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Mohit Yadav, Jitendra Singh Rathore
Here we report the first essentially complete TAome analysis for type II toxin-antitoxin (TA) system, a major class of TA modules found in bacterial system, from entomopathogenic bacterium Xenorhabdus nematophila ATCC 19061 (NCBI RefSeq NC_014228). We summarize this analysis in terms of TA locus, accession identifier, hits in conserved domain database, toxin superfamily, antitoxin superfamily and chromosomal/mobile genome/plasmid occurrences. Moreover, for TA context analyses we use six different specifications namely virulence factors, mobile genetic elements (MGE), antibiotic resistance genes, secretion systems, prophage and a classification of mobile genetic elements (ACLAME); among these hits are found for only MGE, ACLAME and prophage...
July 11, 2018: Computational Biology and Chemistry
H K Aggarwal, Deepak Jain, Pulkit Chhabra, R K Yadav
No abstract text is available yet for this article.
July 1, 2018: Prilozi (Makedonska Akademija Na Naukite i Umetnostite. Oddelenie za Medicinski Nauki)
Johanna Kondelin, Kari Salokas, Lilli Saarinen, Kristian Ovaska, Heli Rauanheimo, Roosa-Maria Plaketti, Jiri Hamberg, Xiaonan Liu, Leena Yadav, Alexandra E Gylfe, Tatiana Cajuso, Ulrika A Hänninen, Kimmo Palin, Heikki Ristolainen, Riku Katainen, Eevi Kaasinen, Tomas Tanskanen, Mervi Aavikko, Minna Taipale, Jussi Taipale, Laura Renkonen-Sinisalo, Anna Lepistö, Selja Koskensalo, Jan Böhm, Jukka-Pekka Mecklin, Halit Ongen, Emmanouil T Dermitzakis, Outi Kilpivaara, Pia Vahteristo, Mikko Turunen, Sampsa Hautaniemi, Sari Tuupanen, Auli Karhu, Niko Välimäki, Markku Varjosalo, Esa Pitkänen, Lauri A Aaltonen
Microsatellite instability (MSI) leads to accumulation of an excessive number of mutations in the genome, mostly small insertions and deletions. MSI colorectal cancers (CRCs), however, also contain more point mutations than microsatellite-stable (MSS) tumors, yet they have not been as comprehensively studied. To identify candidate driver genes affected by point mutations in MSI CRC, we ranked genes based on mutation significance while correcting for replication timing and gene expression utilizing an algorithm, MutSigCV Somatic point mutation data from the exome kit-targeted area from 24 exome-sequenced sporadic MSI CRCs and respective normals, and 12 whole-genome-sequenced sporadic MSI CRCs and respective normals were utilized...
August 14, 2018: EMBO Molecular Medicine
S Yadav, Ioannis Eleftherianos
The Drosophila imaginal disc growth factors (IDGFs) induce the proliferation of imaginal disc cells and terminate cell proliferation at the end of larval development. However, the participation of Idgf encoding genes in other physiological processes of Drosophila including the immune response to infection is not fully understood. Here we show the contribution of Idgf2 and Idgf3 in the Drosophila response to infection with Steinernema carpocapsae nematodes carrying or lacking their mutualistic Xenorhabdus nematophila bacteria (symbiotic or axenic nematodes, respectively)...
August 14, 2018: Parasite Immunology
Debesh Bhoi, Velmurugan Selvam, Preeti Yadav, Praveen Talawar
No abstract text is available yet for this article.
April 2018: Journal of Anaesthesiology, Clinical Pharmacology
Srishti Munjal, Smriti R Deka, Santosh Yadav, Preeti Goyal, Ashwani K Sharma, Pradeep Kumar
Small molecule-based amphiphiles self-assemble into nanostructures (micelles) in aqueous medium which are currently being explored as novel drug delivery systems. Here, naproxen-polyethylene glycol (N-PEG), a small molecule-derived amphiphile, has been synthesised, characterised and evaluated as hydrophobic drug carrier. 1 H, 13 C Nuclear magnetic resonance (NMR), mass spectrometry (MS) and Fourier-transform infrared spectroscopy (FTIR) confirmed the formation of N-PEG and dynamic light scattering (DLS) revealed the formation of nano-sized structures of ∼228 nm...
September 2018: IET Nanobiotechnology
Deepika Singh, Vikas Kumar, Ekta Yadav, Neha Falls, Manvendra Singh, Ujendra Komal, Amita Verma
Facile green synthesis of silver nanoparticles (AgNPs) using an aqueous extract of Carissa carandas ( C. carandas ) leaves was studied. Fabrication of AgNPs was confirmed by the UV-visible spectroscopy which gives absorption maxima at 420 nm. C. carandas leaves are the rich source of the bioactive molecules, acts as a reducing and stabilising agent in AgNPs, confirmed by Fourier transforms infrared spectroscopy. The field emission scanning electron microscope revealed the spherical shape of biosynthesised AgNPs...
