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https://www.readbyqxmd.com/read/27879458/the-changing-epidemiology-of-human-t-cell-lymphotropic-virus-type-1-infection-in-peruvian-female-sex-workers-1993-2010
#1
Jenell Stewart, Kristen Heitzinger, Simon Pollett, Martha Calderón, Jorge Alarcón, Thanh G N Ton, Joseph R Zunt
Human T-cell lymphotropic virus type 1 (HTLV-1) was the first human retrovirus to be reported and is associated with neoplastic, neurological, autoimmune, and infectious complications. HTLV-1 is endemic in Peru, with the highest prevalence reported among commercial sex workers. Seroprevalence data collected from Peruvian female sex workers (FSWs) working in Callao over three study periods between 1993 and 2010 were used to examine the secular trend in HTLV-1 prevalence. Between 1993 and 2010, the prevalence of HTLV-1 decreased significantly from 14...
November 22, 2016: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/27795403/the-andes-virus-nucleocapsid-protein-directs-basal-endothelial-cell-permeability-by-activating-rhoa
#2
Elena E Gorbunova, Matthew J Simons, Irina N Gavrilovskaya, Erich R Mackow
: Andes virus (ANDV) predominantly infects microvascular endothelial cells (MECs) and nonlytically causes an acute pulmonary edema termed hantavirus pulmonary syndrome (HPS). In HPS patients, virtually every pulmonary MEC is infected, MECs are enlarged, and infection results in vascular leakage and highly lethal pulmonary edema. We observed that MECs infected with the ANDV hantavirus or expressing the ANDV nucleocapsid (N) protein showed increased size and permeability by activating the Rheb and RhoA GTPases...
October 25, 2016: MBio
https://www.readbyqxmd.com/read/27783711/mechanistic-insight-into-bunyavirus-induced-membrane-fusion-from-structure-function-analyses-of-the-hantavirus-envelope-glycoprotein-gc
#3
Pablo Guardado-Calvo, Eduardo A Bignon, Eva Stettner, Scott Allen Jeffers, Jimena Pérez-Vargas, Gerard Pehau-Arnaudet, M Alejandra Tortorici, Jean-Luc Jestin, Patrick England, Nicole D Tischler, Félix A Rey
Hantaviruses are zoonotic viruses transmitted to humans by persistently infected rodents, giving rise to serious outbreaks of hemorrhagic fever with renal syndrome (HFRS) or of hantavirus pulmonary syndrome (HPS), depending on the virus, which are associated with high case fatality rates. There is only limited knowledge about the organization of the viral particles and in particular, about the hantavirus membrane fusion glycoprotein Gc, the function of which is essential for virus entry. We describe here the X-ray structures of Gc from Hantaan virus, the type species hantavirus and responsible for HFRS, both in its neutral pH, monomeric pre-fusion conformation, and in its acidic pH, trimeric post-fusion form...
October 2016: PLoS Pathogens
https://www.readbyqxmd.com/read/27780263/endocytic-pathways-used-by-andes-virus-to-enter-primary-human-lung-endothelial-cells
#4
Cheng-Feng Chiang, Mike Flint, Jin-Mann S Lin, Christina F Spiropoulou
Andes virus (ANDV) is the major cause of hantavirus pulmonary syndrome (HPS) in South America. Despite a high fatality rate (up to 40%), no vaccines or antiviral therapies are approved to treat ANDV infection. To understand the role of endocytic pathways in ANDV infection, we used 3 complementary approaches to identify cellular factors required for ANDV entry into human lung microvascular endothelial cells. We screened an siRNA library targeting 140 genes involved in membrane trafficking, and identified 55 genes required for ANDV infection...
2016: PloS One
https://www.readbyqxmd.com/read/27621441/host-pathogen-evolutionary-signatures-reveal-dynamics-and-future-invasions-of-vampire-bat-rabies
#5
Daniel G Streicker, Jamie C Winternitz, Dara A Satterfield, Rene Edgar Condori-Condori, Alice Broos, Carlos Tello, Sergio Recuenco, Andrés Velasco-Villa, Sonia Altizer, William Valderrama
Anticipating how epidemics will spread across landscapes requires understanding host dispersal events that are notoriously difficult to measure. Here, we contrast host and virus genetic signatures to resolve the spatiotemporal dynamics underlying geographic expansions of vampire bat rabies virus (VBRV) in Peru. Phylogenetic analysis revealed recent viral spread between populations that, according to extreme geographic structure in maternally inherited host mitochondrial DNA, appeared completely isolated. In contrast, greater population connectivity in biparentally inherited nuclear microsatellites explained the historical limits of invasions, suggesting that dispersing male bats spread VBRV between genetically isolated female populations...
