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Culture Syndrome

Toshinobu Yamagishi, Mayu Hikone, Kazuhiro Sugiyama, Takahiro Tanabe, Yasuhiro Wada, Michiko Furugaito, Yuko Arai, Yutaka Uzawa, Ryo Mizushima, Keisuke Kamada, Yasutomo Itakura, Shigekazu Iguchi, Atsushi Yoshida, Ken Kikuchi, Yuichi Hamabe
BACKGROUND: Gemella bergeri is one of the nine species of the genus Gemella and is relatively difficult to identify. We herein describe the first case of septic shock due to a Gemella bergeri coinfection with Eikenella corrodens. CASE PRESENTATION: A 44-year-old Asian man with a medical history of IgG4-related ophthalmic disease who was prescribed corticosteroids (prednisolone) presented to our hospital with dyspnea. On arrival, he was in shock, and a purpuric eruption was noted on both legs...
October 19, 2018: BMC Infectious Diseases
K Krause, R Sabat, E Witte-Händel, A Schulze, V Puhl, M Maurer, K Wolk
BACKGROUND: Schnitzler's syndrome (SchS) is a rare autoinflammatory disease characterized by urticarial exanthema, bone and joint alterations, fever and monoclonal gammopathy, which manifests mostly in the second half of life. It involves over-activation of the interleukin(IL)-1 system, but the exact pathophysiological pathways remain largely unknown. OBJECTIVE: This study aimed at the identification and characterization of pathogenetic players in SchS. METHODS: Blood parameters were quantified in SchS patients compared to healthy subjects and patients with psoriasis and hidradenitis suppurativa using ELISA...
October 19, 2018: British Journal of Dermatology
Rodrigo G Ducati, Rajesh K Harijan, Scott A Cameron, Peter C Tyler, Gary B Evans, Vern L Schramm
Campylobacter jejuni is a Gram-negative bacterium responsible for food-borne gastroenteritis and associated with Guillain-Barré, Reiter, and irritable bowel syndromes. Antibiotic resistance in C. jejuni is common, creating a need for antibiotics with novel mechanisms of action. Menaquinone biosynthesis in C. jejuni uses the rare futalosine pathway, where 5'-methylthioadenosine nucleosidase ( CjMTAN) is proposed to catalyze the essential hydrolysis of adenine from 6-amino-6-deoxyfutalosine to form dehypoxanthinylfutalosine, a menaquinone precursor...
October 19, 2018: ACS Chemical Biology
Joy Garrett, Carol H Sampson, P Artur Plett, Robin Crisler, Jeffrey Parker, Richard Venezia, Hui Lin Chua, Debra L Hickman, Catherine Booth, Thomas MacVittie, Christie M Orschell, Joseph R Dynlacht
Several investigators performing bone marrow transplantation studies have previously reported sporadic increases in mortality that were associated with pronounced swelling in the face, head and neck of mice. Over the past few years, we and others have noted an increasing number of experiments in which mice that have received total-body irradiation (TBI) or partial-body irradiation (PBI) develop swollen muzzles, drastic thickening of the upper lip and redness, bruising and/or swelling around the nose and muzzle and sometimes over the top of the head...
October 19, 2018: Radiation Research
Melat Solomon, Telake Azale, Awake Meherte, Getachew Asfaw, Getinet Ayano
Introduction: There is a cultural variability around the perception of what causes the syndrome of schizophrenia. As far as the cause of schizophrenia by the general public concerned, people living in western countries focus mainly on biological and social risk factors such as genetic vulnerability, disease of the brain, infection or stressful social conditions or personal weakness, but the predominant views held by people living in non-western countries focus mainly on supernatural and religious factors...
2018: Annals of General Psychiatry
Shuang Hou, Jie Hao, Yan-Yu Wang, Bing-Bing Zhao, Gong-Wei Xiao, Yan-Qing Li, Xi Liu, Zhi-Lan Zou, Ye Yao, Hong Xiong
The transcription factor, early B cell factor 1 (EBF1), plays a vital role in the lineage specification involving early B cell development and the onset of myelodysplastic syndrome (MDS). Therefore, to investigate whether or not EBF1 affects MDS as well as the transcription factor's underlying mechanism, we used CD34+ hematopoietic stem cells in bone marrow from patients with MDS. The extracted cells were then transfected with a series of EBF1, short hairpin RNA against EBF1 (shEBF1), and SB203580 (a specific mitogen-activated protein kinase [MAPK] axis inhibitor)...
October 18, 2018: Journal of Cellular Biochemistry
Nhora Silva, Natalia Calvache, Elizabeth Arrieta, Juan Carlos Bravo, Camilo Salazar, Joaquín Rosales, Francisco Jaramillo, Juan Guillermo Restrepo
The small lymphocytic lymphoma is a mature B cell neoplasm with a broad spectrum of clinical presentations. Opportunistic infections that are not related to the treatment, even in advanced stages, have a low incidence rate. There are few case reports in the medical literature of patients who have not received immunosuppressive therapy and present with small lymphocytic lymphoma associated with disseminated histoplasmosis at diagnosis. A female 82-year-old patient was admitted due to an intermittent dry cough, asthenia, and adynamia that had persisted for one month...
