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topiramate in migraine

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https://www.readbyqxmd.com/read/30455137/evaluation-of-cognitive-functions-in-migraineurs-treated-with-topiramate
#1
Bilgin Öztürk, Akçay Övünç Özön, Ömer Karadaş
Topiramate for the treatment of migraine prophylaxis may cause side effects such as cognitive dysfunction. We aimed to investigate the topiramate's efficacy in migraineours and effect on cognitive functions. 24 migraine patients (Group 1) and 24 healthy participants (Group 2) were included. In both groups event-related potentials P300 Latency, Amplitude and N200 Latency, Amplitude's were evaluated. Topiramate treatment was ordered to group 1. Two months after treatment, the same parameters were evaluated. Monthly number of attacks, painful days, analgesic-triptan use and VAS scores were compared before and 2 months after treatment...
November 16, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/30319425/age-dependent-anti-migraine-effects-of-valproic-acid-and-topiramate-in-rats
#2
Pokai Huang, Ping-Hung Kuo, Ming Tatt Lee, Lih-Chu Chiou, Pi-Chuan Fan
Background: Valproic acid (VPA) and topiramate (TPM), initially developed as antiepileptics, are approved for migraine prophylaxis in adults but not children. The differences in their antimigraine mechanism(s) by age remain unclear. Methods: A migraine model induced by intra-cisternal ( i.c. ) capsaicin instillation in pediatric (4-5 weeks) and adult (8-9 weeks) rats was pretreated with VPA (30, 100 mg/kg) or TPM (10, 30, 100 mg/kg). Noxious meningeal stimulation by the irritant capsaicin triggered trigeminovascular system (TGVS) activation mimicking migraine condition, which were assessed peripherally by the depletion of calcitonin gene-related peptide (CGRP) in sensory nerve fibers of the dura mater, the increased CGRP immunoreactivity at trigeminal ganglia (TG) and centrally by the number of c-Fos-immunoreactive (c-Fos-ir) neurons in the trigeminocervical complex (TCC)...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/30316628/topically-applied-linoleic-linolenic-acid-for-chronic-migraine
#3
Clarissa Santos, Donald F Weaver
The topical application of linoleic and linolenic acids is a potential prophylactic approach to migraine via an anti-inflammatory mechanism. We present a 45-year-old woman with chronic migraine without aura. Previous use of abortive or prophylactic therapies including sumatriptan, amitriptyline and topiramate had failed due to lack of efficacy or side-effects, especially vomiting. In search of a topical agent she performed an n-of-1 trial comparing application of linoleic acid (safflower oil) versus oleic acid (olive oil) for migraine relief...
October 10, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/30304907/clinical-manifestations-of-headache-in-children-younger-than-7-years
#4
Bu Seon Kang, Jinsun Lee, Jin Hyuk Choi, Hyeok Hee Kwon, Joon Won Kang
PURPOSE: Headache is a common symptom during childhood. It is usually persistent and requires special care. This study aimed to identify the characteristics of headache in children <7 years of age. METHODS: We reviewed 3 years of clinical files on children <7 years of age with a chief complaint of headache. RESULTS: This study included 146 children (66 males, 80 females; mean age, 5.5±1.0 years). Mean symptom duration was 5.8±7.9 months...
November 2018: Korean Journal of Pediatrics
https://www.readbyqxmd.com/read/30304742/vestibular-migraine-with-visual-aura-and-olfactory-hallucination-in-children-two-case-reports
#5
L M Agessi, T R Villa
BACKGROUND:  Approximately 3.9% children with migraine have olfactory hallucination which was defined as a perception of a smell without the substantial existence of any physical odor. CASE:  We described the first two cases of children with vestibular migraine, presenting visual aura and olfactory hallucination. ​ We reported two children with vertigo, visual aura, and olfactory hallucination before the headache who were responsive to topiramate. CONCLUSION:  The clinical description of olfactory hallucination presented some characteristics of migraine aura...
