keyword
https://read.qxmd.com/read/38491477/o-glcnacylation-a-pro-survival-response-to-acute-stress-in-the-cardiovascular-and-central-nervous-systems
#21
REVIEW
Qiu Xue, Shengtao Ji, Hui Xu, Shu Yu
O-GlcNAcylation is a unique monosaccharide modification that is ubiquitously present in numerous nucleoplasmic and mitochondrial proteins. The hexosamine biosynthesis pathway (HBP), which is a key branch of glycolysis, provides the unique sugar donor UDP-GlcNAc for the O-GlcNAc modification. Thus, HBP/O-GlcNAcylation can act as a nutrient sensor to perceive changes in nutrient levels and trigger O-GlcNAc modifications of functional proteins in cellular (patho-)physiology, thereby regulating diverse metabolic processes...
March 16, 2024: European Journal of Medical Research
https://read.qxmd.com/read/38488834/lessons-and-untapped-potential-of-smartphone-based-physical-activity-interventions-for-mental-health-narrative-review
#22
REVIEW
Emily E Bernstein, Emma C Wolfe, Brynn M Huguenel, Sabine Wilhelm
BACKGROUND: Physical activity has well-known and broad health benefits, including antidepressive and anxiolytic effects. However, only approximately half of Americans meet even the minimum exercise recommendations. Individuals with anxiety, depression, or related conditions are even less likely to do so. With the advent of mobile sensors and phones, experts have quickly noted the utility of technology for the enhanced measurement of and intervention for physical activity. In addition to being more accessible than in-person approaches, technology-driven interventions may uniquely engage key mechanisms of behavior change such as self-awareness...
March 15, 2024: JMIR MHealth and UHealth
https://read.qxmd.com/read/38484296/morphgi-a-self-propelling-soft-robotic-endoscope-through-morphing-shape
#23
JOURNAL ARTICLE
Julius E Bernth, Guokai Zhang, Dionysios Malas, George Abrahams, Bu Hayee, Hongbin Liu
Colonoscopy is currently the best method for detecting bowel cancer, but fundamental design and construction have not changed significantly in decades. Conventional colonoscope (CC) is difficult to maneuver and can lead to pain with a risk of damaging the bowel due to its rigidity. We present the MorphGI, a robotic endoscope system that is self-propelling and made of soft material, thus easy to operate and inherently safe to patient. After verifying kinematic control of the distal bending segment, the system was evaluated in: a benchtop colon simulator, using multiple colon configurations; a colon simulator with force sensors; and surgically removed pig colon tissue...
March 14, 2024: Soft Robotics
https://read.qxmd.com/read/38479306/ultrasensitive-and-label-free-electrochemical-immunosensor-for-the-detection-of-the-ovarian-cancer-biomarker-ca125-based-on-cuco-onss-aunps-nanocomposites
#24
JOURNAL ARTICLE
Wendi Mu, Chunyan Wu, Fangfang Wu, Hongmin Gao, Xinshui Ren, Jing Feng, Meng Miao, Hehua Zhang, Dong Chang, Hongzhi Pan
Cancer antigen 125 (CA125) is pivotal as a tumor marker in early ovarian cancer prevention and diagnosis. In this work, we introduced an ultrasensitive label-free electrochemical immunosensor tailored for CA125 detection, leveraging nanogold-functionalized copper-cobalt oxide nanosheets (CuCo-ONSs@AuNPs) as nanocomposites. For the inaugural application, copper-cobalt oxide nanosheets delivered the requisite DPV electrochemical response for the immunosensors. Their large specific surface area and commendable electrical conductivity amplify electron transfer and enable significant gold nanoparticle loading...
March 5, 2024: Journal of Pharmaceutical and Biomedical Analysis
https://read.qxmd.com/read/38479111/organelle-adaptations-in-response-to-mechanical-forces-during-tumour-dissemination
#25
REVIEW
Vittoria Graziani, Eva Crosas-Molist, Samantha L George, Victoria Sanz-Moreno
Cell migration plays a pivotal role in various biological processes including cancer dissemination and successful metastasis, where the role of mechanical signals is increasingly acknowledged. This review focuses on the intricate mechanisms through which cancer cells modulate their migratory strategies via organelle adaptations in response to the extracellular matrix (ECM). Specifically, the nucleus and mitochondria emerge as pivotal mediators in this process. These organelles serve as sensors, translating mechanical stimuli into rapid metabolic alterations that sustain cell migration...
