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hydroxybenzoic acid

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https://www.readbyqxmd.com/read/30409649/in-vitro-metabolism-of-elderberry-juice-polyphenols-by-lactic-acid-bacteria
#1
Annalisa Ricci, Martina Cirlini, Luca Calani, Valentina Bernini, Erasmo Neviani, Daniele Del Rio, Gianni Galaverna, Camilla Lazzi
In this study, ten strains of Lactobacillus were used to assess the in vitro metabolism of elderberry juice polyphenols. Total polyphenolic compounds increased after starter addition, especially with three L. rhamnosus and one L. plantarum strains, of dairy origin: quercetin-3-O-rutinoside was the most abundant compound (from 39.02 ± 5.28 to 127.56 ± 11.34 µg/mL) and hydroxycinnamic acids, flavonols and anthocyanins reached the highest amounts. When L. plantarum were used phenyllactic acids presented a value of 7...
March 15, 2019: Food Chemistry
https://www.readbyqxmd.com/read/30406450/gongronella-sp-w5-elevates-coprinopsis-cinerea-laccase-production-by-carbon-source-syntrophism-and-secondary-metabolite-induction
#2
Jun Hu, Yinliang Zhang, Yong Xu, Qiuying Sun, Juanjuan Liu, Wei Fang, Yazhong Xiao, Ursula Kües, Zemin Fang
When sucrose was used as the carbon source, the Basidiomycete Coprinopsis cinerea showed poor growth and low laccase activity in pure culture, but greatly enhanced the level of laccase activity (>1800 U/L) during coculture with the Mucoromycete Gongronella sp. w5. As a result, the mechanism of laccase overproduction in coculture was investigated by starting from clarifying the function of sucrose. Results demonstrated that Gongronella sp. w5 in the coculture system hydrolyzed sucrose to glucose and fructose by an intracellular invertase...
November 7, 2018: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/30406092/hydrogen-peroxide-based-fluorometric-assay-for-real-time-monitoring-of-sam-dependent-methyltransferases
#3
M Kalim Akhtar, Dhanya Vijay, Saima Umbreen, Chris J McLean, Yizhi Cai, Dominic J Campopiano, Gary J Loake
Methylated chemicals are widely used as key intermediates for the syntheses of pharmaceuticals, fragrances, flavors, biofuels and plastics. In nature, the process of methylation is commonly undertaken by a super-family of S-adenosyl methionine-dependent enzymes known as methyltransferases. Herein, we describe a novel high throughput enzyme-coupled assay for determining methyltransferase activites. Adenosylhomocysteine nucleosidase, xanthine oxidase, and horseradish peroxidase enzymes were shown to function in tandem to generate a fluorescence signal in the presence of S-adenosyl-L-homocysteine and Amplex Red (10-acetyl-3,7-dihydroxyphenoxazine)...
2018: Frontiers in Bioengineering and Biotechnology
https://www.readbyqxmd.com/read/30399815/x-ray-absorption-spectrum-combined-with-deep-neural-network-for-on-line-detection-of-beverage-preservatives
#4
Weifeng Hu, Siyuan Chen, Yuqi Li, Qian Wang, Zheng Fang
Aiming at the problem that the common preservative detection methods are too cumbersome and costly, a rapid on-line detection method based on X-ray absorption spectrum (XAS) for beverage preservatives is proposed. Benzoic acid, potassium sorbate, sodium dehydrogenate, and propyl p -hydroxybenzoate were selected to form standard concentration and excess concentration solutions. XAS data were collected by an X-ray spectrum detection system, and the leave one out cross-validation method was used to divide the data set...
October 2018: Review of Scientific Instruments
https://www.readbyqxmd.com/read/30399546/metabolic-changes-induced-by-manganese-in-chamomile
#5
Jozef Kováčik, Sławomir Dresler, Magdalena Wójciak-Kosior, Juraj Hladký, Petr Babula
Manganese (Mn) uptake and toxicity in chamomile (Matricaria chamomilla) and changes of phenolic metabolites in plants grown in the soil (1000 μM Mn2+ ) or hydroponic culture (100 or 1000 μM Mn2+ ) were studied. Under soil cultivation, Mn excess reduced growth and induced symptoms of oxidative stress (including total ROS, hydroxyl radical and lipid peroxidation as detected by fluorescence microscopy), concomitantly with depletion of non-protein thiols and ascorbic acid. Total soluble phenols and individual phenolic acids were rather depleted (p-coumaric, chlorogenic, and protocatechuic acids) or unaltered (vanillic and caffeic acids)...
