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Arterial spin labelling

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https://www.readbyqxmd.com/read/29034514/measurement-of-murine-single-kidney-glomerular-filtration-rate-using-dynamic-contrast-enhanced-mri
#1
Kai Jiang, Hui Tang, Prasanna K Mishra, Slobodan I Macura, Lilach O Lerman
PURPOSE: To develop and validate a method for measuring murine single-kidney glomerular filtration rate (GFR) using dynamic contrast-enhanced MRI (DCE-MRI). METHODS: This prospective study was approved by the Institutional Animal Care and Use Committee. A fast longitudinal relaxation time (T1 ) measurement method was implemented to capture gadolinium dynamics (1 s/scan), and a modified two-compartment model was developed to quantify GFR as well as renal perfusion using 16...
October 16, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29033829/exercise-training-increases-parietal-lobe-cerebral-blood-flow-in-chronic-stroke-an-observational-study
#2
Andrew D Robertson, Susan Marzolini, Laura E Middleton, Vincenzo S Basile, Paul I Oh, Bradley J MacIntosh
Exercise is increasingly recommended as an essential component of stroke rehabilitation, yet uncertainty remains with respect to its direct effect on the cerebral vasculature. The current study first demonstrated the repeatability of pseudo-continuous arterial spin labeling (ASL) magnetic resonance imaging (MRI) in older adults with stroke, and then investigated the change in cerebrovascular function following a 6-month cardiovascular rehabilitation program. In the repeatability study, 12 participants at least 3 months post-stroke underwent two ASL imaging scans 1 month apart...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/29031810/the-role-of-three-dimensional-pseudo-continuous-arterial-spin-labelling-in-grading-and-differentiating-histological-subgroups-of-meningiomas
#3
Y Lu, J Xiong, B Yin, J Wen, L Liu, D Geng
AIM: To evaluate the usefulness of pseudo-continuous arterial spin labelling (pCASL) imaging in grading and differentiating histological subtypes of meningiomas. MATERIALS AND METHODS: In this prospective study, conventional magnetic resonance imaging (MRI) with contrast-enhanced T1-weighted images and pCASL were acquired with a 3 T MRI system before surgery in 125 consecutive patients with suspected meningiomas. Finally, the perfusion parameters were collected from 84 grade I and 23 grade II meningiomas...
October 11, 2017: Clinical Radiology
https://www.readbyqxmd.com/read/29019892/bright-sinus-appearance-on-arterial-spin-labeling-mr-imaging-aids-to-identify-cerebral-venous-thrombosis
#4
Ji Hee Kang, Tae Jin Yun, Roh-Eul Yoo, Byung-Woo Yoon, A Leum Lee, Koung Mi Kang, Seung Hong Choi, Ji-Hoon Kim, Chul-Ho Sohn, Moon Hee Han
Cerebral venous thrombosis is a potentially lethal disease. Early diagnosis is essential to improve its prognosis. However, its early diagnosis based on conventional imaging modalities remains a challenge in clinical settings. The purpose of this study was to evaluate whether bright sinus appearance on arterial spin-labeling perfusion-weighted image (ASL-PWI) could help identify cerebral venous thrombosis.ASL-PWI of 13 patients who were confirmed as cerebral venous thrombosis based on neurologic symptoms and computed tomography (CT) or magnetic resonance (MR) venography (with/without cerebral angiography) were retrospectively analyzed for the presence or absence of the following: bright signal in dural sinus termed "bright sinus appearance"; and hypoperfusion in brain parenchyma drained by thrombosed sinus...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28992987/the-resting-perfusion-pattern-associates-with-functional-decline-in-type-2-diabetes
#5
Weiying Dai, Wenna Duan, Freddy J Alfaro, Anna Gavrieli, Fotini Kourtelidis, Vera Novak
We investigated the relationships between cerebral blood flow (CBF), cognitive, and mobility decline in type 2 diabetes mellitus (T2DM) over a 2-year period. Seventy-three participants (41 T2DM and 32 controls) were evaluated using volumetric CBF with arterial spin labeling perfusion magnetic resonance imaging at baseline and at the 2-year follow-up. Regions with significant CBF differences between T2DM participants and controls at baseline were detected using voxel-wise analysis. Correlation analysis was performed to investigate the association between regional CBF and cognitive or mobility performance over the 2-year span...
