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https://www.readbyqxmd.com/read/30316080/a-new-drug-carrier-with-oxygen-generation-function-for-modulating-tumor-hypoxia-microenvironment-in-cancer-chemotherapy
#1
Zhe Zhang, Na Niu, Xi Gao, Fuqin Han, Zhijun Chen, Shujun Li, Jian Li
Hypoxia is the main characteristic of tumor microenvironment, and the one of the key factors that cause the drug resistance of cancer cells for chemotherapy. Anticancer drug such as DOX cannot react with sufficient oxygen to produce reactive oxygen species (ROS) in hypoxic environment, which affects the therapeutic efficiency of the drug. In this work, we constructed a multi-functional nano-carrier (named as FeSiAuO) containing Fe3 O4 , mesoporous SiO2 and Au2 O3 with magnetic, large surface ratio and light induced oxygen production properties...
October 5, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/30310607/a-redox-activated-theranostic-nanoagent-toward-multi-mode-imaging-guided-chemo-photothermal-therapy
#2
Ting-Ting Zhang, Cong-Hui Xu, Wei Zhao, Yu Gu, Xiang-Ling Li, Jing-Juan Xu, Hong-Yuan Chen
Development of tumor microenvironment responsive and modulating theranostic nano-systems is of great importance for specific and efficient cancer therapy. Herein, we report a redox-sensitive nanoagent combining manganese dioxide (MnO2 ) and gold nanoshell coated silicon nanoparticles for synergistic chemo-photothermal therapy of hypoxia solid tumors. In highly reducing tumor tissues, the outer MnO2 nanosheet with the loaded drug would be dissociated by intracellular glutathione (GSH), resulting in on-demand drug release, as well as generating Mn2+ ions which provided high contrast magnetic resonance imaging (MRI), and fluorescence imaging (FI) in vitro and in vivo ...
September 7, 2018: Chemical Science
https://www.readbyqxmd.com/read/30307701/tumor-ph-responsive-dissociable-albumin-tamoxifen-nanocomplexes-enabling-efficient-tumor-penetration-and-hypoxia-relief-for-enhanced-cancer-photodynamic-therapy
#3
Zhijuan Yang, Qian Chen, Jiawen Chen, Ziliang Dong, Rui Zhang, Jingjing Liu, Zhuang Liu
Despite the promises of applying nano-photosensitizers (nano-PSs) for photodynamic therapy (PDT) against cancer, severe tumor hypoxia and limited tumor penetration of nano-PSs would lead to nonoptimized therapeutic outcomes of PDT. Therefore, herein a biocompatible nano-PS is prepared by using tamoxifen (TAM), an anti-estrogen compound, to induce self-assembly of chlorin e6 (Ce6) modified human serum albumin (HSA). The formed HSA-Ce6/TAM nanocomplexes, which are stable under neutral pH with a diameter of ≈130 nm, would be dissociated into individual HSA-Ce6 and TAM molecules under the acidic tumor microenvironment, owing to the pH responsive transition of TAM from hydrophobic to hydrophilic...
October 11, 2018: Small
https://www.readbyqxmd.com/read/30234960/modulating-hypoxia-via-nanomaterials-chemistry-for-efficient-treatment-of-solid-tumors
#4
Yanyan Liu, Yaqin Jiang, Meng Zhang, Zhongmin Tang, Mingyuan He, Wenbo Bu
The common existence of hypoxia in solid tumors has been heavily researched because it renders tumors more resistant to most standard therapeutic methods, such as radiotherapy (RT), chemotherapy, and photodynamic therapy (PDT), and is associated with a more malignant phenotype and poor survival in patients with tumors. The development of hypoxia modulation methods for advanced therapeutic activity is therefore of great interest but remains a considerable challenge. Since the significant development of nanotechnology and nanomedicine, functionalized nanomaterials can be exploited as adjuvant "drugs" for these oxygen-dependent standard therapies or as hypoxia initiators for advanced new therapies to solid tumors...
September 20, 2018: Accounts of Chemical Research
https://www.readbyqxmd.com/read/30174496/nano-particle-engineered-atorvastatin-delivery-to-support-mesenchymal-stem-cell-survival-in-infarcted-myocardium
#5
Guang-Tao Yao, Li-Ping Song, Wan-Hua Xue, Guo-Hai Su, Ai-Hua Ning, Jin Wang
Atorvastatin (ATV) may support mesenchymal stem cells (MSC) survival in post-infarct myocardium (MI) as inflammatory reactions, oxidative stress and hypoxia condition get started in such tissues after damage. However, limited aqueous insolubility and rapid first-pass metabolism reduce the systemic availability of ATV. The aim of the present investigation was to develop ATV loaded nanoparticles (ATVNPs) which might ensure the maximum availability of ATV in systemic circulation for longer duration and to strengthen the support to MSC survival...
