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Thilo Noack, Philipp Kiefer, Linda Mallon, Philipp Lurz, Carmine Bevilacqua, Joergen Banusch, Fabian Emrich, David M Holzhey, Mani Vannan, Holger Thiele, Friedrich-Wilhelm Mohr, Michael Andrew Borger, Joerg Ender, Joerg Seeburger
BACKGROUND: The aim of this study was to quantify the acute dynamic changes of mitral valve (MV) geometry throughout the cardiac cycle-during percutaneous MV repair with the MitraClip system by 3-dimensional transesophageal echocardiography (3D TEE). METHODS: The MV was imaged throughout the cardiac cycle (CC) before and after the MitraClip procedure using 3D TEE in 28 patients (mean age, 77 ± 8 years) with functional mitral regurgitation (FMR). Dynamic changes in the MV annulus geometry and anatomical MV orifice area (AMVOA) were quantified using a novel semi-automated software...
October 5, 2018: Journal of Echocardiography
Pedro Morais, Sandro Queiros, Pieter De Meester, Werner Budts, Joao L Vilaca, Joao Manuel R S Tavares, Jan D'hooge
Left atrial appendage (LAA) has been generally described as "our most lethal attachment", being considered the major source of thromboembolism in patients with non-valvular atrial fibrillation. Currently, LAA occlusion can be offered as a treatment for these patients, obstructing the LAA through a percutaneously delivered device. Nevertheless, correct device sizing is not straightforward, requiring the manual analysis of peri-procedural images. This approach is sub-optimal, time demanding and highly variable between experts, which can result in lengthy procedures and excess manipulations...
September 28, 2018: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
Noman Ali, Smriti Saraf, Dominik Schlosshan, Michael Cunnington, Christopher J Malkin, Daniel J Blackman
Trans-catheter aortic valve implantation (TAVI) has become an established treatment for inoperable and high-surgical risk patients with severe, symptomatic aortic stenosis (AS). Post-procedural acute kidney injury (AKI) is a frequent complication following TAVI and is associated with increased mortality. Patients with pre-existing chronic renal impairment are at particularly high risk. The etiology of post-TAVI AKI is multi-factorial, but the principal procedural issues are contrast-induced nephropathy, and renal hypoperfusion secondary to intra-procedural hypotension...
October 2018: Journal of Cardiology Cases
Fabien Praz, Omar K Khalique, Leon G Dos Reis Macedo, Todd C Pulerwitz, Jennifer Jantz, Isaac Y Wu, Alex Kantor, Amisha Patel, Torsten Vahl, Vinayak Bapat, Isaac George, Tamim Nazif, Susheel K Kodali, Martin B Leon, Rebecca T Hahn
BACKGROUND: Tricuspid valve imaging is frequently challenging and requires the use of multiple modalities. Knowledge of limitations and methodologic discrepancies among different imaging techniques is crucial for planning transcatheter valve interventions. METHODS: Thirty-eight patients with severe symptomatic tricuspid regurgitation were included in this retrospective analysis. Tricuspid annulus (TA) measurements were made during mid-diastole using three-dimensional (3D) transthoracic echocardiographic direct planimetry (TTE_direct) and transesophageal echocardiographic direct planimetry (TEE_direct)...
September 27, 2018: Journal of the American Society of Echocardiography
Y Song, S-C Qin, X Fu, Z-M Jiang, K Chen, X-L Wang, R-F Zhang, Y Liuang, R-F Zhang, Y Liu
OBJECTIVE: To investigate the efficacy of transesophageal echocardiography (TEE) in the treatment of nonvalvular atrial fibrillation with left atrial appendage (LAA) occlusion. PATIENTS AND METHODS: Forty-nine patients with nonvalvular atrial fibrillation were selected from January 2015 to December 2015 to serve as control group, and 49 patients with nonvalvular atrial fibrillation were selected from January 2016 to December 2016 to serve as observation group. Patients in both groups were treated with LAA occlusion...
August 2018: European Review for Medical and Pharmacological Sciences
Tao Cong, Jinping Gu, Alex Pui-Wai Lee, Zhijuan Shang, Yinghui Sun, Qiaobing Sun, Hong Wei, Na Chen, Siyao Sun, Tingting Fu
BACKGROUND: Atrial fibrillation (AF) can result in atrial functional mitral regurgitation (MR), but the mechanism remains controversial. Few data about the relationship between the 3-dimensional morphology of the MV and the degree of MR in AF exist. METHODS: Real-time 3-dimensional transesophageal echocardiography (3D-TEE) of the MV was acquired in 168 patients with AF (57.7% persistent AF), including 25 (14.9%) patients with moderate to severe MR (the MR+ group) and 25 patients without AF as controls...
