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Bibek Banskota, Prakash Yadav, Tarun Rajbhandari, O P Shrestha, Divya Talwar, Ashok Banskota, David A Spiegel
BACKGROUND: To our knowledge, there are no reports of the Ponseti method initiated after walking age and with >10 years of follow-up. Our goal was to report the clinical findings and patient-reported outcomes for children with a previously untreated idiopathic clubfoot who were seen when they were between 1 and 5 years old, were treated with the Ponseti method, and had a minimum follow-up of 10 years. METHODS: A retrospective review of medical records was supplemented by a follow-up evaluation of physical findings (alignment and range of motion) and patient-reported outcomes using the Oxford Ankle Foot Questionnaire for Children (OxAFQ-C)...
December 5, 2018: Journal of Bone and Joint Surgery. American Volume
Rachit K Saxena, Abhishek Rathore, Abhishek Bohra, Pooja Yadav, Roma Rani Das, Aamir W Khan, Vikas K Singh, Annapurna Chitikineni, Indra P Singh, C V Sameer Kumar, K B Saxena, Rajeev K Varshney
As one of the major outputs of next-generation sequencing (NGS), a large number of genome-wide single-nucleotide polymorphisms (SNPs) have been developed in pigeonpea [ (L.) Huth.]. However, SNPs require a genotyping platform or assay to be used in different evolutionary studies or in crop improvement programs. Therefore, we developed an Axiom SNP array with 56K SNPs uniformly distributed across the genome and assessed its utility in a genetic diversity study. From the whole-genome resequencing (WGRS) data on 104 pigeonpea lines, ∼2 million sequence variations (SNPs and insertion-deletions [InDels]) were identified, from which a subset of 56,512 unique and informative sequence variations were selected to develop the array...
November 2018: Plant Genome
Sonu Yadav, Adam J Stow, Rebecca M B Harris, Rachael Y Dudaniec
Invertebrate pests often show high morphological variation and wide environmental tolerances. Knowledge of how phenotypic variation is associated with environmental heterogeneity can elucidate the processes underpinning these patterns. Here we examine morphological variation and relative abundance along environmental gradients in a widespread agricultural pest, native to Australia, the wingless grasshopper Phaulacridium vittatum (Sjöstedt). We test for correlations between body size, wing presence, and stripe polymorphism with environmental variables...
November 1, 2018: Journal of Insect Science
Mazda K Turel, Manjul Tripathi, Ashish Aggarwal, Navneet Singla, Chirag K Ahuja, Aastha Takkar, Sahil Mehta, Kanwaljeet Garg, Ravi Yadav, Anant Mehrotra, Kuntal K Das
No abstract text is available yet for this article.
November 2018: Neurology India
Shailendra Ratre, Nishtha Yadav, Vijay Singh Parihar, Amitesh Dubey, Yad Ram Yadav
Introduction: Although there are controversies about the optimal management of spontaneous intracerebral hemorrhage (ICH), benefits of endoscopic procedures in ICH have been reported. This study is aimed to evaluate the result of 270 patients undergoing endoscopic treatment of ICH. Methods: This was a retrospective study from July 2008 to June 2017. All procedures were done with the endoscopic technique using a tubular retractor. Patients with the hematoma volume between 30 to 80 ml, with the Glasgow Coma Scale (GCS) between 5 to 14, and evidence of severe mass effect, were included in the study...
November 2018: Neurology India
Ravi Yadav, Saketh Kapoor, Mayank Madhukar, Rajini M Naduthota, Arun Kumar, Pramod Kumar Pal
Background: Mutations in the glucocerebrosidase (GBA) gene have been associated with Parkinson's disease (PD). Several variants in the gene have been identified as risk factors for the development of PD, but there is difference in the prevalence of this mutation in various ethnic groups and countries. There is no published study related to this field on the Indian population. Aims and Objectives: The aim of the study was to investigate the frequency of mutations in the GBA gene in Indian patients with PD...