September 2018: Saudi Journal of Biological Sciences
https://www.readbyqxmd.com/read/30128231/mitochondria-targeted-artificial-nano-rbcs-for-amplified-synergistic-cancer-phototherapy-by-a-single-nir-irradiation
#6
Liang Zhang, Dong Wang, Ke Yang, Danli Sheng, Bin Tan, Zhigang Wang, Haitao Ran, Hengjing Yi, Yixin Zhong, Han Lin, Yu Chen
Phototherapy has emerged as a novel therapeutic modality for cancer treatment, but its low therapeutic efficacy severely hinders further extensive clinical translation and application. This study reports amplifying the phototherapeutic efficacy by constructing a near-infrared (NIR)-responsive multifunctional nanoplatform for synergistic cancer phototherapy by a single NIR irradiation, which can concurrently achieve mitochondria-targeting phototherapy, synergistic photothermal therapy (PTT)/photodynamic therapy (PDT), self-sufficient oxygen-augmented PDT, and multiple-imaging guidance/monitoring...
August 2018: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://www.readbyqxmd.com/read/30102510/tumor-oxygenation-and-hypoxia-inducible-factor-1-functional-inhibition-via-a-reactive-oxygen-species-responsive-nanoplatform-for-enhancing-radiation-therapy-and-abscopal-effects
#7
Lingtong Meng, Yali Cheng, Xiaoning Tong, Shaoju Gan, Yawen Ding, Yu Zhang, Chao Wang, Lei Xu, Yishen Zhu, Jinhui Wu, Yiqiao Hu, Ahu Yuan
Hypoxia, and hypoxia inducible factor-1 (HIF-1), can induce tumor resistance to radiation therapy. To overcome hypoxia-induced radiation resistance, recent studies have described nanosystems to improve tumor oxygenation for immobilizing DNA damage and simultaneously initiate oxygen-dependent HIF-1α degradation. However, HIF-1α degradation is incomplete during tumor oxygenation treatment alone. Therefore, tumor oxygenation combined with residual HIF-1 functional inhibition is crucial to optimizing therapeutic outcomes of radiotherapy...
August 28, 2018: ACS Nano
https://www.readbyqxmd.com/read/30096565/photosensitizer-crosslinked-in-situ-polymerization-on-catalase-for-tumor-hypoxia-modulation-enhanced-photodynamic-therapy
#8
Hairong Wang, Yu Chao, Jingjing Liu, Wenwen Zhu, Guanglin Wang, Ligeng Xu, Zhuang Liu
Tumor hypoxia is known to be one of critical factors that aggravate the tumor resistance to photodynamic therapy (PDT) in which oxygen is essential for tumor destruction. Herein, catalase, an enzyme to trigger hydrogen peroxide (H2 O2 ) decomposition, is modified by in-situ free radical polymerization, using meso-tetra(p-hydroxyphenyl) porphine (THPP) as the cross-linker to enable condensed grafting of short polyethylene glycol (PEG) chains on the protein surface as a permeable brush-like safeguard. The formulated catalase-entrapped nanocapsules (CAT-THPP-PEG) with enhanced enzyme stability can be labeled with 99m Tc4+ , a radioisotope ion that is chelated by the porphyrin structure of THPP, to allow in vivo single-photon emission computed tomography (SPECT) imaging...
October 2018: Biomaterials
https://www.readbyqxmd.com/read/29967937/conjugation-of-para-benzoquinone-of-cigarette-smoke-with-human-hemoglobin-leads-to-unstable-tetramer-and-reduced-cooperative-oxygen-binding
#9
Amrita Mitra, Amit Kumar Mandal
Besides multiple life-threatening diseases like lung cancer and cardiovascular disease, cigarette smoking is known to produce hypoxia, a state of inadequate oxygen supply to tissues. Hypoxia plays a pivotal role in the development of chronic obstructive pulmonary disease. Smoking during pregnancy imposes risk for the unborn child. In addition to carbon monoxide, conjugation of para-benzoquinone (pBQ), derived from cigarette smoke, with human hemoglobin (HbA) was also reported to contribute in hypoxia. In fact, conjugation of pBQ is more alarming than carbon monoxide as it is an irreversible covalent modification...