August 21, 2018: Cardiovascular Ultrasound
Thilo Noack, Kathleen Wittgen, Philipp Kiefer, Fabian Emrich, Matthias Raschpichler, Sarah Eibel, David Holzhey, Martin Misfeld, Friedrich-Wilhelm Mohr, Michael Borger, Joerg Ender, Joerg Seeburger
BACKGROUND:  The aim of this study was to quantify acute mitral valve (MV) geometry dynamic changes throughout the cardiac cycle using three-dimensional transesophageal echocardiography (3D TEE) in patients undergoing surgical MV repair (MVR) with ring annuloplasty and optional neochord implantation. METHODS:  Twenty-nine patients (63 ± 10 years) with severe primary mitral regurgitation underwent surgical MVR using ring annuloplasty with or without neochord implantation...
August 16, 2018: Thoracic and Cardiovascular Surgeon
Verya Daeichin, Deep Bera, Shreyas Raghunathan, Maysam Shabani Motlagh, Zhao Chen, Chao Chen, Emile Noothout, Hendrik J Vos, Michiel Pertijs, Johan G Bosch, Nico de Jong, Martin Verweij
This paper presents the design, fabrication and characterization of a miniature PZT-on-CMOS matrix transducer for real-time pediatric 3-dimensional (3D) transesophageal echocardiography (TEE). This 3D TEE probe consists of a 32 × 32 array of PZT elements integrated on top of an Application Specific Integrated Circuit (ASIC). We propose a partitioned transmit/receive array architecture wherein the 8 × 8 transmitter elements, located at the centre of the array, are directly wired out and the remaining receive elements are grouped into 96 sub-arrays of 3 × 3 elements...
October 2018: Ultrasound in Medicine & Biology
Inês Delgado, Ana Fonte Boa, Ana Filipa Carvalho, Bruno Melica, Pedro Braga, Vasco Gama Ribeiro
The percutaneous MitraClip system is a catheter-based device designed to perform edge-to-edge mitral valve (MV) leaflet repair at the site of regurgitation. MitraClip implantation is an alternative procedure in patients at high surgical risk with symptomatic severe mitral regurgitation (MR) who are not candidates for MV repair/replacement due to their degree of comorbidity and associated high mortality risk. The procedure is guided by 3-dimensional (3D) transesophageal echocardiography (TEE) and fluoroscopy...
August 2018: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
Sonia A El-Saiedi, Hala M Agha, Mohamed F Shaltoot, Hayat H Nassar, Amal M El Sisi, Wael A Attia, Yasser M Sedky
Objective: Real-time three-dimensional echocardiography, using both reconstruction methods and RT3D, has been used as an extra helping tool in several forms of congenital heart diseases. Our aim was to understand the relation of the ASD device to all surrounding structures by 3-dimensional echocardiography (3D). Methods: This prospective study included 37 patients diagnosed as ASD secundum by transthoracic (TTE) and transesophageal echocardiography (TEE) referred for transcatheter closure from October 2013 to July 2016...
July 2018: Journal of the Saudi Heart Association
Tasneem Z Naqvi
Transesophageal echocardiography (TEE) plays a significant role during transcatheter aortic valve implantation (TAVR). 2DTEE allows assessment of anatomy of the aortic valve, aortic root, left ventricular (LV) outflow tract, severity of the aortic valve stenosis (AS), and the presence and severity of other valve stenosis and regurgitation. Left and right ventricular size and global function as well as cardiac hemodynamics pre and post TAVR and LV regional wall motion can be assessed. Three-dimensional (3D) imaging adds significantly via accurate measurement of aortic annulus that helps select the appropriate valve size...
July 2018: Echocardiography
Begum Uygur, Omer Celik, Fethi Emre Ustabasioglu, Okan Akinci, Mehmet Erturk
AIM: Rheumatic heart disease is a common cause of valvular disease, especially in developing countries. Echocardiography is the gold standard investigation modality for cardiac valves. In rheumatic mitral stenosis (MS), three-dimensional transesophageal echocardiography (3D TEE) provides better alignment of the image plane at the mitral tips and more accurate and reproducible planimetric measurement of mitral valve area (MVA). Cardiac magnetic resonance (CMR) is a new method that provides evaluation of cardiac anatomy and function noninvasively...
October 2018: Echocardiography
Charlotte E Johnson, Elaine A Dunlop, Sara Seifan, Henry D McCann, Trevor Hay, Geraint J Parfitt, Ashley T Jones, Peter J Giles, Ming H Shen, Julian R Sampson, Rachel J Errington, D Mark Davies, Andrew R Tee
Cancer cells lose homeostatic flexibility because of mutations and dysregulated signaling pathways involved in maintaining homeostasis. Tuberous Sclerosis Complex 1 (TSC1) and TSC2 play a fundamental role in cell homeostasis, where signal transduction through TSC1/TSC2 is often compromised in cancer, leading to aberrant activation of mechanistic target of rapamycin complex 1 (mTORC1). mTORC1 hyperactivation increases the basal level of endoplasmic reticulum (ER) stress via an accumulation of unfolded protein, due to heightened de novo protein translation and repression of autophagy...
