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https://www.readbyqxmd.com/read/30335071/-the-dynamics-of-erythrocytes-functional-indicators-in-patients-with-charcot-marie-toota-disease-during-cytoprotective-therapy
#1
A V Deryugina, E A Antipenko
AIM: To study an impact of cytoflavin on the functional state of erythrocytes in patients with Charcot - Marie - Toota disease (CMTD). MATERIAL AND METHODS: Thirty patients with CMTD were examined. The main group (n=17) received cytoflavin along with basic therapy (intravenously dropwise 10 ml per 200 ml of 5% glucose solution for 10 days). The comparison group (n=13) received only basic therapy. Functional parameters of erythrocytes, including electrophoretic mobility of erythrocytes (EFME), concentration of malonic dialdehyde (MDA), content of ATP and 2...
2018: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/30335070/-dose-dependent-effects-of-cortexin-in-chronic-cerebral-ischemia-results-of-a-multicenter-randomized-controlled-study
#2
A I Fedin, G N Belskaya, O V Kurushina, V V Kovalchuk, E V Starych, L V Chichanovskaya, O A Baranova
AIM: To study an effect of cortexin on neurological symptoms and oxidative stress as part of the ischemic cascade in chronic cerebral ischemia (CCI), I-II stages. MATERIAL AND METHODS: The multicenter randomized controlled study included 189 patients with CCI, 42 (22.2%) men and 147 (77.8%) women, mean age 64.3±0.5 years. Patients were randomized into three groups. Group 1 received intramuscular injection of 20 mg of cortexin, group 2 received 10 mg of cortexin; group 3 received basic treatment only...
2018: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/30334497/ethics-in-humanitarian-efforts-when-should-resources-be-allocated-to-paediatric-heart-surgery
#3
Kathleen N Fenton, Marcelo Cardarelli, Frank Molloy, William M Novick
BACKGROUND: In countries with ample resources, no debate exists as to whether heart surgery should be provided. However, where funding is limited, what responsibility exists to care for children with congenital heart defects? If children have a "right" to surgical treatment, to whom is the "duty" to provide it assigned? These questions are subjected to ethical analysis. METHODS: Examination is initially based on the four principles of medical ethics: autonomy, beneficence, non-maleficence, and justice...
October 18, 2018: Cardiology in the Young
https://www.readbyqxmd.com/read/30333973/cellular-and-molecular-networking-within-the-ecosystem-of-cancer-cell-communication-via-tunneling-nanotubes
#4
Emil Lou, Edward Zhai, Akshat Sarkari, Snider Desir, Phillip Wong, Yoshie Iizuka, Jianbo Yang, Subbaya Subramanian, James McCarthy, Martina Bazzaro, Clifford J Steer
Intercellular communication is vital to the ecosystem of cancer cell organization and invasion. Identification of key cellular cargo and their varied modes of transport are important considerations in understanding the basic mechanisms of cancer cell growth. Gap junctions, exosomes, and apoptotic bodies play key roles as physical modalities in mediating intercellular transport. Tunneling nanotubes (TNTs)-narrow actin-based cytoplasmic extensions-are unique structures that facilitate direct, long distance cell-to-cell transport of cargo, including microRNAs, mitochondria, and a variety of other sub cellular components...
2018: Frontiers in Cell and Developmental Biology
https://www.readbyqxmd.com/read/30332758/running-as-a-form-of-therapy-socio-psychological-functions-of-mass-running-events-for-men-and-women
#5
Ewa Malchrowicz-Mośko, Joanna Poczta
The main goal of this study was to recognize the motives of participation in mass running events (Poznan Half Marathon case study). The second aim was to examine the motivations to participate in a half-marathon among two groups of respondents: men and women, and to evaluate the differences between them. The empirical research among runners ( n = 560) conducted during the one of the most important running events in Poland recognized the motives for participation in the sports event in accordance with the four basic types of orientation: social orientation, experience orientation, factual orientation, and result orientation (Freyer & Gross, 2002)...
