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Catalina Salgado-Salazar, Nina Shiskoff, Margery Daughtrey, Cristi L Palmer, Jo Anne Crouch
Peronospora sparsa is a downy mildew-causing oomycete that can infect roses, blackberries, and other members of the rose family. During the last 70 years, this disease has become a serious problem for rose growers in the U.S. and worldwide. While much is known about the disease and its treatment, including significant research on molecular identification methods, as well as environmental conditions conducive to disease and the fungicides used to prevent it, significant knowledge gaps remain in our basic comprehension of the pathogen's biology...
August 15, 2018: Plant Disease
Sebastian Nowak, Alois M Sprinkart
This work presents an approach for synchronization and alignment of Digital Imaging and Communications in Medicine (DICOM) series from different studies that allows, e.g., easier reading of follow-up examinations. The proposed concept developed within the DICOM's patient-based reference coordinate system allows to synchronize all image data of two different studies/examinations based on a single registration. The most suitable DICOM series for registration could be set as default per protocol. Necessary basics regarding the DICOM standard and the used mathematical transformations are presented in an educative way to allow straightforward implementation in Picture Archiving And Communications Systems (PACS) and other DICOM tools...
August 14, 2018: Journal of Digital Imaging: the Official Journal of the Society for Computer Applications in Radiology
Xinhua Zhu, Ke Liu, Jialin Wang, Haisen Peng, Qibin Pan, Shuhong Wu, Yinli Jiang, Yuehui Liu
The present study aimed to investigate the effects of C‑C chemokine receptor type 3 (CCR3) gene knockout on allergic rhinitis (AR) in mice, as well as the underlying molecular mechanisms. Ovalbumin was administrated to CCR3+/+ and CCR3‑/‑ BALB/c mice to establish an AR model. The mice were divided into four groups: i) Normal control (CG), ii) AR model (AR), iii) CCR3 knockout CG (CCR3‑/‑CG) and iv) AR model with CCR3 knockout (CCR3‑/‑AR). Histological sections of nasal mucosae were examined by hematoxylin and eosin staining, which revealed that CCR3 knockout suppressed the invasion of inflammatory cells and relieved the damage of nasal mucosae...
August 10, 2018: Molecular Medicine Reports
Laurens Doucet, Ruben Lammens, Sarah Hendrickx, Phillipe Dewolf
BACKGROUND: The importance of early cardiopulmonary resuscitation (CPR) during an out-of-hospital cardiac arrest (OHCA) cannot be emphasized enough and has a major impact on survival. Unfortunately, CPR education in schools is often inadequate or non-existing due to lack of educators and financial resources. The introduction of application-based teaching could facilitate education as no instructor is needed. The aim of present study is to compare app-based self-teaching (intervention group) with a traditional instructor-led course (control group)...
August 14, 2018: Acta Clinica Belgica
Oren Avram, Anna Vaisman-Mentesh, Dror Yehezkel, Haim Ashkenazy, Tal Pupko, Yariv Wine
Reproducible and robust data on antibody repertoires are invaluable for basic and applied immunology. Next-generation sequencing (NGS) of antibody variable regions has emerged as a powerful tool in systems immunology, providing quantitative molecular information on antibody polyclonal composition. However, major computational challenges exist when analyzing antibody sequences, from error handling to hypermutation profiles and clonal expansion analyses. In this work, we developed the ASAP (A webserver for Immunoglobulin-Seq Analysis Pipeline) webserver (https://asap...
2018: Frontiers in Immunology
Kristina Sivertsen, Marko Lukic, Agnete E Kristoffersen
BACKGROUND: Alcohol is consumed almost worldwide and is the most widely used recreational drug in the world. Harmful use of alcohol is known to cause a large disease-, social- and economic burden on society. Only a few studies have examined the relationship between CAM use and alcohol consumption. To our knowledge there has been no such research in Norway. The aim of this study is to describe and compare alcohol consumption and injuries related to alcohol across gender and different CAM approaches...
August 13, 2018: BMC Complementary and Alternative Medicine
Wuxia Bi, Baisha Weng, Zhe Yuan, Mao Ye, Cheng Zhang, Yu Zhao, Dengming Yan, Ting Xu
It is of great significance to study the effects and mechanisms of the key driving forces of surface water quality deterioration-climate change and LUCC (land use and land cover change). The Luanhe River Basin (LRB) in north-eastern China was examined for qualitatively and quantitatively assessing the responses of total nitrogen (TN) and total phosphorus (TP) loads on different climate scenarios and LUCC scenarios. The results show that from 1963 to 2017, the TN and TP loads basically presented a negative correlation with the temperature change (except for winter), while showing a significant positive correlation with the precipitation change...
