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JOURNAL ARTICLE
Community considerations for aggressive intensive care therapy for infants <24+0 weeks of gestation.
Úrsula Guillén, John A F Zupancic, Jonathan S Litt, Joseph Kaempf, Avroy Fanaroff, Richard A Polin, Richard Martin, Eric Eichenwald, Deanne Wilson-Costello, A David Edwards, Mikko Hallman, Christoph Bührer, Jonathan Fanaroff, Susan Albersheim, Nicholas D Embleton, Prakesh S Shah, Phyllis A Dennery, Deborah Discenza, Alan H Jobe, Haresh Kirpalani
No abstract text is available yet for this article.
February 7, 2024: Journal of Pediatrics
#2
JOURNAL ARTICLE
Petek Eylul Taneri, Jamie J Kirkham, Eleanor J Molloy, Linda Biesty, Richard A Polin, James L Wynn, Barbara J Stoll, Niranjan Kissoon, Kondwani Kawaza, Mandy Daly, Aoife Branagan, Lívia Nagy Bonnard, Eric Giannoni, Tobias Strunk, Magdalena Ohaja, Kenneth Mugabe, Denise Suguitani, Fiona Quirke, Declan Devane
Neonatal sepsis is a serious public health problem; however, there is substantial heterogeneity in the outcomes measured and reported in research evaluating the effectiveness of the treatments. Therefore, we aim to develop a Core Outcome Set (COS) for studies evaluating the effectiveness of treatments for neonatal sepsis. Since a systematic review of key outcomes from randomised trials of therapeutic interventions in neonatal sepsis was published recently, we will complement this with a qualitative systematic review of the key outcomes of neonatal sepsis identified by parents, other family members, parent representatives, healthcare providers, policymakers, and researchers...
2023: PloS One
#3
Russell A Poldrack, Christopher J Markiewicz, Stefan Appelhoff, Yoni K Ashar, Tibor Auer, Sylvain Baillet, Shashank Bansal, Leandro Beltrachini, Christian G Benar, Giacomo Bertazzoli, Suyash Bhogawar, Ross W Blair, Marta Bortoletto, Mathieu Boudreau, Teon L Brooks, Vince D Calhoun, Filippo Maria Castelli, Patricia Clement, Alexander L Cohen, Julien Cohen-Adad, Sasha D'Ambrosio, Gilles de Hollander, María de la Iglesia-Vayá, Alejandro de la Vega, Arnaud Delorme, Orrin Devinsky, Dejan Draschkow, Eugene Paul Duff, Elizabeth DuPre, Eric Earl, Oscar Esteban, Franklin W Feingold, Guillaume Flandin, Anthony Galassi, Giuseppe Gallitto, Melanie Ganz, Rémi Gau, James Gholam, Satrajit S Ghosh, Alessio Giacomel, Ashley G Gillman, Padraig Gleeson, Alexandre Gramfort, Samuel Guay, Giacomo Guidali, Yaroslav O Halchenko, Daniel A Handwerker, Nell Hardcastle, Peer Herholz, Dora Hermes, Christopher J Honey, Robert B Innis, Horea-Ioan Ioanas, Andrew Jahn, Agah Karakuzu, David B Keator, Gregory Kiar, Balint Kincses, Angela R Laird, Jonathan C Lau, Alberto Lazari, Jon Haitz Legarreta, Adam Li, Xiangrui Li, Bradley C Love, Hanzhang Lu, Camille Maumet, Giacomo Mazzamuto, Steven L Meisler, Mark Mikkelsen, Henk Mutsaerts, Thomas E Nichols, Aki Nikolaidis, Gustav Nilsonne, Guiomar Niso, Martin Norgaard, Thomas W Okell, Robert Oostenveld, Eduard Ort, Patrick J Park, Mateusz Pawlik, Cyril R Pernet, Franco Pestilli, Jan Petr, Christophe Phillips, Jean-Baptiste Poline, Luca Pollonini, Pradeep Reddy Raamana, Petra Ritter, Gaia Rizzo, Kay A Robbins, Alexander P Rockhill, Christine Rogers, Ariel Rokem, Chris Rorden, Alexandre Routier, Jose Manuel Saborit-Torres, Taylor Salo, Michael Schirner, Robert E Smith, Tamas Spisak, Julia Sprenger, Nicole C Swann, Martin Szinte, Sylvain Takerkart, Bertrand Thirion, Adam G Thomas, Sajjad Torabian, Gael Varoquaux, Bradley Voytek, Julius Welzel, Martin Wilson, Tal Yarkoni, Krzysztof J Gorgolewski
The Brain Imaging Data Structure (BIDS) is a community-driven standard for the organization of data and metadata from a growing range of neuroscience modalities. This paper is meant as a history of how the standard has developed and grown over time. We outline the principles behind the project, the mechanisms by which it has been extended, and some of the challenges being addressed as it evolves. We also discuss the lessons learned through the project, with the aim of enabling researchers in other domains to learn from the success of BIDS...
