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muscle mass and liver cirrhosis

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https://www.readbyqxmd.com/read/30094402/l-carnitine-suppresses-loss-of-skeletal-muscle-mass-in-patients-with-liver-cirrhosis
#1
Masatsugu Ohara, Koji Ogawa, Goki Suda, Megumi Kimura, Osamu Maehara, Tomoe Shimazaki, Kazuharu Suzuki, Akihisa Nakamura, Machiko Umemura, Takaaki Izumi, Naoki Kawagishi, Masato Nakai, Takuya Sho, Mitsuteru Natsuizaka, Kenichi Morikawa, Shunsuke Ohnishi, Naoya Sakamoto
Liver cirrhosis (LC) is a major cause of secondary sarcopenia. Sarcopenia makes the prognosis worse; thus, novel therapeutic options for sarcopenia in patients with LC are urgently required as they are currently limited. In this retrospective study, 158 patients with LC were screened, and 35 of those patients who were treated with L-carnitine for more than 6 months and for whom skeletal muscle mass changes could be evaluated by computer tomography were enrolled. Of the 158 patients, 79 patients who did not receive L-carnitine supplementation served as controls...
August 2018: Hepatology communications
https://www.readbyqxmd.com/read/30040184/relationship-between-total-body-protein-and-cross-sectional-skeletal-muscle-area-in-liver-cirrhosis-is-influenced-by-overhydration
#2
Cameron I Wells, John L McCall, Lindsay D Plank
Sarcopenia as defined by reduced skeletal muscle area (SMA) on cross-sectional abdominal imaging has been proposed as an objective measure of malnutrition, and is associated with both waitlist mortality and post-transplant complications in patients with cirrhosis. SMA, however, has never been validated against the gold-standard measurement of total body protein (TBP) by in vivo neutron activation analysis (IVNAA). Furthermore, overhydration is common in cirrhosis and its effect on muscle area measurement remains unknown...
July 24, 2018: Liver Transplantation
https://www.readbyqxmd.com/read/30018475/liver-transplantation-and-alcoholic-liver-disease-history-controversies-and-considerations
#3
REVIEW
Claudio Augusto Marroni, Alfeu Medeiros Fleck, Sabrina Alves Fernandes, Lucas Homercher Galant, Marcos Mucenic, Mario Henrique de Mattos Meine, Guilherme Mariante-Neto, Ajacio Bandeira de Mello Brandão
Alcohol consumption accounts for 3.8% of annual global mortality worldwide, and the majority of these deaths are due to alcoholic liver disease (ALD), mainly alcoholic cirrhosis. ALD is one of the most common indications for liver transplantation (LT). However, it remains a complicated topic on both medical and ethical grounds, as it is seen by many as a "self-inflicted disease". One of the strongest ethical arguments against LT for ALD is the probability of relapse. However, ALD remains a common indication for LT worldwide...
July 14, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/30007480/prognostic-value-of-energy-expenditure-and-respiratory-quotient-measuring-in-patients-with-liver-cirrhosis
#4
G Belarmino, P Singer, M C Gonzalez, N M Machado, C S Cardinelli, S Barcelos, W Andraus, L A C D'Albuquerque, L Damiani, A C Costa, R M R Pereira, S B Heymsfield, P Sala, R S M Torrinhas, D L Waitzberg
BACKGROUND & AIMS: Resting energy expenditure (REE) and respiratory quotient (RQ) as measured by indirect calorimetry (IC) may correlate with muscle mass and represent prognostic indicators in treating patients with liver cirrhosis. We aimed to assess the correlation of IC-measured REE and RQ with skeletal muscle mass (SM), mortality, and REE values as estimated by Harris-Benedict, European guidelines (EG), and Brazilian guidelines-DITEN (BG) equations in patients with liver cirrhosis...
