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hydroxybenzoic acid

Takahisa Kogure, Masayuki Inui
Recent progress in synthetic and systems metabolic engineering technologies has explored the potential of microbial cell factories for the production of industrially relevant bulk and fine chemicals from renewable biomass resources in an eco-friendly manner. Corynebacterium glutamicum, a workhorse for industrial amino acid production, has currently evolved into a promising microbial platform for bioproduction of various natural and non-natural chemicals from renewable feedstocks. Notably, it has been recently demonstrated that metabolically engineered C...
August 14, 2018: Applied Microbiology and Biotechnology
T R Monisha, Mukram Ismailsab, Ramesh Masarbo, Anand S Nayak, T B Karegoudar
A bacterium Stenotrophomonas sp. TRMK2 capable of utilizing cinnamic acid was isolated from agro-industrial waste by enrichment culture technique. This strain completely utilizes 5 mM cinnamic acid within 18 h of incubation. The different metabolites formed during the degradation of cinnamic acid were characterized by GC-HRMS. The involvement of various enzymes, namely cinnamate reductase, 3-phenylpropionic acid hydroxylase, p -hydroxybenzoic acid hydroxylase and protocatechuate 3,4-dioxygenase in cinnamic acid degradation was demonstrated...
August 2018: 3 Biotech
Bei-Bei He, Xu-Liang Bu, Ting Zhou, Shu-Ming Li, Minjuan Xu, Jun Xu
Prenylated aromatic compounds are important intermediates in the biosynthesis of bioactive molecules such as secondary metabolites from plants, ubiquinone from prokaryotes and meroterpenoids from sponges. Biosynthesis of prenylated aromatic compounds using prokaryotic microorganisms has attracted increasing attention in the field of synthetic biology. In this study, we demonstrated that the production of 3-geranyl-4-hydroxybenzoic acid (GBA) and a variety of GBA analogs was feasible in a metabolically engineered E...
August 13, 2018: ACS Synthetic Biology
Aicha Hennia, Maria Graça Miguel, Said Nemmiche
Myrtus communis L. (myrtle) and Myrtus nivellei Batt. & Trab. (Saharan myrtle) have been used in folk medicine for alleviating some ailments. M. communis is largely distributed in the Mediterranean Basin, whereas M. nivellei is confined in specific zones of the central Saharan mountains. The chemical composition and antioxidant activity of berry and leaf extracts isolated from myrtle are deeply documented, whereas those isolated from Saharan myrtle extracts are less studied. In both species, the major groups of constituents include gallic acid derivatives, flavonols, flavonol derivatives, and hydroxybenzoic acids...
August 11, 2018: Medicines (Basel, Switzerland)
Li-Wei Chiu, Matthew J Heckert, You You, Nicholas Albanese, Tamara Fenwick, Daniel L Siehl, Linda A Castle, Yumin Tao
Auxin homeostasis is a highly-regulated process that must be maintained to allow auxin to exert critical growth and developmental controls. Auxin conjugase and hydrolase family proteins play important roles in auxin homeostasis through means of storage, activation, inactivation, response inhibition, and degradation of auxins in plants. We systematically evaluated 60 GH3 proteins from diverse plant species for amino acid conjugation activity with the known substrates jasmonic acid (JA), indole-3-acetic acid (IAA), and 4-hydroxybenzoate (4-HBA)...
August 8, 2018: Plant & Cell Physiology
Mehmet Ali Demirci, Yaşar Ipek, Fatih Gul, Tevfik Ozen, Ibrahim Demirtas
Apple pulps (AP) were obtained as a side product in fruit juice factories and contains valuable phenolic compounds. The dried AP was subjected to extraction with water, ethyl acetate (APEA) and n-butanol (APBU), respectively. 5-Hydroxymaltol (5-HM) was isolated and confirmed by NMR techniques. The HPLC-TOF/MS analysis revealed the presence of 16 components including major components of morine, gentisic, 4-hydroxybenzoic, vanillic and fumaric acid. The antioxidant activities were evaluated with total antioxidant activity, reducing power, inhibition of lipid peroxidation, metal chelating, free radical and H2 O2 scavenging activities...
