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hydroxybenzoic acid

Shuxia Qian, Yanping Wang, Xiaoling Zhang
Although histamine inhibitors have been used in the motility-associated vertigo, the link between histamine and sleep deprivation (SD)-induced vertigo has not been clearly demonstrated. The histamine plasma levels were assayed in the SD volunteers before SD and 24 h after SD. Pinnacle's automated sleep deprivation system was used to establish the female C57BL/6 mice SD model. Histidine decarboxylase inhibitor 4-bromo-3-hydroxybenzoic acid (BHOA), and antihistamine diphenhydramine (DPHM) were injected intraperitoneally to test their effects on SD-induced vertigo...
January 15, 2019: Journal of Molecular Neuroscience: MN
Jean-Christophe Cocuron, Maria Isabel Casas, Fan Yang, Erich Grotewold, Ana Paula Alonso
Plants accumulate several thousand of phenolic compounds, including lignins and flavonoids, which are mainly synthesized through the phenylpropanoid pathway, and play important roles in plant growth and adaptation. A novel high-throughput ultra-high performance liquid chromatography tandem mass spectrometry (UHPLC-MS/MS) method was established to quantify the levels of 19 flavonoids and 15 other phenolic compounds, including acids, aldehydes, and alcohols. The chromatographic separation was performed in 10 min, allowing for the resolution of isomers such as 3-, 4-, and 5-chlorogenic acids, 4-hydroxybenzoic and salicylic acids, isoorientin and orientin, and luteolin and kaempferol...
December 26, 2018: Journal of Chromatography. A
Christoph Koch, Milen Nachev, Julia Klein, Daniel Köster, Oliver J Schmitz, Torsten C Schmidt, Bernd Sures
Monomeric brominated flame retardants often pose risks to the environment. The new group of polymeric flame retardants is claimed to be a safer alternative due to their high molecular weight and persistence by design. Within this publication, the degradation of a commercially widely applied example of this group-the polymer "Polymeric FR"-was studied during UV irradiation and long-term exposure to heat (60 °C) for up to 36 weeks. Both treatments led to a variety of degradation products, which might have potentially adverse environmental effects and an increased mobility compared to the mother polymer...
January 9, 2019: Environmental Science & Technology
Cristiano Dietrich Ferreira, Valmor Ziegler, Jorge Tiago Schwanz Goebel, Jessica Fernanda Hoffmann, Ivan Ricardo Carvalho, Fabio Clasen Chaves, Mauricio de Oliveira
The changes in phenolic acid and isoflavone profile of soybean genotypes (Nidera 5909 RR and BMX Força RR) dried at different temperatures and stored for 12 months were investigated. In both cultivars, there was a reduction of the germination capacity and an increase of fungal incidence with the increase of drying temperature and storage time. Multivariate analysis of phenolic acids allowed for the differentiation among treatments. Cultivar Nidera 5909 RR, dried at 110 °C, showed an interaction with characters of greater relevance for differentiation, being influenced by the increase of bound coumaric, and syringic, and free-hydroxybenzoic, syringic and coumaric acids...
January 9, 2019: Journal of Agricultural and Food Chemistry
Qiang Feng, Hualong He, Tiantao Gao, Qiangsheng Zhang, Zhihao Liu, Xin Tao, Yongxia Zhu, Lidan Zhang, Luoting Yu
The histone lysine methyltransferase EZH2 has been reported to play important roles in cancer aggressiveness, metastasis and poor prognosis. In this study, a series of benzomorpholine derivatives were synthesized and biologically evaluated as EZH2 inhibitors. The target compounds were obtained in good yields from 3-amino-5-bromo-2-hydroxybenzoic acid via cyclization, Suzuki coupling and amidation as the key steps. A preliminary optimization study led to the discovery of several potent novel EZH2 inhibitors (6b, 6c, 6x and 6y)...
January 5, 2019: Molecular Diversity
Yujing Sun, Wenyang Tao, Haizhi Huang, Xingqian Ye, Peilong Sun
With in-vitro digestion and human intestinal HepG2 cells, we analyzed the bioaccessibility and cell uptake of phytochemicals and determined the cellular antioxidant capacity (CAA) of fresh eating citrus fruits. The results showed that CAA of citrus fruits was higher in digesta than in extracts, and the CAA is strongly correlated with naringenin and beta-carotene uptake (p < 0.05). During in vitro digestion, vanillic acid and p-coumaric decreased, and ferulic acid increased in all citrus fruits significantly (p < 0...
May 1, 2019: Food Chemistry
Sayeh Sinichi, Ana Victoria Legorreta Siañez, Levente L Diosady
Nanofiltration (NF) (MWCO 150-300 Da) was evaluated for the recovery of phenolic compounds from the wastewater from the production of yellow mustard protein isolates. Rejection coefficients of 0.70 and 0.87 and transmembrane fluxes of 51.3 L/hm2 and 28.8 L/hm2 were observed under alkaline and acidic conditions, respectively. At low pH, 77% of the phenolic compounds fed to the process were recovered in the retentate. Combination of diafiltration (DF) with NF was beneficial only when processing at low pH...