October 29, 2018: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/30392093/production-of-methylparaben-in-escherichia-coli
#6
Jillian M Hagel, Xue Chen, Peter J Facchini
Since the 1930s, parabens have been employed widely as preservatives in food, pharmaceutical, and personal care products. These alkyl esters of benzoic acid occur naturally in a broad range of plant species, where they are thought to enhance overall fitness through disease resistance and allelopathy. Current manufacture of parabens relies on chemical synthesis and the processing of 4-hydroxybenzoate as a precursor. A variety of bio-based production platforms have targeted 4-hydroxybenzoate for a greener alternative to chemical manufacturing, but parabens have yet to be made in microbes...
November 3, 2018: Journal of Industrial Microbiology & Biotechnology
https://www.readbyqxmd.com/read/30386935/design-synthesis-and-biological-activity-of-hydroxybenzoic-acid-ester-conjugates-of-phenazine-1-carboxylic-acid
#7
Xiang Zhu, Linhua Yu, Min Zhang, Zhihong Xu, Zongli Yao, Qinglai Wu, Xiaoying Du, Junkai Li
We prepared 16 novel hydroxybenzoic acid ester conjugates of phenazine-1-carboxylic acid (PCA) and investigated their biological activity. Most of the synthesized conjugates displayed some level of fungicidal activities in vitro against five phytopathogenic fungi. Nine conjugates 5b, 5c, 5d, 5e, 5h, 5i, 5m, 5n and 5o (EC50 between 3.2 μg/mL and 14.1 μg/mL) were more active than PCA (EC50 18.6 μg/mL) against Rhizoctonia solani. Especially conjugate 5c showed the higher fungicidal activity against Rhizoctonia solani which is 6...
November 1, 2018: Chemistry Central Journal
https://www.readbyqxmd.com/read/30380657/prospective-association-between-total-and-specific-dietary-polyphenol-intakes-and-cardiovascular-disease-risk-in-the-nutrinet-sant%C3%A3-french-cohort
#8
Solia Adriouch, Aurélie Lampuré, Anouar Nechba, Julia Baudry, Karen Assmann, Emmanuelle Kesse-Guyot, Serge Hercberg, Augustin Scalbert, Mathilde Touvier, Léopold K Fezeu
BACKGROUND: Epidemiological and experimental evidence support a protective effect of dietary polyphenols on chronic diseases, but high quality longitudinal data are needed, including details on categories of polyphenols. Our objective was to investigate the prospective association between total and individual classes and subclasses of dietary polyphenols and the risk of major cardiovascular disease in the NutriNet-Santé cohort. METHODS: A total of 84,158 participants, who completed at least three 24 h dietary records, were included between May 2009 and June 2017...
October 29, 2018: Nutrients
https://www.readbyqxmd.com/read/30367616/drought-stress-enhances-nutritional-and-bioactive-compounds-phenolic-acids-and-antioxidant-capacity-of-amaranthus-leafy-vegetable
#9
Umakanta Sarker, Shinya Oba
BACKGROUND: Bioactive compounds, vitamins, phenolic acids, flavonoids of A. tricolor are the sources of natural antioxidant that had a great importance for the food industry as these detoxify ROS in the human body. These natural antioxidants protect human from many diseases such as cancer, arthritis, emphysema, retinopathy, neuro-degenerative cardiovascular diseases, atherosclerosis and cataracts. Moreover, previous literature has shown that drought stress elevated bioactive compounds, vitamins, phenolics, flavonoids and antioxidant activity in many leafy vegetables...
October 26, 2018: BMC Plant Biology
https://www.readbyqxmd.com/read/30355963/carbon-consumption-patterns-of-microbial-communities-associated-with-peltigera-lichens-from-a-chilean-temperate-forest
#10
Katerin Almendras, Diego Leiva, Margarita Carú, Julieta Orlando
Lichens are a symbiotic association between a fungus and a green alga or a cyanobacterium, or both. They can grow in practically any terrestrial environment and play crucial roles in ecosystems, such as assisting in soil formation and degrading soil organic matter. In their thalli, they can host a wide diversity of non-photoautotrophic microorganisms, including bacteria, which play important functions and are considered key components of the lichens. In this work, using the BioLog® EcoPlate system, we studied the consumption kinetics of different carbon-sources by microbial communities associated with the thallus and the substrate of Peltigera lichens growing in a Chilean temperate rain forest dominated by Nothofagus pumilio ...
