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Ponsit Sathapondecha, Wilaiwan Chotigeat
In shrimp aquaculture, eyestalk ablation is the only technique that is widely used to accelerate ovarian development. Alternative methods for producing improved ovarian development in broodstock are currently being investigated. Several factors involved in the regulation of ovarian development in shrimp have been investigated. Among these factors, growth factors in the transforming growth factor beta (TGF-β) superfamily have been implicated as playing potential roles in the regulation of gonad development...
October 10, 2018: General and Comparative Endocrinology
Shupeng Chen, Hongxia Liu, Shulong Wang, Wei Li, Xing Wang, Lu Zhao
In this paper, a silicon-based T-shape gate dual-source tunnel field-effect transistor (TGTFET) is proposed and investigated by TCAD simulation. As a contrastive study, the structure, characteristic, and analog/RF performance of TGTFET, LTFET, and UTFET are discussed. The gate overlap introduced by T-shape gate can enhance the efficiency of tunneling junction. The dual-source regions in TGTFET can increase the on-state current (ION ) by offering a doubled tunneling junction area. In order to further improve the device performance, the n+ pocket is introduced in TGTFET to further increase the band-to-band tunneling rate...
October 12, 2018: Nanoscale Research Letters
Makoto Komatsuzaki, Shinsuke Hamaguchi
Although there is no remarkable change of anesthetics or anesthesia methods in recent years, several new technologies are used for safety management of cardiac, lung or thoracic surgery. Stroke volume variation (SVV) monitoring indicates SVV, a parameter to optimize fluid infusion and is used to avoid edema or congestive heart damage due to over hydration. SmartPilot View, a pharmacokinetic simulator during anesthesia, represents the measured effective site concentration of anesthetics and contributes the optimization of induction and maintenance of anesthesia...
September 2018: Kyobu Geka. the Japanese Journal of Thoracic Surgery
Ryota Watanabe, Beatriz P Monteiro, Marina C Evangelista, Amélie Castonguay, Daniel Edge, Paulo V Steagall
BACKGROUND: Buprenorphine is a potent lipophilic opioid analgesic that is largely used in the multimodal treatment of acute pain. Simbadol (buprenorphine hydrochloride) is the first and only FDA-approved high-concentration formulation of buprenorphine for use in cats. The aim of this study was to evaluate the analgesic efficacy of carprofen in combination with one of two commercial formulations of buprenorphine (Simbadol and Vetergesic, 1.8 mg/mL and 0.3 mg/mL, respectively) in dogs undergoing ovariohysterectomy...
October 5, 2018: BMC Veterinary Research
Chunjuan Song, Thomas J Conlon, Wen-Tao Deng, Kirsten E Coleman, Ping Zhu, Cayrn Plummer, Savitri Mandapati, Mailin Van Hoosear, Kari B Green, Peter Sonnentag, Alok K Sharma, Adrian Timmers, Paulette Robinson, David R Knop, William W Hauswirth, Jeffrey David Chulay, Mark S Shearman, Guo-Jie Ye
AGTC is developing a recombinant adeno-associated virus (rAAV) vector AGTC-501, also designated AAV2tYF-GRK1-RPGRco, to treat retinitis pigmentosa (RP) in patients with mutations in the retinitis pigmentosa GTPase regulator (RPGR) gene. The vector contains a codon-optimized human RPGR cDNA (RPGRco) driven by a photoreceptor-specific promoter (G protein-coupled receptor kinase 1, GRK1) and is packaged in an AAV2 capsid with three surface tyrosine residues changed to phenylalanine (AAV2tYF). We conducted a safety and potency study of this vector administered by subretinal injection in the naturally occurring RPGR-deficient Rd9 mouse model...
October 3, 2018: Human Gene Therapy. Clinical Development
Qiong Yao, Shu Xu, Yizhi Dong, Yinli Que, Linfa Quan, Bingxu Chen
Conopomorpha sinensis Bradley is the dominant borer pest of Litchi chinesis and Euphoria longan . Current management of C. sinensis relies upon insecticide application to adult moths. In addition to the direct mortality induced by insecticides, a sublethal dose of insecticides also affects growth, survival, and reproduction in the exposed insects. Vitellogenin (Vg) and vitellogenin receptor (VgR) are normally identified as essential reproduction-related proteins in insects. In this study, we characterized these two genes from C...
2018: Frontiers in Physiology
Tathyana Rachel Palo Mello, Aline Carolina Aleixo, Daniel Guariz Pinheiro, Francis Morais Franco Nunes, Alexandre Santos Cristino, Márcia Maria Gentile Bitondi, Angel Roberto Barchuk, Zilá Luz Paulino Simões
Ftz-f1 is an orphan member of the nuclear hormone receptor superfamily. A 20-hydroxyecdysone pulse allows ftz-f1 gene expression, which then regulates the activity of downstream genes involved in major developmental progression events. In honeybees, the expression of genes like vitellogenin (vg), prophenoloxidase, and juvenile hormone-esterase, during late pharate-adult development is known to be hormonally controlled in both queens and workers by increasing juvenile hormone (JH) titers in the presence of declining levels of ecdysteroids...