October 16, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/30332659/clinical-and-electrographic-characteristics-of-seizures-in-lgi1-antibody-encephalitis
#6
Li-Hao Li, Cong-Cong Ma, Hai-Feng Zhang, Ya-Jun Lian
PURPOSE: The purpose of this study was to analyze the clinical and electrographic characteristics of seizures in LGI1-antibody encephalitis. METHODS: The methods utilized in this study were prospective analysis of the clinical manifestations, types of seizures, electroencephalogram (EEG), adjuvant examination, treatment and prognosis of 19 cases of LGI1-antibody encephalitis diagnosed from January 2017 to February 2018 in First Affiliated Hospital of Zhengzhou University, and reviewed related literatures...
October 14, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/30332613/the-lifespan-human-connectome-project-in-aging-an-overview
#7
Susan Y Bookheimer, David H Salat, Melissa Terpstra, Beau M Ances, Deanna M Barch, Randy L Buckner, Gregory C Burgess, Sandra W Curtiss, Mirella Diaz-Santos, Jennifer Stine Elam, Bruce Fischl, Douglas N Greve, Hannah A Hagy, Michael P Harms, Olivia M Hatch, Trey Hedden, Cynthia Hodge, Kevin C Japardi, Taylor P Kuhn, Timothy K Ly, Stephen M Smith, Leah H Somerville, Kâmil Uğurbil, Andre van der Kouwe, David Van Essen, Roger P Woods, Essa Yacoub
The original Human Connectome Project yielded a rich data set on structural and functional connectivity in a large sample of healthy young adults using improved methods of data acquisition, analysis, and sharing. More recent efforts are extending this approach to include infants, children, older adults, and brain disorders. This paper introduces and describes the Human Connectome Project in Aging (HCP-A), which is currently recruiting 1200 + healthy adults aged 36 to 100+, with a subset of 600 + participants returning for longitudinal assessment...
October 14, 2018: NeuroImage
https://www.readbyqxmd.com/read/30332315/apol1-polymorphisms-and-kidney-disease-loss-of-function-or-gain-of-function
#8
Leslie A Bruggeman, John Francis O'Toole, John Sedor
The mechanism that explains the association of APOL1 variants with non-diabetic kidney diseases in African Americans remains unclear. Kidney disease risk is inherited as a recessive trait and many studies investigating the intracellular function of APOL1 have indicated the APOL1 variants G1 and G2 are associated with cytotoxicity. Whether cytotoxicity results from the absence of a protective effect conferred by the G0 allele or induced by a deleterious effect of variant allele expression has not be conclusively established...
October 17, 2018: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/30332290/peering-into-the-black-box-of-artificial-intelligence-evaluation-metrics-of-machine-learning-methods
#9
Guy S Handelma, Hong Kuan Kok, Ronil V Chandra, Amir H Razavi, Shiwei Huang, Mark Brooks, Michael J Lee, Hamed Asadi
OBJECTIVE: Machine learning (ML) and artificial intelligence (AI) are rapidly becoming the most talked about and controversial topics in radiology and medicine. Over the past few years, the numbers of ML- or AI-focused studies in the literature have increased almost exponentially, and ML has become a hot topic at academic and industry conferences. However, despite the increased awareness of ML as a tool, many medical professionals have a poor understanding of how ML works and how to critically appraise studies and tools that are presented to us...
October 17, 2018: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/30328405/a-standardized-low-cost-peer-role-playing-training-intervention-improves-medical-student-competency-in-communicating-bad-news-to-patients-in-botswana
#10
Katherine D Westmoreland, Francis M Banda, Andrew P Steenhoff, Elizabeth D Lowenthal, Erik Isaksson, Bernhard A Fassl
OBJECTIVE: The purpose of this study was to demonstrate effectiveness of an educational training workshop using role-playing to teach medical students in Botswana to deliver bad news. METHOD: A 3-hour small group workshop for University of Botswana medical students rotating at the Princess Marina Hospital in Gaborone was developed. The curriculum included an overview of communication basics and introduction of the validated (SPIKES) protocol for breaking bad news...
