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https://www.readbyqxmd.com/read/30517489/-invasive-fusariosis-report-of-three-cases-in-peru
#1
Julio Maquera-Afaray, Giancarlo Pérez-Lazo, Rómulo Rodriguez, Ricardo Illescas, Lourdes Rodriguez, José Hidalgo, Beatriz Bustamante, Celina Herrera, Alberto Díaz
Fusarium species are a group of fungi that cause superficial infections, locally invasive and disseminated disease, which occur mainly in immunocompromised hosts, and occasionally in immunocompetent individuals. We present three cases that show three different clinical forms of Fusarium spp. disease that affected different types of patients (patients with hematological malignancy, chronic kidney disease in peritoneal dialysis and post-surgical for osteoarticular pathology), each with its own characteristics that merit discussion...
July 2018: Revista Peruana de Medicina Experimental y Salud Pública
https://www.readbyqxmd.com/read/30516070/new-markers-of-cell-migration-and-inflammation-in-children-with-chronic-kidney-disease
#2
Kinga Musiał, Danuta Zwolińska
CONTEXT: Chronic kidney disease (CKD) is characterized by immunocompetent cell migration and inflammation. Monocyte chemoattractant protein (MCP)-1 and macrophage colony-stimulating factor (MCSF) stimulate monocyte migration and transition into macrophages, with subsequent release of neopterin. OBJECTIVE: The aim of the study was to analyze these parameters in children with various stages of CKD. MATERIAL AND METHODS: The study group consisted of 41 CKD children, 19 patients on hemodialysis (HD), 22 children on automated peritoneal dialysis (APD), and 23 controls...
December 5, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/30515731/the-other-side-of-the-coin-in-renal-replacement-therapies-the-burden-on-caregivers
#3
Simge Bardak, Serap Demir, Eda Aslan, Kenan Turgutalp, Havva Didem Celikcan, Murside Esra Dolarslan, Cennet Kılıcarslan, Filiz Karasu, Ayse Jini Gunes, Cemal Kurt, Ahmet Kıykım
PURPOSE: Living with end-stage renal disease may be burdensome, not only for patients, but also for caregivers. In this study, we aim to compare caregiver burden, psychological symptoms in caregivers of peritoneal dialysis (PD), hemodialysis (HD), and transplantation (TX), and find out associated factors. METHODS: A total of 43 PD, 42 HD, 42 TX patients and a total of 127 caregivers that were actively involved with the care of their patients' dialysis were enrolled...
December 4, 2018: International Urology and Nephrology
https://www.readbyqxmd.com/read/30514194/unsolved-issues-in-the-treatment-of-spontaneous-peritonitis-in-patients-with-cirrhosis-nosocomial-versus-community-acquired-infections-and-the-role-of-fungi
#4
Alberto Enrico Maraolo, Antonio Riccardo Buonomo, Emanuela Zappulo, Riccardo Scotto, Biagio Pinchera, Ivan Gentile
INTRODUCTION: Historically, spontaneous bacterial peritonitis (SBP) has represented one of the most frequent and relevant infectious complications of advanced liver disease, and this is still valid today. Nevertheless, in recent years the role of fungi as causative pathogens of primary peritonitis in patients with cirrhosis has become not negligible. Another issue is linked with the traditional distinction, instrumental in therapeutic choice, between community-acquired and nosocomial forms, according to the onset...
December 3, 2018: Reviews on Recent Clinical Trials
https://www.readbyqxmd.com/read/30514193/malignant-pleural-effusion-still-a-long-way-to-go
#5
Fausto Meriggi
BACKGROUND: Malignant pleural effusion, which is a common clinical problem in patients with cancer, may be due to both primary thoracic tumours or to a metastatic spread in the chest and constitutes the first sign of disease in approximately 10% of patients. Almost all cancers can potentially produce a pleural effusion. The presence of malignant tumour cells in the pleural fluid is generally indicative of advanced disease and is associated with high morbidity and mortality with reduced therapeutic options...
