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https://www.readbyqxmd.com/read/28544605/assessment-of-meibomian-glands-and-tear-film-in-post-refractive-surgery-patients
#1
Ji Won Jung, Jung Yong Kim, Hee Seung Chin, Young Ju Suh, Tae-Im Kim, Kyoung Yul Seo
IMPORTANCE: Corneal refractive surgery may impact meibomian gland and tear film in post-refractive surgery patients. BACKGROUND: To compare ocular surface parameters between post-refractive surgery patients and normal controls. DESIGN: Cross-sectional single center study PARTICIPANTS: A total of 120 eyes of 120 subjects were divided into three groups: (i) 60 controls and 60 patients underwent corneal refractive surgery at least 12 months ago; (ii) 30 post-laser in-situ keratomileusis (LASIK) patients and (iii) 30 post-laser epithelial keratomileusis (LASEK)/photo-refractive keratectomy (PRK) patients...
May 22, 2017: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/28542088/corneal-breakthrough-haze-after-photorefractive-keratectomy-with-mitomycin-c-incidence-and-risk-factors
#2
Igor Kaiserman, Naʼava Sadi, Michael Mimouni, Tzahi Sela, Gur Munzer, Shmuel Levartovsky
PURPOSE: To identify preoperative and intraoperative factors affecting breakthrough corneal haze incidence after photorefractive keratectomy (PRK) with mitomycin C (MMC). METHODS: In this retrospective study of PRK performed at the Care Vision Refractive Laser Center, Tel Aviv, Israel, a total of 7535 eyes (n = 3854 patients; mean age ± SD, 26 ± 6 years; 55% men) underwent PRK with intraoperative MMC application. Patients with histories of corneal pathology or surgery were excluded...
May 23, 2017: Cornea
https://www.readbyqxmd.com/read/28540005/post-photorefractive-keratectomy-pain-and-corneal-sub-basal-nerve-density
#3
Masoumeh Mohebbi, Amin Rafat-Nejad, Seyed-Farzad Mohammadi, Kosar Asna-Ashari, Maryam Kasiri, Saeed Heidari-Keshel, Farshad Askarizadeh
PURPOSE: The perceived and reported pain of patients receiving photorefractive keratectomy (PRK) widely varies. We assessed the potential role of the subbasal nerve plexus density as a predictor of postoperative pain level. Consecutive patients scheduled to undergo PRK at the Refractive Surgery Clinic of Farabi Eye Hospital, Tehran, were approached. METHODS: Forty-nine myopic left eyes from 49 patients who consented to undergo scanning slit confocal microscopy assessments preoperatively were included...
April 2017: Journal of Ophthalmic & Vision Research
https://www.readbyqxmd.com/read/28532931/infectious-keratitis-after-laser-vision-correction-incidence-and-risk-factors
#4
Julie M Schallhorn, Steven C Schallhorn, Keith Hettinger, Stephen Hannan
PURPOSE: To describe the incidence and risk factors associated with microbial keratitis in a large population of laser vision correction (LVC) patients. SETTING: Optical Express centers, Glasgow, United Kingdom. DESIGN: Retrospective case series. METHODS: Records were searched to identify all cases of presumed microbial keratitis after LVC between January 1, 2008, and April 1, 2015. Consecutive patients having primary or enhancement LVC during that time served as controls...
April 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28523525/etiology-and-outcomes-of-secondary-surgical-intervention-for-dissatisfied-patients-after-pseudophakic-monovision
#5
Sayaka Kato, Misae Ito, Kimiya Shimizu, Kazutaka Kamiya
PURPOSE: To evaluate the etiology and the clinical outcomes of secondary surgical interventions for dissatisfied patients after pseudophakic monovision. SETTING: Department of Ophthalmology, Kitasato University Hospital, Kanagawa, Japan. DESIGN: Retrospective case series. METHODS: This study comprised 12 eyes in 12 patients (age 66.2 ± 5.6 years) who underwent photorefractive keratectomy (PRK) enhancement to improve their dissatisfaction after pseudophakic monovision...
