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Li Zhou, Shao-Bin Wang, Shu-Guang Chen, Qiang Qu, Jing-An Rui
BACKGROUND: Alanine aminotransferase (ALT), aspartate aminotransferase (AST), and AST to ALT ratio (AAR) were shown to be associated with prognosis in some groups of hepatocellular carcinoma (HCC). However, their clinicopathologic and prognostic roles in HCC patients with B-type hepatitis-associated cirrhosis (HBAC) have not been comprehensively investigated. The present study aimed to address the issues. METHODS: A total of 125 patients with HCC and HBAC after radical hepatectomy were included...
October 1, 2018: Clinical Laboratory
Shukang He, Wei Wang, Haijian Zhao, Chuanbao Zhang, Falin He, Kun Zhong, Shuai Yuan, Zhiguo Wang
BACKGROUND: This study observed and analyzed the internal quality control (IQC) of cystatin C (CysC) so that we can have overall knowledge about imprecision levels in Chinese medical laboratories. METHODS: Using the software developed by the National Center for Clinical Laboratories (NCCL), we can get the IQC information of CysC from 2014 to 2017. Then the proportion of laboratories meeting five quality specifications (pass rates) were calculated and the current CVs (coefficient of variation) were also compared among subgroups and years...
October 1, 2018: Clinical Laboratory
Alan D Rogol, Lindsay Parks Pieper
This report illustrates the links between history, sport, endocrinology, and genetics to show the ways in which historical context is key to understanding the current conversations and controversies about who may compete in the female category in elite sport. The International Association of Athletics Federations (IAAF) introduced hyperandrogenemia regulations for women's competitions in 2011, followed by the International Olympic Committee (IOC) for the 2012 Olympics. The policies concern female athletes who naturally produce higher-than-average levels of testosterone and want to compete in the women's category...
October 18, 2018: Hormone Research in Pædiatrics
Peter M Elias, Joan S Wakefield, Mao-Qiang Man
We compare here the principal characteristics of over-the-counter moisturizers with physiologic lipid-based barrier repair therapy. Moisturizers are standard ancillary therapy for anti-inflammatory skin disorders, like atopic dermatitis (AD), and can attenuate the emergence of AD, the initial step in the "atopic march." But not all moisturizers are beneficial; some can make skin function worse, and can even induce inflammation, possibly accounting for the frequent occurrence of "sensitive skin" in women...
October 18, 2018: Skin Pharmacology and Physiology
Laurent Tatu, Julien Bogousslavsky
The issue of First World War shell shock has been documented mainly from a medical perspective. Many medical texts dealing with war psychoneuroses and their aggressive treatments, such as electrotherapy, were published during the war. Accounts from shell-shocked soldiers are rare. Nevertheless, shell shock was described from a non-medical point of view by a few writers who had undergone or witnessed this pathology. Their texts deal mainly with the psychiatric forms, the most striking ones, but also with the more common concepts of commotion, emotion and pathological fear...
2018: Frontiers of Neurology and Neuroscience
Claire Maingon, Laurent Tatu
Many artists were involved in the First World War. Some of them were mobilized, like millions of soldiers, others enlisted to fight on the battlefield. The stories of writers who returned neurologically wounded from the war, such as Guillaume Apollinaire (1880-1918) or Blaise Cendrars (1887-1961), are well-known. The cases of painters and sculptors who suffered from First World War neurological wounds are scarce. Nevertheless, their injuries led to intense modifications of artistic practice. We detail four examples of artists whose creative mind was impacted by their First World War neurological wounds or diseases...
2018: Frontiers of Neurology and Neuroscience
Elisabete Castelon Konkiewitz, Edward Benjamin Ziff
In this essay, we propose an association between Franz Kafka's novel, The Trial, and phenomenological and neurobiological processes in schizophrenia. We begin by presenting a summary of the plot, pointing to some of its remarkable literary aspects. We next compare the mental processes of dissociation, disorientation and delusion as represented in the novel with phenomenological processes that take place in the prodromal states of schizophrenia. We discuss how such disorders of the self and disorders of thought, both crucial aspects of the schizophrenic experience, appear in The Trial and in other literary and private writings by Franz Kafka...
