Read by QxMD icon Read


N Arias Ramos, M D Calvo Sánchez, T Fernández-Villa, M A Ovalle Perandones, D Fernández García, P Marqués-Sánchez
BACKGROUND: Multiple studies have shown the social consequences of suffering overweight, with social exclusion or isolation as some of the most important. In order to study the social patterns among adolescents, we have set as objectives to analyse the position of the individual within their network from a sociocentric perspective, comparing the relational pattern of the adolescents suffering from overweight with those who are normal weight. METHOD: This was a cross-sectional descriptive study using logistic regression and social network analysis...
August 15, 2018: Pediatric Obesity
Jiayi Wang, Wen Liu, Zhenzhen Zhao, Yan Zhang, Bing Luo
BACKGROUND/AIMS: Aquaporins are widely expressed in a variety of cancers and were found to play an important role in cell migration, angiogenesis, tumor formation, and tumor development. Thus, they have been proposed as a potential biomarker for some cancers. Accordingly, we analyzed the association between a single-nucleotide polymorphism locus of aquaporin 3 (rs2231231) and Epstein-Barr virus (EBV)-associated nasopharyngeal carcinoma (EBVaNPC), lymphoma (EBVaL), and gastric carcinoma in China...
August 15, 2018: Intervirology
Maurizio Pompili, Luana Lionetto, Martina Curto, Alberto Forte, Denise Erbuto, Franco Montebovi, Maria Elena Seretti, Isabella Berardelli, Gianluca Serafini, Marco Innamorati, Mario Amore, Ross J Baldessarini, Paolo Girardi, Maurizio Simmaco
BACKGROUND: Some previous studies found decreased concentrations of L-tryptophan (TRY) and increased L-kynurenine (KYN), or its metabolites, in the body fluids of subjects with major depressive disorder (MDD), sometimes in association with suicidal behavior. Such changes might indicate a shift of TRY away from serotonin production, possibly via the effects of inflammatory peptides which activate indoleamine-2,3-dioxygenase. However, these findings have been inconsistent and require replication...
August 15, 2018: Neuropsychobiology
Bin Zhu, Dong-Rong Yu, Ji-Cheng Lv, Yi Lin, Qiang Li, Jia-Zhen Yin, Yuan-Yuan Du, Xuan-Li Tang, Li-Chan Mao, Qiu-Fen Li, Yue Sun, Ling Liu, Xian-Fa Li, Dan Fei, Xin-Yi Wei, Cai-Feng Zhu, Xiao-Xia Cheng, Hong-Yu Chen, Yong-Jun Wang
BACKGROUND: The role of serum uric acid (SUA) level in the progression of Immunoglobulin A nephropathy (IgAN) remains controversial. METHODS: In a cohort of 1,965 cases with biopsy-proven IgAN, we examined the associations of SUA concentration with the primary outcome of a composite of all-cause mortality or kidney failure (defined as a reduction of estimated glomerular filtration rate [eGFR] by 40% from baseline, requirements for dialysis and transplantation), or the outcome of kidney failure alone, assessed using Cox and logistic regression models, respectively, with adjustment for confounders...
August 15, 2018: American Journal of Nephrology
John T Daugirdas
BACKGROUND: Changes in plasma volume during hemodialysis are complex and have been shown to depend on the rate of fluid removal and the degree of fluid overload. We examined changes in total protein concentration during and shortly after a dialysis treatment in archived data from the HEMO study. METHODS: During follow-up months 4 and 36 of the HEMO study, additional blood samples were obtained during a typical dialysis session at 30 and 60 min after dialysis. In 315 studies from 282 patients where complete data were available, we calculated the concentration change in total protein and compared it to the modeled change in both total body water and extracellular fluid space as derived from 2-pool urea kinetic modeling...
August 15, 2018: American Journal of Nephrology
W David Hill, Sarah E Harris, Ian J Deary
Intelligence, as measured by standardised tests of cognitive function, such as IQ-type tests, is predictive of psychiatric diagnosis and psychological wellbeing. Using genome-wide association study (GWAS) data, a measure of the shared genetic effect across traits, can be quantified; because this can be done across samples, the confounding effects of psychiatric diagnosis do not influence the magnitude of these relationships. It is now known that there are genetic effects that act across intelligence and psychiatric diagnoses, which provide a partial explanation for the phenotypic link between intelligence and mental health...
July 24, 2018: Current Opinion in Psychology
Jessica P Gillung, Shaun L Winterton, Keith M Bayless, Ziad Khouri, Marek L Borowiec, David Yeates, Lynn S Kimsey, Bernhard Misof, Seunggwan Shin, Xin Zhou, Christoph Mayer, Malte Petersen, Brian M Wiegmann
The onset of phylogenomics has contributed to the resolution of numerous challenging evolutionary questions while offering new perspectives regarding biodiversity. However, in some instances, analyses of large genomic datasets can also result in conflicting estimates of phylogeny. Here, we present the first phylogenomic scale study of a dipteran parasitoid family, built upon anchored hybrid enrichment and transcriptomic data of 240 loci of 43 ingroup acrocerid taxa. A new hypothesis for the timing of spider fly evolution is proposed, wielding recent advances in divergence time dating, including the fossilized birth-death process to show that the origin of Acroceridae is younger than previously proposed...
