keyword
https://read.qxmd.com/read/38300615/nahco3-loading-causes-increased-arterial-pressure-and-kidney-damage-in-rats-with-chronic-kidney-disease
#21
JOURNAL ARTICLE
Elinor C Mannon, P Robinson Muller, Jingping Sun, Weston B Bush, Alex Coleman, H Ocasio, A J Polichnowski, Michael W Brands, Paul M O'Connor
Sodium bicarbonate (NaHCO3) is commonly utilized as a therapeutic to treat metabolic acidosis in people with chronic kidney disease (CKD). While increased dietary sodium chloride (NaCl) is known to promote volume retention and increase blood pressure, the effects of NaHCO3 loading on blood pressure and volume retention in CKD remain unclear. In the current study, we compared the effects of NaCl and NaHCO3 loading on volume retention, blood pressure, and kidney injury in both 2/3rd and 5/6th nephrectomy remnant kidney rats, a well-established rodent model of CKD...
February 1, 2024: Clinical Science (1979-)
https://read.qxmd.com/read/38255734/primary-role-of-the-kidney-in-pathogenesis-of-hypertension
#22
REVIEW
Gheun-Ho Kim
Previous transplantation studies and the concept of 'nephron underdosing' support the idea that the kidney plays a crucial role in the development of essential hypertension. This suggests that there are genetic factors in the kidney that can either elevate or decrease blood pressure. The kidney normally maintains arterial pressure within a narrow range by employing the mechanism of pressure-natriuresis. Hypertension is induced when the pressure-natriuresis mechanism fails due to both subtle and overt kidney abnormalities...
January 14, 2024: Life
https://read.qxmd.com/read/38255411/the-future-for-the-children-of-tomorrow-avoiding-salt-in-the-first-1000-days
#23
REVIEW
Giorgia Mazzuca, Silvia Artusa, Angelo Pietrobelli, Giuseppe Di Cara, Giorgio Piacentini, Luca Pecoraro
It is widely known that optimal nutrition in the first 1000 days of life positively impacts the child's development throughout adulthood. In this setting, salt should not be added to complementary feeding. In developed countries, salt intake is generally higher than recommended for children. Excessive salt intake is the major determinant of hypertension and is associated with several cardiovascular outcomes. Therefore, pediatricians have a key role in raising awareness among parents to avoid salt consumption in the first 1000 days of life to ensure better health for their children...
January 14, 2024: Children
https://read.qxmd.com/read/38242697/alleviating-hypertension-by-selectively-targeting-angiotensin-receptor-expressing-vagal-sensory-neurons
#24
JOURNAL ARTICLE
Caitlin Baumer-Harrison, Khalid Elsaafien, Dominique N Johnson, Jesus D PeƱaloza Aponte, Alan de Araujo, Sagar Patel, Erin Bruce, Scott W Harden, Charles J Frazier, Karen A Scott, Guillaume de Lartigue, Eric G Krause, Annette D de Kloet
Cardiovascular homeostasis is maintained, in part, by neural signals arising from arterial baroreceptors that apprise the brain of blood volume and pressure. Here, we test whether neurons within the nodose ganglia that express angiotensin type-1a receptors (referred to as NGAT1aR ) serve as baroreceptors that differentially influence blood pressure (BP) in male and female mice. Using Agtr1a -Cre mice and Cre-dependent AAVs to direct tdTomato to NGAT1aR , neuroanatomical studies revealed that NGAT1aR receive input from the aortic arch, project to the caudal nucleus of the solitary tract (NTS), and synthesize mechanosensitive ion channels, Piezo-1/-2 To evaluate the functionality of NGAT1aR , we directed the fluorescent calcium indicator (GCaMP6s) or the light-sensitive channelrhodopsin-2 (ChR2) to Agtr1a -containing neurons...