September 11, 2023: ArXiv
#4
JOURNAL ARTICLE
Eric D Miller, Trudy Wu, Grant McKinley, Jeremy Slivnick, Avirup Guha, Xiaokui Mo, Rahul Prasad, Vedat Yildiz, Dayssy Diaz, Robert E Merritt, Kyle A Perry, Ning Jin, Dinah Hodge, Michael Poliner, Sunnia Chen, John Gambril, James Stock, Jameson Wilbur, Jovan Pierre-Charles, Sanam M Ghazi, Terence M Williams, Jose G Bazan, Daniel Addison
BACKGROUND: Radiotherapy (RT) associates with long-term cardiotoxicity. In preclinical models, RT-exposure induces early cardiotoxic arrhythmias including atrial fibrillation (AF). Yet, whether this occurs in patients is unknown. METHODS: Leveraging a large cohort of consecutive esophageal cancer patients treated with thoracic-RT from 2007-2019, we assessed incidence and outcomes of incident-AF. Secondary outcomes included major adverse cardiovascular events (MACE), defined as AF, heart failure, ventricular-arrhythmias and sudden-death, by cardiac RT-dose...
August 11, 2023: International Journal of Radiation Oncology, Biology, Physics
#5
JOURNAL ARTICLE
Joshua R Heyza, Elmira Ekinci, Jacob Lindquist, Wen Lei, Christopher Yunker, Vilvanathan Vinothkumar, Rachelle Rowbotham, Lisa Polin, Natalie G Snider, Eric Van Buren, Donovan Watza, Jessica B Back, Wei Chen, Hirva Mamdani, Ann G Schwartz, John J Turchi, Gerold Bepler, Steve M Patrick
ERCC1/XPF is a heterodimeric DNA endonuclease critical for repair of certain chemotherapeutic agents. We recently identified that ERCC1- and p53-deficient lung cancer cells are tolerant to platinum-based chemotherapy. ATR inhibition synergistically re-stored platinum sensitivity to platinum tolerant ERCC1-deficient cells. Mechanistically we show this effect is reliant upon several functions of ATR including replication fork protection and altered cell cycle checkpoints. Utilizing an inhibitor of replication protein A (RPA), we further demonstrate that replication fork protection and RPA availability are critical for platinum-based drug tolerance...
March 2023: NAR cancer
#6
MULTICENTER STUDY
Samuel J Gentle, Benjamin Carper, Matthew M Laughon, Erik A Jensen, Austin Williams, Colm P Travers, Namasivayam Ambalavanan, Charitharth V Lal, Waldemar A Carlo
OBJECTIVE: To determine whether the duration of noninvasive respiratory support exposure is associated with bronchopulmonary dysplasia (BPD) or death in preterm infants. METHODS: Multicenter, retrospective study of infants born at <29 weeks' gestation. The association between days on noninvasive respiratory support and BPD or death was determined using instrumental variable techniques and generalized propensity score matching to account for potential confounding by illness severity...