December 15, 2018: Food Chemistry
Chiing-Chang Chen, Jing-Ya Fu, Jia-Lin Chang, Shiuh-Tsuen Huang, Tsung-Wen Yeh, Jiun-Ting Hung, Peng-Hao Huang, Fu-Yu Liu, Li-Wen Chen
This is the first paper to report a series of bismuth oxyfluoride/bismuth oxyiodide (BiOp Fq /BiOx Iy ) nanocomposites with different F/I molar ratios, pH values, and reaction temperatures that were synthesized through a template-free and controlled hydrothermal method. These nanocomposites were characterized through scanning electron microscope energy dispersive microscopy (SEM-EDS), transmission electron microscopy (TEM), X-ray diffraction (XRD), Fourier-transform infrared (FT-IR), X-ray photoelectron spectroscopy (XPS), Brunauer-Emmett-Teller (BET), and diffuse reflectance spectroscopy (DRS)...
August 3, 2018: Journal of Colloid and Interface Science
Anna Z Pollack, Sunni L Mumford, Jenna R Krall, Andrea E Carmichael, Lindsey A Sjaarda, Neil J Perkins, Kurunthachalam Kannan, Enrique F Schisterman
BACKGROUND: Little is known about the associations of bisphenol A, chlorophenols, benzophenones, and parabens with reproductive hormone levels in women. Our goal was to evaluate the associations between repeated measures of these chemicals and their mixtures with reproductive hormones in women. METHODS: Longitudinal urine samples from healthy, premenopausal women (n = 143 with 3-5 urine samples each) were measured for bisphenol A, five chlorophenols (2,4-dichlorophenol (2,4-DCP), 2,5-dichlorophenol, 2,4,5-trichlorophenol, 2,4,6-trichlorophenol, triclosan), two ultraviolet (UV) filters (benzophenone-1, benzophenone-3), and eight parabens and their metabolites (benzyl, butyl, ethyl, heptyl, methyl, propyl, 4-hydroxybenzoic acid (4-HB), 3,4-dihydroxybenzoic acid (3,4-DHB)) over two menstrual cycles...
August 6, 2018: Environment International
Sok Sian Liew, Wan Yong Ho, Swee Keong Yeap, Shaiful Adzni Bin Sharifudin
Background: Citrus sinensis peels are usually discarded as wastes; however, they are rich sources of Vitamin C, fibre, and many nutrients, including phenolics and flavonoids which are also good antioxidant agents. This study aimed to examine phytochemical composition and antioxidant capabilities of C. sinensis peel extracted conventionally with different methanol/water, ethanol/water, and acetone/water solvents. Methods: C. sinensis peels were subjected to extraction with 100%, 70% and 50% of methanol, ethanol, and acetone, respectively, as well as hot water extraction...
2018: PeerJ
Zhenkun Mao, Xiaoning Qin, Zilin Chen
A novel anion-exchange organic polymer monolithic column based on monomers N-benzylquininium chloride and acrylamide was firstly prepared by in situ copolymerization for capillary electrochromatography. Moreover, N-benzylquininium was firstly introduced as a strong anion-exchange functional group. A relatively strong anodic electroosmotic flow (EOF) was obtained in the pH values from 4.0 to 9.0, which was in the same direction with the electrophoretic mobility of acid compounds. Hence, the anion-exchange monolithic column was very suitable for the rapid separation of acid compounds...
August 6, 2018: Electrophoresis
Chunyang Liao, Kurunthachalam Kannan
Parabens are used as preservatives in many consumer products, and human exposure to these chemicals has been a public concern. In this study, mollusks ( n = 186), collected from the Chinese Bohai Sea during 2006-2015, were analyzed for six parabens and their five metabolites. The total concentration of parabens was in the range of 2.66-299 ng/g dw (geometric mean: 24.1). Methyl paraben and 4-hydroxybenzoic acid were the predominant parent and metabolic parabens, respectively found in mollusks. Mollusk species, Mactra veneriformis, Mytilus edulis, and Cyclina sinensis contained elevated concentrations of both parent and metabolic parabens...
