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Macular perfusion

Shota Yasukura, Tomoaki Murakami, Kiyoshi Suzuma, Tatsuya Yoshitake, Hideo Nakanishi, Masahiro Fujimoto, Maho Oishi, Akitaka Tsujikawa
Purpose: To investigate the nonperfused areas (NPAs) in each subfield segmented by large arterioles on wide-field swept-source optical coherence tomography angiography (SS-OCTA) images in diabetic retinopathy. Methods: We retrospectively reviewed 101 consecutive eyes of 67 patients with severe nonproliferative diabetic retinopathy (NPDR) and proliferative diabetic retinopathy (PDR), for whom 12 × 12-mm SS-OCTA images centered on the optic disc were acquired. Both eyes were included in 34 patients...
December 3, 2018: Investigative Ophthalmology & Visual Science
Guofan Cao, Xiangzhong Xu, Chenghu Wang, Shu Zhang
PURPOSE: To compare the outcome of the sequence in the two treatments (intravitreal ranibizumab and panretinal photocoagulation) in high-risk proliferative diabetic retinopathy. METHODS: This retrospective study included 35 patients with newly diagnosed high-risk proliferative diabetic retinopathy in 43 eyes; 18 (22 eyes) received intravitreal ranibizumab before panretinal photocoagulation (intravitreal ranibizumab+ group), while the other 17 (21 eyes) received panretinal photocoagulation before intravitreal ranibizumab (panretinal photocoagulation+ group)...
December 12, 2018: European Journal of Ophthalmology
Haiyun Ye, Ce Zheng, Xiaoping Lan, Limin Zhao, Tong Qiao, Xiaoyan Li, Yidan Zhang
PURPOSE: To evaluate the effect of adenoidectomy on the brains of children with obstructive sleep apnea-hypopnea syndrome (OSAS) through observation of the alteration of retinal perfusion by optical coherence tomography angiography (OCTA). METHODS: Sixty-two children with OSAS (124 eyes; 5.94 ± 1.64 years old; 53.2% boys) were enrolled in this study. Their retinal vascular network density indices, including vascular diameter (VD), vascular area density (VAD), vessel skeleton density (VSD), vessel perimeter index (VPI) on the macular superficial/deep capillary plexus (SCP/DCP), and the size of the foveal avascular zone (FAZ) were analyzed by OCTA before treatment and at 1 month after the adenoidectomy...
December 12, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
Meng Tian, Christoph Tappeiner, Martin S Zinkernagel, Wolfgang Huf, Sebastian Wolf, Marion R Munk
PURPOSE: To evaluate vascular changes in patients with intermediate uveitis with or without retinal vasculitis using swept-source wide-field optical coherence tomography angiography (OCTA). METHODS: This is a prospective cross-sectional study. Consecutive patients with intermediate uveitis were evaluated using wide-field OCTA. Wide-field OCTA and en-face OCT images were analysed for the presence of capillary non-perfusion and reduced perfusion, disruption of ellipsoid zone, and abnormalities on en-face wide-field retinal thickness maps, respectively, and compared with fluorescein angiography (FA) findings in a subcohort...
December 11, 2018: British Journal of Ophthalmology
Hyung Bin Lim, Min Woo Lee, Jae Hyeong Park, Kyeung Min Kim, Young Joon Jo, Jung Yeul Kim
OBJECTIVE: To investigate retinal blood flow in patients with hypertension using optical coherence tomography angiography (OCTA) and the relationship between blood flow metrics and ganglion cell-inner plexiform layer (GC-IPL) thickness. DESIGN: Retrospective, cross-sectional study. METHODS: A total of 201 eyes from 117 healthy subjects and 84 hypertensive patients without any ocular abnormalities were included. Hypertensive patients were divided into the two groups according to disease periods (<5 years: hypertension group 1; ≥5 years: hypertension group 2)...
November 28, 2018: American Journal of Ophthalmology
Yukun Guo, Acner Camino, Jie Wang, David Huang, Thomas S Hwang, Yali Jia
Screening and assessing diabetic retinopathy (DR) are essential for reducing morbidity associated with diabetes. Macular ischemia is known to correlate with the severity of retinopathy. Recent studies have shown that optical coherence tomography angiography (OCTA), with intrinsic contrast from blood flow motion, is well suited for quantified analysis of the avascular area, which is potentially a useful biomarker in DR. In this study, we propose the first deep learning solution to segment the avascular area in OCTA of DR...