September 14, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/28992587/aberrant-resting-state-cerebellar-blood-flow-in-major-depression
#6
Malte S Depping, Nadine D Wolf, Nenad Vasic, Zrinka Sosic-Vasic, Mike M Schmitgen, Fabio Sambataro, Robert C Wolf
BACKGROUND: Abnormal cortical cerebral blood flow and gray matter volume have been frequently reported in patients with major depressive disorder (MDD). In contrast, although the role of the cerebellum in MDD pathophysiology has attracted considerable interest more recently, studies investigating both functional and structural aspects of cerebellar integrity are scarce. METHODS: In this study, we used structural and functional magnetic resonance imaging (MRI) to investigate cerebellar volume and regional cerebellar blood flow (rCBF) at rest in clinically acute MDD patients (n = 22) and healthy controls (n = 18)...
September 28, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28991731/automatic-temporal-segmentation-of-vessels-of-the-brain-using-4d-asl-mra-images
#7
Renzo Phellan, Thomas Lindner, Michael Helle, Alexandre Falcao, Nils Daniel Forkert
OBJECTIVE: Automatic vessel segmentation can be used to process the considerable amount of data generated by four dimensional arterial spin labeling magnetic resonance angiography (4D ASL MRA) images. Previous segmentation approaches for dynamic series of images propose either reducing the series to a temporal average (tAIP) or maximum intensity projection (tMIP) prior to vessel segmentation, or a separate segmentation of each image. The present paper introduces a method that combines both approaches to overcome the specific drawbacks of each technique...
October 5, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28991728/screening-for-cognitive-impairment-by-model-assisted-cerebral-blood-flow-estimation
#8
Toni Lassila, Luigi Yuri Di Marco, Micaela Mitolo, Vincenzo Iaia, Giorgio Levedianos, Annalena Venneri, Alejandro F Frangi
OBJECTIVE: Alzheimer's disease (AD) is a progressive and debilitating neurodegenerative disease; a major health concern in the ageing population with an estimated prevalence of 46 million dementia cases worldwide. Early diagnosis is therefore crucial so mitigating treatments can be initiated at an early stage. Cerebral hypoperfusion has been linked with blood-brain barrier dysfunction in the early stages of AD, and screening for chronic cerebral hypoperfusion in individuals has been proposed for improving the early diagnosis of AD...
October 5, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28983280/fatigue-and-cognitive-fatigability-in-mild-traumatic-brain-injury-are-correlated-with-altered-neural-activity-during-vigilance-test-performance
#9
Marika C Möller, Love Engström Nordin, Aniko Bartfai, Per Julin, Tie-Qiang Li
INTRODUCTION: Fatigue is the most frequently reported persistent symptom following a mild traumatic brain injury (mTBI), but the explanations for the persisting fatigue symptoms in mTBI remain controversial. In this study, we investigated the change of cerebral blood flow during the performance of a psychomotor vigilance task (PVT) by using pseudo-continuous arterial spin labeling (PCASL) MRI technique to better understand the relationship between fatigability and brain activity in mTBI...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28978533/non-invasive-measurement-of-renal-blood-flow-by-magnetic-resonance-imaging-mri-in-rats
#10
Cesar A Romero, Glauber Cabral, Robert A Knight, Guangliang Ding, Edward L Peterson, Oscar A Carretero
Renal blood flow (RBF) provides important information regarding renal physiology and nephropathies. Arterial spin labeling-magnetic resonance imaging (ASL-MRI) is a non-invasive method of measuring blood flow without exogenous contrast media. However, low signal/noise ratio and respiratory motion artifacts are challenges for RBF measurements in small animals. Our objective was to evaluate the feasibility and reproducibility of RBF measures by ASL-MRI using respiratory-gating and navigator correction methods to reduce motion artifacts...