October 17, 2018: Palliative & Supportive Care
https://www.readbyqxmd.com/read/30327632/somatosensory-stimulus-intensity-encoding-in-borderline-personality-disorder
#11
Kathrin Malejko, Dominik Neff, Rebecca C Brown, Paul L Plener, Martina Bonenberger, Birgit Abler, Georg Grön, Heiko Graf
Borderline Personality Disorder (BPD) is clinically characterized by emotional instability, interpersonal disturbances and dysfunctional behavior such as non-suicidal self-injury (NSSI). During NSSI, patients with BPD typically report analgesic or hypoalgesic phenomena, and pain perception and pain processing in BPD have been repeatedly investigated. Most of the studies so far focused on affective-motivational and cognitive-evaluative neural components of pain within categorial study designs. By contrast, rather basic somatosensory aspects such as neural intensity-encoding of somatosensory stimuli were not examined in further details...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/30327615/physiological-responses-to-swimming-induced-exercise-in-the-adult-zebrafish-regenerating-heart
#12
Mireia Rovira, Daniel M Borràs, Inês J Marques, Carolina Puig, Josep V Planas
Exercise promotes a set of physiological responses known to provide long-term health benefits and it can play an important role in cardioprotection. In the present study, we examined cardiac responses to exercise training in the adult zebrafish and in the context of cardiac regeneration. We found that swimming-induced exercise increased cardiomyocyte proliferation and that this response was also found under regenerating conditions, when exercise was performed either prior to and after ventricular cryoinjury (CI)...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/30327589/cell-specific-transcriptome-analysis-shows-that-adult-pillar-and-deiters-cells-express-genes-encoding-machinery-for-specializations-of-cochlear-hair-cells
#13
Huizhan Liu, Lei Chen, Kimberlee P Giffen, Sean T Stringham, Yi Li, Paul D Judge, Kirk W Beisel, David Z Z He
The mammalian auditory sensory epithelium, the organ of Corti, is composed of hair cells and supporting cells. Hair cells contain specializations in the apical, basolateral and synaptic membranes. These specializations mediate mechanotransduction, electrical and mechanical activities and synaptic transmission. Supporting cells maintain homeostasis of the ionic and chemical environment of the cochlea and contribute to the stiffness of the cochlear partition. While spontaneous proliferation and transdifferentiation of supporting cells are the source of the regenerative response to replace lost hair cells in lower vertebrates, supporting cells in adult mammals no longer retain that capability...
2018: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/30326985/acquiring-a-first-language-in-adolescence-the-case-of-basic-word-order-in-american-sign-language
#14
Qi Cheng, Rachel I Mayberry
Previous studies suggest that age of acquisition affects the outcomes of learning, especially at the morphosyntactic level. Unknown is how syntactic development is affected by increased cognitive maturity and delayed language onset. The current paper studied the early syntactic development of adolescent first language learners by examining word order patterns in American Sign Language (ASL). ASL uses a basic Subject-Verb-Object order, but also employs multiple word order variations. Child learners produce variable word order at the initial stage of acquisition, but later primarily produce canonical word order...
October 17, 2018: Journal of Child Language
https://www.readbyqxmd.com/read/30326540/-perimetry-in-neuro-ophthalmological-function-diagnostics-indication-methods-topodiagnostic-aspects
#15
Judith Ungewiss, Ulrich Schiefer
The assessment of visual field findings is fundamental in neuro-ophthalmological functional diagnostics: By means of perimetry, functional and topodiagnostic considerations in case of unexplained visual loss or suspected lesions of the visual pathway are possible in a non-invasive manner. Repeated examinations allow for functional follow-up of a disease and judgement on the efficacy of a therapeutic procedure. This paper is intended to convey the basics of visual field examination and diagnostics. The focus is on the value of perimetry in neuro-ophthalmological functional diagnostics...