January 19, 2024: Journal of Neuroscience
https://read.qxmd.com/read/38230602/salt-sensitivity-risk-derived-from-nocturnal-dipping-and-24-h-heart-rate-predicts-long-term-blood-pressure-reduction-following-renal-denervation
#25
JOURNAL ARTICLE
Gianni Sesa-Ashton, Revathy Carnagarin, Janis M Nolde, Ida Muente, Rebecca Lee, Vaughan G Macefield, Tye Dawood, Yusuke Sata, Elisabeth A Lambert, Gavin W Lambert, Antony Walton, Marcio G Kiuchi, Murray D Esler, Markus P Schlaich
BACKGROUND: Renal denervation (RDN) has been consistently shown in recent sham-controlled clinical trials to reduce blood pressure (BP). Salt sensitivity is a critical factor in hypertension pathogenesis, but cumbersome to assess by gold-standard methodology. Twenty-four-hour average heart rate (HR) and mean arterial pressure (MAP) dipping, taken by ambulatory blood pressure monitoring (ABPM), stratifies patients into high, moderate, and low salt sensitivity index (SSI) risk categories...
January 11, 2024: Journal of Hypertension
https://read.qxmd.com/read/38193292/-p2x7-mediated-antigen-independent-activation-of-cd8-t-cells-promotes-salt-sensitive-hypertension
#26
JOURNAL ARTICLE
Lance N Benson, Katherine S Deck, Christoph J Mora, Yunping Guo, Tonya M Rafferty, Lin-Xi Li, Lu Huang, J Tucker Andrews, Zhiqian Qin, Daniel W Trott, Robert S Hoover, Yunmeng Liu, Shengyu Mu
BACKGROUND: CD8+ T cells (CD8Ts) have been implicated in hypertension. However, the specific mechanisms are not fully understood. In this study, we explore the contribution of the P2X7 (purinergic receptor P2X7) receptor to CD8T activation and subsequent promotion of sodium retention in the kidney. METHODS: We used mouse models of hypertension. Wild type were used as genetic controls, OT1 and Rag2/OT1 mice were utilized to determine antigen dependency, and P2X7-knockout mice were studied to define the role of P2X7 in activating CD8Ts and promoting hypertension...
January 9, 2024: Hypertension
https://read.qxmd.com/read/38189082/canagliflozin-attenuates-kidney-injury-gut-derived-toxins-and-gut-microbiota-imbalance-in-high-salt-diet-fed-dahl-salt-sensitive-rats
#27
JOURNAL ARTICLE
Lili He, Qingjuan Zuo, Sai Ma, Guorui Zhang, Zhongli Wang, Tingting Zhang, Jianlong Zhai, Yifang Guo
PURPOSE: To investigate the effects of canagliflozin (20 mg/kg) on Dahl salt-sensitive (DSS) rat gut microbiota and salt-sensitive hypertension-induced kidney injury and further explore its possible mechanism. METHODS: Rats were fed a high-salt diet to induce hypertension and kidney injury, and physical and physiological indicators were measured afterwards. This study employed 16S rRNA sequencing technology and liquid chromatography-tandem mass spectrometry (LC-MS/MS)-based metabolic profiling combined with advanced differential and association analyses to investigate the correlation between the microbiome and the metabolome in male DSS rats...
December 2024: Renal Failure
https://read.qxmd.com/read/38187558/profiling-cellular-heterogeneity-and-fructose-transporter-expression-in-the-rat-nephron-by-integrating-single-cell-and-microdissected-tubule-segment-transcriptomes
#28
Ronghao Zhang, Darshan Aatmaram Jadhav, Benjamin Kramer, Agustin Gonzalez-Vicente
Single-cell RNA sequencing (scRNAseq) is a crucial tool in kidney research. These technologies cluster cells according to transcriptome similarity, irrespective of the anatomical location and ordering within the nephron. Thus, a cluster transcriptome may obscure heterogeneity of the cell population within a nephron segment. Elevated dietary fructose leads to salt-sensitive hypertension, in part by fructose reabsorption in the proximal tubule (PT). However, organization of the four known fructose transporters in apical PTs (SGLT4, SGLT5, GLUT5 and NaGLT1) remains poorly understood...
