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Delphine Charvin, Rossella Medori, Robert A Hauser, Olivier Rascol
This corrects the article DOI: 10.1038/nrd.2018.136.
October 12, 2018: Nature Reviews. Drug Discovery
Saman Setareh-Shenas, Felix Thomas, Robert M Cole, Alejandro Lemor, Eyal Herzog, Francisco Arabia, Jaime Moriguchi
Ventricular assist device (VAD) implantation has improved quality of life and short-term survival for advanced heart failure patients. There are limited data from single-center studies addressing the characteristics and etiologies of 30 day readmissions after VAD implant. We used the Nationwide Readmissions Database (NRD) 2014 to identify insertion of implantable heart assist system during index admission. Primary and secondary outcomes were 30 day readmissions and leading etiologies, respectively. We analyzed 1,481 patients who received VAD during the primary admission of whom 1,315 patients survived to hospital discharge (mortality rate 11...
October 3, 2018: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
Jonathan J Cui, Raj J Gala, Nathaniel T Ondeck, Ryan P McLynn, Patawut Bovonratwet, Blake Shultz, Jonathan N Grauer
BACKGROUND CONTEXT: Posterior lumbar fusion (PLF) is a commonly performed procedure. The evolution of bundled payment plans is beginning to require physicians to more closely consider patient outcomes up to 90 days after an operation. Current quality metrics and other databases often consider only 30 postoperative days. The relatively new Healthcare Cost and Utilization Project National Readmissions Database (HCUP-NRD) tracks patient-linked hospital admissions data for up to one calendar year...
September 13, 2018: Spine Journal: Official Journal of the North American Spine Society
Khalid Mumtaz, Abdulfatah Issak, Kyle Porter, Sean Kelly, James Hanje, Anthony J Michaels, Lanla F Conteh, Ashraf El-Hinnawi, Sylvester M Black, Marwan S Abougergi
INTRODUCTION: The early readmission in patients with decompensated liver cirrhosis leads to enormous burden on healthcare utilization. METHODS: Retrospective cohort study using the 2013 and 2014 Nationwide Readmission Database (NRD) was conducted. Patients with diagnoses of cirrhosis and at least one feature of decompensation were included. The primary outcome was to develop a validated risk model for early readmission. Secondary outcomes were to study 30-day all cause-readmission rate and most common reasons for readmission...
September 15, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
Turner Osler, Dekang Yuan, Jeremy Holden, Zihao Huang, Alan Cook, Laurent G Glance, Jeffrey S Buzas, David W Hosmer
INTRODUCTION: Readmission following hospital discharge is both common and costly. The Hospital Readmission Reduction Program (HRRP) financially penalizes hospitals for readmission following admission for some conditions, but this approach may not be appropriate for all conditions. We wished to determine if hospitals differed in their adjusted readmission rates following an index hospital admission for traumatic injury. PATIENTS AND METHODS: We extracted from the AHRQ National Readmission Dataset (NRD) all non-elderly adult patients hospitalized following traumatic injury in 2014...
August 27, 2018: Injury
Vincenzo Di Marzo
This corrects the article DOI: 10.1038/nrd.2018.115.
August 30, 2018: Nature Reviews. Drug Discovery
Purav Shah, Shilpkumar Arora, Varun Kumar, Surina Sharma, Harshil Shah, Byomesh Tripathi, Purnima Sharma, Ravina Sharma, Sejal Savani, Muhammad Raheel Qureshi, Ibrahim Faruqi
BACKGROUND: Pulmonary embolism (PE) is associated with significant morbidity and mortality in hospitalized patients. Real time data on 90-day mortality, bleeding, and readmission is sparse. METHODS: The study cohort was derived from the National Readmission Data (NRD) 2013 to 2014. PE was identified using International Classification of Diseases, ninth Revision (ICD-9-CM) code 415.11/3/9 in the primary diagnosis field. Any admission within 90 days of primary admission was considered a 90-day readmission...
September 2018: Clinical Cardiology
Matthew S J Mangan, Edward J Olhava, William R Roush, H Martin Seidel, Gary D Glick, Eicke Latz
This corrects the article DOI: 10.1038/nrd.2018.97.