April 2022: Journal of Perinatology: Official Journal of the California Perinatal Association
#7
Cían J Henry, Gergana Semova, Ellen Barnes, Isabel Cotter, Tara Devers, Aisyah Rafaee, Andreea Slavescu, Niamh O Cathain, Danielle McCollum, Edna Roche, David Mockler, John Allen, Judith Meehan, Claus Klingenberg, Jos M Latour, Agnes van den Hoogen, Tobias Strunk, Eric Giannoni, Luregn J Schlapbach, Marina Degtyareva, Frans B Plötz, Willem P de Boode, Lars Naver, James L Wynn, Helmut Küster, Jan Janota, Fleur M Keij, Irwin K M Reiss, Joseph M Bliss, Richard Polin, Joyce M Koenig, Mark A Turner, Christopher Gale, Eleanor J Molloy
BACKGROUND: The lack of a consensus definition of neonatal sepsis and a core outcome set (COS) proves a substantial impediment to research that influences policy and practice relevant to key stakeholders, patients and parents. METHODS: A systematic review of the literature was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. In the included studies, the described outcomes were extracted in accordance with the provisions of the Core Outcome Measures in Effectiveness Trials (COMET) handbook and registered...
March 2022: Pediatric Research
#8
Rían Hayes, Jack Hartnett, Gergana Semova, Cian Murray, Katherine Murphy, Leah Carroll, Helena Plapp, Louise Hession, Jonathan O'Toole, Danielle McCollum, Edna Roche, Elinor Jenkins, David Mockler, Tim Hurley, Matthew McGovern, John Allen, Judith Meehan, Frans B Plötz, Tobias Strunk, Willem P de Boode, Richard Polin, James L Wynn, Marina Degtyareva, Helmut Küster, Jan Janota, Eric Giannoni, Luregn J Schlapbach, Fleur M Keij, Irwin K M Reiss, Joseph Bliss, Joyce M Koenig, Mark A Turner, Christopher Gale, Eleanor J Molloy
INTRODUCTION: Neonatal sepsis is a leading cause of infant mortality worldwide with non-specific and varied presentation. We aimed to catalogue the current definitions of neonatal sepsis in published randomised controlled trials (RCTs). METHOD: A systematic search of the Embase and Cochrane databases was performed for RCTs which explicitly stated a definition for neonatal sepsis. Definitions were sub-divided into five primary criteria for infection (culture, laboratory findings, clinical signs, radiological evidence and risk factors) and stratified by qualifiers (early/late-onset and likelihood of sepsis)...
April 2023: Pediatric Research
#9
Mathew Birdsall Abrams, Jan G Bjaalie, Samir Das, Gary F Egan, Satrajit S Ghosh, Wojtek J Goscinski, Jeffrey S Grethe, Jeanette Hellgren Kotaleski, Eric Tatt Wei Ho, David N Kennedy, Linda J Lanyon, Trygve B Leergaard, Helen S Mayberg, Luciano Milanesi, Roman Mouček, J B Poline, Prasun K Roy, Stephen C Strother, Tong Boon Tang, Paul Tiesinga, Thomas Wachtler, Daniel K Wójcik, Maryann E Martone
No abstract text is available yet for this article.
April 13, 2021: Neuroinformatics
#10
JOURNAL ARTICLE
Adam C Adler, Anna Daszkowski, Joy C Tan, Anna D Poliner, Eric Z Wei, Brian H Nathanson, Arvind Chandrakantan
BACKGROUND: Dexmedetomidine is used to reduce opioid consumption in pediatric anesthesia. However, there is conflicting evidence in pediatric adenotonsillectomy literature regarding the total perioperative opioid-sparing effects of dexmedetomidine. The aim of this study was to examine the association between dexmedetomidine and total perioperative opioid consumption in children undergoing adenotonsillectomy. METHODS: This was a retrospective cohort study of the children undergoing adenotonsillectomy surgery at Texas Children's Hospital between November 2017 and October 2018...
November 1, 2021: Anesthesia and Analgesia
#11
REVIEW
Mathew Birdsall Abrams, Jan G Bjaalie, Samir Das, Gary F Egan, Satrajit S Ghosh, Wojtek J Goscinski, Jeffrey S Grethe, Jeanette Hellgren Kotaleski, Eric Tatt Wei Ho, David N Kennedy, Linda J Lanyon, Trygve B Leergaard, Helen S Mayberg, Luciano Milanesi, Roman Mouček, J B Poline, Prasun K Roy, Stephen C Strother, Tong Boon Tang, Paul Tiesinga, Thomas Wachtler, Daniel K Wójcik, Maryann E Martone
There is great need for coordination around standards and best practices in neuroscience to support efforts to make neuroscience a data-centric discipline. Major brain initiatives launched around the world are poised to generate huge stores of neuroscience data. At the same time, neuroscience, like many domains in biomedicine, is confronting the issues of transparency, rigor, and reproducibility. Widely used, validated standards and best practices are key to addressing the challenges in both big and small data science, as they are essential for integrating diverse data and for developing a robust, effective, and sustainable infrastructure to support open and reproducible neuroscience...
