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Heart And ( Failure Or Infarction )

Adina Elena Stanciu, Marcel Marian Stanciu, Radu Gabriel Vatasescu
PURPOSE: Heart failure (HF) is considered to be a complex syndrome associated with neurohormonal and cytokine activation, that contribute to its progression. There are evidences which showed that, carbohydrate antigen 125 (CA 125), a tumor marker widely used for ovarian cancer therapy monitoring, was significantly elevated in HF patients. We hypothesized that inflammatory stimuli may be responsible for amino-terminal fragment of the prohormone B-type natriuretic peptide (NT-proBNP) and CA-125 production and release in chronic HF (CHF)...
August 8, 2018: Cytokine
Marat Fudim, Wayne L Miller
BACKGROUND: Calculated estimates of plasma volume (PV) have been developed using hemoglobin/hematocrit-body weight based methods. The accuracy of such formula-derived values has not been thoroughly evaluated. The objective of this analysis is the comparison of calculated vs. a quantitative measure of PV in patients with chronic heart failure (HF). METHODS: PV was measured using a standardized computer-based indicator-dilution labelled albumin technique in 110 patients with clinically stable chronic HF and correlated with paired Kaplan-Hakim (K-H) and Strauss formula estimates of PV...
August 8, 2018: Journal of Cardiac Failure
Yi Gao, Yichao Zhao, Ancai Yuan, Longwei Xu, Xian Huang, Yuanyuan Su, Lingchen Gao, Qingqi Ji, Jun Pu, Ben He
Myocardial ischemia/reperfusion (MI/R) injury induces excessive cellular apoptosis and contributes significantly to final infarct size. We previously demonstrated that a nuclear receptor, Farnesoid X receptor (FXR), plays a crucial role in mediating myocardial apoptosis. The FXR functions are regulated by post translational modifications (PTM). However, whether the proapoptotic effect of FXR in MI/R injury is regulated by PTM remains unclear. Here, we aimed to study the effect of SUMOylation, a PTM involved in the pathogenesis of MI/R injury per se, on the proapoptotic effect of FXR in MI/R injury...
August 8, 2018: Experimental Cell Research
T Kotwica, J Relewicz, A Rojek, M Tupikowska-Marzec, M Kabaj, B Karolko, J Maj, G Bednarek-Tupikowska, W Kosmala, J C Szepietowski, M Przewlocka-Kosmala
BACKGROUND: Psoriasis has been shown to increase cardiovascular risk, and a contributor to this might be enhanced myocardial fibrosis promoted by the disease-associated proinflammatory milieu. OBJECTIVE: We sought to investigate the relationship of galectin-3 (Gal-3) - a recognized mediator of fibrosis with inflammatory activation and left ventricular (LV) systolic and diastolic function in patients with psoriasis. METHODS: We enrolled 102 psoriatic patients (mean age: 52...
August 11, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
Ketul R Chaudhary, Yupu Deng, Colin M Suen, Mohamad Taha, Thomas H Petersen, Shirley H J Mei, Duncan J Stewart
BACKGROUND AND PURPOSE: Pulmonary arterial hypertension (PAH) is a life-threatening disease that leads to progressive pulmonary hypertension, right heart failure and death. Parenteral prostaglandins, including treprostinil, a prostacyclin analogue, represent the most effective medical treatment for severe PAH. We investigated the effect of treprostinil on established severe PAH and underlying mechanisms using the rat SU5416 (SU, a vascular endothelial growth factor receptor-2 inhibitor)-chronic hypoxia (Hx) model of PAH...
August 11, 2018: British Journal of Pharmacology
Ying Cao, Shujun Chen, Yemei Liang, Ting Wu, Jianxin Pang, Shuwen Liu, Pingzheng Zhou
BACKGROUND AND PURPOSE: Carvedilol is a clinically broadly used and effective beta-blocker for treatment of congestive heart failure (CHF) and several clinical trials have demonstrated that carvedilol shows a favourable effect compared to other beta-blocking agents in patients with CHF. The mechanism underlying the advantage of carvedilol over other beta-blocking agents is not clearly understood. In addition to beta-blockers, inhibitors of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, which play a critical role in spontaneous rhythmic activity in the heart, have also been proposed to be suitable in reducing the heart rate and therefore beneficial for treatment of CHF...
August 10, 2018: British Journal of Pharmacology
Yoshiaki Kubota, Takeshi Yamamoto, Shuhei Tara, Yukichi Tokita, Kenji Yodogawa, Yuki Iwasaki, Hitoshi Takano, Yayoi Tsukada, Kuniya Asai, Masaaki Miyamoto, Yasushi Miyauchi, Eitaro Kodani, Naoki Sato, Jun Tanabe, Wataru Shimizu
INTRODUCTION: Protection from lethal ventricular arrhythmias leading to sudden cardiac death is one of the most important problems after myocardial infarction. Cardiac sympathetic hyperactivity is related to poor prognosis and fatal arrhythmias and can be non-invasively assessed with heart rate variability, heart rate turbulence, T-wave alternans, late potentials, and 123 I-meta-iodobenzylguanide (123 I-MIBG) scintigraphy. Sodium glucose cotransporter 2 (SGLT2) inhibitors potentially reduce sympathetic nervous system activity that is augmented in part due to the stimulatory effect of hyperglycemia...
