Fan Liu, Ting Xu, Jiaxuan He, Yiting Jiang, Linkai Qu, Lei Wang, Jiahui Ma, Qinsi Yang, Wei Wu, Da Sun, Yan Chen
Common tyrosinase (TYR) inhibitors used in cosmetics, such as hydroquinone, kojic acid, and arbutin, can cause side effects including erythema, skin peeling, and dryness. Therefore, the development of natural whitening agents that offer excellent permeability, minimal irritation, and high safety has become a primary focus in the field of TYR inhibitors. In this study, we demonstrate that White birch sap (WBS), within a safe concentration range, effectively reduces TYR activity and melanin content in both B16F10 mouse melanoma cells and zebrafish larvae...
March 15, 2024: Heliyon