal-arterial-spin-labeling-imaging-at-7t
#16
Xiufeng Li, Edward J Auerbach, Pierre-Francois Van de Moortele, Kamil Ugurbil, Gregory J Metzger
PURPOSE: To evaluate the feasibility of quantitative single breath-hold renal arterial spin labeling (ASL) imaging at 7T. METHODS: A single-shot fast spin echo FAIR (flow-sensitive alternating inversion recovery) method was used to perform two studies. First, a multi-delay perfusion study was performed to estimate the spin labeling temporal bolus width achievable with a local transceiver array coil at 7T. Second, with a conservatively defined bolus width, a quantitative perfusion study was performed using the single subtraction approach...
May 9, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28488024/glioma-grading-and-determination-of-idh-mutation-status-and-atrx-loss-by-dce-and-asl-perfusion
#17
Cornelia Brendle, Johann-Martin Hempel, Jens Schittenhelm, Marco Skardelly, Ghazaleh Tabatabai, Benjamin Bender, Ulrike Ernemann, Uwe Klose
PURPOSE: To evaluate arterial spin labeling (ASL) perfusion and dynamic contrast-enhanced (DCE) perfusion in glioma grading according to the previous WHO classification of 2007, as well as concerning isocitrate dehydrogenase (IDH) mutation status and ATRX expression as required by the new WHO 2016 brain tumor classification. METHODS: The mean values of Ktrans, Kep, Ve, and Vp by DCE perfusion, and cerebral blood flow (CBF) by ASL perfusion were assessed retrospectively in 40 patients with initial glioma diagnosis...
May 9, 2017: Clinical Neuroradiology
https://www.readbyqxmd.com/read/28487462/association-of-endotoxaemia-with-serum-free-fatty-acids-in-metabolically-healthy-and-unhealthy-abdominally-obese-individuals-a-case-control-study-in-northwest-of-iran
#18
Maryam Saghafi-Asl, Parichehr Amiri, Mahsa Naghizadeh, Seyed Mostafa Ghavami, Nahid Karamzad
OBJECTIVES: This study aimed to compare serum free fatty acids (FFAs) and lipopolysaccharide-binding protein (LBP) between metabolically healthy abdominally obese (MHAO) and metabolically unhealthy abdominally obese (MUAO) individuals. We also examined the association between serum FFAs and LBP in the participants. METHODS: In this age-matched and gender-matched case-control study, 164 abdominally obese subjects were recruited from June to November 2015 in the northwest of Iran...
May 9, 2017: BMJ Open
https://www.readbyqxmd.com/read/28485905/-shifting-from-heroin-to-alcohol-addiction-descriptive-survey
#19
Sergio Borsetti, Johnny Acquaro, Emanuele Bignamini
INTRODUCTION: Addiction is a disease which affects the relation between the person and the object of his addiction. One of the major risks for people addicted to heroin treated with Methadone Maintenance Treatment (MMT) is to develop addiction from another substance, particularly alcohol, while treating heroin addiction, "shifting" this way from heroin addic- tion to alcoholism. OBJECTIVE: describing such "shifting" process within the population taken into considera- tion for this study...
January 2017: Professioni Infermieristiche
https://www.readbyqxmd.com/read/28483234/identification-of-a-novel-missence-mutation-in-fgfr3-gene-in-an-iranian-family-with-ladd-syndrome-by-next-generation-sequencing
#20
Farah Talebi, Farideh Ghanbari Mardasi, Javad Mohammadi Asl, Amir Hooshang Bavarsad, Saeed Tizno
Lacrimo-auriculo-dento-digital syndrome (LADD) is a multiple congenital anomaly and a genetically heterogeneous disorder. The aim of this study was to identify the pathogenic gene in an Iranian family with LADD syndrome and review the literature on reported mutations that involved in pathogenesis of LADD syndrome. One novel variant, c.1882 G > A, in fibroblast growth factor receptor 3 (FGFR3) was identified by next generation sequencing and Sanger sequencing. The heterozygous FGFR3 c.1882 G > A variant results in substitution of aspartic acid with asparagine at amino acid 628 (p...
June 2017: International Journal of Pediatric Otorhinolaryngology
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