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Hassan Hashemi, Reza Ghaffari, Mohammad Miraftab, Soheila Asgari
PURPOSE: To compare 18-month outcomes between femtosecond laser-assisted LASIK (femto-LASIK) and photorefractive keratectomy with mitomycin-C (PRK-MMC) for myopia of more than 7.0 D in terms of visual acuity and quality. METHODS: In this comparative nonrandomized clinical trial, 60 eyes from 30 patients (30 eyes in each group) were enrolled. The two procedures were compared in terms of 18-month changes in uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), manifest refraction spherical equivalent, ocular and corneal higher order aberrations (HOAs), and contrast sensitivity (CS)...
October 3, 2016: International Ophthalmology
Jie Hou, Yan Wang, Yulin Lei, Xiuyun Zheng, Ying Zhang
Purpose. To evaluate the changes in epithelial thickness profile following transepithelial photorefractive keratectomy (T-PRK) for myopia and to investigate the effect of epithelial remodeling on corneal asphericity. Methods. Forty-four patients (44 right eyes) who underwent T-PRK were retrospectively evaluated. Epithelial thickness was measured using spectral-domain optical coherence tomography at different corneal zones (central, 2 mm; paracentral, 2-5 mm; and mid-peripheral, 5-6 mm) preoperatively and at 1 week and 1, 3, and 6 months postoperatively...
2016: Journal of Ophthalmology
William Joseph Dupps, Ibrahim Seven
PURPOSE: To investigate biomechanical strain as a structural susceptibility metric for corneal ectasia in a large-scale computational trial. METHODS: A finite element modeling study was performed using retrospective Scheimpflug tomography data from 40 eyes of 40 patients. LASIK and PRK were simulated with varied myopic ablation profiles and flap thickness parameters across eyes from LASIK candidates, patients disqualified for LASIK, subjects with atypical topography, and keratoconus subjects in 280 simulations...
August 2016: Transactions of the American Ophthalmological Society
Tommy C Y Chan, Marco C Y Yu, Alex Ng, Zheng Wang, George P M Cheng, Vishal Jhanji
We prospectively compared visual and refractive outcomes in patients with high myopia and myopic astigmatism after small-incision lenticule extraction (SMILE) and photorefractive keratetctomy (PRK) with mitomycin C. Sixty-six eyes of 33 patients (mean age, 29.7 ± 5.6 years) were included (SMILE: 34 eyes, PRK 32 eyes). Preoperatively, no significant difference was noted in manifest spherical equivalent (p = 0.326), manifest sphere (p = 0.277), and manifest cylinder (p = 0.625) between both groups...
2016: Scientific Reports
Xiangjun Chen, Aleksandar Stojanovic, Xiaorui Wang, Jing Liang, Di Hu, Tor Paaske Utheim
PURPOSE: To evaluate corneal epithelial remodeling after topography-guided transepithelial photorefractive keratectomy (PRK) combined with corneal collagen cross-linking (CXL) in the treatment of keratoconus. METHODS: Retrospective analysis of the epithelial thickness distribution changes in 53 keratoconic eyes of 44 patients. Manifest refraction, maximum (Kmax) and minimum (Kmin) keratometry obtained by Placido topography, corneal irregularity index (IRI) measured by Scheimpflug topography, and the epithelial thickness profile over the central 5-mm zone obtained by anterior-segment spectral domain optical coherence tomography (SD-OCT) were evaluated preoperatively and at 1 to 3, 3 to 6, and more than 6 months postoperatively...
August 1, 2016: Journal of Refractive Surgery
Yusuf Yildirim, Onur Olcucu, Cengiz Alagoz, Abdurrahman Basci, Alper Agca, Dilek Yasa, Engin Bilge Ozgurhan, Ahmet Demirok
PURPOSE: To compare the refractive outcomes of small incision lenticule extraction (SMILE) with photorefractive keratectomy (PRK) using an aberration-free ablation profile. METHODS: One eye of patients diagnosed as having myopia for bilateral refractive correction was randomly allocated to either PRK or SMILE. The primary outcome measures included refractive efficacy, predictability, safety, stability, corneal aberrations, and adverse events. Patients were followed up for 1 year postoperatively; postoperative uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), manifest refraction, and corneal aberrations were recorded and compared with preoperative data...
August 1, 2016: Journal of Refractive Surgery
Shumoos Al-Fahdawi, Rami Qahwaji, Alaa S Al-Waisy, Stanley Ipson, Rayaz A Malik, Arun Brahma, Xin Chen
Diabetic Peripheral Neuropathy (DPN) is one of the most common types of diabetes that can affect the cornea. An accurate analysis of the nerve structures can assist the early diagnosis of this disease. This paper proposes a robust, fast and fully automatic nerve segmentation and morphometric parameter quantification system for corneal confocal microscope images. The segmentation part consists of three main steps. First, a preprocessing step is applied to enhance the visibility of the nerves and remove noise using anisotropic diffusion filtering, specifically a Coherence filter followed by Gaussian filtering...