November 2018: Neurology India
José A Fernández Robledo, Raghavendra Yadavalli, Bassem Allam, Emmanuelle Pales-Espinosa, Marco Gerdol, Samuele Greco, Rebecca J Stevick, Marta Gómez-Chiarri, Ying Zhang, Cynthia A Heil, Adrienne N Tracy, David Bishop-Bailey, Michael J Metzger
Bivalves, from raw oysters to steamed clams, are popular choices among seafood lovers and once limited to the coastal areas. The rapid growth of the aquaculture industry and improvement in the preservation and transport of seafood have enabled them to be readily available anywhere in the world. Over the years, oysters, mussels, scallops, and clams have been the focus of research for improving the production, managing resources, and investigating basic biological and ecological questions. During this decade, an impressive amount of information using high-throughput genomic, transcriptomic and proteomic technologies has been produced in various classes of the Mollusca group, and it is anticipated that basic and applied research will significantly benefit from this resource...
November 29, 2018: Developmental and Comparative Immunology
Binit Sureka, Kuldeep Yadav, Pawan Kumar Garg, Pushpinder Singh Khera
No abstract text is available yet for this article.
November 29, 2018: Abdominal Radiology
Anu Yadav, Vijay D Mendhulkar
Introduction: Cancer is one of the leading causes of mortality in the world and there are many types of cancer. The current treatments against cancer are surgery, chemotherapy, and radiation therapy, but these come with varied side effects as they harm noncancer cells too. Therefore, search for new treatments is one of the important research areas nowadays and nanoparticles are one such potential anticancer agent. Aim of the Study: We hypothesized that silver nanoparticles and tea extract may have anticancer activities along with their synergistic counterparts with adriamycin (ADR) on HT-29 human colon cancer cell line, MCF-7 human breast cancer cell line, and MOLT-4 human leukemia cancer cell line...
October 2018: Journal of Cancer Research and Therapeutics
Punita Lal, Vipul Nautiyal, Mranalini Verma, Rajan Yadav, K J Maria Das, Shaleen Kumar
Background: Parotid-sparing intensity-modulated radiotherapy (IMRT) effectively reduces xerostomia in head-and-neck cancer (HNC). Changes in the salivary output at 1 year were studied and correlation with quality of life (QOL) changes in patients of locally advanced HNC (LAHNC) was drawn. Materials and Methods: Between October 2009 and October 2011, 20 patients of LAHNC were treated with IMRT using simultaneous integrated boost technique. High-risk clinical target volume (CTV) was given a dose of 66 Gy/30 fr, intermediate-risk CTV 60 Gy/30 fr, and low-risk CTV 54 Gy/30 fr...
October 2018: Journal of Cancer Research and Therapeutics
Wei Ding, Daniel P Higgins, Dilip K Yadav, Adwait A Godbole, Read Pukkila-Worley, Amy K Walker
S-adenosylmethionine (SAM) is a donor which provides the methyl groups for histone or nucleic acid modification and phosphatidylcholine production. SAM is hypothesized to link metabolism and chromatin modification, however, its role in acute gene regulation is poorly understood. We recently found that Caenorhabditis elegans with reduced SAM had deficiencies in H3K4 trimethylation (H3K4me3) at pathogen-response genes, decreasing their expression and limiting pathogen resistance. We hypothesized that SAM may be generally required for stress-responsive transcription...
November 28, 2018: PLoS Genetics
Marialaura Dilillo, Erik L de Graaf, Avinash Yadav, Mikhail E Belov, Liam A McDonnell
The identification of molecular ions produced by MALDI or ESI strongly relies on their fragmentation to structurally informative fragments. The widely diffused fragmentation techniques for ESI multiply charged ions, are either incompatible (ECD and ETD) or show lower efficiency (CID, HCD), with the predominantly singly charged peptide and protein ions formed by MALDI. In source decay (ISD) has been successfully adopted to sequence MALDI generated ions, but it further increases spectral complexity and it is not compatible with Mass Spectrometry Imaging...
November 28, 2018: Journal of Proteome Research
Bipadabhanjan Mallick, Dibya J Shrama, Pradeep Siddappa, Narendra Dhaka, Sarthak Malik, Saroj K Sinha, Thakur D Yadav, Vikas Gupta, Rakesh Kochhar
Background and aim: Overall, a handful of studies are available on the outcomes of recurrent acute pancreatitis (RAP), in comparison to the first episode of acute pancreatitis (AP). We aimed to provide a more complete and updated picture of RAP and how it is different from the initial episode of AP. Methods: Consecutive patients admitted with an episode of AP over 8 years were divided into two groups on the basis of prior episodes: AP and RAP. Primary outcome measures were for surgical necrosectomy and mortality...
