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miR-181a

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https://www.readbyqxmd.com/read/28814760/mir-181a-involves-in-the-hippocampus-dependent-memory-formation-via-targeting-prkaa1
#1
Sun-Fu Zhang, Jun-Chen Chen, Jing Zhang, Jian-Guo Xu
Post-transcriptional gene regulation by microRNAs (miRNAs) is involved in memory formation. However, the roles of individual miRNAs in these processes remain largely unknown. In this study, we want to clarify the role of miR-181a in hippocampus-dependent memory formation. A transient increase in miR-181a expression was observed after conditioned fear conditioning (CFC) and object location task (OLT) training. Selective overexpression or inhibition of miR-181a in the dorsal hippocampus (DH) via the injection of a miR-181a agomir or antagomir enhanced or impaired the CFC- and OLT-dependent memory formation, respectively...
August 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28769921/microrna-181-variants-regulate-t-cell-phenotype-in-the-context-of-autoimmune-neuroinflammation
#2
Samira Ghorbani, Farideh Talebi, Wing Fuk Chan, Farimah Masoumi, Mohammed Vojgani, Christopher Power, Farshid Noorbakhsh
BACKGROUND: Recent studies have revealed that multiple sclerosis (MS) lesions have distinct microRNA (miRNA) expression profiles. miR-181 family members show altered expression in MS tissues although their participation in MS pathogenesis remains uncertain. Herein, we investigated the involvement of miR-181a and miR-181b in the pathogenesis of MS and its animal model, experimental autoimmune encephalomyelitis (EAE). METHODS: miR-181a and -b levels were measured in the central nervous system (CNS) of patients with MS and mice with EAE as well as relevant leukocyte cultures by real-time RT-PCR...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28762332/lncrna-neat1-promotes-proliferation-and-invasion-via-targeting-mir-181a-5p-in-non-small-cell-lung-cancer
#3
ShiDong Li, JiaMei Yang, Yubing Xia, QingXia Fan, Kun-Peng Yang
Long non-coding RNAs (lncRNAs) have been implicated in various biological processes and pathological conditions, including tumorigenesis. However, the exact roles of NEAT1 and its underlying mechanisms in non-small cell lung cancer (NSCLC) remain largely unclear. In the present study, lncRNA NEAT1 was detected to be significantly upregulated in NSCLC tissues and closely associated with advanced TNM stages, lymph node metastasis, distant metastasis and poor prognosis. Further experiments revealed that lncRNA NEAT1 silencing inhibited cell proliferation and invasion in vitro...
July 25, 2017: Oncology Research
https://www.readbyqxmd.com/read/28748390/mir-27b-3p-mir-181a-1-3p-and-mir-326-5p-are%C3%A2-involved-in-the-inhibition-of-macrophage-activation-in-chronic-liver-injury
#4
Weiyang Li, Na Chang, Lei Tian, Jingjing Yang, Xiaofang Ji, Jieshi Xie, Lin Yang, Liying Li
Macrophages are central players in inflammation, which leads to liver injury. It has been reported that continuous macrophage activation initiates this process. Our previous data show that the anti-inflammatory factor, 15-deoxy-Δ(12, 14)-prostaglandin J2 (15d-PGJ2), inhibits bone marrow (BM)-derived macrophage (BMM) migration and inflammatory cytokine production. However, the underlying mechanism of 15d-PGJ2 inhibited BMM activation is still unclear. Here, we evaluate the role of 15d-PGJ2/PPARγ axis in BMM activation...
July 26, 2017: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://www.readbyqxmd.com/read/28747184/meg2-is-regulated-by-mir-181a-5p-and-functions-as-a-tumour-suppressor-gene-to-suppress-the-proliferation-and-migration-of-gastric-cancer-cells
#5
Zhijian Liu, Feng Sun, Yeting Hong, Yanqing Liu, Min Fen, Kai Yin, Xiaolong Ge, Feng Wang, Xi Chen, Wenxian Guan
BACKGROUND: Protein-tyrosine phosphatase MEG2 (MEG2) is a classic tyrosine-specific protein tyrosine phosphatase (PTP). It has been reported that MEG2 participates in the carcinogenesis of the breast and liver. However, functions of MEG2 in gastric cancer remain poorly understood. METHODS: We examined the expression of MEG2 protein by western blotting and that of miR-181a-5p by qRT-PCR. We used bioinformatic analyses to search for miRNAs that potentially target MEG2...
