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Arterial spin labelling

Mengqi Liu, Zhiye Chen, Lin Ma
Objective This study was performed to evaluate the test-retest reliability of perfusion of the cortex and subcortical white matter on three-dimensional spiral fast spin echo pseudo-continuous arterial spin labeling (3D-ASL). Methods Eight healthy subjects underwent 3D-ASL and structural imaging at the same time each day for 1 week. ASL data acquisition was performed in the resting state and right finger-tapping state. Cerebral blood flow (CBF) images were calculated, and the CBF values of the precentral cortex (PCC) and precentral subcortical white matter (PCSWM) were automatically extracted based on the structural images and CBF images...
January 1, 2018: Journal of International Medical Research
Xiaodi Li, Yuzhou Wang, Zhanhang Wang, Jianjun Lu, Yan Xu, Jinlong Ye, Zuying Kuang, Bo Li, Mengqiu Pan, Wenming Chen, Shuisheng Lu, Ziyang Zhou, Lina Cheng, Honghao Wang
To compare the utility and limitation of magnetic resonance spectroscopy (MRS) and arterial spin labeling (ASL) in the differentiation between mitochondrial encephalomyopathy, lactic acidosis, plus stroke-like episodes (MELAS) and acute ischemic stroke (AIS), a retrospective review of 17 MELAS and 26 AIS patients were performed. In all patients both MRS and ASL scans were performed within 1 week after admission. Demographic, clinical, laboratory and MR imaging data were reviewed and compared between the two groups...
June 16, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
Jan Petr, Henri J M M Mutsaerts, Enrico De Vita, Rebecca M E Steketee, Marion Smits, Aart J Nederveen, Frank Hofheinz, Jörg van den Hoff, Iris Asllani
OBJECTIVE: Partial volume (PV) correction is an important step in arterial spin labeling (ASL) MRI that is used to separate perfusion from structural effects when computing the mean gray matter (GM) perfusion. There are three main methods for performing this correction: (1) GM-threshold, which includes only voxels with GM volume above a preset threshold; (2) GM-weighted, which uses voxel-wise GM contribution combined with thresholding; and (3) PVC, which applies a spatial linear regression algorithm to estimate the flow contribution of each tissue at a given voxel...
June 18, 2018: Magma
Yiran Li, Sudipto Dolui, Dan-Feng Xie, Ze Wang
BACKGROUND: Due to the low signal-to-noise-ratio (SNR) and unavoidable head motions, the pairwise subtraction perfusion signal extraction process in arterial spin labeling (ASL) perfusion MRI can produce extreme outliers. COMPARISON WITH EXISTING METHODS: We previously proposed an adaptive outlier cleaning (AOC) algorithm for ASL MRI. While it performed well even for clinical ASL data, two issues still exist. One is that if the reference is already dominated by noise, outlier cleaning using low correlation with the mean as a rejection criterion will actually reject the less noisy samples but keep the more noisy ones...
June 14, 2018: Journal of Neuroscience Methods
K M Cobb-Pitstick, N Munjal, R Safier, D D Cummings, G Zuccoli
Hemiplegic migraine is a common cause of acute brain attack in pediatrics. MR imaging sequences useful in differentiating hemiplegic migraine from other entities include arterial spin-labeling, SWI, MRA, and DWI. There has been limited exploration on the simultaneous use of these sequences in pediatrics. We present 12 pediatric patients with acute hemiplegic migraine or migraine with aura who underwent MR imaging within 12 hours of symptom onset. Quantitative and qualitative analyses were performed on arterial spin-labeling; and qualitative analysis, on SWI and MRA sequences...
June 14, 2018: AJNR. American Journal of Neuroradiology
Qiong Ding, Kitora Tanigawa, Jun Kaneko, Mamoru Totsuka, Yoshinori Katakura, Etsuko Imabayashi, Hiroshi Matsuda, Tatsuhiro Hisatsune
In a previously reported double-blind, randomized controlled trial (RCT), we demonstrated that daily supplementation with anserine (750 mg) and carnosine (250 mg) improves brain blood flow and memory function in elderly people. Here, we conducted a sub-analysis of MRI data and test scores from the same RCT to determine whether anserine/carnosine supplementation specifically benefits elderly people carrying the APOE e4 allele, which is a risk gene for accelerated brain aging and for the onset of Alzheimer's Disease...
