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https://www.readbyqxmd.com/read/28339457/targeted-aav5-smad7-gene-therapy-inhibits-corneal-scarring-in-vivo
#1
Suneel Gupta, Jason T Rodier, Ajay Sharma, Elizabeth A Giuliano, Prashant R Sinha, Nathan P Hesemann, Arkasubhra Ghosh, Rajiv R Mohan
Corneal scarring is due to aberrant activity of the transforming growth factor β (TGFβ) signaling pathway following traumatic, mechanical, infectious, or surgical injury. Altered TGFβ signaling cascade leads to downstream Smad (Suppressor of mothers against decapentaplegic) protein-mediated signaling events that regulate expression of extracellular matrix and myogenic proteins. These events lead to transdifferentiation of keratocytes into myofibroblasts through fibroblasts and often results in permanent corneal scarring...
2017: PloS One
https://www.readbyqxmd.com/read/28337058/comparison-of-microkeratome-assisted-sub-bowman-keratomileusis-with-photorefractive-keratectomy
#2
Talal A Althomali
PURPOSE: To compare the outcomes of photorefractive keratectomy (PRK) and thin-flap Laser-Assisted in Situ Keratomileusis/sub-Bowman keratomileusis (SBK) with intended flap thicknesses of 100 μm using the One Use-Plus SBK microkeratome. METHODS: Ninety-eight eyes of 52 subjects with myopic manifest refraction spherical equivalent (MRSE) of up to -5 diopters (D), a stable refraction for 1 year and a corrected distance visual acuity (CDVA) of at least 20/20 in each eye which had undergone SBK or PRK were reviewed retrospectively...
January 2017: Saudi Journal of Ophthalmology: Official Journal of the Saudi Ophthalmological Society
https://www.readbyqxmd.com/read/28336402/post-operative-efficacy-predictability-safety-and-visual-quality-of-laser-corneal-refractive-surgery-a-network-meta-analysis
#3
Daizong Wen, Colm McAlinden, Ian Flitcroft, Ruixue Tu, Qinmei Wang, Jorge Alió, John Marshall, Yingying Huang, Benhao Song, Liang Hu, Yune Zhao, Senmiao Zhu, Rongrong Gao, Fangjun Bao, Ayong Yu, Ye Yu, Hengli Lian, Jinhai Huang
PURPOSE: To compare the post-operative efficacy, predictability, safety and visual quality of all major forms of laser corneal refractive surgeries for correcting myopia. DESIGN: Systematic review and network meta-analysis. METHODS: MEDLINE, EMBASE, Cochrane Library and the US trial registry was conducted up to November 2015. Randomized controlled trials (RCT) reporting in accordance with the eligibility criteria were included in this review...
March 20, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28318639/enhancement-after-small-incision-lenticule-extraction-incidence-risk-factors-and-outcomes
#4
Yu-Chi Liu, Mohamad Rosman, Jodhbir S Mehta
PURPOSE: To report the incidence, risk factors, and outcomes of enhancement after small-incision lenticule extraction (SMILE). DESIGN: Retrospective cohort study. PARTICIPANTS: Five hundred twenty-four eyes of 307 patients who underwent SMILE at Singapore National Eye Center between February 2012 and March 2016. METHODS: The data collected included patient age at primary SMILE, gender, race, preoperative and postoperative manifest refraction spherical equivalent (MRSE), preoperative and postoperative uncorrected distance visual acuity and corrected distance visual acuity, the occurrence of suction loss during the procedure, and the need for enhancement...
March 15, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28317678/quality-of-vision-after-wavefront-guided-laser-in-situ-keratomileusis-or-photorefractive-keratectomy-contralateral-eye-evaluation
#5
Michele D Lee, Edward E Manche
PURPOSE: To compare quality of vision between laser in situ keratomileusis (LASIK) and photorefractive keratectomy (PRK). SETTING: Byers Eye Institute, Stanford University School of Medicine, Palo Alto, California, USA. DESIGN: Prospective randomized case series. METHODS: Patients had refractive surgery, with 1 eye treated with LASIK and the other with PRK. Eyes were randomized for dominance. The patients completed a questionnaire assessing quality of vision in each eye at the initial visit and 1, 3, 6, and 12 months postoperatively...