July 26, 2017: Molecular Cancer
https://www.readbyqxmd.com/read/28733034/decreased-expression-of-mir-150-mir146a-and-mir424-in-type-1-diabetic-patients-association-with-ongoing-islet-autoimmunity
#6
Guofeng Wang, Yong Gu, Ning Xu, Mei Zhang, Tao Yang
BACKGROUND: Recent studies revealed altered miRNAs profiling in patients with autoimmune diseases, including type 1 diabetes (T1D). Here, we conducted an observational study and examined the expression levels of these five miRNAs (miR-150,miR-146a,miR-424,miR-181a and miR-142-3P) in peripheral blood mononuclear cells (PBMCs) from T1D patients. METHODS: PBMCs were obtained from T1D cohorts (n = 78), type 2 diabetes (T2D, n = 46) and healthy control subjects (n = 56)...
July 18, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28732737/microrna-181a-and-its-target-smad-7-as-potential-biomarkers-for-tracking-child-acute-lymphoblastic-leukemia
#7
Marwa Nabhan, Manal L Louka, Eman Khairy, Fathy Tash, Randa Ali-Labib, Safinaz El-Habashy
Acute lymphoblastic leukemia (ALL) is the most common pediatric hematologic tumor. MiR-181a was expected to have a role in the development of hematological malignancies; it might act as tumor suppressor or oncogene. Smad7 was selected as miR-181a target pair. It is a negative regulator for the TGF-β1 signaling pathway. In this study, relative expression levels of miR-181a by quantitative reverse transcriptase polymerase chain reaction (qRT-PCR), both Smad 7 and TGF β1 proteins levels by enzyme linked immunosorbent assay (ELISA) were all measured in serum of 60 child, 30 with ALL and 30 age and sex matched healthy child as control group...
July 18, 2017: Gene
https://www.readbyqxmd.com/read/28730334/mir-181a-2-downregulates-the-e3-ubiquitin-ligase-cul4a-transcript-and-promotes-cell-proliferation
#8
Venkateshwarlu Bandi, Sudhakar Baluchamy
MiR-181a-2 plays a major role in cell proliferation both positively and negatively depending on tissue type by targeting several regulators 3'UTR regions. We have predicted several targets for miR-181a-2 through computational approaches and characterized one its interesting target, CUL4A, an E3 ubiquitin ligase. CUL4A regulates diverse functions in the cells including DNA repair, DNA replication, cell cycle, genomic stability through polyubiquitination of target proteins. Deregulation of both miR-181a-2 and CUL4A are reported in many cancerous cells, but the functional link between them is unknown...
August 2017: Medical Oncology
https://www.readbyqxmd.com/read/28717596/phenotypic-and-microrna-transcriptomic-profiling-of-the-mda-mb-231-spheroid-enriched-cscs-with-comparison-of-mcf-7-microrna-profiling-dataset
#9
Lily Boo, Wan Yong Ho, Norlaily Mohd Ali, Swee Keong Yeap, Huynh Ky, Kok Gan Chan, Wai Fong Yin, Dilan Amila Satharasinghe, Woan Charn Liew, Sheau Wei Tan, Soon Keng Cheong, Han Kiat Ong
Breast cancer spheroids have been widely used as in vitro models of cancer stem cells (CSCs), yet little is known about their phenotypic characteristics and microRNAs (miRNAs) expression profiles. The objectives of this research were to evaluate the phenotypic characteristics of MDA-MB-231 spheroid-enriched cells for their CSCs properties and also to determine their miRNAs expression profile. Similar to our previously published MCF-7 spheroid, MDA-MB-231 spheroid also showed typical CSCs characteristics namely self-renewability, expression of putative CSCs-related surface markers and enhancement of drug resistance...
2017: PeerJ
https://www.readbyqxmd.com/read/28711463/modulation-of-atlantic-salmon-mirnome-response-to-sea-louse-infestation
#10
REVIEW
Valentina Valenzuela-Muñoz, Beatriz Novoa, Antonio Figueras, Cristian Gallardo-Escárate
MicroRNAs are non-coding RNA that plays a crucial role in post-transcriptional regulation and immune system regulation. On other hand, sea lice are prevalent parasites that affect salmon farming, generating different degrees of immune suppression depending on the salmon and sea louse species. Caligus rogercresseyi for example, which affects the salmon industry in Chile, decreases Th1 response, macrophage activation, TLR-mediated response and iron regulation in infected fish. In this study, we explore Atlantic salmon miRNome during infestation by C...
