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https://www.readbyqxmd.com/read/29468975/the-protective-effects-of-green-tea-catechins-in-the-management-of-neurodegenerative-diseases-a-review
#1
Tahereh Farkhondeh, Hanieh Shaterzadeh Yazdi, Saeed Samarghandian
The therapeutic strategies to manage neurodegenerative diseases remain limited and it is necessary to discover new agents for their prevention and control. Oxidative stress and inflammation play a main role in the pathogenesis of neurodegenerative diseases. Catechins, the major flavonoids in green tea, are powerful antioxidants and radical scavengers that possess the potential roles in the management of neurodegenerative diseases. Catechins modulate the cellular and molecular mechanisms through the inflammation-related NF-кB and the nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathways...
February 18, 2018: Current Drug Discovery Technologies
https://www.readbyqxmd.com/read/29467931/toll-like-receptor-2-induces-adenosine-receptor-a2a-and-promotes-human-squamous-carcinoma-cell-growth-via-extracellular-signal-regulated-kinases-%C3%A2
#2
Chithra Devi Palani, Lalitha Ramanathapuram, Aroonwan Lam-Ubol, Zoya B Kurago
Patient treatment for oral squamous cell carcinoma (OSCC) not associated with Human papillomavirus remains problematic. OSCC microenvironment is typically inflamed and colonized by microorganisms, providing ligands for toll-like receptors (TLR). In immune cells TLR2 and TLR4 activate NF-kB and extracellular signal regulated kinase (ERK)1/2 pathways, leading to upregulation of inhibitory adenosine receptors A2a and A2b, and reduction in stimulatory A1 and A3. How TLR and adenosine receptors function in SCC cells is not understood...
January 23, 2018: Oncotarget
https://www.readbyqxmd.com/read/29462603/lox-1-receptor-a-potential-link-in-atherosclerosis-and-cancer
#3
REVIEW
Silvana Balzan, Valter Lubrano
Altered production of reactive oxygen species (ROS), causing lipid peroxidation and DNA damage, contributes to the progression of atherosclerosis and cancer. Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is a lectin-like receptor for oxidized low-density lipoproteins (ox-LDL) primarily expressed in endothelial cells and vasculature-rich organs. LOX-1 receptors is a marker for atherosclerosis, and once activated by ox-LDL or other ligands, stimulates the expression of adhesion molecules, pro-inflammatory signaling pathways and proangiogenic proteins, including NF-kB and VEGF, in vascular endothelial cells and macrophages...
February 17, 2018: Life Sciences
https://www.readbyqxmd.com/read/29458159/strawberry-extracts-efficiently-counteract-inflammatory-stress-induced-by-the-endotoxin-lipopolysaccharide-in-human-dermal-fibroblast
#4
Massimiliano Gasparrini, Francesca Giampieri, Tamara Y Forbes-Hernandez, Sadia Afrin, Danila Cianciosi, Patricia Reboredo-Rodriguez, Alfonso Varela-Lopez, JiaoJiao Zhang, Josè L Quiles, Bruno Mezzetti, Stefano Bompadre, Maurizio Battino
A protracted pro-inflammatory state is the common denominator in the development, progression and complication of the common chronic diseases. Dietary antioxidants represent an efficient tool to counteract this inflammatory state. The aim of the present work was to evaluate the effects of strawberry extracts on inflammation evoked by E. Coli lipopolysaccharide in Human Dermal Fibroblast, by measuring reactive oxygen species production, apoptosis rate, antioxidant enzymes activity, mitochondria functionality and also investigating the molecular pathway involved in inflammatory and antioxidant response...
