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Culture-Bound Syndrome OR Dhat Syndrome

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https://www.readbyqxmd.com/read/30007092/upregulation-of-il-6-expression-in-human-salivary-gland-cell-line-by-il-17-via-activation-of-p38-mapk-erk-pi3k-akt-and-nf-%C3%AE%C2%BAb-pathways
#1
Lili Wei, Haofei Xiong, Wei Li, Bo Li, Yong Cheng
BACKGROUND: The human salivary gland (HSG) cell line has so far been used as in vitro models for study of the influence of cytokines and pharmacologic agents on salivary glands, as well as a model system for inflammation in Sjögren's syndrome (SS). This study aimed to determine the effect of IL-17 on IL-6 production and the underlying molecular mechanism regulated by the HSG cell line. METHODS: Immunofluorescence analyses, RT-PCR, and Western blot were conducted to evaluate the IL-17 receptor (IL-17R) expression in cultured HSG cells...
July 14, 2018: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/29956768/jag1-loss%C3%A2-of%C3%A2-function-mutations-contributed-to-alagille-syndrome-in-two-chinese-families
#2
Erge Zhang, Yuejuan Xu, Yongguo Yu, Sun Chen, Yu Yu, Kun Sun
Alagille syndrome (ALGS) is primarily caused by jagged1 (JAG1) mutations, 70% of which are protein‑truncating mutations. However, no mutation hotspots have been discovered, and the pathogenic mechanism is not fully understood. The aim of the present study was to analyze two protein‑truncating JAG1 mutations detected in three Chinese ALGS patients. Mutation c.1261delT (p.Cys421Valfs) was identified in one patient with hepatic damage, xanthomas, facial abnormalities and cardiovascular defects, which was inherited from his father...
August 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29953125/the-place-of-psychoanalysis-in-french-psychiatry
#3
Michel Botbol, Adeline Gourbil
France is known as one of the countries where psychoanalysis still holds an important position in various fields, and specially in psychiatry. Is it a 'culture bound syndrome' of French society, or, more seriously, a particularity that could be useful in other contexts as well? Through consideration of the role psychoanalysis is playing in French psychiatry, this paper will try to review this particularity and its interactions with the organisation and values of psychiatry in France, both in the public services and in private practice...
February 2018: BJPsych International
https://www.readbyqxmd.com/read/29803962/a-qualitative-study-on-psychopathology-of-dhat-syndrome-in-men-implications-for-classification-of-disorders
#4
Sathya Prakash, Pratap Sharan, Mamta Sood
BACKGROUND: Dhat syndrome is regarded by many as a culture bound syndrome of the Indian sub-continent. However the nosological status, conceptual understanding of the condition as well as the diagnostic guidelines are all mired in controversy. AIMS: The current study aims to study the psychopathology of Dhat syndrome in men by using a qualitative approach and to arrive at an operational definition for diagnosing Dhat syndrome. METHOD: The qualitative approach consisted of five Focus Group Discussions (FGD) and five Key Individual Interviews (KII) with participants, consisting of patients as well as doctors - both allopathic as well as traditional...
June 2018: Asian Journal of Psychiatry
https://www.readbyqxmd.com/read/29722492/-koro-syndrome-when-culture-interacts-with-psychopathology
#5
F Elghazouani, M Barrimi
Koro syndrome is a psychiatric disorder specific to certain Asian cultures. It is characterized by acute and intense anxiety with fear of a retraction of the penis into the body and resultant death. We report the case of a 43-year-old Moroccan male presenting with persistent anxiety associated with avoidance behaviors and a chronic belief that his genitalia may shrink or disappear and lead to his death. This impacted his professional and family functioning. The diagnosis of culture-bound syndrome was considered although the presenting syndrome was chronic and sporadic...
2018: Revue Médicale de Bruxelles
https://www.readbyqxmd.com/read/29616380/culture-and-the-trajectories-of-developmental-pathology-insights-from-control-and-information-theories
#6
Rodrick Wallace
Cognition in living entities-and their social groupings or institutional artifacts-is necessarily as complicated as their embedding environments, which, for humans, includes a particularly rich cultural milieu. The asymptotic limit theorems of information and control theories permit construction of a new class of empirical 'regression-like' statistical models for cognitive developmental processes, their dynamics, and modes of dysfunction. Such models may, as have their simpler analogs, prove useful in the study and re-mediation of cognitive failure at and across the scales and levels of organization that constitute and drive the phenomena of life...