August 12, 2018: Molecular Phylogenetics and Evolution
Xiaozhen Yang, Genyong Huang, Minjie Xu, Cong Zhang, Yongxu Cheng, Zhigang Yang
Serotonin (5-HT) regulates numerous physiological functions and processes, such as light adaptation, food intake and ovarian maturation, and plays the role through 5-HT receptors. To our knowledge, this is the first study to isolate and characterize the serotonin receptor 7 (5-HT7 receptor) cDNA encoded in Eriocheir sinensis, an economically important aquaculture species in China, by performing rapid-amplification of cDNA ends. The full-length of 5-HT7 receptor gene cDNA is 2328 bp and encodes a polypeptide with 590 amino acids that are highly homologous with other crustaceans 5-HT7 receptor genes...
August 12, 2018: Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology
Michael J Andres, Eric E Pulis, Stephen S Curran, Robin M Overstreet
Megasolena mikra sp. nov. is described from the queen angelfish, Holacanthus ciliaris (Linnaeus), off Florida, USA. The new species can be differentiated from all other species of Megasolena Linton, 1910 except Megasolena littoralis Muñoz, George-Nascimento, and Bray, 2017 in possessing testes that are smaller in diameter than the ovary. The new species can be differentiated from M. littoralis in lacking tegumental spines and possessing oral sucker papillae. Molecular data are provided for two species each of Cadenatella Dollfus, 1946, Hapladena Linton, 1910, and Megasolena Linton, 1910...
August 12, 2018: Parasitology International
Chunhu Gu, Tian Li, Shuai Jiang, Zhi Yang, Jianjun Lv, Wei Yi, Yang Yang, Minfeng Fang
AMP-activated protein kinase (AMPK) is a pivotal regulator of some endogenous defensive molecules in various pathological processes, particularly myocardial ischemia (MI), a high risk of myocardial infarction. Thereby it is of great significance to explore the inherent mechanism between AMPK and myocardial infarction. In this review, we first introduce the structure and role of AMPK in the heart. Next, we introduce the mechanisms of AMPK in the heart; followed by the energy regulation of AMPK in MI. Lastly, the attention will be expanded to some potential directions and further perspectives...
August 12, 2018: Ageing Research Reviews
Esra Nurten Yer, Mehmet Cengiz Baloglu, Sezgin Ayan
Heat shock proteins (Hsps) play a key role for regulation of the changes during different stress conditions including salinity, drought, heavy metal and extreme temperature. Molecular based studies on the response mechanisms of forest trees to abiotic stresses started in 2006 when Populus trichocarpa genome sequence was completed as a model tree species. In recent years, bioinformatic analyzes have been carried out to determine functional gene regions of tree species. In this study, sHsp, Hsp40, Hsp60, Hsp90 and Hsp100 gene family members were identified in poplar genome...
August 12, 2018: Gene
Michelle Meyer, Asuka Yoshida, Palaniappan Ramanathan, Erica Ollmann Saphire, Peter L Collins, James E Crowe, Siba Samal, Alexander Bukreyev
Comparative immune response profiling is important for selecting next-generation vaccines. We comprehensively evaluated the antibody responses from a panel of nine respiratory vaccines against Ebola virus (EBOV) derived from human and avian paramyxoviruses expressing EBOV glycoprotein (GP). Most vaccines were protective in guinea pigs but yielded antibody repertoires that differed in proportion targeting key antigenic regions, avidity, neutralizing antibody specificities, and linear epitope preferences. Competition studies with monoclonal antibodies from human survivors revealed that some epitopes in GP targeted for neutralization were vector dependent, while EBOV-neutralizing titers correlated with the response magnitude toward the receptor-binding domain and GP1/GP2 interface epitopes...
August 14, 2018: Cell Reports
Natalia A Kuzmina, Patrick Younan, Pavlo Gilchuk, Rodrigo I Santos, Andrew I Flyak, Philipp A Ilinykh, Kai Huang, Ndongala M Lubaki, Palaniappan Ramanathan, James E Crowe, Alexander Bukreyev
Some monoclonal antibodies (mAbs) recovered from survivors of filovirus infections can protect against infection. It is currently unknown whether natural infection also induces some antibodies with the capacity for antibody-dependent enhancement (ADE). A panel of mAbs obtained from human survivors of filovirus infection caused by Ebola, Bundibugyo, or Marburg viruses was evaluated for their ability to facilitate ADE. ADE was observed readily with all mAbs examined at sub-neutralizing concentrations, and this effect was not restricted to mAbs with a particular epitope specificity, neutralizing capacity, or subclass...