March 12, 2024: Current Opinion in Cell Biology
https://read.qxmd.com/read/38478991/flexible-arranged-biomimetic-array-integrated-with-parallel-entropy-driven-circuits-for-ultrasensitive-multiple-and-reliable-detection-of-cancer-related-micrornas
#26
JOURNAL ARTICLE
Ziyi Tian, Chuyan Zhang, Mengfan Wu, Jie Luo, Huiling Zhou, Yixiang Duan, Yongxin Li
With the emergence of microRNA (miRNA) as a promising biomarker in cancer diagnosis, it is significant to develop multiple analyses of miRNAs. However, it still faces difficulties in ensuring the sensitivity and accuracy during multiplex detection owing to the low abundance and experimental deviation of miRNAs. In this work, a flexible-arranged biomimetic array integrated with parallel entropy-driven circuits (EDCs) was developed for ultrasensitive, multiplex, reliable, and high-throughput detection of miRNAs...
March 13, 2024: ACS Sensors
https://read.qxmd.com/read/38475720/tracing-vitamins-on-the-long-non-coding-lane-of-the-transcriptome-vitamin-regulation-of-lncrnas
#27
REVIEW
Fatemeh Yazarlou, Fatemeh Alizadeh, Leonard Lipovich, Roberta Giordo, Soudeh Ghafouri-Fard
A major revelation of genome-scale biological studies in the post-genomic era has been that two-thirds of human genes do not encode proteins. The majority of non-coding RNA transcripts in humans are long non-coding RNA (lncRNA) molecules, non-protein-coding regulatory transcripts with sizes greater than 500 nucleotides. LncRNAs are involved in nearly every aspect of cellular physiology, playing fundamental regulatory roles both in normal cells and in disease. As result, they are functionally linked to multiple human diseases, from cancer to autoimmune, inflammatory, and neurological disorders...
March 12, 2024: Genes & Nutrition
https://read.qxmd.com/read/38475170/building-flexible-scalable-and-machine-learning-ready-multimodal-oncology-datasets
#28
JOURNAL ARTICLE
Aakash Tripathi, Asim Waqas, Kavya Venkatesan, Yasin Yilmaz, Ghulam Rasool
The advancements in data acquisition, storage, and processing techniques have resulted in the rapid growth of heterogeneous medical data. Integrating radiological scans, histopathology images, and molecular information with clinical data is essential for developing a holistic understanding of the disease and optimizing treatment. The need for integrating data from multiple sources is further pronounced in complex diseases such as cancer for enabling precision medicine and personalized treatments. This work proposes Multimodal Integration of Oncology Data System (MINDS)-a flexible, scalable, and cost-effective metadata framework for efficiently fusing disparate data from public sources such as the Cancer Research Data Commons (CRDC) into an interconnected, patient-centric framework...
March 2, 2024: Sensors
https://read.qxmd.com/read/38475128/optical-sensor-system-for-3d-jones-matrix-reconstruction-of-optical-anisotropy-maps-of-self-assembled-polycrystalline-soft-matter-films
#29
JOURNAL ARTICLE
Waldemar Wójcik, Zhengbing Hu, Yuriy Ushenko, Andrzej Smolarz, Iryna Soltys, Oleksander Dubolazov, Oleksander Ushenko, Olexandra Litvinenko, Ivan Mikirin, Ivan Gordey, Oleksandr Pavlyukovich, Sergii Pavlov, Natalia Pavlyukovich, Saltanat Amirgaliyeva, Aliya Kalizhanova, Zhalau Aitkulov
Our work uses a polarization matrix formalism to analyze and algorithmically represent optical anisotropy by open dehydration of blood plasma films. Analytical relations for Jones matrix reconstruction of optical birefringence maps of protein crystal networks of dehydrated biofluid films are found. A technique for 3D step-by-step measurement of the distributions of the elements of the Jones matrix or Jones matrix images (JMI) of the optically birefringent structure of blood plasma films (BPF) has been created...
February 29, 2024: Sensors
https://read.qxmd.com/read/38475029/intelligent-flexible-artificial-throats-with-sound-emitting-detecting-and-recognizing-abilities
#30
REVIEW
Junxin Fu, Zhikang Deng, Chang Liu, Chuting Liu, Jinan Luo, Jingzhi Wu, Shiqi Peng, Lei Song, Xinyi Li, Minli Peng, Houfang Liu, Jianhua Zhou, Yancong Qiao
In recent years, there has been a notable rise in the number of patients afflicted with laryngeal diseases, including cancer, trauma, and other ailments leading to voice loss. Currently, the market is witnessing a pressing demand for medical and healthcare products designed to assist individuals with voice defects, prompting the invention of the artificial throat (AT). This user-friendly device eliminates the need for complex procedures like phonation reconstruction surgery. Therefore, in this review, we will initially give a careful introduction to the intelligent AT, which can act not only as a sound sensor but also as a thin-film sound emitter...
