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Particulate Matter Cancer

Gudrun Weinmayr, Marie Pedersen, Massimo Stafoggia, Zorana J Andersen, Claudia Galassi, Jule Munkenast, Andrea Jaensch, Bente Oftedal, Norun H Krog, Geir Aamodt, Andrei Pyko, Göran Pershagen, Michal Korek, Ulf De Faire, Nancy L Pedersen, Claes-Göran Östenson, Debora Rizzuto, Mette Sørensen, Anne Tjønneland, Bas Bueno-de-Mesquita, Roel Vermeulen, Marloes Eeftens, Hans Concin, Alois Lang, Meng Wang, Ming-Yi Tsai, Fulvio Ricceri, Carlotta Sacerdote, Andrea Ranzi, Giulia Cesaroni, Francesco Forastiere, Kees de Hoogh, Rob Beelen, Paolo Vineis, Ingeborg Kooter, Ranjeet Sokhi, Bert Brunekreef, Gerard Hoek, Ole Raaschou-Nielsen, Gabriele Nagel
INTRODUCTION: Previous analysis from the large European multicentre ESCAPE study showed an association of ambient particulate matter <2.5 μm (PM2.5 ) air pollution exposure at residence with the incidence of gastric cancer. It is unclear which components of PM are most relevant for gastric and also upper aerodigestive tract (UADT) cancer and some of them may not be strongly correlated with PM mass. We evaluated the association between long-term exposure to elemental components of PM2...
August 7, 2018: Environment International
Ruijin Li, Lifang Zhao, Li Zhang, Minghui Chen, Jing Shi, Chuan Dong, Zongwei Cai
Ambient fine particulate matter (PM2.5 ) is a complex mixture associated with lung cancer risk. PM2.5 -bound nitro-polycyclic aromatic hydrocarbons (NPAHs) have been demonstrated to possess mutagenicity and carcinogenicity. Previous studies showed that PM2.5 induced DNA damage, whereas there is little knowledge of whether 9-nitroanthracene (9-NA), a typical compound of NPAHs in PM2.5 , causes DNA damage. Also, the regulating mechanisms of PM2.5 and 9-NA in DNA damage and repair are not yet fully established...
September 1, 2017: Toxicology Research
Joshua K Kibet, Bornes C Mosonik, Vincent O Nyamori, Silas M Ngari
BACKGROUND: The atmosphere has become a major transport corridor for free radicals and particulate matter from combustion events. The motivation behind this study was to determine the nature of particulate emissions and surface bound radicals formed during the thermal degradation of diesel blends in order to assess the health and environmental hazards of binary transport fuels. METHODOLOGY: Accordingly, this contribution explored the interactions that occur when Croton megalocarpus biodiesel and fossil diesel in the ratio of 1:1 by weight were co-pyrolyzed in a quartz reactor at a residence time of 0...
August 7, 2018: Chemistry Central Journal
Zhiguo Cao, Leicheng Zhao, Xuejie Meng, Xiaotu Liu, Peipei Wu, Xinyi Fan, Shihua Wang, Jianye Jie, Zheng Miao, Xiaopeng Xu, Mohai Shen, Qingwei Bu
The health impact of haze is of great concern; however, few air quality studies have investigated trace pollutant contamination in the air. Size-segregated atmospheric particles (nine size fractions derived from PM10 ) were collected in dwelling (indoor) and traffic (outdoor) environments in Xinxiang, China, during light pollution conditions (air quality index (AQI), 60-90) and heavy pollution conditions (AQI, 350-550), and they were analysed for halogenated flame retardants (HFRs), including polybrominated diphenyl ethers (PBDEs), novel brominated flame retardants (NBFRs) and Dechlorane Plus (DP) isomers...
August 2, 2018: Journal of Hazardous Materials
Morteza Seifi, Sadegh Niazi, Graham Johnson, Vahideh Nodehi, Masud Yunesian
The relationship between air pollution and childhood cancer is inconclusive. We investigated the associations between exposure to ambient air pollution and childhood cancers in Tehran, Iran. This project included children between 1 and 15 years-of-age with a cancer diagnosis by the Center for the Control of Non Communicable Disease (n = 161) during 2007 to 2009. Controls were selected randomly within the city using a Geographic Information System (GIS) (n = 761). The cases were geocoded based on exact home addresses...
July 24, 2018: Science of the Total Environment
Changwoo Han, Soontae Kim, Youn-Hee Lim, Hyun-Joo Bae, Yun-Chul Hong
Background: We aimed to evaluate the spatial and temporal trends of the health burden attributable to particulate matter less than 2.5 µm in diameter (PM2.5 ) in the metropolitan cities and provinces of the Korea. Methods: We used modeled PM2.5 concentration data for the basic administrative levels, comprising the cities and the provinces of Korea, the corresponding annual population census data for each level, and the age and cause specific mortality data. We applied cause-specific integrated exposure-response functions to calculate the premature mortality attributable to ambient PM2...
