keyword
MENU ▼
Read by QxMD icon Read
search

Crosslinking

keyword
https://www.readbyqxmd.com/read/29667656/carbon-based-hybrid-nanogels-a-synergistic-nanoplatform-for-combined-biosensing-bioimaging-and-responsive-drug-delivery
#1
REVIEW
Hui Wang, Qianwang Chen, Shuiqin Zhou
Nanosized crosslinked polymer networks, named as nanogels, are playing an increasingly important role in a diverse range of applications by virtue of their porous structures, large surface area, good biocompatibility and responsiveness to internal and/or external chemico-physical stimuli. Recently, a variety of carbon nanomaterials, such as carbon quantum dots, graphene/graphene oxide nanosheets, fullerenes, carbon nanotubes, and nanodiamonds, have been embedded into responsive polymer nanogels, in order to integrate the unique electro-optical properties of carbon nanomaterials with the merits of nanogels into a single hybrid nanogel system for improvement of their applications in nanomedicine...
April 18, 2018: Chemical Society Reviews
https://www.readbyqxmd.com/read/29666915/corneal-crosslinking-cxl-with-18-mw-cm-2-irradiance-and-5-4-j-cm-2-radiant-exposure-early-postoperative-safety
#2
Isaak Fischinger, Theo G Seiler, Karthiga Santhirasegaram, Moritz Pettenkofer, Chris P Lohmann, Daniel Zapp
PURPOSE: To investigate safety of accelerated corneal crosslinking during the first postoperative month. METHODS: In this retrospective study, 76 eyes of 60 patients with verified progressive keratectasia were enrolled in this study and followed for 1 month after accelerated CXL (18 mW/cm2 for 5 min, radiant exposure 5.4 J/cm2 ) (A-CXL(5*18)). Preoperatively, objective refraction, slit lamp inspection, and corneal tomography were performed. Early postoperative slit lamp examinations were performed on days 1 and 4...
April 17, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29666835/aptamers-and-apple-pies-a-mini-review-of-psma-aptamers-and-lessons-from-donald-s-coffey
#3
REVIEW
Shawn E Lupold
This mini-review article is part of a special issue dedicated to Donald S. Coffey, a pioneer translational research scientist, exemplary mentor, and leader in urologic and urologic oncology research. This article first briefly reflects on life and scientific lessons from Don Coffey. It then reviews the development of two prostate cancer targeting RNA aptamers, xPSM-A9 and xPSM-A10, through in vitro selection for aptamers that bind to the extracellular domain of the Prostate Specific Membrane Antigen (PSMA)...
2018: American Journal of Clinical and Experimental Urology
https://www.readbyqxmd.com/read/29666038/correlation-of-serum-ccl3-mip-1%C3%AE-levels-with-disease-severity-in-postmenopausal-osteoporotic-females
#4
Hui Wan, Tie-Yong Qian, Xiao-Jing Hu, Ci-You Huang, Wei-Feng Yao
BACKGROUND: The pro-inflammatory protein chemokine cytokine ligand 3 is well-established as a vital regulator of bone resorption and osteoclasts stimulation. AIMS: We sought to investigate if serum chemokine cytokine ligand 3 levels correlated with disease severity in postmenopausal osteoporosis females. STUDY DESIGN: Cross-sectional Study. METHODS: 82 postmenopausal osteoporotic females, 76 postmenopausal non-osteoporotic women and 80 healthy female at childbearing age were recruited...
April 15, 2018: Balkan Medical Journal
https://www.readbyqxmd.com/read/29665386/enzymatically-crosslinked-and-mechanically-tunable-silk-fibroin-pullulan-hydrogels-for-mesenchymal-stem-cells-delivery
#5
Tao Li, Xiongbo Song, Changmei Weng, Xin Wang, Jiangyi Wu, Li Sun, Xiaoyuan Gong, Wei-Nan Zeng, Liu Yang, Cheng Chen
Hydrogels with good biocompatibility, proper degradation rates, and tissue-matched elasticity are widely used in tissue engineering, regenerative medicine, and drug delivery. In this study, enzymatically crosslinked biocompatible hydrogels were successfully developed using silk fibroin (SF) and pullulan (PL) under physiological conditions in the presence of both horseradish peroxidase (HRP) and hydrogen peroxide (H2 O2 ). A series of properties of the hydrogels including gelation time, equilibrium swelling, enzyme degradation, morphology, rheological property, and compression modulus of SF/PL hydrogels were studied by varying the concentration of PL...