February 16, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29458123/osteocyte-regulation-of-bone-and-blood
#5
REVIEW
Paola Divieti Pajevic, Daniela S Krause
This past decade has witnessed a renewed interest in the function and biology of matrix-embedded osteocytes and these cells have emerged as master regulators of bone homeostasis. They secrete two very powerful proteins, sclerostin, a Wnt-inhibitor, that suppresses bone formation, and receptor-activator of NF-kB ligand (RANKL), a cytokine required for osteoclastogenesis. Neutralizing antibodies against these proteins are currently used for the treatment of osteoporosis. Recent studies however, ascribed yet another function to osteocytes: the control of hematopoiesis and the HSPC niche, directly and through secreted factors...
February 16, 2018: Bone
https://www.readbyqxmd.com/read/29456507/the-effects-of-vitamin-d-supplementation-on-signaling-pathway-of-inflammation-and-oxidative-stress-in-diabetic-hemodialysis-a-randomized-double-blind-placebo-controlled-trial
#6
Hamed Haddad Kashani, Elahe Seyed Hosseini, Hossein Nikzad, Alireza Soleimani, Maryam Soleimani, Mohammad Reza Tamadon, Fariba Keneshlou, Zatollah Asemi
Objective: This study was carried out to determine the effects of vitamin D supplementation on signaling pathway of inflammation and oxidative stress in diabetic hemodialysis (HD) patients. Methods: This randomized double-blind placebo-controlled clinical trial was conducted among 60 diabetic HD patients. Subjects were randomly allocated into two groups to intake either vitamin D supplements at a dosage of 50,000 IU ( n = 30) or placebo ( n = 30) every 2 weeks for 12 weeks. Gene expression of inflammatory cytokines and biomarkers of oxidative stress were assessed in peripheral blood mononuclear cells (PBMCs) of diabetic HD patients with RT-PCR method...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29453519/tricurin-a-synergistic-formulation-of-curcumin-resveratrol-and-epicatechin-gallate-repolarizes-tumor-associated-macrophages-and-triggers-an-immune-response-to-cause-suppression-of-hpv-tumors
#7
Sumit Mukherjee, Rahman Hussaini, Richard White, Doaa Atwi, Angela Fried, Samay Sampat, Longzhu Piao, Quintin Pan, Probal Banerjee
Our earlier studies reported a unique potentiated combination (TriCurin) of curcumin (C) with two other polyphenols. The TriCurin-associated C displays an IC50 in the low micromolar range for cultured HPV+ TC-1 cells. In contrast, because of rapid degradation in vivo, the TriCurin-associated C reaches only low nano-molar concentrations in the plasma, which are sub-lethal to tumor cells. Yet, injected TriCurin causes a dramatic suppression of tumors in TC-1 cell-implanted mice (TC-1 mice) and xenografts of Head and Neck Squamous Cell Carcinoma (HNSCC) cells in nude/nude mice...
February 16, 2018: Cancer Immunology, Immunotherapy: CII
https://www.readbyqxmd.com/read/29452637/ubiquitin-mediated-regulation-of-ripk1-kinase-activity-independent-of-ikk-and-mk2
#8
Alessandro Annibaldi, Sidonie Wicky John, Tom Vanden Berghe, Kirby N Swatek, Jianbin Ruan, Gianmaria Liccardi, Katiuscia Bianchi, Paul R Elliott, Sze Men Choi, Samya Van Coillie, John Bertin, Hao Wu, David Komander, Peter Vandenabeele, John Silke, Pascal Meier
Tumor necrosis factor (TNF) can drive inflammation, cell survival, and death. While ubiquitylation-, phosphorylation-, and nuclear factor κB (NF-κB)-dependent checkpoints suppress the cytotoxic potential of TNF, it remains unclear whether ubiquitylation can directly repress TNF-induced death. Here, we show that ubiquitylation regulates RIPK1's cytotoxic potential not only via activation of downstream kinases and NF-kB transcriptional responses, but also by directly repressing RIPK1 kinase activity via ubiquitin-dependent inactivation...