January 2022: Neuroinformatics
#12
RANDOMIZED CONTROLLED TRIAL
Jordan T Russell, J Lauren Ruoss, Diomel de la Cruz, Nan Li, Catalina Bazacliu, Laura Patton, Kelley Lobean McKinley, Timothy J Garrett, Richard A Polin, Eric W Triplett, Josef Neu
Antibiotic use in neonates can have detrimental effects on the developing gut microbiome, increasing the risk of morbidity. A majority of preterm neonates receive antibiotics after birth without clear evidence to guide this practice. Here microbiome, metabolomic, and immune marker results from the routine early antibiotic use in symptomatic preterm Neonates (REASON) study are presented. The REASON study is the first trial to randomize symptomatic preterm neonates to receive or not receive antibiotics in the first 48 h after birth...
January 21, 2021: Scientific Reports
#13
JOURNAL ARTICLE
Yanhai Gong, Nam K Kang, Young U Kim, Zengbin Wang, Li Wei, Yi Xin, Chen Shen, Qintao Wang, Wuxin You, Jong-Min Lim, Suk-Won Jeong, Youn-Il Park, Hee-Mock Oh, Kehou Pan, Eric Poliner, Guanpin Yang, Yonghua Li-Beisson, Yantao Li, Qiang Hu, Ansgar Poetsch, Eva M Farre, Yong K Chang, Won-Joong Jeong, Byeong-Ryool Jeong, Jian Xu
Nannochloropsis species, unicellular industrial oleaginous microalgae, are model organisms for microalgal systems and synthetic biology. To facilitate community-based annotation and mining of the rapidly accumulating functional genomics resources, we have initiated an international consortium and present a comprehensive multi-omics resource database named Nannochloropsis Design and Synthesis (NanDeSyn; https://nandesyn.single-cell.cn). Via the Tripal toolkit, it features user-friendly interfaces hosting genomic resources with gene annotations and transcriptomic and proteomic data for six Nannochloropsis species, including two updated genomes of Nannochloropsis oceanica IMET1 and Nannochloropsis salina CCMP1776...
December 2020: Plant Journal
#14
RANDOMIZED CONTROLLED TRIAL
J Lauren Ruoss, Catalina Bazacliu, Jordan T Russell, Diomel de la Cruz, Nan Li, Matthew J Gurka, Stephanie L Filipp, Richard A Polin, Eric W Triplett, Josef Neu
We enrolled 98 infants (gestational age <33 weeks) in a pilot randomized trial of antibiotics vs no antibiotics; 55 were randomized (lower maternal infectious risk; symptoms expected for gestation). Adverse events did not differ significantly between the randomization arms. This trial establishes a framework for a larger multicentered trial.
February 2021: Journal of Pediatrics
#15
JOURNAL ARTICLE
Laura Patton, Nan Li, Timothy J Garrett, J Lauren Ruoss, Jordan T Russell, Diomel de la Cruz, Catalina Bazacliu, Richard A Polin, Eric W Triplett, Josef Neu
Within a randomized prospective pilot study of preterm infants born at less than 33 weeks' gestation, weekly fecal samples from 19 infants were collected and metabolomic analysis was performed. The objective was to evaluate for differences in fecal metabolites in infants exposed to antibiotics vs. not exposed to antibiotics in the first 48 h after birth. Metabolomics analysis was performed on 123 stool samples. Significant differences were seen in the antibiotics vs. no antibiotics groups, including pathways related to vitamin biosynthesis, bile acids, amino acid metabolism, and neurotransmitters...
