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Neonates,newborn,term ,preterm

Lisandra Stein Bernardes, Juliana Fontan Ottolia, Marina Cecchini, Antônio Gomes de Amorim Filho, Manoel Jacobsen Teixeira, Rossana Pulcineli Vieira Francisco, Daniel Ciampi de Andrade
Introduction: Although pain facial assessment is routinely performed in term and preterm newborns by the use of facial expression-based tools such as the Neonatal Facial Coding System, the assessment of pain during the intrauterine life has not been extensively explored. Objective: Describe for the first time, an experimental model to assess and quantify responses due to acute pain in fetuses undergoing anaesthesia for intrauterine surgery recorded by high-resolution 4D ultrasound machines...
September 2018: Pain Reports (Baltimore, Md.)
Jun Shiraishi, Satoshi Kusuda, Kazutoshi Cho, Atsushi Nakao, Takehiko Hiroma, Hiroshi Sugiura, Satoshi Suzuki, Makoto Oshiro, Seiji Yoshimoto, Shinichi Watabe
BACKGROUND: In perinatal medicine, inhaled nitric oxide (iNO) has been an important tool for the treatment of full-term and late-preterm infants with persistent pulmonary hypertension of the newborn (PPHN) and hypoxemic respiratory failure (HRF). However, its use in more premature infants is controversial. To evaluate the current clinical practices regarding use of acute inhaled nitric oxide (iNO) therapy in extremely preterm infants, a nationwide survey was conducted in Japan. METHODS: A questionnaire survey was conducted from May to September, 2015...
December 6, 2018: Pediatrics International: Official Journal of the Japan Pediatric Society
Noémia Rosado Silva, Joana Oliveira, Alberto Berenguer, André M Graça, Margarida Abrantes, Carlos Moniz
INTRODUCTION: Prematurity and low birth weight have been associated with increased neonatal morbidity and mortality. This study aimed to evaluate possible risk factors for prematurity associated with fetal growth restriction and being small for gestational age and to determine the incidence of morbidity in these two groups of infants. MATERIAL AND METHODS: Retrospective case-control study of newborns with gestational age of less than 32 weeks, with obstetric diagnosis of fetal growth restriction and with the clinical diagnosis of small for gestational age, admitted to the Neonatal Intensive Care Unit of a tertiary hospital for a period of six years...
November 30, 2018: Acta Médica Portuguesa
Unzila Ali Nayeri, Catalin S Buhimschi, Guomao Zhao, Irina A Buhimschi, Vineet Bhandari
We aimed to test the hypothesis that determinants of the perinatal clinical exposome related to the underlying etiology of premature birth (PTB) impact differently on select neonatal outcomes. We conducted a prospective longitudinal study of 377 singleton preterm neonates [gestational age (GA) at birth: 23-34 weeks] separated into three distinct contemporaneous newborn cohorts: i) spontaneous PTB in the setting of intra-amniotic infection/inflammation (yes-IAI, n = 116); ii) spontaneous PTB in the absence of IAI (no-IAI, n = 130), and iii) iatrogenic PTB for preeclampsia (iPTB-PE, n = 131)...
2018: PloS One
Helen E Groves, Hong Guo-Parke, Lindsay Broadbent, Michael D Shields, Ultan F Power
BACKGROUND: Innate immune responses of airway epithelium are important defences against respiratory pathogens and allergens. Newborn infants are at greater risk of severe respiratory infections compared to older infants, while premature infants are at greater risk than full term infants. However, very little is known regarding human neonatal airway epithelium immune responses and whether age-related morphological and/or innate immune changes contribute to the development of airway disease...
2018: PloS One
Megan O'reilly, Georg M Schmölzer
An estimated 0.1% of term infants and up to 15% of preterm infants (2-3 million worldwide) need extensive resuscitation, defined as chest compression and 100% oxygen with or without epinephrine in the delivery room. Despite these interventions, infants receiving extensive resuscitation in the DR have a high incidence of mortality and neurologic morbidity. Successful resuscitation from neonatal cardiac arrest requires the delivery of high-quality chest compression using the most effective vasopressor with the optimal dose, timing, and route of administration during CPR...
December 3, 2018: Minerva Pediatrica
Bo-Hao Tang, Yue-E Wu, Chen Kou, Yu-Jie Qi, Hui Qi, Hai-Yan Xu, Stephanie Leroux, Xin Huang, Yue Zhou, Yi Zheng, Evelyne Jacqz-Aigrain, A-Dong Shen, Wei Zhao
Backgrounds: Amoxicillin is widely used to treat bacterial infections in neonates. However, considerable inter-center variability in dosage regimens of antibiotic exist in clinical practice. Pharmacokinetics of amoxicillin has been described in only a few preterm neonates. Thus, we aimed to evaluate population pharmacokinetics of amoxicillin through a large samples covered entire age range of neonates and young infants, and establish evidence-based dosage regimens based on developmental pharmacokinetics-pharmacodynamics...
