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Conversion gastric cancer

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https://www.readbyqxmd.com/read/30106095/tumor-promoter-role-of-mir%C3%A2-647-in-gastric-cancer-via-repression-of-tp73
#1
Xiangqian Zhang, Min Zhang, Guifeng Wang, Ye Tian, Xiaolong He
It has previously been demonstrated that miRNA (miR)‑647 exhibits an important role in various cancers, and is aberrantly expressed in gastric cancer (GC). However, the exact role of miR‑647 in GC still remains unclear. The present study aimed to investigate the functional significance of miR‑647 and its target gene in GC. TargetScan and Miranda databases were used to predict the putative targets, and the prediction was validated by Dual‑luciferase Reporter Assays. To investigate whether miR‑647 affects GC cell behavior, a stable miR‑647‑overexpression/low‑expression cell line was generated by transfection with miR‑647 mimic/inhibitor...
August 6, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/30096805/pectolinarigenin-induced-cell-cycle-arrest-autophagy-and-apoptosis-in-gastric-cancer-cell-via-pi3k-akt-mtor-signaling-pathway
#2
Ho Jeong Lee, Venu Venkatarame Gowda Saralamma, Seong Min Kim, Sang Eun Ha, Suchismita Raha, Won Sup Lee, Eun Hee Kim, Sang Joon Lee, Jeong Doo Heo, Gon Sup Kim
Pectolinarigenin (PEC), a natural flavonoid present in Cirsium chanroenicum and in some species of Citrus fruits, has various pharmacological benefits such as anti-inflammatory and anti-cancer activities. In the present study, we investigated the anti-cancer mechanism of PEC induced cell death caused by autophagy and apoptosis in AGS and MKN28 human gastric cancer cells. The PEC treatment significantly inhibited the AGS and MKN28 cell growth in a dose-dependent manner. Further, PEC significantly elevated sub-G1 phase in AGS cells and G2/M phase cell cycle arrest in both AGS and MKN28 cells...
August 8, 2018: Nutrients
https://www.readbyqxmd.com/read/30088978/three-port-right-side-approach-duet-totally-laparoscopic-distal-gastrectomy-for-uncut-roux-en-y-reconstruction
#3
Ho Seok Seo, Yoon Ju Jung, Ji Hyun Kim, Cho Hyun Park, Han Hong Lee
BACKGROUND: This study presents the initial feasibility of three-port right-side approach-duet totally laparoscopic distal gastrectomy (R-duet TLDG) with uncut Roux-en-Y (R-Y) reconstruction for the treatment of lower- or middle-third gastric cancer. METHODS: A total of 30 patients who underwent R-duet TLDG with uncut R-Y reconstruction for gastric cancer were enrolled. All patients were treated at the Catholic Medical Center. Reconstructions were performed intracorporeally without special instruments...
August 8, 2018: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/30088107/successful-conversion-surgery-for-unresectable-gastric-cancer-with-giant-para-aortic-lymph-node-metastasis-after-downsizing-chemotherapy-with-s-1-and-oxaliplatin-a-case-report
#4
Akiko Serizawa, Kiyoaki Taniguchi, Takuji Yamada, Kunihiko Amano, Sho Kotake, Shunichi Ito, Masakazu Yamamoto
BACKGROUND: Although patients with stage IV gastric cancer who respond well to systemic chemotherapy can be treated with gastrectomy, the prognosis of patients with unresectable gastric cancer with para-aortic lymph node metastasis is poor. We herein report a case of remnant gastric cancer with para-aortic lymph node metastasis that was treated with potentially curative conversion surgery after showing a complete response to chemotherapy with S-1 and oxaliplatin (SOX). CASE PRESENTATION: An 81-year-old man was diagnosed with type 3 remnant gastric cancer with giant para-aortic lymph node metastasis, and he received SOX chemotherapy...
August 7, 2018: Surgical Case Reports
https://www.readbyqxmd.com/read/30080726/minimally-invasive-versus-open-distal-pancreatectomy-leopard-a-multicenter-patient-blinded-randomized-controlled-trial
#5
Thijs de Rooij, Jony van Hilst, Hjalmar van Santvoort, Djamila Boerma, Peter van den Boezem, Freek Daams, Ronald van Dam, Cees Dejong, Eino van Duyn, Marcel Dijkgraaf, Casper van Eijck, Sebastiaan Festen, Michael Gerhards, Bas Groot Koerkamp, Ignace de Hingh, Geert Kazemier, Joost Klaase, Ruben de Kleine, Cornelis van Laarhoven, Misha Luyer, Gijs Patijn, Pascal Steenvoorde, Mustafa Suker, Moh'd Abu Hilal, Olivier Busch, Marc Besselink
OBJECTIVE: This trial followed a structured nationwide training program in minimally invasive distal pancreatectomy (MIDP), according to the IDEAL framework for surgical innovation, and aimed to compare time to functional recovery after minimally invasive and open distal pancreatectomy (ODP). BACKGROUND: MIDP is increasingly used and may enhance postoperative recovery as compared with ODP, but randomized studies are lacking. METHODS: A multicenter patient-blinded randomized controlled superiority trial was performed in 14 centers between April 2015 and March 2017...