October 2016: Computer Methods and Programs in Biomedicine
Suphi Taneri, Saskia Oehler, Scott MacRae, H Burkhard Dick
OBJECTIVES: To examine the influence of a therapeutic soft contact lens (TSCL) after alcohol-assisted photorefractive keratectomy (PRK) on visual recovery, epithelial closure, pain perception, and haze formation. METHODS: Prospective, randomized, single-center, contralateral eye, patient-masked study. Same surgeon treated 15 patients with bilateral PRK using a Vidaurri Fluid Retention Ring (Katena) with 8.7 mm inner diameter to apply ethanol 18% for 30 sec. Each patient received a TSCL (Balafilcon A, PureVision, Bausch & Lomb) in a randomized fashion in one eye only...
August 30, 2016: Eye & Contact Lens
Francisco Irochima Pinheiro, Irami Araújo-Filho, Amalia Cinthia Meneses do Rego, Eduardo Pereira de Azevedo, Eryvaldo Socrates Tabosa do Egito, Fernando Oréfice, Acácio Alves de Souza Lima Filho
PURPOSE: To develop a new corneal release system to deliver optimum amounts of mitomycin-C (MMC) during the perioperative period of photorefractive keratectomy (PRK). SETTING: Ophthalmos S/A, São Paulo, Brazil. DESIGN: Experimental study. METHODS: An in vitro experimental design was developed for studying a new MMC delivery system at a drug concentration of 0.02%. Whatman sterile filter paper disks with a diameter of 8...
August 2016: Journal of Cataract and Refractive Surgery
Imene Salah-Mabed, Alain Saad, Damien Gatinel
PURPOSE: To compare the epithelium (air-tear film) and Bowman layer's specular topographies in patients having low to moderate myopia corrected by photorefractive keratectomy (PRK). SETTING: Rothschild Foundation, Paris, France. DESIGN: Prospective interventional case series. METHODS: Anterior corneal specular Placido topography using the OPD-Scan II Placido-based topographer was performed in eyes of patients having PRK for myopia before and after epithelial removal...
August 2016: Journal of Cataract and Refractive Surgery
Denise S Ryan, Kraig S Bower, Rose K Sia, Marie A Shatos, Robin S Howard, Michael J Mines, Richard D Stutzman, Darlene A Dartt
PURPOSE: To determine whether patients without dry eye preoperatively have an altered conjunctival goblet cell density and mucin secretion postoperatively and to explore what factors affect changes in goblet cell density and mucin secretion. SETTING: The former Walter Reed Army Medical Center, Washington, DC, USA. DESIGN: Prospective nonrandomized clinical study. METHODS: Impression cytology was used to determine conjunctival goblet cell density before and 1 week, 1 month, and 3 months after photorefractive keratectomy (PRK) or laser in situ keratomileusis (LASIK)...
August 2016: Journal of Cataract and Refractive Surgery
Fumika Oya, Takeshi Soma, Yoshinori Oie, Takeshi Nakao, Shizuka Koh, Motokazu Tsujikawa, Naoyuki Maeda, Kohji Nishida
PURPOSE: The purpose of this study was to evaluate visual function and postoperative refractive errors in patients with granular corneal dystrophy type 2 (GCD2) and cataracts who underwent photorefractive keratectomy (PRK) instead of phototherapeutic keratectomy (PTK) following cataract surgery to avoid PTK-induced central island formation and reduce refractive errors after cataract surgery. METHODS: The medical records of 14 eyes from nine patients (one man and eight women; mean age, 69...
October 2016: Graefe's Archive for Clinical and Experimental Ophthalmology
Wen-Shin Lee, Edward E Manche
PURPOSE: To determine the relationship between change in simulated keratometry and corrected refractive error in both wavefront-guided and wavefront-optimized myopic photorefractive keratectomy (PRK), and to determine whether there is a difference in this relationship between these two ablation profiles. METHODS: Sixty-eight patients received wavefront-guided PRK in one eye and wavefront-optimized PRK in the contralateral eye. The changes in simulated keratometry and corresponding refractive changes for both were determined at 1 year postoperatively...
August 1, 2016: Journal of Refractive Surgery
Renato Garcia, Daniel C de Andrade, Manoel J Teixeira, Siro S Nozaki, Samir J Bechara
OBJECTIVE: The cornea is the target of most surgeries for refractive disorders, as myopia. It is estimated that almost 1 million patients undergo corneal refractive surgery each year in the United States. Refractive surgery includes photorefractive keratectomy (PRK) that produces intense postoperative pain. This review presents the main pain mechanisms behind PRK-related pain and the available therapeutic options for its management. METHODS: Data sources included literature of cornea anatomy, treatment of PRK postoperative pain, mechanisms of corneal pain, in 3 electronic databases: Pubmed, Scopus, and Web of Science...