December 3, 2018: Antimicrobial Agents and Chemotherapy
Ijeoma Esiaba, Danilyn M Angeles, Terry-Ann M Milford, Lorena M Salto, Kimberly J Payne, Melissa Y Kidder, Danilo S Boskovic
OBJECTIVE: To quantify platelet-neutrophil interaction by flow cytometry, in newborn cord blood, as a function of gestational age. RATIONALE: Little is known about platelet function markers in the newborn, and developmental variations in these markers are not well described. METHODS: Cord blood samples were obtained from 64 newborns between 23 and 40 weeks' gestation. The neonates were grouped into three categories: preterm (< 34 weeks' gestation, n = 21), late preterm (34 to < 37 weeks' gestation, n = 22), and term (≥37 weeks' gestation, n = 21)...
November 27, 2018: Neonatology
Nancy Medley, Joshua P Vogel, Angharad Care, Zarko Alfirevic
BACKGROUND: Preterm birth (PTB) is a major factor contributing to global rates of neonatal death and to longer-term health problems for surviving infants. Both the World Health Organization and the United Nations consider prevention of PTB as central to improving health care for pregnant women and newborn babies. Current preventative clinical strategies show varied efficacy in different populations of pregnant women, frustrating women and health providers alike, while researchers call for better understanding of the underlying mechanisms that lead to PTB...
November 14, 2018: Cochrane Database of Systematic Reviews
Nicole Thiele, Johanna M Walz, Verena Lindacher, Silke Mader, Gorm Greisen
The European Foundation for the Care of Newborn Infants (EFCNI) is the first pan-European organisation and network to represent the interests of preterm and newborn infants and their families. The Foundation brings together parents, healthcare experts from different disciplines and scientists with the common goal of improving the long-term health of preterm and newborn infants. It does this by ensuring that infants receive the best possible prevention, treatment, care and support, based on the best available evidence, which has ideally been proven in high-quality randomised, controlled clinical trials (1)...
November 26, 2018: Acta Paediatrica
Flaminia Bardanzellu, Vassilios Fanos, Alessandra Reali
Breast Milk (BM) is the best source of nutrition for newborns, especially if premature. In fact, its beneficial impact on short- and long-term neonatal outcome has was deeply described. Unfortunately, BM could not be always so safe, especially due to the possible presence of maternal viruses that can shed and transferred to the breastfed neonate. Among these, Cytomegalovirus (CMV) can potentially lead to a serious and acute illness, mostly in case of low gestational age. Some studies also report the association of CMV-acquired infection to an increased risk of structural and functional brain modifications and neurological impairment...
November 25, 2018: Current Pediatric Reviews
Marta Campanile, Pietro D'Alessandro, Luigi Della Corte, Gabriele Saccone, Salvatore Tagliaferri, Bruno Arduino, Giuseppina Esposito, Francesca Giovanna Esposito, Antonio Raffone, Maria Gabriella Signorini, Giovanni Magenes, Mariarosaria Di Tommaso, Serena Xodo, Fulvio Zullo, Vincenzo Berghella
OBJECTIVE: To evaluate whether intrapartum cardiotocography with computer analysis decreases the incidence of newborn metabolic acidosis or obstetric intervention when compared with visual analysis through a systematic review with meta-analysis of randomized controlled trials. METHODS: The research was conducted using Medline, Embase, Web of Science, Scopus,, Ovid and Cochrane Library as electronic databases from the inception of each database to May 2018...
November 18, 2018: Journal of Maternal-fetal & Neonatal Medicine
Fatma Zohra Chioukh, Karim Ben Ameur, Nédia Kasdallah, Sonia Blibech, Emira Ben Hamida, Imen Ayadi, Héchmi Ben Hamouda, Habib Soua, Manel Charfi, Nédia Hamida, Kamel Monastiri, Mohamed Douagi, Zahra Marrakchi, Abdellatif Gargouri
BACKGROUND: Extremely preterm infants are newborns born before 28 weeks of gestation. Survival of these immature newborns depends on resuscitation and the quality of care during hospitalization. OBJECTIVE: To determine survival and neurologic outcomes at2 years after extremely preterm birth. METHODS: It is a retrospective multicentric study in 5 neonatal intensive care units (NICU) in 2012-2013.All live births less than 28 weeks gestation were included...
