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Heart And ( Failure Or Infarction )

J Tromp, W Ouwerkerk, B G Demissei, S D Anker, J G Cleland, K Dickstein, G Filippatos, P van der Harst, H L Hillege, C C Lang, M Metra, L L Ng, P Ponikowski, N J Samani, D J van Veldhuisen, F Zannad, A H Zwinderman, A A Voors, P van der Meer
Aims: We sought to determine subtypes of patients with heart failure (HF) with a distinct clinical profile and treatment response, using a wide range of biomarkers from various pathophysiological domains. Methods and results: We performed unsupervised cluster analysis using 92 established cardiovascular biomarkers to identify mutually exclusive subgroups (endotypes) of 1802 patients with HF and reduced ejection fraction (HFrEF) from the BIOSTAT-CHF project. We validated our findings in an independent cohort of 813 patients...
December 13, 2018: European Heart Journal
Edwin A Li, Wang Xi, Young Soo Han, Frank V Brozovich
The number of patients with heart failure with reduced ejection fraction (HFrEF) and preserved ejection fraction (HFpEF) is increasing, and for HFpEF, no therapies have clinical benefit. It has been hypothesized that PKG attenuates pathological remodelling, and increasing cGMP would be beneficial for patients with HF. However, neither the RELAX nor NEAT-HFpEF trial showed benefit. But there is still enthusiasm for increasing cGMP in patients with HF, which highlight the need to determine the expression of PDEs in cardiac muscle...
December 11, 2018: Archives of Biochemistry and Biophysics
Jae Yeong Cho, Kye Hun Kim, Hyun-Jai Cho, Hae-Young Lee, Jin-Oh Choi, Eun-Seok Jeon, Sang Eun Lee, Min-Seok Kim, Jae-Joong Kim, Kyung-Kuk Hwang, Shung Chull Chae, Sang Hong Baek, Seok-Min Kang, Dong-Ju Choi, Byung-Su Yoo, Youngkeun Ahn, Hyun-Young Park, Myeong-Chan Cho, Byung-Hee Oh
BACKGROUND: We investigated the role of nutritional risk index (NRI) in predicting 1-year mortality in patients with acute decompensated heart failure (ADHF). METHODS: Among 5,625 cohort patients enrolled in Korean Acute Heart Failure (KorAHF) Registry, a total of 5,265 patients who were possible to calculate NRI [NRI = (1.519 x serum albumin [g/dl]) + (41.7 x weight [kg]/ideal body weight [kg])] were enrolled. The patients were divided into 4 groups according to the NRI quartile; Q1 <89 (n = 1121, 69...
2018: PloS One
Aziz Al-Zendani, Adel Al-Emad, Ahmed Al-Motarreb, Mervat Amen, Nora Al-Sagheer, Hana Abu Hadi, Nawar Al-Wather, Hesham Al-Fakeh, Sara Cimino, Luciano Agati
No abstract text is available yet for this article.
December 12, 2018: Journal of Cardiovascular Medicine
Giuseppe Regolisti, Luigi Gerra, Francesca Di Mario, Marco Delsante, Giovani Piotti, Chiara Cantarelli, Giovani Piotti, Santo Morabito, Marco Brambilla, Vincenzo Cantaluppi, Umberto Maggiore, Enrico Fiaccadori
Acute Kidney Injury (AKI) is an important issue for the healthcare system, as it is associated with high mortality and increased risk of readmission, with consequent elevated healthcare resource utilization. We investigated the incidence of AKI based on the examination of the discharge cards of all patients admitted between January 1 2011 and December 31 2015 at the Parma University Hospital, as well as the frequency and type of 30-day hospital readmission in the patients discharged with a first AKI diagnosis (index admission)...
December 2018: Giornale Italiano di Nefrologia: Organo Ufficiale Della Società Italiana di Nefrologia
Michi Recupero, Pierluigi Fulignati, Alessandro Naticchia, Silvia D'Alonzo, Francesca D'Ascenzo, Stefano Costanzi
ADH is a hormone secreted by neurohypophysis that plays different roles based on the target organ. At the renal level, this peptide is capable of causing electrolyte-free water absorption, thus playing a key role in the hydro-electrolytic balance. There are pathologies and disorders that jeopardize this balance and, in this field, ADH receptor inhibitors such as Vaptans could play a key role. By inhibiting the activation pathway of vasopressin, they are potentially useful in euvolemic and hypervolemic hypotonic hyponatremia...