January 2019: Food Research International
Gabriele Rocchetti, Francesca Blasi, Domenico Montesano, Silvia Ghisoni, Maria Carla Marcotullio, Stefano Sabatini, Lina Cossignani, Luigi Lucini
The impact of different extraction methods, namely maceration, homogenizer-assisted extraction, rapid solid-liquid dynamic extraction, microwave-assisted extraction and ultrasound-assisted extraction, on polyphenols of Moringa oleifera leaves was studied. The phenolic composition of alcoholic (methanol 100%) and hydroalcoholic (methanol/water 50:50, v/v) extracts was compared by using an untargeted metabolomics-based profiling approach followed by multivariate statistics. With this aim, ultra-high-pressure liquid chromatography coupled to a quadrupole-time-of-flight mass spectrometry was used to profile phenolic compounds under the different extraction conditions...
January 2019: Food Research International
Saeme Babatabar, Seyed Morteza Zamir, Seyed Abbas Shojaosadati, Bagher Yakhchali, Ali Babaei Zarch
Bisphenol A (BPA) is a toxic compound emitting to the environment mainly by polycarbonate production facilities. In this research, BPA with the initial concentrations in the range of 1-40 mg l-1 was degraded by Ralstonia eutropha. The bacteria were unable to use BPA as the sole carbon source. Therefore, resting and growing cells of phenol-adapted R. eutropha were used for cometabolic biodegradation of BPA with phenol at the concentration of 100 mg l-1 . The optimum initial concentrations of BPA were 20 mg l-1 in both approaches of cometabolism...
December 28, 2018: Journal of Bioscience and Bioengineering
Chetan B Aware, Ravishankar R Patil, Govind D Vyavahare, Swati T Gurme, Jyoti P Jadhav
OBJECTIVE: This investigation was undertaken to optimize the effective extraction of total phenolics content (TPC), total flavonoids content (TFC), and antioxidant activity from the Mucuna macrocarpa (MM) beans. An ultrasound-assisted extraction (UAE) technique with water as an effective solvent was proposed for the response surface methodology (RSM) optimization. METHODS: A three-level, two-factor central composite design (CCD) was employed to reveal the optimal points of variables...
December 27, 2018: Journal of the American College of Nutrition
Mayakrishnan Prabakaran, Ill-Min Chung, Na-Young Son, Hee-Youn Chi, So-Yeon Kim, Yu-Jin Yang, Chang Kwon, Yeon-Ju An, Ateeque Ahmad, Seung-Hyun Kim
Rice ( Oryza sativa L.) contains generous amounts of carbohydrates, proteins, vitamins, and dietary fibers, in addition to secondary metabolites such as phenols and flavonoids that act as antioxidants. The phenolic compounds detected in rice (organic rice (OR), conventional rice (CR), and pesticide-free rice (PFR)), namely, protocatechuic, gentisic, p -hydroxybenzoic, p -coumaric, ferulic, salicylic, and caffeic acids, are notable free radical scavengers. The sum of these phenolic compounds was found to be higher in PFR, followed by CR and OR ( p < 0...
December 25, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Ecem Evrim Çelik, Jose Manuel Amigo Rubio, Mogens Larsen Andersen, Vural Gökmen
The interactions between dietary fiber (DF)-bound antioxidants and free antioxidants, with different substitution patterns of -OH and -OCH3 groups on their aromatic rings has been investigated. The activity and efficiency of these interactions were examined with a structural approach. Whole wheat (WW) DF-bound antioxidants and 21 hydroxycinnamic acid/hydroxybenzoic acids (HCA/HBA) were used in the experimental studies. Studies were performed in liposome and aqueous media by monitoring lipid oxidation and scavenging of DPPH radical in the presence of WW-bound antioxidants and HCA/HBA derivatives...
April 25, 2019: Food Chemistry
Erna Karalija, Adisa Parić, Sabina Dahija, Renata Bešta-Gajević, Sanja Ćavar Zeljković
Detailed analysis of phenolic composition and antioxidant and antimicrobial activities of Verbascum glabratum subsp. bosnense (K. Malý) Murb., an endemic species of southeastern Dinaric Alps was performed for the first time. The phenolic composition measured via UHPLC-MS/MS of four extract with different polarity suggested this plant species is very rich in both phenolic acids and flavonoids. Ethanol extract was chemically the most versatile containing 12 compounds with quercitrin and rosmarinic acid as the majors, while water extracts were rich in 4-hydroxybenzoic acid, salicylic acid, morin, and apigenin...
December 23, 2018: Natural Product Research
YuXi Chen, Wei Chen, Yan Lan, KaiTeng Wang, YongChen Wu, XiaoLi Zhong, KaiYang Ying, JunYing Li, GuiDi Yang
An ultra-performance liquid chromatography-triple quadrupole mass spectrometry for the determination of free and bound phenolic acids in tobacco plant and soil was developed. A simple solid phase extraction, which used Polar Enhanced Polymer column as stationary phase and methanol as mobile phase, was used for clean-up of bound phenolic acids, and a liquid phase extraction using chloroform as solvent was used to purify free phenolic acids. With our method, 18 phenolic acids in rhizosphere soil of continuous cropping flue-cured cultivar k326 were separated and determined within 6 min with recoveries of 82∼107% and relative standard deviations (n = 5) of 1...