August 11, 2018: International Journal of Environmental Research and Public Health
Yong Xu, Huabin Sun, Ao Liu, Hui-Hui Zhu, Wenwu Li, Yen-Fu Lin, Yong-Young Noh
Organic field-effect transistors (OFETs) are the central building blocks of organic electronics, but still suffer from low performance and manufacturing difficulties. This is due in part to the absence of doping, which is mostly excluded from OFET applications for the concern about uncontrollable dopant diffusion. Doping enabled the modern semiconductor industry to build essential components like Ohmic contacts and P-N junctions, empowering devices to function as designed. Recent breakthroughs in organic semiconductors and doping techniques demonstrated that doping can also be a key enabler for high-performance OFETs...
August 13, 2018: Advanced Materials
Madhurendra Singh, Laura Bergmann, Alexander Lang, Katja Pexa, Fabian Kuck, Dennis Stibane, Linda Janke, Hakima Ezzahoini, Antje Lindecke, Constanze Wiek, Helmut Hanenberg, Karl Köhrer, Charlotte von Gall, Hans Reinke, Roland P Piekorz
The albumin D-box binding protein (DBP) is a member of the PAR bZip (proline and acidic amino acid-rich basic leucine zipper) transcription factor family and functions as important regulator of circadian core and output gene expression. Gene expression of DBP itself is under the control of E-box-dependent binding by the Bmal1-Clock heterodimer and CRE-dependent binding by the cAMP responsive element binding protein (CREB). However, the signaling mechanism mediating CREB-dependent regulation of DBP expression in the peripheral clock remains elusive...
July 13, 2018: Oncotarget
Margarita L Zuley, Robert M Nishikawa, Cindy S Lee, Elizabeth Burnside, Robert Rosenberg, Edward A Sickles, Wendie Berg, Jessica Leung, Jennifer Harvey, Debapriya Sengupta, David Gur
PURPOSE: The National Mammography Database (NMD) contains nearly 20 million examinations from 693 facilities; it is the largest information source for use and effectiveness of breast imaging in the United States. NMD collects demographic, imaging, interpretation, biopsy, and basic pathology results, enabling facility and physician comparison for quality improvement. However, NMD lacks treatment and clinical outcomes data. The network of state cancer registries (CRs) contains detailed pathologic, treatment, and clinical outcomes data...
August 8, 2018: Journal of the American College of Radiology: JACR
Ashley E Cole, Fatmah M Hani, Brian W Allen, Paul C Kline, Elliot Altman
The isolation and characterization of 42 unique nonfunctional missense mutants in the bacterial cytosolic β-galactosidase and catechol 2,3-dioxygenase enzymes allowed us to examine some of the basic general trends regarding protein structure and function. A total of 6 out of the 42, or 14.29% of the missense mutants were in α-helices, 17 out of the 42, or 40.48%, of the missense mutants were in β-sheets and 19 out of the 42, or 45.24% of the missense mutants were in unstructured coil, turn or loop regions...
August 10, 2018: Protein Journal
John Synovec, Leah Plumblee, William Barfield, Harris Slone
OBJECTIVE: Previously published studies have evaluated Orthopedic In-Training Examination sports medicine questions, but none have evaluated whether question difficulty has changed over time. DESIGN: Sports medicine subsection questions between 2012 and 2016 were evaluated and compared with previously published data on Orthopedic In-Training Examination from 2004 to 2009. Question categories were classified into 1 of 3 taxonomy levels-basic recall, diagnosis, and advanced problem solving...
August 8, 2018: Journal of Surgical Education
Ewelina M Swierad, Terry T K Huang
Urban green space has been positively associated with psychological and physical health. However, the linkage between exposure to parks and health outcomes remains unclear. The current study examined the meanings that people assign to city parks, as a way to understand the pathways by which parks exert their effects on health. We conducted qualitative interviews with twenty culturally diverse residents in New York City. Thematic analysis was performed on the qualitative data. Results showed that all themes identified were related to parks fulfilling a basic human need for connection to (1) family, loved ones, and friends; (2) community and neighborhood; (3) self; and (4) nature...
August 8, 2018: International Journal of Environmental Research and Public Health
Lingzhi Ni, Keke Li, Longfei Jiang, Jie Chen, Yanyan Chen, Xiaoman Li, Na Lin, Frank Thorn, Ruzhi Deng
PURPOSE: The purposes of the study were to analyze patient use and satisfaction with low vision aids (LVAs) at the Wenzhou Medical University Low Vision and Rehabilitation Center and to assess the promotion of visual rehabilitation services as a new responsibility for nurses in China. METHODS: Records of 178 patients with low vision (LV) from the Low Vision and Rehabilitation Center examined between October 2015 and October 2016 included basic patient information (e...
