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https://www.readbyqxmd.com/read/29135072/measuring-human-placental-blood-flow-with-multidelay-3d-grase-pseudocontinuous-arterial-spin-labeling-at-3t
#1
Xingfeng Shao, Dapeng Liu, Thomas Martin, Teresa Chanlaw, Sherin U Devaskar, Carla Janzen, Aisling M Murphy, Daniel Margolis, Kyunghyun Sung, Danny J J Wang
BACKGROUND: Placenta influences the health of both a woman and her fetus during pregnancy. Maternal blood supply to placenta can be measured noninvasively using arterial spin labeling (ASL). PURPOSE: To present a multidelay pseudocontinuous arterial spin labeling (pCASL) combined with a fast 3D inner-volume gradient- and spin-echo (GRASE) imaging technique to simultaneously measure placental blood flow (PBF) and arterial transit time (ATT), and to study PBF and ATT evolution with gestational age during the second trimester...
November 14, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29134725/reproducibility-of-brain-mri-segmentation-algorithms-empirical-comparison-of-local-map-pstaple-freesurfer-and-fsl-first
#2
Clemente Velasco-Annis, Alireza Akhondi-Asl, Aymeric Stamm, Simon K Warfield
BACKGROUND AND PURPOSE: Segmentation of human brain structures is crucial for the volumetric quantification of brain disease. Advances in algorithmic approaches have led to automated techniques that save time compared to interactive methods. Recently, the utility and accuracy of template library fusion algorithms, such as Local MAP PSTAPLE (PSTAPLE), have been demonstrated but there is little guidance regarding its reproducibility compared to single template-based algorithms such as FreeSurfer and FSL-FIRST...
November 14, 2017: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
https://www.readbyqxmd.com/read/29123085/airway-surface-liquid-ph-is-not-acidic-in-children-with-cystic-fibrosis
#3
André Schultz, Ramaa Puvvadi, Sergey M Borisov, Nicole C Shaw, Ingo Klimant, Luke J Berry, Samuel T Montgomery, Thien Nguyen, Silvia M Kreda, Anthony Kicic, Peter B Noble, Brian Button, Stephen M Stick
Modulation of airway surface liquid (ASL) pH has been proposed as a therapy for cystic fibrosis (CF). However, evidence that ASL pH is reduced in CF is limited and conflicting. The technical challenges associated with measuring ASL pH in vivo have precluded accurate measurements in humans. In order to address this deficiency, ASL pH was measured in vivo in children using a novel luminescent technology integrated with fibre-optic probes. Here we show that ASL pH in children with CF is similar to that of children without CF...
November 10, 2017: Nature Communications
https://www.readbyqxmd.com/read/29121489/health-impacts-quantification-of-ambient-air-pollutants-using-airq-model-approach-in-hamadan-iran
#4
Farshad Bahrami Asl, Mostafa Leili, Yaser Vaziri, Soheila Salahshour Arian, Antonio Cristaldi, Gea Oliveri Conti, Margherita Ferrante
Iranian western cities, including Hamadan, have been experiencing Middle East Dust Storms (MEDS) phenomenon problems in recent years, so the air quality is getting worse every year in these cities. The aim of this study was to evaluate the human health impacts of criteria air pollutants including PM10, PM2.5, NO2, SO2, CO and O3 on the citizens of Hamadan using AirQ model software 2.2.3. Considering the determined baseline incidence (BI) and relative risk (RR) rate, the attributable proportion (AP) of deaths due to cardiovascular and respiratory mortality attributed to PM2...
November 6, 2017: Environmental Research
https://www.readbyqxmd.com/read/29114921/association-of-early-left-ventricular-dysfunction-with-advanced-magnetic-resonance-white-matter-and-gray-matter-brain-measures-the-cardia-study
#5
Anderson C Armstrong, Majon Muller, Bharath Ambale-Ventakesh, Michael Halstead, Satoru Kishi, Nick Bryan, Stephen Sidney, Luís C L Correia, Samuel S Gidding, Lenore J Launer, João A C Lima
INTRODUCTION: Relations between heart failure and clinically manifested stroke are well known, but the associations between heart and brain early abnormalities are not totally clear. AIMS: We explore relations of subclinical brain abnormalities with early cardiac dysfunction in a large healthy middle-aged biracial cohort. METHODS: The CARDIA study enrolled 5115 young adults aged 18-30 years at baseline (1985-1986). We assessed 719 Caucasian and African American participants of the CARDIA study, with echocardiograms and brain MRI at follow-up year 25 (2010-2011)...