October 16, 2018: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/30325869/metabolic-evaluation-who-when-and-how-often
#16
Vincent De Coninck, Etienne Xavier Keller, Olivier Traxer
PURPOSE OF REVIEW: To summarize recommendations of the guidelines of the American Urological Association and European Association of Urology, and our opinion on which urinary tract stone disease patients should be metabolically evaluated at which moment and how often. RECENT FINDINGS: A standard metabolic evaluation should be performed in all stone formers to prevent recurrent disease. This includes a medical and lifestyle history, physical examination, basic urine and blood analysis, radiological examination and stone analysis...
October 15, 2018: Current Opinion in Urology
https://www.readbyqxmd.com/read/30325269/adsorption-kinetics-and-modelling-of-h-2-s-by-treated-waste-oil-fly-ash
#17
Zaheer Aslam, Ibnelwaleed A Hussein, Reyad A Shawabkeh, Mohammad Anwar Parvez, Waqar Ahmad, Ihsanullah
Waste oil fly ash (OFA) collected from disposal of power generation plants was treated by physico-chemical activation technique to improve the surface properties of OFA. This synthesized material was further used for potential H2 S adsorption from synthetic natural gas. The raw OFA was basically modified with the mixture of acids (20% HNO3 and 80% H3 PO4 ) and it was further treated with 2M KOH to enhance the surface affinity as well as surface area of synthesized activated carbon. Correspondingly, it enhanced the adsorption of H2 S...
October 16, 2018: Journal of the Air & Waste Management Association
https://www.readbyqxmd.com/read/30324694/structural-and-quantitative-changes-of-saponins-in-fresh-alfalfa-compared-to-alfalfa-silage
#18
Malgorzata Szumacher-Strabel, Anna Stochmal, Adam Cieslak, Martyna Kozłowska, Dawid Kuznicki, Mariusz Kowalczyk, Wieslaw Oleszek
BACKGROUND: Alfalfa (Medicago sativa) is an important legume used in animal feed. The primary objective in this study was to analyze and trace the individual saponins in fresh and ensiled alfalfa of ten varieties, with the aim of evaluating the structural changes undergone by saponins during ensiling. A secondary objective was to examine whether any of the changes in saponin content were associated with changes in the basic nutrient composition of the ensiled alfalfa. RESULTS: The total saponin concentration increased when the fresh alfalfa was processed into silage...
October 16, 2018: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/30323703/modeling-integration-co-teaching-basic-and-clinical-sciences-medicine-in-the-classroom
#19
Joanne M Willey, Youn Seon Lim, Thomas Kwiatkowski
Purpose: Calls for revision in undergraduate medical education frequently cite the importance of integrating basic and clinical sciences and the use of active pedagogies. One under-appreciated approach to accomplishing both is interactive co-teaching, defined as two instructors with complementary expertise engaging students and each other instead of lecturing. This study sought to determine if interactive co-teaching helped students integrate and learn basic and clinical sciences, as well as to explore potential advantages and barriers to co-teaching...
2018: Advances in Medical Education and Practice
https://www.readbyqxmd.com/read/30322694/training-surgical-residents-for-ultrasound-guided-assessment-and-management-of-unstable-patients
#20
Faraz Mahmood, Jeffrey Bortman, Rabia Amir, John Mitchell, Vanessa Wong, Ruby Feng, Zhifeng Gao, Yannis Amador, Mario Montealegre-Gallegos, Tara Kent, Robina Matyal
OBJECTIVE: Proficiency in the use of ultrasound is presently not an ACGME required core competency for accredited surgical training. There should be a basic unified ultrasound curriculum for surgical trainees. We developed a multimodal ultrasound-training program to ensure baseline proficiency and readiness for clinical performance without impacting trainee duty hours. DESIGN: We developed and implemented a multimodal curriculum for ultrasound education and its use as a supplement to clinical evaluation of unstable patients...
October 12, 2018: Journal of Surgical Education
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