August 10, 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
Syed Yaseen Naqvi, Anas Jawaid, Ilan Goldenberg, Valentina Kutyifa
PURPOSE OF REVIEW: Cardiac resynchronization therapy (CRT) is an effective treatment option for therapy-refractory mild to severe heart failure (HF) patients with reduced ejection fraction and left ventricular (LV) conduction delay. Multiple clinical trials have shown that CRT improves cardiac function and overall quality of life, as well as reduces HF hospitalizations, health care costs, and mortality. RECENT FINDINGS: Despite its effectiveness, the "non-response" rate to CRT is around 30%, remaining a major challenge that faces electrophysiologists and researchers...
August 10, 2018: Current Heart Failure Reports
Karine Luz Londoño, Francesc Formiga, David Chivite, Rafael Moreno-Gonzalez, Margherita Migone De Amicis, Xavier Corbella
In the original publication, the given name and family name of the fifth author Dr Margherita Migone De Amicis were incorrectly published. The correct given name and family name should read as 'Margherita' and 'Migone De Amicis', respectively.
August 10, 2018: Internal and Emergency Medicine
Edward D Coverstone, Richard G Bach, LiShiun Chen, Laura J Bierut, Allie Y Li, Petra A Lenzini, Heidi C O'Neill, John A Spertus, Carmen C Sucharov, Jerry A Stitzel, Joel D Schilling, Sharon Cresci
The CHRNA5 gene encodes a neurotransmitter receptor subunit involved in multiple processes, including cholinergic autonomic nerve activity and inflammation. Common variants in CHRNA5 have been linked with atherosclerotic cardiovascular disease. Association of variation in CHRNA5 and specific haplotypes with cardiovascular outcomes has not been described. The aim of this study was to examine the association of CHRNA5 haplotypes with gene expression and mortality among patients with acute myocardial infarction (AMI) and explore potential mechanisms of this association...
August 10, 2018: Basic Research in Cardiology
Sven M Piepenburg, Hermann Faller, Stefan Störk, Georg Ertl, Christiane E Angermann
BACKGROUND: Depression is more common in females than in males and is 3-5 times more prevalent in patients with heart failure (HF) than in the general population. The 9-item Patient Health Questionnaire (PHQ-9) is a validated depression screening instrument; higher sum-scores predict adverse clinical outcomes. Sex- and gender differences in PHQ-9 symptom profile, diagnostic and prognostic properties, and impact on health-related quality of life (HRQOL) have not been comprehensively studied in HF patients...
August 10, 2018: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
Jun Seong Lee, Se-Jin Jeong, Sinai Kim, Lorraine Chalifour, Tae Jin Yun, Mohammad Alam Miah, Bin Li, Abdelilah Majdoubi, Antoine Sabourin, Tibor Keler, Jean V Guimond, Elie Haddad, Eui-Young Choi, Slava Epelman, Jae-Hoon Choi, Jacques Thibodeau, Goo Taeg Oh, Cheolho Cheong
Ischemic myocardial injury results in sterile cardiac inflammation that leads to tissue repair, two processes controlled by mononuclear phagocytes. Despite global burden of cardiovascular diseases, we do not understand the functional contribution to pathogenesis of specific cardiac mononuclear phagocyte lineages, in particular dendritic cells. To address this limitation, we used detailed lineage tracing and genetic studies to identify bona fide murine and human CD103+ conventional dendritic cell (cDC)1s, CD11b+ cDC2s, and plasmacytoid DCs (pDCs) in the heart of normal mice and immunocompromised NSG mice reconstituted with human CD34+ cells, respectively...
August 10, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
Deborah Mueller, Christian Puelacher, Ursina Honegger, Joan E Walter, Patrick Badertscher, Nicolas Schaerli, Ivo Strebel, Raphael Twerenbold, Jasper Boeddinghaus, Thomas Nestelberger, Christina Hollenstein, Jeanne du Fay de Lavallaz, Raban Jeger, Christoph Kaiser, Damian Wild, Katharina Rentsch, Andreas Buser, Michael Zellweger, Tobias Reichlin, Christian Mueller
BCKGROUND: We aimed to directly compare high-sensitivity cardiac troponin I (hs-cTnI) and high-sensitivity cardiac troponin T (hs-cTnT) in the detection of functionally relevant coronary artery disease (fCAD). METHODS: Consecutive patients referred with clinical suspicion of fCAD and no structural heart disease other than coronary artery disease were included. The presence of fCAD was based on rest/stress myocardial perfusion single-photon emission computed tomography/computed tomography and coronary angiography...