August 2018: JGH open: an open access journal of gastroenterology and hepatology
Saransh Jain, Saurabh Kedia, Sawan Bopanna, Dawesh P Yadav, Sandeep Goyal, Peush Sahni, Nihar R Dash, Sujoy Pal, Govind Makharia, Vineet Ahuja
Background and Aim: The extent of disease of ulcerative colitis (UC) has been found to be a predictor of acute severe colitis (ASC), but it is unclear whether the extent of disease at the index episode of ASC is a predictor of long-term outcome. Methods: Hospitalized patients satisfying Truelove and Witts' criteria under follow-up at a single center from January 2003 to December 2016 were included. The extent of disease at index ASC was classified according to the Montreal classification as left-sided or extensive colitis...
December 2017: JGH open: an open access journal of gastroenterology and hepatology
Maxim S Petrov, Dhiraj Yadav
Knowledge of pancreatitis in the 20th century was shaped predominantly by animal data and clinical trials. Several large general population-based cohort studies and comprehensive systematic literature reviews in the 21st century have had a major effect on our understanding of pancreatitis and its sequelae. This Review provides precise and up-to-date data on the burden of acute pancreatitis, chronic pancreatitis and post-pancreatitis diabetes mellitus. Exocrine pancreatic insufficiency and altered bone metabolism following pancreatitis are also discussed...
November 27, 2018: Nature Reviews. Gastroenterology & Hepatology
Ashok Kumar Pathera, Charanjit Singh Riar, Sanjay Yadav, Pradeep Kumar Singh
Response surface methodology was used to study the effect of egg albumen (5-15 g), vegetable oil (5-15 g), and corn bran (5-15 g) on sensory and textural (firmness and toughness) quality of chicken nuggets cooked by the oven, steam, and microwave methods. The egg albumen and vegetable oil had a positive linear effect but corn bran had a negative linear effect at p<0.01 on sensory overall acceptability scores of nuggets. Firmness and toughness scores were increased significantly (p<0.01) with the increase in corn bran level in the formulation...
October 2018: Korean Journal for Food Science of Animal Resources
Rahul Pasupureddy, Atul Yadav, Sriram Seshadri, Veena Pande, Rajnikant Dixit, Kailash C Pandey
Despite several setbacks in the fight against malaria such as insecticide and drug resistance as well as low efficacy of available vaccines, considerable success in reducing malaria burden has been achieved in the past decade. Artemisinins (ARTs and their combination therapies, ACTs), the current frontline drugs against uncomplicated malaria, rapidly kill plasmodial parasites and are non-toxic at short exposures. Though the exact mode of action remains unclear, the endoperoxide bridge, indispensable for ART activity, is thought to react with heme released from hemoglobin hydrolysis and generate free radicals that alkylate multiple protein targets, thereby disrupting proteostasis pathways...
November 26, 2018: Parasitology Research
Muhammad Shahzeb Khan, Muhammad Shariq Usman, Tauseef Akhtar, Sajjad Raza, Salil Deo, Ankur Kalra, Muhammad Hassan Nasim, Neha Yadav, Deepak L Bhatt
Prognostic significance of coronary circulation dominance remains controversial. The primary objective of this meta-analysis was to pool all the available evidence to assess the influence of left coronary dominance (LD) on outcomes in patients who underwent percutaneous coronary intervention (PCI). MEDLINE, Cochrane CENTRAL, and Scopus databases were searched for all observational studies and randomized controlled trials that investigated the association between coronary dominance and outcomes in patients who underwent PCI...
December 15, 2018: American Journal of Cardiology
H K Aggarwal, Deepak Jain, Sudhir Mor, R K Yadav, Promil Jain
Introduction: Albuminuria is predictor of target organ damage and worse cardiovascular outcomes. Microalbuminuria has been found in a large number of patients with essential hypertension. Aim of our study was to evaluate the frequency of microalbuminuria in essential hypertension and to study its correlation with severity of hypertension and target organ damage. Materials and Methods: This cross-sectional study was conducted at the outpatient clinic of General Medicine department of Pt...
May 2018: Journal of the Association of Physicians of India
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