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https://www.readbyqxmd.com/read/27903283/systematic-analysis-of-chromatin-interactions-at-disease-associated-loci-links-novel-candidate-genes-to-inflammatory-bowel-disease
#1
Claartje A Meddens, Magdalena Harakalova, Noortje A M van den Dungen, Hassan Foroughi Asl, Hemme J Hijma, Edwin P J G Cuppen, Johan L M Björkegren, Folkert W Asselbergs, Edward E S Nieuwenhuis, Michal Mokry
BACKGROUND: Genome-wide association studies (GWAS) have revealed many susceptibility loci for complex genetic diseases. For most loci, the causal genes have not been identified. Currently, the identification of candidate genes is predominantly based on genes that localize close to or within identified loci. We have recently shown that 92 of the 163 inflammatory bowel disease (IBD)-loci co-localize with non-coding DNA regulatory elements (DREs). Mutations in DREs can contribute to IBD pathogenesis through dysregulation of gene expression...
November 30, 2016: Genome Biology
https://www.readbyqxmd.com/read/27898185/perfusion-has-no-effect-on-the-in-vivo-cest-effect-from-cr-crcest-in-skeletal-muscle
#2
Feliks Kogan, Randall B Stafford, Erin K Englund, Garry E Gold, Hari Hariharan, John A Detre, Ravinder Reddy
Creatine, a key component of muscle energy metabolism, exhibits a chemical exchange saturation transfer (CEST) effect between its amine group and bulk water, which has been exploited to spatially and temporally map creatine changes in skeletal muscle before and after exercise. In addition, exercise leads to an increase in muscle perfusion. In this work, we determined the effects of perfused blood on the CEST effects from creatine in skeletal muscle. Experiments were performed on healthy human subjects (n = 5) on a whole-body Siemens 7T magnetic resonance imaging (MRI) scanner with a 28-channel radiofrequency (RF) coil...
November 29, 2016: NMR in Biomedicine
https://www.readbyqxmd.com/read/27897253/hyperglycaemia-and-pseudomonas-aeruginosa-acidify-cystic-fibrosis-airway-surface-liquid-by-elevating-epithelial-monocarboxylate-transporter-2-dependent-lactate-h-secretion
#3
James Peter Garnett, Kameljit K Kalsi, Mirko Sobotta, Jade Bearham, Georgina Carr, Jason Powell, Malcolm Brodlie, Christopher Ward, Robert Tarran, Deborah L Baines
The cystic fibrosis (CF) airway surface liquid (ASL) provides a nutrient rich environment for bacterial growth including elevated glucose, which together with defective bacterial killing due to aberrant HCO3(-) transport and acidic ASL, make the CF airways susceptible to colonisation by respiratory pathogens such as Pseudomonas aeruginosa. Approximately half of adults with CF have CF related diabetes (CFRD) and this is associated with increased respiratory decline. CF ASL contains elevated lactate concentrations and hyperglycaemia can also increase ASL lactate...
November 29, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27893467/bullous-pyoderma-gangrenosum-with-subungual-involvement-associated-with-ulcerative-colitis
#4
Ezgi Aktaş Karabay, Asl Aksu Cerman, İlknur Kvanc Altunay, Özben Yalçn
Pyoderma gangrenosum (PG) is a rare inflammatory and ulcerative skin disease of unknown etiology characterized by neutrophilic infiltration of the dermis, mainly affecting the lower extremities. Bullous PG is a rare variant of this disease, usually associated with hematologic disorders. Here, we report a case of pathergy-positive bullous PG with subungual involvement associated with ulcerative colitis.
November 22, 2016: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/27892592/mechanical-properties-and-current-carrying-capacity-of-al-reinforced-with-graphene-bn-nanoribbons-a-computational-study
#5
D G Kvashnin, M Ghorbani-Asl, D V Shtansky, D Golberg, A V Krasheninnikov, P B Sorokin
Record high values of Young's modulus and tensile strength of graphene and BN nanoribbons as well as their chemically active edges make them promising candidates for serving as fillers in metal-based composite materials. Herein, using ab initio and analytical potential calculations we carry out a systematic study of the mechanical properties of nanocomposites constructed by reinforcing an Al matrix with BN and graphene nanoribbons. We consider a simple case of uniform distribution of nanoribbons in an Al matrix under the assumption that such configuration will lead to the maximum enhancement of mechanical characteristics...