September 27, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27486439/hantavirus-infection-suppresses-thrombospondin-1-expression-in-cultured-endothelial-cells-in-a-strain-specific-manner
#6
Svetlana F Khaiboullina, Sergey P Morzunov, Stephen C St Jeor, Albert A Rizvanov, Vincent C Lombardi
Hantavirus infection is associated with two frequently fatal diseases in humans: Hemorrhagic fever with renal syndrome (HFRS) and hantavirus pulmonary syndrome (HPS). The pathogenesis of hantavirus infection is complex and not fully understood; however, it is believed to involve virus-induced hyperinflammatory immune responses. Thrombospondin-1 (THBS1) is a large homotrimeric protein that plays a putative role in regulating blood homeostasis. Hyperresponsiveness to inflammatory stimuli has also been associated with defects in the THBS1 gene...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27414047/inhibition-of-the-hantavirus-fusion-process-by-predicted-domain-iii-and-stem-peptides-from-glycoprotein-gc
#7
Gonzalo P Barriga, Fernando Villalón-Letelier, Chantal L Márquez, Eduardo A Bignon, Rodrigo Acuña, Breyan H Ross, Octavio Monasterio, Gonzalo A Mardones, Simon E Vidal, Nicole D Tischler
Hantaviruses can cause hantavirus pulmonary syndrome or hemorrhagic fever with renal syndrome in humans. To enter cells, hantaviruses fuse their envelope membrane with host cell membranes. Previously, we have shown that the Gc envelope glycoprotein is the viral fusion protein sharing characteristics with class II fusion proteins. The ectodomain of class II fusion proteins is composed of three domains connected by a stem region to a transmembrane anchor in the viral envelope. These fusion proteins can be inhibited through exogenous fusion protein fragments spanning domain III (DIII) and the stem region...
July 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27300328/atomic-structure-and-biochemical-characterization-of-an-rna-endonuclease-in-the-n-terminus-of-andes-virus-l-protein
#8
Yaiza Fernández-García, Juan Reguera, Carola Busch, Gregor Witte, Oliberto Sánchez-Ramos, Christian Betzel, Stephen Cusack, Stephan Günther, Sophia Reindl
Andes virus (ANDV) is a human-pathogenic hantavirus. Hantaviruses presumably initiate their mRNA synthesis by using cap structures derived from host cell mRNAs, a mechanism called cap-snatching. A signature for a cap-snatching endonuclease is present in the N terminus of hantavirus L proteins. In this study, we aimed to solve the atomic structure of the ANDV endonuclease and characterize its biochemical features. However, the wild-type protein was refractory to expression in Escherichia coli, presumably due to toxic enzyme activity...
June 2016: PLoS Pathogens
https://www.readbyqxmd.com/read/27233645/effect-of-vandetanib-on-andes-virus-survival-in-the-hamster-model-of-hantavirus-pulmonary-syndrome
#9
Brian H Bird, Punya Shrivastava-Ranjan, Kimberly A Dodd, Bobbie R Erickson, Christina F Spiropoulou
Hantavirus pulmonary syndrome (HPS) is a severe disease caused by hantavirus infection of pulmonary microvascular endothelial cells leading to microvascular leakage, pulmonary edema, pleural effusion and high case fatality. Previously, we demonstrated that Andes virus (ANDV) infection caused up-regulation of vascular endothelial growth factor (VEGF) and concomitant downregulation of the cellular adhesion molecule VE-cadherin leading to increased permeability. Analyses of human HPS-patient sera have further demonstrated increased circulating levels of VEGF...
August 2016: Antiviral Research
https://www.readbyqxmd.com/read/27099308/depletion-of-alveolar-macrophages-does-not-prevent-hantavirus-disease-pathogenesis-in-golden-syrian-hamsters
#10
Christopher D Hammerbeck, Rebecca L Brocato, Todd M Bell, Christopher W Schellhase, Steven R Mraz, Laurie A Queen, Jay W Hooper
UNLABELLED: Andes virus (ANDV) is associated with a lethal vascular leak syndrome in humans termed hantavirus pulmonary syndrome (HPS). The mechanism for the massive vascular leakage associated with HPS is poorly understood; however, dysregulation of components of the immune response is often suggested as a possible cause. Alveolar macrophages are found in the alveoli of the lung and represent the first line of defense to many airborne pathogens. To determine whether alveolar macrophages play a role in HPS pathogenesis, alveolar macrophages were depleted in an adult rodent model of HPS that closely resembles human HPS...
