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https://www.readbyqxmd.com/read/30321637/nucleotide-binding-oligomerization-domain-nod-plays-an-important-role-in-neonatal-infection
#1
Yang Chen, Sheng-Lin Yu, Yi-Ping Li, Ming-Ming Zhang
OBJECTIVE: To explore the expression and function of nucleotide-binding oligomerization domain (NOD) proteins NOD1 and NOD2 and provide guidance for prophylaxis and treatment of neonatal infection. METHODS: Peripheral blood samples were collected from preterm infants, term infants and, healthy adult volunteers. A portion of collected blood was used to examine the expression of NOD1 and NOD2 by real-time PCR. The remaining blood was stimulated in vitro with NOD2 agonist L-Ala-D-Glu-meso (Tri-DAP) or NOD1 agonist muramyl dipeptide (MurNAc-L-Ala-D-isoGln; MDP) for 4 h...
October 12, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/30321291/preterm-birth-changes-networks-of-newborn-cortical-activity
#2
Anton Tokariev, Susanna Stjerna, Aulikki Lano, Marjo Metsäranta, J Matias Palva, Sampsa Vanhatalo
Preterm birth is the greatest risk factor for lifelong neurocognitive deficits, globally. The effect of prematurity on early cortical network function has, however, remained poorly understood. Here, we developed a novel methodology that allows reliable assessment of functional connectivity in neonatal brain activity at millisecond and multisecond scales in terms of cortical phase and amplitude correlations, respectively. We measured scalp electroencephalography at term-equivalent age in infants exposed to very early prematurity as well as in healthy controls...
February 23, 2018: Cerebral Cortex
https://www.readbyqxmd.com/read/30315272/brain-imaging-in-preterm-infants-32-weeks-gestation-a-clinical-review-and-algorithm-for-the-use-of-cranial-ultrasound-and-qualitative-brain-mri
#3
REVIEW
John Ibrahim, Imran Mir, Lina Chalak
The aim is to review the evidence about the utility of term-equivalent age (TEA) magnetic resonance imaging (MRI) in predicting neurodevelopmental outcomes for preterm neonates. Preterm birth accounts for ~12% of all deliveries in the United States and is the leading cause of neurologic disabilities in children. From the neonatologist perspective, it is critically important to identify preterm infants at risk of subsequent neurodevelopmental disability who may benefit from early intervention services. However "the choose wisely campaign" also emphasizes the need to have ongoing cost/benefit discussions regarding care of preterm newborns to avoid waste that comes from subjecting infants to procedures that do not help...
October 12, 2018: Pediatric Research
https://www.readbyqxmd.com/read/30297293/birth-hospitalization-costs-and-days-of-care-for-mothers-and-neonates-in-california-2009-2011
#4
Ciaran S Phibbs, Susan K Schmitt, Matthew Cooper, Jeffrey B Gould, Henry C Lee, Jochen Profit, Scott A Lorch
OBJECTIVE: To provide population-based estimates of the hospital-related costs of maternal and newborn care, and how these vary by gestational age and birth weight. STUDY DESIGN: We conducted a retrospective analysis of 2009-2011 California in-hospital deliveries at nonfederal hospitals with the infant and maternal discharge data successfully (96%) linked to birth certificates. Cost-to-charge ratios were used to estimate costs from charges. Physician hospital payments were estimated by mean diagnosis related group-specific reimbursement and costs were adjusted for inflation to December 2017 values...
October 5, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/30290021/evidence-based-clinical-guidelines-on-analgesia-and-sedation-in-newborn-infants-undergoing-assisted-ventilation-and-endotracheal-intubation
#5
REVIEW
Gina Ancora, Paola Lago, Elisabetta Garetti, Daniele Merazzi, Patrizia Savant Levet, Carlo Valerio Bellieni, Luisa Pieragostini, Anna Pirelli
AIM: This review informed pain control guidelines for clinicians performing mechanical ventilation, nasal continuous positive airway pressure and endotracheal intubation on term and preterm newborn infants. METHODS: We reviewed literature published between 1986 and June 2017 on analgesia and sedation during assisted ventilation and before endotracheal intubation in newborn infants admitted to neonatal intensive care units. The subsequent guidelines were developed using the Grading of Recommendations Assessment, Development and Evaluation approach...