September 2018: Nature Reviews. Drug Discovery
Rennier Martinez, Lukas Gaffney, Joshua Parreco, Marcus Eby, Aaron Hayson, Elie Donath, Mehdi Bathaii, Michael Finch, Jack Zeltzer
BACKGROUND: Hospital readmissions are tied to financial penalties and thus significantly influence health-care policy. Many current studies on readmissions lack national representation by not tracking readmissions across hospitals. The recently released Nationwide Readmission Database is one of the most comprehensive national sources of readmission data available, making it an invaluable resource to understand this critically important health policy issue. METHODS: The Nationwide Readmission Database for 2013 and 2014 was queried for adult patients with abdominal aortic aneurysm (441...
August 7, 2018: Annals of Vascular Surgery
Tingting Qin, Yanxiao Zhang, Katie R Zarins, Tamara R Jones, Shama Virani, Lisa A Peterson, Jonathan B McHugh, Douglas Chepeha, Gregory T Wolf, Laura S Rozek, Maureen A Sartor
While whole-exome DNA sequencing is the most common technology to study genetic variants in tumors in known exonic regions, RNA-seq is cheaper, covers most of the same exonic regions, and is often more readily available. In this study, we show the utility of mRNA-seq-based variant analysis combined with targeted gene sequencing performed on both tumor and matched blood as an alternative when exome data is unavailable. We use the approach to study expressed variant profiles in the well-characterized University of Michigan (UM) head and neck squamous carcinoma (HNSCC) cohort (n = 36)...
July 30, 2018: Scientific Reports
Nancy Maldonado, Joaquin Michel, Kelly Barnes
INTRODUCTION: Reducing hospital readmissions is a growing priority for hospitals and clinicians in their efforts to improve quality of care and curtail costs. Augmentation cystoplasty is among the most complex and high-morbidity operations in pediatric urology, with up to 25% of patients experiencing a postoperative complication. However, there is a paucity of literature addressing the incidence and characteristics of hospital readmissions after these procedures. This information may be useful in tailoring perioperative interventions to reduce rehospitalization in this population...
July 4, 2018: Journal of Pediatric Urology
Qianping Chen, Lili He, Changming Mo, Zhifeng Zhang, Hairong Long, Xiaoyu Gu, Ying Wei
Resina Draconis is a highly valued traditional medicine widely used in Arabia since ancient times, and it has been commonly used as an antidiarrheic, antimicrobial, antiulcer, blood circulation promoter as well as an anti-inflammatory agent. The tree source from which this medicine orignates grows extremely slowly, producing a very low yield of Resina Draconis. To meet the increasing market demand, artificial methods for stimulating Resina Draconis formation have been developed and applied. However, the chemical differences between artificially induced Resina Draconis ( AIRD ) and natural Resina Draconis ( NRD ) have been rarely studied...
July 25, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Lin Lin, Lili Guan, Weiliang Wu, Rongchang Chen
OBJECTIVES: To assess the correlation between surface respiratory electromyography(sEMG) and esophageal diaphragm electromyography(EMGdi) at different levels of neural respiratory drive (NRD). DESIGN: Randomised parallel design controlled trial. SETTING: The First Affiliated Hospital of Guangzhou Medical University. PARTICIPANTS: 15 healthy subjects and 1 severe to very severe stable COPD patients were studied. INTERVENTIONS: 15 healthy subjects performed incremental inspiratory threshold loading (ILT) and 15 stable COPD patients underwent noninvasive positive pressure ventilation (NPPV)...
July 21, 2018: Respiratory Physiology & Neurobiology
Eliza W Beal, Fabio Bagante, Anghela Paredes, Qinyu Chen, Ozgur Akgul, Katiuscha Merath, Mary E Dillhoff, Jordan M Cloyd, Timothy M Pawlik
INTRODUCTION: The Center for Medicare and Medicaid Services (CMS) has identified readmission as an important quality metric. With an increased emphasis on regionalization of complex hepato-pancreato-biliary (HPB) surgery to high-volume centers, care of readmitted HPB patients may be fragmented if readmission occurs at a non-index hospital. We sought to define the proportion of HPB readmissions, as well as evaluate outcomes, that occur at an index versus non-index hospitals and to identify factors associated with non-index hospital readmission...