June 2018: Aging and Disease
Hua-Shan Liu, Erum A Hartung, Abbas F Jawad, Jeffrey B Ware, Nina Laney, Allison M Port, Ruben C Gur, Stephen R Hooper, Jerilynn Radcliffe, Susan L Furth, John A Detre
Purpose To investigate the pathophysiologic effects of chronic kidney disease (CKD) on brain function in children with CKD by correlating cerebral blood flow (CBF) with clinical and behavioral indexes. Materials and Methods In this prospective study, 73 pediatric patients with CKD (mean age, 15.80 years ± 3.63; range, 9-25 years) and 57 control subjects (mean age, 15.65 years ± 3.76; range, 9-25 years) were recruited. CBF measurements were acquired with an MRI arterial spin labeling scheme. Neurocognitive measurements were performed with traditional and computerized neurocognitive batteries...
June 12, 2018: Radiology
Yuqun Zhang, Yuan Yang, Ze Wang, Rongrong Bian, Wenhao Jiang, Yingying Yin, Yingying Yue, Zhenghua Hou, Yonggui Yuan
Background: Asthma is a chronic disease appeared to be associated with depression. But the underpinnings of depression in asthma remain unknown. In order to understand the neural mechanisms of depression in asthma, we used cerebral blood flow (CBF) to probe the difference between depressed asthmatic (DA) and non-depressed asthmatic (NDA) patients. Methods: Eighteen DA patients, 24 NDA patients and 57 healthy controls (HC) received pulsed arterial spin labeling (pASL) scan for measuring CBF, resting-state functional magnetic resonance imaging (rs-fMRI) scan, severity of depression and asthma control assessment, respectively...
2018: Frontiers in Psychiatry
Neetu Soni, Karthika Srindharan, Sunil Kumar, Prabhakar Mishra, Girish Bathla, Jyantee Kalita, Sanjay Behari
Purpose The purpose of this article is to assess the diagnostic performance of arterial spin-labeling (ASL) magnetic resonance perfusion imaging to differentiate neoplastic from non-neoplastic brain lesions. Material and methods This prospective study included 60 consecutive, newly diagnosed, untreated patients with intra-axial lesions with perilesional edema (PE) who underwent clinical magnetic resonance imaging including ASL sequences at 3T. Region of interest analysis was performed to obtain mean cerebral blood flow (CBF) values from lesion (L), PE and normal contralateral white matter (CWM)...
January 1, 2018: Neuroradiology Journal
Lin Ma, Xue-Zhi Li, Ni-Ni Fu, Xiao-Guang Yang, Xiao-Fang Xi, Fei Liu, Yi Ren
OBJECTIVE: To examine the effects of different sensitivities on the effectiveness of acupuncture analgesia by observing activation change characteristics of cerebral areas resulting from the influences of constitutions on analgesia effects and to discuss the response mechanism of central nervous system (CNS) to determine the factor of constitutions on acupuncture efficacy using cerebral functional magnetic resonance imaging arterial spin labeling (fMRI-ASL). METHODS: Participants with different sensitivities were assessed according to standard screening and grouped into two groups: insensitivity group ( n =24) and sensitivity group ( n =22)...
May 25, 2018: Zhen Ci Yan Jiu, Acupuncture Research
Joseph O'Neill
No abstract text is available yet for this article.
July 2018: European Journal of Paediatric Neurology: EJPN
Christopher R Bradley, Eleanor F Cox, Robert A Scott, Martin W James, Phillip Kaye, Guruprasad P Aithal, Susan T Francis, Indra Neil Guha
BACKGROUND AND AIMS: Advancing liver disease results in deleterious changes in a number of critical organs. The ability to measure structure, blood flow and tissue perfusion within multiple organs in a single scan has implications for determining the balance of benefit versus harm for therapies. Our aim was to establish the feasibility of Magnetic Resonance Imaging to assess changes in compensated cirrhosis (CC), and relate this to disease severity and future liver related outcomes (LROs)...
June 7, 2018: Journal of Hepatology
Gemma Modinos, Alice Egerton, Katrina McMullen, Anna McLaughlin, Veena Kumari, Gareth J Barker, Steve C R Williams, Fernando Zelaya
Arterial spin labeling (ASL) provides absolute quantification of resting tissue cerebral blood flow (CBF) as an entirely noninvasive approach with good reproducibility. As a result of neurovascular coupling, ASL provides a useful marker of resting neuronal activity. Recent ASL studies in individuals at clinical high risk of psychosis (CHR) have reported increased resting hippocampal perfusion compared with healthy controls. Schizotypy refers to the presence of subclinical psychotic-like experiences in healthy individuals and represents a robust framework to study neurobiological mechanisms involved in the extended psychosis phenotype while avoiding potentially confounding effects of antipsychotic medications or disease comorbidity...