May 2016: Clinical Journal of Pain
Hun Lee, David Sung Yong Kang, Byoung Jin Ha, Jin Young Choi, Eung Kweon Kim, Kyoung Yul Seo, Tae-Im Kim
BACKGROUND: To compare the changes in anterior and posterior corneal elevations after combined transepithelial photorefractive keratectomy (PRK) and accelerated corneal collagen cross-linking (CXL) and after PRK. METHODS: Medical records of 82 eyes of 44 patients undergoing either combined transepithelial PRK and CXL (PRK-CXL group) or transepithelial PRK (PRK group) were examined retrospectively. Changes in anterior and posterior corneal elevations were calculated by fitting an 8...
August 8, 2016: BMC Ophthalmology
Xing Du, Peng Sang, Yuan-Ling Xia, Yi Li, Jing Liang, Shi-Meng Ai, Xing-Lai Ji, Yun-Xin Fu, Shu-Qun Liu
Molecular dynamics (MD) simulations of a subtilisin-like serine protease VPR from the psychrophilic marine bacterium Vibrio sp. PA-44 and its mesophilic homologue, proteinase K (PRK), have been performed for 20 ns at four different temperatures (300, 373, 473, and 573 K). The comparative analyses of MD trajectories reveal that at almost all temperatures, VPR exhibits greater structural fluctuations/deviations, more unstable regular secondary structural elements, and higher global flexibility than PRK. Although these two proteases follow similar unfolding pathways at high temperatures, VPR initiates unfolding at a lower temperature and unfolds faster at the same high temperatures than PRK...
August 2, 2016: Journal of Biomolecular Structure & Dynamics
Yinon Shapira, Igor Vainer, Michael Mimouni, Shmuel Levartovsky, Tzahi Sela, Gur Munzer, Igor Kaiserman
PURPOSE: To evaluate the predictability and accuracy of refractive surgery among adults with myopic anisometropia. METHODS: Consecutive cases of myopic eyes that underwent bilateral laser-assisted in situ keratomileusis (LASIK) or bilateral photorefractive keratectomy (PRK) during a 12-year period in a single center were included. Myopic anisometropia was defined as a difference greater than 1.5 D in spherical equivalent between eyes preoperative. RESULTS: A total of 10,046 paired, operated nonamblyopic eyes of 5023 patients were analyzed...
November 2016: Cornea
Naveed Nilforushan, Pejvak Azadi, Reza Soudi, Yahya Shaheen, Kourosh Sheibani
PURPOSE: To determine whether photorefractive keratectomy (PRK) has a significant effect on optic nerve head (ONH) parameters and peripapillary retinal nerve fiber layer (RNFL) thickness measured by the Heidelberg Retina Tomograph 3 (Heidelberg Engineering GmbH, Heidelberg, Germany) in eyes with low to moderate myopia. METHODS: This prospective, interventional case series, includes 43 consecutive myopic eyes which were assessed on the day of PRK and 3 months postoperatively using the HRT3...
April 2016: Journal of Ophthalmic & Vision Research
Mehrdad Mohammadpour, Hassan Hashemi, Mahmoud Jabbarvand, Kamran Rahmatnejad, Fatemeh Alsadat Sabet
PURPOSE: To evaluate the efficacy of photorefractive keratectomy (PRK) using the advanced personalized treatment (APT) nomogram for correction of moderate to high astigmatism. METHODS: This prospective interventional case series included 60 consecutive eyes of 30 patients undergoing wavefront-guided PRK (Zyoptix 217 Z100 excimer laser, Bausch & Lomb, Munich, Germany) using the APT nomogram and iris registration for myopic astigmatism. Mitomycin-C was applied intraoperatively in all eyes...
April 2016: Journal of Ophthalmic & Vision Research
Kenneth R Taylor, Vasudha A Panday, Matthew C Caldwell, W Matthew Petroll, Douglas A Apsey, Charles D Reilly
PURPOSE: To examine the safety and efficacy of topical anti-interleukin-1 (anti-IL-1) following photorefractive keratectomy (PRK) in rabbit eyes. SETTING: Joint Warfighter Refractive Surgery Center, Lackland Air Force Base, Texas, USA. DESIGN: Experimental study. METHODS: After standard PRK, 48 eyes of 24 New Zealand white rabbits were divided into 4 treatment arms and 1 control arm. Eyes in the treatment arms were randomized to receive fluorometholone 0...
June 2016: Journal of Cataract and Refractive Surgery
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