August 10, 2018: Clinical Chemistry
Agnieszka Pawlak, Emilia Rejmak-Kozicka, Katarzyna Elżbieta Gil, Andrzej Ziemba, Leszek Kaczmarek, Robert Julian Gil
Desmin expression depends on desmin messenger RNA (mRNA) and ubiquitin proteasome system. This process is poorly understood in dilated cardiomyopathy. The aim of the study was to investigate whether changes of desmin mRNA and ubiquitin expression correlate with types of desmin expression in cardiomyocytes. Endomyocardial biopsy was performed in 60 patients (85% men, mean age 46±14 years) with heart failure (HF; left ventricular ejection fraction <45%). Desmin and ubiquitin expression were analysed in histological sections by immunohistochemistry and in Western blot...
August 10, 2018: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
Zach Rozenbaum, Yan Topilsky, Shafik Khoury, David Pereg, Michal Laufer-Perl
BACKGROUND: Small scale cohorts demonstrated an association between body mass index (BMI) and diastolic function in a metabolically healthy population. We aimed to characterize the relation between BMI and diastolic function in a relatively large cohort of metabolically healthy obese with preserved ejection fraction. METHODS AND RESULTS: Echocardiograms of metabolically healthy patients between 2011 and 2016, who had no significant valvulopathies or atrial fibrillation, and had preserved ejection fraction, were retrospectively identified and analyzed...
August 4, 2018: International Journal of Cardiology
Sandhir B Prasad, Andrew K Lin, Kristyan B Guppy-Coles, Tony Stanton, Rathika Krishnasamy, Gillian A Whalley, Liza Thomas, John J Atherton
BACKGROUND: Recent American Society of Echocardiography and European Association of Cardiovascular Imaging guidelines for the assessment of diastolic dysfunction (DD) recommend a simplified approach with four key variables incorporated into a novel diagnostic algorithm. The aim of this study was to assess the prognostic value of significant DD assessed using the algorithm recommended in the 2016 American Society of Echocardiography and European Association of Cardiovascular Imaging guidelines (DD2016) in comparison with the prognostic value of significant DD assessed using the 2009 guidelines (DD2009) as well as the individual parameters incorporated in the 2016 algorithm...
August 7, 2018: Journal of the American Society of Echocardiography
Sandra Korol, Michel White, Eileen O'Meara, François Tournoux, Normand Racine, Anique Ducharme, Jean-Lucien Rouleau, Mark Liszkowski, Asmaa Mansour, Martin Jutras, Marie-Claude Guertin, Mathieu Bernier, Joël Lavoie, Grégoire Leclair, Paul-Eduard Neagoe, Diana Chaar, Martin G Sirois, Simon de Denus
Mineralocorticoid receptor antagonists (MRAs) decrease morbidity and mortality in patients with heart failure (HF). However, spironolactone, a non-selective MRA, has been shown to exert a harmful effect on glucose homeostasis. The objective of this multicenter, randomized, controlled, double-blind trial was to compare the effects of spironolactone to those of the selective MRA eplerenone on glucose homeostasis among 62 HF patients with glucose intolerance or type II diabetes. TRIAL REGISTRATION NUMBER: NCT01586442...
July 10, 2018: American Heart Journal
Yu Wang, Jian Li, Liying Xuan, Yongfeng Liu, Liqun Shao, Hongyan Ge, Junyi Gu, Chengxi Wei, Ming Zhao
BACKGROUND: Viral myocarditis is defined as viral infection of myocardial tissue leading to impaired heart function and heart failure. Accumulating evidences have shown that arrhythmia is one of important complicating diseases of viral myocarditis causing increased mortality and morbidity. There are no effective treatment for the viral infection and complicating arrhythmia. PURPOSE: This study investigated the effect and mechanism of Astragalus Root dry extract (ARDE) on arrhythmia induced by CVB3 in mice...
July 15, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
Julia Ruhe, Christoph Waldeyer, Francisco Ojeda, Alev Altay, Renate B Schnabel, Sarina Schäfer, Karl J Lackner, Stefan Blankenberg, Tanja Zeller, Mahir Karakas
Intrinsic iron release is discussed to have favorable effects in coronary artery disease (CAD). The aim of this study was to evaluate the prognostic relevance of intrinsic iron release in patients with CAD. Intrinsic iron release was based on a definition including hepcidin and soluble transferrin receptor (sTfR). In a cohort of 811 patients with angiographically documented CAD levels of hepcidin and sTfR were measured at baseline. Systemic body iron release was defined as low levels of hepcidin (<24 ng/mL) and high levels of sTfR (≥2 mg/L)...
August 9, 2018: Biomolecules
Pauline V Marck, Sandrine V Pierre
The first reports of cardiac Na/K-ATPase signaling, published 20 years ago, have opened several major fields of investigations into the cardioprotective action of low/subinotropic concentrations of cardiotonic steroids (CTS). This review focuses on the protective cardiac Na/K-ATPase-mediated signaling triggered by low concentrations of ouabain and other CTS, in the context of the enduring debate over the use of CTS in the ischemic heart. Indeed, as basic and clinical research continues to support effectiveness and feasibility of conditioning interventions against ischemia/reperfusion injury in acute myocardial infarction (AMI), the mechanistic information available to date suggests that unique features of CTS-based conditioning could be highly suitable, alone /or as a combinatory approach...
August 9, 2018: International Journal of Molecular Sciences
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