July 15, 2016: Journal of Virology
https://www.readbyqxmd.com/read/26982467/genome-sequence-of-a%C3%A2-divergent-colombian-isolate-of-potato-virus-v%C3%A2-pvv-infecting-solanum-phureja
#11
P Gutiérrez, H Jaramillo Mesa, M Marín Montoya
Deep sequencing analysis of the transcriptome of a Solanum phureja cv. Criolla Colombia plant with symptoms typical of a virus disease revealed an infection with potato virus V (PVV). The PVV-phureja genome comprises 9904 nt, exhibits 83% nucleotide identity with currently fully sequenced PVV isolates and contains one large ORF that codes for a polyprotein of 3065 residues flanked by 5' and 3' UTR of 217 and 448 nt, respectively. Phylogenetic analysis of the PVV-phureja polyprotein indicates that it is divergent with respect to most PVV isolates...
March 2016: Acta Virologica
https://www.readbyqxmd.com/read/26907493/andes-hantavirus-infection-of-a-3d-human-lung-tissue-model-reveals-a-late-peak-in-progeny-virus-production-followed-by-increased-levels-of-proinflammatory-cytokines-and-vegf-a
#12
Karin B Sundström, Anh Thu Nguyen Hoang, Shawon Gupta, Clas Ahlm, Mattias Svensson, Jonas Klingström
Andes virus (ANDV) causes hantavirus pulmonary syndrome (HPS), a severe acute disease with a 40% case fatality rate. Humans are infected via inhalation, and the lungs are severely affected during HPS, but little is known regarding the effects of ANDV-infection of the lung. Using a 3-dimensional air-exposed organotypic human lung tissue model, we analyzed progeny virus production and cytokine-responses after ANDV-infection. After a 7-10 day period of low progeny virus production, a sudden peak in progeny virus levels was observed during approximately one week...
2016: PloS One
https://www.readbyqxmd.com/read/26826986/-hantavirus-pulmonary-syndrome-in-buenos-aires-2009-2014
#13
Ayelén A Iglesias, Carla M Bellomo, Valeria P Martínez
Andes virus is the causative agent of hantavirus pulmonary syndrome (HPS) in Argentina and neighboring countries. In our country four different areas are affected: Northwest, Southwest, Central and Northeast, where distinct Andes virus genotypes were characterized. Three genotypes were described in Buenos Aires province (Central area): AND-Buenos Aires, AND-Lechiguanas and AND-Plata. In this work, we considered all HPS cases confirmed by ELISA and real time RT-PCR during the period 2009-2014 in Buenos Aires province...
2016: Medicina
https://www.readbyqxmd.com/read/26726999/co-infection-by-chytrid-fungus-and-ranaviruses-in-wild-and-harvested-frogs-in-the-tropical-andes
#14
Robin W Warne, Brandon LaBumbard, Seth LaGrange, Vance T Vredenburg, Alessandro Catenazzi
While global amphibian declines are associated with the spread of Batrachochytrium dendrobatidis (Bd), undetected concurrent co-infection by other pathogens may be little recognized threats to amphibians. Emerging viruses in the genus Ranavirus (Rv) also cause die-offs of amphibians and other ectotherms, but the extent of their distribution globally, or how co-infections with Bd impact amphibians are poorly understood. We provide the first report of Bd and Rv co-infection in South America, and the first report of Rv infections in the amphibian biodiversity hotspot of the Peruvian Andes, where Bd is associated with extinctions...
2016: PloS One
https://www.readbyqxmd.com/read/26611971/association-of-vectors-and-environmental-conditions-during-the-emergence-of-peruvian-horse-sickness-orbivirus-and-yunnan-orbivirus-in-northern-peru
#15
María R Méndez-López, Houssam Attoui, David Florin, Charles H Calisher, J Christian Florian-Carrillo, Stephanie Montero
Since 1983, cases of diseased donkeys and horses with symptoms similar to those produced by alphaviruses were identified in two departments in northern Peru; however serological testing ruled out the presence of those viruses and attempts to isolate an agent were also unproductive. In 1997, also in northern Peru, two new orbiviruses were discovered, each recognized as a causative agent of neurological diseases in livestock and domestic animals and, at the same time, mosquitoes were found to be infected with these viruses...