June 2018: Acta Biotheoretica
https://www.readbyqxmd.com/read/29587413/multifaced-roles-of-the-%C3%AE-v%C3%AE-3-integrin-in-ehlers-danlos-and-arterial-tortuosity-syndromes-dermal-fibroblasts
#7
REVIEW
Nicoletta Zoppi, Nicola Chiarelli, Marco Ritelli, Marina Colombi
The αvβ3 integrin, an endothelial cells' receptor-binding fibronectin (FN) in the extracellular matrix (ECM) of blood vessels, regulates ECM remodeling during migration, invasion, angiogenesis, wound healing and inflammation, and is also involved in the epithelial mesenchymal transition. In vitro-grown human control fibroblasts organize a fibrillar network of FN, which is preferentially bound on the entire cell surface to its canonical α5β1 integrin receptor, whereas the αvβ3 integrin is present only in rare patches in focal contacts...
March 26, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29205354/podocytes-are-new-cellular-targets-of-haemoglobin-mediated-renal-damage
#8
Alfonso Rubio-Navarro, Maria Dolores Sanchez-Niño, Melania Guerrero-Hue, Cristina García-Caballero, Eduardo Gutiérrez, Claudia Yuste, Ángel Sevillano, Manuel Praga, Javier Egea, Elena Román, Pablo Cannata, Rosa Ortega, Isabel Cortegano, Belén de Andrés, María Luisa Gaspar, Susana Cadenas, Alberto Ortiz, Jesús Egido, Juan Antonio Moreno
Recurrent and massive intravascular haemolysis induces proteinuria, glomerulosclerosis, and progressive impairment of renal function, suggesting podocyte injury. However, the effects of haemoglobin (Hb) on podocytes remain unexplored. Our results show that cultured human podocytes or podocytes isolated from murine glomeruli bound and endocytosed Hb through the megalin-cubilin receptor system, thus resulting in increased intracellular Hb catabolism, oxidative stress, activation of the intrinsic apoptosis pathway, and altered podocyte morphology, with decreased expression of the slit diaphragm proteins nephrin and synaptopodin...
March 2018: Journal of Pathology
https://www.readbyqxmd.com/read/29162437/mouse-model-of-alagille-syndrome-and-mechanisms-of-jagged1-missense-mutations
#9
Emma R Andersson, Indira V Chivukula, Simona Hankeova, Marika Sjöqvist, Yat Long Tsoi, Daniel Ramsköld, Jan Masek, Aiman Elmansuri, Anita Hoogendoorn, Elenae Vazquez, Helena Storvall, Julie Netušilová, Meritxell Huch, Björn Fischler, Ewa Ellis, Adriana Contreras, Antal Nemeth, Kenneth C Chien, Hans Clevers, Rickard Sandberg, Vitezslav Bryja, Urban Lendahl
BACKGROUND & AIMS: Alagille syndrome is a genetic disorder characterized by cholestasis, ocular abnormalities, characteristic facial features, heart defects, and vertebral malformations. Most cases are associated with mutations in JAGGED1 (JAG1), which encodes a Notch ligand, although it is not clear how these contribute to disease development. We aimed to develop a mouse model of Alagille syndrome to elucidate these mechanisms. METHODS: Mice with a missense mutation (H268Q) in Jag1 (Jag1+/Ndr mice) were outbred to a C3H/C57bl6 background to generate a mouse model for Alagille syndrome (Jag1Ndr/Ndr mice)...
March 2018: Gastroenterology
https://www.readbyqxmd.com/read/29102762/immunoglobulins-from-sera-of-aps-patients-bind-htr-8-svneo-trophoblast-cell-line-and-reduce-additional-mediators-of-cell-invasion
#10
Milica Jovanović Krivokuća, Tamara Abu Rabi, Ivana Stefanoska, Svetlana Vrzić-Petronijević, Miloš Petronijević, Ljiljana Vićovac
Immunoglobulins from sera of patients with antiphospholipid syndrome (APS) decrease trophoblast cell invasion in vitro. This study aimed to extend understanding of cellular effects of immunoglobulins from APS (aPL+) in HTR-8/SVneo cells. aPL+ IgG induced change in effector molecules important for cell invasion was investigated further. After 1h of culture 21% cells bound aPL+ IgG, as opposed to 6% in control (aPL-). This was accompanied by increase in phospho-p38 at 30min. After 24h treatment aPL+IgG decreased protein levels of integrin subunits α1 (78% of control; p<0...