December 2018: Giornale Italiano di Nefrologia: Organo Ufficiale Della Società Italiana di Nefrologia
Josef Stehlik, Brian Armstrong, David A Baran, Nancy D Bridges, Anil Chandraker, Robert Gordon, Teresa De Marco, Michael M Givertz, Alain Heroux, David Iklé, Judson Hunt, Abdallah G Kfoury, Joren C Madsen, Yvonne Morrison, Erika Feller, Sean Pinney, Sudipta Tripathi, Peter S Heeger, Randall C Starling
Clinical Trials in Organ Transplantation-18 (CTOT-18) is a follow-up analysis of the 200-subject multicenter heart transplant CTOT-05 cohort. CTOT-18 aimed to identify clinical, epidemiological and biological markers associated with adverse clinical events past 1 year after transplant. We examined various candidate biomarkers including serum antibodies, angiogenic proteins, blood gene expression profiles and T-cell alloreactivity. The composite endpoint (CE) included death, retransplant, coronary stent, myocardial infarction or cardiac allograft vasculopathy...
December 14, 2018: American Journal of Transplantation
Xinxing Xie, Yunli Shen, Jing Chen, Zheyong Huang, Junbo Ge
The poor survival of stem cells seriously limits their therapeutic efficacy for myocardial infarction (MI). Mineralocorticoid receptor (MR) activation plays an important role in the pathogenesis of multiple cardiovascular diseases. Here, we examined whether MR silencing in bone marrow derived mesenchymal stem cells (MSCs) could improve MSCs' survival and enhance their cardioprotective effects in MI. MSCs from male Sprague-Dawley rats were transfected with adenoviral small interfering RNA to silence MR (siRNA-MR)...
December 13, 2018: Journal of Cellular and Molecular Medicine
Yun Yun Go, Reinhard Sellmair, John C Allen, Anders Sahlén, Heerajnarain Bulluck, David Sim, Fazlur R Jaufeerally, Michael R MacDonald, Zhan Yun Lim, Ping Chai, Seet Yoong Loh, Jonathan Yap, Carolyn S P Lam
AIMS: We aimed to identify a 'frequent admitter' phenotype among patients admitted for acute decompensated heart failure (HF). METHODS AND RESULTS: We studied 10 363 patients in a population-based prospective HF registry (2008-2012), segregated into clusters based on their 3-year HF readmission frequency trajectories. Using receiver-operating characteristic analysis, we identified the index year readmission frequency threshold that most accurately predicts HF admission frequency clusters...
December 13, 2018: European Journal of Heart Failure
Marianna Adamo, Cosmo Godino, Cristina Giannini, Andrea Scotti, Riccardo Liga, Salvatore Curello, Claudia Fiorina, Ermanna Chiari, Giuliano Chizzola, Alessandro Abbenante, Emanuele Visco, Luca Branca, Francesca Fiorelli, Eustachio Agricola, Stefano Stella, Carlo Lombardi, Antonio Colombo, Anna Sonia Petronio, Marco Metra, Federica Ettori
AIMS: To explore whether left ventricular reverse remodelling (LVRR) is a predictor of outcomes in patients with functional mitral regurgitation (FMR) undergoing MitraClip procedure. METHODS AND RESULTS: We analysed 184 consecutive patients with FMR who underwent successful MitraClip procedure. LVRR was defined as a reduction in left ventricular end-systolic volume ≥ 10% from baseline to 6 months. LVRR was observed in 79 (42.9%) patients. Compared with non-LVRR, LVRR patients were more likely to be females, less likely to have an ischaemic aetiology of mitral regurgitation or a prior (<6 months) heart failure (HF) hospitalization, and had smaller left ventricular dimensions...