January 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28299001/comparison-of-loteprednol-with-fluorometholone-after-myopic-photorefractive-keratectomy
#6
Farid Karimian, Amir Faramarzi, Sahba Fekri, Hossein Mohammad-Rabie, Danial Najdi, Azadeh Doozandeh, Siamak Delfaza-Baher, Mehdi Yaseri
PURPOSE: To compare the efficacy and side effects of loteprednol versus fluorometholone after myopic photorefractive keratectomy (PRK). METHODS: One hundred and twenty four eyes of 62 patients who underwent PRK were enrolled in this study. One eye of each subject was randomized to receive loteprednol 0.5% and the fellow eye was given fluorometholone 0.1%. Patients were followed up for three months. RESULTS: There was no significant difference in uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), manifest refraction, corneal haze, intraocular pressure (IOP), and ocular discomfort and redness between groups at the final visit...
January 2017: Journal of Ophthalmic & Vision Research
https://www.readbyqxmd.com/read/28275314/ebm-regeneration-and-changes-in-ebm-component-mrna-expression-in-stromal-cells-after-corneal-injury
#7
Abirami Santhanam, Gustavo K Marino, Andre A M Torricelli, Steven E Wilson
PURPOSE: To investigate the production of the epithelial basement membrane (EBM) component mRNAs at time points before lamina lucida and lamina densa regeneration in anterior stromal cells after corneal injury that would heal with and without fibrosis. METHODS: Rabbit corneas were removed from 2 to 19 days after -4.5D or -9.0D photorefractive keratectomy (PRK) with the VISX S4 IR laser. Corneas were evaluated with transmission electron microscopy (TEM) for full regeneration of the lamina lucida and the lamina densa...
2017: Molecular Vision
https://www.readbyqxmd.com/read/28270007/-impact-of-crosslinking-on-corneal-epithelial-healing
#8
Andrea Gyenes, Nóra Szentmáry, Gábor Tóth, Huba Kiss, Csaba Szekrényesi, Achim Langenbucher, Zoltán Zsolt Nagy
INTRODUCTION AND AIM: To analyse the effect of crosslinking (CXL) on corneal epithelial healing. PATIENTS AND METHOD: 39 keratoconus patients following CXL and 11 patients following PRK were enrolled in this study. 21, 45 and 69 hours after CXL and 16, 37 and 61 hours following PRK slitlamp photographs were taken using fluorescein staining and the size of the epithelial defect and the time of epithelial closure was determined. As the observation time-points differed in both groups, the size of the epithelial defect following PRK was calculated for the time points used for analysis of CXL patients...
March 2017: Orvosi Hetilap
https://www.readbyqxmd.com/read/28264136/phototherapeutic-keratectomy-science-and-art
#9
Steven E Wilson, Gustavo K Marino, Carla S Medeiros, Marcony R Santhiago
PURPOSE: To describe, with videos, the principles of excimer laser phototherapeutic keratectomy (PTK) for the treatment of corneal scars, corneal surface irregularity, and recurrent corneal erosions. METHODS: Depending on the pathology in a treated cornea, the epithelium is removed either by transepithelial PTK ablation with the excimer laser or thorough scraping with a scalpel blade. Stromal PTK can be performed with or without photorefractive keratectomy (PRK), depending on the refractive status of both eyes...
March 1, 2017: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/28264134/biomechanical-weakening-of-different-re-treatment-options-after-small-incision-lenticule-extraction-smile
#10
Sabine Kling, Bogdan Spiru, Farhad Hafezi, Walter Sekundo
PURPOSE: To determine the corneal weakening induced by different re-treatment options after small incision lenticule extraction (SMILE) and investigate the potential of corneal cross-linking (CXL) to reestablish the original corneal stress resistance. METHODS: A total of 96 freshly enucleated porcine corneas were used. The initial refractive correction was defined to be -11.00 diopters (D) and the required enhancement to be -3.00 D. Three different re-treatment options were analyzed: -3D Re-SMILE, -3D photorefractive keratectomy (PRK) on top of the SMILE cap, and cap-to-flap conversion and -3D excimer ablation on the stromal bed (LASIK)...