April 14, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29665227/microenvironment-induced-pim-kinases-promote-cxcr4-triggered-mtor-pathway-required-for-chronic-lymphocytic-leukaemia-cell-migration
#6
Emilia Białopiotrowicz, Patryk Górniak, Monika Noyszewska-Kania, Bartosz Puła, Hanna Makuch-Łasica, Grażyna Nowak, Aleksandra Bluszcz, Maciej Szydłowski, Ewa Jabłonska, Karolina Piechna, Tomasz Sewastianik, Anna Polak, Ewa Lech-Marańda, Bożena K Budziszewska, Maja Wasylecka-Juszczyńska, Katarzyna Borg, Krzysztof Warzocha, Wojciech Czardybon, Michał Gałęzowski, Renata Windak, Krzysztof Brzózka, Przemysław Juszczyński
Lymph node microenvironment provides chronic lymphocytic leukaemia (CLL) cells with signals promoting their survival and granting resistance to chemotherapeutics. CLL cells overexpress PIM kinases, which regulate apoptosis, cell cycle and migration. We demonstrate that BCR crosslinking, CD40 stimulation, and coculture with stromal cells increases PIMs expression in CLL cells, indicating microenvironment-dependent PIMs regulation. PIM1 and PIM2 expression at diagnosis was higher in patients with advanced disease (Binet C vs...
April 17, 2018: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29664953/combined-experimental-and-computational-characterization-of-crosslinked-collagen-based-hydrogels
#7
Clara Valero, Hippolyte Amaveda, Mario Mora, Jose Manuel García-Aznar
Collagen hydrogels are widely used for in-vitro experiments and tissue engineering applications. Their use has been extended due to their biocompatibility with cells and their capacity to mimic biological tissues; nevertheless their mechanical properties are not always optimal for these purposes. Hydrogels are formed by a network of polymer filaments embedded on an aqueous substrate and their mechanical properties are mainly defined by the filament network architecture and the individual filament properties...
2018: PloS One
https://www.readbyqxmd.com/read/29664217/kidney-decellularized-extracellular-matrix-hydrogels-rheological-characterization-and-human-glomerular-endothelial-cell-response-to-encapsulation
#8
Jimmy Su, Simon C Satchell, Ramille N Shah, Jason A Wertheim
Hydrogels, highly-hydrated crosslinked polymer networks, closely mimic the microenvironment of native extracellular matrix (ECM) and thus present as ideal platforms for three-dimensional cell culture. Hydrogels derived from tissue- and organ-specific decellularized ECM (dECM) may retain bioactive signaling cues from the native tissue or organ that could in turn modulate cell-material interactions and response. In this study, we demonstrate that porcine kidney dECM can be processed to form hydrogels suitable for cell culture and encapsulation studies...
April 17, 2018: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29663706/patient-specific-bioinks-for-3d-bioprinting-of-tissue-engineering-scaffolds
#9
Negar Faramarzi, Iman K Yazdi, Mahboubeh Nabavinia, Andrea Gemma, Adele Fanelli, Andrea Caizzone, Leon M Ptaszek, Indranil Sinha, Ali Khademhosseini, Jeremy N Ruskin, Ali Tamayol
Bioprinting has emerged as a promising tool in tissue engineering and regenerative medicine. Various 3D printing strategies have been developed to enable bioprinting of various biopolymers and hydrogels. However, the incorporation of biological factors has not been well explored. As the importance of personalized medicine is becoming more clear, the need for the development of bioinks containing autologous/patient-specific biological factors for tissue engineering applications becomes more evident. Platelet-rich plasma (PRP) is used as a patient-specific source of autologous growth factors that can be easily incorporated to hydrogels and printed into 3D constructs...
April 16, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29663702/assembly-of-peg-microgels-into-porous-cell-instructive-3d-scaffolds-via-thiol-ene-click-chemistry
#10
Shangjing Xin, Omar M Wyman, Daniel L Alge
The assembly of microgel building blocks into 3D scaffolds is an emerging strategy for tissue engineering. A key advantage is that the inherent microporosity of these scaffolds provides cells with a more permissive environment than conventional nanoporous hydrogels. Here, norbornene-bearing poly(ethylene glycol) (PEG) based microgels are assembled into 3D cell-instructive scaffolds using a PEG-dithiol linker and thiol-ene click photopolymerization. The bulk modulus of these materials depends primarily on the crosslink density of the microgel building blocks...
