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https://www.readbyqxmd.com/read/30337252/new-5-factor-modified-frailty-index-predicts-morbidity-and-mortality-in-primary-hip-and-knee-arthroplasty
#1
Sophia A Traven, Russell A Reeves, Molly G Sekar, Harris S Slone, Zeke J Walton
BACKGROUND: While the 11-factor modified frailty index (mFI) has been shown to predict adverse outcomes in patients undergoing total joint arthroplasty, the 5-factor index has not been evaluated in this patient population. The goal of this study was to evaluate the utility of the mFI-5 as a predictor of morbidity and mortality in patients undergoing primary total hip and knee arthroplasty. METHODS: A retrospective analysis of the American College of Surgeons National Surgical Quality Improvement Program's database for patients undergoing total hip arthroplasty and total knee arthroplasty between the years 2005 and 2016 was conducted...
September 21, 2018: Journal of Arthroplasty
https://www.readbyqxmd.com/read/30309449/relationships-between-abdominal-aortic-calcification-glomerular-filtration-rate-and-cardiovascular-risk-factors-in-patients-with-non-dialysis-dependent-chronic-kidney-disease
#2
Yunan Zhou, Matthias Hellberg, Evangelia Kouidi, Asterios Deligiannis, Peter Höglund, Naomi Clyne
BACKGROUND: Abdominal aortic calcification (AAC) is an established risk factor for cardiovascular events in patients with chronic kidney disease (CKD). We hypothesized that AAC is associated with a decline in glomerular filtration rate (GFR) as well as with some other cardiovascular risk factors. MATERIALS AND METHODS: This is a cross-sectional analysis of baseline data from a randomized controlled clinical trial (RENEXC). A total of 151 patients (aged 66 ± 14 years) with an average measured GFR (mGFR) of 22...
October 12, 2018: Clinical Nephrology
https://www.readbyqxmd.com/read/30304456/frequency-and-associations-of-prescription-nonsteroidal-anti-inflammatory-drug-use-among-patients-with-a-musculoskeletal-disorder-and-hypertension-heart-failure-or-chronic-kidney-disease
#3
Zachary Bouck, Graham C Mecredy, Noah M Ivers, Moumita Barua, Danielle Martin, Peter C Austin, Joshua Tepper, R Sacha Bhatia
Importance: International nephrology societies advise against nonsteroidal anti-inflammatory drug (NSAID) use in patients with hypertension, heart failure, or chronic kidney disease (CKD); however, recent studies have not investigated the frequency or associations of use in these patients. Objectives: To estimate the frequency of and variation in prescription NSAID use among high-risk patients, to identify characteristics associated with prescription NSAID use, and to investigate whether use is associated with short-term, safety-related outcomes...
October 8, 2018: JAMA Internal Medicine
https://www.readbyqxmd.com/read/30293929/short-term-heart-rate-variability-as-a-predictor-of-long-term-survival-in-patients-with-chronic-hemodialysis-a-prospective-cohort-study
#4
George Kuo, Szi-Wen Chen, Jeng-Yi Huang, Chao-Yi Wu, Chung-Ming Fu, Chih-Hsiang Chang, Su-Hsun Liu, Yi-Hsin Chan, I-Wen Wu, Huang-Yu Yang
BACKGROUND: Heart rate variability (HRV), a non-invasive measurement of the sympathetic-vagal balance, has been demonstrated as a predictor of long-term survival in various patient populations. However, its predictive value in patients with end-stage renal disease (ESRD) has not been evaluated in a long-term follow-up study. METHODS: Prospective data collected for 41 patients with chronic hemodialysis (age 59 ± 10 years, men 51.3%, diabetes mellitus 31%, and duration of dialysis 64 ± 50 months) who underwent a 5-minute electrocardiogram (ECG) recording as a baseline for frequency domain HRV analysis...
October 5, 2018: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/30279886/limited-effects-of-long-term-enzyme-replacement-therapy-on-the-cardiac-conduction-system-in-fabry-disease
#5
Tomoya Kaneda, Masahiro Takeda, Tetsuro Suematsu, Ryusuke Yamamoto, Mutsuko Takata, Toshinori Higashikata, Hidekazu Ino, Akihiko Tsujibata, Kenshi Hayashi, Noboru Fujino, Masa-Aki Kawashiri
The long-term effects of enzyme replacement therapy (ERT) on cardiac function and the conduction system in Fabry disease are not clearly understood. We report a case of a 48-year-old man with non-classical Fabry disease treated with ERT for 11 years. He was diagnosed with Fabry disease at age 27 years based on the presence of decreased alpha-galactosidase A activity in the peripheral leukocytes and of the causal alpha-galactosidase A mutation (Val339Gln). Subsequently, peritoneal dialysis was initiated for renal failure at age 35 years...