March 1, 2017: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/28256362/effect-of-pulsed-laser-light-in-patients-with-dry-eye-syndrome
#11
S Guilloto Caballero, J L García Madrona, E Colmenero Reina
OBJECTIVES: The objective of this study was to determine the clinical benefits of pulsed light therapy for the treatment of Dry Eye Syndrome (DES) due to the decrease in aqueous tear production (aqueous deficient DES) and/or excessive tear evaporation (evaporative DES) due to Meibomian Gland Dysfunction (MGD). METHODS: A study was conducted on 72 eyes corresponding to 36 patients with DES. Out of these 72 eyes, 60 underwent refractive surgery (48 with femtosecond laser, 6 were operated with a mechanical microkeratome, and 6 with refractive photo-keratectomy[RPK], 6 treated with phacoemulsification, and 6 with no previous surgical treatment...
February 28, 2017: Archivos de la Sociedad Española de Oftalmología
https://www.readbyqxmd.com/read/28243023/validity-of-tono-pachymetry-for-measuring-corrected-intraocular-pressure-in-non-surgical-and-post-photorefractive-keratectomy-eyes
#12
In Kyun Hahn, Jae Yong Kim, Myoung Joon Kim, Hungwon Tchah, Chan Hee Moon
PURPOSE: To assess the validity of central corneal thickness (CCT) and corrected intraocular pressure (IOP) values obtained by tono-pachymetry in non-surgical and post-photorefractive keratectomy (PRK) eyes. METHODS: For the study, 108 young healthy participants and 108 patients who had PRK were enrolled. Measurements were randomly performed by tono-pachymetry, ultrasonic (US) pachymetry, and Goldmann applanation tonometry (GAT). CCT measurement by tono-pachymetry was compared to that of US pachymetry...
February 2017: Korean Journal of Ophthalmology: KJO
https://www.readbyqxmd.com/read/28197998/laser-assisted-subepithelial-keratectomy-lasek-versus-laser-assisted-in-situ-keratomileusis-lasik-for-correcting-myopia
#13
REVIEW
Jocelyn Kuryan, Anjum Cheema, Roy S Chuck
BACKGROUND: Near-sightedness, or myopia, is a condition in which light rays entering the eye along the visual axis focus in front of the retina, resulting in blurred vision. Myopia can be treated with spectacles, contact lenses, or refractive surgery. Options for refractive surgery include laser-assisted subepithelial keratectomy (LASEK) and laser-assisted in-situ keratomileusis (LASIK). Both procedures utilize a laser to shape the corneal tissue (front of the eye) to correct refractive error, and both create flaps before laser treatment of corneal stromal tissue...
February 15, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28192838/topography-guided-prk-and-crosslinking-in-eyes-with-keratoconus-and-post-lasik-ectasia
#14
T M Müller, A P Lange
Topography-guided photorefractive keratectomy (TG-PRK) combined with corneal collagen crosslinking (CXL) has been shown to potentially improve vision and stabilize progression in patients with keratoconus (KC). We attempted to reproduce the previously published results using a different laser platform (AMARIS 500E) in patients with KC and post-LASIK ectasia (PLE). All of the 9 included eyes showed improved topography (Kmax, Kmean, RMS HOA, vertical coma, cylinder; p < 0.05) and improved visual acuity (BCVA, UCVA; p < 0...
February 13, 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28192591/lasik-enhancement-clinical-and-surgical-management
#15
Majid Moshirfar, Naz Jehangir, Carlton R Fenzl, Michael McCaughey
PURPOSE: To review refractive regression and current therapeutic options for patients who have residual refractive error after LASIK. METHODS: An extensive literature search using PubMed was performed for terms such as "LASIK," "PRK," "enhancement," "overcorrection," "undercorrection," "re-lift," "mini-flap," and related terms. RESULTS: The presence of residual refractive error following LASIK is a challenging situation. After excluding anatomical causes (eg, ocular surface disease, cataract, and macular pathology) and intraoperative flap complications, evaluation of the residual stromal bed must be performed...