August 3, 2018: Annals of Surgery
https://www.readbyqxmd.com/read/30055545/modulatory-potential-of-curcumin-and-resveratrol-on-p53-post-translational-modifications-during-gastric-cancer
#6
Heng Xu, Wen-Bo Yu, Yuan Gao, Mei-Jun Zhang, Anshoo Malhotra, Wen-Hui Yu
The combination approach is now a well-established treatment for cancer. The present study evaluated the potential of curcumin and resveratrol on p53 post-translational modifications during gastric cancer. We segregated rats into five groups that included normal controls, dimethylhydrazine (DMH) treated, DMH + curcumin treated, DMH + resveratrol treated, and DMH + curcumin + resveratrol treated. Morphological analyses of tumor nodules confirmed carcinogenesis in rats after 25 weeks of DMH administration. The DMH treatment significantly induced carcinogenesis, as evidenced by high tumor burden in DMH-treated rats compared with controls...
2018: Journal of Environmental Pathology, Toxicology and Oncology
https://www.readbyqxmd.com/read/30021604/paired-box-8-suppresses-tumor-angiogenesis-and-metastasis-in-gastric-cancer-through-repression-of-foxm1-via-induction-of-microrna-612
#7
Liyan Wang, Xiaotong Bo, Qinghua Zheng, Wenhong Ge, Yanhua Liu, Bin Li
BACKGROUND: Paired box 8 (PAX8) has been documented to be downregulated in gastric cancer. However, its biological function in this malignancy is poorly understood. METHODS: In the present work, we investigated the effects of PAX8 overexpression and knockdown on the aggressive phenotype of gastric cancer cells. We further checked the involvement of forkhead box M1 (FOXM1), a ubiquitously expressed oncogene that can facilitate gastric cancer progression, in the action of PAX8...
July 18, 2018: Journal of Experimental & Clinical Cancer Research: CR
https://www.readbyqxmd.com/read/30015937/expression-of-transmembrane-protein-41a-is-associated-with-metastasis-via-the-modulation-of-e%C3%A2-cadherin-in-radically-resected-gastric-cancer
#8
Bin Lin, Yingming Xue, Chao Qi, Xiangjie Chen, Weizheng Mao
Gastric cancer (GC) is one of the most commonly occurring malignancies worldwide, and metastasis is one of the key processes affecting the prognosis of GC. TMEM41A, which belongs to a group of transmembrane proteins that participate in signaling pathways and tumor development, is a 264‑amino acid protein encoded by a gene mapped to human chromosome The exact role of TMEM41A in GC has not been determined to date. In the present study, the expression of TMEM41A in 147 cases of GC was analyzed with immunohistohemistry and the prognoses of these patients were analyzed...
September 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/30008904/conversion-therapy-for-advanced-gastric-cancer-with-trastuzumab-combined-with-chemotherapy-a-case-report
#9
Shuo-Meng Xiao, Rui Xu, Xiao-Li Tang, Zhi Ding, Ji-Man Li, Xiang Zhou
Gastric cancer is a common cancer of the gastrointestinal tract and the second most prevalent cause of cancer-associated mortality globally. Gastric cancer-associated mortality is increased in China compared with that in other countries. Key contributors to the poor prognosis of gastric cancer include late clinical presentation and genetic heterogeneity. Treatment based on the subtype of gastric cancer is important for effective therapy. The overexpression of the erb-b2 receptor tyrosine kinase 2 (ERBB2) gene and protein is associated with gastric cancer in humans...
August 2018: Oncology Letters
https://www.readbyqxmd.com/read/29986635/silencing-of-eno1-by-shrna-inhibits-the-proliferation-of-gastric-cancer-cells
#10
Hui Qiao, Yu-Feng Wang, Wen-Zhen Yuan, Bing-Dong Zhu, Lei Jiang, Quan-Lin Guan
α-Enolase is a significant subunit of enolase and acts as a glycolytic enzyme responsible for catalyzing the conversion of 2-phosphoglycerate to phosphoenolpyruvate in the anaerobic glycolysis pathway. The research about their role is known little in tumor invasion and metastasis. This research analyzed the effect of α-enolase in proliferation and progression of human gastric cancer. The constructed PLKO.1-ENO1 shRNA vector was transfected into 293 T cells and used to infect gastric cancer cells, MKN45, by using lentivirus method...
