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Chronic kidney disease cardiovascular

Chun-Fu Lai, Yen-Ting Chen, Jian Gu, Jeanne M Nerbonne, Chin-Hsien Lin, Kai-Chien Yang
BACKGROUND: Cardiovascular (CV) diseases are major causes of mortality in uremic patients. Conventional risk factors fail to identify uremic patients with increased propensity for adverse CV outcomes. We aimed to test the hypothesis that circulating long noncoding RNAs (lncRNAs) could be a prognostic marker to predict adverse CV outcomes in uremic patients. METHODS AND RESULTS: Plasma lncRNAs were profiled in patients with end-stage renal disease (ESRD, n = 28) or chronic kidney disease (CKD, n = 8) and in healthy (n = 12) subjects by RNA sequencing...
August 7, 2018: International Journal of Cardiology
Dagmara McGuinness, Suhaib Mohammed, Laura Monaghan, Paul A Wilson, David B Kingsmore, Oliver Shapter, Karen S Stevenson, Shana M Coley, Luke Devey, Robert B Kirkpatrick, Paul G Shiels
Chronic kidney disease and associated comorbidities (diabetes, cardiovascular diseases) manifest with an accelerated ageing phenotype, leading ultimately to organ failure and renal replacement therapy. This process can be modulated by epigenetic and environmental factors which promote loss of physiological function and resilience to stress earlier, linking biological age with adverse outcomes post-transplantation including delayed graft function (DGF). The molecular features underpinning this have yet to be fully elucidated...
August 9, 2018: Aging Cell
Keith Gillis, Kathryn K Stevens, Elizabeth Bell, Rajan K Patel, Alan G Jardine, Scott T W Morris, Markus P Schneider, Christian Delles, Patrick B Mark
Background: Premature cardiovascular disease in patients with chronic kidney disease (CKD) is not explained by traditional risk factors and oxidative stress may contribute via endothelial and vascular dysfunction. We investigated the effect of ascorbic acid on oxidative stress and vascular function in CKD patients compared with controls with hypertension (HTN). Methods: A crossover study of intravenous saline and ascorbic acid was conducted. Biomarkers of oxidative stress were measured, while pulse wave analysis and brachial flow - mediated dilatation were performed to assess large artery and endothelial function...
August 2018: Clinical Kidney Journal
Salih Karahan, Baris Afsar, Mehmet Kanbay
Asymmetric dimethylarginine (ADMA), an endogenous nitric oxide synthase inhibitor, is related with impaired endothelial function and poor outcomes in chronic kidney disease (CKD) patients. In addition, oxidative stress and inflammation are also a common problem in CKD patients, and both have an important role in the development and progression of atherosclerosis and increased cardiovascular events in CKD. Ascorbic acid might be a promising agent in CKD for improving outcome by decreasing oxidative stress and ADMA levels...
August 2018: Clinical Kidney Journal
Tiago Lemos Cerqueira, Armando Fartolino Guerrero, Clara Krystal Pérez Fermin, Ricardo Wang, Evelin Elfriede Balbino, Janis L Breeze, Paola Gonzalez Mego, Daniele Argentina Silva, Walid Ezzeldin Omer, Nathalie Monique Vandevelde
BACKGROUND: End-stage renal disease (ESRD) is the last stage of chronic kidney disease, mainly caused by type 2 diabetes mellitus and characterized by an increased mortality risk related to cardiovascular disease. Low-dose aspirin (acetylsalicylic acid or ASA) seems to effectively prevent cardiovascular events in patients with ESRD. However, the number of interventional studies in this population remains limited and the mechanisms of aspirin-related bleeding remain poorly understood. Aspirin's efficacy and safety may be modified by the presence of type 2 diabetes mellitus or platelet hyperreactivity...
August 9, 2018: JMIR Research Protocols
Ana Luiza Teixeira Dos Santos, Camila Kummel Duarte, Manoella Santos, Maira Zoldan, Jussara Carnevalle Almeida, Jorge Luiz Gross, Mirela Jobim Azevedo, Alice Hinda Lichtenstein, Themis Zelmanovitz
AIM: This cross-sectional study aimed to assess the association of the fat content in the diet with Diabetic Kidney Disease (DKD) in patients with type 2 diabetes. METHODOLOGY: Patients from the Diabetes research clinic at Hospital de Clínicas de Porto Alegre (Brazil) were consecutively recruited. The inclusion criterion was the diagnosis of type 2 diabetes. The exclusion criteria were as follows: body mass index >40 kg/m2, heart failure, gastroparesis, diabetic diarrhea, dietary counseling by a registered dietitian during the previous 12 months, and inability to perform the weighed diet records (WDR)...