November 8, 2017: Echocardiography
https://www.readbyqxmd.com/read/29112620/evaluation-of-the-accuracy-of-polymer-gels-for-determining-electron-dose-distributions-in-the-presence-of-small-heterogeneities
#6
R Ghahraman Asl, H A Nedaie, N Banaee
The aim of this study is to evaluate the application and accuracy of polymer gels for determining electron dose distributions in the presence of small heterogeneities made of bone and air. Different cylindrical phantoms containing MAGIC (Methacrylic and Ascorbic acid in Gelatin Initiated by Copper) normoxic polymer gel were used under the slab phantoms during irradiation. MR images of the irradiated gel phantoms were obtained to determine their R2 (spin-spin) relaxation maps for conversion to absorbed dose...
December 2017: Health Physics
https://www.readbyqxmd.com/read/29111560/identification-of-a-novel-mutation-in-arsa-gene-in-three-patients-of-an-iranian-family-with-metachromatic-leukodystrophy-disorder
#7
Neda Golchin, Mohammadreza Hajjari, Reza Azizi Malamiri, Majid Aminzadeh, Javad Mohammadi-Asl
Metachromatic leukodystrophy disorder (MLD) is an autosomal recessive and lysosomal storage disease. The disease is caused by the deficiency of the enzyme arylsulfatase A (ARSA) which is encoded by the ARSA gene. Different mutations have been reported in different populations. The present study was aimed to detect the mutation type of the ARSA gene in three relative Iranian patients. We found a novel homozygous missense mutation c.1070 G > T (p.Gly357Val) in exon 6 of these patients. The mutation was found to be reported for the first time in MLD patients...
November 6, 2017: Genetics and Molecular Biology
https://www.readbyqxmd.com/read/29109328/semi-automated-carotid-lumen-segmentation-in-computed-tomography-angiography-images
#8
Hamid Reza Hemmati, Mahdi Alizadeh, Alireza Kamali-Asl, Shapour Shirani
Carotid artery stenosis causes narrowing of carotid lumens and may lead to brain infarction. The purpose of this study was to develop a semi-automated method of segmenting vessel walls, surrounding tissues, and more importantly, the carotid artery lumen by contrast computed tomography angiography (CTA) images and to define the severity of stenosis and present a three-dimensional model of the carotid for visual inspection. In vivo contrast CTA images of 14 patients (7 normal subjects and 7 patients undergoing endarterectomy) were analyzed using a multi-step segmentation algorithm...
November 5, 2017: Journal of Biomedical Research
https://www.readbyqxmd.com/read/29107006/conformational-preferences-and-structural-analysis-of-hypermodified-nucleoside-peroxywybutosine-o2yw-found-at-37th-position-in-anticodon-loop-of-trna-phe-and-its-role-in-modulating-uuc-codon-anticodon-interactions
#9
Prayagraj M Fandilolu, Asmita S Kamble, Susmit B Sambhare, Kailas D Sonawane
Hypermodified bases present at 3'-adjacent (37th) position in anticodon loop of tRNA(Phe) are well known for their contribution in modulating codon-anticodon interactions. Peroxywybutosine (o2yW), a wyosine family member, is one of such tricyclic modified base observed at the 37th position in tRNA(Phe). Conformational preferences and three-dimensional structural analysis of peroxywybutosine have not been investigated in detail at atomic level. Hence, in the present study quantum chemical semi-empirical RM1 and multiple molecular dynamics (MD) simulations have been used to study structural significance of peroxywybutosine in tRNA(Phe)...
October 26, 2017: Gene
https://www.readbyqxmd.com/read/29106745/demonstration-of-velocity-selective-myocardial-arterial-spin-labeling-perfusion-imaging-in-humans
#10
Terrence R Jao, Krishna S Nayak
PURPOSE: Transit delay is a potential source of error in cardiac arterial spin-labeled (ASL) in heart failure or with collateral circulation. This study demonstrates the feasibility of using transit delay insensitive velocity selective ASL and compares its performance with flow-sensitive alternating inversion recovery (FAIR) ASL. METHODS: Velocity selective labeling was achieved using an adiabatic BIR8 preparation. FAIR and velocity-selective ASL (VSASL) with various velocity cutoffs (VC  = 10-40 cm/s) and labeling directions (anterior-posterior X, lateral-septal Y, and apical-basal Z) were carried out in 10 healthy volunteers (1F/9M age 23-30 y)...
