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Heart And ( Failure Or Infarction )

Geir Hirlekar, Martin Jonsson, Thomas Karlsson, Jacob Hollenberg, Per Albertsson, Johan Herlitz
BACKGROUND: Patients suffering out-of-hospital cardiac arrest (OHCA) have a poor prognosis but survival among subgroups differs greatly. Previous studies have shown conflicting results on whether patient comorbidity affects outcome. The aim of this national study was to investigate the effect of comorbidity on outcome after OHCA in Sweden. METHODS: We included all patients with bystander-witnessed OHCA from 2011‒2015 in the national Swedish Registry of Cardiopulmonary Resuscitation...
October 10, 2018: Resuscitation
Mohammed Al-Jarallah, Rajesh Rajan, Ibrahim Al-Zakwani, Raja Dashti, Bassam Bulbanat, Kadhim Sulaiman, Alawi A Alsheikh-Ali, Prashanth Panduranga, Khalid F AlHabib, Jassim Al Suwaidi, Wael Al-Mahmeed, Hussam AlFaleh, Abdelfatah Elasfar, Ahmed Al-Motarreb, Mustafa Ridha, Nooshin Bazargani, Nidal Asaad, Haitham Amin
AIMS: This study aims to evaluate the incidence and impact of cardiorenal anaemia syndrome (CRAS) on all-cause mortality in acute heart failure (AHF) patients stratified by left ventricular ejection fraction (LVEF) status in the Middle East. METHODS AND RESULTS: Data were analysed from 4934 consecutive patients admitted to 47 hospitals in seven Middle Eastern countries (Saudi Arabia, Oman, Yemen, Kuwait, United Arab Emirates, Qatar, and Bahrain) with AHF from February to November 2012...
October 12, 2018: ESC Heart Failure
Yun Shen, Lizheng Shi, Elizabeth Nauman, Peter T Katzmarzyk, Eboni G Price-Haywood, Ping Yin, Alessandra N Bazzano, Somesh Nigam, Gang Hu
BACKGROUND: Studies on racial differences in diabetic complications are very limited. The objective of this study was to investigate the race and sex differences in diabetic complications between African Americans and whites with type 2 diabetes in Louisiana. METHODS: We performed a prospective cohort study of 27,113 African Americans and 40,431 whites with type 2 diabetes who were 35-95 years of age from three health care systems located in South Louisiana. Four major diabetic complications were assessed including coronary heart disease (CHD), heart failure, stroke, and end-stage renal disease (ESRD)...
October 13, 2018: Journal of Diabetes
Manu M Mysore, Kenneth C Bilchick, Priscilla Ababio, Benjamin K Ruth, William C Harding, Khadijah Breathett, Kimberley Chadwell, Brandy Patterson, Hunter Mwansa, Christiana M Jeukeng, Younghoon Kwon, Jamie L W Kennedy, Andrew D Mihalek, Sula Mazimba
BACKGROUND: Pulmonary hypertension (PH) is characterized by increased pulmonary vascular resistance leading to right heart failure. Elevated right atrial (RA) pressure reflects right ventricular (RV) pressure overload and is an established risk factor for mortality in PH. We hypothesized that PH patients with an increased ratio of RA to LA volume index (RAVI/LAVI), would have increased mortality. METHODS: We evaluated the association of RAVI/LAVI with mortality in 124 patients seen at a single academic center's PH clinic after adjusting for the REVEAL risk score, an established risk score in PH...
October 12, 2018: Echocardiography
Hidekatsu Fukuta, Toshihiko Goto, Kazuaki Wakami, Takeshi Kamiya, Nobuyuki Ohte
Left ventricular (LV) diastolic dysfunction is associated with the pathophysiology of heart failure with preserved ejection fraction (HFpEF) and contributes importantly to exercise intolerance that results in a reduced quality of life (QOL) in HFpEF patients. Experimental studies have shown that aldosterone plays a role in the genesis of myocardial hypertrophy and fibrosis, thereby enhancing LV diastolic dysfunction, and that aldosterone antagonists (mineralocorticoid receptor antagonists [MRAs]) prevents myocardial hypertrophy and fibrosis...
October 12, 2018: Heart and Vessels
Chrishan J Nalliah, Prashanthan Sanders, Jonathan M Kalman
PURPOSE OF REVIEW: Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia in humans, affecting more than 33 million people globally. Its association with complex, resource intensive medical conditions such as stroke, heart failure and dementia have had profound impacts across existing health care structures. The global prevalence of AF has enjoyed significant growth despite significant improvement in our armamentarium for arrhythmia treatment. RECENT FINDINGS: Efforts aimed at curtailing the incidence, prevalence, or progression of AF have prompted re-evaluation of traditional frameworks for understanding and managing this debilitating disease...