July 23, 2018: Journal of Korean Medical Science
Chiou-Jye Huang, Ping-Huan Kuo
In modern society, air pollution is an important topic as this pollution exerts a critically bad influence on human health and the environment. Among air pollutants, Particulate Matter (PM2.5 ) consists of suspended particles with a diameter equal to or less than 2.5 &mu;m. Sources of PM2.5 can be coal-fired power generation, smoke, or dusts. These suspended particles in the air can damage the respiratory and cardiovascular systems of the human body, which may further lead to other diseases such as asthma, lung cancer, or cardiovascular diseases...
July 10, 2018: Sensors
Eleonora Longhin, Marina Camatini, Audun Bersaas, Paride Mantecca, Steen Mollerup
Exposure to particulate matter (PM) has been related to the onset of adverse health effects including lung cancer, but the underlying molecular mechanisms are still under investigation. Epithelial-to-mesenchymal transition (EMT) is regarded as a crucial step in cancer progression. In a previous study, we reported EMT-related responses in the human bronchial epithelial cell line HBEC3-KT, exposed to Milan airborne winter PM2.5. We also found a strong modulation of SERPINB2, encoding for the PAI-2 protein and previously suggested to play an important role in cancer...
July 9, 2018: Archives of Toxicology
Almudena Espín-Pérez, Julian Krauskopf, Marc Chadeau-Hyam, Karin van Veldhoven, Fan Chung, Paul Cullinan, Jolanda Piepers, Marcel van Herwijnen, Nadine Kubesch, Glòria Carrasco-Turigas, Mark Nieuwenhuijsen, Paolo Vineis, Jos C S Kleinjans, Theo M C M de Kok
Diesel vehicle emissions are the major source of genotoxic compounds in ambient air from urban areas. These pollutants are linked to risks of cardiovascular diseases, lung cancer, respiratory infections and adverse neurological effects. Biological events associated with exposure to some air pollutants are widely unknown but applying omics techniques may help to identify the molecular processes that link exposure to disease risk. Most data on health risks are related to long-term exposure, so the aim of this study is to investigate the impact of short-term exposure (two hours) to air pollutants on the blood transcriptome and microRNA expression levels...
June 20, 2018: Environmental Pollution
Chia-Hua Lin, Chia-Hsiang Lai, Yen-Ping Peng, Pei-Chun Wu, Kuen-Yuan Chuang, Ting-Yu Yen, Yao-Kai Xiang
The study investigated the exposure of spray painters to organic solvents, toxic metals, and hexavalent chromium over 21 working days in 2017. The results found these concentrations of 12 VOCs to be below the short-term exposure limit (STEL) established by the US Occupational Safety and Health Administration (OSHA). The mass concentration of total particulate matter (PM) exposure to workers was 20.01 ± 10.78 mg/m3 , which exceeds OSHA's permissible exposure level of 15 mg/m3 . The mean concentration of the total metals for all particle sizes was 109...
July 4, 2018: Environmental Science and Pollution Research International
Hongyan Lin, Xiaohong Zhang, Nannan Feng, Ruoyang Wang, Weituo Zhang, Xiaobei Deng, Yu Wang, Xiao Yu, Xiaofei Ye, Lei Li, Ying Qian, Herbert Yu, Biyun Qian
BACKGROUND/AIMS: Ecological studies have shown that air pollution and prevalence of cigarette smoking are positively correlated. Evidence also suggests a synergistic effect of cigarette smoking and PM2.5 exposure (Environmental Particulate Matter ≤ 2.5 µm in diameter) on lung cancer risk. We aimed to evaluate the interaction between smoking prevalence and PM2.5 pollution in relation to lung cancer mortality and determine its underlying mechanisms in vitro. METHODS: "MOVER" method was used to analyze the interaction between smoking prevalence and PM2...
2018: Cellular Physiology and Biochemistry
Paolo Vineis, Daniela Fecht
The proportion of total deaths attributable to environmental factors is estimated to be 23% of global deaths and 22% of global disability-adjusted life years (DALYs) according to one review. These estimates encompass all environmental agents including infectious agents but excluding behavioural factors. The authors of the review also estimated that 16% (95% CI: 7-41%) of cancer deaths are attributable to environmental risk factors (and 36% [95% CI: 17-52%] for lung cancer). In this article, we focus on the reasons why epidemiology is often unable to account for the whole burden of environmental carcinogens...
June 11, 2018: European Journal of Cancer
James E Enstrom
No abstract text is available yet for this article.
