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Macular perfusion

Julia Hafner, Sonja Karst, Stefan Sacu, Christoph Scholda, Eleonore Pablik, Ursula Schmidt-Erfurth
PURPOSE: The pathophysiology of diabetic neurodegeneration and microvasculopathy remains controversial. Neurosensory layer thickness and corneal nerve fibre loss represent potential biomarkers of neuropathy. The purpose of this cross-sectional study was to determine the correlation between these neurodegenerative features and their association with retinal microvascular integrity in patients with type II diabetes without retinopathy. METHODS: Nerve fibre length (NFL), density (NFD) and branch density (NBD) were assessed using corneal confocal microscopy...
October 11, 2018: Acta Ophthalmologica
Xiaogang Wang, Bin Sun, Jie Wang, Yali Jia, David Huang, Jing Dong
RATIONALE: Retinal artery occlusion (RAO) results in painless, catastrophic vision loss in a period of seconds. Optical coherence tomography angiography (OCTA) can image retinal microcirculation, which is helpful to evaluate treatment response during the follow-up period. Using a single case with central RAO, we report its retinal perfusion changes before and after treatment using OCTA. PATIENT CONCERNS: A 36-year-old Chinese man came to our clinic with a sudden, painless loss of vision (hand motion) in his left eye...
October 2018: Medicine (Baltimore)
Sung Uk Baek, Jin-Soo Kim, Young Kook Kim, Jin Wook Jeoung, Ki Ho Park
PURPOSE: To investigate, in primary open-angle glaucoma (POAG) and healthy subjects, the pattern and magnitude of diurnal variation in macular choroidal thickness (mCT). METHODS: A prospective study was conducted on Koreans comprising 21 patients with POAG and 17 healthy subjects. All underwent mCT, systemic blood pressure (BP), and intraocular pressure (IOP) measurements during the daytime at five time points (8 AM, 11 AM, 2 PM, 5 PM and 8 PM). The mCT was determined at five sites using swept-source optical coherence tomography...
September 18, 2018: Journal of Glaucoma
Amal M Elbendary, Hossam Youssef Abouelkheir
AIM: To categorize neovessels morphology and to detect response to anti-angiogenic therapy by using structural and angiographic modes of swept source optical coherence tomography (SS-OCT). METHODS: Thirty-two eyes with neovessels at disc (NVD) and neovessels elsewhere (NVE) - as diagnosed by fluorescein angiography- were included. Cross sectional OCT images of disc and macular regions were registered to enface OCT angiography (OCTA), B-scan blood flow over lay and density maps...
2018: International Journal of Ophthalmology
Felipe F Conti, Jason M Young, Fabiana Q Silva, Eduardo B Rodrigues, Rishi P Singh
BACKGROUND AND OBJECTIVE: To evaluate the repeatability of retinal thickness and vascular density measurements using split-spectrum amplitude-decorrelation angiography (SSADA) with optical coherence tomography (OCT). PATIENTS AND METHODS: Forty patients were divided into seven categories according to their diagnosis: no retinopathy (control), retinal vein occlusion, diabetes with no retinopathy, diabetes with retinopathy, non-exudative age-related macular degeneration (AMD), exudative AMD, and epiretinal membrane...
September 1, 2018: Ophthalmic Surgery, Lasers & Imaging Retina
Heba Radi AttaAllah, Asmaa Anwar Mohamed Mohamed, Mohamed Attia Ali
PURPOSE: The aim of this study was to evaluate macular perfusion using OCTA automated software algorithms; vessel area density (VD) and non-flow tool to measure FAZ area in treatment-naïve diabetic eyes with moderate or severe NPDR and having macular edema, and correlate these parameters with LogMAR (logarithm of the minimum angle of resolution) visual acuity. Diabetic eyes without macular edema were included, to detect and define differences within the parameters between diabetic eyes with and without macular edema...
September 7, 2018: International Ophthalmology
Felice Cardillo Piccolino, Marco Lupidi, Carlo Cagini, Daniela Fruttini, Massimo Nicolò, Chiara Maria Eandi, Silvia Tito
Purpose: To investigate the retinal vascular response to the isometric exercise in patients with central serous chorioretinopathy (CSCR) by using optical coherence tomography angiography (OCT-A). Methods: This was a multicenter case-control study including 35 CSCR patients and 25 age-matched healthy controls. All subjects underwent macular OCT-A scans in resting conditions and during a handgrip isometric exercise. Hemodynamic data, such as systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), and ocular perfusion pressure (OPP), were recorded at baseline and during the stress test...