January 1, 2018: Technology in Cancer Research & Treatment
https://www.readbyqxmd.com/read/29963764/four-directional-approach-to-the-meso-transverse-attachment-combined-with-preoperative-radiological-vascular-simulation-facilitates-short-term-surgical-outcomes-in-laparoscopic-transverse-colon-cancer-surgery
#11
Koji Koinuma, Hisanaga Horie, Homare Ito, Daishi Naoi, Ai Sadatomo, Makiko Tahara, Yoshiyuki Inoue, Yoshihiko Kono, Takahiro Sasaki, Hideharu Sugimoto, Alan Kawarai Lefor, Naohiro Sata
INTRODUCTION: Transverse colon resection is one of the most difficult laparoscopic procedures because of anatomic hazards such as variations in the mesenteric vascular anatomy and the complex structure of organs and surrounding membranes. METHODS: We evaluated the short-term surgical outcomes of laparoscopic transverse colon resection using a creative approach. This approach included preoperative surgical simulation using virtual surgical anatomy by CT, a four-directional approach to the mesentery, and 3-D imaging during laparoscopic surgery...
July 2, 2018: Asian Journal of Endoscopic Surgery
https://www.readbyqxmd.com/read/29934732/resection-line-involvement-after-gastric-cancer-treatment-handle-with-care
#12
REVIEW
Paolo Morgagni, Giuliano La Barba, Eleonora Colciago, Giovanni Vittimberga, Giorgio Ercolani
The optimal management of patients with resection line involvement after endoscopic or surgical treatment for gastric cancer is debated. In contrast to previous reports, we examined both the experience of endoscopists and surgeons in early-stage lesions and the wide variation in treatments proposed for advanced disease in case of infiltration of resection margins. A PubMed search for papers using the key words: gastric or stomach cancer, or Carcinoma; gastrectomy and positive margins; surgical margins or resection line or endoscopic margin involvement; and R1 resection, from January 2000 to July 2015 was undertaken...
June 23, 2018: Updates in Surgery
https://www.readbyqxmd.com/read/29928144/expression-and-clinical-significance-of-autophagic-protein-lc3b-and-emt-markers-in-gastric-cancer
#13
Juan-Yi Wang, Tao Wu, Wu Ma, Shuo Li, Wen-Jiang Jing, Jun Ma, Dong-Mei Chen, Xiao-Jie Guo, Ke-Jun Nan
Background and aim: Gastric cancer (GC) is a fatal malignancy with high rate of recurrence and metastasis. Here, we investigated the correlations between the expression of autophagic protein LC3B and 2 epithelial-mesenchymal transition-related proteins (E-cadherin and Vimentin) and the clinicopathological factors and prognosis of patients with GC. Materials and methods: The expression of LC3B, E-cadherin, and Vimentin in GC samples (110 cases) and paracarcinoma tissues (40 cases) was analyzed using the Oncomine databases and further detected by immunohistochemistry...
2018: Cancer Management and Research
https://www.readbyqxmd.com/read/29920681/laparoscopic-proximal-gastrectomy-for-gastric-neoplasms
#14
Moshim Kukar, Emmanuel Gabriel, Kfir Ben-David, Steven N Hochwald
BACKGROUND: For cancers of the distal gastroesophageal junction or the proximal stomach, proximal gastrectomy can be performed. It is associated with several perioperative benefits compared with total gastrectomy. The use of laparoscopic proximal gastrectomy (LPG) has become an increasingly popular approach for select tumors. METHODS: We describe our method of LPG, including the preoperative work-up, illustrated depictions of the key steps of the surgery, and our postoperative pathway...
June 19, 2018: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29907681/case-studies-of-gastric-lung-and-oral-cancer-connect-etiologic-agent-prevalence-to-cancer-incidence
#15
Andrew F Brouwer, Marisa C Eisenberg, Rafael Meza
Obtaining detailed individual-level data on both exposure and cancer outcomes is challenging, and it is difficult to understand and characterize how temporal aspects of exposures translate into cancer risk. We show that, in lieu of individual-level information, population-level data on cancer incidence and etiologic agent prevalence can be leveraged to investigate cancer mechanisms and to better characterize and predict cancer trends. We use mechanistic carcinogenesis models [multistage clonal expansion (MSCE) models] and data on smoking, Helicobacter pylori ( H...