May 18, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28522266/site-specific-conjugation-of-fibroblast-growth-factor-2-fgf2-based-on-incorporation-of-alkyne-reactive-unnatural-amino-acid
#6
K W Swiderska, A Szlachcic, A Czyrek, M Zakrzewska, J Otlewski
Recent advances in site-specific protein modification include the increasingly popular incorporation of unnatural amino acid(s) using amber codon, a method developed by Schultz and coworkers. In this study, we employ this technique to introduce propargyllysine (PrK) in human fibroblast growth factor 2 (FGF2). Owing to an alkyne moiety in its side chain, PrK is compatible with Cu(I)-catalyzed azide-alkyne 1,3-dipolar cycloaddition (CuAAC). We successfully tested CuAAC-mediated conjugation of FGF2 with two compounds - a fluorophore carboxyrhodamine 110 or a cytotoxic drug monomethyl auristatin E (MMAE)...
May 5, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28513498/combination-of-phototherapeutic-keratectomy-and-wavefront-guided-photorefractive-keratectomy-for-the-treatment-of-thiel-behnke-corneal-dystrophy
#7
Chia-Chieh Hsiao, Yu-Chih Hou
Phototherapeutic keratectomy (PTK) has been used to treat anterior corneal dystrophy but may cause hyperopic shift or corneal high-order aberration. We describe the successful treatment of a case of a 43-year-old female with Thiel-Behnke corneal dystrophy, using PTK followed by wavefront-guided photorefractive keratectomy (PRK). The patient had high corneal aberration and hyperopic shift after PTK in both eyes. The corneal surface regularity index and surface asymmetric index increased after PTK and decreased after wavefront-guided PRK...
April 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28486725/regeneration-of-defective-epithelial-basement-membrane-and-restoration-of-corneal-transparency-after-photorefractive-keratectomy
#8
Gustavo K Marino, Marcony R Santhiago, Abirami Santhanam, Andre A M Torricelli, Steven E Wilson
PURPOSE: To study regeneration of the normal ultrastructure of the epithelial basement membrane (EBM) in rabbit corneas that had -9.00 D photorefractive keratectomy (PRK) and developed late haze (fibrosis) with restoration of transparency over 1 to 4 months after surgery and in corneas that had incisional wounds. METHODS: Twenty-four rabbits had one of their eyes included in one of the two procedure groups (-9.00 D PRK or nearly full-thickness incisional wounds), whereas the opposite eyes served as the unwounded control group...
May 1, 2017: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/28430985/arabidopsis-cp12-mutants-have-reduced-levels-of-phosphoribulokinase-and-impaired-function-of-the-calvin-benson-cycle
#9
Patricia Elena López-Calcagno, Amani Omar Abuzaid, Tracy Lawson, Christine Anne Raines
CP12 is a small, redox-sensitive protein, the most detailed understanding of which is the thioredoxin-mediated regulation of the Calvin-Benson cycle, where it facilitates the formation of a complex between glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and phosphoribulokinase (PRK) in response to changes in light intensity. In most organisms, CP12 proteins are encoded by small multigene families, where the importance of each individual CP12 gene in vivo has not yet been reported. We used Arabidopsis thaliana T-DNA mutants and RNAi transgenic lines with reduced levels of CP12 transcript to determine the relative importance of each of the CP12 genes...
April 20, 2017: Journal of Experimental Botany
https://www.readbyqxmd.com/read/28410723/risk-factors-predicting-steroid-induced-ocular-hypertension-after-photorefractive-keratectomy
#10
Yumna Busool, Michael Mimouni, Igor Vainer, Shmuel Levartovsky, Tzahi Sela, Gur Munzer, Igor Kaiserman
PURPOSE: To assess the risk factors contributing to steroid-induced ocular hypertension after photorefractive keratectomy (PRK). SETTING: Care Laser Centers, Tel Aviv, Israel. DESIGN: Retrospective case series. METHODS: Patients having PRK between January 2000 and December 2015 were followed for at least 3 months. Intraocular pressure (IOP) was measured using the Goldmann applanation tonometer after 1 week and after 1, 3, and 6 months...