September 4, 2018: Investigative Ophthalmology & Visual Science
N I Kurysheva, E V Maslova, A V Trubilina, A V Fomin, M B Lagutin
PURPOSE: To study microcirculatory and functional changes in macula in patients with Primary Open-Angle Glaucoma (POAG). MATERIAL AND METHODS: The study included 95 POAG patients and 42 healthy control subjects. Whole en face image vessel density (wiVDRetina) was measured both in fovea and in parafovea using OCT-angiography (OCT-A) by means of SD-OCT AngioVue on Avanti RtVue xR (Optovue Inc., U.S.A.). Macular thickness and parameters of macular ganglion cell complex (GCC) were measured on the same day...
2018: Vestnik Oftalmologii
Hyung Bin Lim, Yong Woo Kim, Ju Mi Kim, Young Joon Jo, Jung Yeul Kim
The quality of the scan image is important in microvascular circulation analysis using optical coherence tomography (OCTA). We aimed to investigate the effect of signal strength (SS) on OCTA metrics and minimum SS level that could be considered optimal. Macular 6 × 6 mm angiography images were acquired, and all subjects were divided into four groups according to the SS (SS 7, SS 8, SS 9, and SS 10) of the OCTA image. Vessel density (VD), perfusion density (PD), and foveal avascular zone (FAZ) metrics of the superficial capillary plexus were compared...
August 27, 2018: Scientific Reports
Giovana Rosa Gameiro, Hong Jiang, Yi Liu, Yuqing Deng, Xiaoyan Sun, Bernardo Nascentes, Bernard Baumel, Tatjana Rundek, Jianhua Wang
Background: It remains unknow whether retinal tissue perfusion occurs in patients with Alzheimer's disease. The goal was to determine retinal tissue perfusion in patients with clinical Alzheimer's disease (CAD). Methods: Twenty-four CAD patients and 19 cognitively normal (CN) age-matched controls were recruited. A retinal function imager (RFI, Optical Imaging Ltd., Rehovot, Israel) was used to measure the retinal blood flow supplying the macular area of a diameter of 2...
2018: Eye and Vision (London, England)
Elisabetta Pilotto, Francesca Leonardi, Giuseppe Stefanon, Evelyn Longhin, Tommaso Torresin, Davide Deganello, Fabiano Cavarzeran, Giacomo Miglionico, Raffaele Parrozzani, Edoardo Midena
PURPOSE: To evaluate, by means of optical coherence tomography (OCT) and OCT angiography (OCTA), early retinal, choroidal and macular perfusion changes induced by a local inflammatory reaction secondary to uncomplicated cataract surgery. METHODS: Selected eyes undergoing cataract surgery were enrolled in a prospective study. OCT and OCTA were performed before cataract surgery (T0) and at day: 1 (T1), 7 (T7), 30 (T30) and 90 (T90). Inner (IR) and outer retinal (OR) volumes, choroidal volume, hyper-reflective retinal spots (HRS) in IR and OR changes were measured at OCT...
August 20, 2018: British Journal of Ophthalmology
Gabriele E Lang, Stefan J Lang
Retinal vein occlusions (RVO) are common retinal diseases. They are caused by an obstruction of retinal veins. RVO often result in visual deterioration and, in rare cases, can lead to blindness, but also be asymptomatic. The prognosis is various and depends on the extent, the localization of the occlusion and the retinal perfusion, especially in the macular area. The etiology often is a thrombosis caused by vascular sclerosis, rarely a vasculitis. Because often an underlying disease is present the medical clarification is necessary...
August 20, 2018: Klinische Monatsblätter Für Augenheilkunde
Daniel Su, Sunir Garg
Background: The Retinal Function Imager (RFI) provides in vivo and noninvasive imaging of both the retinal structure and function. Review: The RFI can create capillary perfusion maps, measure blood flow velocity, and determine metabolic function including blood oximetry. It can aid clinical diagnosis as well as assess treatment response in several retinal vascular diseases including diabetic retinopathy. Blood flow velocity abnormalities have also been implicated in disease such as age-related macular degeneration and require further investigation...