November 28, 2016: Nanoscale
https://www.readbyqxmd.com/read/27890078/animal-fascioliasis-perspectives-from-high-altitudinal-regions
#6
Damanbha Lyngdoh, Sunil Sharma, Bishnupada Roy, Veena Tandon
The parasitic flukes of the genus Fasciola (Platyhelminthes: Trematoda: Digenea) cause fascioliasis or liver-rot disease in ruminant livestock in tropical and sub-tropical regions of the world. Classically, two species of Fasciola- F. hepatica and F. gigantica, are universally recognized as taxonomically valid species. Our survey studies on ovid and bovid animals including yak and mithun from high altitudinal mountainous regions in Northeast India revealed the occurrence of Fasciola gigantica and also Fasciola sp...
December 15, 2016: Veterinary Parasitology
https://www.readbyqxmd.com/read/27888603/development-of-a-mechanical-sexing-system-to-improve-the-efficacy-of-a-sterile-insect-area-wide-release-program-to-control-american-serpentine-leafminer-diptera-agromyzidae-in-canadian-ornamental-greenhouses
#7
Maryam Sultan, Rose Buitenhuis, Graeme Murphy, Cynthia D Scott-Dupree
BACKGROUND: American serpentine leafminer (ASL), Liriomyza trifolii (Burgess), are a significant pest of greenhouse ornamental crops and females damage leaf tissue with their ovipositor during feeding and oviposition. The sterile insect technique has been advocated as a non-chemical alternative to currently available control methods. In area-wide sterile insect release programs, males act as true vectors of sterility. Females should be eliminated from a cohort of pupae prior to irradiation to maximize production economics and sterility spread...
November 26, 2016: Pest Management Science
https://www.readbyqxmd.com/read/27886710/automated-diagnosis-of-coronary-artery-disease-cad-patients-using-optimized-svm
#8
Azam Davari Dolatabadi, Siamak Esmael Zadeh Khadem, Babak Mohammadzadeh Asl
BACKGROUND AND OBJECTIVE: Currently Coronary Artery Disease (CAD) is one of the most prevalent diseases, and also can lead to death, disability and economic loss in patients who suffer from cardiovascular disease. Diagnostic procedures of this disease by medical teams are typically invasive, although they do not satisfy the required accuracy. METHODS: In this study, we have proposed a methodology for the automatic diagnosis of normal and Coronary Artery Disease conditions using Heart Rate Variability (HRV) signal extracted from electrocardiogram (ECG)...
January 2017: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/27884866/a-case-of-specific-language-impairment-in-a-deaf-signer-of-american-sign-language
#9
David Quinto-Pozos, Jenny L Singleton, Peter C Hauser
This article describes the case of a deaf native signer of American Sign Language (ASL) with a specific language impairment (SLI). School records documented normal cognitive development but atypical language development. Data include school records; interviews with the child, his mother, and school professionals; ASL and English evaluations; and a comprehensive neuropsychological and psychoeducational evaluation, and they span an approximate period of 7.5 years (11;10-19;6) including scores from school records (11;10-16;5) and a 3...
November 23, 2016: Journal of Deaf Studies and Deaf Education
https://www.readbyqxmd.com/read/27884779/gene-targeted-next-generation-sequencing-identifies-pnpla1-mutations-in-patients-with-a-phenotypic-spectrum-of-autosomal-recessive-congenital-ichthyosis-the-impact-of-consanguinity
#10
Hassan Vahidnezhad, Leila Youssefian, Amir Hossein Saeidian, Sirous Zeinali, Parvin Mansouri, Soheila Sotoudeh, Mohammadreza Barzegar, Javad Mohammadi-Asl, Razieh Karamzadeh, Maryam Abiri, Kevin McCormick, Paolo Fortina, Jouni Uitto
Autosomal recessive congenital ichthyosis (ARCI) is a heterogeneous group of disorders associated with mutations in at least nine distinct genes. To ascertain the molecular basis of ichthyosis patients in Iran, a country of ∼80 million people with high prevalence of customary consanguineous marriages, we have developed a gene targeted next generation sequencing array consisting of 38 genes reported in association with ichthyosis phenotypes. In a subset of nine extended consanguineous families we found homozygous missense mutations in the PNPLA1 gene, six of them being distinct and previously unpublished...