August 2018: La Tunisie Médicale
Musa Silahli, Enes Duman, Zeynel Gokmen, Erzat Toprak, Mahmut Gokdemir, Ayse Ecevit
OBJECTIVE: To compare the effect of umbilical cord milking and early cord clamping on thymic size, and neonatal mortality and morbidity in preterm infants. METHODS: This single-center, prospective, double-blind, randomised controlled study was conducted at Baskent University, Konya Education and Research Centre, Konya, Turkey, between October 2015 and April 2016. Pregnant women who delivered before 32 weeks of gestation were randomised to receive umbilical cord milking (group 1) or early cord clamping (group 2)...
November 2018: JPMA. the Journal of the Pakistan Medical Association
Carlotta Spagnoli, Raffaele Falsaperla, Michela Deolmi, Giovanni Corsello, Francesco Pisani
Neonatal seizures are the most common neurological event in newborns, showing higher prevalence in preterm than in full-term infants. In the majority of cases they represent acute symptomatic phenomena, the main etiologies being intraventricular haemorrhage, hypoxic-ischemic encephalopathy, central nervous system infections and transient metabolic derangements.Current definition of neonatal seizures requires detection of paroxysmal EEG-changes, and in preterm newborns the incidence of electrographic-only seizures seems to be particularly high, further stressing the crucial role of electroencephalogram monitoring in this population...
November 1, 2018: Italian Journal of Pediatrics
Asmaa M Zahran, Khaled Saad, Yasser F Abdel-Raheem, Khalid I Elsayh, Amira A El-Houfey, Mohamed Diab Aboul-Khair, Mohamd A Alblihed
Our study aimed to study regulatory T cells (Tregs) and their expression of CD45RA, HLA-DR, and CD39 in preterm and full-term infants. In an observational study, we used a three-color flow cytometry for determination of Tregs and their expression of CD45RA, HLA-DR, and CD39 in preterm and full-term infants. The percentages of CD4+ CD25+high Foxp3+ , CD39+ Tregs, HLA-DR+ Tregs and the expression of Foxp3+ in CD4+ CD25+high Foxp3 Tregs cells were significantly lower in neonates when compared to healthy adult controls...
October 29, 2018: Archivum Immunologiae et Therapiae Experimentalis
Joshua I Rosenbloom, Adam K Lewkowitz, Kristina E Sondgeroth, Jessica L Hudson, George A Macones, Alison G Cahill, Methodius G Tuuli, Su-Hsin Chang
OBJECTIVE: To evaluate whether administration of antenatal late-preterm betamethasone is cost-effective in the immediate neonatal period. STUDY DESIGN: Cost-effectiveness analysis of late-preterm betamethasone administration with a time horizon of 7.5 days was conducted using a health-system perspective. Data for neonatal outcomes, including respiratory distress syndrome (RDS), transient tachypnea of the newborn (TTN), and hypoglycemia, were from the Antenatal Betamethasone for Women at Risk for Late-Preterm Delivery trial...
November 15, 2018: Journal of Maternal-fetal & Neonatal Medicine
Parisa Parsa, Simin Karimi, Behnaz Basiri, Godratalah Roshanaei
Introduction: Breast-feeding and being with mother have positive effects on the preterm infant's health status. Therefore, this study was conducted to evaluate the effect of Kangaroo Mother Care (KMC) on physiological parameters of premature infants in Fatemiyeh Hospital in Hamadan in 2016. Methods: This was a quasi-experimental study. One hundred newborns who were admitted to in neonatal intensive care unit of Fatemiyeh Hospital in Hamadan city, Iran were selected by convenience sampling...
2018: Pan African Medical Journal
C Casper, I Sarapuk, H Pavlyshyn
INTRODUCTION: Skin-to-skin contact (SSC) is a cornerstone of neurodevelopment and family-oriented care for preterm infants. The purpose of the present study was to investigate the effectiveness of skin-to-skin contact in preterm babies depending on regularity, duration, and the period of the first contact. MATERIALS AND METHODS: This retrospective study involved 26 premature infants with gestational age 24/0-28/6 weeks who were treated in the neonatal intensive care unit and neonatal department...
November 2018: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
Yang Chen, Sheng-Lin Yu, Yi-Ping Li, Ming-Ming Zhang
OBJECTIVE: To explore the expression and function of nucleotide-binding oligomerization domain (NOD) proteins NOD1 and NOD2 and provide guidance for prophylaxis and treatment of neonatal infection. METHODS: Peripheral blood samples were collected from preterm infants, term infants and, healthy adult volunteers. A portion of collected blood was used to examine the expression of NOD1 and NOD2 by real-time PCR. The remaining blood was stimulated in vitro with NOD2 agonist L-Ala-D-Glu-meso (Tri-DAP) or NOD1 agonist muramyl dipeptide (MurNAc-L-Ala-D-isoGln; MDP) for 4 h...
January 2019: International Journal of Biological Macromolecules
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