November 6, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29105531/the-relationship-between-children-s-media-habits-and-their-anxiety-and-behaviour-during-dental-treatment
#11
Zahra Jamali, Masoumeh Vatandoost, Leila Erfanparast, Naser Asl Aminabadi, Sajjad Shirazi
OBJECTIVE: The existing evidence suggests that media habits may have moderating role on children's psychological adjustment in the dental setting. The aim of this study was to investigate the relationship between children's media habits and their anxiety and behaviour management problems (BMP) during dental treatment. MATERIALS AND METHODS: A total of 289 children aged 3-6 years old were included. Dental anxiety (DA) and BMP were assessed using Clinical Anxiety Rating Scale and Frankl's Rating Scale during the dental treatment...
November 5, 2017: Acta Odontologica Scandinavica
https://www.readbyqxmd.com/read/29105017/patch-based-local-learning-method-for-cerebral-blood-flow-quantification-with-arterial-spin-labeling-mri
#12
Hancan Zhu, Guanghua He, Ze Wang
Arterial spin-labeling (ASL) perfusion MRI is a non-invasive method for quantifying cerebral blood flow (CBF). Standard ASL CBF calibration mainly relies on pair-wise subtraction of the spin-labeled images and controls images at each voxel separately, ignoring the abundant spatial correlations in ASL data. To address this issue, we previously proposed a multivariate support vector machine (SVM) learning-based algorithm for ASL CBF quantification (SVMASLQ). But the original SVMASLQ was designed to do CBF quantification for all image voxels simultaneously, which is not ideal for considering local signal and noise variations...
November 6, 2017: Medical & Biological Engineering & Computing
https://www.readbyqxmd.com/read/29104070/the-role-of-amniotic-membrane-extract-eye-drop-ameed-in-in-vivo-cultivation-of-limbal-stem-cells
#13
Alireza Baradaran-Rafii, Niloufar Shayan Asl, Marzieh Ebrahimi, Sayena Jabbehdari, Shahram Bamdad, Danial Roshandel, Medi Eslani, Maryam Momeni
BACKGROUND: Limbal stem cell transplantation (LSCT) is the definitive treatment for total limbal stem cell deficiency (LSCD). This study evaluates the anatomical and visual outcomes of a surgical technique supplemented by amniotic membrane extract eye drop (AMEED) for in vivo cultivation of limbal stem cells (LSCs). METHODS: One small limbal block (2 × 1 mm) harvested from the contralateral healthy eye was transferred to the diseased eye, which had been already covered by cryopreserved amniotic membrane (N = 20)...
November 2, 2017: Ocular Surface
https://www.readbyqxmd.com/read/29102059/on-chip-pulsed-electromembrane-extraction-as-a-new-concept-for-analysis-of-biological-fluids-in-a-small-device
#14
Monireh Karami, Yadollah Yamini, Yousef Abdossalami Asl, Maryam Rezazadeh
In the present work, an on-chip pulsed electromembrane extraction technique followed by HPLC-UV was developed for the analysis of codeine, naloxone and naltrexone as model analytes in biological fluids. The chip consisted of two channels for the introduction of the donor and acceptor phases. The channels were carved in two poly (methyl methacrylate) plates and a porous polypropylene membrane, which is impregnated by an organic solvent separating the two channels. Two platinum electrodes were mounted on the bottom of these channels and a pulsed electrical voltage was applied as an electrical driving force for the migration of ionized analytes from the sample solution through the porous sheet membrane into the acceptor phase...
October 23, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29100060/network-analysis-reveals-a-causal-role-of-mitochondrial-gene-activity-in-atherosclerotic-lesion-formation
#15
Baiba Vilne, Josefin Skogsberg, Hassan Foroughi Asl, Husain Ahammad Talukdar, Thorsten Kessler, Johan L M Björkegren, Heribert Schunkert
BACKGROUND AND AIMS: Mitochondrial damage and augmented production of reactive oxygen species (ROS) may represent an intermediate step by which hypercholesterolemia exacerbates atherosclerotic lesion formation. METHODS: To test this hypothesis, in mice with severe but genetically reversible hypercholesterolemia (i.e. the so called Reversa mouse model), we performed time-resolved analyses of mitochondrial transcriptome in the aortic arch employing a systems-level network approach...