December 3, 2018: Reviews on Recent Clinical Trials
https://www.readbyqxmd.com/read/30511549/polyarteritis-nodosa-in-case-of-familial-mediterranean-fever
#6
İbrahim Gökçe, Ülger Altuntaş, Deniz Filinte, Harika Alpay
Gökçe İ, Altuntaş Ü, Filinte D, Alpay H. Polyarteritis nodosa in case of familial Mediterranean fever. Turk J Pediatr 2018; 60: 326-330. Familial Mediterranean fever (FMF) is an autosomal recessive disease characterized by recurrent self-limited attacks of fever accompanied by peritonitis, pleuritis, and arthritis. Protracted febrile myalgia syndrome (PFMS) is a rare form of vasculitic disease which is an uncommon dramatic manifestation of FMF, characterized by severe crippling myalgia and high fever. Polyarteritis nodosa (PAN) is a systemic necrotizing vasculitis affecting medium or small arteries...
2018: Turkish Journal of Pediatrics
https://www.readbyqxmd.com/read/30511047/biological-mesh-is-a-safe-and-effective-method-of-abdominal-wall-reconstruction-in-cytoreductive-surgery-for-peritoneal-malignancy
#7
A Tzivanakis, S P Dayal, S J Arnold, F Mohamed, T D Cecil, A K Venkatasubramaniam, B J Moran
Background: Patients with peritoneal malignancy often have multiple laparotomies before referral for cytoreductive surgery (CRS). Some have substantial abdominal wall herniation and tumour infiltration of abdominal incisions. CRS involves complete macroscopic tumour removal and hyperthermic intraperitoneal chemotherapy (HIPEC). Abdominal wall reconstruction is problematic in these patients. The aim of this study was to establish immediate and long-term outcomes of abdominal wall reconstruction with biological mesh in a single centre...
December 2018: BJS open
https://www.readbyqxmd.com/read/30510943/acquired-hemophilia-a-in-solid-cancer-two-case-reports-and-review-of-the-literature
#8
Makoto Saito, Reiki Ogasawara, Koh Izumiyama, Akio Mori, Takeshi Kondo, Masanori Tanaka, Masanobu Morioka, Masahiro Ieko
Acquired hemophilia A (AHA) is a rare, hemorrhagic autoimmune disease, whose pathogenesis involves reduced coagulation factor VIII (FVIII) activity related to the appearance of inhibitors against FVIII. Common etiological factors include autoimmune diseases, malignancy, and pregnancy. We report two cases of AHA in solid cancer. The first case is a 63-year-old man who developed peritoneal and intestinal bleeding after gastrectomy for gastric cancer. He was diagnosed with AHA, and was treated with prednisone, followed by cyclophosphamide...
November 26, 2018: World Journal of Clinical Cases
https://www.readbyqxmd.com/read/30510834/successful-treatment-of-streptococcal-toxic-shock-syndrome-with-both-diffuse-peritonitis-and-necrotizing-fasciitis
#9
Shuichi Sato, Masahiro Ito, Tsuyoshi Sakai, Anri Kaneta, Fumie Sato
Streptococcal toxic shock syndrome (STSS) is a life-threatening disease caused by infection of beta-hemolytic streptococci . Here, we report an uncommon case of STSS with both diffuse peritonitis and necrotizing fasciitis and summarize previous cases. The patient was diagnosed with STSS due to an infection of the soft tissue of the lower extremity after surgery for diffuse peritonitis. The general condition had rapidly deteriorated with multiple organ dysfunction. Immediate intensive care, including mechanical ventilation, hemodiafiltration, and repeated debridement, is indispensable for a favorable outcome...
2018: Case Reports in Surgery
https://www.readbyqxmd.com/read/30510550/effective-targeting-of-tag72-peritoneal-ovarian-tumors-via-regional-delivery-of-car-engineered-t-cells
#10
John P Murad, Anna K Kozlowska, Hee Jun Lee, Maya Ramamurthy, Wen-Chung Chang, Paul Yazaki, David Colcher, John Shively, Mihaela Cristea, Stephen J Forman, Saul J Priceman
Impressive clinical efficacy of chimeric antigen receptor (CAR)-engineered T cell therapy for hematological malignancies have prompted significant efforts in achieving similar responses in solid tumors. The lack of truly restricted and uniform expression of tumor-associated antigens, as well as limited T cell persistence and/or tumor trafficking pose major challenges for successful translation of CAR T cell therapy in solid tumors. Recent studies have demonstrated that aberrantly glycosylated cell surface proteins on tumor cells are amenable CAR targets...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/30509259/spontaneous-splenic-rupture-in-plasmodium-knowlesi-malaria
#11
Chee Yik Chang, Wei Chieng Pui, Khamisah Abdul Kadir, Balbir Singh
BACKGROUND: Plasmodium knowlesi, a malaria parasite typically found in long-tailed and pig-tailed macaques, is the most common cause of human malaria in Malaysian Borneo. Infections in humans result in a spectrum of disease, including fatal outcomes. Spontaneous splenic rupture is a rare, but severe complication of malaria and has not been reported previously for knowlesi malaria. CASE PRESENTATION: A 46-year-old man presented with fever and acute surgical abdomen with concomitant P...