December 13, 2018: European Journal of Heart Failure
Yen-Chun Lai, Longfei Wang, Mark T Gladwin
Pulmonary hypertension in the setting of heart failure with preserved ejection fraction (PH-HFpEF) is a growing public health problem that is increasing in prevalence. While PH-HFpEF is defined by a high mean pulmonary artery pressure, high left ventricular end-diastolic pressure and a normal ejection fraction, some HFpEF patients develop PH in the presence of pulmonary vascular remodeling with a high transpulmonary pressure gradient or pulmonary vascular resistance. Aging, increased left atrial pressure and stiffness, mitral regurgitation, as well as features of metabolic syndrome, which include obesity, diabetes, and hypertension, are recognized as risk factors for PH-HFpEF...
December 13, 2018: Journal of Physiology
Matthew R Zeglinski, Adel Rezaei Moghadam, Sudharsana R Ande, Kimia Sheikholeslami, Pooneh Mokarram, Zahra Sepehri, Haleh Rokni, Nima Khadem Mohtaram, Mansour Poorebrahim, Anahita Masoom, Mehnosh Toback, Niketa Sareen, Sekaran Saravanan, Davinder S Jassal, Mohammad Hashemi, Hassan Marzban, Dedmer Schaafsma, Pawan Singal, Jeffrey T Wigle, Michael P Czubryt, Mohsen Akbari, Ian M C Dixon, Saeid Ghavami, Joseph W Gordon, Sanjiv Dhingra
Cardiovascular disease leading to heart failure (HF) remains a leading cause of morbidity and mortality worldwide. Improved pharmacological and interventional coronary procedures have led to improved outcomes following acute myocardial infarction. This success has translated into an unforeseen increased incidence in HF. This review summarizes the signaling pathways implicated in the transition to HF following cardiac injury. In addition, we provide an update on cell death signaling and discuss recent advances in cardiac fibrosis as an independent event leading to HF...
December 13, 2018: Comprehensive Physiology
Ke Huang, Shiqi Hu, Ke Cheng
Myocardial infarction (MI), caused by coronary heart disease (CHD), remains one of the most common causes of death in the United States. Over the last few decades, scientists have invested considerable resources on the study and development of cell therapies for myocardial regeneration after MI. However, due to a number of limitations, they are not yet readily available for clinical applications. Mounting evidence supports the theory that paracrine products are the main contributors to the regenerative effects attributed to these cell therapies...
December 13, 2018: Advanced Healthcare Materials
Francesc Formiga, Rafael Moreno-Gonzalez, David Chivite, Sergi Yun, Jonathan Franco, Albert Ariza-Solé, Xavier Corbella
AIM: To assess whether 1-year mortality in older patients experiencing a first admission for acute heart failure was related to sex, and to explore differential characteristics according to sex. METHODS: We reviewed the medical records of 1132 patients aged >70 years of age admitted within a 3-year period because of a first episode of acute heart failure. We analyzed sex differences. Mortality was assessed using multivariate Cox analysis. RESULTS: There were 648 (57...
December 12, 2018: Geriatrics & Gerontology International
Mark V Sherrid, Katherine Riedy, Barry Rosenzweig, Monica Ahluwalia, Milla Arabadjian, Muhamed Saric, Sandhya Balaram, Daniel G Swistel, Harmony R Reynolds, Bette Kim
BACKGROUND: Acute left ventricular (LV) apical ballooning with normal coronary angiography occurs rarely in obstructive hypertrophic cardiomyopathy (OHCM); it may be associated with severe hemodynamic instability. METHODS, RESULTS: We searched for acute LV ballooning with apical hypokinesia/akinesia in databases of two HCM treatment programs. Diagnosis of OHCM was made by conventional criteria of LV hypertrophy in the absence of a clinical cause for hypertrophy and mitral-septal contact...
