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Alzheimer's Osa Sleep Apnea

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https://www.readbyqxmd.com/read/30320587/risk-of-alzheimer-s-disease-in-obstructive-sleep-apnea-syndrome-amyloid-%C3%AE-and-tau-imaging
#1
Alby Elias, Tia Cummins, Regan Tyrrell, Fiona Lamb, Vincent Dore, Robert Williams, Jeffrey Rosenfeld, Malcolm Hopwood, Victor L Villemagne, Christopher C Rowe
BACKGROUND: An association between obstructive sleep apnea (OSA) and Alzheimer's disease has been suggested but little is known about amyloid-β and tau deposition in this syndrome. OBJECTIVE: To determine amyloid and tau burden and cognitive function in OSA in comparison to those without a diagnosis of OSA. METHODS: The status of OSA was determined by asking participants about history of polysomnographic diagnosis of OSA and the use of Continuous Positive Airway Pressure (CPAP)...
October 8, 2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29968150/proteomic-biomarkers-of-cognitive-impairment-in-obstructive-sleep-apnea-syndrome
#2
Chitra Lal, Gary Hardiman, Suchit Kumbhare, Charlie Strange
PURPOSE: There are currently no biomarkers that are associated with cognitive impairment (CI) in patients with obstructive sleep apnea syndrome (OSAS). This pilot study performed an exploratory plasma proteomic analysis to discover potential biomarkers and explore proteomic pathways that differentiate OSAS subjects with and without CI. METHODS: Participants were selected from a cohort of women within 5 years of menopause not on hormone replacement therapy between the ages of 45-60 years...
July 2, 2018: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/29782319/the-relationship-between-obstructive-sleep-apnea-and-alzheimer-s-disease
#3
Andreia G Andrade, Omonigho M Bubu, Andrew W Varga, Ricardo S Osorio
Obstructive sleep apnea (OSA) and Alzheimer's disease (AD) are highly prevalent conditions with growing impact on our aging society. While the causes of OSA are now better characterized, the mechanisms underlying AD are still largely unknown, challenging the development of effective treatments. Cognitive impairment, especially affecting attention and executive functions, is a recognized clinical consequence of OSA. A deeper contribution of OSA to AD pathogenesis is now gaining support from several lines of research...
2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29403429/alzheimer-s-disease-mutant-mice-exhibit-reduced-brain-tissue-stiffness-compared-to-wild-type-mice-in-both-normoxia-and-following-intermittent-hypoxia-mimicking-sleep-apnea
#4
Maria José Menal, Ignasi Jorba, Marta Torres, Josep M Montserrat, David Gozal, Anna Colell, Gerard Piñol-Ripoll, Daniel Navajas, Isaac Almendros, Ramon Farré
Background: Evidence from patients and animal models suggests that obstructive sleep apnea (OSA) may increase the risk of Alzheimer's disease (AD) and that AD is associated with reduced brain tissue stiffness. Aim: To investigate whether intermittent hypoxia (IH) alters brain cortex tissue stiffness in AD mutant mice exposed to IH mimicking OSA. Methods: Six-eight month old (B6C3-Tg(APPswe,PSEN1dE9)85Dbo/J) AD mutant mice and wild-type (WT) littermates were subjected to IH (21% O2 40 s to 5% O2 20 s; 6 h/day) or normoxia for 8 weeks...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29125327/obstructive-sleep-apnea-severity-affects-amyloid-burden-in-cognitively-normal-elderly-a-longitudinal-study
#5
Ram A Sharma, Andrew W Varga, Omonigho M Bubu, Elizabeth Pirraglia, Korey Kam, Ankit Parekh, Margaret Wohlleber, Margo D Miller, Andreia Andrade, Clifton Lewis, Samuel Tweardy, Maja Buj, Po L Yau, Reem Sadda, Lisa Mosconi, Yi Li, Tracy Butler, Lidia Glodzik, Els Fieremans, James S Babb, Kaj Blennow, Henrik Zetterberg, Shou E Lu, Sandra G Badia, Sergio Romero, Ivana Rosenzweig, Nadia Gosselin, Girardin Jean-Louis, David M Rapoport, Mony J de Leon, Indu Ayappa, Ricardo S Osorio
RATIONALE: Recent evidence suggests that obstructive sleep apnea (OSA) may be a risk factor for developing mild cognitive impairment and Alzheimer's disease. However, how sleep apnea affects longitudinal risk for Alzheimer's disease is less well understood. OBJECTIVES: To test the hypothesis that there is an association between severity of OSA and longitudinal increase in amyloid burden in cognitively normal elderly. METHODS: Data were derived from a 2-year prospective longitudinal study that sampled community-dwelling healthy cognitively normal elderly...