December 4, 2018: Malaria Journal
https://www.readbyqxmd.com/read/30509057/peritoneal-fluid-stimulates-neoplastic-transformation-of-normal-hek-293-cells-by-high-expression-of-pluripotent-genes
#12
Ilona Szabłowska-Gadomska, Magdalena Ducher, Magdalena Orzechowska, Joanna Bogusławska-Duch, Magdalena Kowalska, Helena Poławska, Maciej Małecki
Gynecological cancers constitute a serious problem in the world. Their advanced stages are often characterized by the accumulation of ascites, which leads to spreading of cancer cells outside their primary focus. Despite progress in the treatment, prognoses are still not satisfactory. The main causes of these failures are chemoresistance, metastases and recurrences of the disease, which is influenced by, among others, the microenvironment of cancer cells. This study investigated the effect of the microenvironment, which create ascites derived from patients with ovarian and endometrial cancer to non-gynecological HEK 293 cells...
2018: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://www.readbyqxmd.com/read/30506528/-role-of-medical-oncologists-in-multidisciplinary-team-treatment-of-malignant-acute-abdomen
#13
Yilin Liu, Xiaotian Zhang
Acute abdomen in patients with malignant tumors is called malignant acute abdomen, often seen in the digestive system tumor or abdominal pelvic metastasis of the other primary tumors. Bleeding, perforation, gastrointestinal obstruction, biliary obstruction with infection, acute peritonitis are acute and severe, however, prevention is more important than treatment. For high-risk patients, even if acute abdomen does not occur when the disease is diagnosed, we should make precautions, including actively local treatment of local lymph nodes or primary lesions and careful choice of drugs...
November 25, 2018: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/30506401/cellularity-in-low-grade-pseudomyxoma-peritonei-impacts-recurrence-free-survival-following-cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy
#14
Philipp Horvath, Can Yurttas, Philipp Birk, Florian Struller, Alfred Königsrainer
PURPOSE: Documentation of cellularity in Pseudomyxoma peritonei (PMP) is not performed on a regular basis in everyday clinical practice, but is recommended by the PSOGI (Peritoneal Surface Oncology Group International). We investigated the impact of cellularity in PMP following cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) on recurrence-free survival. METHODS: Data from 25 patients with low-grade (American Joint Committee on Cancer grade G1) PMP were retrospectively evaluated...
December 1, 2018: Langenbeck's Archives of Surgery
https://www.readbyqxmd.com/read/30503267/the-fallopian-tube-precursor-escape-and-narrowing-the-knowledge-gap-to-the-origins-of-high-grade-serous-carcinoma
#15
REVIEW
Thing Rinda Soong, Brooke E Howitt, Neil Horowitz, Marisa R Nucci, Christopher P Crum
Most ovarian carcinomas are high-grade serous carcinomas (HGSC) that contain TP53 mutations, present at advanced stage, and eventually become resistant to chemotherapy. The rapid evolution of this disease has been attributed to an origin in the distal fallopian tube, in the form of serous tubal intraepithelial carcinomas (STICs). This has led to a disease model where malignancy develops first in the tube and spreads to the peritoneum or regional lymph nodes. However, although most early or incidentally discovered HGSCs manifest in the tube with STICs, many advanced HGSCs are not accompanied by a malignancy in the fimbria...
