Amineh Sadat Tajani, Zeinab Amiri Tehranizadeh, Arianoosh Pourmohammad, Armin Pourmohammad, Milad Iranshahi, Faegheh Farhadi, Vahid Soheili, Bibi Sedigheh Fazly Bazzaz
OBJECTIVES: Biofilm-associated infections are challenging to manage or treat since the biofilm matrix is impenetrable to most antibiotics. Therefore, the best approach to deal with biofilm infections is to interrupt the construction during the initial levels. Biofilm formation has been regulated through the quorum sensing (QS) network, making it an attractive target for any antibacterial therapy. MATERIALS AND METHODS: Here, some coumarin members, including umbelliprenin, 4-farnesyloxycoumarin, gummosin, samarcandin, farnesifrol A, B, C, and auraptan, have been assessed as QS inhibitors in silico and in vitro...
April 2023: Iranian Journal of Basic Medical Sciences