February 25, 2024: Sensors
https://read.qxmd.com/read/38474935/acceleration-of-hyperspectral-skin-cancer-image-classification-through-parallel-machine-learning-methods
#31
JOURNAL ARTICLE
Bernardo Petracchi, Emanuele Torti, Elisa Marenzi, Francesco Leporati
Hyperspectral imaging (HSI) has become a very compelling technique in different scientific areas; indeed, many researchers use it in the fields of remote sensing, agriculture, forensics, and medicine. In the latter, HSI plays a crucial role as a diagnostic support and for surgery guidance. However, the computational effort in elaborating hyperspectral data is not trivial. Furthermore, the demand for detecting diseases in a short time is undeniable. In this paper, we take up this challenge by parallelizing three machine-learning methods among those that are the most intensively used: Support Vector Machine (SVM), Random Forest (RF), and eXtreme Gradient Boosting (XGB) algorithms using the Compute Unified Device Architecture (CUDA) to accelerate the classification of hyperspectral skin cancer images...
February 21, 2024: Sensors
https://read.qxmd.com/read/38473033/use-of-sensor-array-analysis-to-detect-ovarian-cancer-through-breath-urine-and-blood-a-case-control-study
#32
JOURNAL ARTICLE
Roberto Angioli, Marco Santonico, Giorgio Pennazza, Roberto Montera, Daniela Luvero, Alessandra Gatti, Alessandro Zompanti, Panaiotis Finamore, Raffaele Antonelli Incalzi
Ovarian cancer (OC) is the eighth most common cancer in women. Since screening programs do not exist, it is often diagnosed in advanced stages. Today, the detection of OC is based on clinical examination, transvaginal ultrasound (US), and serum biomarker (Carbohydrate Antigen 125 (CA 125) and Human Epididymis Protein 4 (HE4)) dosage, with a sensitivity of 88% and 95%, respectively, and a specificity of 84% for US and 76% for biomarkers. These methods are clearly not enough, and OC in its early stages is often missed...
March 6, 2024: Diagnostics
https://read.qxmd.com/read/38472508/high-throughput-evaluation-of-genetic-variants-with-prime-editing-sensor-libraries
#33
JOURNAL ARTICLE
Samuel I Gould, Alexandra N Wuest, Kexin Dong, Grace A Johnson, Alvin Hsu, Varun K Narendra, Ondine Atwa, Stuart S Levine, David R Liu, Francisco J Sánchez Rivera
Tumor genomes often harbor a complex spectrum of single nucleotide alterations and chromosomal rearrangements that can perturb protein function. Prime editing has been applied to install and evaluate genetic variants, but previous approaches have been limited by the variable efficiency of prime editing guide RNAs. Here we present a high-throughput prime editing sensor strategy that couples prime editing guide RNAs with synthetic versions of their cognate target sites to quantitatively assess the functional impact of endogenous genetic variants...
March 12, 2024: Nature Biotechnology
https://read.qxmd.com/read/38464246/chlorpromazine-inhibits-eag1-channels-by-altering-the-coupling-between-the-pas-cnbh-and-pore-domains
#34
Mahdi Ghorbani, Ze-Jun Wang, Xi Chen, Purushottam B Tiwari, Jeffery B Klauda, Tinatin I Brelidze
EAG1 depolarization-activated potassium selective channels are important targets for treatment of cancer and neurological disorders. EAG1 channels are formed by a tetrameric subunit assembly with each subunit containing an N-terminal Per-Arnt-Sim (PAS) domain and C-terminal cyclic nucleotide-binding homology (CNBH) domain. The PAS and CNBH domains from adjacent subunits interact and form an intracellular tetrameric ring that regulates the EAG1 channel gating, including the movement of the voltage sensor domain (VSD) from closed to open states...
February 26, 2024: bioRxiv
https://read.qxmd.com/read/38462335/portable-photoelectrochemical-immunoassay-with-micro-electro-mechanical-system-for-alpha-fetoprotein-in-hepatocellular-carcinoma
#35
JOURNAL ARTICLE
Fangming Lou, Shaojie Wang, Bo Han, Qunfang Li, Dianping Tang
Early detection of cancer has a profound impact on patient survival and treatment outcomes considering high treatment success rates and reduced treatment complexity. Here, we developed a portable photoelectrochemical (PEC) immune platform for sensitive testing of alpha-fetoprotein (AFP) based on Pt nanocluster (Pt NCs) loaded defective-state g-C3 N4 photon-electron transducers. The broad forbidden band structure of g-C3 N4 was optimized by the nitrogen doping strategy and additional homogeneous porous structure was introduced to further enhance the photon utilization...