November 21, 2016: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/27879380/performance-of-leak-compensation-in-all-age-icu-ventilators-during-volume-targeted-neonatal-ventilation-a-lung-model-study
#11
Taiga Itagaki, Desmond J Bennett, Christopher T Chenelle, Daniel F Fisher, Robert M Kacmarek
BACKGROUND: Volume-targeted ventilation is increasingly used in low birthweight infants because of the potential for reducing volutrauma and avoiding hypocapnea. However, it is not known what level of air leak is acceptable during neonatal volume-targeted ventilation when leak compensation is activated concurrently. METHODS: Four ICU ventilators (Servo-i, PB980, V500, and Avea) were compared in available invasive volume-targeted ventilation modes (pressure control continuous spontaneous ventilation [PC-CSV] and pressure control continuous mandatory ventilation [PC-CMV])...
November 22, 2016: Respiratory Care
https://www.readbyqxmd.com/read/27878455/structural-insight-into-binding-mode-of-9-hydroxy-aristolochic-acid-diclofenac-and-indomethacin-to-pla2
#12
Mohsen Ebrahimi, Omidreza Firuzi, Ramin Miri, Nima Razzaghi-Asl, Ahmad Ebadi
Phospholipase A2 (PLA2) catalyzes the hydrolysis of phospholipids into arachidonic acid and lysophospholipids. Arachidonic acid is modified by cyclooxygenases into active compounds called eicosanoids that act as signaling molecules in a number of physiological processes. Excessive production of eicosanoids leads to several pathological conditions such as inflammation. In order to block the inflammatory effect of these compounds, upstream enzymes such as PLA2 are valid targets. In the present contribution, molecular dynamic analysis was performed to evaluate the binding of diclofenac, 9-hydroxy aristolochic acid (9-HAA) and indomethacin to PLA2...
November 22, 2016: Interdisciplinary Sciences, Computational Life Sciences
https://www.readbyqxmd.com/read/27876537/artificial-neural-networks-approach-to-pharmacokinetic-model-selection-in-dce-mri-studies
#13
Mohammad-Reza Mohammadian-Behbahani, Ali-Reza Kamali-Asl
PURPOSE: In pharmacokinetic analysis of Dynamic Contrast Enhanced MRI data, a descriptive physiological model should be selected properly out of a set of candidate models. Classical techniques suggested for this purpose suffer from issues like computation time and general fitting problems. This article proposes an approach based on Artificial Neural Networks (ANNs) for solving these problems. METHODS: A set of three physiologically and mathematically nested models generated from the Tofts model were assumed: Model I, II and III...
November 19, 2016: Physica Medica: PM
https://www.readbyqxmd.com/read/27874845/collaboration-and-emotions-to-the-test-the-experience-of-file-volunteers-in-hospices
#14
Giulia Mascagni
BACKGROUND AND AIMS: This study seeks to provide an in-depth analysis of care-based interaction in the experiences of volunteers working in lenitherapy (pain therapy) through the case study of hospices in Florence, Italy. METHOD: A qualitative method of data collection was chosen: the field research made use of open-ended questionnaires distributed to trained but unspecialised volunteers (V = 32) and to volunteers with hospital-based medical expertise (PV = 35) acting for the Italian Lenitherapy Foundation (FILe) and operating in hospices within the ex-ASL (Local Health Unit) of Florence...
November 22, 2016: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/27872690/the-effects-of-kainic-acid-induced-seizure-on-gene-expression-of-brain-neurotransmitter-receptors-in-mice-using-rt-2-pcr-array
#15
Taghi Naserpour Farivar, Marjan Nassiri-Asl, Pouran Johari, Reza Najafipour, Farid Hajiali
INTRODUCTION: Kainic acid (KA) induces neuropathological changes in specific regions of the mouse hippocampus comparable to changes seen in patients with chronic temporal lobe epilepsy (TLE). According to different studies, the expression of a number of genes are altered in the adult rat hippocampus after status epilepticus (SE) induced by KA. This study aimed to quantitatively evaluate changes in the gene expression of brain neurotransmitter receptors one week after administration of kainic acid in the mouse hippocampus...