July 12, 2017: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/28689512/circulating-mir-23b-3p-mir-145-5p-and-mir-200b-3p-are-potential-biomarkers-to-monitor-acute-pain-associated-with-laminitis-in-horses
#11
C Lecchi, E Dalla Costa, D Lebelt, V Ferrante, E Canali, F Ceciliani, D Stucke, M Minero
Circulating microRNAs (miRNAs) are emerging as promising biomarkers for several disorders and related pain. In equine practice, acute laminitis is a common disease characterised by intense pain that severely compromises horse welfare. Recently, the Horse Grimace Scale (HGS), a facial expression-based pain coding system, was shown to be a valid welfare indicator to identify pain linked to acute laminitis. The present study aimed to: determine whether miRNAs can be used as biomarkers for acute pain in horses (Equus caballus) affected by laminitis; integrate miRNAs to their target genes and to categorise target genes for biological processes; gather additional evidence on concurrent validity of HGS by investigating how it correlates to miRNAs...
July 10, 2017: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/28683530/quantitative-analysis-of-milk-derived-micrornas-and-microbiota-during-the-manufacturing-and-ripening-of-soft-cheese
#12
Sangnam Oh, Mi Ri Park, Sangdon Ryu, Brighton E Maburutse, Ji-Uk Kim, Younghoon Kim
MicroRNAs (miRNAs) are abundant in bovine milk and milk derived from other livestock, and they have functional roles in infants and in the secretion process of mammary glands. However, few studies have evaluated miRNAs in dairy processes, such as during cheese making and ripening. Thus, we investigated the characteristics of milk-derived miRNAs during the manufacturing and ripening of Camembert cheese as well as the microbiota present using quantitative reverse transcription polymer chain reaction (RT-qPCR) and 16S rRNA pyrosequencing, respectively...
July 7, 2017: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28681200/microrna-expression-signature-of-methamphetamine-use-and-addiction-in-the-rat-nucleus-accumbens
#13
Maw Shin Sim, Tomoko Soga, Vijayapandi Pandy, Yuan Seng Wu, Ishwar S Parhar, Zahurin Mohamed
Methamphetamine (METH) is a highly addictive psycho-stimulant that induces behavioral changes due to high level of METH-induced dopamine in the brain. Nucleus accumbens (NAc) plays an important role in these changes, especially in drug addiction. However, little is known about the underlying molecular mechanisms of METH-induced addiction. The objective of this study was to establish a behavioral model of METH use and addiction using escalating doses of METH over 15 days and to determine the global miRNA expression profiling in NAc of METH-addicted rats...
July 5, 2017: Metabolic Brain Disease
https://www.readbyqxmd.com/read/28675011/-characterization-of-micrornas-profiles-of-induced-pluripotent-stem-cells-reprogrammed-from-human-dental-pulp-stem-cells-and-stem-cells-from-apical-papilla
#14
Tan Xiaobing, Dai Qingyuan
OBJECTIVE: To compare characterization of microRNAs (miRNAs) expression profiles of induced pluripotent stem cells (iPSCs) reprogrammed from human dental pulp stem cells (DPSCs) and stem cells from apical papilla (SCAP) and screen-specific microRNA. METHODS: Human DPSCs and SCAP were reprogrammed into iPSCs using a Sendai virus vector. Total RNA of human DPSCs-iPSCs and SCAP-iPSCs were extracted. miRNAs were labeled and hybridized. Slides were scanned, and images were imported into GenePix Pro 6...
June 1, 2017: Hua Xi Kou Qiang Yi Xue za Zhi, Huaxi Kouqiang Yixue Zazhi, West China Journal of Stomatology
https://www.readbyqxmd.com/read/28658612/senescence-associated-micrornas-target-cell-cycle-regulatory-genes-in-normal-human-lung-fibroblasts
#15
Georgios S Markopoulos, Eugenia Roupakia, Maria Tokamani, George Vartholomatos, Theodore Tzavaras, Maria Hatziapostolou, Frank O Fackelmayer, Raphael Sandaltzopoulos, Christos Polytarchou, Evangelos Kolettas
Senescence recapitulates the ageing process at the cell level. A senescent cell stops dividing and exits the cell cycle. MicroRNAs (miRNAs) acting as master regulators of transcription, have been implicated in senescence. In the current study we investigated and compared the expression of miRNAs in young versus senescent human fibroblasts (HDFs), and analysed the role of mRNAs expressed in replicative senescent HFL-1 HDFs. Cell cycle analysis confirmed that HDFs accumulated in G1/S cell cycle phase. Nanostring analysis of isolated miRNAs from young and senescent HFL-1 showed that a distinct set of 15 miRNAs were significantly up-regulated in senescent cells including hsa-let-7d-5p, hsa-let-7e-5p, hsa-miR-23a-3p, hsa-miR-34a-5p, hsa-miR-122-5p, hsa-miR-125a-3p, hsa-miR-125a-5p, hsa-miR-125b-5p, hsa-miR-181a-5p, hsa-miR-221-3p, hsa-miR-222-3p, hsa-miR-503-5p, hsa-miR-574-3p, hsa-miR-574-5p and hsa-miR-4454...