February 15, 2018: Molecular Cell
https://www.readbyqxmd.com/read/29447858/intrathecal-injection-of-scaav9-higf1-prolongs-the-survival-of-als-model-mice-by-inhibiting-the-nf-kb-pathway
#9
HaoJie Hu, HuiQian Lin, WeiSong Duan, Can Cui, ZhongYao Li, YaKun Liu, Wan Wang, Di Wen, Ying Wang, ChunYan Li
Amyotrophic lateral sclerosis (ALS) is a chronic, fatal neurodegenerative disorder characterized by the progressive loss of upper and lower motor neurons. Currently, there is no effective drug for ALS. Recent studies in ALS model mice have shown that insulin-like growth factor-1 (IGF1) may be a promising therapeutic drug. We demonstrate that self-complementary adeno-associated virus serum type 9 encoding the human IGF1 (scAAV9-hIGF1) could significantly postpone the onset and slow down the progression of the disease owning to inhibiting the NF-κB signalling pathway...
February 12, 2018: Neuroscience
https://www.readbyqxmd.com/read/29446054/upregulation-of-pro-inflammatory-cytokine-expression-following-chronic-paracetamol-treatment-in-astrocyte
#10
Nutnicha Tantarungsee, Waranurin Yisarakun, Thananya Thongtan, Laddawan Lalert, Sirinapa Srikam, Preecha Reuangwechvorachai, Praewphan Ingruanglert, Supang Maneesri-le Grand
The present study aimed to investigate the effect of APAP treatment on the expression of pro-inflammatory cytokines in the astrocytes. The mouse astrocyte cells (C8-D1A) were treated with APAP at the concentration of 100 μM for 24 h, 16 and 28 days. The expressions of pro-inflammatory cytokines and NF-kB were determined using western blot analysis. Furthermore, the expression and localization of phosphorylation of NF-kB were detected by immunohistochemical and immunofluorescent analysis. The ultrastructure of C8-D1A cells was as well monitored...
February 14, 2018: Neurotoxicity Research
https://www.readbyqxmd.com/read/29442198/hgf-reduces-disease-severity-and-inflammation-by-attenuating-the-nf-%C3%AE%C2%BAb-signaling-in-a-rat-model-of-pulmonary-artery-hypertension
#11
Ying Pang, Ming-Ting Liang, Ying Gong, Yong Yang, Pei-Li Bu, Mei Zhang, Heng-Chen Yao
The purpose of the present study was to investigate the anti-inflammatory effect of hepatocyte growth factor (HGF) on pulmonary artery hypertension (PAH) in a rat model and underlying mechanisms. Wistar rats were treated with monocrotaline intravenously to induce PAH and then treated with vehicle or HGF for 2 weeks, respectively. The mean pulmonary artery pressure (mPAP), the index of right heart ventricular hypertrophy (RHVI), pathological changes, and inflammation in the lungs of individual rats were measured...
February 13, 2018: Inflammation
https://www.readbyqxmd.com/read/29440395/fatty-acid-binding-protein-5-controls-microsomal-prostaglandin-e-synthase-1-mpges-1-induction-during-inflammation
#12
Diane Bogdan, Jerome Falcone, Martha P Kanjiya, Sang Hoon Park, Gregory Carbonetti, Keith Studholme, Maria Gomez, Yong Lu, Matthew W Elmes, Norbert Smietalo, Su Yan, Iwao Ojima, Michelino Puopolo, Martin Kaczocha
Fatty acid binding proteins (FABPs) are intracellular lipid carriers that regulate inflammation, and pharmacological inhibition of FABP5 reduces inflammation and pain. The mechanism(s) underlying the anti-inflammatory effects associated with FABP5 inhibition are poorly understood. Herein, we identify a novel mechanism through which FABP5 modulates inflammation. In mice, intraplantar injection of carrageenan induces acute inflammation that is accompanied by edema, enhanced pain sensitivity, and elevations in pro-inflammatory cytokines and prostaglandin E2 (PGE2)...
