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Peritoneal disease

Kathryn E Darras, Sheldon J Clark, Heejun Kang, Mohammed F Mohammed, Sarah Barrett, Silvia D Chang, Alison C Harris, Savvas Nicolaou, Patrick D McLaughlin
PURPOSE: To evaluate the role of virtual monoenergetic imaging (VMI) in the detection of peritoneal metastatic disease in contrast-enhanced computed tomography (CT) of the abdomen and pelvis and to compare this technique to the conventional 120 kV mixed dataset. MATERIALS AND METHODS: Institutional review board approval was obtained with no informed consent required for this retrospective analysis. 43 consecutive patients with histopathologically confirmed peritoneal disease were scanned using a standard protocol on a 128-section dual-source, dual-energy CT system (100/140 keV)...
August 17, 2018: Abdominal Radiology
Joel Wen Liang Lau, Heidi Sian Ying Chang, Kai Yin Lee, Yong Xiang Gwee, Wen Qiang Lee, Choon Seng Chong
PURPOSE: Palliative primary tumour resection (PTR) has traditionally been used for preventing and treating tumour related complications. PTR impact on survival remains questioned. We aimed to study if PTR can increase overall survival (OS) in patients with unresectable metastatic colorectal cancer (mCRC). METHODS: A retrospective review of a prospectively collected database in a single centre was performed. Patients diagnosed with mCRC from January 2004 to December 2014 were included...
August 17, 2018: Journal of Digestive Diseases
Ilenia Bartolini, Maria Novella Ringressi, Filippo Melli, Matteo Risaliti, Marco Brugia, Enrico Mini, Giacomo Batignani, Paolo Bechi, Luca Boni, Antonio Taddei
Background: Surgical treatment is the cornerstone in the management of colorectal cancer (CRC) liver metastases. The aim of this study is to identify clinicopathological factors affecting disease-free (DFS) and overall survival (OS) in patients undergoing potentially curative liver resection for CRC metastasis. Methods: All consecutive patients undergoing liver resection for first recurrence of CRC from February 2006 to February 2018 were included. Prognostic impact of factors related to the patient, primary and metastatic tumors, was retrospectively tested through univariate and multivariate analyses...
2018: Gastroenterology Research and Practice
Caren van Roekel, Trudy G N Jonges, Tycho M T W Lock
In patients with prostate cancer, metastases mostly develop in bone, lung, liver, pleura and adrenal glands. Prostate carcinoma metastases to the ureter are very rare, and the peritoneum is an even rarer site of prostate metastases. We present two cases of ureteral metastases of prostate cancer, of which one patient also developed malignant ascites and peritoneal metastases. An overview of the literature on these metastatic sites is also provided. Both patients presented with hydronephrosis and a ureteral mass...
August 16, 2018: BMJ Case Reports
V V Barilyak, N A Mileshina, Yu A Moskalets, G A Generalova, M V Markova, E R Tsygankova
The risk factors that contribute to the development of hearing loss in the children with chronic kidney failure (CRF) are complications and/or manifestations of the disease itself as well as the side effects of its treatment. There are many similarities between the anatomical, physiological, and pharmacological features of the nephron and the striavascularis of the cochlea. The objective of the present study was the evaluation of the status of the auditory function in the children presenting with CRF. MATERIAL AND METHODS: A total of 62 children with CRF were examined...
2018: Vestnik Otorinolaringologii
Rita Martins, Carlos Casimiro, Ana Valverde, Jose Campillo
We herein report a rare case of a 25-year-old immunocompetent male patient with disseminated tuberculosis of central nervous system (CNS), first presenting as multiple cerebral lesions with no meningeal involvement. Subsequent diagnostic workup disclosed extensive peritoneal involvement. A broad differential diagnosis was considered, including neoplastic and infectious diseases. The diagnosis was confirmed with positive PCR result for Mycobacterium tuberculosis in the biopsied mesenteric tissue. The patient was started on tuberculostatic regimen with favorable outcome...
2018: Case Reports in Neurological Medicine
Markus W Löffler, Julia Steinhilber, Franz J Hilke, Sebastian P Haen, Hans Bösmüller, Ivonne-Aidee Montes-Mojarro, Irina Bonzheim, Antje Stäbler, Ulrike Faust, Ute Grasshoff, Ingmar Königsrainer, Hans-Georg Rammensee, Lothar Kanz, Alfred Königsrainer, Stefan Beckert, Olaf Riess, Christopher Schroeder
BACKGROUND: The PTEN-hamartoma-tumor-syndrome (PHTS) is caused by germline mutations in Phosphatase and Tensin homolog (PTEN) and predisposes to the development of several typical malignancies. Whereas PTEN mutations have been implicated in the occurrence of malignant mesotheliomas, the genetic landscape of verrucous carcinomas (VC) is largely uncharted. Both VC and malignant peritoneal mesotheliomas (MPM) are exceedingly rare and a potential link between these malignancies and PHTS has never been reported...