July 6, 2018: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29996772/taurocholic-acid-is-an-active-promoting-factor-not-just-a-biomarker-of-progression-of-liver-cirrhosis-evidence-from-a-human-metabolomic-study-and-in-vitro-experiments
#5
Zhimin Liu, Zhifeng Zhang, Mei Huang, Xiaoping Sun, Bojia Liu, Qiyang Guo, Qingshan Chang, Zhijun Duan
BACKGROUND: Previous studies have indicated that bile acid is associated with progression of liver cirrhosis. However, the particular role of specific bile acid in the development of liver cirrhosis is not definite. The present study aims to identify the specific bile acid and explore its possible mechanisms in promoting liver cirrhosis. METHODS: Thirty two cirrhotic patients and 27 healthy volunteers were enrolled. Age, gender, Child-Pugh classification and serum of patients and volunteers were collected...
July 11, 2018: BMC Gastroenterology
https://www.readbyqxmd.com/read/29991895/muscle-fat-infiltration-assessed-by-total-psoas-density-on-computed-tomography-predicts-mortality-in-cirrhosis
#6
Maria Kalafateli, Andreas Karatzas, Georgios Tsiaoussis, Efstratios Koutroumpakis, Paraskevi Tselekouni, Nikolaos Koukias, Christos Konstantakis, Stelios Assimakopoulos, Charalambos Gogos, Konstantinos Thomopoulos, Christina Kalogeropoulou, Christos Triantos
Background: Ongoing evidence suggests that sarcopenia adversely affects outcomes in cirrhosis. The aim of this study was to evaluate muscle fat infiltration as a component of sarcopenia and its prognostic value in this setting. Methods: In 98 consecutive patients with cirrhosis, muscle density was measured during a computed tomography scan at the level of the fourth to fifth lumbar (L4) vertebrae. Univariate and multivariate Cox regression analysis was used to determine predictors of survival...
July 2018: Annals of Gastroenterology: Quarterly Publication of the Hellenic Society of Gastroenterology
https://www.readbyqxmd.com/read/29964066/exercise-in-cirrhosis-translating-evidence-and-experience-to-practice
#7
REVIEW
Puneeta Tandon, Kathleen Patricia Ismond, Kenneth Riess, Andres Duarte-Rojo, Bandar Al-Judaibi, Michael Andrew Dunn, Jennifer Holman, Nancy Howes, Mark Joseph Franklin Haykowsky, Deborah Ann Josbeno, Margaret McNeely
Physical inactivity, sarcopenia, and frailty are highly prevalent, independent predictors of morbidity and mortality in patients with cirrhosis. Across a range of chronic diseases, exercise training is a key recommendation supported by guidelines and, in some conditions, even by governmental funding of exercise programs. Consistent with the broader chronic disease literature, the evidence for a benefit of exercise in cirrhosis is promising. Several small trials have reported significant improvements in muscle health (mass, strength, functional capacity), quality of life, fatigue, and reductions in the hepatic venous portal gradient, without adverse events...
June 28, 2018: Journal of Hepatology
https://www.readbyqxmd.com/read/29893704/association-between-low-testosterone-levels-and-sarcopenia-in-cirrhosis-a-cross-sectional-study
#8
Carlos Moctezuma-Velázquez, Gavin Low, Marina Mourtzakis, Mang Ma, Kelly W Burak, Puneeta Tandon, Aldo J Montano-Loza
INTRODUCTION AND AIM: Sarcopenia is an independent predictor of mortality in cirrhosis. Hypogonadism is common in cirrhosis and has been associated with sarcopenia in non-cirrhotic chronic liver disease populations. The aim of this study is to investigate if sarcopenia is associated with low testosterone levels in patients with cirrhosis. MATERIAL AND METHODS: This is a retrospective analysis of prospectively collected data of 211 cirrhotic patients undergoing evaluation for liver transplantation...