September 2018: IET Nanobiotechnology
Anju Manuja, Balvinder Kumar, Rajender Kumar, Meenu Chopra, Neeraj Dilbaghi, Sandeep Kumar, Suresh C Yadav
Quinapyramine sulfate (QS) produces trypanocidal effect against the parasite Trypanosoma evansi , but often poorly tolerated and causes serious local reactions in animals. The encapsulation of QS in chitosan/mannitol to provide the sustained release would improve both the therapeutic effect of QS and the quality of life of animals treated with this formulation. QS was encapsulated into nanoformulation prepared from chitosan, tripolyphosphate and mannitol nanomatrix (ChQS-NPs). ChQS-NPs were well-ordered in shape with nanoparticle size as determined by transmission electron microscopy and atomic force microscopy...
August 13, 2018: Antimicrobial Agents and Chemotherapy
Vanessa E Rees, Rajbharan Yadav, Kate E Rogers, Jürgen B Bulitta, Veronika Wirth, Antonio Oliver, John D Boyce, Anton Y Peleg, Roger L Nation, Cornelia B Landersdorfer
Hypermutable Pseudomonas aeruginosa are prevalent in chronic respiratory infections and have been associated with reduced lung function in cystic fibrosis (CF); these isolates can become resistant to all antibiotics in monotherapy. This study aimed to evaluate the time-course of bacterial killing and resistance of meropenem and ciprofloxacin in combination against hypermutable and non-hypermutable P. aeruginosa Static concentration time-kill experiments over 72h assessed meropenem and ciprofloxacin in mono- and combination therapy against PAO1 (non-hypermutable), PAOΔ mutS (hypermutable), and hypermutable isolates CW08, CW35 and CW44 obtained from CF patients with chronic respiratory infections...
August 13, 2018: Antimicrobial Agents and Chemotherapy
Dharmendra Singh, Chandan Kumar Singh, Yash Pal Singh, Vijayata Singh, Rajendra Singh, Ram Sewak Singh Tomar, Satish Kumar Sanwal, Sourabh Karwa, Vinay Kumar Mishra, Susheel Kumar Sarkar, Madan Pal, Arun Kumar, Rajendra Kumar Yadav, Parbodh Chander Sharma
In this study, 285 lentil genotypes were phenotyped under hydroponic and alkaline field conditions. Significant genotypic variation for alkalinity stress was observed among the six Lens species screened hydroponically and in the field having pH up to 9.1. The crucial parameters, like whole Na+ and K+ contents and the Na+/K+ ratio at 40 mM NaHCO3 were found significantly correlated with seedling survivability under hydroponics (r = -0.95, r = 0.93 and -0.97). Genotypes, ranked on the bases of seed yield, restricted uptake of Na+ with thick pith area, increased vascular bundles, less H2O2 production and low Na+/K+ ratio, were found important physio-anatomical traits for alkalinity stress tolerance...
2018: PloS One
Kunal Yadav, David M Vock, Arthur J Matas, William N Robiner, Thomas E Nevins
Background: Nonadherence to posttransplant immunosuppressive medication is associated with increased rates of rejection and graft loss, yet it is unknown to what degree ideal adherence is associated with the sequelae of overimmunosuppression. Specifically, we questioned whether excellent adherence increased the posttransplant cancer risk. Methods: Between August 1998 and August 2006, 195 consenting kidney transplant recipients had electronic monitoring of theirimmunosuppressive medication adherence...
August 8, 2018: Nephrology, Dialysis, Transplantation
Ritesh Sachdev, Shalini Goel, Neha Rastogi, Satya Prakash Yadav, Ishani Mohapatra
No abstract text is available yet for this article.
August 13, 2018: Acta Oncologica
Julia B Greer, Phil Greer, Bimaljit S Sandhu, Samer Alkaade, C Mel Wilcox, Michelle A Anderson, Stuart Sherman, Timothy B Gardner, Michele D Lewis, Nalini M Guda, Thiruvengadam Muniraj, Darwin Conwell, Gregory A Cote, Christopher E Forsmark, Peter A Banks, Gong Tang, Kim Stello, Andres Gelrud, Randall E Brand, Adam Slivka, David C Whitcomb, Dhiraj Yadav
BACKGROUND: Chronic pancreatitis (CP) patients frequently experience malabsorption and maldigestion, leading to micronutrient and macronutrient deficiencies. Comorbid diabetes and lifestyle habits, such as alcohol consumption, may impact nutrition status. METHODS: We compared micronutrient antioxidant, bone metabolism, serum protein, and inflammatory marker levels in 301 CP patients and 266 controls with no known pancreatic disease. We analyzed serum prealbumin and retinol binding protein; vitamins A, D, E, and B12; osteocalcin; tumor necrosis factor-α; and C-reactive protein (CRP)...
