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https://www.readbyqxmd.com/read/30102510/tumor-oxygenation-and-hypoxia-inducible-factor-1-functional-inhibition-via-a-reactive-oxygen-species-responsive-nanoplatform-for-enhancing-radiation-therapy-and-abscopal-effects
#1
Lingtong Meng, Yali Cheng, Xiaoning Tong, Shaoju Gan, Yawen Ding, Yu Zhang, Chao Wang, Lei Xu, Yishen Zhu, Jinhui Wu, Yiqiao Hu, Ahu Yuan
Hypoxia, and hypoxia-inducible factor-1 (HIF-1), can induce tumor resistance to radiation therapy. To overcome hypoxia-induced radiation resistance, recent studies have described nano-systems to improve tumor oxygenation for immobilizing DNA damage and simultaneously initiate oxygen-dependent HIF-1α degradation. However, HIF-1α degradation is incomplete during tumor oxygenation treatment alone. Therefore, tumor oxygenation combined with residual HIF-1 functional inhibition is crucial to optimizing therapeutic outcomes of radiotherapy...
August 13, 2018: ACS Nano
https://www.readbyqxmd.com/read/30096565/photosensitizer-crosslinked-in-situ-polymerization-on-catalase-for-tumor-hypoxia-modulation-enhanced-photodynamic-therapy
#2
Hairong Wang, Yu Chao, Jingjing Liu, Wenwen Zhu, Guanglin Wang, Ligeng Xu, Zhuang Liu
Tumor hypoxia is known to be one of critical factors that aggravate the tumor resistance to photodynamic therapy (PDT) in which oxygen is essential for tumor destruction. Herein, catalase, an enzyme to trigger hydrogen peroxide (H2 O2 ) decomposition, is modified by in-situ free radical polymerization, using meso-tetra(p-hydroxyphenyl) porphine (THPP) as the cross-linker to enable condensed grafting of short polyethylene glycol (PEG) chains on the protein surface as a permeable brush-like safeguard. The formulated catalase-entrapped nanocapsules (CAT-THPP-PEG) with enhanced enzyme stability can be labeled with 99m Tc4+ , a radioisotope ion that is chelated by the porphyrin structure of THPP, to allow in vivo single-photon emission computed tomography (SPECT) imaging...
August 4, 2018: Biomaterials
https://www.readbyqxmd.com/read/29967937/conjugation-of-para-benzoquinone-of-cigarette-smoke-with-human-hemoglobin-leads-to-unstable-tetramer-and-reduced-cooperative-oxygen-binding
#3
Amrita Mitra, Amit Kumar Mandal
Besides multiple life-threatening diseases like lung cancer and cardiovascular disease, cigarette smoking is known to produce hypoxia, a state of inadequate oxygen supply to tissues. Hypoxia plays a pivotal role in the development of chronic obstructive pulmonary disease. Smoking during pregnancy imposes risk for the unborn child. In addition to carbon monoxide, conjugation of para-benzoquinone (pBQ), derived from cigarette smoke, with human hemoglobin (HbA) was also reported to contribute in hypoxia. In fact, conjugation of pBQ is more alarming than carbon monoxide as it is an irreversible covalent modification...
July 2, 2018: Journal of the American Society for Mass Spectrometry
https://www.readbyqxmd.com/read/29791792/normalizing-tumor-microenvironment-based-on-photosynthetic-abiotic-biotic-nanoparticles
#4
Diwei Zheng, Bin Li, Lu Xu, Qiu-Ling Zhang, Jin-Xuan Fan, Chu-Xin Li, Xian-Zheng Zhang
Tumor hypoxia has attained the status of a core hallmark of cancer that globally affects the entire tumor phenotype. Reversing tumor hypoxia might offer alternative therapeutic opportunities for current anticancer therapies. In this research, a photosynthetic leaf-inspired abiotic/biotic nano-thylakoid (PLANT) system was designed by fusing the thylakoid membrane with synthetic nanoparticles for efficient O2 generation in vivo. Under 660 nm laser irradiation, the PLANT system exhibited intracellular O2 generation and the anaerobic respiration of the multicellular tumor spheroid was suppressed by PLANT as well...
May 31, 2018: ACS Nano
https://www.readbyqxmd.com/read/29704295/an-assembled-nano-complex-for-improving-both-therapeutic-efficiency-and-treatment-depth-in-photodynamic-therapy
#5
Hongqian Cao, Lei Wang, Yang Yang, Juan Li, Yanfei Qi, Yue Li, Ying Li, Hao Wang, Junbai Li
Photodynamic therapy (PDT) shows unique selectivity and irreversible destruction toward treated tissues or cells, but still has several problems in clinical practice. One is limited therapeutic efficiency, which is attributed to hypoxia in tumor sites. Another is the limited treatment depth because traditional photosensitizes are excited by short wavelength light (<700 nm). An assembled nano-complex system composed of oxygen donor, two-photon absorption (TPA) species, and photosensitizer (PS) was synthesized to address both problems...
