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Phil A Hart, Dana K Andersen, Kieren J Mather, Alicia C Castonguay, Mandeep Bajaj, Melena D Bellin, David Bradley, Noemy Contreras, Aida Habtezion, Murray Korc, Yogish Kudva, Maxim S Petrov, David C Whitcomb, Dhiraj Yadav, Ying Yuan, Jo Ann S Rinaudo, Sudhir Srivastava, Jose Serrano, Mark O Goodarzi
Pancreatogenic diabetes mellitus is most commonly the result of chronic pancreatitis but can also occur secondary to pancreatic cancer. The early identification of pancreatogenic diabetes and distinction from the more prevalent type 2 diabetes are clinically significant; however, currently, there is no validated method to differentiate these diabetes subtypes. We describe a study, "Evaluation of a Mixed Meal Test for Diagnosis and Characterization of PancrEaTogEniC DiabeTes Secondary to Pancreatic Cancer and Chronic Pancreatitis: the DETECT study," that seeks to address this knowledge gap...
November 2018: Pancreas
Dhiraj Yadav, Walter G Park, Evan L Fogel, Liang Li, Suresh T Chari, Ziding Feng, William E Fisher, Christopher E Forsmark, Christie Y Jeon, Aida Habtezion, Phil A Hart, Steven J Hughes, Mohamed O Othman, Jo Ann S Rinaudo, Stephen J Pandol, Temel Tirkes, Jose Serrano, Sudhir Srivastava, Stephen K Van Den Eeden, David C Whitcomb, Mark Topazian, Darwin L Conwell
Prospective Evaluation of Chronic Pancreatitis for Epidemiologic and Translational Studies (PROCEED) is the first prospective, observational cohort study of chronic pancreatitis (CP) in the United States. The primary goals of PROCEED are to define disease progression, test the predictive capability of candidate biomarkers, and develop a platform to conduct translational and mechanistic studies in CP. Using objective and consensus-driven criteria, PROCEED will enroll adults at different stages of CP-controls, suspected CP, and definite CP...
November 2018: Pancreas
William E Fisher, Zobeida Cruz-Monserrate, Amy L McElhany, Gregory B Lesinski, Phil A Hart, Ria Ghosh, George Van Buren, Douglas S Fishman, Jo Ann S Rinaudo, Jose Serrano, Sudhir Srivastava, Thomas Mace, Mark Topazian, Ziding Feng, Dhiraj Yadav, Stephen J Pandol, Steven J Hughes, Robert Y Liu, Emily Lu, Robert Orr, David C Whitcomb, Amer S Abouhamze, Hanno Steen, Zachary M Sellers, David M Troendle, Aliye Uc, Mark E Lowe, Darwin L Conwell
High-quality and well-annotated biorepositories are needed to better understand the pathophysiology and biologic mechanisms of chronic pancreatitis (CP) and its consequences. We report a methodology for the development of a robust standard operating procedure (SOP) for a biorepository based on the experience of the clinical centers within the consortium to study Chronic Pancreatitis, Diabetes and Pancreas Cancer Clinical Centers (CPDPC), supported by the National Cancer Institute and the National Institute for Diabetes and Digestive and Kidney Diseases as a unique multidisciplinary model to study CP, diabetes, and pancreatic cancer in both children and adults...
November 2018: Pancreas
Christopher E Forsmark, Dana K Andersen, John T Farrar, Megan Golden, Aida Habtezion, Sohail Z Husain, Liang Li, Julia Mayerle, Stephen J Pandol, Aliye Uc, Zixi Zhu, Dhiraj Yadav
The lack of effective therapeutic agents specifically tailored for chronic pancreatitis (CP) has hampered clinical care and negatively impacted patients' lives. New mechanistic insights now point to novel therapies, which involve both recently developed and/or repurposed agents. This working group focused on 2 main outcomes for CP: pain and progression of disease. The goal is to frame the essential aspects of trial design including patient-centered outcomes, proposed methods to measure the outcomes of pain and progression, and study design considerations for future trials to facilitate rapid drug development for patients with CP...