October 4, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28974724/decreased-triple-network-connectivity-in-patients-with-recent-onset-post-traumatic-stress-disorder-after-a-single-prolonged-trauma-exposure
#11
Yang Liu, Liang Li, Baojuan Li, Na Feng, Lihong Li, Xi Zhang, Hongbing Lu, Hong Yin
The triple network model provides a common framework for understanding affective and neurocognitive dysfunctions across multiple disorders, including central executive network (CEN), default mode network (DMN), and salience network (SN). Considering the effect of traumatic experience on post-traumatic stress disorder (PTSD), this study aims to explore the alteration of triple network connectivity in a specific PTSD induced by a single prolonged trauma exposure. With an arterial spin labeling sequence, three networks were first identified using independent component analysis among 10 PTSD patients and 10 healthy survivors, who experienced the same coal mining flood disaster...
October 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28974274/subjective-cognitive-decline-modifies-the-relationship-between-cerebral-blood-flow-and-memory-function-in-cognitively-normal-older-adults
#12
Chelsea C Hays, Zvinka Z Zlatar, Laura Campbell, M J Meloy, Christina E Wierenga
OBJECTIVES: Subjective cognitive decline (SCD), or self-reported cognitive decline despite normal neuropsychological test performance, is a risk factor for objective cognitive decline and Alzheimer's disease (AD). While brain mechanisms contributing to SCD are not well defined, studies show associations with vascular risk factors and altered cerebral blood flow (CBF), raising the hypothesis that those with SCD might be experiencing vascular dysregulation, or a disruption in the normal relationship between CBF and cognition...
October 4, 2017: Journal of the International Neuropsychological Society: JINS
https://www.readbyqxmd.com/read/28971235/self-controlled-super-selective-arterial-spin-labelling
#13
Thomas Lindner, Friederike Austein, Olav Jansen, Michael Helle
OBJECTIVES: Arterial spin labelling (ASL) is a method of non-contrast-enhanced perfusion imaging that is generally based on the acquisition of two images which must be subtracted in order to obtain perfusion-weighted images. This is also the case for some flow territory mapping approaches that require the acquisition of two images for each artery of interest, thereby prolonging scan time and yielding largely redundant information. The aim of this study is to accelerate flow territory mapping using ASL by eliminating the acquisition of a control condition...
October 2, 2017: European Radiology
https://www.readbyqxmd.com/read/28967326/cerebral-blood-flow-after-mild-traumatic-brain-injury-associations-between-symptoms-and-post-injury-perfusion
#14
Jaclyn A Stephens, Peiying Liu, Hanzang Lu, Stacy J Suskauer
Arterial spin labeling (ASL) has emerged as a technique for assessing mild traumatic brain injury (mTBI), as it can non-invasively evaluate cerebrovascular physiology. To date, there is substantial variability in methodology and findings of ASL studies of mTBI. While both increased and decreased perfusion are reported after mTBI, more consistency is emerging when perfusion is examined with regard to symptomology. We evaluated 15 teenage athletes 2 and 6 weeks after sports-related concussion (SRC group) using pseudo-continuous ASL...
October 1, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28966828/sequential-changes-of-arterial-spin-labeling-perfusion-mr-images-with-dual-postlabeling-delay-following-reconstructive-surgery-for-giant-internal-carotid-artery-aneurysm
#15
Takafumi Shimogawa, Takato Morioka, Tomoaki Akiyama, Sei Haga, Shuji Arakawa, Tetsuro Sayama
BACKGROUND: Arterial spin-labeling magnetic resonance perfusion imaging (ASL-MRI) allows noninvasive measurement of cerebral blood flow (CBF) but depends on arterial transit time (ATT). To overcome this problem, we developed a simple ASL technique with dual postlabeling delay (PLD) settings. In addition to the routinely used PLD of 1.5 seconds, we selected another PLD of 2.5 seconds to assess slowly streaming blood flow and detect arterial transit artifacts (ATAs) resulting from stagnant intravascular magnetically labeled spins...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/28952228/differentiation-between-progression-and-pseudoprogresion-by-arterial-spin-labeling-mri-in-patients-with-glioblastoma-multiforme
#16
Marija Jovanovic, Sandra Radenkovic, Tatjana Stosic-Opincal, Slobodan Lavrnic, Svetlana Gavrilovic, Biljana Lazovic-Popovic, Ivan Soldatovic, Ruzica Maksimovic
PURPOSE: To compare arterial spin labeling (ASL) perfusion technique with the clinically established dynamic susceptibility contrast-enhanced (DSC) perfusion weighted-imaging (PWI), and to determine its value in routine MRI evaluation of disease progression in patients with glioblastoma multiforme (GBM). METHODS: A prospective intraindividual study was performed in 31 patients with histologically proven GBM who had clinical and/or radiological deterioration after treatment, including surgery, radiotherapy and therapy with temozolomide...