December 2018: Neuropediatrics
https://www.readbyqxmd.com/read/30231626/benefit-risk-assessment-of-erenumab-and-current-migraine-prophylactic-treatments-using-the-likelihood-of-being-helped-or-harmed
#6
Pamela Vo, Shihua Wen, Marie-Josée Martel, Dimos Mitsikostas, Uwe Reuter, Jan Klatt
Objective This study evaluated the benefit-risk profile of erenumab relative to other therapies approved for migraine prophylaxis and available in the majority of European countries. Methods Trials were identified via a published systematic literature review updated to December 2017 using MEDLINE. Erenumab's pivotal trials study reports were also included (NCT02066415, NCT02456740). From these sources, ≥ 50% responder rates and discontinuations due to adverse events were extracted to generate numbers needed to treat and harm and likelihood of being helped or harmed, a quantitative benefit-risk measure...
September 19, 2018: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/30152162/horizontal-direction-changing-positional-nystagmus-and-vertigo-a-case-of-vestibular-migraine-masquerading-as-horizontal-canal-bppv
#7
Shin C Beh
Episodic positional vertigo is typically due to benign paroxysmal positional vertigo (BPPV) but may also be a manifestation of vestibular migraine. Distinguishing vestibular migraine from BPPV is essential since the treatment of each disorder is markedly different. The 31-month clinical course of a 41-year-old woman with vestibular migraine causing recurrent positional vertigo is described. During vestibular migraine attacks, she developed left-beating nystagmus in the upright position with removal of fixation, and geotropic horizontal nystagmus during the supine roll test...
July 2018: Headache
https://www.readbyqxmd.com/read/30137671/pharmacologic-prevention-of-migraine-a-narrative-review-of-the-state-of-the-art-in-2018
#8
REVIEW
Elizabeth Loder, Paul Rizzoli
This paper describes current non-antibody pharmacologic approaches to the prevention of migraine in adults. Preventive therapy should be considered for patients with migraine who routinely have more than 6 headache days per month or in other special circumstances. Choices for preventive therapy are based on patient preferences about side effects and evidence of efficacy. The evidence level and commonly used doses for selected categories of migraine preventive medication are reviewed, including antiepileptic drugs, antihypertensive drugs, and antidepressants...
August 23, 2018: Headache
https://www.readbyqxmd.com/read/30136603/real-world-assessment-of-treatment-with-extended-release-topiramate-trokendi-xr-%C3%A2-and-comparison-with-previous-immediate-release-topiramate-treatment
#9
Welton O'Neal, Elizabeth E Hur, Tesfaye Liranso, Barry Patel
AIM: Examine clinical profile of extended-release topiramate (Trokendi XR® ) and compare treatment-emergent adverse events (TEAEs) associated with Trokendi XR versus previous immediate-release topiramate (TPM-IR) treatment. PATIENTS & METHODS: Pilot retrospective study analyzing data extracted from medical charts of patients ≥6 years of age prescribed Trokendi XR. RESULTS: Trokendi XR was the most commonly used to prevent migraine...
August 23, 2018: Journal of Comparative Effectiveness Research
https://www.readbyqxmd.com/read/30127167/topiramate-induced-acute-angle-closure-with-severe-panuveitis-a-challenging-case-report
#10
Padmamalini Mahendradas, Snehanka Parab, Rajesh Sasikumar, Ankush Kawali, Bhujang K Shetty
A 36-year-old female presented with the complaints of pain, photophobia, redness, and sudden diminution of vision in both the eyes following topiramate for migraine treatment. On examination, there was panuveitis with angle-closure glaucoma in both the eyes with fibrinous exudate with pigments in the anterior chamber of the left eye. B scan revealed increased choroidal thickness in both the eyes. Serial anterior segment optical coherence tomography scans were done in the left eye to demonstrate the gradual resolution of the fibrin material from the anterior chamber...