September 30, 2018: Insect Molecular Biology
Lucas Alverne F Albuquerque, Fátima C Pessoa, Gabryella S Diógenes, Felipe S Borges, Stélio C Araújo Filho
Cavernous angiomas constitute 5%-10% of cerebrovascular malformations and may cause seizure and neurological deficits from bleeding. 4 The authors present a case of a 44-year-old man with a 3.5-year history of epilepsy without complete seizure control despite anticonvulsants. Brain MRI showed a 2.8 cm cavernous angioma at the left pars opercularis, also known as the Broca's area. 3 The patient underwent an awake craniotomy for intraoperative cortical-subcortical language and sensory-motor mapping for a complete resection of the cavernous angioma and the hemosiderin rim...
October 2018: Neurosurgical Focus
Efthimios Zervas, Eleni Litsiou, Konstantinos Konstantopoulos, Stavros Poulopoulos, Paraskevi Katsaounou
Electronic cigarettes are used to evaporate a mixture of solvents, nicotine and flavors. Liquid particles can be generated under these conditions due to evaporation/condensation. The objective of this work is to measure the physical characteristics of the aerosol emission of an e-cigarette using different refill liquids. The aerosol particle number and size are determined with a Scanning Mobility Particle Sizer. Seven liquids are used: propylene glycol (PG), glycerol (VG), a mixture 1:1 of PG/VG, the mixture with 2% or 5% of a commercial flavor, the mixture with 1...
September 26, 2018: Inhalation Toxicology
Yoshihide Sehara, Toshiki Inaba, Takao Urabe, Fumio Kurosaki, Masashi Urabe, Naoki Kaneko, Kuniko Shimazaki, Kensuke Kawai, Hiroaki Mizukami
Survivin, a member of the inhibitors of apoptosis protein gene family, inhibits the activity of caspase, leading to a halt of the apoptotic process. Our study focused on the neuroprotective effect of survivin after transient middle cerebral artery occlusion (MCAO) with intraparenchymal administration of an adeno-associated virus (AAV) vector. His-tagged survivin was cloned and packaged into the AAV-rh10 vector. Four-week-old Sprague-Dawley rats were injected with 4×109 vg of AAV-GFP or AAV-His-survivin into the right striatum and were treated three weeks later with transient MCAO for 90 minutes...
September 25, 2018: European Journal of Neuroscience
Yan Guo, Ary A Hoffmann, Xiao-Qin Xu, Pei-Wen Mo, Hai-Jian Huang, Jun-Tao Gong, Jia-Fei Ju, Xiao-Yue Hong
Wolbachia in host germ lines are essential for their vertical transmission to the next generation. It is unclear how the regulation of host oocyte development influences Wolbachia location and the mechanistic basis of transmission. Here, we investigated whether vitellogenin influences Wolbachia transmission in Laodelphax striatellus . Wolbachia increased in density and spread from the anterior tropharium to developing oocytes as ovaries developed. Microscopic observations indicated that Wolbachia invaded ovarioles from the tropharium of its anterior side rather than the pedicel side...
2018: Frontiers in Microbiology
Eniko Szakmar, Colin J Morley, Gusztav Belteki
OBJECTIVES: To report how peak inflating pressure (PIP), tidal volume (VT) and low-tidal volume alarms are affected by maximum allowed inflating pressure (Pmax ) during volume guarantee (VG) ventilation. STUDY DESIGN: Ventilation data were analysed with 1 Hz sampling rate from 25 neonates receiving synchronised intermittent positive pressure ventilation with VG for >12 h. RESULTS: The difference between Pmax and PIP (Pdiff ) ranged between 5 and 20 mbar (median = 11 mbar) despite a protocol to keep Pmax 5 mbar above the "working PIP"...
September 19, 2018: Journal of Perinatology: Official Journal of the California Perinatal Association
Gusztav Belteki, Colin J Morley
OBJECTIVE: High-frequency oscillatory ventilation (HFOV) is widely used in neonatology. The Dräger Babylog VN500 ventilator offers volume-guaranteed HFOV (HFOV-VG) mode when the high-frequency tidal volume (VThf) to be delivered can be set. We investigated how HFOV-VG maintains VThf in the short and longer term and how it affects other ventilator parameters and blood gases. METHODS: We downloaded ~3.2 million seconds (36.7 days) of ventilator data from 17 infants ventilated using HFOV-VG during clinical care with 1 Hz sampling rate...