July 2018: Annals of Hepatology
https://www.readbyqxmd.com/read/29738109/sarcopenic-obesity-in-cirrhosis-the-confluence-of-2-prognostic-titans
#9
REVIEW
Tannaz Eslamparast, Aldo J Montano-Loza, Maitreyi Raman, Puneeta Tandon
Sarcopenia and obesity are 2 major health conditions with a growing prevalence in cirrhosis. The concordance of these 2 conditions, sarcopenic obesity, is associated with higher rates of mortality and impact on the metabolic profile and physical function than either condition alone. To date, there is little consensus surrounding the diagnostic criteria for sarcopenia, obesity or as a result, sarcopenic obesity in patients with cirrhosis. Cross-sectional imaging, although the most accurate diagnostic technique, has practical limitations for routine use in clinical practice...
May 8, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/29734510/association-between-sarcopenia-and-osteoporosis-in-chronic-liver-disease
#10
Manabu Hayashi, Kazumichi Abe, Masashi Fujita, Ken Okai, Atsushi Takahashi, Hiromasa Ohira
AIM: Sarcopenia and osteoporosis are important complications in chronic liver disease (CLD). The aim of this study was to investigate the relationship between sarcopenia and osteoporosis in patients with CLD. METHODS: We retrospectively investigated the relationship between sarcopenia and osteoporosis in 112 CLD patients (57 men and 55 women), including 40 cirrhotic patients (36%), by measuring the appendicular skeletal muscle mass index (ASMI) using bio-impedance analysis...
May 7, 2018: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/29596718/bioelectrical-impedance-analysis-derived-measurements-in-chronic-hepatitis-c-clinical-relevance-of-fat-free-mass-and-phase-angle-evaluation
#11
Tatiana Bering, Kiara G D Diniz, Marta Paula P Coelho, Ana Carolina M de Souza, Luisa Freitas de Melo, Diego Alves Vieira, Maria Marta S Soares, Adriana M Kakehasi, Maria Isabel T D Correia, Rosângela Teixeira, Dulciene Maria Magalhães Queiroz, Gifone A Rocha, Luciana D Silva
OBJECTIVE: Because cirrhotic patients are at high risk of malnutrition and sarcopenia, we evaluated the prevalence of low fat-free mass index (FFMI) and low phase angle (PhA) among patients with chronic hepatitis C (CHC). METHODS: In total, 135 subjects with CHC (50.4% males; mean age, 52.4 ± 11.8 years; 65.9% noncirrhotic and 34.1% compensated cirrhotic patients) were prospectively included and evaluated by bioelectrical impedance analysis. Subjective global assessment was used to evaluate malnutrition...
April 2018: Nutrition in Clinical Practice
https://www.readbyqxmd.com/read/29514643/unusual-presentation-of-a-hepatocellular-carcinoma-as-a-potential-late-side-effect-of-radiotherapy-in-a-patient-treated-for-wilms-tumor-in-childhood
#12
Deborah Repullo, Marie Diaz, Stéphane Holbrechts, Maria Gomez-Galdón, Dirk Van Gestel, Ali Bohlok, Gabriel Liberale, Vincent Donckier
BACKGROUND: The development of a second primary tumor is a potential late side effect of radiotherapy. Particularly, an increased risk of secondary cancers, mostly of digestive or breast origin, has been observed in patients treated with high-dose radiotherapy for Wilms tumor (WT) in childhood. However, hepatocellular carcinoma (HCC) has been very rarely described as a potentially radiotherapy-induced tumor. We describe the case of a patient with an aggressive HCC 50 years after the treatment of a WT...
March 7, 2018: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29349902/association-between-pre-sarcopenia-sarcopenia-and-bone-mineral-density-in-patients-with-chronic-hepatitis-c
#13
Tatiana Bering, Kiara G D Diniz, Marta Paula P Coelho, Diego A Vieira, Maria Marta S Soares, Adriana M Kakehasi, Maria Isabel T D Correia, Rosângela Teixeira, Dulciene M M Queiroz, Gifone A Rocha, Luciana D Silva
BACKGROUND: Preserved skeletal muscle is essential for the maintenance of healthy bone. Loss of bone mineral density (BMD) and muscle strength, considered a predictor of BMD, have been demonstrated in patients with cirrhosis, but they are poorly studied in chronic hepatitis C (CHC) without cirrhosis. Thus, we aimed to evaluate the prevalence of low BMD and its association with body composition, muscle strength, and nutritional status in CHC. METHODS: One hundred and four subjects [mean age, 50...