October 2016: Basic and Clinical Neuroscience
https://www.readbyqxmd.com/read/27869120/the-influence-of-large-cations-on-the-electrochemical-properties-of-tunnel-structured-metal-oxides
#16
Yifei Yuan, Chun Zhan, Kun He, Hungru Chen, Wentao Yao, Soroosh Sharifi-Asl, Boao Song, Zhenzhen Yang, Anmin Nie, Xiangyi Luo, Hao Wang, Stephen M Wood, Khalil Amine, M Saiful Islam, Jun Lu, Reza Shahbazian-Yassar
Metal oxides with a tunnelled structure are attractive as charge storage materials for rechargeable batteries and supercapacitors, since the tunnels enable fast reversible insertion/extraction of charge carriers (for example, lithium ions). Common synthesis methods can introduce large cations such as potassium, barium and ammonium ions into the tunnels, but how these cations affect charge storage performance is not fully understood. Here, we report the role of tunnel cations in governing the electrochemical properties of electrode materials by focusing on potassium ions in α-MnO2...
November 21, 2016: Nature Communications
https://www.readbyqxmd.com/read/27867814/the-assessment-of-myometrium-perfusion-in-patients-with-uterine-fibroid-by-arterial-spin-labeling-mri
#17
Nozomi Takahashi, Osamu Yoshino, Osamu Hiraike, Eriko Maeda, Masanobu Nakamura, Masaaki Hori, Miyuki Harada, Kaori Koga, Shigeru Saito, Tomoyuki Fujii, Yutaka Osuga
BACKGROUND: It has been suggested that an inadequate blood supply caused by uterine fibroids may lead to decreasing fertility. Therefore, a quantitative evaluation of blood flow in the uterus might be a good tool for infertility treatments. For the first step, the ability to perform arterial spin labeling (ASL)-MRI in pelvic organs was examined by measuring blood flow in the uterine muscle layer. RESULTS: Three normal volunteer women, seven patients with one uterine fibroid and four patients treated with GnRH analogue for uterine fibroids, were enrolled in this study...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27867170/evaluation-of-appropriate-readout-sequence-for-renal-mri-perfusion-using-astar-asl-technique
#18
Kyoko Takakura, Aki Kido, Koji Fujimoto, Kayo Kiguchi, Yasutaka Fushimi, Naotaka Sakashita, Tokunori Kimura, Kaori Togashi
The aim of this study was to compare true-steady state free precession (True-SSFP) with fast field echo (FFE) as readout imaging sequences for renal arterial spin labeling (ASL), and to optimize the imaging condition. Renal ASL perfusion images were acquired using signal targeting with alternated radio frequency using asymmetric inversion slab (ASTAR) technique with respiratory triggering at 3T MRI system, using either 3D True-SSFP or FFE as the readout sequence. Inversion time (TI) varied from 800 to 2400 ms...
2016: Nihon Hoshasen Gijutsu Gakkai Zasshi
https://www.readbyqxmd.com/read/27864008/renal-plasma-flow-rpf-measured-with-multiple-inversion-time-arterial-spin-labeling-asl-and-tracer-kinetic-analysis-validation-against-a-dynamic-contrast-enhancement-method
#19
Christopher C Conlin, Niels Oesingmann, Bradley Bolster, Yufeng Huang, Vivian S Lee, Jeff L Zhang
PURPOSE: To propose and validate a method for accurately quantifying renal plasma flow (RPF) with arterial spin labeling (ASL). MATERIALS AND METHODS: The proposed method employs a tracer-kinetic approach and derives perfusion from the slope of the ASL difference signal sampled at multiple inversion-times (TIs). To validate the method's accuracy, we performed a HIPAA-compliant and IRB-approved study with 15 subjects (9 male, 6 female; age range 24-73) to compare RPF estimates obtained from ASL to those from a more established dynamic contrast-enhanced (DCE) MRI method...
November 15, 2016: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/27861605/differentiation-of-glioblastoma-from-brain-metastasis-qualitative-and-quantitative-analysis-using-arterial-spin-labeling-mr-imaging
#20
Leonard Sunwoo, Tae Jin Yun, Sung-Hye You, Roh-Eul Yoo, Koung Mi Kang, Seung Hong Choi, Ji-Hoon Kim, Chul-Ho Sohn, Sun-Won Park, Cheolkyu Jung, Chul-Kee Park
PURPOSE: To evaluate the diagnostic performance of cerebral blood flow (CBF) by using arterial spin labeling (ASL) perfusion magnetic resonance (MR) imaging to differentiate glioblastoma (GBM) from brain metastasis. MATERIALS AND METHODS: The institutional review board of our hospital approved this retrospective study. The study population consisted of 128 consecutive patients who underwent surgical resection and were diagnosed as either GBM (n = 89) or brain metastasis (n = 39)...
2016: PloS One
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