July 6, 2018: Oncogene
Pei-Ni Jone, Jenny E Zablah, Dale A Burkett, Michal Schäfer, Neil Wilson, Gareth J Morgan, Michael Ross
BACKGROUND: Radiation reduction is desirable in children undergoing cardiac catheterization. Three-dimensional (3D) transesophageal echocardiographic (3D TEE) imaging obviates the need for mental reconstruction of 3D structures from two-dimensional images. Three-dimensional TEE imaging is used in atrial septal defect (ASD) closures. Three-dimensional TEE guidance of right heart catheterization (RHC) without fluoroscopy for ASD closures has not been demonstrated. The aim of this study was to evaluate the feasibility of 3D TEE guidance of RHC in ASD closures and radiation reduction compared with historical control subjects...
September 2018: Journal of the American Society of Echocardiography
Anne-Lise Hachulla, Stéphane Noble, Gabriel Guglielmi, Daniel Agulleiro, Hajo Müller, Jean-Paul Vallée
OBJECTIVES: Correct device sizing for left atrial appendage (LAA) closure remains challenging due to complex LAA shapes. The aim of our study was to investigative the utility of personalized 3D-printed models (P3DPM) of the LAA to guide device size selection. METHODS: Fifteen patients (75.4 ±8.5years) scheduled for LAA closure using an Amulet device underwent cardiac computed tomography (CT). The LAA was segmented by semiautomatic algorithms using Vitrea® software...
June 14, 2018: European Radiology
Rita Leonarda Musci, Cataldo Girasoli, Fabrizio Fumarola, Carlo D'Agostino, Paolo Colonna
In recent years, with an increasing number of central venous access procedures and cardiac implantable electronic device implantation, the incidence of infective endocarditis (IE) has become more prevalent. Two-dimensional transthoracic echocardiography (2D-TTE) and transesophageal echocardiography (TEE) are a key part of the evaluation of IE, but advances in three-dimensional echocardiography have enabled a better spatial resolution and visualization of cardiac structures, allowing the identification of any valvular vegetations, abscesses, or nodules...
April 2018: Journal of Cardiovascular Echography
Zorica Mladenovic, Danijela Vranes, Slobodan Obradovic, Boris Dzudovic, Andjelka Angelkov Ristic, Nenad Ratkovic, Zoran Jovic, Marijan Spasic, Jelena Maric Kocijancic, Predrag Djruic
Unicuspid aortic valve (UAV) is a rare congenital anomaly of aorta associated with a faster progress of valvular dysfunction, aortic dilatation and with necessity for more frequent controls and precise evaluation Asymptomatic 35 year old man had abnormal systolic diastolic murmur on aortic valve during routine examination. Initial diagnostic with transthoracic echocardiography (TTE) supposed bicuspid aortic valve, while three-dimensional transesophageal echocardiography (3D TEE) and multidetector computed tomography defined unicuspid, unicomissural aortic valve with moderate aortic stenosis and regurgitation...
August 2018: Echocardiography
Dan Koto, Masaki Izumo, Takafumi Machida, Kengo Suzuki, Kihei Yoneyama, Tomomi Suzuki, Ryo Kamijima, Yasuyuki Kobayashi, Tomoo Harada, Yoshihiro J Akashi
BACKGROUND: It is unclear how upper septal hypertrophy (USH) affects Doppler-derived left ventricular stroke volume (SV) in patients with AS. The aims of this study were to: (1) validate the accuracy of 3D transesophageal echocardiography (TEE) measurements of the left ventricular outflow tract (LVOT), (2) evaluate the differences in LVOT geometry between AS patients with and without USH, and (3) assess the impact of USH on measurement of SV. METHODS: In protocol 1, both 3D TEE and multi-detector computed tomography were performed in 20 patients with AS [aortic valve area (AVA) ≤ 1...
May 24, 2018: Journal of Echocardiography
Calogera Pisano, Claudia Calia, Alessandro Ricasoli, Oreste Fabio Triolo, Vincenzo Argano
BACKGROUND: Segmental analysis of diseased mitral valves is important to predict a successful surgical valve repair. An assessment was made of the comparative accuracy of intraoperative three-dimensional (3D) and two-dimensional (2D) transesophageal echocardiography (TEE) in the evaluation of mitral valve lesions when compared with intraoperative surgical segmental analysis. METHODS: A total of 42 consecutive patients (12 females, 30 males; mean age 70.5 ± 14 years) with severe mitral valve regurgitation due to degenerative disease and who underwent mitral valve repair was enrolled in the study...
September 2017: Journal of Heart Valve Disease
Caroline Morbach, Diego Bellavia, Stefan Störk, Lissa Sugeng
BACKGROUND: Mitral regurgitation in ischemic heart disease (IMR) is a strong predictor of outcome but until now, pathophysiology is not sufficiently understood and treatment is not satisfying. We aimed to systematically evaluate structural and functional mitral valve leaflet and annular characteristics in patients with IMR to determine the differences in geometric and dynamic changes of the MV between significant and mild IMR. METHODS: Thirty-seven patients with IMR (18 mild (m)MR, 19 significant (moderate+severe) (s)MR) and 33 controls underwent TEE...
May 10, 2018: BMC Cardiovascular Disorders
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