August 15, 2018: BMC Medical Genetics
Thomas R Pisanic, Leslie Cope, Shiou-Fu Lin, Ting-Tai Yen, Pornpat Athamanolap, Ryoichi Asaka, Kentaro Nakayama, Amanda N Fader, Tza-Huei Wang, Ie-Ming Shih, Tian-Li Wang
PURPOSE: High-grade serous ovarian carcinoma (HGSOC) typically remains undiagnosed until advanced stages when peritoneal dissemination has already occurred. Here, we sought to identify HGSOC-specific alterations in DNA methylation and assess their potential to provide sensitive and specific detection HGSOC at its earliest stages. EXPERIMENTAL DESIGN: MethylationEPIC genome-wide methylation analysis was performed on a discovery cohort comprising 23 HGSOC, 37 non-HGSOC malignant and 36 cancer-free gynecologic tissue samples...
August 14, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
Kiyotaka Uchiyama, Naoki Washida, Nobuyuki Yube, Takahiro Kasai, Keisuke Shinozuka, Kohkichi Morimoto, Akihito Hishikawa, Hiroyuki Inoue, Hidenori Urai, Aika Hagiwara, Kentaro Fujii, Shu Wakino, Souzana Deenitchina, Hiroshi Itoh
AIMS: Remote monitoring (RM) can improve management of chronic diseases. We evaluated the impact of RM in automated peritoneal dialysis (APD) in a simulation study. MATERIALS AND METHODS: We simulated 12 patient scenarios with common clinical problems and estimated the likely healthcare resource consumption with and without the availability of RM (RM+ and RM- groups, respectively). Scenarios were evaluated 4 times by randomly allocated nephrologist-nurse teams or nephrologist-alone assessors...
August 14, 2018: Clinical Nephrology
Qun Zhang, Renyong Guo, Yu Chen
OBJECTIVE: This study aimed to investigate the relationship between plasma D-dimer level, preoperative complications, and thrombosis in liver transplant recipients. METHODS: The clinical data of 525 liver transplant recipients with end-stage liver disease (ESLD) in the First Affiliated Hospital of Zhejiang University from October 2012 to December 2015 were retrospectively analyzed. The patients were grouped based on thrombosis before and after surgery to determine the risk factors for postoperative thrombosis recurrence...
August 13, 2018: Journal of Clinical Laboratory Analysis
Ben-Chung Cheng, Po-Cheng Chen, Pei-Chin Chen, Cheng-Hsien Lu, Yu-Chi Huang, Kun-Hsien Chou, Shau-Hsuan Li, An-Ni Lin, Wei-Che Lin
OBJECTIVES: The aim of this study was to evaluate the relationship between cognitive impairment and brain perfusion using arterial spin labelling (ASL) in end-stage renal disease (ESRD) patients undergoing PD. METHODS: ESRD patients undergoing PD were recruited. Laboratory screening, neuropsychological tests and ASL magnetic resonance imaging (MRI) were conducted prior to and after 6 months of PD. Age- and sex-matched normal subjects without ESRD served as the control group...
August 13, 2018: European Radiology
Yi-Heng Lin, Ya-Hsin Chen, Heng-Yu Chang, Heng-Kien Au, Chii-Ruey Tzeng, Yen-Hua Huang
Endometriosis is an estrogen-dependent inflammatory disease that affects up to 10% of women of reproductive age and accounts for up to 50% of female infertility cases. It has been highly associated with poorer outcomes of assisted reproductive technology (ART), including decreased oocyte retrieval, lower implantation, and pregnancy rates. A better understanding of the pathogenesis of endometriosis-associated infertility is crucial for improving infertility treatment outcomes. Current theories regarding how endometriosis reduces fertility include anatomical distortion, ovulatory dysfunction, and niche inflammation-associated peritoneal or implantation defects...
August 13, 2018: International Journal of Molecular Sciences
Anusha Thadi, Marian Khalili, William F Morano, Scott D Richard, Steven C Katz, Wilbur B Bowne
Peritoneal metastasis (PM) is an advanced stage malignancy largely refractory to modern therapy. Intraperitoneal (IP) immunotherapy offers a novel approach for the control of regional disease of the peritoneal cavity by breaking immune tolerance. These strategies include heightening T-cell response and vaccine induction of anti-cancer memory against tumor-associated antigens. Early investigations with chimeric antigen receptor T cells (CAR-T cells), vaccine-based therapies, dendritic cells (DCs) in combination with pro-inflammatory cytokines and natural killer cells (NKs), adoptive cell transfer, and immune checkpoint inhibitors represent significant advances in the treatment of PM...
August 10, 2018: Vaccines
Xin Li, Jianping Zhou, Ming Dong, Lianhe Yang
BACKGROUND: Low-grade appendiceal mucinous neoplasms (LAMN) are poorly understood lesions characterized by their potential to spread to the peritoneal cavity as pseudomyxoma peritonei (PMP). The purpose of this study was to investigate the clinical and pathologic features and management of these tumors. METHODS: This was a retrospective study of consecutive patients with LAMN who underwent surgery by a surgical team at the First Affiliated Hospital of China Medical University between 2005 and 2016...