March 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28410722/visual-outcomes-of-laser-vision-correction-in-eyes-with-preoperative-amblyopia
#11
Nir Sorkin, David Varssano, David Smadja, Ainat Klein, Michael Mimouni, Amir Rosenblatt
PURPOSE: To evaluate the visual outcomes of photorefractive keratectomy (PRK) and laser in situ keratomileusis (LASIK) in amblyopic eyes. SETTING: Care Vision Refractive Clinic, Tel Aviv, Israel. DESIGN: Retrospective case series. METHODS: Amblyopic eyes of patients with a preoperative corrected distance visual acuity (CDVA) of 20/33 or worse had PRK or LASIK. Postoperative visual outcomes (uncorrected distance visual acuity, CDVA) and correlations with age, preoperative CDVA, refractive error type, astigmatism grade, procedure type, laser suite model, amblyopia grade, and amblyopia type were analyzed...
March 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28392938/effect-of-mitomycin-c-on-myopic-versus-astigmatic-photorefractive-keratectomy
#12
Ashwag A Almosa, Samah M Fawzy
Purpose. Long-term mitomycin C (MMC) effects on photorefractive keratectomy (PRK) were compared in simple myopic and astigmatic patients. Methods. In this observational cohort study, subjects were selected based on preoperative and postoperative data collected from medical records; they were divided into simple myopia with/without MMC and myopic astigmatism with/without MMC groups. Haze, uncorrected visual acuity (UCVA), best-corrected visual acuity (BCVA), subjective refraction, and K-reading were evaluated at 1-, 3-, 6-, and 12-month follow-ups...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28377594/tgfbi-gene-mutation-analysis-of-clinically-diagnosed-granular-corneal-dystrophy-patients-prior-to-ptk-a-pilot-study-from-eastern-china
#13
Li Zeng, Jing Zhao, Yingjun Chen, Feng Zhao, Meiyan Li, Connie Chao-Shern, Tara Moore, John Marshall, Xingtao Zhou
This study investigated the TGFBI gene mutation types in outpatients clinically diagnosed with granular corneal dystrophy (GCD) prior to phototherapeutic keratectomy (PTK), also calculated the mutation rate of subjects with normal corneas, but positive family history. Clinical GCD outpatients and consanguineous family members were enrolled in this study. Among total 42 subjects: 24 patients from 23 unrelated families had typical signs of GCD on corneas; 5 patients from 5 unrelated families had atypical signs; 13 subjects from 11 unrelated families had no corneal signs but positive family history...
April 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28367530/choroidal-neovascularization-following-photorefractive-keratectomy
#14
Hamidreza Torabi, Seyed-Hashem Daryabari
PURPOSE: To describe a case of choroidal neovascularization (CNV) following photorefractive keratectomy (PRK) to correct myopia. METHODS: We performed PRK in both eyes of a 20-year-old girl to correct myopia. Refractive error was -4.75 -2.25 × 5 in the right eye and -5.00 -1.25 × 180 in the left eye. Metamorphopsia was noticed by the patient in the right eye one month after the surgical procedure. The patient was referred 3 months later when visual loss happened...
March 2017: Journal of Current Ophthalmology
https://www.readbyqxmd.com/read/28366365/intraocular-lens-power-calculations-in-eyes-with-previous-hyperopic-laser-in-situ-keratomileusis-or-photorefractive-keratectomy
#15
Eric B Hamill, Li Wang, Hayley K Chopra, Warren Hill, Douglas D Koch
PURPOSE: To evaluate the accuracy of 7 intraocular lens (IOL) calculation formulas in patients with previous hyperopic laser in situ keratomileusis (LASIK) or excimer laser photorefractive keratectomy (PRK). DESIGN: Retrospective case series. SETTING: Cullen Eye Institute, Baylor College of Medicine, Houston, Texas, and private practice, Mesa, Arizona, USA. METHODS: The 7 formulas evaluated were the adjusted Atlas 0-3, Masket, Modified Masket, Haigis-L, Shammas-PL, Barrett True-K, and Barrett True-K No-History...