September 1, 2018: Biomédica: Revista del Instituto Nacional de Salud
Lena Pinzur, Levent Akyuez, Lilia Levdansky, Michal Blumenfeld, Evgenia Volinsky, Zami Aberman, Petra Reinke, Racheli Ofir, Hans-Dieter Volk, Raphael Gorodetsky
BACKGROUND: Most current cell-based regenerative therapies are based on the indirect induction of the affected tissues repair. Xenogeneic cell-based treatment with expanded human placenta stromal cells, predominantly from fetal origin (PLX-RAD cells), were shown to mitigate significantly acute radiation syndrome (ARS) following high dose irradiation in mice, with expedited regain of weight loss and haematopoietic function. The current mechanistic study explores the indirect effect of the secretome of PLX-RAD cells in the rescue of the irradiated mice...
October 18, 2018: Journal of Cachexia, Sarcopenia and Muscle
Hedwig Eisenbarth, Sandy Krammer, Bethany G Edwards, Kent A Kiehl, Craig Neumann
Valid measurement of psychopathic traits in females using the Psychopathy Checklist Revised (PCL-R) continues to be an under researched topic. Previous latent variable and other psychometric studies have raised questions concerning the structure and predictive effects of psychopathic traits in females. New cross-cultural research finds good support for a four-factor model of psychopathy in females and the predictive effects of the psychopathy factors (Declercq, Carter, & Neumann, 2015; Neumann, Hare, & Pardini, 2015)...
July 15, 2018: Personality and Individual Differences
Jeffrey D Brand, Ahmed Lazrak, John E Trombley, Ren-Jay Shei, A Timothy Adewale, Jennifer L Tipper, Zhihong Yu, Amit R Ashtekar, Steven M Rowe, Sadis Matalon, Kevin S Harrod
Severe influenza (IAV) infection can develop into bronchopneumonia and edema, leading to acquired respiratory distress syndrome (ARDS) and pathophysiology. Underlying causes for pulmonary edema and aberrant fluid regulation largely remain unknown, particularly regarding the role of viral-mediated mechanisms. Herein, we show that distinct IAV strains reduced the functions of the epithelial sodium channel (ENaC) and the cystic fibrosis transmembrane regulator (CFTR) in murine respiratory and alveolar epithelia in vivo, as assessed by measurements of nasal potential differences and single-cell electrophysiology...
October 18, 2018: JCI Insight
Aulia Rizka, Siti Setiati, Kuntjoro Harimurti, M Sadikin, Indra G Mansur
BACKGROUND: Alphacalcidol, a vitamin D analog, shows immune regulatory potency as it works on the macrophage and T cell to control inflammation and T cell dysregulation in elderly. None has been known about its effect on elderly with various states of frailty syndrome, which have different level of chronic low grade inflammation. This study aimed to determine the effect of alphacalcidol on inflammatory cytokines (IL-6, IL-10, g-IFN ) and T cell subsets (CD4/CD8 ratio and CD8+ CD28-) of elderly with various stages of frailty syndrome...
July 2018: Acta Medica Indonesiana
Andrew M Borman, Adrien Szekely, Mark Fraser, Simon Lovegrove, Elizabeth M Johnson
A novel dermatophyte was isolated from skin scales of a female patient presenting with tinea corporis of the wrist and arm. Her principal risk factor was long-term corticosteroid use for underlying Lupus autoimmune syndrome. Microscopic examination of skin scales from lesions revealed hyphae consistent with dermatophyte infection, and a morphologically identical fungus grew in pure culture on all cultures of skin scales. Repeat isolation of the same organism from persistent lesions five months later confirmed the novel species as the causative agent...
October 16, 2018: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
Ethan Moitra, Yovanska Duarte-Velez, Roberto Lewis-Fernández, Risa B Weisberg, Martin B Keller
BACKGROUND: Ataque de nervios (ataque) represents a cultural syndrome of paroxysmic symptoms that is described as an expression of distress among Latinx (gender-inclusive term for people of Latin-American descent). Some ataques are symptomatically similar to DSM-5-defined panic attacks, but also may include acute anger, grief, suicidal/violent behavior, or dissociation, and can last for hours or even days. Ataques usually occur after stressors and can trigger the mobilization of social support networks...
October 17, 2018: Depression and Anxiety
Jayne P Ellis, Newton Kalata, Elizabeth C Joekes, Samuel Kampondeni, Laura A Benjamin, Thomas S Harrison, David G Lalloo, Robert S Heyderman
BACKGROUND: Cryptococcal meningitis remains the leading cause of adult meningitis in Sub-Saharan Africa. Immune Reconstitution Inflammatory Syndrome (IRIS) following anti-retroviral therapy (ART) initiation is an important complication. Here we report the first documented case of a IRIS reaction presenting as an ischemic stroke. CASE PRESENTATION: A 38 year old newly diagnosed HIV-infected, ART naive Malawian male presented to a tertiary referral hospital in Blantyre, Malawi with a 2 week history of headache...