February 1, 2017: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/28192202/ethnomedicinal-uses-of-plants-for-the-treatment-of-malaria-in-soon-valley-khushab-pakistan
#16
Amin Shah, Sarvat Rahim
ETHNOPHARMACOLOGICAL RELEVANCE: To best of our knowledge this is the first quantitative ethno-medicinal study with the aim of documenting the indigenous knowledge and practices of using plants for malarial therapy in Soon Valley, Khushab, Pakistan. In this Valley, malaria is among the major public health problems but, until now, the population still mostly relies on herbal medicine for treatment. MATERIALS AND METHODS: Ethno-medicinal data were documented from 63 informants by using semi-structured questionnaires and interviewing the informants about their knowledge of plants regarding malaria and related symptoms...
March 22, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28188942/photorefractive-keratectomy-with-mitomycin-c-for-high-myopia-three-year-follow-up-results
#17
Hassan Hashemi, Yahya Salimi, Poopak Pir, Soheila Asgari
Photorefractive keratectomy (PRK) is a safe and effective surgical keratorefractive technique which is done with the application of mitomycin-C (MMC) in cases of high myopia to prevent the formation of corneal haze This study was conducted to evaluate 3-year visual acuity and quality outcomes of PRK-MMC in high myopia. This before-after study was conducted on 20 individuals (40 eyes) with myopia more than 6.0 diopter (D). Visual acuity and quality indices were evaluated before and three years after the procedure and their stability was examined between the 1st and 3rd years...
January 2017: Acta Medica Iranica
https://www.readbyqxmd.com/read/28187472/-epi-bowman-keratectomy-clinical-evaluation-of-a-new-method-of-surface-ablation
#18
S Taneri, S Kießler, A Rost, T Schultz, M Elling, B Dick
Purpose A new device for epithelial abrasion before excimer laser surface ablation or corneal cross-linking (CXL) has recently been introduced (Epi-Clear™, Orca Surgical, Kiryat-Shmona, Israel). We have reviewed the literature on the clinical results, potential benefits and drawbacks of this instrument, compared to other methods of epithelial removal. Method Literature search for "Epi-Bowman Keratectomy", "Epi-clear", and "Epikeratome" yielded 1 peer-review publication, 1 non-peer-review publication, 18 posters and presentations at international conferences (European Society of Cataract and Refractive Surgeons [ESCRS] and American Society of Cataract and Refractive Surgery [ASCRS]) on the use of the Epi-Clear™ device before surface ablation, 2 posters on the use of Epi-Clear before corneal crosslinking and 1 presentation on the experimental use of Epi-Clear for removal of a pterygium...
February 10, 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28168049/photorefractive-keratectomy-for-residual-myopia-after-myopic-laser-in-situ-keratomileusis
#19
Kamal A M Solaiman, Sameh M Fouda, Ashraf Bor'i, Haitham Y Al-Nashar
Purpose. To evaluate the safety, efficacy, and predictability of photorefractive keratectomy (PRK) on the corneal flap for correction of residual myopia following myopic laser in situ keratomileusis (LASIK). Patients and Methods. A retrospective study on eyes retreated by PRK on the corneal flap for residual myopia after LASIK. All eyes had no enough stroma after LASIK sufficient for LASIK enhancement. Data included spherical equivalent (SE), uncorrected and best corrected visual acuity (UCVA and BCVA), central pachymetry, corneal higher order aberrations (HOAs), corneal hysteresis (CH), corneal resistance factor (CRF), and corneal haze...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28135746/-smile-re-treatment-options-techniques-and-results
#20
B Meyer, K S Kunert
With a rate of less than 2 %, retreatment after SMILE is rare. If a touch-up is required, there are different options to choose from: surface ablation (PRK/LASEK) with Mitomycin C, the standard femto-flap procedure with the same parameters, the CIRCLE procedure, which extends the previous SMILE interface into a flap, or the innovative but off-label capless SMILE procedure, which preserves all the advantages of SMILE.
January 2017: Klinische Monatsblätter Für Augenheilkunde
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