June 15, 2018: Cancer Research
https://www.readbyqxmd.com/read/29902454/ataxin-3-promotes-testicular-cancer-cell-proliferation-by-inhibiting-anti-oncogene-pten
#16
Zhan Shi, Jiaxin Chen, Xiangmin Zhang, Jian Chu, Zhitao Han, Da Xu, Sishun Gan, Xiuwu Pan, Jianqing Ye, Xingang Cui
Human Ataxin-3 protein was first identified as a transcript from patients with Machado-Joseph disease (MJD), also known as spinocerebellar ataxia type 3 (SCA3). Recent studies have demonstrated that Ataxin-3 is involved in gastric cancer and lung cancer. However, the role of Ataxin-3 in testicular cancer (TC) remains poorly understood. This study aims to explore the significance of Ataxin-3 expression in TC. Firstly, we investigated 53 paired TC and para-tumor tissues and found that Ataxin-3 was overexpressed in TC tissues, and this overexpression of Ataxin-3 was correlated with tumor stages...
September 3, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29872566/pd-l1-expression-is-a-prognostic-factor-in-subgroups-of-gastric-cancer-patients-stratified-according-to-their-levels-of-cd8-and-foxp3-immune-markers
#17
Le Ying, Feng Yan, Qiaohong Meng, Liang Yu, Xiangliang Yuan, Michael P Gantier, Bryan R G Williams, David W Chan, Liyun Shi, Yugang Tu, Peihua Ni, Xuefeng Wang, Weisan Chen, Xingxing Zang, Dakang Xu, Yiqun Hu
Current studies aiming at identifying single immune markers with prognostic value have limitations in the context of complex antitumor immunity and cancer immune evasion. Here, we show how the integration of several immune markers influences the predictions of prognosis of gastric cancer (GC) patients. We analyzed Tissue Microarray (TMA) by multiplex immunohistochemistry and measured the expression of immune checkpoint molecule PD-L1 together with antitumor CD8 T cells and immune suppressive FOXP3 Treg cells in a cohort of GC patients...
2018: Oncoimmunology
https://www.readbyqxmd.com/read/29866802/a-non-catalytic-antioxidant-role-for-helicobacter-pylori-urease
#18
Alan A Schmalstig, Stéphane L Benoit, Sandeep K Misra, Joshua S Sharp, Robert J Maier
The well-studied catalytic role of urease, the Ni-dependent conversion of urea into carbon dioxide and ammonia, has been shown to protect Helicobacter pylori against the low pH environment of the stomach lumen. We hypothesized that the abundantly expressed urease protein can play another, non-catalytic role in combating oxidative stress via Met-residue mediated quenching of harmful oxidants. Three catalytically inactive urease mutant strains were constructed by single substitutions of Ni binding residues. The mutant versions synthesize normal levels of urease and the altered versions retain all methionine residues...
June 4, 2018: Journal of Bacteriology
https://www.readbyqxmd.com/read/29849824/cell-free-circulating-methylated-sept9-for-noninvasive-diagnosis-and-monitoring-of-colorectal-cancer
#19
Bo Fu, Peng Yan, Shan Zhang, Yan Lu, Li Pan, Wenqiang Tang, Shen Chen, Shuangfeng Chen, Anqi Zhang, Wei Liu
Identification of early-stage tumor and monitoring therapeutic efficacy and recurrence or metastasis of colorectal cancer (CRC) are urgently warranted for improving the outcome of CRC patients and reducing the disease-related mortality. In this study, we evaluated the diagnostic value of cell-free circulating methylated SEPT9 (mSEPT9) for CRC and beyond CRC and examined the potentiality of mSEPT9 in assessing therapeutic efficacy and monitoring recurrence of CRC. Our results confirmed the favorable diagnostic value of plasma mSEPT9 for CRC, with a sensitivity of 61...
2018: Disease Markers
https://www.readbyqxmd.com/read/29844987/rapid-evolution-of-the-helicobacter-pylori-alpa-adhesin-in-a-high-gastric-cancer-risk-region-from-colombia
#20
Andrés Julián Gutiérrez-Escobar, Gina Méndez-Callejas, Orlando Acevedo, Maria Mercedes Bravo
To be able to survive, Helicobacter pylori must adhere to the gastric epithelial cells of its human host. For this purpose, the bacterium employs an array of adhesins, for example, AlpA. The adhesin AlpA has been proposed as a major adhesin because of its critical role in human stomach colonization. Therefore, understanding how AlpA evolved could be important for the development of new diagnostic strategies. However, the genetic variation and microevolutionary patterns of alpA have not been described in Colombia...
2018: PeerJ
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