October 2018: Journal of the American Society for Mass Spectrometry
https://www.readbyqxmd.com/read/29791792/normalizing-tumor-microenvironment-based-on-photosynthetic-abiotic-biotic-nanoparticles
#10
Diwei Zheng, Bin Li, Lu Xu, Qiu-Ling Zhang, Jin-Xuan Fan, Chu-Xin Li, Xian-Zheng Zhang
Tumor hypoxia has attained the status of a core hallmark of cancer that globally affects the entire tumor phenotype. Reversing tumor hypoxia might offer alternative therapeutic opportunities for current anticancer therapies. In this research, a photosynthetic leaf-inspired abiotic/biotic nano-thylakoid (PLANT) system was designed by fusing the thylakoid membrane with synthetic nanoparticles for efficient O2 generation in vivo. Under 660 nm laser irradiation, the PLANT system exhibited intracellular O2 generation and the anaerobic respiration of the multicellular tumor spheroid was suppressed by PLANT as well...
May 31, 2018: ACS Nano
https://www.readbyqxmd.com/read/29704295/an-assembled-nanocomplex-for-improving-both-therapeutic-efficiency-and-treatment-depth-in-photodynamic-therapy
#11
Hongqian Cao, Lei Wang, Yang Yang, Juan Li, Yanfei Qi, Yue Li, Ying Li, Hao Wang, Junbai Li
Photodynamic therapy (PDT) shows unique selectivity and irreversible destruction toward treated tissues or cells, but still has several problems in clinical practice. One is limited therapeutic efficiency, which is attributed to hypoxia in tumor sites. Another is the limited treatment depth because traditional photosensitizes are excited by short wavelength light (<700 nm). An assembled nano-complex system composed of oxygen donor, two-photon absorption (TPA) species, and photosensitizer (PS) was synthesized to address both problems...
June 25, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29688912/tilianin-loaded-reactive-oxygen-species-scavenging-nano-micelles-protect-h9c2-cardiomyocyte-against-hypoxia-reoxygenation-induced-injury
#12
Yanfang Wang, Ying Wang, Xinchun Wang, Ping Hu
Previous studies have shown that tilianin alleviates ischemia-reperfusion-induced cardiomyocyte injury. However, its clinical translation has been hampered because of its insolubility in water. Tilianin-based nano-micelles that may overcome this critical issue are presented. A polyethylene glycol compound was covalently attached to propylene sulfide-formed amphiphilic diblock polymers. In the aqueous solution, tilianin is encapsulated in a hydrophobic shell to form nano-micelles. The Ph-PPS-PEG self-assembled into nanoscale micelles with a size of approximately 70 nm, termed "tilianin-loaded micelles" (TLMs)...
July 2018: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/29565139/smart-nanoreactors-for-ph-responsive-tumor-homing-mitochondria-targeting-and-enhanced-photodynamic-immunotherapy-of-cancer
#13
Guangbao Yang, Ligeng Xu, Jun Xu, Rui Zhang, Guosheng Song, Yu Chao, Liangzhu Feng, Fengxuan Han, Ziliang Dong, Bin Li, Zhuang Liu
Photodynamic therapy (PDT) is an oxygen-dependent light-triggered noninvasive therapeutic method showing many promising aspects in cancer treatment. For effective PDT, nanoscale carriers are often needed to realize tumor-targeted delivery of photosensitizers, which ideally should further target specific cell organelles that are most vulnerable to reactive oxygen species (ROS). Second, as oxygen is critical for PDT-induced cancer destruction, overcoming hypoxia existing in the majority of solid tumors is important for optimizing PDT efficacy...
April 11, 2018: Nano Letters
https://www.readbyqxmd.com/read/29534020/copper-free-click-chemistry-based-synthesis-and-characterization-of-carbonic-anhydrase-ix-anchored-albumin-paclitaxel-nanoparticles-for-targeting-tumor-hypoxia
#14
Katyayani Tatiparti, Samaresh Sau, Kaustubh A Gawde, Arun K Iyer
Triple negative breast cancer (TNBC) is a difficult to treat disease due to the absence of the three unique receptors estrogen, progesterone and herceptin-2 (HER-2). To improve the current therapy and overcome the resistance of TNBC, there is unmet need to develop an effective targeted therapy. In this regard, one of the logical and economical approaches is to develop a tumor hypoxia-targeting drug formulation platform for selective delivery of payload to the drug-resistant and invasive cell population of TNBC tumors...
March 13, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29515112/hypoxia-induced-matrix-metalloproteinase-13-expression-in-exosomes-from-nasopharyngeal-carcinoma-enhances-metastases
#15
Ying Shan, Bo You, Si Shi, Wei Shi, Zhenxin Zhang, Qicheng Zhang, Miao Gu, Jing Chen, Lili Bao, Dong Liu, Yiwen You
Exosomes are nano-vesicles secreted by tumor cells. Exosomes can transfer complex biological information and induce a diverse signaling response in a wide array of pathological conditions, such as hypoxia. Hypoxia is associated with aggressive phenotypes and poor outcomes in nasopharyngeal carcinoma (NPC) patients. Here, we analyzed the role of exosomes from hypoxic NPC cells in enhancing the metastases of normoxic cells in a hypoxia-induced factor-1α (HIF-1α)-dependent manner. HIF-1α rapidly accumulates and trans-activates hundreds of genes, such as matrix metalloproteinases (MMPs)...
