keyword
MENU ▼
Read by QxMD icon Read
search

Endothelial corneal dystrophy

keyword
https://www.readbyqxmd.com/read/28089285/thick-keratoconic-cornea-associated-with-posterior-polymorphous-corneal-dystrophy
#1
K Zaarour, E Slim, J Antoun, N Waked
INTRODUCTION: We herein report a case of bilateral unusually thick non-edematous keratoconic corneas with associated endothelial features of posterior polymorphous corneal dystrophy (PPCD). CASE REPORT: We report the case of a 27-year-old myopic woman who presented for refractive surgery. Slit lamp exam showed bilateral corneal protrusion with diffuse deep stromal and endothelial vesicular opacities and small paracentral bands. Topography showed generalized advanced corneal steepening in both eyes with increased anterior and posterior central corneal elevations in comparison to the best fit sphere...
January 12, 2017: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/28079694/eventual-endothelial-failure-after-initial-corneal-cleaning-after-a-detached-endothelial-graft-in-fuchs-dystrophy
#2
Takahiko Hayashi, Itaru Oyakawa, Naoko Kato
No abstract text is available yet for this article.
January 11, 2017: Cornea
https://www.readbyqxmd.com/read/28060074/eventual-endothelial-failure-after-initial-corneal-clearing-after-a-detached-endothelial-graft-in-fuchs-dystrophy
#3
Hyunjoo J Lee, Wuqaas M Munir
PURPOSE: To report a case of eventual corneal endothelial cell failure after spontaneous resolution of corneal edema after failed Descemet membrane endothelial keratoplasty (DMEK). METHODS: Retrospective case report. RESULTS: A 56-year-old man with Fuchs endothelial corneal dystrophy underwent cataract and DMEK surgery in the left eye. The transplanted DMEK graft detached in the early postoperative period and formed a peripheral scroll. Despite graft detachment, corneal edema resolved with endothelial cell repopulation of the central cornea...
February 2017: Cornea
https://www.readbyqxmd.com/read/28046031/confirmation-of-the-ovol2-promoter-mutation-c-307t-c-in-posterior-polymorphous-corneal-dystrophy-1
#4
Doug D Chung, Ricardo F Frausto, Aleck E Cervantes, Katherine M Gee, Marina Zakharevich, Evelyn M Hanser, Edwin M Stone, Elise Heon, Anthony J Aldave
PURPOSE: To identify the genetic basis of posterior polymorphous corneal dystrophy (PPCD) in families mapped to the PPCD1 locus and in affected individuals without ZEB1 coding region mutations. METHODS: The promoter, 5' UTR, and coding regions of OVOL2 was screened in the PPCD family in which linkage analysis established the PPCD1 locus and in 26 PPCD probands who did not harbor a ZEB1 mutation. Copy number variation (CNV) analysis in the PPCD1 and PPCD3 intervals was performed on DNA samples from eight probands using aCGH...
2017: PloS One
https://www.readbyqxmd.com/read/28009792/clinical-features-in-children-with-posterior-polymorphous-corneal-dystrophy
#5
Ye Jin Ahn, Soon Il Choi, Hae Ri Yum, Sun Young Shin, Shin Hae Park
PURPOSE: To describe clinical features in children diagnosed with posterior polymorphous corneal dystrophy (PPCD) in their first or second decade of life. METHODS: A retrospective study was performed with the medical records of seven unrelated Korean pediatric patients who were diagnosed with PPCD and were followed up for a minimum of 3 years. Thorough ocular examinations were performed, including best-corrected visual acuity, intraocular pressure, refractive and keratometric measurements, slit-lamp biomicroscopy, and specular microscopy at all visits...
December 22, 2016: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/28002107/astigmatism-correction-with-toric-intraocular-lenses-in-descemet-membrane-endothelial-keratoplasty-triple-procedures
#6
Hideaki Yokogawa, P James Sanchez, Zachary M Mayko, Michael D Straiko, Mark A Terry
PURPOSE: To report the clinical efficacy of astigmatism correction with toric intraocular lenses (IOLs) in patients undergoing the Descemet membrane endothelial keratoplasty (DMEK) triple procedure and to evaluate the accuracy of the correction. METHODS: Fifteen eyes of 10 patients who received cataract extraction, toric IOL placement, and DMEK surgery for Fuchs corneal dystrophy and cataracts were evaluated. The cylinder power of toric IOLs was determined by an online toric calculator with keratoscopy measurements obtained using Scheimpflug corneal imaging...