October 12, 2018: Current Cardiology Reports
Shu-Jun Chen, Yao Xu, Ye-Mei Liang, Ying Cao, Jin-Yan Lv, Jian-Xin Pang, Ping-Zheng Zhou
Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels play a critical role in controlling pacemaker activity in both heart and nervous system. Developing HCN channel inhibitors has been proposed to be an important strategy for the treatment of pain, heart failure, arrhythmias, and epilepsy. One HCN channel inhibitor, ivabradine, has been clinically approved for the treatment of angina pectoris and heart failure. In this study, we designed and synthesized eight alkanol amine derivatives, and assessed their effects on HCN channels expressed in COS7 cells using a whole-cell patch clamp method...
October 12, 2018: Acta Pharmacologica Sinica
Bhairab N Singh, Naoko Koyano-Nakagawa, Wuming Gong, Ivan P Moskowitz, Cyprian V Weaver, Elizabeth Braunlin, Satyabrata Das, Jop H van Berlo, Mary G Garry, Daniel J Garry
The mammalian heart has a limited regenerative capacity and typically progresses to heart failure following injury. Here, we defined a hedgehog (HH)-Gli1-Mycn network for cardiomyocyte proliferation and heart regeneration from amphibians to mammals. Using a genome-wide screen, we verified that HH signaling was essential for heart regeneration in the injured newt. Next, pharmacological and genetic loss- and gain-of-function of HH signaling demonstrated the essential requirement for HH signaling in the neonatal, adolescent, and adult mouse heart regeneration, and in the proliferation of hiPSC-derived cardiomyocytes...
October 12, 2018: Nature Communications
Leonardo Jönck Staub, Roberta Rodolfo Mazzali Biscaro, Erikson Kaszubowski, Rosemeri Maurici
BACKGROUND: Lung ultrasound can accelerate the diagnosis of life-threatening diseases in adults with respiratory symptoms. OBJECTIVE: Systematically review the accuracy of lung ultrasonography (LUS) for emergency diagnosis of pneumonia, acute heart failure, and exacerbation of chronic obstructive pulmonary disease (COPD)/asthma in adults. METHODS: PubMed, Embase, Scopus, Web of Science, and LILACS (Literatura Latino Americana e do Caribe em Ciências da Saúde; until 2016) were searched for prospective diagnostic accuracy studies...
October 9, 2018: Journal of Emergency Medicine
Essam M Mahfouz
No abstract text is available yet for this article.
October 6, 2018: International Journal of Cardiology
Maria Jose Soler, Montserrat Batlle, Marta Riera, Begoña Campos, José Tomás Ortiz-Perez, Lidia Anguiano, Heleia Roca-Ho, Marta Farrero, Lluis Mont, Julio Pascual, Felix Perez-Villa
OBJECTIVES: The authors sought to evaluate cardiac activity of angiotensin-converting enzyme (ACE) and ACE2 after heart transplantation (HT) and its relation with acute rejection (AR) and chronic allograft vasculopathy (CAV). BACKGROUND: The renin-angiotensin system is altered in heart failure and HT. However, ACE and ACE2 activities in post-HT acute and chronic rejection have not been previously studied. METHODS: HT patients (n = 45) were included when appropriate serial endomyocardial biopsies (EMB) and coronary angiography were available for analysis...
October 3, 2018: International Journal of Cardiology
Abigail Quintos, Mario Naranjo, Colleen Kelly, Stuart F Quan, Sunil Sharma
PURPOSE: The HoSMed Database recently demonstrated a high prevalence of obstructive sleep apnea (OSA) in hospitalized obese patients. Based on a long-term follow-up, this study showed an improved survival among patients who were adherent with the therapy. In this post-hoc analysis we explore the characteristics, associations, and mortality outcome of OSA in the African American (AA) population. METHODS: These subset analyses included obese AA patients screened in the hospital as high-risk for OSA...
October 9, 2018: Journal of the National Medical Association
Andreas Roos, Ulrik Sartipy, Rickard Ljung, Martin J Holzmann
The prognosis in patients with chest pain and chronic myocardial injury compared with patients with non-ST-segment elevation myocardial infarction (NSTEMI) is unknown. This study aims to investigate differences in long-term outcomes. Patients with chest pain at Karolinska University Hospital, Sweden from 2011 to 2014, who had stable high-sensitivity cardiac troponin T (hs-cTnT) levels were compared with patients with NSTEMI. We estimated hazard ratios with 95% confidence intervals for the risk of all-cause mortality, myocardial infarction, and heart failure at different hs-cTnT levels using patients with NSTEMI as referent...