September 14, 2018: Archives of Disease in Childhood. Fetal and Neonatal Edition
Na Xin, Xingxing Li, Chuancheng Jia, Yao Gong, Mingliang Li, Shuopei Wang, Guangyu Zhang, Jinlong Yang, Xuefeng Guo
Achieving gate control with atomic precision, which is crucial to the transistor performance on the smallest scale, remains a challenge. Herein we report a new class of aromatic-ring molecular nanotransistors based on graphene-molecule-graphene single-molecule junctions by using an ionic-liquid gate. Experimental phenomena and theoretical calculations confirm that this ionic-liquid gate can effectively modulate the alignment between molecular frontier orbitals and the Fermi energy level of graphene electrodes, thus tuning the charge-transport properties of the junctions...
October 22, 2018: Angewandte Chemie
Wen-Qiang Liu, Yan Xu, Ai-Min Han, Ling-Jian Meng, Jun Wang
OBJECTIVE: To compare the efficacy between synchronized intermittent mandatory ventilation (SIMV) and pressure support ventilation with volume guarantee (PSV+VG) in the weaning phase of preterm infants with respiratory distress syndrome (RDS). METHODS: Forty preterm infants with RDS who were admitted to the neonatal intensive care unit between March 2016 and May 2017 were enrolled as subjects. All infants were born at less than 32 weeks' gestation and received mechanical ventilation...
September 2018: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
Hoda Hatoum, Lakshmi P Dasi
Blood damage and platelet activation are inherent problems with present day bi-leaflet mechanical heart valve designs. Passive flow control through different arrangements of vortex generators (VG) as means of improving pressure gradients and reducing turbulence are investigated. Rectangular VG arrays were mounted on the downstream surfaces of a 23 mm 3D printed mechanical valve. The effect of VGs on the resulting flow structures were assessed under pulsatile physiological flow conditions where high resolution particle image velocimetry measurement was performed...
September 12, 2018: Annals of Biomedical Engineering
Catherine Cukras, Henry E Wiley, Brett G Jeffrey, H Nida Sen, Amy Turriff, Yong Zeng, Camasamudram Vijayasarathy, Dario Marangoni, Lucia Ziccardi, Sten Kjellstrom, Tae Kwon Park, Suja Hiriyanna, J Fraser Wright, Peter Colosi, Zhijian Wu, Ronald A Bush, Lisa L Wei, Paul A Sieving
This study evaluated the safety and tolerability of ocular RS1 adeno-associated virus (AAV8-RS1) gene augmentation therapy to the retina of participants with X-linked retinoschisis (XLRS). XLRS is a monogenic trait affecting only males, caused by mutations in the RS1 gene. Retinoschisin protein is secreted principally in the outer retina, and its absence results in retinal cavities, synaptic dysfunction, reduced visual acuity, and susceptibility to retinal detachment. This phase I/IIa single-center, prospective, open-label, three-dose-escalation clinical trial administered vector to nine participants with pathogenic RS1 mutations...
September 5, 2018: Molecular Therapy: the Journal of the American Society of Gene Therapy
Christina Haddad, Rola Salman, Ahmad El-Hellani, Soha Talih, Alan Shihadeh, Najat Aoun Saliba
Electronic cigarettes (ECIGs) are battery-powered devices that heat and vaporize solutions containing propylene glycol (PG) and/or vegetable glycerin (VG), nicotine and possible trace flavorants to produce an inhalable aerosol. The heating process can lead to the formation of reactive oxygen species (ROS), which are linked to various oxidative damage-initiated diseases. Several studies in the literature have addressed ROS emissions in ECIG aerosols, but the effects of power, ECIG device design and liquid composition on ROS are relatively unknown...
September 6, 2018: Journal of Analytical Toxicology
Xi Xie, Mingxin Liu, Qinghua Jiang, Hongkun Zheng, Liang Zheng, Dongfa Zhu
Similar to the role of juvenile hormone (JH) in insects, methyl farnesoate (MF), the unepoxidized form of JH III, regulates many developmental processes in crustaceans, such as molting and reproduction. We have previously showed that the JH receptor, Methoprene-tolerant (Met), which is also a candidate receptor for MF, might be involved in the MF-mediated vitellogenesis in the swimming crab Portunus trituberculatus. In this study, the role of Kruppel homolog 1 (Kr-h1), a transcription factor downstream Met in JH signaling, was further investigated...
September 4, 2018: Gene
Katsuhiko Mizuno, Kenji Takeuchi, Ken Umehara, Miki Nakajima
The dipeptidyl peptidase-4 (DPP-4) inhibitor vildagliptin (VG) is used to treat type 2 diabetes. In rare cases, VG-induced liver injury has been reported. One case report suggested that immune responses were involved in the hepatotoxicity. However, the underlying mechanisms of VG-induced hepatotoxicity are uncertain. In the present study, we investigated whether VG has the potential to covalently bind to macromolecules in cells, a process that could initiate immune-mediated hepatotoxicity. For comparison, M20...
August 31, 2018: Biochemical Pharmacology
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