October 5, 2018: Acta Paediatrica
https://www.readbyqxmd.com/read/30283046/impaired-platelet-activity-and-hypercoagulation-in-healthy-term-and-moderately-preterm-newborns-during-the-early-neonatal-period
#6
Ekaterina M Koltsova, Ekaterina N Balashova, Anastasiya A Ignatova, Alexander V Poletaev, Dmitry M Polokhov, Anna D Kuprash, Oleg V Ionov, Anna R Kirtbaya, Anna A Lenyushkina, Leyla A Timofeeva, Victor V Zubkov, Dmitry N Degtyarev, Gennady T Sukhikh, Fazoil I Ataullakhanov, Mikhail A Panteleev, Anna N Balandina
BACKGROUND: Preterm newborns are at thrombohemorrhagic risk during the early neonatal period. Taking into account the lack of informative tools for the laboratory diagnosis of hemostasis disorders in newborns, our goal was to determine the baseline values of thrombodynamics and platelet functional activity in healthy term and moderately preterm newborns during the early neonatal period future potential clinical use of these tests. METHODS: Coagulation was assessed using an integral assay of thrombodynamics and standard coagulation assays, and platelet functional activity was estimated by flow cytometry...
September 18, 2018: Pediatric Research
https://www.readbyqxmd.com/read/30276964/microvascular-circulatory-dysregulation-driven-in-part-by-cystathionine-gamma-lyase-a-new-paradigm-for-cardiovascular-compromise-in-the-preterm-newborn
#7
Rebecca M Dyson, Hannah K Palliser, Nicole Wilding, Megan A Kelly, Grazyna Chwatko, Rafal Glowacki, Mary J Berry, Xin Ni, Ian M R Wright
OBJECTIVE: Hydrogen sulphide (H2 S) may explain the dysregulation of microvascular tone associated with poor outcome following preterm birth. In adult vasculature, H2 S is predominantly produced by cystathionine-γ-lyase (CSE). We hypothesised that vascular CSE activity contributes to microvascular tone regulation during circulatory transition. METHOD: Preterm (GA62) and full-term (GA69) guinea pig fetuses and neonates were studied. Microvascular blood flow was assessed by laser Doppler flowmetry...
October 1, 2018: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/30264855/association-of-spontaneous-labor-onset-with-neonatal-outcomes-in-pregnancies-with-fetal-gastroschisis-a-retrospective-cohort-analysis
#8
Gilmar de Souza Osmundo Junior, Samirah Hosney Mahmoud Mohamed, Estela Naomi Nishie, Ana Cristina Aoun Tannuri, Maria Augusta Bento Cicaroni Gibelli, Rossana Pulcineli Vieira Francisco, Maria de Lourdes Brizot
INTRODUCTION: The present study aims to investigate the association of spontaneous labor onset with neonatal outcomes in pregnancies with fetal gastroschisis. The secondary goal was to evaluate the association between ultrasound markers and labor onset in pregnancies with fetal gastroschisis. MATERIAL AND METHODS: A retrospective analysis was performed for 207 pregnancies with fetal gastroschisis followed between 2005 and 2017. Patients were followed according to a strict protocol involving ultrasound scans and routine evaluations of fetal biophysical profile parameters and intra- and extra-abdominal bowel diameters...
September 28, 2018: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/30264852/ibuprofen-for-the-treatment-of-patent-ductus-arteriosus-in-preterm-or-low-birth-weight-or-both-infants
#9
REVIEW
Arne Ohlsson, Rajneesh Walia, Sachin S Shah
BACKGROUND: Indomethacin is used as standard therapy to close a patent ductus arteriosus (PDA) but is associated with reduced blood flow to several organs. Ibuprofen, another cyclo-oxygenase inhibitor, may be as effective as indomethacin with fewer adverse effects. OBJECTIVES: To determine the effectiveness and safety of ibuprofen compared with indomethacin, other cyclo-oxygenase inhibitor(s), placebo, or no intervention for closing a patent ductus arteriosus in preterm, low-birth-weight, or preterm and low-birth-weight infants...
September 28, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/30248203/analgesics-and-sedatives-in-critically-ill-newborns-and-infants-the-impact-on-long-term-neurodevelopment
#10
R M Schiller, K Allegaert, Maayke Hunfeld, G E van den Bosch, John van den Anker, D Tibboel
Inadequate pain and/or stress management in preterm- and term-born infants has been associated with increased morbidity and even mortality. However, exposure to analgosedatives during early infancy may also be one of the risk factors for subsequent neurodevelopmental impairment, at least in animal studies. Because infants admitted to neonatal or pediatric intensive care units may receive high amounts of these drugs for prolonged periods of time and the majority of these infants nowadays survive to discharge, this is of major concern...