February 13, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29438846/six-genes-of-ompa-family-shuffling-for-development-of-polyvalent-vaccines-against-vibrio-alginolyticus-and-edwardsiella-tarda
#13
Zhi-Xue Cheng, Xiao Chu, Sheng-Nan Wang, Xuan-Xian Peng, Hui Li
Polyvalent vaccines against more than one species of pathogens are especially important due to the complex ecosystem in aquaculture. We have previously shown that the development of polyvalent vaccines by shuffling six ompA genes from different bacteria with V. parahaemolyticus VP0764 primers. Here, we used the same 6 genes, V. alginolyticus VA0764 and VA1186, V. parahaemolyticus VP0764 and VP1186, E. tarda ompA and E. coli ompA, but with E. tarda ompA primers to develop new polyvalent vaccines. By this approach, we identified 7 potential polyvalent vaccines that were effective against both V...
February 10, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29437267/pharmacoproteomics-profile-in-response-to-acamprosate-treatment-of-an-alcoholism-animal-model
#14
Caroline E Germany, Ashlie N Reker, David J Hinton, Alfredo Oliveros, Xinggui Shen, Lindsey G Andres-Beck, Katheryn M Wininger, Marjan Trutchul, Urska Cvek, Doo-Sup Choi, Hyung W Nam
Acamprosate is an FDA-approved medication for the treatment of alcoholism that is unfortunately only effective in certain patients. Although acamprosate known to stabilize the hyper-glutamatergic state in alcoholism, pharmacological mechanisms of action in brain tissue remains unknown. To investigate the mechanism of acamprosate efficacy, we employed a pharmacoproteomics approach using an animal model of alcoholism, type 1 equilibrative nucleoside transporter (ENT1) null mice. Our results demonstrated that acamprosate treatment significantly decreased both ethanol drinking and preference in ENT1 null mice compared to that of wild-type mice...
February 13, 2018: Proteomics
https://www.readbyqxmd.com/read/29434591/angiotensin-1-7-promotes-resolution-of-eosinophilic-inflammation-in-an-experimental-model-of-asthma
#15
Giselle S Magalhaes, Lívia C Barroso, Alesandra C Reis, Maria G Rodrigues-Machado, Juliana F Gregório, Daisy Motta-Santos, Aline C Oliveira, Denise A Perez, Lucíola S Barcelos, Mauro M Teixeira, Robson A S Santos, Vanessa Pinho, Maria Jose Campagnole-Santos
Defective apoptosis of eosinophils, the main leukocyte in the pathogenesis of asthma, and delay in its removal lead to lung damage and loss of pulmonary function due to failure in the resolution of inflammation. Here, we investigated the ability of angiotensin-(1-7) [Ang-(1-7)], a pivotal peptide of the renin-angiotensin system, to promote resolution of an allergic lung inflammatory response. Balb/c mice were sensitized and challenged with ovalbumin and treated with Ang-(1-7) at the peak of the inflammatory process...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29432887/role-of-brain-neuroinflammatory-factors-on-hypertension-in-the-spontaneously-hypertensive-rat
#16
Ennio Avolio, Teresa Pasqua, Anna Di Vito, Gilda Fazzari, Gabriella Cardillo, Raffaella Alò, Maria Carmela Cerra, Tullio Barni, Tommaso Angelone, Marcello Canonaco
It is already widely known that the different brain areas involved in blood pressure control, are highly vulnerable to the deleterious effects of this condition. Of particular concern are hypertensive and neuroinflammatory-dependent injuries that by modifying blood flow account for artery structural and functional alterations. It was thus our intention to establish if expression changes of some key brain neuroinflammatory factors like caspase-1,3, NF-kB, IL-1β and NLRP3, which are known to control blood pressure, are actively involved with inflammation regulatoryevents in a highly valuable spontaneously hypertensive rat (SHR) model...