August 13, 2018: Environmental Science & Technology
Ill-Min Chung, Kaliyaperumal Rekha, Govindasamy Rajakumar, Muthu Thiruvengadam
Glucosinolates (GSLs) and phenolic compounds (PCs) are biologically active and involved in the defense reaction of plants; these compounds have a beneficial effect on human health. In this study, we described the influence of biologically synthesized silver nanoparticles (Ag NPs) to enhance the phytochemicals (GSLs and PCs), their transcription levels, and their biological activities in genetically transformed root cultures (hairy root cultures) of Brassica rapa. The concentrations of silver and reactive oxygen species (malondialdehyde and hydrogen peroxide) were highly elevated in the Ag NP-elicited hairy roots (HRs)...
July 28, 2018: Bioprocess and Biosystems Engineering
Alba C Mayta-Apaza, Ellen Pottgen, Jana De Bodt, Nora Papp, Daya Marasini, Luke Howard, Laszlo Abranko, Tom Van de Wiele, Sun-Ok Lee, Franck Carbonero
Tart cherries have been reported to exert potential health benefits attributed to their specific and abundant polyphenol content. However, there is a need to study the impact and fate of tart cherries polyphenols in the gut microbiota. Here, tart cherries, pure polyphenols (and apricots) were submitted to in vitro bacterial fermentation assays and assessed through 16S rRNA gene sequence sequencing and metabolomics. A short-term (5 days, 8 oz. daily) human dietary intervention study was also conducted for microbiota analyses...
April 7, 2018: Journal of Nutritional Biochemistry
Xin Chen, Hongzhi Tang, Yongdi Liu, Ping Xu, Yong Xue, Kuangfei Lin, Changzheng Cui
3-Hydroxybenzoate 6-hydroxylase, an NADH-dependent flavoprotein, can convert 3-hydroxybenzoate which is an important intermediate in the biodegradation of many aromatic hydrocarbons. 3-Hydroxybenzoate is metabolized by entering the TCA cycle through the gentisate pathway. We found a putative 3HB6H gene from a cluster that potentially encodes for gentisic acid degradation from a halophilic Martelella sp. strain AD-3. The corresponding protein was expressed with an N -terminal His-tag and purified by Ni2+ -nitrilotriacetic acid affinity chromatography...
2018: Frontiers in Microbiology
Saiadali Fathima K, Sathiyendran M, Anitha K
The molecular complexes of 2-amino-1H-benzimidazolium 2-hydroxybenzoate (2ABHB) and 2-amino-1H-benzimidazolium pyridine 2-carboxylate (2ABP2C) were synthesised from a donor 2-aminobenzimidazole (2AB), and acceptors, 2-hydroxybenzoate (2HB) and pyridine 2-carboxylic acid (P2C) respectively. The brown colour single crystals were successfully grown by slow evaporation solution growth technique. The densities of grown crystals 2ABHB and 2ABP2C were measured by floatation method using carbon tetrachloride and xylene as solvents...
October 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
Henry Syukur Purwanto, Mi-Sook Kang, Lenny Ferrer, Sang-Soo Han, Jin-Young Lee, Hak-Sung Kim, Jin-Ho Lee
4-Hydroxybenzoate (4HBA) is a valuable platform intermediate for the production of commodity and fine chemicals, including protocatechuate, cis,cis-muconic acid, adipic acid, terephthalic acid, phenol, vanillin, and 4-hydroxybenzyl alcohol glycoside (gastrodin). Here we describe rational engineering of the shikimate and related pathways in Corynebacterium glutamicum ATCC13032 for over-producing 4HBA. As an approach to increase the carbon flux to 4HBA, we first introduced a mutated chorismate-pyruvate lyase (CPLpr ) and feedback-resistant 3-deoxy-d-arabinoheptulosonate-7-phosphate synthases encoded by ubiCpr and aroFfbr /aroGfbr , respectively, from Escherichia coli along with blockage of carbon flux to the biosynthetic pathways for aromatic amino acids and the catabolic pathway for 4HBA by deletion of the genes trpE (encoding anthranilate synthase I), csm (chorismate mutase), and pobA (4HBA hydroxylase)...