December 12, 2018: Echocardiography
Nermin S Ahmed
Hit, Lead & Candidate Discovery Tadalafil, Cialis, Eli Lilly & Co./ICOS, (6R,12aR)-6-(1,3-benzodioxol-5-yl)-2-methyl-2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6] pyrido[3,4-b]indole-1,4-dione, was first discovered in 2003. It was reported to have high diastereospecificity for phosphodiesterase 5 (PDE5) inhibitions. The cis-(6R, 12aR) enantiomer is the most active enantiomer. Tadalafil showed PDE5 inhibition with IC50  = 5 nM. It possesses high selectivity for PDE5 versus PDE1-4 and PDE6. Tadalafil is more selective to PDE5 against PDE6 whereas sildenafil, another commercially available PDE5 inhibitor shows similar potencies to inhibit PDE5 and PDE6...
December 13, 2018: Drug Development Research
Zheng-Yu Liu, Hong-Wei Pan, Yan Cao, Jiao Zheng, Yu Zhang, Yi Tang, Jin He, Yong-Jun Hu, Chang-Lu Wang, Qiong-Chao Zou, Qing-Hua Fu, Le Zhang, Jian-Qiang Peng, Jing Ling, Ning Peng, Jing-Jing Rong, Zhao-Fen Zheng
microRNAs (miRs) are essential in the development of heart failure. The aim of this study is to investigate the effect of microRNA-330 (miR-330) on left ventricular remodeling via the TGF-β1/Smad3 signaling pathway by targeting the sex-determining region Y (SRY) in mice with myocardial ischemia-reperfusion injury (MIRI). Differentially expressed gene (DEG) in myocardial ischemia-reperfusion (IR) was screened out and the miR that targeted the DEG was also predicted and verified. A model of MIRI was established to detect the expression of miR-330, SRY, transforming growth factor-β (TGF-β1), and Sekelsky mothers against dpp3 (Smad3)...
December 12, 2018: Journal of Cellular Physiology
Saiko Mizumi, Ayumi Goda, Kaori Takeuchi, Hanako Kikuchi, Takumi Inami, Kyoko Soejima, Toru Satoh
Cardiopulmonary exercise testing (CPX) with right heart catheterization (RHC) widely used for early diagnosis and evaluation of pulmonary vascular disease in patients with pulmonary arterial hypertension and early stage heart failure with preserved ejection fraction, who display normal hemodynamics at rest. The aim of this study was to investigate that whether body position affects pulmonary hemodynamics, pulmonary arterial wedge pressure (PAWP), and CPX parameters during invasive CPX. Seventeen patients (58 ± 14 years; 5/12 male/female) with chronic thromboembolic pulmonary hypertension treated with percutaneous transluminal pulmonary angioplasty and near-normal pulmonary artery pressure (PAP) underwent invasive CPX twice in supine and upright position using a cycle ergometer with 6 months interval...
December 2018: Physiological Reports
Zulong Sheng, Wenbin Lu, Zhi Zuo, Dong Wang, Pengfei Zuo, Yuyu Yao, Genshan Ma
OBJECTIVE: MicroRNAs (miRNAs) have been shown to play crucial roles in the occurrence, development, and treatment of many cardiovascular diseases. Coronary heart disease (CAD)-related miRNAs are still a growing research area. miR-7b was reported to be downregulated in acute myocardial infarction (AMI) myocardium tissues. However, it remains largely unknown whether miR-7b is involved in the pathogenesis and progression of the AMI ischemia/reperfusion (I/R) injury. METHODS: Male C57BL/6 J mice and H9C2 cells were used as models in this study...
December 11, 2018: Journal of Cellular Biochemistry
Yin Yee Leong, Wai Hoe Ng, Mimi Zulaikha Umar Fuaad, Chin Theng Ng, Rajesh Ramasamy, Vuanghao Lim, Yoke Keong Yong, Jun Jie Tan
Stem cell therapy offers hope to reconstitute injured myocardium and salvage heart from failing. A recent approach using combinations of derived Cardiac-derived c-kit expressing cells (CCs) and mesenchymal stem cells (MSCs) in transplantation improved infarcted hearts with a greater functional outcome, but the effects of MSCs on CCs remain to be elucidated. We used a novel two-step protocol to clonogenically amplify colony forming c-kit expressing cells from 4- to 6-week-old C57BL/6N mice. This method yielded highly proliferative and clonogenic CCs with an average population doubling time of 17...
December 11, 2018: Journal of Cellular Biochemistry
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