October 2018: Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/30244363/vaginal-ureaplasma-species-increase-chorioamnionitis-in-very-preterm-infants-with-preterm-premature-rupture-of-the-membranes-at-28-weeks-of-gestation
#11
Yu Suzuki, Kenji Horie, Yukari Yada, Yumi Kono, Chikako Hirashima, Rie Usui, Shigeki Matsubara, Akihide Ohkuchi
Our aim was to investigate the association between vaginal Ureaplasma species (spp.) and the subsequent occurrence of chorioamnionitis (CAM), perinatal death, neonatal morbidity, and long-term neurodevelopmental impairments (NDIs) at 3 years of age. We analyzed 55 pregnant women with singleton pregnancy who had preterm premature rupture of the membranes (pPROM) at < 28+0  weeks of gestation, and delivered between 22+0 and 31+6 weeks at our tertiary hospital in 2007-2016. NDIs were defined as either cerebral palsy or developmental delay evaluated at 1...
September 22, 2018: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/30242935/evaluation-of-neurological-behaviour-in-late-preterm-newborn-infants-using-the-hammersmith-neonatal-neurological-examination
#12
En Yi Joanne Chin, Vijay R Baral, Imelda L Ereno, John C Allen, Kelly Low, Cheo Lian Yeo
AIM: We hypothesise that clinically well late-preterm infants (LPI) (34+0 -36+6 weeks) are neurologically more immature than their term counterparts, and this immaturity persists even when these infants reach term-corrected age (TCA). The primary aim of our study was to characterise and contrast the neurodevelopmental profile of well LPI with full-term infants (FTI) (39+0 -41+6 weeks) using the Hammersmith Neonatal Neurological Examination (HNNE). Our secondary aim was to obtain local reference ranges for the 34 items in the HNNE in an Asian-dominant population...
September 21, 2018: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/30192257/does-gestational-age-affect-ultrasonographic-findings-of-the-hip-in-preterm-newborns-a-sonographic-study-of-the-early-neonatal-period
#13
Altuğ Duramaz, Burcu B Duramaz, Mustafa G Bilgili
There are only a few studies in the literature investigating the effects of gestational age on developmental dysplasia of the hip. The aim of this study was to investigate the effects of gestational age on hip ultrasound findings in the early neonatal period in preterm newborns born between 30th and 36th weeks of gestational age. Between January 2008 and December 2013, a total of 788 hips of 394 premature newborns with a gestational age of up to 36th weeks who underwent hip ultrasonography in the first week of their life were retrospectively examined...
September 5, 2018: Journal of Pediatric Orthopedics. Part B
https://www.readbyqxmd.com/read/30188500/early-human-brain-development-insights-into-macroscale-connectome-wiring
#14
Kristin Keunen, Hannelore K van der Burgh, Marcel A de Reus, Pim Moeskops, Ruben Schmidt, Lisanne J Stolwijk, Siemon C de Lange, Ivana Išgum, Linda S de Vries, Manon J Benders, Martijn P van den Heuvel
BACKGROUND: Early brain development is closely dictated by distinct neurobiological principles. Here, we aimed to map early trajectories of structural brain wiring in the neonatal brain. METHODS: We investigated structural connectome development in 44 newborns, including 23 preterm infants and 21 full-term neonates scanned between 29 and 45 postmenstrual weeks. Diffusion-weighted imaging data were combined with cortical segmentations derived from T2 data to construct neonatal connectome maps...
August 15, 2018: Pediatric Research
https://www.readbyqxmd.com/read/30172626/transcutaneous-bilirubin-nomogram-for-taiwanese-newborns-a-single-center-study
#15
Tung-Hua Chen, Yung-Chieh Lin, Yuh-Jyh Lin, Chyi-Her Lin
BACKGROUND: Hour-specific bilirubin nomogram has been recommended to predict postdischarge hyperbilirubinemia in newborns. However, it may not be applicable in Taiwan due to ethnic differences. The aim of this study was to construct a 12-h specific transcutaneous bilirubin (TCB) nomogram in newborns for clinical reference. METHODS: We prospectively enrolled full term or late preterm neonates born in a tertiary care hospital between October 2013 and July 2014. The exclusion criteria included chromosome anomaly, glucose-6-phosphate dehydrogenase deficiency, and receiving phototherapy within 60 h after birth...