April 1, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28738188/sleep-characteristics-and-risk-of-dementia-and-alzheimer-s-disease-the-atherosclerosis-risk-in-communities-study
#6
Pamela L Lutsey, Jeffrey R Misialek, Thomas H Mosley, Rebecca F Gottesman, Naresh M Punjabi, Eyal Shahar, Richard MacLehose, Rachel P Ogilvie, David Knopman, Alvaro Alonso
INTRODUCTION: This study tested the hypotheses that late-midlife obstructive sleep apnea (OSA) and short and long sleep duration are associated with dementia over 15 years of follow-up. METHODS: A total of 1667 Atherosclerosis Risk in Communities Study participants underwent in-home polysomnography (1996-1998) and were followed for dementia. Dementia was defined by (1) hospitalization diagnosis codes (1996-2012) and (2) a comprehensive neurocognitive examination (2011-2013) with adjudication...
February 2018: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/28611655/obesity-and-co-morbid-conditions-are-associated-with-specific-neuropsychiatric-symptoms-in-mild-cognitive-impairment
#7
Ashley H Sanderlin, David Todem, Andrea C Bozoki
Background: Neuropsychiatric symptoms (NPSs) in MCI, and midlife obesity increase the likelihood of developing Alzheimer's disease. It is unknown whether obesity or related health conditions modify the risk of NPS or severity of cognitive impairment in MCI. Methods: One hundred and thirteen subjects with MCI were assessed near the time of MCI diagnosis. The sample was divided by BMI and related disorders, type-2 diabetes (T2D) and obstructive sleep apnea (OSA) to measure the relationship of these groups with NPS and severity of MCI...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28550245/amyloid-burden-in-obstructive-sleep-apnea
#8
Chang-Ho Yun, Ho-Young Lee, Seung Ku Lee, Hyun Kim, Hyung Suk Seo, Seong Ae Bang, Sang Eun Kim, Douglas N Greve, Rhoda Au, Chol Shin, Robert J Thomas
To test the hypothesis that excessive amyloid deposition is a biological link between obstructive sleep apnea (OSA) and Alzheimer's disease, we determined whether OSA increases cerebral amyloid burden, relative to controls, using Pittsburgh Compound B (PiB) PET imaging. The subjects were adult participants (age 50-65 years) from the Korean Genome and Epidemiology Study. Polysomnography, brain MRI including 3D images, and a detailed neuro-cognitive function test battery were done in 2011-2012. Nineteen OSA subjects (Apnea-Hypopnea Index [AHI] ≥15/h, 21...
2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28374233/neurological-deficits-in-obstructive-sleep-apnea
#9
REVIEW
Luigi Ferini-Strambi, Giulia Elisabetta Lombardi, Sara Marelli, Andrea Galbiati
Obstructive sleep apnea (OSA) is the most common sleep-related breathing disorder characterized by repetitive episodes of complete or partial obstruction of the upper airway. The prevalence of this disorder is strictly dependent on its gravity. At ≥15 events/h apnea-hypopnea index (AHI), it ranges from 6 to 17% in the general population, with higher rates in men and increasing with age. The hypoxia induced by OSA severely affects the structure and function of blood vessels, culminating in mortality and morbidity...
April 2017: Current Treatment Options in Neurology
https://www.readbyqxmd.com/read/28329084/obstructive-sleep-apnea-is-associated-with-early-but-possibly-modifiable-alzheimer-s-disease-biomarkers-changes
#10
Claudio Liguori, Nicola Biagio Mercuri, Francesca Izzi, Andrea Romigi, Alberto Cordella, Giuseppe Sancesario, Fabio Placidi
Study Objectives: Obstructive sleep apnea (OSA) is a common sleep disorder. The, literature lacks studies examining sleep, cognition, and Alzheimer's Disease (AD) cerebrospinal fluid (CSF) biomarkers in OSA patients. Therefore, we first studied cognitive performances, polysomnographic sleep, and CSF β-amyloid42, tau proteins, and lactate levels in patients affected by subjective cognitive impairment (SCI) divided in three groups: OSA patients (showing an Apnea-Hypopnea Index [AHI] ≥15/hr), controls (showing an AHI < 15/hr), and patients with OSA treated by continuous positive airway pressure (CPAP)...