April 27, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29688912/tilianin-loaded-reactive-oxygen-species-scavenging-nano-micelles-protect-h9c2-cardiomyocyte-against-hypoxia-reoxygenation-induced-injury
#6
Yanfang Wang, Ying Wang, Xinchun Wang, Ping Hu
Previous studies have shown that tilianin alleviates ischemia-reperfusion-induced cardiomyocyte injury. However, its clinical translation has been hampered because of its insolubility in water. Tilianin-based nano-micelles that may overcome this critical issue are presented. A polyethylene glycol compound was covalently attached to propylene sulfide-formed amphiphilic diblock polymers. In the aqueous solution, tilianin is encapsulated in a hydrophobic shell to form nano-micelles. The Ph-PPS-PEG self-assembled into nanoscale micelles with a size of approximately 70 nm, termed "tilianin-loaded micelles" (TLMs)...
July 2018: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/29565139/smart-nanoreactors-for-ph-responsive-tumor-homing-mitochondria-targeting-and-enhanced-photodynamic-immunotherapy-of-cancer
#7
Guangbao Yang, Ligeng Xu, Jun Xu, Rui Zhang, Guosheng Song, Yu Chao, Liangzhu Feng, Fengxuan Han, Ziliang Dong, Bin Li, Zhuang Liu
Photodynamic therapy (PDT) is an oxygen-dependent light-triggered noninvasive therapeutic method showing many promising aspects in cancer treatment. For effective PDT, nanoscale carriers are often needed to realize tumor-targeted delivery of photosensitizers, which ideally should further target specific cell organelles that are most vulnerable to reactive oxygen species (ROS). Second, as oxygen is critical for PDT-induced cancer destruction, overcoming hypoxia existing in the majority of solid tumors is important for optimizing PDT efficacy...
April 11, 2018: Nano Letters
https://www.readbyqxmd.com/read/29534020/copper-free-click-chemistry-based-synthesis-and-characterization-of-carbonic-anhydrase-ix-anchored-albumin-paclitaxel-nanoparticles-for-targeting-tumor-hypoxia
#8
Katyayani Tatiparti, Samaresh Sau, Kaustubh A Gawde, Arun K Iyer
Triple negative breast cancer (TNBC) is a difficult to treat disease due to the absence of the three unique receptors estrogen, progesterone and herceptin-2 (HER-2). To improve the current therapy and overcome the resistance of TNBC, there is unmet need to develop an effective targeted therapy. In this regard, one of the logical and economical approaches is to develop a tumor hypoxia-targeting drug formulation platform for selective delivery of payload to the drug-resistant and invasive cell population of TNBC tumors...
March 13, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29515112/hypoxia-induced-matrix-metalloproteinase-13-expression-in-exosomes-from-nasopharyngeal-carcinoma-enhances-metastases
#9
Ying Shan, Bo You, Si Shi, Wei Shi, Zhenxin Zhang, Qicheng Zhang, Miao Gu, Jing Chen, Lili Bao, Dong Liu, Yiwen You
Exosomes are nano-vesicles secreted by tumor cells. Exosomes can transfer complex biological information and induce a diverse signaling response in a wide array of pathological conditions, such as hypoxia. Hypoxia is associated with aggressive phenotypes and poor outcomes in nasopharyngeal carcinoma (NPC) patients. Here, we analyzed the role of exosomes from hypoxic NPC cells in enhancing the metastases of normoxic cells in a hypoxia-induced factor-1α (HIF-1α)-dependent manner. HIF-1α rapidly accumulates and trans-activates hundreds of genes, such as matrix metalloproteinases (MMPs)...
March 7, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29487939/nano-graphene-oxide-manganese-dioxide-nanocomposites-for-overcoming-tumor-hypoxia-and-enhancing-cancer-radioisotope-therapy
#10
Yugui Tao, Longlong Zhu, Yunayuan Zhao, Xuan Yi, Longbao Zhu, Fei Ge, Xiaozhou Mou, Lei Chen, Liang Sun, Kai Yang
While radiotherapy (RT) is commonly used in clinics for cancer treatment, the therapeutic efficiency is not satisfactory owing to the existence of the hypoxic tumor microenvironment which seriously affects the efficiency of RT. Herein, we design polyethylene glycol (PEG)-modified reduced nano-graphene oxide-manganese dioxide (rGO-MnO2 -PEG) nanocomposites to trigger oxygen generation from H2 O2 to reduce the tumor hypoxic microenvironments. We use the radioisotope, 131 I labeled rGO-MnO2 -PEG nanocomposites as therapeutic agents for in vivo tumor radioisotope therapy (RIT), achieving excellent tumor killing and further enhancing the therapeutic efficiency of RIT...