July 23, 2018: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
Kevin C Heslin, Pamela L Owens, Lisa A Simpson, James P Guevara, Marie C McCormick
OBJECTIVE: The aim of this study is to describe trends in unplanned 30-day all-condition hospital readmissions for children aged 1 to 17 years between 2009 and 2014. STUDY DESIGN: Analysis was conducted with the 2009-2014 Nationwide Readmissions Database (NRD) from the Agency for Healthcare Research and Quality's Healthcare Cost and Utilization Project. Annual hospital readmission rates, resource use, and the most common reasons for readmission were calculated for the 2009-2014 period...
July 19, 2018: Academic Pediatrics
Raymond Cespuglio
Serotonin (5-HT) is involved in sleep in two different ways. First, when released during waking by the axonal nerve endings, it influences the synthesis of hypnogenic substances in specific brain targets. Such a synthesis might be in keeping with the waking qualitative aspects. As an example, the hypnogenic CLIP peptide (ACTH18-39 ) is synthesized when stressful events occur during wakefulness. Second, when released during sleep within the nucleus raphe dorsalis (nRD) by dendrites of 5-HT neurons, it contributes to 5-HT perikarya silencing through an auto-inhibitory process...
June 6, 2018: Sleep Medicine
Lindsay A Sobotka, Rohan M Modi, Akshay Vijayaraman, A James Hanje, Anthony J Michaels, Lanla F Conteh, Alice Hinton, Ashraf El-Hinnawi, Khalid Mumtaz
AIM: To determine the readmission rate, its reasons, predictors, and cost of 30-d readmission in patients with cirrhosis and ascites. METHODS: A retrospective analysis of the nationwide readmission database (NRD) was performed during the calendar year 2013. All adults cirrhotics with a diagnosis of ascites, spontaneous bacterial peritonitis, or hepatic encephalopathy were identified by ICD-9 codes. Multivariate analysis was performed to assess predictors of 30-d readmission and cost of readmission...
June 27, 2018: World Journal of Hepatology
Fabio Bagante, Eliza W Beal, Katiuscha Merath, Anghela Paredes, Jeffery Chakedis, Griffin Olsen, Ozgür Akgül, Jay Idrees, Quinu Chen, Timothy M Pawlik
BACKGROUND AND OBJECTIVES: Reducing readmissions is an important quality improvement metric. We sought to investigate patterns of 90-day readmission after hepato-pancreatic (HP) procedures. METHODS: The Nationwide Readmissions Database (NRD) was used to identify patients undergoing HP procedures between 2010 and 2014. Patients were stratified according to benign versus malignant HP diagnoses and as index (same hospital as operation) versus non-index (different hospital) readmissions...
June 2018: Journal of Surgical Oncology
Kavelin Rumalla, Kyle A Smith, Kenneth A Follett, Jules M Nazzaro, Paul M Arnold
OBJECTIVE: Deep brain stimulation (DBS) surgery has proven benefit for several movement disorders and medically-refractory psychiatric conditions and is considered a fairly safe procedure. We sought to determine the national rates, causes, predictors, and outcomes associated with 30-day and 90-day readmission. PATIENTS AND METHODS: The Nationwide Readmissions Database was queried (January-September 2013) using ICD-9-CM codes, identifying patients who underwent DBS for movement disorder (Parkinson's disease [PD], essential tremor [ET], or dystonia)...
August 2018: Clinical Neurology and Neurosurgery
Shilpkumar Arora, Sopan Lahewala, Byomesh Tripathi, Varshil Mehta, Varun Kumar, Divya Chandramohan, Alejandro Lemor, Mihir Dave, Nileshkumar Patel, Nilay V Patel, Ghanshyam Palamaner Subash Shantha, Juan Viles-Gonzalez, Abhishek Deshmukh
BACKGROUND: Reducing readmission after catheter ablation (CA) in atrial fibrillation (AF) is important. METHODS AND RESULTS: We utilized National Readmission Data (NRD) 2010-2014. AF was identified by International Classification of Diseases, Ninth Edition, Clinical Modification (ICD-9-CM) diagnostic code 427.31 in the primary field, while first CA of AF was identified via ICD-9 -procedure code 37.34. Any admission within 30 or 90 days of index admission was considered a readmission...
June 15, 2018: Journal of the American Heart Association
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