August 8, 2018: Rehabilitation Nursing: the Official Journal of the Association of Rehabilitation Nurses
Aisha A AlJanahi, Mark Danielsen, Cynthia E Dunbar
The recent development of single-cell RNA sequencing has deepened our understanding of the cell as a functional unit, providing new insights based on gene expression profiles of hundreds to hundreds of thousands of individual cells, and revealing new populations of cells with distinct gene expression profiles previously hidden within analyses of gene expression performed on bulk cell populations. However, appropriate analysis and utilization of the massive amounts of data generated from single-cell RNA sequencing experiments are challenging and require an understanding of the experimental and computational pathways taken between preparation of input cells and output of interpretable data...
September 21, 2018: Molecular Therapy. Methods & Clinical Development
William V Massey, Megan B Stellino, Margaret Fraser
The purpose of this study was to examine individual variables associated with children's levels of recess physical activity (PA), as well as environmental influences that influence children's engagement during recess. Participants ( n  = 146) were 4-6th grade students across seven schools. PA data were collected using the Fitbit Flex. Psychological need satisfaction at recess data were collected with a basic psychological need satisfaction for recess PA survey. Observations of recess activity engagement and the quality of the recess environment were also collected at 134 recess periods ( n  = 8340 children) across nine schools...
September 2018: Preventive Medicine Reports
Wei Liu, Yanan Wu, Lingling Bai, Jingxian Ni, Jun Tu, Jie Liu, Quanjun Deng, Xianjia Ning, Jinghua Wang
BACKGROUND: At the global level, dementia is the leading cause of dependence and disability among the elderly. Although the preponderant prevalence in women has been identified, the sex differences in risk factors were unclear. We aimed to evaluate the sex differences in the prevalence of nonvascular cognitive impairment and the risk factors among the elderly in rural China screened with the Mini-Mental State Examination (MMSE). METHODS: Between 2014 and 2015, a population-based cross-section study was conducted to collect basic information among the elderly aged 60 years and over...
August 9, 2018: Neuroepidemiology
Dina Tucovic, Aleksandra Popov Aleksandrov, Ivana Mirkov, Marina Ninkov, Jelena Kulas, Lidija Zolotarevski, Vesna Vukojevic, Jelena Mutic, Nikola Tatalovic, Milena Kataranovski
Skin can acquire cadmium (Cd) by oral route, but there is paucity of data concerning cutaneous effects of this metal. Cd acquired by oral route can affect skin wound healing, but the effect of Cd on other activities involved in skin homeostasis, including skin immunity, are not explored. Using the rat model of 30-day oral administration of Cd (5 ppm and 50 ppm) in drinking water, basic aspects of immune-relevant activity of epidermal cells were examined. Dose-dependent Cd deposition in the the skin was observed (0...
August 6, 2018: Ecotoxicology and Environmental Safety
Bigyan Mainali, Matthew B Schabath, Staci L Sudenga, Cynthia Ye, Howard W Wiener, Luisa L Villa, Anna R Giuliano, Sadeep Shrestha
OBJECTIVES: While most human papillomavirus (HPV) infection clears on its own, persistent HPV infection can cause genital warts and anal, penile and oropharyngeal cancers in men. We conducted genetic analysis in a sub-cohort of the HPV infection in men (HIM) study to test the hypothesis that differences in host genes influence HPV persistence in men. METHODS: Baseline and longitudinal genital HPV status at the genitals was measured every 6-months using the Linear Array assay amplified HPV L1 gene fragment using the PGMY09/11 L1 consensus primer system...
August 6, 2018: Papillomavirus Research
Tereza Kubíková, Martin Bartoš, Štefan Juhas, Tomáš Suchý, Pavla Sauerová, Marie Hubálek-Kalbáčová, Zbyněk Tonar
The aim of this study was to compare data on the volume fraction of bone and the thickness of the cortical compact bone acquired during microcomputed tomography (micro-CT) analysis with data acquired from identical samples using stereological analysis of either decalcified paraffin sections or ground sections. Additionally, we aimed to compare adjacent tissue samples taken from the major trochanter of the porcine femur to map the basic biological variability of trabecular bone. Fifteen pairs of adjacent tissue blocks were removed from the major trochanter of the proximal epiphyses of porcine femurs (female pigs aged 24-39 months, weight=59...
August 6, 2018: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
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