October 16, 2018: BMC Infectious Diseases
Changbin Zhu, Dana A M Mustafa, Merle M Krebber, Ihsan Chrifi, Pieter J M Leenen, Dirk J Duncker, Lennard Dekker, Theo M Luider, Johan M Kros, Caroline Cheng
Introduction: Tumor associated macrophages (TAMs) promote tumor development, angiogenesis and distal metastasis. In previous studies, we showed that Cat Eye Syndrome Critical Region Protein 1 (CECR1) is expressed by M2-like TAMs in human glioma samples. CECR1 promoted M2 TAMs differentiation and affected glioma cell proliferation and migration. Here we investigated the proteomic profile of TAMs expressing CECR1 in absence or presence of glioma cells. Results: CECR1 siRNA transfection upregulated 67 proteins in THP-1-derived Macrophages (MQs)...
September 11, 2018: Oncotarget
Fengtao Luo, Yangli Xie, Zuqiang Wang, Junlan Huang, Qiaoyan Tan, Xianding Sun, Fangfang Li, Can Li, Mi Liu, Dali Zhang, Meng Xu, Nan Su, Zhenhong Ni, Wanling Jiang, Jinhong Chang, Hangang Chen, Shuai Chen, Xiaoling Xu, Chuxia Deng, Zhugang Wang, Xiaolan Du, Lin Chen
Apert syndrome (AS), the most severe form of craniosynostosis, is caused by missense mutations including Pro253Arg(P253R) of fibroblast growth factor receptor 2 (FGFR2), which leads to enhanced FGF/FGFR2-signaling activity. Surgical correction of the deformed skull is the typical treatment for AS. Because of constant maldevelopment of sutures, the corrective surgery is often executed several times, resulting in increased patient challenge and complications. Biological therapies targeting the signaling of mutant FGFR2 allele, in combination with surgery, may bring better outcome...
September 22, 2018: Molecular Therapy. Nucleic Acids
Xiaoxue Zhang, Jin Shang, Xiaoyang Wang, Genyang Cheng, Yumin Jiang, Dong Liu, Jing Xiao, Zhanzheng Zhao
Diabetic nephropathy (DN) is a highly complex syndrome involving multiple dysregulated biological processes. Long non‑coding RNAs (lncRNAs) are now believed to have an important function in various diseases. However, their roles in DN remain largely unknown. Therefore, the present study was performed in order to investigate the lncRNAs that have a crucial role in DN. db/db mice were used as a DN model while db/m mice served as a control to search for lncRNAs which may have important roles in DN. Microarray and bioinformatics analysis gave an overview of the features of differentially expressed genes...
October 4, 2018: Molecular Medicine Reports
Roberto Romero, Nardhy Gomez-Lopez, Juan Pedro Kusanovic, Percy Pacora, Bogdan Panaitescu, Offer Erez, Bo Hyun Yoon
Clinical chorioamnionitis is the most common infection related diagnosis made in labor and delivery units worldwide. It is traditionally believed to be due to microbial invasion of the amniotic cavity, which elicits a maternal inflammatory response characterized by maternal fever, uterine tenderness, maternal tachycardia and leukocytosis. The condition is often associated with fetal tachycardia and a foul smelling amniotic fluid. Recent studies in which amniocentesis has been used to characterize the microbiologic state of the amniotic cavity and the inflammatory response show that only 60% of patients with the diagnosis of clinical chorioamnionitis have proven infection using culture or molecular microbiologic techniques...
June 2018: Nőgyógyászati és szülészeti továbbképző szemle
Sara Castagnola, Sébastien Delhaye, Alessandra Folci, Agnès Paquet, Frédéric Brau, Fabrice Duprat, Marielle Jarjat, Mauro Grossi, Méline Béal, Stéphane Martin, Massimo Mantegazza, Barbara Bardoni, Thomas Maurin
Fragile X syndrome (FXS), the most common form of inherited intellectual disability (ID) and a leading cause of autism, results from the loss of expression of the Fmr1 gene which encodes the RNA-binding protein Fragile X Mental Retardation Protein (FMRP). Among the thousands mRNA targets of FMRP, numerous encode regulators of ion homeostasis. It has also been described that FMRP directly interacts with Ca2+ channels modulating their activity. Collectively these findings suggest that FMRP plays critical roles in Ca2+ homeostasis during nervous system development...
2018: Frontiers in Molecular Neuroscience
L Marcellus
AIM: To describe the current state of evidence on the care of neonates with neonatal abstinence syndrome in countries with low to virtually no medical opioid analgesic consumption. BACKGROUND: While access to opioids for medical use improves globally, misuse grows as a health concern. One unintended consequence has been an increase in the incidence of neonatal abstinence syndrome. Because most evidence is generated in countries with adequate opioid analgesic consumption, a picture of evidence in lower opioid-consuming countries is not available...
October 14, 2018: International Nursing Review
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