November 2018: Pancreas
Temel Tirkes, Zarine K Shah, Naoki Takahashi, Joseph R Grajo, Stephanie T Chang, Sudhakar K Venkatesh, Darwin L Conwell, Evan L Fogel, Walter Park, Mark Topazian, Dhiraj Yadav, Anil K Dasyam
Chronic pancreatitis is an inflammatory condition of the pancreas with clinical manifestations ranging from abdominal pain, acute pancreatitis, exocrine and/or endocrine dysfunction, and pancreatic cancer. There is a need for longitudinal studies in well-phenotyped patients to ascertain the utility of cross-sectional imaging findings of chronic pancreatitis for diagnosis and assessment of disease severity. CT and MR cholangiopancreatography are the most common cross-sectional imaging studies performed for the evaluation of chronic pancreatitis...
October 16, 2018: Radiology
Poonam Parashar, Chandra Bhushan Tripathi, Malti Arya, Jovita Kanoujia, Mahendra Singh, Abhishek Yadav, Amit Kumar, Anupam Guleria, Shubhini A Saraf
Co-therapy through biotin modified nanoparticles (NPs) of gefitinib (Gnb) and naringenin (Nar) was investigated for its therapeutic and synergistic potential against lung cancer. The biotin-conjugated polymeric NPs (bty-Nar/Gnb) were developed using oil in water emulsion technique and optimized using central composite design. The formulations were subjected to various in vitro (A549 cell lines) and in vivo evaluations in urethane-induced lung cancer. Co-administration of Gnb and Nar NPs displayed a significant reduction in tumour volume while restoring the biochemical parameters and serum metabolites to normal levels...
October 16, 2018: Artificial Cells, Nanomedicine, and Biotechnology
Kaustubh Ahuja, Bhavuk Garg, Buddhadev Chowdhuri, Raj Kumar Yadav, Pradeep Kumar Chaturvedi
Study Design: Single-center, observational, case-control study. Purpose: Comparison and analysis of the metabolic and coagulative profiles in patients with idiopathic scoliosis, patients with congenital scoliosis, and healthy controls. Overview of Literature: Serum melatonin deficiency has been a controversial topic in the etiopathogenesis of scoliosis. Low bone mineral density, low vitamin D3 levels, and high parathyroid hormone levels are common metabolic abnormalities associated with scoliosis that may be responsible for its pathogenesis...
October 16, 2018: Asian Spine Journal
Sumit Kumar Jain, Mohammad Yahya Dar, Sanjeev Kumar, Arun Yadav, Stephen R Kearns
BACKGROUND: Post-operative pain may adversely affect a patient's quality of life. Studies have shown that vitamin C, being an anti-oxidant and neuro-modulating agent, can help to reduce pain in a variety of clinical settings. The objective of this randomized controlled trial was to assess the effectiveness of vitamin C in reducing post-operative pain, analgesia requirements and improving functional outcome. METHODS: Patients with isolated foot and ankle trauma, who had undergone surgery, were randomly assigned to receive either vitamin C 500mg or a placebo tablet twice a day...
May 24, 2018: Foot and Ankle Surgery: Official Journal of the European Society of Foot and Ankle Surgeons
B V Siva Prasad, Vishal Khatri, P Suresh Yadav, M Subhosh Chandra, D Vijaya Lakshmi, Kalyan Goswami
Background: After mass drug administration to eliminate human lymphatic filariasis, there is a need for surveillance to detect the measurable endpoint of the program. Methods: An immunodominant seroreactive clone, WbL1, was identified through immunoscreening of a Wuchereria bancrofti L3 complementary DNA expression library. Recombinant WbL1 (rWbL1) was analysed with sera from W. bancrofti patients. Diagnostic evaluation was carried out by developing an enzyme-linked immunosorbent assay (ELISA) to detect the filarial-specific antibodies in various categories of filarial sera samples against recombinant WbL1 (rWbL1) protein...