June 8, 2018: Human Brain Mapping
Dongchao Shen, Bo Hou, Yinyan Xu, Bo Cui, Pan Peng, Xiaolu Li, Hongfei Tai, Kang Zhang, Shuangwu Liu, Hanhui Fu, Jing Gao, Mingsheng Liu, Feng Feng, Liying Cui
Objective: To characterize the patterns of brain atrophy and perfusion as measured by arterial spin labeling (ASL)-MRI, in amyotrophic lateral sclerosis (ALS) patients with varying levels of cognitive deficit, including ALS with frontotemporal dementia (FTD). Methods: A total of 55 ALS patients and 20 healthy controls (HCs) were included, and all participants underwent neuropsychological assessments and MRI scans. According to their cognitive performance, ALS patients were further subclassified into ALS with normal cognition (ALS-Cn, n  = 27), ALS with cognitive impairment (ALS-Ci, n  = 17), and ALS-FTD ( n  = 11)...
2018: Frontiers in Neurology
V A Parfenov, T M Ostroumova, E M Pеrepelova, V A Perepelov, A I Kochetkov, O D Ostroumova
OBJECTIVE: This study aimed to assess the cognitive functions and cerebral blood flow measured with arterial spin labeling (ASL) and their possible correlations with vascular age in untreated middle-aged patients with grade 1-2 essential arterial hypertension (EAH). METHODS: We examined 73 subjects aged 40-59 years (33 with EAH and 40 healthy volunteers [controls]). Neuropsychological assessment included Montreal Cognitive Assessment (MoCA), Trail Making test (part A and part B), Stroop Color and Word Test, verbal fluency test (phonemic verbal fluency and semantic verbal fluency), 10‑item word list learning task...
May 2018: Kardiologiia
Masanobu Ibaraki, Kazuhiro Nakamura, Hideto Toyoshima, Kazuhiro Takahashi, Keisuke Matsubara, Atsushi Umetsu, Josef Pfeuffer, Hideto Kuribayashi, Toshibumi Kinoshita
Pseudo-continuous arterial spin labeling (pCASL) is a completely non-invasive method of cerebral perfusion measurement. However, cerebral blood flow (CBF) quantification is hampered by arterial transit artifacts characterized by bright vascular signals surrounded by decreased signals in tissue regions, which commonly appear in patients with reduced cerebral perfusion pressure. The spatial coefficient of variation (CoV) of pCASL CBF images has been proposed as an alternative region-of-interest (ROI)-based hemodynamic measure to predict prolonged arterial transit time (ATT)...
January 1, 2018: Journal of Cerebral Blood Flow and Metabolism
Alberto Falk Delgado, Francesca De Luca, Danielle van Westen, Anna Falk Delgado
Background: Arterial spin labeling is an MR imaging technique that measures cerebral blood flow (CBF) non-invasively. The aim of the study is to assess the diagnostic performance of Arterial spin labeling (ASL) MR imaging for differentiation between high-grade glioma and low-grade glioma. Methods: Cochrane Library, Embase, Medline and Web of Science Core Collection were searched. Study selection until November 2017. This study was prospectively registered in Prospero (CRD42017080885)...
June 2, 2018: Neuro-oncology
Linda Knutsson, Jiadi Xu, André Ahlgren, Peter C M van Zijl
Chemical exchange saturation transfer (CEST), arterial spin labeling (ASL), and magnetization transfer contrast (MTC) methods generate different contrasts for MRI. However, they share many similarities in terms of pulse sequences and mechanistic principles. They all use RF pulse preparation schemes to label the longitudinal magnetization of certain proton pools and follow the delivery and transfer of this magnetic label to a water proton pool in a tissue region of interest, where it accumulates and can be detected using any imaging sequence...
May 30, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
Danielle N Lyons, Hemendra Vekaria, Teresa Macheda, Vikas Bakshi, David K Powell, Brian T Gold, Ai-Ling Lin, Pat Sulllivan, Adam D Bachstetter
Metabolic uncoupling has been well-characterized during the first minutes-to-days after a traumatic brain injury (TBI), yet mitochondrial bioenergetics during the weeks-to-months after a brain injury is poorly defined, particularly after a mild TBI. We hypothesized that a closed head injury (CHI) would be associated with deficits in mitochondrial bioenergetics at one month after the injury. A significant decrease in state-III (ATP production) and state-V (complex-I) driven mitochondrial respiration was found at 1-month post-injury in adult C57Bl/6J mice...
May 29, 2018: Journal of Neurotrauma
Lingbin Xu, Leiming Xu, Haidong Zhu
The present study aimed to assess the clinical utility of three-dimensional arterial spin labeling (3D-ASL) perfusion imaging in discriminating between benign, intermediate and malignant musculoskeletal tumors, as well as to analyze the correlation between tumor blood flow (TBF) and microvessel density (MVD). 3D-ASL was performed on 44 patients with musculoskeletal tumor using a 3.0-T magnetic resonance system to obtain TBF values prior to surgery. TBF was independently measured by two radiologists. The TBF values of different groups were compared by one-way analysis of variance...
June 2018: Experimental and Therapeutic Medicine
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