September 2018: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/30099954/a-case-report-of-isolated-orbital-vasculitis-mimicking-retinal-migraine-a-potential-cause-of-recurrent-transient-monocular-blindness-and-ipsilateral-headache
#11
Ji-Hyung Park, Kyung-Ah Park, Jihoon Cha, Sung Tae Kim, Chin-Sang Chung, Mi Ji Lee
Background Retinal migraine is an important differential diagnosis of recurrent transient monocular blindness accompanied by headache when other etiologies are excluded. Here, we report a case of orbital vasculitis which initially mimicked retinal migraine. Case report A 47-year-old woman had recurrent episodes of fully reversible transient monocular blindness accompanied by ipsilateral headache for 15 months. The patient's neuroimaging and cardiac and ophthalmologic evaluations were normal. With a diagnosis of retinal migraine, her symptoms remitted in response to prophylactic treatment with topiramate and propranolol for 8 months...
August 12, 2018: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/30094042/case-report-the-role-of-oct-in-examination-of-a-patient-with-topiramate-induced-acute-angle-closure-acute-myopia-and-macular-striae
#12
Matías Osaba, Víctor Eduardo Reviglio
This work reports on a clinical case of a female who presented with headache, bilateral eye pain and vision loss. Intraocular pressures were 40 mm Hg in the right eye and 45 mm Hg in the left eye. Optical Coherence Tomography examination shows the iridocorneal angle was collapsed and macular striae were also observed. The patient had been on topiramate due to migraines 7 days before presentation. Diagnosis for topiramate-induced acute angle closure was made in both eyes. The patient showed improvement in symptoms a few days after treatment initiation and images confirmed that the iridocorneal angle had been enlarged and macular striae had disappeared...
July 2018: Oxford Medical Case Reports
https://www.readbyqxmd.com/read/30079481/effects-of-systemic-inhibitors-of-acid-sensing-ion-channels-1-asic1-against-acute-and-chronic-mechanical-allodynia-in-a-rodent-model-of-migraine
#13
Clément Verkest, Emilie Piquet, Sylvie Diochot, Mélodie Dauvois, Michel Lanteri-Minet, Eric Lingueglia, Anne Baron
BACKGROUND AND PURPOSE: Acid-sensing ion channels (ASICs) are neuronal proton sensors emerging as potential therapeutic targets in pain of the orofacial region. Amiloride, a non-specific ASIC blocker, has been shown to exert beneficial effects in animal models of migraine and in patients. We explored the involvement of the ASIC1-subtype in cutaneous allodynia, a hallmark of migraine affecting cephalic and extra-cephalic regions in about 70% of migrainers. EXPERIMENTAL APPROACH: We investigated the effects of systemic injections of amiloride and mambalgin-1, a specific inhibitor of ASIC1a- and ASIC1b-containing channels, on cephalic and extra-cephalic mechanical sensitivity in a rodent model of acute and chronic migraine induced by i...
November 2018: British Journal of Pharmacology
https://www.readbyqxmd.com/read/30074549/preventive-therapy-of-migraine
#14
Todd J Schwedt
PURPOSE OF REVIEW: This article reviews the preventive therapy of migraine, including indications, strategies for use, and available treatments. RECENT FINDINGS: Lifestyle modifications and migraine trigger avoidance are recommended as preventive measures for all individuals with migraine. The decision to recommend additional migraine preventive therapy should consider the frequency of migraine attacks and headaches, extent of migraine-associated disability, frequency of using acute migraine treatments and the responsiveness to such treatments, and patient preferences...
August 2018: Continuum: Lifelong Learning in Neurology
https://www.readbyqxmd.com/read/30073584/refining-the-benefit-risk-profile-of-anti-epileptic-drugs-in-headache-disorders
#15
REVIEW
Michael J Marmura, Aliza S Kumpinsky
Anti-epileptic drugs are among the most effective drugs for migraine prophylaxis, and will likely continue to have a role even as new therapies emerge. Topiramate and valproate are effective for the preventive treatment of migraine, and other medications such as gabapentin or lamotrigine may have a role in the treatment of those with allodynia or frequent aura, respectively. Oxcarbazepine, carbamazepine, phenytoin, gabapentin, and others may alleviate pain in trigeminal neuralgia. While many anti-epileptic drugs can be effective in those with migraine or other headaches, most of these agents can potentially cause serious side effects...