April 2018: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/29323441/a-low-muscle-mass-increases-mortality-in-compensated-cirrhotic-patients-with-sepsis
#14
Cristina Lucidi, Barbara Lattanzi, Vincenza Di Gregorio, Simone Incicco, Daria D'Ambrosio, Mario Venditti, Oliviero Riggio, Manuela Merli
BACKGROUND & AIMS: Severe infections and muscle wasting are both associated to poor outcome in cirrhosis. A possible synergic effect of these two entities in cirrhotic patients has not been previously investigated. We aimed at analysing if a low muscle mass may deteriorate the outcome of cirrhotic patients with sepsis. METHODS: Consecutive cirrhotic patients hospitalized for sepsis were enrolled in the study. Patients were classified for the severity of liver impairment (Child-Pugh class) and for the presence of "low muscle mass" (mid-arm muscle circumference<5th percentile)...
May 2018: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/29312971/impact-of-sarcopenic-overweight-on-the-outcomes-after-living-donor-liver-transplantation
#15
Ahmed Hammad, Toshimi Kaido, Yuhei Hamaguchi, Shinya Okumura, Atsushi Kobayashi, Hisaya Shirai, Naoko Kamo, Shintaro Yagi, Shinji Uemoto
Background: The effect of body composition disturbances has been recently in focus. Sarcopenic obesity, a co-occurrence of low muscle mass and high body fat was reportedly predictive of high mortality in patients with cirrhosis. However, the impact of the interacting sarcopenia and overweight on the outcomes after liver transplantation is still unclear. Methods: We evaluated 200 patients undergoing adult-to-adult living donor liver transplantation at our institution between January 2008 and November 2013 classified according to BMI and psoas muscle index (PMI) on admission to transplant into 4 subgroups; sarcopenic overweight (SO), sarcopenic non-overweight (SN), non-sarcopenic overweight and non-sarcopenic non-overweight (NN)...
December 2017: Hepatobiliary Surgery and Nutrition
https://www.readbyqxmd.com/read/29221886/a-model-including-sarcopenia-surpasses-the-meld-score-in-predicting-waiting-list-mortality-in-cirrhotic-liver-transplant-candidates-a-competing-risk-analysis-in-a-national-cohort
#16
Jeroen Laurens Ad van Vugt, Louise Johanna Maria Alferink, Stefan Buettner, Marcia Patricia Gaspersz, Daphne Bot, Sarwa Darwish Murad, Shirin Feshtali, Peter Martinus Adranius van Ooijen, Wojciech Grzegorz Polak, Robert Jack Porte, Bart van Hoek, Aad Pieter van den Berg, Herold J Metselaar, Jan Nicolaas Maria IJzermans
BACKGROUND & AIMS: Frail patients with low model for end-stage liver disease (MELD) scores may be under-prioritised. Low skeletal muscle mass, namely sarcopenia, has been identified as a risk factor for waiting list mortality. A recent study proposed incorporating sarcopenia in the MELD score (MELD-Sarcopenia score). We aimed to investigate the association between sarcopenia and waiting list mortality, and to validate the MELD-Sarcopenia score (i.e. MELD + 10.35 * Sarcopenia)...