November 1, 2018: Biomedical Optics Express
Justin J Park, Christopher S Chung, Amani A Fawzi
BACKGROUND AND OBJECTIVE: To assess the relationship between retinal vascular and structural changes in the superficial, middle, and deep capillary plexuses (SCP, MCP, DCP) using optical coherence tomography angiography (OCTA) and en face OCT. PATIENTS AND METHODS: Patients with diabetic retinopathy were imaged using the Cirrus HD-OCT with AngioPlex. Using manual segmentation of the retinal layers, the authors compared OCTA to en face OCT images to examine corresponding patterns in each of the three capillary plexuses...
November 1, 2018: Ophthalmic Surgery, Lasers & Imaging Retina
Stela Vujosevic, Valentina Gatti, Andrea Muraca, Marco Brambilla, Edoardo Villani, Paolo Nucci, Luca Rossetti, Stefano De Cillaʼ
PURPOSE: To assess changes on optical coherence tomography (OCT) angiography in diabetic macular edema (DME) treated with subthreshold micropulse yellow laser (SMPL) over a period of 6 months. METHODS: Thirty-five eyes (35 consecutive patients) with treatment-naive DME prospectively underwent (at baseline, 3 and 6 months) best-corrected visual acuity, swept-source OCT angiography/OCT, and fundus autofluorescence. Following parameters were evaluated on OCT angiography in the superficial capillary plexus (SCP) and deep capillary plexus (DCP): the area of foveal avascular zone, number of microaneurysms (MA), area of cysts, and presence of capillary network alterations...
November 7, 2018: Retina
Cheolmin Yun, Jungah Huh, So Min Ahn, Boram Lee, Jee Taek Kim, Soon-Young Hwang, Seong-Woo Kim, Jaeryung Oh
PURPOSE: The purpose of the study is to investigate the characteristics of choriocapillaris flow based on the underlying choroidal vasculature in fellow eyes with central serous chorioretinopathy (CSC). METHODS: We included 57 patients with CSC and normal controls. Characteristics of choriocapillaris flow were evaluated using swept-source optical coherence tomography (OCT) angiography. We divided the choroidal layer into the vascular and stromal beds according to the choroid vessels on en-face OCT images...
November 5, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
Oliver Niels Klefter, Peter Kristian Kofoed, Inger Christine Munch, Michael Larsen
PURPOSE: To assess retinal perfusion in eyes with unilateral ocular ischaemic syndrome (OIS) and to compare with control subjects. METHODS: Retrospective case series. Linear blood flow velocities in macular vessels were estimated using motion-contrast fundus photography in eight patients with unilateral OIS (eight OIS eyes, seven fellow eyes) and 12 control subjects. The diagnosis of OIS was supported by carotid artery Doppler ultrasonography and pneumoplethysmographic measurement of ocular systolic perfusion pressure...
October 27, 2018: Acta Ophthalmologica
Stefano Sebastiani, Marco Pellegrini, Giuseppe Giannaccare, David Sarraf
PURPOSE: To present an atypical case of paracentral acute middle maculopathy occurred upon awakening in the morning within hours after phosphodiesterase-5 (PDE-5) inhibitor consumption at bedtime. METHODS: Multimodal retinal imaging findings, including fluorescein angiography, spectral domain optical coherence tomography, optical coherence tomography angiography, and microperimetry of a particular case of paracentral acute middle maculopathy lesion that follow the distribution of the cilioretinal artery...
October 25, 2018: Retinal Cases & Brief Reports
Stela Vujosevic, Andrea Muraca, Valentina Gatti, Luca Masoero, Marco Brambilla, Barbara Cannillo, Edoardo Villani, Paolo Nucci, Stefano De Cillà
Purpose: To evaluate peripapillary vessel density and morphology in patients with diabetes mellitus (DM) without clinical signs of diabetic retinopathy (DR) and with mild, nonproliferative DR and to correlate with peripapillary nerve fiber layer (NFL) thickness. Methods: One hundred seventeen eyes (34 healthy controls, 54 patients with DM without DR [noDR group] and 24 patients with mild DR [DR group]) were prospectively evaluated. All subjects underwent peripapillary and macular optical coherence tomography angiography (OCT-A)...
October 1, 2018: Investigative Ophthalmology & Visual Science
Salman Sarwar, Muhammad Hassan, Mohamed K Soliman, Muhammad Sohail Halim, Mohammad Ali Sadiq, Rubbia Afridi, Aniruddha Agarwal, Diana V Do, Quan Dong Nguyen, Yasir J Sepah
Background: Vessel flow density (VFD) may provide important information regarding perfusion status. Diurnal variation in VFD of choriocapillaris has not been reported in literature. In the index study, optical coherence tomography angiography (OCTA) was used to assess the diurnal variation of the VFD in the choriocapillaris of subjects with no known ocular disease. Methods: Fifty eyes with no known ocular disease (25 subjects) were included. OCTA images were acquired using AngioVue (Optovue, Fremont, CA, USA) at two different time points on a single day: 9:00 AM and 6:00 PM...
