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Particulate Matter Cancer

Zhongqi Chen, Ningfei Ji, Zhengxia Wang, Chaojie Wu, Zhixiao Sun, Yan Li, Fan Hu, Zibin Wang, Mao Huang, Mingshun Zhang
Accumulating evidence indicates that fine particulate matter (PM2.5) exposure is associated with many cardiopulmonary diseases, particularly lung carcinoma. Nevertheless, the underlying biological mechanisms by which PM2.5 exposure initiates and aggravates lung carcinoma remain elusive. In the present study, we collected PM2.5 in Nanjing and explored the mechanisms underlying the oncogenic roles of PM2.5 in the murine lung carcinoma cell line LLC in vitro and in vivo . PM2.5 was closely attached to and internalized by lung cancer cells...
December 1, 2018: Journal of Biomedical Nanotechnology
Yu-Hua Chu, Syuan-Wei Kao, Disline Manli Tantoh, Pei-Chieh Ko, Shou-Jen Lan, Yung-Po Liaw
The aim of this study was to investigate the association between fine particulate matter 2.5 (PM2.5 ) and oral cancer among Taiwanese men. Four linked data sources including the Taiwan Cancer Registry, Adult Preventive Medical Services Database, National Health Insurance Research Database, and Air Quality Monitoring Database were used. Concentrations of sulfur dioxide, carbon monoxide, ozone, NOx (nitrogen monoxide and nitrogen dioxide), coarse particulate matter (PM10-2.5 ) and PM2.5 in 2009 were assessed in quartiles...
October 9, 2018: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
Muhammad Ubaid Ali, Guijian Liu, Balal Yousaf, Habib Ullah, Qumber Abbas, Mehr Ahmad Mujtaba Munir
Airborne particulate matter (PM) that is a heterogeneous mixture of particles with a variety of chemical components and physical features acts as a potential risk to human health. The ability to pose health risk depends upon the size, concentration and chemical composition of the suspended particles. Potential toxic elements (PTEs) associated with PM have multiple sources of origin, and each source has the ability to generate multiple particulate PTEs. In urban areas, automobile, industrial emissions, construction and demolition activities are the major anthropogenic sources of pollution...
October 8, 2018: Environmental Geochemistry and Health
Philip Wolfe, Kenneth Davidson, Charles Fulcher, Neal Fann, Margaret Zawacki, Kirk R Baker
By-products of mobile source combustion processes, such as those associated with gasoline- and diesel-powered engines, include direct emissions of particulate matter as well as precursors to particulate matter and ground-level ozone. Human exposure to fine particulate matter with an aerodynamic diameter smaller than 2.5 μm (PM2.5 ) is associated with increased incidence of premature mortality and morbidity outcomes. This study builds upon recent, detailed source-apportionment air quality modeling to project the health-related benefits of reducing PM2...
September 21, 2018: Science of the Total Environment
Xuelu Fan, Zhuo Chen, Longchao Liang, Guangle Qiu
The polycyclic aromatic hydrocarbons (PAHs) bound to fine particulate matter (PM2.5 ) can cause long-term adverse health consequences and are a public concern. A total of 144 PM2.5 -bound PAHs samples collected from Guiyang City, a typical plateau montane area in southwest China, from September 2012 to August 2013 were investigated to clarify their concentration, distribution, and potential sources. The health exposure risk also was evaluated. The samplers equipped with 90-mm glass fibre filters were operated at a flow rate of 100 L min-1 for 24 h...
October 5, 2018: Archives of Environmental Contamination and Toxicology
Jessica L Barnes, Maria Zubair, Kaarthik John, Miriam C Poirier, Francis L Martin
Humans are variously and continuously exposed to a wide range of different DNA-damaging agents, some of which are classed as carcinogens. DNA damage can arise from exposure to exogenous agents, but damage from endogenous processes is probably far more prevalent. That said, epidemiological studies of migrant populations from regions of low cancer risk to high cancer risk countries point to a role for environmental and/or lifestyle factors playing a pivotal part in cancer aetiology. One might reasonably surmise from this that carcinogens found in our environment or diet are culpable...
October 3, 2018: Biochemical Society Transactions
Patrick Amoatey, Hamid Omidvarborna, Mahad Said Baawain, Abdullah Al-Mamun
Indoor air pollution is one of the human health threat problems in the Gulf Cooperation Council (GCC) countries. In these countries, due to unfavorable meteorological conditions, such as elevated ambient temperature, high relative humidity, and natural events such as dust storms, people spend a substantial amount of their time in indoor environments. In addition, production of physical and biological aerosols from air conditioners, cooking activities, burning of Arabian incense, and overcrowding due to pilgrimage programs are common causes of low quality indoor air in this region...
