Khaled AbouAitah, Ahmed M Abdelaziz, Imane M Higazy, Anna Swiderska-Sroda, Abeer M E Hassan, Olfat G Shaker, Urszula Szałaj, Leszek Stobinski, Artur Malolepszy, Witold Lojkowski
It was investigated whether loading multi-wall carbon nanotubes (CNTs) with two natural anticancer agents: ferulic acid (FUA) and diosgenin (DGN), may enhance the anticancer effect of these drugs. The CNTs were functionalized with carboxylic acid (CNTCOOH) or amine (CNTNH2 ), loaded with the above pro-drugs, as well as both combined and coated with chitosan or chitosan-stearic acid. Following physicochemical characterization, the drug-loading properties and kinetics of the drug's release were investigated. Their effects on normal human skin fibroblasts and MCF-7 breast carcinoma cells, HepG2 hepatocellular carcinoma cells, and A549 non-small-cell lung cancer cells were evaluated in vitro...
January 22, 2024: ACS Applied Bio Materials