August 2, 2018: Pediatrics and Neonatology
https://www.readbyqxmd.com/read/30151665/spiritual-care-in-neonatology-analysis-of-emergency-baptisms-in-an-irish-neonatal-unit-over-15-years
#16
Fionnuala M Caulfield, Omolola A Ihidero, Marie Carroll, Margo Dunworth, Marie Hunt, Desmond McAuliffe, Roy K Philip
BACKGROUND: Emergency baptism remains an important emotional and spiritual element for many parents of critically ill infants in the neonatal unit. There is no published data available as to which neonates are baptised and their outcomes. OBJECTIVES: To evaluate trends, outcomes and characteristics of newborn infants baptised over a 15-year period in an Irish maternity hospital. METHODS: Retrospective study of infants baptised in University Maternity Hospital Limerick (UMHL) over a 15-year period...
August 27, 2018: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/30149811/maternal-views-on-facilitators-of-and-barriers-to-breastfeeding-preterm-infants
#17
Maria Lorella Gianni, Elena Nicoletta Bezze, Patrizio Sannino, Michela Baro, Paola Roggero, Salvatore Muscolo, Laura Plevani, Fabio Mosca
BACKGROUND: The supply of breast milk to preterm infants tends to occur at a lower rate than that recorded among term infants. We aimed to investigate the facilitators of and barriers to breastfeeding during hospital stay according to the experiences of mothers that gave birth to premature infants requiring admission to neonatal intensive care unit. METHODS: A cross-sectional questionnaire survey was conducted. Mothers who had delivered a newborn with a gestational age ≤33 weeks requiring intensive care, entered the study...
August 27, 2018: BMC Pediatrics
https://www.readbyqxmd.com/read/30145107/characterization-of-group-b-streptococcus-colonization-in-full-term-and-lete-preterm-neonates-in-taiwan
#18
Jen-Fu Hsu, Chyi-Liang Chen, Chien-Chung Lee, Reyin Lien, Shih-Ming Chu, Ren-Huei Fu, Ming-Chou Chiang, Chang-Yo Yang, Mei-Yin Lai, I-Hsyuan Wu, Yu-Shan Yen, Cheng-Hsun Chiu
BACKGROUND: Group B streptococcus (GBS) infections can be life-threatening in newborns. This study aimed to analyze GBS carriage status and genotypic diversity in healthy neonates after implementation of intrapartum antibiotic prophylaxis (IAP) in Taiwan. METHODS: Newborns carrying GBS were identified from a screen of 500 newborns and followed up until their cultures turned negative. Their mothers' GBS screening data were reviewed. Molecular methods, including capsular serotyping, multilocus sequence typing and pulsed-field gel electrophoresis (PFGE), were used to analyze GBS isolates...
August 2, 2018: Pediatrics and Neonatology
https://www.readbyqxmd.com/read/30138603/systematic-review-of-quality-improvement-initiatives-related-to-cue-based-feeding-in-preterm-infants
#19
REVIEW
Tena J Fry, Stephanie Marfurt, Sharon Wengier
OBJECTIVE: To examine and synthesize the outcomes of quality improvement (QI) initiatives related to cue-based feeding of preterm infants to facilitate implementation of findings to improve nursing practice. DATA SOURCES: Cumulative Index of Nursing and Allied Health Literature (CINAHL) Complete and PubMed were searched for full-text articles published from 2000 through 2017 included under the medical subject heading quality improvement and whose titles included any form of the term feeding combined with any of the following: bottle, breast, cue-based, demand, infant, neonate, newborn, oral, or responsive...
October 2018: Nursing for Women's Health
https://www.readbyqxmd.com/read/30132843/incidence-of-neonatal-seizures-perinatal-risk-factors-for-epilepsy-and-mortality-after-neonatal-seizures-in-the-province-of-parma-italy
#20
Francesco Pisani, Carlotta Facini, Elisa Bianchi, Giorgia Giussani, Benedetta Piccolo, Ettore Beghi
OBJECTIVE: Information about the incidence of neonatal seizures (NS) is scarce. Previous studies relied primarily on a clinical diagnosis of seizures. This population-based, retrospective study evaluated the incidence of electroencephalography (EEG)-confirmed seizures in neonates born in the province of Parma and the perinatal risk factors for mortality and epilepsy. METHODS: All neonates with suspected seizures or with medical conditions at high risk for seizures from the study area were recorded in the neonatal intensive care unit (NICU) of the Parma University Hospital...
September 2018: Epilepsia
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