April 16, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29663426/comparison-of-blue-and-white-lamp-light-with-sunlight-for-daylight-mediated-5-ala-photodynamic-therapy-in-vivo
#11
Kayla Marra, Ethan P LaRochelle, M Shane Chapman, P Jack Hoopes, Karina Lukovits, Edward V Maytin, Tayyaba Hasan, Brian W Pogue
Daylight-mediated photodynamic therapy (d-PDT) as a treatment for actinic keratosis (AK) is an increasingly common technique due to a significant reduction in pain, leading to better patient tolerability. While past studies have looked at different light sources and delivery methods, this study strives to provide equivalent PpIX-weighted light doses with the hypothesis that artificial light sources could be equally as effective as natural sunlight if their PpIX-weighted fluences were equalized. Normal mouse skin was used as the model to compare blue LED light, metal halide white light, and natural sunlight, with minimal incubation time between topical ALA application and the onset of light delivery...
April 16, 2018: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/29663380/transglutaminase-activity-regulates-differentiation-migration-and-fusion-of-osteoclasts-via-affecting-actin-dynamics
#12
Huifang Sun, Mari T Kaartinen
Osteoclasts, bone resorbing cells, derive from monocyte/macrophage cell lineage. Increased osteoclast activity is responsible for bone destruction in diseases such as osteoporosis, periodontitis and rheumatoid arthritis. Transglutaminases (TGs), protein crosslinking enzymes, were recently found involved in osteoclastogenesis in vivo, however their mechanisms of action have remained unknown. In this study, we have investigated the role of TG activity in osteoclastogenesis in vitro using four TG inhibitors, NC9, Z006, T101, and monodansyl cadaverine...
April 16, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29663002/-patterning-with-loops-to-dynamically-reconfigure-polymer-gels
#13
Santidan Biswas, Victor V Yashin, Anna C Balazs
The structural and mechanical properties of gels can be controlled by promoting the unfolding (and refolding) of loops (stored lengths) embedded within the networks. As a loop unfolds, the released chain length can increase the extensibility and reconfigurability of the gel. Here, we develop a theoretical model that couples the elasticity of the gel to the dynamic transitions occurring in loops that lie between the crosslinks. Using this model, we show that a thermally-induced swelling of the gel generates an internal strain, which unfolds the loops and thereby further increases the degree of gel swelling...
April 17, 2018: Soft Matter
https://www.readbyqxmd.com/read/29662977/handheld-skin-printer-in-situ-formation-of-planar-biomaterials-and-tissues
#14
Navid Hakimi, Richard Cheng, Lian Leng, Mohammad Sotoudehfar, Phoenix Qing Ba, Nazihah Bakhtyar, Saeid Amini-Nik, Marc G Jeschke, Axel Günther
We present a handheld skin printer that enables the in situ formation of biomaterial and skin tissue sheets of different homogeneous and architected compositions. When manually positioned above a target surface, the compact instrument (weight <0.8 kg) conformally deposits a biomaterial or tissue sheet from a microfluidic cartridge. Consistent sheet formation is achieved by coordinating the flow rates at which bioink and cross-linker solution are delivered, with the speed at which a pair of rollers actively translate the cartridge along the surface...
April 17, 2018: Lab on a Chip
https://www.readbyqxmd.com/read/29661755/a-cd123-targeting-antibody-drug-conjugate-imgn632-designed-to-eradicate-aml-while-sparing-normal-bone-marrow-cells
#15
Yelena Kovtun, Gregory E Jones, Sharlene Adams, Lauren Harvey, Charlene A Audette, Alan Wilhelm, Chen Bai, Lingyun Rui, Rassol Laleau, Fenghua Liu, Olga Ab, Yulius Setiady, Nicholas C Yoder, Victor S Goldmacher, Ravi V J Chari, Jan Pinkas, Thomas Chittenden
The outlook for patients with refractory/relapsed acute myeloid leukemia (AML) remains poor, with conventional chemotherapeutic treatments often associated with unacceptable toxicities, including severe infections due to profound myelosuppression. Thus there exists an urgent need for more effective agents to treat AML that confer high therapeutic indices and favorable tolerability profiles. Because of its high expression on leukemic blast and stem cells compared with normal hematopoietic stem cells and progenitors, CD123 has emerged as a rational candidate for molecularly targeted therapeutic approaches in this disease...