December 2017: Reproductive Biology
https://www.readbyqxmd.com/read/29082901/pattern-and-predictors-of-brain-fag-syndrome-among-senior-secondary-school-students-in-calabar-nigeria
#11
Emmanuel Aniekan Essien, Chidi John Okafor, Joseph Okegbe, Owoidoho Udofia
CONTEXT: Brain Fag syndrome (BFS) is a culture-bound disorder that is quite common among Nigerian students. It is known to be associated with study difficulty, and in severe cases, discontinuation of education. Little is known about its pattern and predictors among secondary school (SS) students in Calabar. AIMS: This study aims to determine the pattern and sociodemographic predictors of BFS among SS students in Calabar. PARTICIPANTS AND METHODS: Stratified sampling was used in this cross-sectional study to recruit 1091 students from ten SSs in Calabar metropolis...
July 2017: Nigerian Postgraduate Medical Journal
https://www.readbyqxmd.com/read/28955146/case-study-of-an-adopted-chinese-woman-with-bulimia-nervosa-a-cultural-and-transcultural-approach
#12
Marion Vu-Augier de Montgremier, Liangliang Chen, Jue Chen, Marie Rose Moro
For a long time, eating disorders were considered as culture-bound syndromes, specific to Western countries. This theory has been refuted for anorexia, but few transcultural studies have been carried out on bulimia nervosa. As a result, knowledge concerning this disorder is limited. On the basis of a clinical case involving a bulimic Chinese girl, we attempt to demonstrate the impact of cultural factors on the disorder. We discuss the atypical characteristics of her symptom profile, in particular the absence of preoccupations concerning her appearance and the psycho-pathological impact of the secrecy surrounding her adoption...
August 25, 2017: Shanghai Archives of Psychiatry
https://www.readbyqxmd.com/read/28852249/where-lies-the-fault-in-diagnosing-dhat-syndrome-among-females-understanding-through-a-case-study
#13
Sujita Kumar Kar, Amit Singh
Dhat syndrome is a culture-bound syndrome of South-East Asia, common in young men. However, similar entity has also been described in female patients who attribute their symptoms to nonpathological or physiological vaginal discharge. The current diagnostic system for psychiatric illnesses does not encompass Dhat syndrome in females, and so these group of patients receive alternative diagnoses such as somatoform disorder or depression. As a result of which the focus of unique Dhat syndrome-centered management gets weakened, affecting the clinical outcome...
July 2017: Indian Journal of Psychological Medicine
https://www.readbyqxmd.com/read/28845164/posttraumatic-embitterment-disorder-and-hwa-byung-in-the-general-korean-population
#14
Soohyun Joe, Jung Sun Lee, Seong Yoon Kim, Seung-Hee Won, Jong Seok Lim, Kyoo Seob Ha
OBJECTIVE: Posttraumatic embitterment disorder (PTED) is characterized by states of "embitterment", characteristically similar to "Hwa-byung", which is a Korean culture-bound syndrome. The present study aimed to assess diagnostic relationships between PTED and Hwa-byung. METHODS: A total of 290 participants completed our survey. PTED and Hwa-byung were diagnosed using a diagnostic interview and scale. Scales for depression, suicide ideation, and anger were used for evaluation...
July 2017: Psychiatry Investigation
https://www.readbyqxmd.com/read/28699998/culture-bound-syndromes-in-migratory-contexts-the-case-of-bolivian-immigrants
#15
María Teresa Roldán-Chicano, José Fernández-Rufete, César Hueso-Montoro, María Del Mar García-López, Javier Rodríguez-Tello, María Dolores Flores-Bienert
Objective: to describe the culture-bound syndromes maintained by Bolivian immigrants in the new migratory context and analyze the care processes of these health problems. Method: qualitative research with an ethnographic methodological approach. Sample: 27 Bolivian immigrants. In-depth interviews and participatory observation were the strategies used for data collection. Data were classified and categorized into logical schemes manually and using the ATLAS-ti program v...