December 6, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/29115717/changes-in-liver-function-and-body-composition-by-direct-acting-antiviral-therapy-for-hepatitis-c-virus-infection
#17
Ryosuke Sugimoto, Motoh Iwasa, Nagisa Hara, Yasuyuki Tamai, Kyoko Yoshikawa, Suguru Ogura, Hideaki Tanaka, Akiko Eguchi, Norihiko Yamamoto, Yoshinao Kobayashi, Hiroshi Hasegawa, Yoshiyuki Takei
AIM: Management of low skeletal muscle mass (LSM) is a very important topic as LSM affects patient mortality in liver diseases. Changes in body composition are unexplored in chronic hepatitis C virus (HCV) patients, including those with liver cirrhosis, who receive direct-acting antiviral (DAA) therapy. Body composition measurements and liver function tests were carried out before and after DAA therapy. METHODS: Blood examination, visceral fat area (VFA) and extremity skeletal muscle mass were measured using the multifrequency bioelectrical impedance analysis method: (i) at 24 weeks before DAA therapy; (ii) at the start of DAA therapy; (iii) at the end of DAA therapy; (iv) at 24 weeks after DAA therapy; and (v) at 48 weeks after DAA therapy...
April 2018: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/29059469/fat-free-muscle-mass-in-magnetic-resonance-imaging-predicts-acute-on-chronic-liver-failure-and-survival-in-decompensated-cirrhosis
#18
Michael Praktiknjo, Marius Book, Julian Luetkens, Alessandra Pohlmann, Carsten Meyer, Daniel Thomas, Christian Jansen, Andreas Feist, Johannes Chang, Jochen Grimm, Jennifer Lehmann, Christian P Strassburg, Juan Gonzalez Abraldes, Guido Kukuk, Jonel Trebicka
Muscle mass seems to be a prognostic marker in patients with liver cirrhosis. However, reported methods to quantify muscle mass are heterogeneous, consented cutoff values are missing, and most studies have used computed tomography. This study evaluated fat-free muscle area (FFMA) as a marker of sarcopenia using magnetic resonance imaging (MRI) in patients with decompensated cirrhosis with transjugular intrahepatic portosystemic shunt (TIPS). The total erector spinae muscle area and the intramuscular fat tissue area were measured and subtracted to calculate the FFMA in 116 patients with cirrhosis by TIPS and MRI...
March 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29035972/hyperammonemia-and-proteostasis-in-cirrhosis
#19
REVIEW
Srinivasan Dasarathy, Maria Hatzoglou
PURPOSE OF REVIEW: Skeletal muscle loss or sarcopenia is a frequent complication of cirrhosis that adversely affects clinical outcomes. As skeletal muscle is the largest store of proteins in the body, proteostasis or protein homeostasis is required for maintenance of muscle mass. This review will focus on disordered skeletal muscle proteostasis in liver disease. RECENT FINDINGS: Increased skeletal muscle uptake of ammonia initiates responses that result in disordered proteostasis including impaired protein synthesis and increased autophagy...
January 2018: Current Opinion in Clinical Nutrition and Metabolic Care
https://www.readbyqxmd.com/read/28984678/effect-of-branched-chain-amino-acid-supplements-on-muscle-strength-and-muscle-mass-in-patients-with-liver-cirrhosis
#20
Haruki Uojima, Seiko Sakurai, Hisashi Hidaka, Takeshi Kinbara, Ji Hyun Sung, Chikamasa Ichita, Shinnosuke Tokoro, Sakue Masuda, Akiko Sasaki, Kazuya Koizumi, Hideto Egashira, Makoto Kako, Shuzo Kobayashi
OBJECTIVE: The aim of this study was to assess the effect of branched-chain amino acid (BCAA) supplements on muscle strength and muscle mass in patients with liver cirrhosis. PATIENTS AND METHODS: We carried out a single-center, prospective study of adult cirrhotic patients receiving nutrition therapy at Shonan Kamakura General Hospital. A 28-day pretreatment observation period was followed by a 24-week treatment period. Patients who fulfilled the treatment criteria received one package of oral BCAA supplement powder twice a day and the response was evaluated...
December 2017: European Journal of Gastroenterology & Hepatology
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