September 15, 2018: American Journal of Cardiology
Carlos Ortiz-Bautista, Laura Morán-Fernández, Marta Díaz-García, Miguel Ángel Delgado-Nicolás, Inés Ponz-de Antonio, Adriana Rodríguez-Chaverri, Mª Dolores García-Cosio, Javier de Juan-Bagudá, David Lora-Pablos, Violeta Sánchez-Sánchez, Pilar Escribano-Subías, Héctor Bueno, Fernando Arribas-Ynsaurriaga, Juan F Delgado-Jiménez
BACKGROUND AND OBJECTIVE: Several trials have evaluated the effect of disease management programs in heart failure (HF) with diverse results. The aim of this study was to develop a simple nurse-led clinic intervention program for patients with HF and assess whether this intervention positively affects the prognosis of patients, their care costs and perceived quality of life (QoL). METHODS: Between 2011 and 2013, 127 patients with reduced ejection fraction were prospectively randomly allocated (1:2) to standard care or intervention program...
October 9, 2018: Medicina Clínica
D Thomas, F Paillard, J M Lecerf, F Carré
The behavioral goals of the coronary patient require active management by the cardiologist. Every smoker must be clearly informed about the cardiovascular consequences of smoking and the major benefits of smoking cessation. The only advice to "quit smoking" is not enough. Validated "treatments" (cognitive-behavioral therapy, nicotine replacement therapy, varenicline, bupropion) must be used, with a precise strategy and prolonged follow-up. All drugs assistance can be prescribed in coronary patients and nicotine replacement therapy can even be used just after a myocardial infarction...
October 9, 2018: Annales de Cardiologie et D'angéiologie
Christopher S Lee, Quin E Denfeld, Bradley E Aouizerat, Corrine Y Jurgens, Christopher V Chien, Emily Aarons, Jill M Gelow, Shirin O Hiatt, James O Mudd
BACKGROUND: We have a limited understanding of the biological underpinnings of symptoms in heart failure (HF). OBJECTIVES: The purpose of this paper was to compare relationships between peripheral biomarkers of HF pathogenesis and physical symptoms between patients with advanced versus moderate HF. METHODS: This was a two-stage phenotype sampling cohort study wherein we examined patients with advanced HF undergoing ventricular assist device implantation in the first stage, and then patients with moderate HF (matched adults with HF not requiring device implantation) in the second stage...
October 9, 2018: Heart & Lung: the Journal of Critical Care
Man Li, Yao Wu, Yao-Hua Tian, Ya-Ying Cao, Jing Song, Zhe Huang, Xiao-Wen Wang, Yong-Hua Hu
There is little evidence that acute exposure to fine particulate matter (PM2.5 ) impacts the rate of hospitalization for congestive heart failure (CHF) in developing countries. The primary purpose of the present retrospective study was to evaluate the short-term association between ambient PM2.5 and hospitalization for CHF in Beijing, China. A total of 15,256 hospital admissions for CHF from January 2010 to June 2012 were identified from Beijing Medical Claim Data for Employees and a time-series design with generalized additive Poisson model was used to assess the obtained data...
October 11, 2018: International Journal of Environmental Research and Public Health
Xiaoyu Zheng, Weijin Zheng, Bo Xiong, Jing Huang
BACKGROUND: Several randomized controlled trials (RCTs) have been investigated the benefits of soluble guanylate cyclase (sGC) stimulators in the treatment of heart failure, but a comprehensive evaluation is lacking. We performed a meta-analysis to evaluate the efficacy and safety of oral sGC stimulators (vericiguat and riociguat) in patients with heart failure. METHODS: Studies were searched and screened in PubMed, Embase, and Cochrane Library. Eligible RCTs were included that reported mortality, the change of EuroQol Group 5-Dmensional Self-report Questionnaire (EQ-5D) US index, N-terminal pro-B-type natriuretic peptide (NT-proBNP), or serious adverse events (SAEs)...
October 2018: Medicine (Baltimore)
Jianxin Chen, Junhui Wang
BACKGROUND: The present comparative meta-analysis was conducted to evaluate the cardiovascular events of regorafenib in patients with solid tumors. METHODS: Eligible studies from MEDLINE, Google Scholar, Cochrane Library, Clinical key, EBSCO publishing and Ovid, which had reported cardiovascular adverse events potentially caused by regorafenib were absorbed. Data of clinical characteristics and cardiovascular events including hypertension, hemorrhage, thrombosis, and heart failure were extracted from selected literatures for the final analysis...
October 2018: Medicine (Baltimore)
Gang Wang, Wei-Gang Cao, Tian-Lan Zhao
Tumescent anesthesia makes it feasible to perform liposuction in an office setting. There are often patients who desire extensive liposuction on approximately 30% of total body surface area, which means the potential of fluid overload. In this study, the charts of 83 patients undergoing extensive liposuction were retrospectively reviewed. The intra-operative fluid ratio was 1.66 for the extensive liposuction. There were no episodes of pulmonary edema, congestive heart failure exacerbation, or other major complications...
October 2018: Medicine (Baltimore)
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