May 2018: Journal of Cardiology Cases
https://www.readbyqxmd.com/read/30269828/recanalization-of-chronic-total-occlusions-in-patients-with-vs-without-chronic-kidney-disease-the-impact-of-contrast-induced-acute-kidney-injury
#6
Lorenzo Azzalini, Soledad Ojeda, Ozan M Demir, Joseph Dens, Masaki Tanabe, Alessio La Manna, Susanna Benincasa, Barbara Bellini, Enrico Poletti, Davide Maccagni, Francisco Hidalgo, Jorge Chavarría, Joren Maeremans, Giacomo Gravina, Eligio Miccichè, Guido D'Agosta, Giuseppe Venuti, Corrado Tamburino, Manuel Pan, Mauro Carlino, Antonio Colombo
BACKGROUND: Chronic total occlusion (CTO) percutaneous coronary intervention (PCI) is associated with high contrast volumes, which can be particularly deleterious in patients with chronic kidney disease (CKD). We aimed to study the outcomes of CTO PCI in subjects with vs without CKD, and the impact of contrast-induced acute kidney injury (CI-AKI). METHODS: This multicentre registry included patients who underwent CTO PCI at 5 centres. CI-AKI was defined as an increase in serum creatinine ≥0...
October 2018: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/30248953/blood-fatty-acid-status-and-clinical-outcomes-in-dialysis-patients-a-systematic-review
#7
REVIEW
Ban-Hock Khor, Sreelakshmi Sankara Narayanan, Karuthan Chinna, Abdul Halim Abdul Gafor, Zulfitri Azuan Mat Daud, Pramod Khosla, Kalyana Sundram, Tilakavati Karupaiah
Blood fatty acids (FAs) are derived from endogenous and dietary routes. Metabolic abnormalities from kidney dysfunction, as well as cross-cultural dietary habits, may alter the FA profile of dialysis patients (DP), leading to detrimental clinical outcomes. Therefore, we aimed to (i) summarize FA status of DP from different countries, (ii) compare blood FA composition between healthy controls and DP, and (iii) evaluate FA profile and clinical endpoints in DP. Fifty-three articles from 1980 onwards, reporting FA profile in hemodialysis and peritoneal DP, were identified from PubMed, Embase, and the Cochrane library...
September 21, 2018: Nutrients
https://www.readbyqxmd.com/read/30248947/syncope-and-collapse-are-associated-with-an-increased-risk-of-cardiovascular-disease-and-mortality-in-patients-undergoing-dialysis
#8
Shih-Ting Huang, Tung-Min Yu, Tai-Yuan Ke, Ming-Ju Wu, Ya-Wen Chuang, Chi-Yuan Li, Chih-Wei Chiu, Cheng-Li Lin, Wen-Miin Liang, Tzu-Chieh Chou, Chia-Hung Kao
Objective : This study explored the impact of syncope and collapse (SC) on cardiovascular events and mortality in patients undergoing dialysis. Methods : Patients undergoing dialysis with SC ( n = 3876) were selected as the study cohort and those without SC who were propensity score-matched at a 1:1 ratio were included as controls. Major adverse cardiovascular events (MACEs), including acute coronary syndrome (ACS), arrhythmia or cardiac arrest, stroke, and overall mortality, were evaluated and compared in both cohorts...
September 21, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/30244842/-lysozyme-amyloidosis
#9
M Scafi, S Valleix, A Benyamine, E Jean, J-R Harlé, P Rossi, L Daniel, N Schleinitz, B Granel
Lysozyme amyloidosis is a non-neuropathic hereditary amyloidosis identified in 1993. About fifty cases of this rare, probably under-diagnosed disease are reported. Lysozyme amyloidosis has a very broad spectrum of clinical manifestations. Sicca syndrome is often the first symptom, preceding the diagnosis by several years. Every part of the digestive tract can be involved with different grades of severity. The hallmark of this amyloidosis is the usually life-threatening spontaneous hepatic rupture. Renal involvement is frequent and progresses towards end-stage renal failure and dialysis...
September 20, 2018: La Revue de Médecine Interne
https://www.readbyqxmd.com/read/30243768/a-cost-effectiveness-analysis-of-rabbit-antithymocyte-globulin-versus-antithymocyte-globulin-fresenius-as-induction-therapy-for-patients-with-kidney-transplantation-from-donation-after-cardiac-death-in-china
#10
Dennis Xuan, Guodong Chen, Changxi Wang, XingXing Yao, Hongjun Yin, Lei Zhang, Jianwei Xuan, Lizhong Chen
PURPOSE: Induction immunosuppression therapy is used to support optimal outcomes in kidney transplantation. This study was to assess the cost-effectiveness of rabbit antithymocyte globulin (r-ATG) versus ATG-Fresenius (ATG-F) in kidney transplantation in the Chinese setting from the perspective of the health care payer. METHODS: A 2-part survival model was developed, consisting of a short-term part and a long-term part. The short-term part analyzed the first year, using the decision tree, and consisted of the functioning transplant, acute rejection (AR), delayed graft function (DGF), dialysis, and death health states...