April 15, 2024: Analytica Chimica Acta
https://read.qxmd.com/read/38457862/development-of-a-point-of-care-colorimetric-metabolomic-sensor-platform
#36
JOURNAL ARTICLE
Songtian Bai, Pablo Gonzalez-Vasquez, Claudia Torres-Calzada, Scott MacKay, James Cook, Yeganeh Khaniani, Gareth Davies, Upasana Singh, Prashanthi Kovur, Jie Chen, David S Wishart
Metabolomics is the large-scale study of small molecule metabolites within a biological system. It has applications in measuring dietary intake, predicting heart disease risk, and diagnosing cancer. Metabolites are often measured using high-end analytical tools such as mass spectrometers or large spectrophotometers. However, due to their size, cost, and need for skilled operators, using such equipment at the bedside is not practical. To address this issue, we have developed a low-cost, portable, optical color sensor platform for metabolite detection...
March 4, 2024: Biosensors & Bioelectronics
https://read.qxmd.com/read/38457321/towards-a-wireless-image-sensor-for-real-time-fluorescence-microscopy-in-cancer-therapy
#37
JOURNAL ARTICLE
Rozhan Rabbani, Hossein Najafiaghdam, Micah Roschelle, Efthymios Philip Papageorgiou, Biqi Rebekah Zhao, Mohammad Meraj Ghanbari, Rikky Muller, Vladimir Stojanovic, Mekhail Anwar
We present a mm-sized, ultrasonically powered lensless CMOS image sensor as a progress towards wireless fluorescence microscopy. Access to biological information within the tissue has the potential to provide insights guiding diagnosis and treatment across numerous medical conditions including cancer therapy. This information, in conjunction with current clinical imaging techniques that have limitations in obtaining images continuously and lack wireless compatibility, can improve continual detection of multicell clusters deep within tissue...
March 8, 2024: IEEE Transactions on Biomedical Circuits and Systems
https://read.qxmd.com/read/38456635/self-feedback-dnazyme-motor-for-cascade-amplified-imaging-of-mrna-in-live-cells-and-in-vivo
#38
JOURNAL ARTICLE
Xiaohong Zhong, Jing Hua, Ming Shi, Yifang He, Yong Huang, Beilei Wang, Liangliang Zhang, Shulin Zhao, Li Hou, Hong Liang
DNA motors have attracted extensive interest in biosensing and bioimaging. However, the amplification capacity of the existing DNA motor systems is limited since the products from the walking process are unable to feedback into the original DNA motor systems. As a result, the sensitivities of such systems are limited in the contexts of biosensing and bioimaging. In this study, we report a novel self-feedback DNAzyme motor for the sensitive imaging of tumor-related mRNA in live cells and in vivo with cascade signal amplification capacity...
March 8, 2024: ACS Sensors
https://read.qxmd.com/read/38456344/identification-of-pancreatic-metastasis-cells-and-cell-spheroids-by-the-organelle-targeting-sensor-array
#39
JOURNAL ARTICLE
Guoyang Zhang, Zirui Wang, Lijun Ma, Jiguang Li, Jiahao Han, Mingguang Zhu, Zixuan Zhang, Shilong Zhang, Xin Zhang, Zhuo Wang
Pancreatic cancer is a highly malignant and metastatic cancer. Pancreatic cancer can lead to liver metastases, gallbladder metastases, and duodenum metastases. The identification of pancreatic cancer cells is essential for the diagnosis of metastatic cancer and exploration of carcinoma in situ. Organelles play an important role in maintaining the function of cells, the various cells show significant difference in organelle microenvironment. Herein, six probes were synthesized for targeting mitochondria, lysosomes, cell membranes, endoplasmic reticulum, Golgi apparatus, and lipid droplets...
March 8, 2024: Advanced Healthcare Materials
https://read.qxmd.com/read/38450702/live-cell-imaging-and-real-time-monitoring-of-nucleolus-morphology-and-mitophagy-with-a-red-fluorescent-and-photostable-rrna-specific-probe-in-human-cancer-cells
#40
JOURNAL ARTICLE
Jun-Ren Luo, Wei Long, Ze-Xin Chen, Shi-Min Wang, Yao-Xun Zeng, Yu-Jing Lu, Bo-Xin Zheng, Meng-Ting She, Wing-Leung Wong
rRNAs are prevalent in living organisms. They are produced in nucleolus and mitochondria and play essential cellular functions. In addition to the primary biofunction in protein synthesis, rRNAs have been recognized as the emerging signaling molecule and drug target for studies on nucleolus morphology, mitochondrial autophagy, and tumor cell malignancy. Currently, only a few rRNA-selective probes have been developed, and most of them encounter the drawbacks of low water solubility, poor nuclear membrane permeability, short emission wavelength, low stability against photobleaching, and high cytotoxicity...
March 7, 2024: ACS Sensors
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