March 7, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29487939/nano-graphene-oxide-manganese-dioxide-nanocomposites-for-overcoming-tumor-hypoxia-and-enhancing-cancer-radioisotope-therapy
#16
Yugui Tao, Longlong Zhu, Yunayuan Zhao, Xuan Yi, Longbao Zhu, Fei Ge, Xiaozhou Mou, Lei Chen, Liang Sun, Kai Yang
While radiotherapy (RT) is commonly used in clinics for cancer treatment, the therapeutic efficiency is not satisfactory owing to the existence of the hypoxic tumor microenvironment which seriously affects the efficiency of RT. Herein, we design polyethylene glycol (PEG)-modified reduced nano-graphene oxide-manganese dioxide (rGO-MnO2 -PEG) nanocomposites to trigger oxygen generation from H2 O2 to reduce the tumor hypoxic microenvironments. We use the radioisotope, 131 I labeled rGO-MnO2 -PEG nanocomposites as therapeutic agents for in vivo tumor radioisotope therapy (RIT), achieving excellent tumor killing and further enhancing the therapeutic efficiency of RIT...
March 15, 2018: Nanoscale
https://www.readbyqxmd.com/read/29327399/poly-lactide-co-glycolide-monomethoxy-poly-polyethylene-glycol-nanoparticles-loaded-with-melatonin-protect-adipose-derived-stem-cells-transplanted-in-infarcted-heart-tissue
#17
Qiang Ma, Junjie Yang, Xu Huang, Weisheng Guo, Sulei Li, Hao Zhou, Jingwei Li, Feng Cao, Yundai Chen
Stem cell transplantation is a promising therapeutic strategy for myocardial infarction. However, transplanted cells face low survival rates due to oxidative stress and the inflammatory microenvironment in ischemic heart tissue. Melatonin has been used as a powerful endogenous antioxidant to protect cells from oxidative injury. However, melatonin cannot play a long-lasting effect against the hostile microenvironment. Nano drug delivery carriers have the ability to protect the loaded drug from degradation in physiological environments in a controlled manner, which results in longer effects and decreased side effects...
April 2018: Stem Cells
https://www.readbyqxmd.com/read/29289560/tumor-control-by-hypoxia-specific-chemotargeting-of-iron-oxide-nanoparticle-berberine-complexes-in-a-mouse-model
#18
S Sreeja, C K Krishnan Nair
AIM: To evaluate the therapeutic efficacy of hypoxic cell-sensitizer Sanazole (SAN) -directed targeting of cytotoxic drug Berberine (BBN) and Iron-oxide nanoparticle (NP) complexes, to solid tumor in Swiss albino mice. MAIN METHODS: NP-BBN-SAN complexes were characterized by FTIR, XRD, TEM and Nano-size analyzer. This complex was orally administered to mice-bearing solid tumor in hind limb. Tumor regression was analysed by measuring tumor volume. Cellular DNA damages were assessed by comet assay...
February 15, 2018: Life Sciences
https://www.readbyqxmd.com/read/29202036/free-radicals-and-advanced-chemistries-involved-in-cell-membrane-organization-influence-oxygen-diffusion-and-pathology-treatment
#19
Richard C Petersen
A breakthrough has been discovered in pathology chemistry related to increasing molecular structure that can interfere with oxygen diffusion through cell membranes. Free radicals can crosslink unsaturated low-viscosity fatty acid oils by chain-growth polymerization into more viscous liquids and even solids. Free radicals are released by mitochondria in response to intermittent hypoxia that can increase membrane molecular organization to reduce fluidity and oxygen diffusion in a possible continuing vicious cycle toward pathological disease...
2017: AIMS Biophysics
https://www.readbyqxmd.com/read/29055990/-neovascularization-aggravated-hepatic-fibrosis-in-combined-hypoxia-nash-rat-model
#20
J Liu, W Wu, D H Gu, C Y Liu, Q Dong, Y L Yao, C S Wang, X P Chen, H X Yang
Objective: To optimize the construction of combined hypoxia NASH rat model on the basis of preliminary work, and to explore the role of neovascularization in the process of hepatic fibrosis. Methods: 32 rats were divided randomly to four groups that were null control group(A group ), hypoxia group(B group), high fat diet group(C group ) and high fat diet plus hypoxia group (D group ),treated with null , Intraperitoneal injection of NaNO(2), high fat diet and high fat diet plus Intraperitoneal injection of NaNO(2) respectively...
July 20, 2017: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
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