September 20, 2018: Clinical Therapeutics
https://www.readbyqxmd.com/read/30236527/preoperative-venoarterial-extracorporeal-membrane-oxygenation-slashes-risk-score-in-advanced-structural-heart-disease
#11
A Claire Watkins, Nathan L Maassel, Mehrdad Ghoreishi, Murtaza Y Dawood, Si M Pham, Zachary N Kon, Bradley S Taylor, Bartley P Griffith, James S Gammie
BACKGROUND: Cardiac surgery for structural heart disease has poor outcomes in the presence of cardiogenic shock or advanced heart failure. We applied venoarterial extracorporeal membrane oxygenation (ECMO) to restore end-organ function and resuscitate patients before high-risk cardiac operation. METHODS: Twelve patients with cardiogenic shock and end-organ failure were evaluated for cardiac surgery. The average Society of Thoracic Surgeons (STS) mortality risk was 24% (±13)...
September 17, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/30235441/cardiac-troponin-t-risk-stratification-model-predicts-all-cause-mortality-following-kidney-transplant
#12
Christine Firth, Fadi Shamoun, Stephen Cha, Nan Zhang, Salma Patel, Paul Wennberg, Hatem Amer, Hani Wadei, Raymond Heilman, Mira Keddis
BACKGROUND: We evaluated the role of increased cardiac troponin T (cTnT), vascular, and cardiac diseases in predicting 5 and 10-year all-cause mortality after kidney transplantation. METHODS: We reviewed a cohort of 764 kidney transplant recipients and analyzed pertinent cardiovascular risk factors at the time of transplant evaluation. Proportional hazards regression analysis with bootstrapping method was utilized to provide a risk stratification score for mortality...
September 20, 2018: American Journal of Nephrology
https://www.readbyqxmd.com/read/30225901/sudden-cardiac-arrest-in-end-stage-renal-disease-patients-on-dialysis-a-nationwide-study
#13
Fahad Alqahtani, Ahmed Almustafa, Kuldeep Shah, Yasir Akram, Danish Abbasi, Rohit Rattan, Navin Subrayappa, Mohamad Alkhouli, Muhammad Bilal Munir
BACKGROUND: Sudden cardiac arrest (SCA) is frequently encountered in end-stage renal disease (ESRD) patients on dialysis. There is a dearth of national data on SCA-associated outcomes in this specific patient population. The aim of the present study is to study these parameters from a nationally representative US population. METHODS: Data were extracted from National Inpatient Sample database from October 2005 to December 2014. All patients with clinical encounter of dialysis during the study period were enrolled...
September 17, 2018: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/30223792/effects-of-pretransplant-peritoneal-vs-hemodialysis-modality-on-outcome-of-first-kidney-transplantation-from-donors-after-cardiac-death
#14
Xiajing Che, Xiaoqian Yang, Jiayi Yan, Yanhong Yuan, Qing Ma, Liang Ying, Minfang Zhang, Qin Wang, Ming Zhang, Zhaohui Ni, Shan Mou
BACKGROUND: The effect of pretransplant peritoneal dialysis (PD) or hemodialysis (HD) modality on outcomes of kidney transplantation (KT) for end-stage renal disease (ESRD) is debatable. We evaluated the outcomes these modalities in KT from donor after cardiac death (DCD). METHODS: A cohort of 251 patients on HD, PD or pre-emptive who underwent first KT from DCD between January 2014 and December 2016 were prospectively analyzed to compare for outcomes on recovery of renal function, complications as well as patient and graft survival...
September 17, 2018: BMC Nephrology
https://www.readbyqxmd.com/read/30219338/analysis-of-emergency-department-frequentation-among-patients-with-advanced-ckd-chronic-kidney-disease-lessons-to-optimise-scheduled-renal-replacement-therapy-initiation
#15
Víctor Lorenzo Sellarés
The decision to initiate renal replacement therapy (RRT) implies a wide margin of uncertainty. Glomerular filtration rate (GFR) tells us the magnitude of renal damage. Proteinuria indicates the speed of progression. However, nowadays more than 50% of patients are still initiating RRT hastily, and it is life threatening. HYPOTHESIS: By analysing Emergency Department (ED) frequentation and causes of a hurried initiation, we can better schedule the timing of the start of RRT. METHOD: Retrospective and observational study of all CKD patients in our outpatient clinic...