October 21, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29095407/serious-adverse-events-significantly-reduce-patient-reported-outcomes-at-2-year-follow-up-nonoperative-multicenter-prospective-nih-study-of-105-patients
#16
Andrew J Pugely, Michael P Kelly, Christine R Baldus, Yubo Gao, Lukas Zebala, Christopher Shaffrey, Steven Glassman, Oheneba Boachie-Adjei, Stefan Parent, Stephen Lewis, Tyler Koski, Charles Edwards, Frank Schwab, Keith H Bridwell
STUDY DESIGN: This is an analysis of a prospective 2-year study on nonoperative patients enrolled in the Adult Symptomatic Lumbar Scoliosis (ASLS) National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) trial. OBJECTIVE: The purpose was to evaluate the impact of serious adverse events (SAEs) on patient-reported outcomes (PROs) in nonoperative management of ASLS as measured by Scoliosis Research Society-22r (SRS-22r), Oswestry Disability Index (ODI) and Short Form-12 (SF-12) at 2-year follow-up...
October 31, 2017: Spine
https://www.readbyqxmd.com/read/29095282/skull-metastases-detecting-on-arterial-spin-labeling-perfusion-three-case-reports-and-review-of-literature
#17
REVIEW
Kyeong H Ryu, Hye J Baek, Soo B Cho, Jin I Moon, Bo H Choi, Sung E Park, Hyo J An
RATIONALE: Detection of skull metastases is as important as detection of brain metastases because early diagnosis of skull metastases is a crucial determinant of treatment. However, the skull can be a blind spot for assessing metastases on routine brain magnetic resonance imaging (MRI). To the best of our knowledge, the finding of skull metastases on arterial spin labeling (ASL) has not been reported. ASL is a specific MRI sequence for evaluating cerebral blood flow using magnetized endogenous inflow blood...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29079438/immobilization-of-lysozyme-on-bacterial-cellulose-nanofibers-characteristics-antimicrobial-activity-and-morphological-properties
#18
Pashew Bayazidi, Hadi Almasi, Asghar Khosrowshahi Asl
The aim of this study was to immobilize of lysozyme onto bacterial cellulose nanofibers (BCNF) using physical absorption method. Antimicrobial activity and other properties of immobilized lysozyme and also morphological characteristics of BCNF were studied. Activity of lysozyme was decreased about 12% after immobilization. The lysozyme concentration of 1mg/ml was chosen for next studies on immobilized enzyme. The optimum pH and temperature were recorded as 7 and 45°C, respectively for immobilized enzyme. Storage stability was increased and immobilized lysozyme exhibited more than 70% of its initial activity after 9 cycles...
October 25, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29067848/distinct-clinical-correlates-of-immune-thrombocytopenic-purpura-at-diagnosis-of-childhood-onset-and-adult-sle
#19
Gladys Cherres Xavier Esteves, Natali Weniger Spelling Gormezano, Oriany L Pereira, David Kern, Clovis Almeida Silva, Rosa Maria Rodrigues Pereira, Katia Tomie Kozu, Eloisa Bonfá, Nadia Emi Aikawa
OBJECTIVES: To compare clinical and laboratorial features between childhood-onset systemic lupus erythematosus (cSLE) and adult SLE (aSLE) at concomitant diagnosis of immune thrombocytopenic purpura (ITP). METHODS: This study evaluated 56 cSLE and 73 aSLE patients regularly followed at Pediatric and Rheumatology Divisions of the same University hospital with ITP (platelets count <100,000/mm(3) in the absence of other causes) at lupus onset. RESULTS: Median current age was 11...
October 25, 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/29066588/effect-of-high-flow-nasal-cannula-on-expiratory-pressure-and-ventilation-in-infant-pediatric-and-adult-models
#20
Katie R Nielsen, Laura E Ellington, Alan J Gray, Larissa I Stanberry, Lincoln S Smith, Robert M DiBlasi
BACKGROUND: Heated and humidified high-flow nasal cannula (HFNC) is a widely used form of respiratory support; however, data regarding optimal flows for a given patient size or disease state are lacking. A comprehensive study of the physiologic effects of HFNC is needed to better understand the mechanisms of action. The objective of the current study was to quantify the effect of HFNC settings in age-specific, anatomically correct nasal airways and spontaneously breathing lung models...
October 24, 2017: Respiratory Care
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