March 15, 2018: Nanoscale
https://www.readbyqxmd.com/read/29327399/poly-lactide-co-glycolide-monomethoxy-poly-polyethylene-glycol-nanoparticles-loaded-with-melatonin-protect-adipose-derived-stem-cells-transplanted-in-infarcted-heart-tissue
#11
Qiang Ma, Junjie Yang, Xu Huang, Weisheng Guo, Sulei Li, Hao Zhou, Jingwei Li, Feng Cao, Yundai Chen
Stem cell transplantation is a promising therapeutic strategy for myocardial infarction. However, transplanted cells face low survival rates due to oxidative stress and the inflammatory microenvironment in ischemic heart tissue. Melatonin has been used as a powerful endogenous antioxidant to protect cells from oxidative injury. However, melatonin cannot play a long-lasting effect against the hostile microenvironment. Nano drug delivery carriers have the ability to protect the loaded drug from degradation in physiological environments in a controlled manner, which results in longer effects and decreased side effects...
April 2018: Stem Cells
https://www.readbyqxmd.com/read/29289560/tumor-control-by-hypoxia-specific-chemotargeting-of-iron-oxide-nanoparticle-berberine-complexes-in-a-mouse-model
#12
S Sreeja, C K Krishnan Nair
AIM: To evaluate the therapeutic efficacy of hypoxic cell-sensitizer Sanazole (SAN) -directed targeting of cytotoxic drug Berberine (BBN) and Iron-oxide nanoparticle (NP) complexes, to solid tumor in Swiss albino mice. MAIN METHODS: NP-BBN-SAN complexes were characterized by FTIR, XRD, TEM and Nano-size analyzer. This complex was orally administered to mice-bearing solid tumor in hind limb. Tumor regression was analysed by measuring tumor volume. Cellular DNA damages were assessed by comet assay...
February 15, 2018: Life Sciences
https://www.readbyqxmd.com/read/29202036/free-radicals-and-advanced-chemistries-involved-in-cell-membrane-organization-influence-oxygen-diffusion-and-pathology-treatment
#13
Richard C Petersen
A breakthrough has been discovered in pathology chemistry related to increasing molecular structure that can interfere with oxygen diffusion through cell membranes. Free radicals can crosslink unsaturated low-viscosity fatty acid oils by chain-growth polymerization into more viscous liquids and even solids. Free radicals are released by mitochondria in response to intermittent hypoxia that can increase membrane molecular organization to reduce fluidity and oxygen diffusion in a possible continuing vicious cycle toward pathological disease...
2017: AIMS Biophysics
https://www.readbyqxmd.com/read/29055990/-neovascularization-aggravated-hepatic-fibrosis-in-combined-hypoxia-nash-rat-model
#14
J Liu, W Wu, D H Gu, C Y Liu, Q Dong, Y L Yao, C S Wang, X P Chen, H X Yang
Objective: To optimize the construction of combined hypoxia NASH rat model on the basis of preliminary work, and to explore the role of neovascularization in the process of hepatic fibrosis. Methods: 32 rats were divided randomly to four groups that were null control group(A group ), hypoxia group(B group), high fat diet group(C group ) and high fat diet plus hypoxia group (D group ),treated with null , Intraperitoneal injection of NaNO(2), high fat diet and high fat diet plus Intraperitoneal injection of NaNO(2) respectively...
July 20, 2017: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
https://www.readbyqxmd.com/read/29026068/hollow-mno-2-as-a-tumor-microenvironment-responsive-biodegradable-nano-platform-for-combination-therapy-favoring-antitumor-immune-responses
#15
Guangbao Yang, Ligeng Xu, Yu Chao, Jun Xu, Xiaoqi Sun, Yifan Wu, Rui Peng, Zhuang Liu
Herein, an intelligent biodegradable hollow manganese dioxide (H-MnO2 ) nano-platform is developed for not only tumor microenvironment (TME)-specific imaging and on-demand drug release, but also modulation of hypoxic TME to enhance cancer therapy, resulting in comprehensive effects favoring anti-tumor immune responses. With hollow structures, H-MnO2 nanoshells post modification with polyethylene glycol (PEG) could be co-loaded with a photodynamic agent chlorine e6 (Ce6), and a chemotherapy drug doxorubicin (DOX)...