December 20, 2016: Cornea
https://www.readbyqxmd.com/read/27994806/descemet-stripping-automated-endothelial-keratoplasty-in-fuchs-endothelial-dystrophy-versus-pseudophakic-bullous-keratopathy
#7
Mohammad Ali Javadi, Sepehr Feizi, Roya Jafari, Firooz Mirbabaee, Vahid Ownagh
PURPOSE: To compare clinical and confocal scan outcomes after Descemet stripping automated endothelial keratoplasty (DSAEK) performed for Fuchs' endothelial dystrophy (FED) versus pseudophakic bullous keratopathy (PBK). METHODS: This retrospective comparative study included 47 consecutive eyes of 39 patients with the diagnosis of FED (n = 29, group 1) or PBK (n = 18, group 2) that underwent DSAEK. Clinical outcomes were compared between the study groups. At the final follow-up examination, confocal microscopy was used to measure and compare central corneal and graft thickness as well as endothelial cell density and morphology between the two groups...
October 2016: Journal of Ophthalmic & Vision Research
https://www.readbyqxmd.com/read/27986425/two-year-course-of-corneal-densitometry-after-descemet-membrane-endothelial-keratoplasty-dmek
#8
Friederike Schaub, Philip Enders, Cornelius Bluhm, Björn O Bachmann, Claus Cursiefen, Ludwig M Heindl
PURPOSE: To investigate the two-year course of corneal densitometry following Descemet membrane endothelial keratoplasty (DMEK) for Fuchs endothelial dystrophy (FED). DESIGN: Retrospective, interventional case series. METHODS: Densitometry values (corneal light backscatter in greyscale units) measured by Scheimpflug-based imaging and clinical records of 160 eyes of 160 patients undergoing DMEK for FED were reviewed. Outcome measures included densitometry data in 4 corneal layers (anterior layer (AL), central layer (CL), posterior layer (PL), and total layer (TL)) and 2 annuli (central annular zone 0-2mm and peripheral zone 2-10mm), central corneal thickness (CCT), best spectacle-corrected visual acuity (BSCVA), and endothelial cell density (ECD) prior to DMEK and at 1, 3, 6, 12, and 24 months postoperatively...
December 13, 2016: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/27974291/organ-cultured-prestripped-donor-tissue-for-dmek-surgery-clinical-outcomes
#9
Johannes Menzel-Severing, Friedrich E Kruse, Theofilos Tourtas
AIM: To determine whether clinical performance is negatively affected by prestripping Descemet membrane endothelial keratoplasty (DMEK) grafts from organ-cultured corneas. METHODS: We reviewed clinical records of all patients who underwent DMEK surgery for Fuchs endothelial dystrophy between 28 October 2014 and 11 August 2015. Grafts had been prepared from organ-cultured corneoscleral buttons 24 hours prior to surgery or during surgery. We included only patients for which at least one follow-up examination was available at a minimum of 2 months postoperatively...
December 14, 2016: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/27965261/very-early-endothelial-cell-loss-after-penetrating-keratoplasty-with-organ-cultured-corneas
#10
Anne Sophie Gauthier, Thibaud Garcin, Gilles Thuret, Zhiguo He, Remy Jullienne, Marie Caroline Trone, Chaker Nefzaoui, Sophie Acquart, Fabien Forest, Michel Péoc'h, Bernard Delbosc, Philippe Gain
AIMS: After keratoplasty, postoperative endothelial cell loss is calculated between the eye bank endothelial cell density (ebECD) and the postoperative specular microscopy (SM). To elucidate the very early cell loss, always described after penetrating keratoplasty (PK), we designed two complementary studies. METHODS: (1) Clinical prospective study of 90 consecutive PKs (keratoconus, Fuchs' corneal dystrophy, lattice dystrophy, bullous keratopathy) with organ-cultured corneas and postoperative follow-up by SM at day 5 (D5), D15, month 1 (M1) and M3...