February 9, 2018: Neuroscience
https://www.readbyqxmd.com/read/29432836/quercetin-attenuates-the-hyperoxic-lung-injury-in-neonatal-mice-implications-for-bronchopulmonary-dysplasia-bpd
#17
Paramahamsa Maturu, Yanhong Wei-Liang, Vasilis P Androutsopoulos, Weiwu Jiang, Lihua Wang, Aristides M Tsatsakis, Xanthi I Couroucli
Quercetin (QU) is one of the most common flavonoids that are present in a wide variety of fruits, vegetables, and beverages. This compound possesses potent anti-inflammatory and anti-oxidant properties. Supplemental oxygen is routinely administered to premature infants with pulmonary insufficiency. However, hyperoxia is one of the major risk factors for the development of bronchopulmonary dysplasia (BPD), which is also termed chronic lung disease in premature infants. Currently, no preventive approaches have been reported against BPD...
February 9, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29431638/s-nitrosylation-of-ciap1-switches-cancer-cell-fate-from-tnf%C3%AE-tnfr1-mediated-cell-survival-to-cell-death
#18
Sabrina Romagny, Sarra Bouaouiche, Géraldine Lucchi, Patrick Ducoroy, Jean Borges Bertoldo, Hernan Terenzi, Ali Bettaieb, Stéphanie Plenchette
Tumor necrosis factor alpha (TNFα) is a prominent proinflammatory cytokine and a critical mediator for the development of many types of cancer such as breast, colon, prostate, cervical, skin, liver, and chronic lymphocytic leukemia. Binding of TNFα to TNFR1 can lead to divergent signaling pathways promoting predominantly NF-kB activation but also cell death. We report here that the nitric oxide donor glyceryl trinitrate (GTN) converts TNFα, generated from immune cells or cancer cells stimulated by chemotherapy, into a pro-death mediator in colon and mammary cancer cells...
February 5, 2018: Cancer Research
https://www.readbyqxmd.com/read/29429000/prunus-cerasoides-fruit-extract-ameliorates-inflammatory-stress-by-modulation-of-inos-pathway-and-th1-th2-immune-homeostasis-in-activated-murine-macrophages-and-lymphocytes
#19
Anamika Sharma, Robin Joshi, Shiv Kumar, Rohit Sharma, Rajneesh, Yogendra Padwad, Mahesh Gupta
The present investigation assessed the potential of Prunus cerasoides fruit extract (PCFE) in alleviation of inflammatory stress in response to lipopolysaccharide (LPS) and interferon-γ (IFN-γ)-stimulated murine peritoneal macrophages as well as in concanavalin A (Con A)-activated splenic lymphocytes. We observed a strong inhibition in production of nitric oxide (NO), reactive oxygen species (ROS), inflammatory cytokines (TNF-α/IL-6/IL-1β), inducible nitric oxide synthase (iNOS), and NF-kB in macrophages treated with PCFE...
February 10, 2018: Inflammopharmacology
https://www.readbyqxmd.com/read/29428944/clusterin-reduces-cold-ischemia-reperfusion-injury-in-heart-transplantation-through-regulation-of-nf-kb-signaling-and-bax-bcl-xl-expression
#20
Guodong Liu, Hongmei Zhang, Fengyun Hao, Jing Hao, Lixiao Pan, Qing Zhao, Jinshan Wo
BACKGROUND/AIMS: Ischemia-reperfusion (I/R) injury is an unavoidable event occurring during heart transplantation and is a key factor in graft failure and the long-term survival rate of recipients. Therefore, there is an urgent need for the development of new therapies to prevent I/R injury. Clusterin is a hetero-dimeric glycoprotein with an antiapoptotic function. In this study, we investigated whether clusterin was cardioprotective in heart transplantation against I/R injury using an in vivo rat model and an in vitro cell culture system, and examined the underlying mechanisms of I/R injury...
February 5, 2018: Cellular Physiology and Biochemistry
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