October 24, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/30328001/preparation-optimization-and-pharmacological-evaluation-of-99m-tc-4-hydroxy-3-2-hydroxy-3-methoxybenzylideneamino-benzoic-acid-complex-as-a-novel-potential-radiopharmaceutical-agent-with-hepatobiliary-excretion
#11
Muhammad Usman Akbar
Schiff base ligands are biologically active compounds in having antimicrobial, antiviral and antitumor activities etc. In this study, we have synthesized a Schiff base ligand namely 4-hydroxy-3-(2-hydroxy-3-methoxybenzylideneamino) benzoic acid, by reacting 3-amino-4-hydroxybenzoic acid and 2-hydroxy-3-methoxy benzaldehyde in the presence of acetic acid and refluxing it. The resulting base ligand was characterized on HPLC and used for radiolabelling with technetium-99m. The ligand 4-hydroxy-3-(2-hydroxy-3-methoxybenzylideneamino) benzoic acid was labelled with 99m Tc at pH 7, while reacting 230 µg of ligand with 15 mCi of 99m TcO- 4 for 10 min at room temperature...
October 16, 2018: Molecular Biology Reports
https://www.readbyqxmd.com/read/30317427/chemical-composition-and-biological-activity-of-extracts-from-fruiting-bodies-and-mycelial-cultures-of-fomitopsis-betulina
#12
Katarzyna Sułkowska-Ziaja, Agnieszka Szewczyk, Agnieszka Galanty, Joanna Gdula-Argasińska, Bożena Muszyńska
Fomitopsis betulina (Bull.) B.K. Cui, M.L. Han & Y.C. Dai has been used for medicinal purposes for over 5000 years. Numerous studies have confirmed the biological activity of compounds found in this species. The purpose of this study was a comparative analysis of selected groups of metabolites in the extracts from fruiting bodies and mycelial cultures. Phenolic acids (syringic, gallic, p-hydroxybenzoic, 3,4-dihydrophenylacetic), indole compounds (L-tryptophan, 5-hydroxy-L-tryptophan, 5-methyltryptamine), sterols (ergosterol, ergosterol peroxide, hexestrol, cholecalciferol), and triterpenes (betulinic acid, betulin) were determined quantitatively by high performance liquid chromatography with UV-Vis/DAD detection, while fatty acids were assessed with the gas chromatography method...
October 13, 2018: Molecular Biology Reports
https://www.readbyqxmd.com/read/30309561/a-value-added-approach-to-improve-the-nutritional-quality-of-soybean-meal-byproduct-enhancing-its-antioxidant-activity-through-fermentation-by-bacillus-amyloliquefaciens-swjs22
#13
Juan Yang, Xiao-Bin Wu, Hong-Lei Chen, Dongxiao Sun-Waterhouse, Hong-Bo Zhong, Chun Cui
The action of β-glucosidase and protease of Bacillus amyloliquefaciens SWJS22 in the fermentation of soybean meal caused a significant increase 1): in total phenolic and flavonoid contents with two-fold or higher, largely associated with daidzein, glycitein, genistein, protocatechuic, and p-hydroxybenzoic, gallic acids; 2): the amount of peptides <3 kDa, maillard reaction intermediate and maillard reaction product with five-, three- and twenty-one-fold, respectively. The significant increase in the amount of antioxidant components in the lyophilised fermented soybean meal supernatant (LFSMS) was associated with the improved antioxidant activity...
January 30, 2019: Food Chemistry
https://www.readbyqxmd.com/read/30298076/targeted-metabolic-profiling-indicates-apple-rootstock-genotype-specific-differences-in-primary-and-secondary-metabolite-production-and-validate-quantitative-contribution-from-vegetative-growth
#14
Rachel Leisso, Dave Rudell, Mark Mazzola
Previous reports regarding rhizodeposits from apple roots are limited, and complicated by microbes, which readily colonize root systems and contribute to modify rhizodeposit metabolite composition. This study delineates methods for collection of apple rhizodeposits under axenic conditions, indicates rootstock genotype-specific differences and validates the contributions of vegetative activity to rhizodeposit quantity. Primary and phenolic rhizodeposit metabolites collected from two apple rootstock genotypes, G935 and M26, were delineated 2 months after root initiation by utilizing gas chromatography/liquid chromatography-mass spectrometry (GC/LC-MS), respectively...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/30292954/new-phenolic-halogenated-disinfection-byproducts-in-simulated-chlorinated-drinking-water-identification-decomposition-and-control-by-ozone-activated-carbon-treatment
#15
Yan Huang, Huan Li, Qing Zhou, Aimin Li, Chendong Shuang, Qiming Xian, Bin Xu, Yang Pan
Recently, 13 new phenolic halogenated disinfection byproducts (DBPs) were discovered and confirmed in chlorinated drinking water using ultra performance liquid chromatography/electrospray ionization-triple quadrupole mass spectrometry (UPLC/ESI-tqMS), which have been attracting a growing concern due to their higher chronic cytotoxicity, developmental toxicity, and growth inhibition compared with commonly known aliphatic DBPs. In this study, another 12 new phenolic halogenated DBPs were detected and identified in simulated chlorinated drinking water samples, including two monohalo-4-hydroxybenzaldehydes, two monohalo-4-hydroxybenzoic acids, three monohalo-salicylic acids, and five mono/di/trihalo-phenols...