December 13, 2016: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/27956322/fuch-s-dystrophy-associated-with-radial-keratotomy-lamellar-or-perforating-keratoplasty
#11
P Rodriguez-Ausin, D Antolin-Garcia, L Santamaria Garcia, A-B Blazquez-Fernandez
CASE REPORT: A 70 year-old male patient with a history of radial keratotomy suffering from Fuch's dystrophy and a cataract. The patient received a two-step surgery: lens phacoemulsification and intraocular lens implant, followed by descemet stripping automated endothelial keratoplasty in both eyes, four months later. There were no complications apart from a recurrent cystoid macular oedema in both eyes. The best corrected visual acuity was 20/40 both eyes, and the patient was satisfied...
December 7, 2016: Archivos de la Sociedad Española de Oftalmología
https://www.readbyqxmd.com/read/27941386/ten-year-clinical-outcome-of-the-first-patient-undergoing-descemet-membrane-endothelial-keratoplasty
#12
Lamis Baydoun, Thomas Müller, Itay Lavy, Jack Parker, Marina Rodriguez-Calvo-de-Mora, Vasilios S Liarakos, Isabel Dapena, Gerrit R J Melles
PURPOSE: To describe the 10-year clinical outcome of the first patient worldwide who underwent Descemet membrane endothelial keratoplasty (DMEK). METHODS: In 2006, a 63-year-old man presented at the Melles Cornea Clinic, Rotterdam, with bilateral Fuchs endothelial dystrophy and cataract. After phacoemulsification, in vivo DMEK was performed in the left eye and 10 months later in the right eye. Best spectacle-corrected visual acuity (BSCVA), endothelial cell density, pachymetry, and complications were recorded every 6 months over a 10-year period...
December 8, 2016: Cornea
https://www.readbyqxmd.com/read/27925686/slc4a11-three-dimensional-homology-model-rationalizes-corneal-dystrophy-causing-mutations
#13
Katherine E Badior, Kumari Alka, Joseph R Casey
We studied the structural effects of point mutations of a membrane protein that cause genetic disease. SLC4A11 is a membrane transport protein (OH(-) /H(+) /NH3 /H2 O) of basolateral corneal endothelium, whose mutations cause some cases of congenital hereditary endothelial dystrophy and Fuchs endothelial corneal dystrophy. We created a three-dimensional homology model of SLC4A11 membrane domain, using Band 3 (SLC4A1) crystal structure as template. The homology model was assessed in silico and by analysis of mutants designed on the basis of the model...
December 7, 2016: Human Mutation
https://www.readbyqxmd.com/read/27918355/experienced-dsaek-surgeon-s-transition-to-dmek-outcomes-comparing-the-last-100-dsaek-surgeries-with-the-first-100-dmek-surgeries-exclusively-using-previously-published-techniques
#14
Paul M Phillips, Louis J Phillips, Valliamai Muthappan, Charlene M Maloney, Christopher N Carver
PURPOSE: To compare outcomes of Descemet stripping automated endothelial keratoplasty (DSAEK) and Descemet membrane endothelial keratoplasty (DMEK) when an experienced DSAEK surgeon transitions to DMEK while following 2 published endothelial keratoplasty surgical techniques. METHODS: This is a retrospective review of 200 eyes of 132 patients with Fuchs corneal dystrophy that underwent endothelial keratoplasty performed by one surgeon. Published, standardized techniques were followed for both DSAEK and DMEK...
December 1, 2016: Cornea
https://www.readbyqxmd.com/read/27897118/smoking-and-eye-pathologies-a-systemic-review-part-i-anterior-eye-segment-pathologies
#15
Małgorzata Nita, Andrzej Grzybowski
BACKGROUND: Tobacco smoking has detrimental influence on human health and is one of the leading causes of preventable mortality worldwide, associated with lung cancer, chronic obstructive lung disease and cardiovascular disease. AIM: The analysis of the influence of tobacco smoking on pathology of the anterior segment of the eye in adults and children. METHODS: A comprehensive review of the literature performed through MEDLINE and PubMed searches, was published during the period 2000-2016...