May 1, 2017: Sleep
https://www.readbyqxmd.com/read/28284842/ageing-and-chronic-intermittent-hypoxia-mimicking-sleep-apnea-do-not-modify-local-brain-tissue-stiffness-in-healthy-mice
#11
Ignasi Jorba, Maria José Menal, Marta Torres, David Gozal, Gerard Piñol-Ripoll, Anna Colell, Josep M Montserrat, Daniel Navajas, Ramon Farré, Isaac Almendros
Recent evidence suggests that obstructive sleep apnea (OSA) may increase the risk of Alzheimer´s disease (AD), with the latter promoting alterations in brain tissue stiffness, a feature of ageing. Here, we assessed the effects of age and intermittent hypoxia (IH) on brain tissue stiffness in a mouse model of OSA. Two-month-old and 18-month-old mice (N=10 each) were subjected to IH (20% O2 40s - 6% O2 20s) for 8 weeks (6h/day). Corresponding control groups for each age were kept under normoxic conditions in room air (RA)...
July 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/27415826/sleep-apnea-sleep-duration-and-brain-mri-markers-of-cerebral-vascular-disease-and-alzheimer-s-disease-the-atherosclerosis-risk-in-communities-study-aric
#12
Pamela L Lutsey, Faye L Norby, Rebecca F Gottesman, Thomas Mosley, Richard F MacLehose, Naresh M Punjabi, Eyal Shahar, Clifford R Jack, Alvaro Alonso
BACKGROUND: A growing body of literature has suggested that obstructive sleep apnea (OSA) and habitual short sleep duration are linked to poor cognitive function. Neuroimaging studies may provide insight into this relation. OBJECTIVE: We tested the hypotheses that OSA and habitual short sleep duration, measured at ages 54-73 years, would be associated with adverse brain morphology at ages 67-89 years. METHODS: Included in this analysis are 312 ARIC study participants who underwent in-home overnight polysomnography in 1996-1998 and brain MRI scans about 15 years later (2012-2013)...
2016: PloS One
https://www.readbyqxmd.com/read/27350397/cerebral-hypoperfusion-and-glucose-hypometabolism-key-pathophysiological-modulators-promote-neurodegeneration-cognitive-impairment-and-alzheimer-s-disease
#13
REVIEW
Mak Adam Daulatzai
Aging, hypertension, diabetes, hypoxia/obstructive sleep apnea (OSA), obesity, vitamin B12/folate deficiency, depression, and traumatic brain injury synergistically promote diverse pathological mechanisms including cerebral hypoperfusion and glucose hypometabolism. These risk factors trigger neuroinflammation and oxidative-nitrosative stress that in turn decrease nitric oxide and enhance endothelin, Amyloid-β deposition, cerebral amyloid angiopathy, and blood-brain barrier disruption. Proinflammatory cytokines, endothelin-1, and oxidative-nitrosative stress trigger several pathological feedforward and feedback loops...
April 2017: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/27322475/changes-in-neurocognitive-architecture-in-patients-with-obstructive-sleep-apnea-treated-with-continuous-positive-airway-pressure
#14
Ivana Rosenzweig, Martin Glasser, William R Crum, Matthew J Kempton, Milan Milosevic, Alison McMillan, Guy D Leschziner, Veena Kumari, Peter Goadsby, Anita K Simonds, Steve C R Williams, Mary J Morrell
BACKGROUND: Obstructive sleep apnea (OSA) is a chronic, multisystem disorder that has a bidirectional relationship with several major neurological disorders, including Alzheimer's dementia. Treatment with Continuous Positive Airway Pressure (CPAP) offers some protection from the effects of OSA, although it is still unclear which populations should be targeted, for how long, and what the effects of treatment are on different organ systems. We investigated whether cognitive improvements can be achieved as early as one month into CPAP treatment in patients with OSA...
May 2016: EBioMedicine
https://www.readbyqxmd.com/read/27189468/obstructive-sleep-apnea-syndrome-an-emerging-risk-factor-for-dementia
#15
Laura Buratti, Simona Luzzi, Cristina Petrelli, Sara Baldinelli, Giovanna Viticchi, Leandro Provinciali, Claudia Altamura, Fabrizio Vernieri, Mauro Silvestrini
Epidemiological studies have suggested that obstructive sleep apnea syndrome (OSAS) may increase the risk of developing cognitive impairment. In patients with Alzheimer's disease (AD), the prevalence of OSAS is much higher than that expected in cognitively healthy subjects. A deeper knowledge of the pathophysiological link between OSAS and AD and the demonstration that OSAS may directly influence the development of cognitive alterations, would increase prevention and treatment strategies for AD patients. In this article, we discuss the evidence of the association between OSAS and dementia...