2018: International Journal of Retina and Vitreous
Julia Hafner, Sonja Karst, Stefan Sacu, Christoph Scholda, Eleonore Pablik, Ursula Schmidt-Erfurth
PURPOSE: The pathophysiology of diabetic neurodegeneration and microvasculopathy remains controversial. Neurosensory layer thickness and corneal nerve fibre loss represent potential biomarkers of neuropathy. The purpose of this cross-sectional study was to determine the correlation between these neurodegenerative features and their association with retinal microvascular integrity in patients with type II diabetes without retinopathy. METHODS: Nerve fibre length (NFL), density (NFD) and branch density (NBD) were assessed using corneal confocal microscopy...
October 11, 2018: Acta Ophthalmologica
Xiaogang Wang, Bin Sun, Jie Wang, Yali Jia, David Huang, Jing Dong
RATIONALE: Retinal artery occlusion (RAO) results in painless, catastrophic vision loss in a period of seconds. Optical coherence tomography angiography (OCTA) can image retinal microcirculation, which is helpful to evaluate treatment response during the follow-up period. Using a single case with central RAO, we report its retinal perfusion changes before and after treatment using OCTA. PATIENT CONCERNS: A 36-year-old Chinese man came to our clinic with a sudden, painless loss of vision (hand motion) in his left eye...
October 2018: Medicine (Baltimore)
Sung Uk Baek, Jin-Soo Kim, Young Kook Kim, Jin Wook Jeoung, Ki Ho Park
PURPOSE: To investigate, in primary open-angle glaucoma (POAG) and healthy subjects, the pattern and magnitude of diurnal variation in macular choroidal thickness (mCT). METHODS: A prospective study was conducted on Koreans comprising 21 patients with POAG and 17 healthy subjects. All underwent mCT, systemic blood pressure (BP), and intraocular pressure (IOP) measurements during the daytime at five time points (8 AM, 11 AM, 2 PM, 5 PM and 8 PM). The mCT was determined at five sites using swept-source optical coherence tomography...
September 18, 2018: Journal of Glaucoma
Amal M Elbendary, Hossam Youssef Abouelkheir
AIM: To categorize neovessels morphology and to detect response to anti-angiogenic therapy by using structural and angiographic modes of swept source optical coherence tomography (SS-OCT). METHODS: Thirty-two eyes with neovessels at disc (NVD) and neovessels elsewhere (NVE) - as diagnosed by fluorescein angiography- were included. Cross sectional OCT images of disc and macular regions were registered to enface OCT angiography (OCTA), B-scan blood flow over lay and density maps...
2018: International Journal of Ophthalmology
Felipe F Conti, Jason M Young, Fabiana Q Silva, Eduardo B Rodrigues, Rishi P Singh
BACKGROUND AND OBJECTIVE: To evaluate the repeatability of retinal thickness and vascular density measurements using split-spectrum amplitude-decorrelation angiography (SSADA) with optical coherence tomography (OCT). PATIENTS AND METHODS: Forty patients were divided into seven categories according to their diagnosis: no retinopathy (control), retinal vein occlusion, diabetes with no retinopathy, diabetes with retinopathy, non-exudative age-related macular degeneration (AMD), exudative AMD, and epiretinal membrane...
September 1, 2018: Ophthalmic Surgery, Lasers & Imaging Retina
Heba Radi AttaAllah, Asmaa Anwar Mohamed Mohamed, Mohamed Attia Ali
PURPOSE: The aim of this study was to evaluate macular perfusion using OCTA automated software algorithms; vessel area density (VD) and non-flow tool to measure FAZ area in treatment-naïve diabetic eyes with moderate or severe NPDR and having macular edema, and correlate these parameters with LogMAR (logarithm of the minimum angle of resolution) visual acuity. Diabetic eyes without macular edema were included, to detect and define differences within the parameters between diabetic eyes with and without macular edema...
September 7, 2018: International Ophthalmology
Felice Cardillo Piccolino, Marco Lupidi, Carlo Cagini, Daniela Fruttini, Massimo Nicolò, Chiara Maria Eandi, Silvia Tito
Purpose: To investigate the retinal vascular response to the isometric exercise in patients with central serous chorioretinopathy (CSCR) by using optical coherence tomography angiography (OCT-A). Methods: This was a multicenter case-control study including 35 CSCR patients and 25 age-matched healthy controls. All subjects underwent macular OCT-A scans in resting conditions and during a handgrip isometric exercise. Hemodynamic data, such as systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), and ocular perfusion pressure (OPP), were recorded at baseline and during the stress test...
September 4, 2018: Investigative Ophthalmology & Visual Science
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