July 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/28951369/-test-retest-reliability-of-3d-spiral-fast-spin-echo-pseudo-continuous-arterial-spin-labeling-for-cerebral-perfusion-imaging-of-subcortical-gray-matter-in-healthy-adults
#17
Meng-Qi Liu, Zhi-Ye Chen, Lin Ma
OBJECTIVE: To evaluate the test-retest reliability of 3D spiral fast-spin-echo (FSE) pseudo-continuous arterial spin labeling (3D pc-ASL) for cerebral perfusion imaging of the subcortical gray matter in healthy adults in resting state. METHODS: 3D spiral FSE ASL and 3D T1-weighted fast spoiled gradient recalled echo (3D T1-FSPGR) sequences were used for cerebral perfusion imaging in 8 healthy adult subjects, and a repeat imaging examination was performed after one week...
September 20, 2017: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/28948069/reproducibility-of-quantitative-structural-and-physiological-mri%C3%A2-measurements
#18
Stephen A McGuire, S Andrea Wijtenburg, Paul M Sherman, Laura M Rowland, Meghann Ryan, John H Sladky, Peter V Kochunov
INTRODUCTION: Quantitative longitudinal magnetic resonance imaging and spectroscopy (MRI/S) is used to assess progress of brain disorders and treatment effects. Understanding the significance of MRI/S changes requires knowledge of the inherent technical and physiological consistency of these measurements. This longitudinal study examined the variance and reproducibility of commonly used quantitative MRI/S measurements in healthy subjects while controlling physiological and technical parameters...
September 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28939189/cerebral-blood-flow-velocity-positively-correlates-with-brain-volumes-in-long-term-remitted-depression
#19
Thomas Desmidt, Frédéric Andersson, Bruno Brizard, Jean-Philippe Cottier, Frédéric Patat, Valérie Gissot, Catherine Belzung, Wissam El-Hage, Vincent Camus
BACKGROUND: Mechanisms involved in brain changes observed in major depression have been poorly investigated in clinical populations. Changes in cerebral blood flow (CBF) have been found in depressed patients and constitute a potential mechanism by which brain volume varies in depression. We have tested the association of cerebral blood flow velocity (CBFV) as assessed with Transcranial Doppler (TCD) and cerebral blood flow (CBF) as assessed with Arterial Spin Labeling Magnetic Resonance Imaging (ASL-MRI) with Total Brain Volume (TBV) and the volume of seven subcortical regions, in currently depressed and long-term remitted patients...
September 20, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28937545/non-contrast-pseudo-continuous-arterial-spin-labeling-and-accelerated-3-dimensional-radial-acquisition-intracranial-3-dimensional-magnetic-resonance-angiography-for-the-detection-and-classification-of-intracranial-arteriovenous-shunts
#20
Tilman Schubert, Zachary Clark, Carolina Sandoval-Garcia, Ryan Zea, Oliver Wieben, Huimin Wu, Patrick A Turski, Kevin M Johnson
OBJECTIVES: The aim of this study was to assess the sensitivity and specificity of pseudo-continuous arterial spin labeling (PCASL) magnetic resonance angiography (MRA) with 3-dimensional (3D) radial acquisition for the detection of intracranial arteriovenous (AV) shunts. MATERIALS AND METHODS: A total of 32 patients who underwent PCASL-MRA, clinical magnetic resonance imaging (MRI)/MRA exam, and digital subtraction angiography (DSA) were included in this retrospective analysis...
September 20, 2017: Investigative Radiology
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