2018: Frontiers of Neurology and Neuroscience
Yi-Ju Chen, Ling Yeung, Chi-Chin Sun, Chien-Chieh Huang, Kuo-Su Chen, Yi-Hsuan Lu
BACKGROUND: Age-related macular degeneration (AMD) is an important cause of blindness in aged people. Chronic kidney disease (CKD) was reported to be associated with a higher risk of AMD. However, supporting evidence was inconsistent between studies. This work intends to examine whether a positive association exists between CKD and AMD by systematic review and meta-analysis. METHODS: A systematic search of electronic databases (Medline, PubMed, Cochrane and EMBASE) and reference lists on June 2017...
October 18, 2018: American Journal of Nephrology
Nicoletta Caputi, Daniel Birnbaum, François Boller
Thomas Mann (1875-1955) is considered one of the most influential writers of the late nineteenth and early twentieth century. In addition to his novels and essays, he was well known for his criticisms of the Nazi party, and particularly against the racial nationalism promoted by Adolf Hitler after the First World War, as well as for his depiction of diseases. Here, we provide a quick sketch of Mann's life and his relationship with nineteenth to twentieth century German society. We then proceed to describe how Mann became interested in diseases, how he used the diseases as metaphors, and his specific contribution to the field of neurology...
2018: Frontiers of Neurology and Neuroscience
Montserrat G Delgado, Julien Bogousslavsky
Psychopathology has been closely related with artists. A link between creativity and a tendency to affective disorders has become widely accepted. Several studies have shown that artists suffer disproportionately high rates of mood disorders, particularly manic depression and major depression. The famous twentieth century Spanish artist Joan Miró suffered from depression during the entirety of his life, as was recognized by some authors in private letters. The artist worked using several styles, as well as in ceramics and sculpture...
2018: Frontiers of Neurology and Neuroscience
Julien Bogousslavsky, Laurent Tatu
Édouard Manet (1832-1883) is considered the "father" of impressionism and even of twentieth century modern art. Manet's genius involved getting away from the classical narrative or historical topics and replacing them by the banality of daily life. Technically, he erased volumes into flat two-dimensional coloured planes, and distorted conventional perspective with often gross brushstrokes intentionally giving an "unfinished" aspect to the work. It is little known that Manet had a very painful second part of his life, due to excruciating limb and chest pains, which developed in parallel with proprioceptive ataxia and gait imbalance...
2018: Frontiers of Neurology and Neuroscience
Laura Hannemann, Calin Rares Lucaciu, Sapna Sharma, Thomas Rattei, Klaus F X Mayer, Alfons Gierl, Monika Frey
In the plant kingdom beta-glucosidases (BGLUs) of the glycosidase hydrolase family 1 have essential function in primary metabolism and are particularly employed in secondary metabolism. They are essential for activation in two-component defence systems based on stabilisation of reactive compounds by glycosylation. Based on de novo assembly we isolated and functionally characterised BGLUs expressed in leaves of Lamium galeobdolon (LgGLUs). LgGLU1 could be assigned to hydrolysis of the benzoxazinoid GDIBOA (2,4-dihydroxy-1,4-benzoxazin-3-one glucoside)...
October 15, 2018: Phytochemistry
Elizabeth G Radke, Joseph M Braun, John D Meeker, Glinda S Cooper
OBJECTIVE: We performed a systematic review of the epidemiology literature to identify the male reproductive effects associated with phthalate exposure. DATA SOURCES AND STUDY ELIGIBILITY CRITERIA: Six phthalates were included in the review: di(2-ethylhexyl) phthalate (DEHP), diisononyl phthalate (DINP), dibutyl phthalate (DBP), diisobutyl phthalate (DIBP), butyl benzyl phthalate (BBP), and diethyl phthalate (DEP). The initial literature search (of PubMed, Web of Science, and Toxline) included all studies of male reproductive effects in humans, and outcomes were selected for full systematic review based on data availability...
October 15, 2018: Environment International
J V B Moura, C Luz-Lima, G S Pinheiro, P T C Freire
Temperature-dependent Raman spectroscopic study has been performed on scheelite-type sodium‑cerium molybdate - NaCe(MoO4 )2 - in the temperature range 113-873 K. This study provides phonon properties of NaCe(MoO4 )2 , which are very important to understand the mechanism governing eventual phase transitions undergone by the structure, since phonons are very sensitive to structural changes. The ambient scheelite phase remains stable in a low-temperature range (113-293 K), and no relevant modification is observed in the Raman spectra...