July 30, 2018: European Journal of Surgical Oncology
Yue Shang, Xi-Feng Li, Ming-Ji Jin, Ying Li, Yan-Ling Wu, Quan Jin, Yu Zhang, Xia Li, Min Jiang, Ben-Wen Cui, Li-Hua Lian, Ji-Xing Nan
The current study was aimed to reveal that leucodin, a sesquiterpene lactone from Artemisia capillaris could inhibit the inflammatory response in macrophages and the lipid accumulation in hepatocytes via P2x7R-NLRP3 inflammasome activation. Several types of macrophages including mouse peritoneal macrophages, mouse bone marrow-derived macrophages and human macrophages THP-1 cells were pretreated with different concentrations of leucodin for 1 h and then stimulated with LPS and ATP. LPS plus ATP initiated IL-1β cleavage and release in mouse peritoneal macrophages and peaked at 4 h...
August 9, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Mohammad Esmaeili, Forough Rakhshanizadeh
OBJECTIVES: Trace elements, which have a crucial role in metabolism and enzymatic pathways, are not routinely monitored in the blood of pediatric patients with chronic kidney disease. The present study was carried out to determine the serum levels of copper (Cu), zinc (Zn), selenium (Se), and lead (Pb) in children with ESRD who were currently receiving conservative management or were on long-term hemodialysis or continuous ambulatory peritoneal dialysis. METHODS: This study involved 200 children who met the inclusion criteria...
August 7, 2018: Journal of Renal Nutrition
Bruna Taciane da Silva Bortoleti, Manoela Daiele Gonçalves, Fernanda Tomiotto-Pellissier, Milena Menegazzo Miranda-Sapla, João Paulo Assolini, Amanda Cristina Machado Carloto, Priscila Goes Camargo de Carvalho, Ian Lucas Alves Cardoso, Andréa Name Colado Simão, Nilton Syogo Arakawa, Idessania Nazareth Costa, Ivete Conchon-Costa, Wander Rogério Pavanelli
BACKGROUND: American tegumentary leishmaniasis (ATL) is a zoonotic disease caused by protozoa of the genus Leishmania. The high toxicity, high costs and resistance of some strains to current drugs has prompted the search for therapeutic alternatives for the management of this disease. Sphagneticola trilobata is a plant that has diterpenes as main constituents, including grandiflorenic acid (GFA) that has antiinflammatory, antiprotozoal, antibacterial and antinociceptive activity. PURPOSE: The aim of our study was to determine the effect of GFA on both the promastigotes and the amastigotes of Leishmania amazonensis...
July 15, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
Karen M Watters, Preety Bajwa, Hilary A Kenny
Ovarian cancer progression involves multifaceted and variable tumor microenvironments (TMEs), from the in situ carcinoma in the fallopian tube or ovary to dissemination into the peritoneal cavity as single cells or spheroids and attachment to the mesothelial-lined surfaces of the omentum, bowel, and abdominal wall. The TME comprises the tumor vasculature and lymphatics (including endothelial cells and pericytes), in addition to mesothelial cells, fibroblasts, immune cells, adipocytes and extracellular matrix (ECM) proteins...
August 9, 2018: Cancers
Haruko Iwase, Seigi Furukawa, Takeshi Hirasawa, Satoshi Asai, Tatsuru Ohara, Shinji Hosonuma, Shinichi Endo, Yuki Tazo, Hidetaka Sato, Toshio Takada, Masahide Arai, Masae Ikeda, Masako Shida, Norihito Yoshioka, Akiko Tozawa-Ono, Nao Suzuki, Mikio Mikami, Takashi Onda
OBJECTIVE: Chemotherapy is a standard adjuvant treatment after primary surgery for endometrial cancer in Japan. We aimed to characterize the clinical features of recurrent endometrial cancer (REC) patients in Japan. MATERIALS AND METHODS: We retrospectively reviewed the medical records of 112 REC patients who were primarily treated at 1 of 3 university hospitals in Japan from 2005 to 2012. We analyzed overall survival since the first recurrence (R-OS) in accordance with several factors...
August 7, 2018: International Journal of Gynecological Cancer
Jessica A Vanderlinden, Amanda Ross-White, Rachel Holden, M Khaled Shamseddin, Andrew Day, J Gordon Boyd
IMPORTANCE: Cognitive dysfunction is reportedly highly prevalent among chronic kidney disease (CKD) patients. A variety of screening tools and neuropsychiatric batteries are utilized to quantify the magnitude and nature of this dysfunction in CKD patients. OBJECTIVE: To summarize the neurocognitive testing used and determine what degree cognitive dysfunction is reported in CKD patients. METHODS: Articles published in English containing consenting age of majority participants who were either: pre-dialysis patients, hemodialysis (HD) or peritoneal dialysis (PD) patients, or renal transplant recipients were considered...
August 10, 2018: Nephrology
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