December 2015: Journal of Vector Ecology: Journal of the Society for Vector Ecology
https://www.readbyqxmd.com/read/26559827/crystal-structure-of-the-core-region-of-hantavirus-nucleocapsid-protein-reveals-the-mechanism-for-ribonucleoprotein-complex-formation
#16
Yu Guo, Wenming Wang, Yuna Sun, Chao Ma, Xu Wang, Xin Wang, Pi Liu, Shu Shen, Baobin Li, Jianping Lin, Fei Deng, Hualin Wang, Zhiyong Lou
UNLABELLED: Hantaviruses, which belong to the genus Hantavirus in the family Bunyaviridae, infect mammals, including humans, causing either hemorrhagic fever with renal syndrome (HFRS) or hantavirus cardiopulmonary syndrome (HCPS) in humans with high mortality. Hantavirus encodes a nucleocapsid protein (NP) to encapsidate the genome and form a ribonucleoprotein complex (RNP) together with viral polymerase. Here, we report the crystal structure of the core domains of NP (NPcore) encoded by Sin Nombre virus (SNV) and Andes virus (ANDV), which are two representative members that cause HCPS in the New World...
January 2016: Journal of Virology
https://www.readbyqxmd.com/read/26374989/expression-and-purification-of-the-surface-proteins-from-andes-virus
#17
Camila E Beltrán-Ortiz, Maria F Starck-Mendez, Yaiza Fernández, Omar Farnós, Eddy E González, Coralia I Rivas, F Camacho, Felipe A Zuñiga, Jorge R Toledo, Oliberto Sánchez
Andes virus is the main causative agent of Hantavirus cardiopulmonary syndrome in South America. There are currently no vaccines or treatments against Andes virus. However, there are several evidences suggesting that antibodies against Andes virus envelope glycoproteins may be enough to confer full protection against Hantavirus cardiopulmonary syndrome. The goal of the present work was to express, purify and characterize the extracellular domains of Andes virus glycoproteins Gn and Gc. We generated two adenoviral vectors encoding the extracellular domains of Andes virus glycoproteins Gn and Gc...
September 12, 2015: Protein Expression and Purification
https://www.readbyqxmd.com/read/26310672/acidification-triggers-andes-hantavirus-membrane-fusion-and-rearrangement-of-gc-into-a-stable-post-fusion-homotrimer
#18
Rodrigo Acuña, Eduardo A Bignon, Roberta Mancini, Pierre-Yves Lozach, Nicole D Tischler
The hantavirus membrane fusion process is mediated by the Gc envelope glycoprotein from within endosomes. However, little is known about the specific mechanism that triggers Gc fusion activation, and its pre- and post-fusion conformations. We established cell-free in vitro systems to characterize hantavirus fusion activation. Low pH was sufficient to trigger the interaction of virus-like particles with liposomes. This interaction was dependent on a pre-fusion glycoprotein arrangement. Further, low pH induced Gc multimerization changes leading to non-reversible Gc homotrimers...
November 2015: Journal of General Virology
https://www.readbyqxmd.com/read/26220480/detection-of-different-south-american-hantaviruses
#19
Alexandro Guterres, Renata Carvalho de Oliveira, Jorlan Fernandes, Carlos Guerra Schrago, Elba Regina Sampaio de Lemos
Hantaviruses are the etiologic agents of Hemorrhagic Fever with Renal Syndrome (HFRS) in Old World, and Hantavirus Pulmonary Syndrome (HPS)/Hantavirus Cardiopulmonary Syndrome (HCPS), in the New World. Serological methods are the most common approach used for laboratory diagnosis of HCPS, however theses methods do not allow the characterization of viral genotypes. The polymerase chain reaction (PCR) has been extensively used for diagnosis of viral infections, including those caused by hantaviruses, enabling detection of few target sequence copies in the sample...
December 2, 2015: Virus Research
https://www.readbyqxmd.com/read/26126854/haploid-genetic-screen-reveals-a-profound-and-direct-dependence-on-cholesterol-for-hantavirus-membrane-fusion
#20
Lara M Kleinfelter, Rohit K Jangra, Lucas T Jae, Andrew S Herbert, Eva Mittler, Katie M Stiles, Ariel S Wirchnianski, Margaret Kielian, Thijn R Brummelkamp, John M Dye, Kartik Chandran
UNLABELLED: Hantaviruses cause hemorrhagic fever with renal syndrome (HFRS) in the Old World and a highly fatal hantavirus cardiopulmonary syndrome (HCPS) in the New World. No vaccines or antiviral therapies are currently available to prevent or treat hantavirus disease, and gaps in our understanding of how hantaviruses enter cells challenge the search for therapeutics. We performed a haploid genetic screen in human cells to identify host factors required for entry by Andes virus, a highly virulent New World hantavirus...
2015: MBio
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