November 29, 2018: Gynecologic Oncology
https://www.readbyqxmd.com/read/30502661/comparison-of-eq-5d-5l-vas-and-sf-6d-in-thai-patients-on-peritoneal-dialysis
#16
Tanita Thaweethamcharoen, Prapaporn Noparatayaporn, Suchai Sritippayawan, Nipa Aiyasanon
OBJECTIVES: To compare the utility scores derived from the 5-level EuroQol 5-dimensional questionnaire (EQ-5D-5L), the visual analogue scale (VAS), and the 6-dimensional health state short form (SF-6D) in Thai patients on peritoneal dialysis. METHODS: Data were obtained from the 36-Item Kidney Disease Quality of Life questionnaire and the EuroQol questionnaires (EQ-5D-5L and VAS) via face-to-face interview for 64 patients on peritoneal dialysis. We compared the ceiling effect of all the utility tools by calculating the proportion at the highest scores...
November 28, 2018: Value in Health Regional Issues
https://www.readbyqxmd.com/read/30502264/murine-models-of-intraperitoneal-perfusion-for-disseminated-colorectal-cancer
#17
Eleanor McCabe-Lankford, Margarita Peterson, Bryce McCarthy, April J Brown, Brad Terry, Laura Galarza-Paez, Nicole Levi-Polyachenko
BACKGROUND: Reproduction of the perfusion used in therapy (hyperthermic intraperitoneal chemotherapy) procedures preclinically represents a valuable asset for investigating new therapeutic agents that may improve patient outcomes. This article provides technical descriptions of our execution of closed and open "coliseum" abdominal perfusion techniques in a mouse model of peritoneal carcinomatosis of colorectal cancer. MATERIALS AND METHODS: BALB/c mice presenting with disseminated colorectal cancer (CT26-luciferin cells) underwent 30-min perfusions mimicking either the closed perfusion or the coliseum perfusion technique...
January 2019: Journal of Surgical Research
https://www.readbyqxmd.com/read/30500926/mortality-and-morbidity-following-exercise-based-renal-rehabilitation-in-patients-with-chronic-kidney-disease-the-effect-of-programme-completion-and-change-in-exercise-capacity
#18
Sharlene A Greenwood, Ellen Castle, Herolin Lindup, Juliet Mayes, Iain Waite, Denise Grant, Emmanuel Mangahis, Olivia Crabb, Kamer Shevket, Iain C Macdougall, Helen L MacLaughlin
Background: Twelve weeks of renal rehabilitation (RR) have been shown to improve exercise capacity in patients with chronic kidney disease (CKD); however, survival following RR has not been examined. Methods: This study included a retrospective longitudinal analysis of clinical service outcomes. Programme completion and improvement in exercise capacity, characterised as change in incremental shuttle walk test (ISWT), were analysed with Kaplan-Meier survival analyses to predict risk of a combined event including death, cerebrovascular accident, myocardial infarction and hospitalisation for heart failure in a cohort of patients with CKD...
November 30, 2018: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/30498704/surgery-for-gastrointestinal-stromal-tumors-state-of-the-art-of-laparoscopic-resection-and-surgery-for-m1-tumors
#19
REVIEW
Ulrich Ronellenfitsch, Peter Hohenberger
Background: The principles of surgery for primary gastrointestinal stromal tumor (GIST) are resection with clear margins without lymphadenectomy, thus enabling organ-preserving resection in many cases. Tumor rupture needs to be avoided, because it entails peritoneal sarcomatosis. Given these preconditions, there is a rationale for laparoscopic resection of primary GIST. In metastatic GIST, surgery cannot achieve cure, but constitutes an important cornerstone of treatment. Resection can be performed either for residual lesions in responding patients, for focally progressive lesions, or as palliative measure in generalized progression...
October 2018: Visceral Medicine
https://www.readbyqxmd.com/read/30486509/back-to-the-future-the-fallopian-tube-precursor-escape-and-a-dualistic-model-of-high-grade-serous-carcinogenesis
#20
T Rinda Soong, David L Kolin, Nathan J Teschan, Christopher P Crum
Beginning with the discovery of the BRCA -associated ovarian cancer susceptibility genes and subsequent detailed examination of risk-reducing salpingo-oophorectomy (RRSO) specimens, a new paradigm of ovarian carcinogenesis has unfolded with attention to the distal fallopian tube. The primary focus has been an early cancer or neoplasm in the fallopian tube which is seen in virtually all incidentally discovered high-grade serous cancers in asymptomatic women. This high-frequency of tubal involvement in early serous neoplasm (usually in the form of serous tubal intraepithelial carcinoma-STIC) has galvanized attention to this organ as a primary source of this disease...
November 28, 2018: Cancers
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