April 24, 2018: Blood Advances
https://www.readbyqxmd.com/read/29661312/development-and-characterisation-of-hybrid-polysaccharide-membranes-for-dehydration-processes
#16
Inês T Meireles, Rosa M Huertas, Cristiana A V Torres, Isabel M Coelhoso, João G Crespo
The purpose of this work is the development and characterisation of new hybrid polysaccharide (FucoPol) membranes. These membranes were prepared by incorporation of a SiO2 network homogeneously dispersed by using a sol-gel method with GPTMS as a crosslinker silica precursor. They were further crosslinked with CaCl2 for reinforcement of mechanical properties and improvement of their permeation performance. They were characterised in terms of their structural, mechanical and thermal properties. They presented a dense and homogeneous structure, resistant to deformation, with a Tg of 43 °C and a thermal decomposition between 240 and 251 °C...
July 1, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29661308/excellent-reusable-chitosan-cellulose-aerogel-as-an-oil-and-organic-solvent-absorbent
#17
Zhanying Li, Lin Shao, Wenbin Hu, Tingting Zheng, Lingbin Lu, Yang Cao, Yongjun Chen
Absorption is one of the most important methods for oil spill cleanup. An ideal absorbent is expected to possess advantages of low cost, green, high absorption capacity and excellent reusability. In this paper, a new kind of cellulose aerogel was successfully fabricated via cellulose oxidation, crosslinking, freeze drying and cold plasma modification. The obtained aerogel (water contact angle up to 152.8°) exhibited outstanding oil/water selectivity and high absorption capacity (13.77-28.20 g/g) for various oils and organic solvents...
July 1, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29661303/super-water-absorbing-polymeric-gel-from-chitosan-citric-acid-and-urea-synthesis-and-mechanism-of-water-absorption
#18
Abathodharanan Narayanan, Ravishankar Kartik, Elanchezhian Sangeetha, Raghavachari Dhamodharan
A new superabsorbent with maximum water absorption capacity of ∼1250 g/g is prepared by hydrothermal synthesis from sustainable and biodegradable resources such as chitosan, citric acid and urea (denoted as 'CHCAUR'). CHCAUR is characterized extensively by various analytical techniques such as PXRD, SSNMR, FTIR, and TGA. Pure and saline water absorption study showed that CHCAUR could be a better adsorbent compared to the super absorbent polymer (SAP) used in commercial diaper material. The mechanism of water absorption is shown to arise out of a combination of electrostatic attraction of water to the ionic crosslinks and the presence of macropores as well as undulated surface due to the formation of nanofibrous bundles...
July 1, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29660925/influence-of-different-surface-treatments-of-poly-n-butyl-acrylate-networks-on-fibroblasts-adhesion-morphology-and-viability
#19
A Krüger-Genge, S Braune, M Walter, M Krengel, K Kratz, J H Küpper, A Lendlein, F Jung
BACKGROUND: Physical and chemical characteristics of implant materials determine the fate of long-term cardiovascular devices. However, there is still a lack of fundamental understanding of the molecular mechanisms occurring in the material-tissue interphase. In a previous study, soft covalently crosslinked poly(n-butyl acrylate) networks (cPnBA) were introduced as sterilizable, non-toxic and immuno-compatible biomaterials with mechanical properties adjustable to blood vessels. Here we study the influence of different surface treatments in particular oxygen plasma modification and fibrinogen deposition as well as a combinatorial approach on the adhesion and viability of fibroblasts...
April 7, 2018: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/29660797/repair-of-a-giant-omphalocele-in-an-infant-with-a-pericardial-implant-crosslinked-with-oligourethane
#20
Juan Vargas-Mancilla, María A Torrero-Serrato, Aarón J Palacios-Rodríguez, Gloria B Rodríguez-de León, Metzeri I Montes-Rodríguez, Birzabith Mendoza-Novelo
The giant omphalocele (GO) represents a challenge for the pediatric surgeon in its management and wall abdominoplasty. Here, we report the outcome of a case in which a GO in a newborn patient was repaired with an implant derived from decellularized bovine pericardium crosslinked with oligourethane. The implantation time was extended for 6 months. This was then followed up by the retrieval of the implant and the subsequent reconstruction in a second surgical time by the closure of the abdominal wall fascia...
April 16, 2018: Artificial Organs
keyword
keyword
16589
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"