October 1, 2018: Environment International
Xiaoning Lei, Joshua E Muscat, Zhongsi Huang, Chao Chen, Guangli Xiu, Jiahui Chen
Fine particulate matters (PM2.5 ) are the core pollutants of haze episode, which pose a serious threat to the human health of developing countries. However, the mechanisms involved in PM2.5 -induced hazard influence are not to fully elucidated. In the present study, human lung epithelial cells (A549) were exposed to various concentrations of PM2.5 samples collected from Shanghai, China. Illumina RNA-Seq method with transcriptome, Gene Ontology (GO), and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis were further employed to identify the detrimental effects of PM2...
October 1, 2018: Environmental Science and Pollution Research International
Tao Li, Rong Hu, Zi Chen, Qiyuan Li, Shouxiong Huang, Zhou Zhu, Lin-Fu Zhou
Air pollution is a world public health problem. Particulate matter (PM), a mix of solid and liquid particles in the air, becomes an increasing concern in the social and economic development of China. For decades, epidemiological studies have confirmed the association between fine particle pollutants and respiratory diseases. It has been reported in different populations that increased Fine particulate matter (PM2.5 ) concentrations cause elevated susceptibility to respiratory diseases, including acute respiratory distress, asthma, chronic obstructive pulmonary disease, and lung cancer...
September 2018: Chronic diseases and translational medicine
Alexandra J White, Patrick T Bradshaw, Ghassan B Hamra
Purpose of Review: Breast cancer is the most common cancer diagnosed among US women. Air pollution is a pervasive mixture of chemicals containing carcinogenic compounds and chemicals with endocrine disrupting properties. In the present review, we examine the epidemiologic evidence regarding the association between air pollution measures and breast cancer risk. Recent Findings: We identified seventeen studies evaluating the risk of breast cancer associated with air pollution...
June 2018: Current Epidemiology Reports
Thomas Gredner, Gundula Behrens, Christian Stock, Hermann Brenner, Ute Mons
BACKGROUND: Causal relationships with the occurrence of cancer have been established for a number of infections and environmental risk factors. METHODS: Numbers and proportions (population-attributable fractions, PAF) of cancer cases attributable to these factors in Germany were calculated by sex and age groups for ages 35 to 84 years based on population projections, national cancer incidence, exposure data, and published risk estimates. RESULTS: For 2018, more than 17 600 cancer cases (4...
September 3, 2018: Deutsches Ärzteblatt International
Dario Consonni, Michele Carugno, Sara De Matteis, Francesco Nordio, Giorgia Randi, Martina Bazzano, Neil E Caporaso, Margaret A Tucker, Pier Alberto Bertazzi, Angela C Pesatori, Jay H Lubin, Maria Teresa Landi
OBJECTIVE: Cohort studies in Europe, but not in North-America, showed an association between exposure to outdoor particulate matter with aerodynamic diameter ≤10 μm (PM10) and lung cancer risk. Only a case-control study on lung cancer and PM10 in South Korea has so far been performed. For the first time in Europe we analyzed quantitatively this association using a case-control study design in highly polluted areas in Italy. METHODS: The Environment And Genetics in Lung cancer Etiology (EAGLE) study, a population-based case-control study performed in the period 2002-2005 in the Lombardy Region, north-west Italy, enrolled 2099 cases and 2120 controls frequency-matched for area of residence, gender, and age...
2018: PloS One
Jong-Hun Kim, In-Hwan Oh, Jae-Hyun Park, Hae-Kwan Cheong
Background: Ambient fine particulate matter (PM2.5 ) is the major environmental health risk factor in Korea. Exposure to PM2.5 has been a growing public concern nationwide. With the rapid aging of the Korean population, the health effects attributable to long-term exposure to PM2.5 were expected to increase further in the future. We aimed to estimate premature deaths attributable to long-term exposure to ambient PM2.5 in Korea. Methods: A modelled estimation of long-term exposure to PM2...
September 10, 2018: Journal of Korean Medical Science
Hong Zhang, Lian Xue, Bingyan Li, Hailin Tian, Zengli Zhang, Shasha Tao
Fine particulate matter (PM 2.5) is a well-known air pollutant threatening public health. Studies has confirmed that long-term exposure to the particles could reduce the pulmonary function, cause exacerbation of asthma and chronic obstructive pulmonary disease, and increase incidence and mortality of lung cancer. Bixin is a natural compound that is widely used as a food additive. Our previous studies demonstrated that bixin i.p. administration could protect against particles intratracheal exposure (56 days)-induced lung injury in an Nrf2-dependent manner...