August 13, 2018: Nutrition in Clinical Practice
Umesh D Wankhade, Ji-Hyeon Lee, Pradeep K Dagur, Hariom Yadav, Michael Shen, Weiping Chen, Ashok B Kulkarni, J Philip McCoy, Toren Finkel, Aaron M Cypess, Sushil G Rane
OBJECTIVE: Beige/brite adipose tissue displays morphological characteristics and beneficial metabolic traits of brown adipose tissue. Previously, we showed that TGF-β signaling regulates the browning of white adipose tissue. Here, we inquired whether TGF-β signals regulated presumptive beige progenitors in white fat and investigated the TGF-β regulated mechanisms involved in beige adipogenesis. METHODS: We deleted TGF-β receptor 1 (TβRI) in adipose tissue (TβRIAdKO mice) and, using flow-cytometry based assays, identified and isolated presumptive beige progenitors located in the stromal vascular cells of white fat...
July 27, 2018: Molecular Metabolism
Vybhav Venkatesh, Rakesh Kumar, Dinesh Kumar Varma, Prateek Bhatia, Jaivinder Yadav, Devi Dayal
BACKGROUND: There is limited data on platelet alterations in children with type 1 diabetes mellitus (T1DM). We planned to study the effect of glycemic control and duration of T1DM on platelet morphology in children with T1DM. METHODS: We conducted an observational study on 260 children; 130 with T1DM (cases) and 130 healthy controls, in a tertiary care pediatric hospital. Platelet indices including Platelet count (PLT), Mean Platelet Volume (MPV), Platelet Distribution Width (PDW), Platelet-Large cell ratio (P-LCR), Plateletcrit (PCT) were measured, and their means were compared between cases and controls and various subgroups among the cases...
September 2018: Journal of Diabetes and its Complications
Vidya Sagar Reddy, Brijesh Yadav, Chhote Lal Yadav, Mukul Anand, Dilip Kumar Swain, Devendra Kumar, Deepika Kritania, Arun Kumar Madan, Jitender Kumar, Sarvajeet Yadav
Cryopreservation results in substantial deterioration of heat shock protein 70 (HSP70) and ultra-structural changes in sperm organelles, resulting in a marked reduction in post-thaw semen quality. The present study was aimed to explicate the effect of sericin supplementation on expression profile of HSP70, redox status and post-thaw semen quality in Barbari goat. Five Barbari bucks were used to collect thirty semen ejaculates by using artificial vagina and each ejaculate was divided into three aliquots to which sericin was supplemented at 0% (Control), 0...
August 9, 2018: Cryobiology
Vivek Kumar Yadav, Pradeep Kumar Singh, Manmohit Kalia, Deepmala Sharma, Sunil Kumar Singh, Vishnu Agarwal
Pseudomonas aeruginosa, an opportunistic pathogen release N-3-oxo-dodecanoyl-l-homoserine lactone (3-oxo-C12 HSL) and N-butyryl-l-homoserine lactone (C4 -HSL) quorum sensing (QS) molecules to regulate various virulence factors responsible for infection in the host. 3-oxo-C12 HSL not only regulates the bacterial gene expression but also modulates the host cell system. Thus, it is pertinent to evaluate the effect of these QS molecules on blood platelets which is responsible for the maintenance of hemostasis and thrombus formation...
July 30, 2018: International Journal of Medical Microbiology: IJMM
Bechien U Wu, Michael Batech, Elizabeth Y Dong, Lewei Duan, Dhiraj Yadav, Wansu Chen
BACKGROUND AND AIMS: To evaluate impact of ambulatory triglyceride levels on risk of recurrent pancreatitis in patients with hypertriglyceridemic pancreatitis. METHODS: We conducted a longitudinal retrospective cohort study of patients with serum triglyceride level ≥ 500 mg/dL during index hospitalization for acute pancreatitis within a regional integrated healthcare system between 2006 and 2013 (follow-up through 2015). Cases were identified based on combination of diagnosis codes and serum amylase/lipase...
August 9, 2018: Digestive Diseases and Sciences
Sarika Gunjan, Tanuj Sharma, Kanchan Yadav, Bhavana S Chauhan, Sunil K Singh, Mohammad I Siddiqi, Renu Tripathi
Although over the last 15 years, prevalence of malaria became reduced by over half but developing resistance against artemisinin derivatives and its combinations, which are only ray of hope to treat resistant malaria set back the control efforts and the key hinderence to achieve the goal of malaria elimination till 2030. In spite these artemisinins are precious antimalarials, their action mechanism is yet to be fully understood. Reactive oxygen species (ROS) produces by cleavage of endoperoxide bridge of artemisinin derivatives are known to be its antimalarial efficacy...
2018: Frontiers in Cellular and Infection Microbiology
Srinivas Bojanapu, Anand Nagar, Siddharth Mehrotra, Vivek Mangla, Shailendra Lalwani, Amitabh Yadav, Naimish Mehta, Samiran Nundy
Diverting loop ileostomy is a frequently done procedure accompanying colorectal surgeries. Dreaded complication is anastomotic leak. Early identification of anastomotic leak and apt management is required for better outcomes. Most often leak presents with fever, abdominal pain, rigidity, fever and hemodynamic instability. We report a rare occurrence of penoscrotal oedema in a patient with anastomotic leak and spontaneously subsiding with drainage of leaked contents.
August 2018: Journal of Surgical Case Reports
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