July 19, 2018: Journal of Biotechnology
Madan Kumar, Anjali Singhal, Praveen Kumar Verma, Indu Shekhar Thakur
The present study investigates polyhydroxyalkanoate (PHA) production from lignin and its derivatives by a previously reported lignin-degrading bacterial strain Pandoraea sp. ISTKB. PHA production was screened by fluorescence microscopy and flow cytometry using a Nile red stain. PHA and biomass accumulation, while screening, was found to be maximum on 4-hydroxybenzoic acid followed by p -coumaric acid, vanillic acid, 2,6-dimethoxyphenol, and kraft lignin after 96 h. Monomer composition was analyzed by gas chromatography-mass spectrometry (GC-MS) and was followed by Fourier transform infrared and 1 H NMR analysis, indicating PHA to be a copolymer of P(hydroxybutyrate- co -hydroxyvalerate)...
December 31, 2017: ACS Omega
Ferdinando Bruno, Suann Errico, Simona Pace, Maxim B Nawrozkij, Arthur S Mkrtchyan, Francesca Guida, Rosa Maisto, Abdurrahman Olgaç, Michele D'Amico, Sabatino Maione, Mario De Rosa, Erden Banoglu, Oliver Werz, Antonio Fiorentino, Rosanna Filosa
The release of pro-inflammatory mediators, such as prostaglandines (PGs) and leukotrienes (LTs), arising from the arachidonic acid (AA) cascade, play a crucial role in initiating, maintaining, and regulating inflammatory processes. New dual inhibitors of 5-lipoxygenase (5-LO) and microsomal prostaglandin E2 synthase-1 (mPGES-1), that block, at the same time, the formation of PGE2 and LTs, are currently emerged as a highly interesting drug candidates for better pharmacotherapie of inflammation-related disorders...
July 15, 2018: European Journal of Medicinal Chemistry
Ying Han, Li-Ming Xu, Cui-Yun Nie, Shuo Jiang, Jing Sun, Chao-Guo Yan
The pillar[5]arene mono- and di(oxyalkoxy)benzoic acids were successfully prepared in high yields by sequential alkylation of ω-bromoalkoxy-substituted pillar[5]arenes with methyl or ethyl p -hydroxybenzoate followed by a hydrolytic reaction under basic conditions. Under catalysis of HOBt/EDCl, the amidation reaction of pillar[5]arene mono(oxybutoxy)benzoic acid with monoamido-functionalized pillar[5]arenes afforded diamido-bridged bis-pillar[5]arenes. 1 H NMR and 2D NOESY spectra clearly indicated that [1]rotaxanes were formed by insertion of longer diaminoalkylene unit into the cavity of one pillar[5]arene with another pillar[5]arene acting as a stopper...
2018: Beilstein Journal of Organic Chemistry
Xue-Qiang Cao, Jia-Yuan Wang, Lian Zhou, Bo Chen, Yu Jin, Ya-Wen He
Xanthomonadins are yellow pigments that are produced by the phytopathogen Xanthomonas campestris pv. campestris (Xcc). A pig cluster is responsible for xanthomonadin biosynthesis. Previously, Xcc4014 of the cluster was characterized as a bifunctional chorismatase that produces 3-hydroxybenzoic acid (3-HBA) and 4-HBA. In this study, genetic analysis identified 11 genes within the pig cluster to be essential for xanthomonadin biosynthesis. Biochemical and bioinformatics analysis suggest that xanthomonadins are synthesized via an unusual type II polyketide synthase pathway...
July 11, 2018: Molecular Microbiology
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