October 12, 2017: Nature Communications
https://www.readbyqxmd.com/read/28972612/albumin-templated-biomineralizing-growth-of-composite-nanoparticles-as-smart-nano-theranostics-for-enhanced-radiotherapy-of-tumors
#16
Jiawen Chen, Qian Chen, Chao Liang, Zhijuan Yang, Lin Zhang, Xuan Yi, Ziliang Dong, Yu Chao, Youguo Chen, Zhuang Liu
Hypoxia and a dense extracellular matrix within the tumor microenvironment can often lead to the resistance of tumors to radiotherapy. Herein, we use bovine serum albumin (BSA) as a template to induce the growth of both gold (Au) nanoclusters and manganese dioxide (MnO2 ) via biomineralization. In the obtained BSA-Au-MnO2 composite nanoparticles, Au nanoclusters embedded within BSA not only show strong red fluorescence to facilitate imaging, but also act as a radio-sensitizer by absorbing and depositing X-ray energy within tumors to enhance radiotherapy...
October 12, 2017: Nanoscale
https://www.readbyqxmd.com/read/28936174/the-effect-of-velvet-antler-proteins-on-cardiac-microvascular-endothelial-cells-challenged-with-ischemia-hypoxia
#17
Xiang Xiao, Shuqiang Xu, Lin Li, Min Mao, Jinping Wang, Yanjun Li, Ziwei Wang, Fei Ye, Li Huang
Velvet antler (VA) is a precious traditional Chinese medicine that is capable of repeated regeneration. Based on the Chinese medicine theory of coordination the heart and kidneys, VA has been employed to treat heart diseases, including ischemic heart disease, heart failure, and arrhythmia. We examined the effects of VA proteins on primary cardiac microvascular endothelial cells (CMECs) that were subjected to ischemia-hypoxia (IH) to investigate their effects on and mechanism of action in the treatment of ischemic heart disease...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28715447/short-term-alteration-of-biotic-and-abiotic-components-of-the-pelagic-system-in-a-shallow-bay-produced-by-a-strong-natural-hypoxia-event
#18
Eduardo Hernández-Miranda, Rodrigo Veas, Valeria Anabalón, Renato A Quiñones
In January 2008 there was an intensive and extensive upwelling event in the southern Humboldt Current System. This event produced an intrusion of water with low dissolved oxygen into Coliumo Bay, which caused massive mortality and the beaching of pelagic and benthic organisms, including zooplankton. During this event, which lasted 3 to 5 days, we studied and evaluated the effect of the hypoxic water in the bay on the abundance of macrozooplankton, nanoplankton and microphytoplankton, the concentration of several nutrients and hydrographic conditions...
2017: PloS One
https://www.readbyqxmd.com/read/28702620/nanoparticle-delivery-of-curcumin-induces-cellular-hypoxia-and-ros-mediated-apoptosis-via-modulation-of-bcl-2-bax-in-human-neuroblastoma
#19
Irina Kalashnikova, Joseph Mazar, Craig J Neal, Amy L Rosado, Soumen Das, Tamarah J Westmoreland, Sudipta Seal
In this study, several formulations of nanoceria and dextran-nanoceria with curcumin, each demonstrated to have anti-cancer properties, were synthesized and applied as treatment for human childhood neuroblastoma. The anti-cancer activities of these formulations were explored in neuroblastoma models of both MYCN-amplified and non-amplified cell lines. Ceria nanoparticles, coated with dextran and loaded with curcumin, were found to induce substantial cell death in neuroblastoma cells (up to a 2-fold and a 1.6-fold decrease in cell viability for MYCN-upregulated and normal expressing cell lines, respectively; *p < 0...
July 27, 2017: Nanoscale
https://www.readbyqxmd.com/read/28679592/hif-1-mediated-production-of-exosomes-during-hypoxia-is-protective-in-renal-tubular-cells
#20
Wei Zhang, Xiangjun Zhou, Qisheng Yao, Yutao Liu, Hao Zhang, Zheng Dong
Exosomes are nano-sized vesicles produced and secreted by cells to mediate intercellular communication. The production and function of exosomes in kidney tissues and cells remain largely unclear. Hypoxia is a common pathophysiological condition in kidneys. This study was designed to characterize exosome production during hypoxia of rat renal proximal tubular cells (RPTCs), investigate the regulation by hypoxia-inducible factor-1 (HIF-1), and determine the effect of the exosomes on ATP-depletion-induced tubular cell injury...
October 1, 2017: American Journal of Physiology. Renal Physiology
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