2018: Eye and Vision (London, England)
Andrew W Francis, Ivy Zhu, Sidhiporn Borirakchanyavat, Daniel M Schwartz, David G Hwang
PURPOSE: To report a central retinal artery occlusion with cilioretinal artery sparing in a 48-year-old woman after laser-assisted in situ keratomileusis surgery. METHODS: Case history and clinical examination including best-corrected visual acuity, serum markers, slit-lamp biomicroscopy, indirect ophthalmoscopy, fundus photography, fluorescein angiography, and optical coherence tomography. RESULTS: A 48-year-old woman underwent routine laser-assisted in situ keratomileusis surgery in both eyes...
August 10, 2018: Retinal Cases & Brief Reports
Soojin Lim, Cheng-Kuo Cheng, Yi-Hsuan Li
Purpose: Amalric triangular sign is a rare phenomenon indicating choroidal ischemia. In this study, we reported a typical Amalric triangular sign in a case of central retinal artery occlusion (CRAO) combined with posterior ciliary artery (PCA) occlusion. Observations: A 49-year-old women developed sudden visual loss in her left eye for one day. Ocular examination revealed rubeosis iridis, macular retinal edema followed by multiple whitish triangular patches in the peripheral four days later...
September 2018: American Journal of Ophthalmology Case Reports
Maximilian W M Wintergerst, Maximilian Pfau, Philipp L Müller, Moritz Berger, Luis de Sisternes, Frank G Holz, Robert P Finger
PURPOSE: To investigate the involvement of the retinal and choriocapillaris microvasculature in intermediate uveitis on optical coherence tomography angiography (OCT-A). DESIGN: Case-control study. METHODS: Patients and age-matched controls were imaged with swept-source OCT-A. Using ImageJ, superficial and deep retinal vasculature were semi-automatically analyzed for vessel (VD) and skeleton density (SD), vessel diameter index (VDI), and fractal dimension (FD)...
October 2018: American Journal of Ophthalmology
Takahiro Kogo, Yuki Muraoka, Sotaro Ooto, Kiyoshi Suzuma, Tomoaki Murakami, Yuto Iida, Yuko Iida-Miwa, Rima Ghashut, Manabu Miyata, Akitaka Tsujikawa
PURPOSE: To evaluate fixation status of eyes with branch retinal vein occlusion (BRVO) and to investigate its association with other clinical parameters. METHODS: This study included 57 consecutive eyes with BRVO after resolution of macular edema. Fixation status was determined by microperimetry. Defect length of the foveal ellipsoid zone band was measured by optical coherence tomography, and retinal perfusion status was assessed by optical coherence tomography angiography...
July 13, 2018: Retina
Guodong Liu, Ding Xu, Fang Wang
Diabetic retinopathy (DR) is one of the most common diabetic complications, which has become a leading cause for vision loss, mainly because of macular edema and vitreous hemorrhage. Optical coherence tomography (OCT) angiography is a novel technique to visualize vascular changes including microaneurysm, non-perfusion area, intraretinal microvascular abnormalities, and neovascularization. Recently, it is possible to quantify vascular density, foveal avascular zone area, non-perfusion area objectively using OCT angiography...
August 2018: Diabetes Research and Clinical Practice
Paolo Milani, Giovanni Montesano, Luca Rossetti, Fulvio Bergamini, Alfredo Pece
PURPOSE: To investigate foveal avascular zone area, macular vascular density, choroidal thickness, and outer retina and choriocapillaris flow in myopic eyes by OCT angiography. METHODS: Automated macular maps and flow calculations were retrospectively evaluated in 42 myopic and in 40 control eyes. RESULTS: Myopic eyes presented lower whole superficial vessel density (46.4 ± 4.9 vs. 51.6 ± 3.6%, P < 0.0001) and higher flow area in the outer retina (1...
June 6, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
Andrew Winegarner, Taku Wakabayashi, Yoko Fukushima, Tatsuhiko Sato, Chikako Hara-Ueno, Caleb Busch, Issei Nishiyama, Nobuhiko Shiraki, Kaori Sayanagi, Kentaro Nishida, Hirokazu Sakaguchi, Kohji Nishida
Purpose: To investigate the changes in the retinal microvasculature during the course of anti-VEGF therapy in eyes with macular edema due to retinal vein occlusion (RVO) and their association with visual outcomes. Methods: The vessel density (VD) and foveal avascular zone (FAZ) area in the superficial capillary plexus (SCP) and deep capillary plexus (DCP) were quantitatively measured by optical coherence tomography angiography (OCTA) in 48 consecutive eyes with RVO before and 1, 3, 6, 9, and 12 months after anti-VEGF therapy...
June 1, 2018: Investigative Ophthalmology & Visual Science
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