December 23, 2018: Journal of Separation Science
Ying Li, Shunqing Xu, Yuanyuan Li, Bin Zhang, Wenqian Huo, Yingshuang Zhu, Yanjian Wan, Tongzhang Zheng, Aifen Zhou, Zhong Chen, Zheng Huang, Jie Hu, Wenxin Zhang, Xianliang Wang, Dan Ye, Wei Xia
Increasing evidence suggests a potential role of endocrine disrupting chemicals (EDCs) in inducing gestational diabetes mellitus (GDM). However, as far as we know, no study has examined the associations between GDM and exposure to parabens, a kind of EDCs. In this study, we explored the association between urinary parabens of pregnant women and GDM and studied the modification effect of prepregnancy body mass index (BMI). Urine samples were collected from 696 pregnant women and parabens were measured, including four alkyl side chain substituted para-hydroxybenzoic acid ester, substituents varying from methyl to butyl (abbreviates as MeP, EtP, PrP and BuP), and benzyl substituted para-hydroxybenzoic acid ester (BzP)...
December 15, 2018: Environmental Research
Natalia Casado, Sonia Morante-Zarcero, Damian Perez-Quintanilla, José S Câmara, Isabel Sierra
A wormhole-like mesostructured silica was synthesized and modified with octadecylsilane (C18) groups. The resulting hybrid material (HMS-C18) was characterized and evaluated as sorbent for simultaneous extraction of 20 polyphenols from mixed fruit-vegetables juices and smoothies by dispersive solid-phase extraction (dSPE). The samples were first subjected to solvent extraction followed by dSPE procedure. The extraction step was optimized and combined with a reversed-phase ultra-high-performance liquid chromatography method coupled to ion-trap tandem mass spectrometry (UHPLC-IT-MS/MS), which was also optimized...
December 20, 2018: Journal of Agricultural and Food Chemistry
Jun Cao, Huimin Wang, Wei Zhang, Fuliang Cao, Geli Ma, Erzheng Su
Ginkgo biloba leaves have various health benefits due to the presence of bioactive compounds such as polyprenyl acetates, flavonoids, and terpene trilactones. However, there is little literature reported on the aromatic acids in Ginkgo biloba leaves. In this work, five aromatic acids including shikimic acid (SA), 6-hydroxykynurenic acid (6-HKA), protocatechuic acid (PA), gallic acid (GAA), and p -hydroxybenzoic acid (PHBA) were simultaneously extracted from Ginkgo biloba leaves by employing the green deep eutectic solvents (DESs)...
December 5, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Ewa Białecka-Florjańczyk, Agata Fabiszewska, Bartłomiej Zieniuk
Phenolic acids are secondary plant metabolites belonging to polyphenol classes, widely spread throughout the plant kingdom. The name "phenolic acids", in general, describes phenols that possess one carboxylic acid functionality and they could be divided into three major subclasses: hydroxybenzoic, hydroxycinnamic and hydroxyphenylacetic acids. The great interest in phenolic acids is associated with their high potential for food preservation (antioxidant and antimicrobial activity) and, last but not least, high therapeutic potential...
December 17, 2018: Current Pharmaceutical Biotechnology
Melinda Fogarasi, Sonia Ancuţa Socaci, Francisc Vasile Dulf, Zorița Maria Diaconeasa, Anca Corina Fărcaș, Maria Tofană, Cristina Anamaria Semeniuc
This study aimed to determine the chemical composition, fatty acids, volatile profile and phenolic compounds profiles from five wild edible mushrooms ( Agaricus bisporus, Pleurotus ostreatus, Cantharellus cibarius, Boletus edulis, Lactarius piperatus ) from Romania. The results indicated that the dried fruiting bodies of selected mushrooms were rich in proteins (36.24 g/100 g dw- Boletus edulis ) and carbohydrates (62.45 g/100 g dw- Lactarius piperatus ). 4-Hydroxybenzoic acid and cinnamic acid, were the main phenolic compound present in all selected species...
December 11, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Fahimeh Zeraatkar Kashani, Sayed Mehdi Ghoreishi, Asma Khoobi, Morteza Enhessari
An electrochemical sensor is described for the simultaneous determination of ortho-hydroxybenzoic acid (OHB) and para-hydroxybenzoic acid (PHB). The sensor consists of a carbon paste electrode modified with nickel titanate nanoceramics (NiTiO3 /CPE). The NiTiO3 nanoceramics and the nanostructured modified CPE were characterized by X-ray diffraction, scanning electron microscopy, transmission electron microscopy, electrochemical impedance spectroscopy and cyclic voltammetry. Differential pulse voltammetry indicates that the response to OHB (best measured at 0...
December 10, 2018: Mikrochimica Acta
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