October 12, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
Emily Kroshus, Christine M Baugh, William P Meehan, Kasisomayajula Viswanath
BACKGROUND: There is increasing focus on the number of concussions after which an athlete should discontinue participating in contact or collision sports. This is a clinically subjective and, in some cases, a preference-sensitive decision. PURPOSE: Our goal was to assess whether there is personal subjectivity in when athletic trainers (ATs) discuss the possibility of sport retirement post-concussion with athletes. METHODS: A national sample of ATs who provide clinical care to college athletes completed a questionnaire (n = 677, 34% response rate)...
July 31, 2018: Social Science & Medicine
Huy Q Dang, Huong T Le, Linh T H Ngo
INTRODUCTION: Although totally endoscopic surgery (TES) has been widely applied for the treatment of atrial septal defect (ASD), small children receive few benefits from this technique due to risks of the femoral cannulation. CASE PRESENTATION: A 23-month-old boy, weighing 10.5 kg, with the diagnosis of sinus venosus ASD underwent successful repair by TES. We performed this surgery through 4 small trocars (one 12 mm trocar and three 5 mm trocars), without robotic assistance...
October 10, 2018: International Journal of Surgery Case Reports
Erin Ussery, Kristin N Bridges, Zacharias Pandelides, Andrea E Kirkwood, Dario Bonetta, Barney J Venables, John Guchardi, Douglas Holdway
Metformin is one of the most prevalent pharmaceuticals in both surface and waste waters, yet little is known about the bioavailability and/or effects of developmental exposure on early life stage (ELS) fish. Here, we demonstrate that embryo-larval stages of medaka are capable of taking up metformin from the aquatic environment, provided exposure occurs prior to chorion hardening (∼6-hpf). Once transferred to clean water, ELS medaka are able to completely depurate metformin in <24-hours. Furthermore, ELS medaka exposed to a range of relevant concentrations of waterborne metformin (from 6 hpf through 28-days post hatch) had significantly reduced growth metrics, altered metabolomes, and changes in the expression of genes associated with cell growth...
October 9, 2018: Aquatic Toxicology
Evert-Ben van Veen
Insights into the incidence and survival of cancer, the influence of lifestyle and environmental factors and the interaction of treatment regimens with outcomes are hugely dependent on observational research, patient data derived from the healthcare system and from volunteers participating in cohort studies, often non-selective. Since 25th May 2018, the European General Data Protection Regulation (GDPR) applies to such data. The GDPR focusses on more individual control for data subjects of 'their' data. Yet, the GDPR was preceded by a long debate...
October 15, 2018: European Journal of Cancer
Michalea Rozalia, Stathopoulou Konstantina, Polychronopoulos Panagiotis, Benaki Dimitra, Mikros Emmanuel, Aligiannis Nektarios
ETHNOPHARMACOLOGICAL RELEVANCE: On the basis of the relevant reference in the poem Theriaca of the ancient Greek physician Nicander and its traditional use, Paeonia parnassica was selected for the evaluation of two extracts obtained from the roots and aerial parts to inhibit hydrolytic enzymes involved in snake envenomation. The secondary metabolites which contribute to these activities were detected through a novel HeteroCovariance NMR based approach. Afterwards these ingredients were isolated, identified and evaluated for their inhibitory potency...
October 15, 2018: Journal of Ethnopharmacology
Lude Zhu, Peiru Wang, Guolong Zhang, Linglin Zhang, Xiaojing Liu, Chan Hu, Xiaoqin Yang, Ronald Sroka, Zhongxia Zhou, Xiuli Wang
BACKGROUND: Conventional photodynamic therapy (C-PDT) is an effective treatment for actinic keratoses (AKs) in Asia, with some unmet needs. Severe PDT-associated pain results in low treatment willingness. Daylight photodynamic therapy (DL-PDT) is a more simple and tolerable treatment that has the same efficacy as C-PDT in Europe. However, few studies have been conducted with Asian patients. OBJECTIVE: To evaluate the efficacy and safety of DL-PDT vs. C-PDT for treating AK patients in China...
October 15, 2018: Photodiagnosis and Photodynamic Therapy
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