June 27, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28653606/mir-181a-5p-promotes-proliferation-and-invasion-and-inhibits-apoptosis-of-cervical-cancer-cells-via-regulating-inositol-polyphosphate-5-phosphatase-a-inpp5a
#16
Meng Yang, Xu Zhai, Tingting Ge, Chang Yang, Ge Lou
Expression of miR-181a-5p associates with the proliferation and progression of cancer cells via its targets. This studywas designed to investigate the effect of miR-181a-5p and its target inositol polyphosphate-5-phosphatase A (INPP5A) on progression of cervical cancers. Upregulation of miR-181a-5p was revealed in cervical cancer cell lines HeLa and SiHa in comparison with End1/E6E7 (p < 0.001). The inhibition and upregulation of miR-181a-5p in cervical cancer cell lines significantly reduced or increased cell proliferation and invasion capacity, accompanied with enhanced or reduced apoptosis (p < 0...
June 23, 2017: Oncology Research
https://www.readbyqxmd.com/read/28597963/mir-181a-and-mir-150-regulate-dendritic-cell-immune-inflammatory-responses-and-cardiomyocyte-apoptosis-via-targeting-jak1-stat1-c-fos-pathway
#17
Jianbing Zhu, Kang Yao, Junjie Guo, Hongtao Shi, Leilei Ma, Qian Wang, Haibo Liu, Wei Gao, Aijun Sun, Yunzeng Zou, Junbo Ge
The immune inflammatory response plays a crucial role in many cardiac pathophysiological processes, including ischaemic cardiac injury and the post-infarction repair process. MicroRNAs (miRNAs) regulate the development and function of dendritic cells (DCs), which are key players in the initiation and regulation of immune responses; however, the underlying regulatory mechanisms remain unclear. Here, we used the supernatants of necrotic primary cardiomyocytes (Necrotic-S) to mimic the myocardial infarction (MI) microenvironment to investigate the role of miRNAs in the regulation of DC-mediated inflammatory responses...
June 9, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28590924/analysis-of-mirna-expression-profile-induced-by-short-term-starvation-in-breast-cancer-cells-treated-with-doxorubicin
#18
Sergio Rizzo, Antonina Cangemi, Antonio Galvano, Daniele Fanale, Silvio Buscemi, Marcello Ciaccio, Antonio Russo, Sergio Castorina, Viviana Bazan
Recent studies showed that dietary approaches restricting food intake can be helpful to hinder tumor progression. To date, the molecular mechanisms are unclear and a key role seems to be exerted by nutrient-related signaling pathways. Since several evidences showed that non-coding small RNAs, including microRNAs, are correlated to cancer progression and antiblastic treatment response, our work aims to study their involvement in a triple negative breast cancer (TNBC) cell line treated with doxorubicin under Short Term Starvation (STS) condition...
May 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/28543721/long-non-coding-rna-malat1-regulates-zeb1-expression-by-sponging-mir-143-3p-and-promotes-hepatocellular-carcinoma-progression
#19
Lisha Chen, Hongbing Yao, Kai Wang, Xiangfeng Liu
BACKGROUND: Hepatocellular carcinoma (HCC) is one of the most common malignancies. Long non-coding RNAs (lncRNAs) are involved in HCC. This study aimed to explore the effects of lncRNA MALAT1 on HCC development. METHODS: MALAT1, ZEB1 and miR-143-3p in HCC tissues was detected by qRT-PCR. Effect of MALAT1 on the proliferation and metastasis of HCC cells was estimated by cell-counting, wound-healing and transwell assays. Luciferase reporter assays were used to explore miR-143-3p's target, ZEB1...
May 23, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28535543/microrna-181a-5p-impedes-il-17-induced-nonsmall-cell-lung-cancer-proliferation-and-migration-through-targeting-vcam-1
#20
Yang Cao, Dan Zhao, Ping Li, Lanrong Wang, Bingli Qiao, Xiaoyan Qin, Lei Li, Yang Wang
AIM: The contribution of the inflammatory mediator interleukin-17 (IL-17) in nonsmall cell lung cancer (NSCLC) malignancy has been reported in the literature. MicroRNA-181a-5p (miR-181a-5p) acts as a tumor suppressor which can regulate target gene at the posttranscriptional level. Our study aimed to investigate the interaction between IL-17 and miR-181a-5p in NSCLC. METHODS: 35 patients with NSCLC and 24 COPD controls were selected and examined in our study. In vitro, H226 and H460 cell lines were exposed to different doses (20, 40, 60, and 80 ng/mL) of IL-17 to examine the effect of IL-17 on miR-181a-5p and vascular cell adhesion molecule 1 (VCAM-1) expression...
2017: Cellular Physiology and Biochemistry
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