October 2018: Free Radical Biology & Medicine
Gudrun Weinmayr, Marie Pedersen, Massimo Stafoggia, Zorana J Andersen, Claudia Galassi, Jule Munkenast, Andrea Jaensch, Bente Oftedal, Norun H Krog, Geir Aamodt, Andrei Pyko, Göran Pershagen, Michal Korek, Ulf De Faire, Nancy L Pedersen, Claes-Göran Östenson, Debora Rizzuto, Mette Sørensen, Anne Tjønneland, Bas Bueno-de-Mesquita, Roel Vermeulen, Marloes Eeftens, Hans Concin, Alois Lang, Meng Wang, Ming-Yi Tsai, Fulvio Ricceri, Carlotta Sacerdote, Andrea Ranzi, Giulia Cesaroni, Francesco Forastiere, Kees de Hoogh, Rob Beelen, Paolo Vineis, Ingeborg Kooter, Ranjeet Sokhi, Bert Brunekreef, Gerard Hoek, Ole Raaschou-Nielsen, Gabriele Nagel
INTRODUCTION: Previous analysis from the large European multicentre ESCAPE study showed an association of ambient particulate matter <2.5 μm (PM2.5 ) air pollution exposure at residence with the incidence of gastric cancer. It is unclear which components of PM are most relevant for gastric and also upper aerodigestive tract (UADT) cancer and some of them may not be strongly correlated with PM mass. We evaluated the association between long-term exposure to elemental components of PM2...
November 2018: Environment International
Ruijin Li, Lifang Zhao, Li Zhang, Minghui Chen, Jing Shi, Chuan Dong, Zongwei Cai
Ambient fine particulate matter (PM2.5 ) is a complex mixture associated with lung cancer risk. PM2.5 -bound nitro-polycyclic aromatic hydrocarbons (NPAHs) have been demonstrated to possess mutagenicity and carcinogenicity. Previous studies showed that PM2.5 induced DNA damage, whereas there is little knowledge of whether 9-nitroanthracene (9-NA), a typical compound of NPAHs in PM2.5 , causes DNA damage. Also, the regulating mechanisms of PM2.5 and 9-NA in DNA damage and repair are not yet fully established...
September 1, 2017: Toxicology Research
Joshua K Kibet, Bornes C Mosonik, Vincent O Nyamori, Silas M Ngari
BACKGROUND: The atmosphere has become a major transport corridor for free radicals and particulate matter from combustion events. The motivation behind this study was to determine the nature of particulate emissions and surface bound radicals formed during the thermal degradation of diesel blends in order to assess the health and environmental hazards of binary transport fuels. METHODOLOGY: Accordingly, this contribution explored the interactions that occur when Croton megalocarpus biodiesel and fossil diesel in the ratio of 1:1 by weight were co-pyrolyzed in a quartz reactor at a residence time of 0...
August 7, 2018: Chemistry Central Journal
Zhiguo Cao, Leicheng Zhao, Xuejie Meng, Xiaotu Liu, Peipei Wu, Xinyi Fan, Shihua Wang, Jianye Jie, Zheng Miao, Xiaopeng Xu, Mohai Shen, Qingwei Bu
The health impact of haze is of great concern; however, few air quality studies have investigated trace pollutant contamination in the air. Size-segregated atmospheric particles (nine size fractions derived from PM10 ) were collected in dwelling (indoor) and traffic (outdoor) environments in Xinxiang, China, during light pollution conditions (air quality index (AQI), 60-90) and heavy pollution conditions (AQI, 350-550), and they were analysed for halogenated flame retardants (HFRs), including polybrominated diphenyl ethers (PBDEs), novel brominated flame retardants (NBFRs) and Dechlorane Plus (DP) isomers...
October 5, 2018: Journal of Hazardous Materials
Morteza Seifi, Sadegh Niazi, Graham Johnson, Vahideh Nodehi, Masud Yunesian
The relationship between air pollution and childhood cancer is inconclusive. We investigated the associations between exposure to ambient air pollution and childhood cancers in Tehran, Iran. This project included children between 1 and 15 years-of-age with a cancer diagnosis by the Center for the Control of Non Communicable Disease (n = 161) during 2007 to 2009. Controls were selected randomly within the city using a Geographic Information System (GIS) (n = 761). The cases were geocoded based on exact home addresses...
January 1, 2019: Science of the Total Environment
Changwoo Han, Soontae Kim, Youn-Hee Lim, Hyun-Joo Bae, Yun-Chul Hong
Background: We aimed to evaluate the spatial and temporal trends of the health burden attributable to particulate matter less than 2.5 µm in diameter (PM2.5 ) in the metropolitan cities and provinces of the Korea. Methods: We used modeled PM2.5 concentration data for the basic administrative levels, comprising the cities and the provinces of Korea, the corresponding annual population census data for each level, and the age and cause specific mortality data. We applied cause-specific integrated exposure-response functions to calculate the premature mortality attributable to ambient PM2...
July 23, 2018: Journal of Korean Medical Science
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