April 2018: Dose-response: a Publication of International Hormesis Society
S M J Mortazavi
Recent studies show that short-term exposure to ambient particulate matter is associated with more emergency department visits and hospitalizations for pneumonia as well as increased mortality and increased health care costs among older adults. Moreover, exposure to ambient particulate matter is shown to be connected with an increased rate of daily mortality and hospitalizations due to cardiovascular diseases (CVDs). The association between short-term exposures to particulate matter with a diameter less than 2...
June 12, 2018: Reviews on Environmental Health
Kimberly Berger, Brian J Malig, Sina Hasheminassab, Dharshani L Pearson, Constantinos Sioutas, Bart Ostro, Rupa Basu
BACKGROUND: Exposure to ambient fine particulate matter (PM2.5) has been linked with premature mortality, but sources of PM2.5 have been less studied. METHODS: We evaluated associations between source-specific PM2.5 exposures and cause-specific short-term mortality in eight California locations from 2002-2011. Speciated PM2.5 measurements were source-apportioned using Positive Matrix Factorization into eight sources and combined with death certificate data. We utilized time-stratified case-crossover analysis with conditional logistic regression by location, and meta-analysis to calculate pooled estimates...
June 6, 2018: Epidemiology
Baiyang Sun, Yanfeng Shi, Xiaozhe Yang, Tong Zhao, Junchao Duan, Zhiwei Sun
Exposure to airborne particulate matter (PM) does great harm to the health of human beings. To date, PM exposure has been closely associated with respiratory and cardiovascular diseases, as well as some types of cancer. As the associations of PM with the adverse health effects are well documented in literatures, the underlying mechanisms have not been completely clarified. With the field of epigenetics rising in recent years, PM-associated epigenetic alterations have gradually turned into the hot research topic...
June 5, 2018: Ecotoxicology and Environmental Safety
Yuanchen Chen, Lu Zang, Wei Du, Da Xu, Guofeng Shen, Quan Zhang, Qiaoli Zou, Jinyuan Chen, Meirong Zhao, Defei Yao
In recent years, ambient air has been severely contaminated by particulate matters (PMs) and some gas pollutants (nitrogen dioxide (NO2 ) and sulfur dioxide (SO2 )) in China, and many studies have demonstrated that exposure to these pollutants can induce great adverse impacts on human health. The concentrations of the pollutants were much higher in winter than those in summer, and the average concentrations in this studied area were lower than those in northern China. In the comparison between high-resolution emission inventory and spatial distribution of PM2...
June 6, 2018: Environmental Science and Pollution Research International
Bertrand Fougère, Yann Landkocz, Capucine Lepers, Perrine J Martin, Lucie Armand, Nicolas Grossin, Anthony Verdin, Eric Boulanger, Pierre Gosset, François Sichel, Pirouz Shirali, Sylvain Billet
BACKGROUND: Classified as carcinogenic to humans by the IARC in 2013, fine air particulate matter (PM2.5 ) can be inhaled and retained into the lung or reach the systemic circulation. This can cause or exacerbate numerous pathologies to which the elderly are often more sensitive. METHODS: In order to estimate the influence of age on the development of early cellular epigenetic alterations involved in carcinogenesis, peripheral blood mononuclear cells sampled from 90 patients from three age classes (25-30, 50-55 and 75-80 years old) were ex vivo exposed to urban PM2...
May 31, 2018: Experimental Gerontology
Ericka Marel Quezada-Maldonado, Yesennia Sánchez-Pérez, Yolanda I Chirino, Felipe Vaca-Paniagua, Claudia M García-Cuellar
Particulate matter (PM) is an environmental pollutant that has been associated with an increased risk for lung cancer. PM exposure induces cellular alterations and the deregulation of cell signaling pathways. However other mechanisms such as microRNAs deregulation, might be involved in the development and progression of some types of epithelial cancer. The aim of this work was to evaluate miRNA expression in epithelial lung cells after exposure to PM10 and to identify the possible gene targets of deregulated miRNAs...
October 2018: Environmental Pollution
Mohammed Jawad, Thomas Eissenberg, Rola Salman, Eric Soule, Karem H Alzoubi, Omar F Khabour, Nareg Karaoghlanian, Rima Baalbaki, Rachel El Hage, Najat A Saliba, Alan Shihadeh
BACKGROUND: Studies that assess waterpipe tobacco smoking behaviour and toxicant exposure generally use controlled laboratory environments with small samples that may not fully capture real-world variability in human behaviour and waterpipe products. This study aimed to conduct real-time sampling of waterpipe tobacco use in natural environments using an in situ device. METHODS: We used the REALTIME sampling instrument: a validated, portable, self-powered device designed to sample automatically a fixed percentage of the aerosol flowing through the waterpipe mouthpiece during every puff...
May 28, 2018: Tobacco Control
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