November 29, 2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27885526/twelve-year-follow-up-of-penetrating-keratoplasty
#16
Takashi Ono, Sosuke Ishiyama, Takeshi Hayashidera, Yosai Mori, Ryohei Nejima, Kazunori Miyata, Shiro Amano
PURPOSE: To evaluate the long-term outcomes of penetrating keratoplasty (PKP) according to the corneal disease diagnosis and the number of PKP procedures performed. METHODS: Five-hundred-and-nine eyes from 403 patients who underwent PKP at Miyata Eye Hospital in Japan from 1998 through 2014, were included in this study. Medical charts were retrospectively examined to ascertain the corneal disease diagnosis and the period of graft survival. Graft survival rates were compared among various corneal disease diagnoses and among the number of PKP procedures performed...
November 24, 2016: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/27820951/elevated-cytokine-levels-in-the-aqueous-humor-of-eyes-with-bullous-keratopathy-and-low-endothelial-cell-density
#17
Takefumi Yamaguchi, Kazunari Higa, Terumasa Suzuki, Naohiko Nakayama, Yukari Yagi-Yaguchi, Murat Dogru, Yoshiyuki Satake, Jun Shimazaki
Purpose: To evaluate cytokine levels in the aqueous humor (AqH) of eyes with bullous keratopathy (BK) and low endothelial cell density (ECD). Methods: A total of 145 AqH samples (60 BK, 16 low ECD, 35 corneal diseases with normal ECD, and 34 normal controls) were collected from consecutive patients who underwent corneal transplantation or cataract surgery. None of the patients had any clinically apparent inflammation at the time of AqH collection. The AqH levels of cytokines (IL-1α, IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12p70, IL-13, IL-17A, IFN-α, IFN-γ, monocyte chemotactic protein [MCP]-1, TNF-α, E-selectin, P-selectin, soluble intercellular adhesion molecule [sICAM]-1, granulocyte-macrophage colony-stimulating factor [GM-CSF], macrophage inflammatory protein [MIP] -1α and MIP-1β) were compared among the groups...
November 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27805532/visual-rehabilitation-after-penetrating-keratoplasty
#18
Leyla Asena, Dilek D Altınörs
OBJECTIVES: Here, our aim was to report our treatment strategies and their results performed for visual rehabilitation after penetrating keratoplasty. MATERIALS AND METHODS: The medical records of 98 patients (54 male/44 female), with results from 104 eyes, who underwent penetrating keratoplasty between January 2013 and January 2015 at the Baskent University Faculty of Medicine, Department of Ophthalmology were reviewed. Patient age, indication for penetrating keratoplasty, interventions performed for visual rehabilitation, follow-up duration, topographic and refractive astigmatism at the end of follow-up, and final best corrected visual acuity results were recorded...
2016: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/27802523/restoration-of-mitochondrial-integrity-telomere-length-and-sensitivity-to-oxidation-by-in-vitro-culture-of-fuchs-endothelial-corneal-dystrophy-cells
#19
Sébastien P Gendron, Mathieu Thériault, Stéphanie Proulx, Isabelle Brunette, Patrick J Rochette
Purpose: Fuchs' endothelial corneal dystrophy (FECD), a degenerative disease of the corneal endothelium that leads to vision loss, is a leading cause of corneal transplantation. The cause of this disease is still unknown, but the implication of oxidative stress is strongly suggested. In this study, we analyzed the impact of FECD on mitochondrial DNA (mtDNA) integrity and telomere length, both of which are affected by the oxidative status of the cell. Methods: We compared the levels of total mtDNA, mtDNA common deletion (4977 bp), and relative telomere length in the corneal endothelial cells of fresh Descemet's membrane-endothelium explants and cultured cells from healthy and late stage FECD subjects...
November 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27768788/microrna-profiles-qualify-phenotypic-features-of-cultured-human-corneal-endothelial-cells
#20
Morio Ueno, Kazuko Asada, Munetoyo Toda, Asako Hiraga, Monty Montoya, Chie Sotozono, Shigeru Kinoshita, Junji Hamuro
Purpose: To elucidate a noninvasive method to qualify and identify cultured human corneal endothelial cells (cHCECs) devoid of cell-state transition and adaptable for cell-based therapy. Methods: The variations of cHCECs in their composition of heterogeneous subpopulations (SPs) were verified in relation to their surface cluster-of-differentiation (CD) markers and their morphology. The profiles of microRNA (miRNA) in cultured cells or supernatants were detected by 3D-Gene Human microRNA Chips (Toray Industries, Inc...
October 1, 2016: Investigative Ophthalmology & Visual Science
keyword
keyword
16587
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"