August 2018: CNS Drugs
https://www.readbyqxmd.com/read/30073201/loss-of-blood-brain-barrier-integrity-in-a-kcl-induced-model-of-episodic-headache-enhances-cns-drug-delivery
#16
Karissa E Cottier, Emily A Galloway, Elisa C Calabrese, Margaret E Tome, Erika Liktor-Busa, John Kim, Thomas P Davis, Todd W Vanderah, Tally M Largent-Milnes
Cortical spreading depression (CSD) in the CNS is suggested as a common mechanism contributing to headache. Despite strong evidence for CNS involvement in headache disorders, drug development for headache disorders remains focused on peripheral targets. Difficulty in delivering drugs across the blood-brain barrier (BBB) may partially account for this disparity. It is known, however, that BBB permeability is increased during several CNS pathologies. In this study, we investigated BBB changes in response to KCl-induced CSD events and subsequent allodynia in rats...
July 2018: ENeuro
https://www.readbyqxmd.com/read/30019592/cluster-status-migrainosus-with-a-weekly-periodicity-responsive-to-high-flow-oxygen-a-case-report
#17
Susan M Seav, Nathaniel M Schuster
Background There are cases in the headache literature described as "cluster-migraine," but none of stereotyped cases of cluster headache evolving into status migrainosus. We believe this is the first documented case of "cluster-status migrainosus". Case A 54 year-old female hospital administrator presented with headaches with a unique periodicity and semiology that were acutely responsive to high-flow oxygen. She experienced cluster headache attacks every Thursday morning at 3-4 am, which would evolve into status migrainosus lasting through Sunday evening...
January 1, 2018: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/30016665/the-%C3%AE-6-subunit-containing-gaba-a-receptor-a-novel-drug-target-for-inhibition-of-trigeminal-activation
#18
Pi-Chuan Fan, Tzu-Hsuan Lai, Chia Chun Hor, Ming Tatt Lee, Pokai Huang, Werner Sieghart, Margot Ernst, Daniel E Knutson, James Cook, Lih-Chu Chiou
Novel treatments against migraine are an urgent medical requirement. The α6 subunit-containing GABAA receptors (α6GABAA Rs) are expressed in trigeminal ganglia (TG), the hub of the trigeminal vascular system (TGVS) that is involved in the pathogenesis of migraine. Here we reveal an unprecedented role of α6GABAA Rs in ameliorating TGVS activation using several pharmacological approaches in an animal model mimicking pathological changes in migraine. TGVS activation was induced by intra-cisternal (i.c.) instillation of capsaicin in Wistar rats...
September 15, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/30003352/chronic-and-intermittent-administration-of-systemic-nitroglycerin-in-the-rat-induces-an-increase-in-the-gene-expression-of-cgrp-in-central-areas-potential-contribution-to-pain-processing
#19
Rosaria Greco, Chiara Demartini, Anna Maria Zanaboni, Cristina Tassorelli
BACKGROUND: Calcitonin gene related peptide (CGRP) is a key neuropeptide involved in the activation of the trigeminovascular system and it is likely related to migraine chronification. Here, we investigated the role of CGRP in an animal model that mimics the chronic migraine condition via repeated and intermittent nitroglycerin (NTG) administration. We also evaluated the modulatory effect of topiramate on this experimental paradigm. Male Sprague-Dawley rats were injected with NTG (5 mg/kg, i...
July 13, 2018: Journal of Headache and Pain
https://www.readbyqxmd.com/read/29955552/combination-of-venlafaxine-and-phentermine-topiramate-induced-psychosis-a-case-report
#20
Jaclyn Homola, Robin Hieber
Background: Various publications have noted increases in dopamine, specifically in the mesolimbic region of the brain, to have a direct correlation to psychotic-like symptoms. Venlafaxine, a first-line medication for depression, inhibits the reuptake of both serotonin and norepinephrine. Additionally, venlafaxine weakly inhibits the reuptake of dopamine. Phentermine/topiramate (Qsymia®), specifically the phentermine component, functions by blocking the dopamine and norepinephrine transporter, similar to amphetamine...
March 2018: The mental health clinician
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