August 13, 2020: Metabolites
#16
RANDOMIZED CONTROLLED TRIAL
William C W Wong, Nancy S Yang, Jingjing Li, Hang Li, Eric Y F Wan, Thomas Fitzpatrick, Yuan Xiong, Wai-Kay Seto, Polin Chan, Ruihong Liu, Weiming Tang, Joseph D Tucker
BACKGROUND: Hepatitis C virus (HCV) is a growing public health problem with a large disease burden worldwide. In China many people living with HCV are unaware of their hepatitis status and not connected to care and treatment. Crowdsourcing is a technique that invites the public to create health promotion materials and has been found to increase HIV testing uptake, including in China. This trial aims to evaluate crowdsourcing as a strategy to improve HCV awareness, testing and linkage-to-care in China...
July 2, 2020: BMC Public Health
#17
JOURNAL ARTICLE
Tomomi Takeuchi, Barbara B Sears, Chase Lindeboom, Yang-Tsung Lin, Nicholas Fekaris, Krzysztof Zienkiewicz, Agnieszka Zienkiewicz, Eric Poliner, Christoph Benning
COMPROMISED HYDROLYSIS OF TRIACYLGLYCEROLS7 (CHT7) in Chlamydomonas ( Chlamydomonas reinhardtii ) was previously shown to affect the transcription of a subset of genes during nitrogen (N)-replete growth and following N refeeding. Here, we show that an extensive derepression of genes involved in DNA metabolism and cell cycle-related processes, as well as downregulation of genes encoding oxidoreductases and nutrient transporters, occurs in the cht7 mutant during N deprivation. Cellular mutant phenotypes are consistent with the observed transcriptome misregulation, as cht7 cells fail to properly arrest growth, nuclear replication, and cell division following N deprivation...
April 2020: Plant Cell
#18
JOURNAL ARTICLE
Claire Cury, Marzia Antonella Scelsi, Roberto Toro, Vincent Frouin, Eric Artiges, Antoine Grigis, Andreas Heinz, Hervé Lemaître, Jean-Luc Martinot, Jean-Baptiste Poline, Michael N Smolka, Henrik Walter, Gunter Schumann, Andre Altmann, Olivier Colliot
Incomplete hippocampal inversion (IHI), also called hippocampal malrotation, is an atypical presentation of the hippocampus present in about 20% of healthy individuals. Here we conducted the first genome-wide association study (GWAS) in IHI to elucidate the genetic underpinnings that may contribute to the incomplete inversion during brain development. A total of 1381 subjects contributed to the discovery cohort obtained from the IMAGEN database. The incidence rate of IHI was 26.1%. Loci with P<1e-5 were followed up in a validation cohort comprising 161 subjects from the PING study...
2020: PloS One
#19
JOURNAL ARTICLE
Agnieszka Zienkiewicz, Krzysztof Zienkiewicz, Eric Poliner, Jane A Pulman, Zhi-Yan Du, Giovanni Stefano, Chia-Hong Tsai, Patrick Horn, Ivo Feussner, Eva M Farre, Kevin L Childs, Federica Brandizzi, Christoph Benning
The marine microalgae Nannochloropsis oceanica (CCMP1779) is a prolific producer of oil and is considered a viable and sustainable resource for biofuel feedstocks. Nitrogen (N) availability has a strong impact on the physiological status and metabolism of microalgal cells, but the exact nature of this response is poorly understood. To fill this gap we performed transcriptomic profiling combined with cellular and molecular analyses of N. oceanica CCMP1779 during the transition from quiescence to autotrophy. N deprivation-induced quiescence was accompanied by a strong reorganization of the photosynthetic apparatus and changes in the lipid homeostasis, leading to accumulation of triacylglycerol...
February 2020: Plant Physiology
#20
JOURNAL ARTICLE
Eric Poliner, Tomomi Takeuchi, Zhi-Yan Du, Christoph Benning, Eva M Farré
Utilization of microalgae has been hampered by limited tools for creating loss-of-function mutants. Furthermore, modified strains for deployment into the field must be free of antibiotic resistance genes and face fewer regulatory hurdles if they are transgene free. The oleaginous microalga, Nannochloropsis oceanica CCMP1779, is an emerging model for microalgal lipid metabolism. We present a one-vector episomal CRISPR/Cas9 system for N. oceanica that enables the generation of marker-free mutant lines. The CEN/ARS6 region from Saccharomyces cerevisiae was included in the vector to facilitate its maintenance as circular extrachromosal DNA...
April 20, 2018: ACS Synthetic Biology
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