February 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28366363/comparison-of-clinical-outcomes-between-wavefront-optimized-versus-corneal-wavefront-guided-transepithelial-photorefractive-keratectomy-for-myopic-astigmatism
#16
Ikhyun Jun, David Sung Yong Kang, Jerry Tan, Jin Young Choi, Woon Heo, Joo Young Kim, Min Goo Lee, Eung Kweon Kim, Kyoung Yul Seo, Tae-Im Kim
PURPOSE: To evaluate and compare the clinical outcomes, including visual acuity, refractive errors, and aberrations, between aberration-free transepithelial photorefractive keratectomy (PRK) and corneal wavefront-guided transepithelial PRK in eyes with myopic astigmatism. SETTING: Yonsei University College of Medicine and Eyereum Eye Clinic, Seoul, South Korea. DESIGN: Retrospective comparative case series. METHODS: Patients with myopic astigmatism were treated with aberration-free transepithelial PRK or corneal wavefront-guided transepithelial PRK using a 1050 Hz high-repetition excimer laser...
February 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28366362/femtosecond-laser-assisted-laser-in-situ-keratomileusis-versus-photorefractive-keratectomy-effect-on-ocular-surface-condition
#17
Paola Sauvageot, Gemma Julio, Juan Alvarez de Toledo, Victor Charoenrook, Rafael I Barraquer
PURPOSE: To compare ocular surface characteristics in eyes after femtosecond laser-assisted laser in situ keratomileusis (LASIK) or photorefractive keratectomy (PRK). SETTING: Centro de Oftalmologia Barraquer, Barcelona, Spain. DESIGN: Prospective comparative observational study. METHODS: Patients with myopia who had femtosecond laser-assisted LASIK or PRK were included. Tear osmolarity, the Ocular Surface Disease Index questionnaire, Schirmer I, corneal sensitivity, tear breakup time (TBUT), and corneal fluorescein staining were evaluated preoperatively and 3, 6, and 12 months postoperatively...
February 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28362808/comparison-of-laser-in-situ-ketatomileusis-and-photorefractive-keratectomy-for-myopia-using-a-mixed-effects-model
#18
Yosai Mori, Kazunori Miyata, Takashi Ono, Yusuke Yagi, Kazutaka Kamiya, Shiro Amano
PURPOSE: To compare the results of laser in situ keratomileusis (LASIK) and photorefractive keratectomy (PRK) for myopia using a mixed-effects model. METHODS: This comparative retrospective study was conducted in 1,127 eyes of 579 patients after LASIK and 270 eyes of 144 patients after PRK who had two or more postoperative follow-ups after 3 months. Uncorrected visual acuity (UCVA), best spectacle-corrected visual acuity (BSCVA), manifest refractive spherical equivalent (MRSE), percentage of eyes within ± 0...
2017: PloS One
https://www.readbyqxmd.com/read/28356712/a-protocol-for-topographic-guided-corneal-repair-utilizing-the-us-food-and-drug-administration-approved-wavelight-contoura
#19
Manoj Motwani
PURPOSE: To demonstrate how Wavelight Contoura can be used to repair corneas damaged by trauma and prior poor surgical outcomes. METHODS: Four representative eyes are presented that show different scenarios in which highly irregular corneas can be corrected with Wavelight Contoura using a protocol (named the San Diego Protocol) designed to use the information in Contoura processing. Both laser-assisted in situ keratomileusis (LASIK) and photorefractive keratectomy (PRK) were used...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28349503/comparison-of-visual-and-refractive-results-after-transepithelial-and-mechanical-photorefractive-keratectomy-in-myopia
#20
Yusuf Yildirim, Onur Olcucu, Nese Alagoz, Alper Agca, Yalcin Karakucuk, Ahmet Demirok
PURPOSE: To compare postoperative visual outcomes and higher-order aberrations (HOAs) following transepithelial photorefractive keratectomy (t-PRK) and mechanical photorefractive keratectomy (m-PRK). METHODS: The medical records of patients who underwent photorefractive keratectomy (PRK) were retrospectively evaluated. Forty-five patients were treated with m-PRK, and 45 were treated with t-PRK. Visual acuity, subjective manifest refraction, and corneal topography were analyzed before surgery and 12 months after surgery for both groups...
March 27, 2017: International Ophthalmology
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