2016: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/27148046/the-association-between-obstructive-sleep-apnea-and-alzheimer-s-disease-a-meta-analysis-perspective
#16
Farnoosh Emamian, Habibolah Khazaie, Masoud Tahmasian, Guy D Leschziner, Mary J Morrell, Ging-Yuek R Hsiung, Ivana Rosenzweig, Amir A Sepehry
Alzheimer's disease (AD) and obstructive sleep apnea (OSA) are highly prevalent, chronic conditions with intriguing, yet poorly understood epidemiological overlap. To date, the amount of OSA syndrome present in patients with AD across literature remains unknown. To address this question, we collected all available published clinical data and analyzed them through a quantitative meta-analytical approach. The results of our quantitative meta-analysis suggest that the aggregate odds ratio for OSA in AD vs. healthy control was 5...
2016: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/27129429/obstructive-sleep-apnea-decreases-central-nervous-system-derived-proteins-in-the-cerebrospinal-fluid
#17
Yo-El S Ju, Mary Beth Finn, Courtney L Sutphen, Elizabeth M Herries, Gina M Jerome, Jack H Ladenson, Daniel L Crimmins, Anne M Fagan, David M Holtzman
We hypothesized that one mechanism underlying the association between obstructive sleep apnea (OSA) and Alzheimer's disease is OSA leading to decreased slow wave activity (SWA), increased synaptic activity, decreased glymphatic clearance, and increased amyloid-β. Polysomnography and lumbar puncture were performed in OSA and control groups. SWA negatively correlated with cerebrospinal fluid (CSF) amyloid-β-40 among controls and was decreased in the OSA group. Unexpectedly, amyloid-β-40 was decreased in the OSA group...
July 2016: Annals of Neurology
https://www.readbyqxmd.com/read/27070140/biomarkers-of-alzheimer-disease-in-children-with-obstructive-sleep-apnea-effect-of-adenotonsillectomy
#18
Leila Kheirandish-Gozal, Mona F Philby, María Luz Alonso-Álvarez, Joaquin Terán-Santos, David Gozal
STUDY OBJECTIVE: Obese children are at increased risk for developing obstructive sleep apnea (OSA), and both of these conditions are associated with an increased risk for end-organ morbidities. Both OSA and obesity (OB) have been associated with increased risk for Alzheimer disease (AD). This study aimed to assess whether OSA and OB lead to increased plasma levels of 2 AD markers amyloid β protein 42 (Aβ42) and pre-senilin 1 (PS1). METHODS: Fasting morning plasma samples from otherwise healthy children with a diagnosis of OB, OSA, or both (OSA+OB), and controls, and in a subset of children with OSA after adenotonsillectomy (T&A) were assayed for Aβ42 and PS1 levels using commercial enzyme-linked immunosorbent assay kits...
June 1, 2016: Sleep
https://www.readbyqxmd.com/read/26351108/serum-amyloid-beta-levels-are-increased-in-patients-with-obstructive-sleep-apnea-syndrome
#19
Xian-Le Bu, Yu-Hui Liu, Qing-Hua Wang, Shu-Sheng Jiao, Fan Zeng, Xiu-Qing Yao, Dong Gao, Ji-Chuan Chen, Yan-Jiang Wang
A critical link between amyloid-beta (Aβ) and hypoxia has been demonstrated in in vitro and animal studies but has not yet been proven in humans. Obstructive sleep apnea syndrome (OSAS) is a common disorder that is characterized by nocturnal intermittent hypoxaemia. This study sought to examine the association between the chronic intermittent hypoxia and Aβ in OSAS patients. Forty-five cognitively normal OSAS patients and forty-nine age- and gender-matched subjects diagnosed with simple snoring and not OSAS were included in the present study...
September 9, 2015: Scientific Reports
https://www.readbyqxmd.com/read/26309091/14th-annual-meeting-of-the-safety-pharmacology-society-threading-through-peripheral-and-central-nervous-system-presentations
#20
Icilio Cavero, Henry Holzgrefe
The 2014 Annual Meeting of the Safety Pharmacology Society discussed pathophysiological mechanisms and novel investigational approaches to assess drug safety. The plenary keynote reviewed past, present, and future research on Alzheimer's disease. Polysomnography tools can uncover drug-induced sleep disturbances. FDA examiners currently assess proconvulsive liabilities on a case-by-case basis due to the lack of official guidance. In contrast, abuse liability potential is determined according to established paradigms...
September 2015: Journal of Pharmacological and Toxicological Methods
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