2018: PloS One
Paulo G de Albuquerque Suassuna, Helady Sanders-Pinheiro, Rogério B de Paula
Cardiovascular diseases are the main cause of death in chronic kidney disease (CKD) patients. In dialysis patients, sudden cardiac death accounts for 40% of all deaths. In these patients, sudden cardiac death is usually secondary to an underlying cardiomyopathy, which is clinically identified by the high prevalence of left ventricular hypertrophy and the resultant mechanical and electrical dysfunction. CKD-related cardiomyopathy has a multifactorial pathophysiology. Recent evidence has highlighted the central pathophysiological role of chronic kidney disease-mineral and bone disorder (CKD-MBD) with hyperphosphatemia and high fibroblast growth factor 23 (FGF23) levels in these patients...
2018: Frontiers in Medicine
Jamil Ibrahim, Azzour D Hazzan, Anna T Mathew, Vipul Sakhiya, Meng Zhang, Candice Halinski, Steven Fishbane
Background: Late-stage chronic kidney disease (LS-CKD) can be defined by glomerular filtration rate (GFR) 0-30 mL/min. It is a period of risk for medication discrepancies because of frequent hospitalizations, fragmented medical care, inadequate communication and polypharmacy. In this study, we sought to characterize medication discrepancies in LS-CKD. Methods: We analyzed all patients enrolled in Northwell Health's Healthy Transitions in LS-CKD program. All patients had estimated GFR 0-30 mL/min, not on dialysis...
August 2018: Clinical Kidney Journal
Gregory A Nichols, Sephy Philip, Kristi Reynolds, Craig B Granowitz, Maureen O'Keeffe-Rosetti, Sergio Fazio
High triglyceride (TG) levels are associated with higher medical costs, but the long-term impact of high TG on costs among patients with statin-controlled low-density lipoprotein cholesterol (LDL-C) is unclear. We compared medical utilization and costs over 6.5 years between patients with high (200 to 400 mg/dl) versus normal (<150 mg/dl) TG levels, all of whom had established atherosclerotic cardiovascular disease (ASCVD). This was an observational cohort study of 17,183 patients with TG measured in 2010 and followed until death, disenrollment or the end of 2016...
July 5, 2018: American Journal of Cardiology
Sofia Skampardoni, Dimitrios Poulikakos, Marek Malik, Darren Green, Philip A Kalra
Cardiovascular mortality is very high in chronic and end-stage kidney disease (ESKD). However, risk stratification data are lacking. Sudden cardiac deaths are among the most common cardiovascular causes of death in these populations. As a result, many studies have assessed the prognostic potential of various electrocardiographic parameters in the renal population. Recent data from studies of implantable loop recordings in haemodialysis patients from five different countries have shed light on a pre-eminent bradyarrhythmic risk of mortality...
August 6, 2018: Nephrology, Dialysis, Transplantation
Olga Lamacchia, Francesca Viazzi, Paola Fioretto, Antonio Mirijello, Carlo Giorda, Antonio Ceriello, Giuseppina Russo, Pietro Guida, Roberto Pontremoli, Salvatore De Cosmo
Background: We described, in a large sample of patients with type 1 diabetes mellitus (T1DM) and GFR ≤ 60 mL/min/1.73 m2 (with or without albuminuria), the differences in the clinical features associated with the two different chronic kidney disease phenotypes and we investigated, in a subset of patients, the modulating role of albuminuria on kidney disease progression. Methods: Clinical data of 1395 patients with T1DM were extracted from electronic medical records...
2018: Diabetology & Metabolic Syndrome
Constantine E Kosmas, Delia Silverio, Christiana Tsomidou, Maria D Salcedo, Peter D Montan, Eliscer Guzman
There is extensive evidence showing that insulin resistance (IR) is associated with chronic low-grade inflammation. Furthermore, IR has been shown to increase the risk for cardiovascular disease (CVD), even in nondiabetic patients, and is currently considered as a "nontraditional" risk factor contributing to CVD by promoting hypertension, oxidative stress, endothelial dysfunction, dyslipidemia, and type 2 diabetes mellitus. However, chronic kidney disease (CKD) is also considered a state of low-grade inflammation...
2018: Clinical Medicine Insights. Endocrinology and Diabetes
Kana Fujikura, Bradley Peltzer, Nidhish Tiwari, Hye Gi Shim, Ally B Dinhofer, Sanyog G Shitole, Jorge R Kizer, Mario J Garcia
BACKGROUND: Patients with chronic kidney disease are at increased risk of cardiovascular disease (CVD). Even after kidney transplant, the rate of CVD events and death remain elevated. Early detection of patients at risk would be helpful for guiding aggressive preventive therapy. The purpose of this study was to evaluate global longitudinal strain (GLS) as a predictor of CVD events and death after kidney transplant. METHOD: Among patients with successful kidney transplant between 3/2009 and 12/2012 at our institution, 111 individuals had an echocardiogram within 6 months of the transplant...
July 22, 2018: International Journal of Cardiology
Anna Jovanovich, Jessica Kendrick
Chronic kidney disease mineral bone disorder (CKD-MBD) is common in end-stage renal disease and is associated with an increased risk of cardiovascular morbidity and mortality. Mainstays of treatment include decreasing serum phosphorus level toward the normal range with dietary interventions and phosphate binders and treating increased parathyroid hormone levels with activated vitamin D and/or calcimimetics. There is significant variation in serum levels of mineral metabolism markers, intestinal absorption of phosphorus, and therapeutic response among individual patients and subgroups of patients with end-stage renal disease...