October 15, 2018: Transactions of the Royal Society of Tropical Medicine and Hygiene
Mange R Yadav, Mukesh Kumar, Prashant R Murumkar, Puja P Hazari, Anil K Mishra
Some quaternary gemini amphiphiles (GAs) were synthesized as nonviral gene delivery carriers. The critical miceller concentration values of these amphiphiles are indicative of their superior surface-active properties. All of the synthesized GAs, alone or along with lipids like cholesterol and/or dioleoylphosphatidyl ethanolamine (DOPE), were formulated as liposomes. Formulations of GAs with DOPE showed average particle diameters of 326-400 nm with positive ζ-potential (30.1-46.4 mV). The lipoplexes of theses formulations showed complete pDNA retention at the base at a N/P ratio higher than 1...
September 30, 2018: ACS Omega
Nasreen Bano, Manisha Yadav, Bhudev C Das
Aim: To investigate the role of a herbal antioxidative compound curcumin on cell proliferation, orosphere formation and miRNA-21 expression in HPV16+ve/-ve oral cancer stem cells. Materials and Methods: Oral cancer stem cells were isolated from HPV+ve/HPV-ve oral cancer cell lines by FACS and stemness markers. MTT, spheroid assay and qRT-PCR were employed to examine the effects of curcumin. Results: Curcumin treatment in micromolar concentration (0-50 μM) demonstrated significant differential inhibition in CSC proliferation, orosphere formation and miRNA-21 expression in a dose dependent manner, the effect being highly pronounced in HPV positive CSCs...
2018: Frontiers in Oncology
Meenakshi Chaswal, Raj Kapoor, Achla Batra, Savita Verma, Bhupendra S Yadav
Alterations in the autonomic cardiovascular control have been implicated to play an important etiologic role in preeclampsia. The present study was designed to evaluate autonomic functions in preeclamptic pregnant women and compare the values with normotensive pregnant and healthy nonpregnant controls. Assessment of autonomic functions was done by cardiovascular reflex tests and by analysis of heart rate variability (HRV). Cardiovascular reflex tests included deep breathing test (DBT) and lying to standing test (LST)...
2018: International Journal of Hypertension
Rajesh Kumar Kori, Manish Kumar Singh, Abhishek Kumar Jain, Rajesh Singh Yadav
The problem of pesticides is not new and its exposure to human due to indiscriminate use is largely associated with the health related problems including neurotoxicological alterations. High levels of pesticide residues and their metabolites in the dietary constituents, food materials, maternal blood, cord blood, placenta breast milk have been reported and linked to alterations in birth weight, crown heel length, head circumference, mid-arm circumference and ponderal index of the neonates. Epidemiological studies have suggested that exposure of pesticide to human could be a significant risk factor for neurological disorders, including Parkinson's disease, Alzheimer's disease and multiple sclerosis...
October 2018: Indian Journal of Clinical Biochemistry: IJCB
Chandravati Yadav, Pradip K Maji
This study investigates the synergistic potential of natural bio-extracts for preparing "all-natural" composite bio-sponges of sodium alginate (SA) with the reinforcement of a natural bio-nanomaterial i.e., cellulose nanofibres (CNFs). Aqueous suspensions of SA and CNFs in various combinations of bio-extracts (Rice water (Rw) and Giloy extract (Ge)) were freeze-dried to obtain the composite bio-sponges. Composites prepared using Rw resulted in structurally more stable samples with porosity above 75% that showed a compact honeycomb-like microstructure with interlocked CNFs network structures...
January 1, 2019: Carbohydrate Polymers
Jayakumar Sreenivasan, Muhammad Shahzeb Khan, Heyi Li, Min Zhuo, Axi Patel, Setri Fugar, Morgan Tarbutton, Sisir Siddamsetti, Neha Yadav
BACKGROUND: Role of statins in prevention of contrast-induced acute kidney injury (CI-AKI) in patients undergoing coronary angiography remains controversial. We studied the use of statins in decreasing CI-AKI following coronary angiography. METHODS: We reviewed all patients who underwent coronary angiography with or without PCI and had a follow-up creatinine from January 2012 to December 2016 at a single tertiary care center in the United States. CI-AKI was defined as 0...