August 14, 2018: Cell Reports
Thao V Nguyen, Andrea C Alfaro, Fabrice Merien, Tim Young, Roffi Grandiosa
Massive mortalities due to pathogens are routinely reported in bivalve cultivation that have significant economic consequences for the global aquaculture industry. However, host-pathogen interactions and infection mechanisms that mediate these interactions are poorly understood. In addition, gender-specific immunological responses have been reported for some species, but the reasons for such differences have not been elucidated. In this study, we used a GC/MS-based metabolomics platform and flow cytometry approach to characterize metabolic and immunological responses in haemolymph of male and female mussels (Perna canaliculus) experimentally infected with Vibrio sp...
August 12, 2018: Journal of Invertebrate Pathology
Chiara Monachesi, Lucia Zampini, Lucia Padella, Rita Lucia Marchesiello, Tiziana Galeazzi, Lucia Santoro, Carlo Catassi, Enrico Gasparrini, Virgilio Paolo Carnielli, Nicola Volpi, Agata Fiumara, Daniela Concolino, Rosella Tomanin, Giovanni Valentino Coppa, Orazio Gabrielli
BACKGROUND: In total, 930 urine samples obtained on 2nd and 3rd day from birth have been analyzed for the early diagnosis of Mucopolysaccharidoses. METHODS: Dimethylmethylene blue (DMB) assay and one-dimensional electrophoresis were performed in all urine samples. Agarose gel electrophoresis, before and after treatment with chondroitinase ABC and heparinases, was used for a comprehensive characterization. RESULTS: Out of 930 urine samples 7 showed anomalous electrophoretic pattern; 5 of them had high GAG levels by DMB test...
August 12, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
Maulana Antiyan Empitu, Ika Nindya Kadariswantiningsih, Masashi Aizawa, Katsuhiko Asanuma
In many cells and tissues including the glomerular filtration barrier (GFB), scaffold proteins are critical in optimizing signal transduction by enhancing structural stability and functionality of their ligands. Recently, mutations in scaffold protein Membrane-Associated Guanylate Kinase Inverted 2 (MAGI-2) encoding gene were identified among the etiology of steroid-resistant nephrotic syndrome (SRNS). MAGI-2 interacts with core proteins of multiple pathways such as TGF-β signaling, planar cell polarity pathway, and Wnt/β-catenin signaling in podocyte and slit diaphragm...
August 15, 2018: American Journal of Physiology. Renal Physiology
Pamela L Ramage-Morin, Marc Gosselin
BACKGROUND: Health and safety legislation is designed to protect workers from hazards, including excessive noise. However, some workers are not required to use hearing protection when exposed to loud noise and may be vulnerable to adverse outcomes, including hearing difficulties and tinnitus. DATA AND METHODS: Data for 19- to 79-year-olds (n=6,571) were collected from 2012 through 2015 as part of the Canadian Health Measures Survey. People exposed to loud workplace noise were defined as those who had to raise their voices to communicate at arm's length...
August 15, 2018: Health Reports
Jeroen Aeles, Ilse Jonkers, Sofie Debaere, Christophe Delecluse, Benedicte Vanwanseele
The aim of this study was to compare young and adult sprinters on several biomechanical parameters that were previously highlighted as performance-related and to determine the behaviour of several muscle-tendon units (MTU) in the first stance phase following a block start in sprint running. The ground reaction force (GRF) and kinematic data were collected from 16 adult and 21 young well-trained sprinters. No difference between the groups was found in some of the previously highlighted performance-related parameters (ankle joint stiffness, the range of dorsiflexion and plantar flexor moment)...
June 2018: Royal Society Open Science
Kristin M Hutchins
The design, synthesis and property characterization of new functional materials has garnered interest in a variety of fields. Materials that are capable of recognizing and binding with small molecules have applications in sensing, sequestration, delivery and property modification. Specifically, recognition of pharmaceutical compounds is of interest in each of the aforementioned application areas. Numerous pharmaceutical compounds comprise functional groups that are capable of engaging in hydrogen-bonding interactions; thus, materials that are able to act as hydrogen-bond receptors are of significant interest for these applications...
June 2018: Royal Society Open Science
Hany M Hassanin, Rabah A T Serya, Wafaa R Abd Elmoneam, Mai A Mostafa
A series of novel pyranoquinolinone-based Schiff's bases were designed and synthesized. They were evaluated for topoisomerase IIβ (TOP2B) inhibitory activity, and cytotoxicity against breast cancer cell line (MCF-7) for the development of novel anticancer agents. A molecular docking study was employed to investigate their binding and functional properties as TOP2B inhibitors, using the Discovery Studio 2.5 software, where they showed very interesting ability to intercalate the DNA-topoisomerase complex. Compounds 2a , 2c and 2f showed high docking score values (82...
June 2018: Royal Society Open Science
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"