July 2018: Seminars in Nephrology
Masanari Kuwabara, Remi Kuwabara, Koichiro Niwa, Ichiro Hisatome, Gerard Smits, Carlos A Roncal-Jimenez, Paul S MacLean, Joseph M Yracheta, Minoru Ohno, Miguel A Lanaspa, Richard J Johnson, Diana I Jalal
Obesity is a risk factor for hypertension, diabetes mellitus (DM), dyslipidemia, and hyperuricemia. Here, we evaluated whether the same body mass index (BMI) for the U.S. population conferred similar metabolic risk in Japan. This was a cross-sectional analysis involving 90,047 Japanese adults (18⁻85 years) from St. Luke's International Hospital, Tokyo, Japan and 14,734 adults from National Health and Nutrition Examination Survey (NHANES) collected in the U.S. We compared the prevalence of hypertension, DM, dyslipidemia, and hyperuricemia according to BMI in Japan and the U...
August 3, 2018: Nutrients
Piccoli Giorgina Barbara, Breuer Conrad, Cabiddu Gianfranca, Testa Angelo, Jadeau Christelle, Brunori Giuliano
Nephrology is a complex discipline, including care of kidney disease, dialysis, and transplantation. While in Europe, about 1:10 individuals is affected by chronic kidney disease (CKD), 1:1000 lives thanks to dialysis or transplantation, whose costs are as high as 2% of all the health care budget. Nephrology has important links with surgery, bioethics, cardiovascular and internal medicine, and is, not surprisingly, in a delicate balance between specialization and comprehensiveness, development and consolidation, cost constraints, and competition with internal medicine and other specialties...
August 3, 2018: Journal of Clinical Medicine
Manal Moustafa Mahmoud, Asmaa Shamseldeen, Laila Ahmed Rashed, Amal Elham Fares, Ashraf Shamaa, Doaa Mostafa Gharib
Volume overload, the common phenomenon in patients with chronic kidney disease is associated with cardiovascular risk factors.Howeverits contribution to development of adverse cardiovascular outcomes in those patients is not fully studied.Thus, the presentworkaimed to study the effect of highsalt-induced volumeoverloadin a rat model of chronic kidney disease on cardiac functions and geometry. Thirty adult male Sprague-Dawley rats were randomly divided to a sham operation anduninephrectomy, thenwere subjected to either a normal-salt (0...
August 4, 2018: Canadian Journal of Physiology and Pharmacology
Rafia I Chaudhry, Roy O Mathew, Mandeep S Sidhu, Preety Sidhu-Adler, Radmila Lyubarova, Janani Rangaswami, Loay Salman, Arif Asif, Jerome L Fleg, Peter A McCullough, Frank Maddux, Sripal Bangalore
BACKGROUND: Atherosclerotic cardiovascular disease (ASCVD) is a leading cause of morbidity and mortality among patients with chronic kidney disease (CKD) with a glomerular filtration rate of < 60 mL/min/1.73 m2 body surface area. The availability of high-quality randomized controlled trial data to guide management for the population with CKD and ASCVD is limited. Understanding current practice patterns among providers caring for individuals with CKD and CVD is important in guiding future trial questions...
August 3, 2018: Cardiorenal Medicine
Sandro Ninni, Claire Seunes, Staniel Ortmans, Stéphanie Mouton, Thomas Modine, Mohamed Koussa, Bruno Jegou, Jean-Louis Edme, Bart Staels, David Montaigne, Augustin Coisne
BACKGROUND: A relevant morning-afternoon variation in ischemia-reperfusion (IR) insult after cardiac surgery has been demonstrated. We speculated that the biorhythm might also impact systemic reactions involved in acute kidney injury (AKI) following cardiac surgery. We aimed at investigating incidence, determinants and prognostic impact of AKI in a large cohort of patients referred for surgical aortic valve replacement (SAVR) according to surgery time-of-day. METHODS: Between 2009 and 2015, we explored consecutive patients referred to our Heart Valve Center (CHU Lille) for first SAVR...
July 19, 2018: International Journal of Cardiology
Renata Lopes, Mauro Batista de Morais, Fernanda Luisa Ceragioli Oliveira, Ana Paula Brecheret, Ana Lucia Cardoso Santos Abreu, Maria Cristina de Andrade
OBJECTIVE: To assess the carotid intima-media thickness and factors associated with cardiovascular disease in children and adolescents with chronic kidney disease. MATERIAL AND METHODS: Observational, cross-sectional study carried out at the Universidade Federal de São Paulo (chronic kidney disease outpatient clinics) with 55 patients (60% males) with a median age of 11.9 years (I25-I75: 9.2-14.8 years). Of the 55 patients, 43 were on conservative treatment and 12 were on dialysis...
July 31, 2018: Jornal de Pediatria
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