September 12, 2018: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
https://www.readbyqxmd.com/read/30214810/a-fatal-case-of-ortner-s-syndrome-and-dysphagia-aortica-secondary-to-rapidly-expanding-mycotic-thoracic-aortic-aneurysm-in-a-chronic-kidney-disease-patient
#16
Wynn Aung Kyaw, Chiao Yuen Lim, Muhammad Abdul Mabood Khalil, Kian Chai Lim, Vui Heng Chong, Jackson Tan
Ortner's syndrome or cardiovocal syndrome is a rare condition and refers to the association between cardiovascular conditions, usually cardiac enlargement from mitral stenosis, and recurrent laryngeal nerve palsy. We reported an interesting case of a patient with end-stage renal disease on regular dialysis who developed both Ortner's syndrome and dysphagia aortica as a result of an aortic arch aneurysm. The aneurysm underwent a rapid increase in size, likely as a result of Staphylococcus aureus infection (mycotic aneurysm) from an internal jugular dialysis catheter...
2018: SAGE Open Medical Case Reports
https://www.readbyqxmd.com/read/30196559/contrast-volume-to-estimated-glomerular-filtration-rate-ratio-for-prediction-of-contrast-induced-acute-kidney-injury-after-cardiac-catheterization-in-adults-with-congenital-heart-disease
#17
Laura Gellis, Kimberlee Gauvreau, Michael Ferguson, Lisa Bergersen, Keri Shafer, Diego Porras
BACKGROUND: Adults with congenital heart disease (ACHD) are vulnerable to contrast-induced acute kidney injury (CI-AKI) after cardiac catheterization. The aim of this study was to identify risk factors for clinically significant CI-AKI and evaluate the predictive value of contrast volume to estimated glomerular filtration rate ratio (V/eGFR) for the risk of CI-AKI following catheterization in the ACHD population. METHODS: ACHD patients who underwent catheterization at Boston Children's hospital between 1/2011 and 1/2017 were retrospectively analyzed...
September 9, 2018: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/30186632/vascular-calcification-in-chronic-kidney-disease-the-role-of-inflammation
#18
REVIEW
Kerstin Benz, Karl-Friedrich Hilgers, Christoph Daniel, Kerstin Amann
Cardiovascular complications are extremely frequent in patients with chronic kidney disease (CKD) and death from cardiac causes is the most common cause of death in this particular population. Cardiovascular disease is approximately 3 times more frequent in patients with CKD than in other known cardiovascular risk groups and cardiovascular mortality is approximately 10-fold more frequent in patients on dialysis compared to the age- and sex-matched segments of the nonrenal population. Among other structural and functional factors advanced calcification of atherosclerotic plaques as well as of the arterial and venous media has been described as potentially relevant for this high cardiovascular morbidity and mortality...
2018: International Journal of Nephrology
https://www.readbyqxmd.com/read/30186614/the-risk-of-adverse-events-in-patients-with-polycystic-kidney-disease-with-advanced-chronic-kidney-disease
#19
Sonali de Chickera, Ayub Akbari, Adeera Levin, Mila Tang, Pierre Brown, Ognjenka Djurdev, Mohan Biyani, Edward G Clark, Manish M Sood
Background: Polycystic kidney disease (PKD) leads to progressive chronic kidney disease (CKD) with a subsequent risk of adverse events such as cardiac disease, infections, end-stage kidney disease (ESKD), and mortality. Objectives: To determine the risks of CKD-related adverse outcomes in patients with PKD compared with patients without PKD. Setting: Canadian study of prediction of death, dialysis and interim cardiovascular events (CanPREDDICT) was a prospective pan-Canadian cohort study from 2008-2013 involving 28 facilities with adjudicated outcomes...
2018: Canadian Journal of Kidney Health and Disease
https://www.readbyqxmd.com/read/30173723/renal-transplantation-delays-major-adverse-cardiac-events-maces-in-patients-with-end-stage-renal-disease-a-nationwide-population-based-study
#20
Hsien-Tzung Liao, Ming-Chin Lin, Chang-Youh Tsai, Chien-Yeh Hsu, Tsai-Hung Wu
BACKGROUND: Whether renal transplantation (RT) influences the risk of cardiovascular events remains controversial. METHODS: This nationwide population-based study investigated the risk of major adverse cardiac events (MACEs) and stroke after RT in patients with end-stage renal disease (ESRD), using data obtained from the National Health Insurance Research Database in Taiwan. A total of 164 ESRD patients who underwent RT formed the study cohort, and an age- and sex-matched control group comprised 164 patients without RT selected from 6976 ESRD patients...
September 2018: Journal of the Chinese Medical Association: JCMA
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