September 26, 2018: Water Research
https://www.readbyqxmd.com/read/30289585/development-of-an-lc-ms-ms-method-for-monitoring-long-term-exposure-to-the-parabens
#16
Sung-Hee Cho, Han-Na Song
RATIONAL: Parabens, the alkyl esters of 4-hydroxybenzoic acid, are a family of compounds widely used as preservatives in cosmetic products, including for children, and some are permitted in foods. Parabens are known to be weak endocrine disruptor because they interfere with the function of endogenous hormones through binding to estrogen receptors. Therefore, the levels of parabens in biological samples indicate endocrine disruptive exposure. In particular, hair samples can provide information on accumulated exposure to parabens...
October 5, 2018: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/30287788/time-dependent-degradation-of-polyphenols-from-thermally-processed-berries-and-their-in-vitro-antiproliferative-effects-against-melanoma
#17
Zorița Diaconeasa
Polyphenols are natural occurring micronutrients that can protect plants from natural weathering and are also helpful to humans. These compounds are abundantly found in fruits or berries. Because of berry seasonal availability and also due to their rapid degradation, people have found multiple ways to preserve them. The most common options are freezing or making jams. Polyphenol stability, during processing is a continuous challenge for the food industry. There are also multiple published data providing that they are sensitive to light, pH or high temperature, vectors which are all present during jam preparation...
October 4, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/30283947/inhibition-by-microbial-metabolites-of-chinese-dark-tea-of-age-related-neurodegenerative-disorders-in-senescence-accelerated-mouse-prone-8-samp8-mice
#18
Shuxian Cai, Heng Yang, Beibei Wen, Kun Zhu, Xin Zheng, Jianan Huang, Yingzi Wang, Zhonghua Liu, Pengfei Tu
Dark tea has a significant effect on the prevention and treatment of age-related degenerative diseases. At present, further exploration of its functional mechanisms is delayed because of the complexity of post-fermentation microbial metabolites during the production phase. In this study, new isolated microbial metabolites extracted from dark tea were used to explore the neuroprotective effects, and they also helped allow further exploration of the mechanism of dark tea. Taking senescence-accelerated mouse prone 8 (SAMP8) mice as a biological model, we examined the protective effect on brain neurons of post-fermentation microbial metabolites which were extracted from dark tea...
October 17, 2018: Food & Function
https://www.readbyqxmd.com/read/30277648/high-production-dairy-cattle-exhibit-different-rumen-and-fecal-bacterial-community-and-rumen-metabolite-profile-than-low-production-cattle
#19
Yingyu Mu, Xueyan Lin, Zhonghua Wang, Qiuling Hou, Yun Wang, Zhiyong Hu
Our aim was to simultaneously investigate the gut bacteria typical characteristic and conduct rumen metabolites profiling of high production dairy cows when compared to low-production dairy cows. The bacterial differences in rumen fluid and feces were identified by 16S rDNA gene sequencing. The metabolite differences were identified by metabolomics profiling with liquid chromatography mass spectrometry (LC-MS). The results indicated that the high-production dairy cows presented a lower rumen bacterial richness and species evenness when compared to low-production dairy cows...
September 11, 2018: MicrobiologyOpen
https://www.readbyqxmd.com/read/30267830/inhibitors-of-the-nmda-nitric-oxide-signaling-pathway-protect-against-neuronal-atrophy-and-synapse-loss-provoked-by-l-alpha-aminoadipic-acid-treated-astrocytes
#20
J David, E O'Toole, K O'Reilly, G Thuery, N Assmann, D Finlay, A Harkin
The impact of treating astrocytes with the astrocytic toxin l-alpha amino adipic acid (L-AAA) on neuronal outgrowth, complexity and synapse formation was assessed, using a model of astrocyte-neuronal interaction. Treatment of rat primary cortical neurons with conditioned media (CM) derived from astrocytes treated with L-AAA reduced neuronal complexity and synapse formation. L-AAA provoked a reduction in the expression of glial fibrillary acid protein (GFAP) and a reduction in ATP-linked mitochondrial respiration in astrocytic cells...
November 10, 2018: Neuroscience
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