September 15, 2018: Cardiovascular Revascularization Medicine: Including Molecular Interventions
Jay Prakash, Sunita Yadav, Gundappa Saha, Adarsh Kumar Chiranjivi, Suresh Kumar, Santanu Sasidharan, Prakash Saudagar, Vikash Kumar Dubey
Trypanothione based redox metabolism is unique to the Trypanosomatida family. Despite extensive studies on redox metabolism of Leishmania parasites, a prominent question of why Leishmania adopt this unique redox pathway remains elusive. We have episomally expressed human glutathione reductase (HuGR) in Leishmania donovani (LdGR+) and investigated its effect. LdGR+ strain has slower growth compared to the wild type (Ld) indicating decreased survival ability of the strain. Further, LdGR+ strain showed enhanced accumulation of intracellular reactive oxygen species (ROS) and more sensitivity to the anti-leishmanial drug, Miltefosine, inferring increased stress level...
October 11, 2018: International Journal of Biological Macromolecules
Radha Yadav, Debpriyo Kumar Dey, Rishika Vij, Sunita Meena, Rajeev Kapila, Suman Kapila
Interest in probiotics has grown significantly in the last decades due to their reported nutritional and health promoting effects. The aim of this study is to investigate the therapeutic potential of probiotic fermented milk (PFM) prepared using three different probiotic strains i.e. Lactobacillus rhamnosus MTCC: 5957, Lactobacillus rhamnosus MTCC: 5897 and Lactobacillus fermentum MTCC: 5898; independently or in combination, for treating streptozotocin induced type-1 diabetes in male Wistar rats. Diabetic rats were fed with PFM preparations for 6 weeks and then analyzed for the various biochemical parameters associated...
October 10, 2018: Microbial Pathogenesis
Sunil Kumar Yadav, Ella Maria Kadas, Seyedamirhosein Motamedi, Konrad Polthier, Frank Haußer, Kay Gawlik, Friedemann Paul, Alexander Brandt
We present a method for optic nerve head (ONH) 3-D shape analysis from retinal optical coherence tomography (OCT). The possibility to noninvasively acquire in vivo high-resolution 3-D volumes of the ONH using spectral domain OCT drives the need to develop tools that quantify the shape of this structure and extract information for clinical applications. The presented method automatically generates a 3-D ONH model and then allows the computation of several 3-D parameters describing the ONH. The method starts with a high-resolution OCT volume scan as input...
October 2018: Journal of Biomedical Optics
Arjun Desai, Mrinalini A Yadav, Viney Gupta, Shikha Gupta
A 15-year-old male patient presented with vision loss after blunt trauma to the right eye and with clinical evidence of posterior lenticonus. The posttraumatic lenticonus was eccentric (superotemporal). Irregular astigmatism with high myopia on dilated retinoscopy within the lenticonus, localized posterior convexity of peripheral capsule on ultrasound biomicroscopy, and increased higher-order aberrations (HOAs) on wavefront aberrometry compared with fellow-eye findings confirmed the diagnosis. To our knowledge, acquired peripheral posterior lenticonus representing dialysis of Weigert ligament after acute blunt trauma is a new finding...
October 9, 2018: Journal of Cataract and Refractive Surgery
Kathleen M Adelgais, Matthew Hansen, Brooke Lerner, J Joelle Donofrio, Kabir Yadav, Kathleen Brown, Yiju T Liu, Paula Denslow, Kurt Denninghoff, Paul Ishimine, Lenora M Olson
The evidence supporting best practices when treating children in the prehospital setting or even the effect Emergency Medical Services (EMS) has on patient outcomes is limited. Standardizing the critical outcomes for EMS research will allow for focused and comparable effort among the small but growing group of pediatric EMS investigators on specific topics. Standardized outcomes will also provide the opportunity to collectively advance the science of EMS for children and demonstrate the effect of EMS on patient outcomes...
October 12, 2018: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
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