July 10, 2017: Revista Latino-americana de Enfermagem
https://www.readbyqxmd.com/read/28623238/a-normal-genetic-variation-modulates-synaptic-mmp-9-protein-levels-and-the-severity-of-schizophrenia-symptoms
#16
Katarzyna Lepeta, Katarzyna J Purzycka, Katarzyna Pachulska-Wieczorek, Marina Mitjans, Martin Begemann, Behnam Vafadari, Krystian Bijata, Ryszard W Adamiak, Hannelore Ehrenreich, Magdalena Dziembowska, Leszek Kaczmarek
Matrix metalloproteinase 9 (MMP-9) has recently emerged as a molecule that contributes to pathological synaptic plasticity in schizophrenia, but explanation of the underlying mechanisms has been missing. In the present study, we performed a phenotype-based genetic association study (PGAS) in > 1,000 schizophrenia patients from the Göttingen Research Association for Schizophrenia (GRAS) data collection and found an association between the MMP-9 rs20544 C/T single-nucleotide polymorphism (SNP) located in the 3'untranslated region (UTR) and the severity of a chronic delusional syndrome...
August 2017: EMBO Molecular Medicine
https://www.readbyqxmd.com/read/28515154/progerin-sequestration-of-pcna-promotes-replication-fork-collapse-and-mislocalization-of-xpa-in-laminopathy-related-progeroid-syndromes
#17
Benjamin A Hilton, Ji Liu, Brian M Cartwright, Yiyong Liu, Maya Breitman, Youjie Wang, Rowdy Jones, Hui Tang, Antonio Rusinol, Phillip R Musich, Yue Zou
Hutchinson-Gilford progeria syndrome (HGPS) is a rare genetic disorder that is caused by a point mutation in the LMNA gene, resulting in production of a truncated farnesylated-prelamin A protein (progerin). We previously reported that XPA mislocalized to the progerin-induced DNA double-strand break (DSB) sites, blocking DSB repair, which led to DSB accumulation, DNA damage responses, and early replication arrest in HGPS. In this study, the XPA mislocalization to DSBs occurred at stalled or collapsed replication forks, concurrent with a significant loss of PCNA at the forks, whereas PCNA efficiently bound to progerin...
September 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28483078/clinical-course-and-treatment-outcome-of-koro-a-follow-up-study-from-a-koro-epidemic-reported-from-west-bengal-india
#18
Amitava Dan, Tanushree Mondal, Kaustav Chakraborty, Aditi Chaudhuri, Asish Biswas
BACKGROUND: Koro, as a culture bound syndrome is predominantly reported from Asian countries. There is dearth of well-designed research focussing on course and outcome of Koro. METHOD: In the index study, 64 consecutive consenting patients with symptoms of Koro reported in different disciplines of a tertiary care Government Hospital of West Bengal were recruited over a period of 3 months. They were treated by standard treatment protocol and followed up for next 3 months...
April 2017: Asian Journal of Psychiatry
https://www.readbyqxmd.com/read/28344031/culture-bound-syndromes-of-a-brazilian-amazon-riverine-population-tentative-correspondence-between-traditional-and-conventional-medicine-terms-and-possible-ethnopharmacological-implications
#19
E Pagani, J de F L Santos, E Rodrigues
ETHNOPHARMACOLOGICAL RELEVANCE: It is not always possible to correlate the "emic" terms to the "etic" ones during ethnopharmacological surveys, especially regarding those related to Culture-Bound Syndromes (CBS). Nevertheless, it is the role of ethnopharmacology to address these correlations, since they are the basis for the understanding of potential bioactives. AIM AND OBJECTIVES: This study reports the clinical manifestations and therapeutic resources used for the treatment of CBS among some riverine inhabitants of Brazilian Amazonia...
May 5, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28218671/human-scfvs-that-counteract-bioactivities-of-staphylococcus-aureus-tsst-1
#20
Thunchanok Rukkawattanakul, Nitat Sookrung, Watee Seesuay, Nattawat Onlamoon, Pornphan Diraphat, Wanpen Chaicumpa, Nitaya Indrawattana
Some Staphylococcus aureus isolates produced toxic shock syndrome toxin-1 (TSST-1) which is a pyrogenic toxin superantigen (PTSAg). The toxin activates a large fraction of peripheral blood T lymphocytes causing the cells to proliferate and release massive amounts of pro-inflammatory cytokines leading to a life-threatening multisystem disorder: toxic shock syndrome (TSS). PTSAg-mediated-T cell stimulation circumvents the conventional antigenic peptide presentation to T cell receptor (TCR) by the antigen-presenting cell (APC)...
February 17, 2017: Toxins
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