December 22, 2023: bioRxiv
https://read.qxmd.com/read/38180118/dendritic-cell-epithelial-sodium-channel-induced-inflammation-and-salt-sensitive-hypertension
#29
JOURNAL ARTICLE
Mert Demirci, Antentor Hinton, Annet Kirabo
PURPOSE OF REVIEW: Salt sensitivity of blood pressure (SSBP) is an independent risk factor for cardiovascular disease. Epithelial sodium channel (ENaC) plays a critical role in renal electrolyte and volume regulation and has been implicated in the pathogenesis of SSBP. This review describes recent advances regarding the role of ENaC-dependent inflammation in the development of SSBP. RECENT FINDINGS: We recently found that sodium enters dendritic cells via ENaC, a process regulated by serum/glucocorticoid-regulated kinase 1 and epoxyeicosatrienoic acid 14,15...
January 8, 2024: Current Opinion in Nephrology and Hypertension
https://read.qxmd.com/read/38174563/vascular-inflammation-and-smooth-muscle-contractility-the-role-of-nox1-derived-superoxide-and-lrrc8-anion-channels
#30
REVIEW
Fred S Lamb, Hyehun Choi, Michael R Miller, Ryan J Stark
Vascular inflammation underlies the development of hypertension, and the mechanisms by which it increases blood pressure remain the topic of intense investigation. Proinflammatory factors including glucose, salt, vasoconstrictors, cytokines, wall stress, and growth factors enhance contractility and impair relaxation of vascular smooth muscle cells. These pathways share a dependence upon redox signaling, and excessive activation promotes oxidative stress that promotes vascular aging. vascular smooth muscle cell phenotypic switching and migration into the intima contribute to atherosclerosis, while hypercontractility increases systemic vascular resistance and vasospasm that can trigger ischemia...
January 4, 2024: Hypertension
https://read.qxmd.com/read/38169288/sacubitril-valsartan-lcz696-in-the-treatment-of-systemic-hypertension-an-updated-review-of-neprilysin-inhibition-combined-with-angiotensin-ii-receptor-blockade
#31
JOURNAL ARTICLE
Miriam E Katz, William H Frishman, Wilbert S Aronow
Sacubitril-valsartan (LCZ696) has been demonstrated to be a highly effective treatment for heart failure with preserved ejection fraction since its Food and Drug Administration approval in 2015, and a growing body of evidence suggests its emergence as a hypertensive medication. It acts as an inhibitor of both neprilysin and the renin-angiotensin-aldosterone system, approaching the control of a multi-faceted pathology in multiple unique ways. Because 48% of US adults are affected by hypertension, with less than half of patients achieving controlled blood pressure, and the high correlation between uncontrolled hypertension and cardiovascular mortality, it is crucial to investigate new pharmacotherapies for managing this disease...
January 3, 2024: Cardiology in Review
https://read.qxmd.com/read/38164755/kdm6a-demethylase-regulates-renal-sodium-excretion-and-blood-pressure
#32
JOURNAL ARTICLE
Xiaobin Han, Leah Akinseye, Zhongjie Sun
BACKGROUND: KDM6A is a specific demethylase for histone 3 lysine (K) 27 trimethylation (H3K27me3). The purpose of this study is to investigate whether KDM6A in renal tubule cells plays a role in the regulation of kidney function and blood pressure. METHODS: We first crossed Ksp-Cre +/ - and KDM6A flox/flox mice for generating inducible kidney-specific deletion of KDM6A gene. RESULTS: Notably, conditional knockout of KDM6A gene in renal tubule cells (KDM6A-cKO) increased H3K27me3 levels which leads to a decrease in Na excretion and elevation of blood pressure...
January 2, 2024: Hypertension
https://read.qxmd.com/read/38164753/recent-advances-in-understanding-peripheral-and-gut-immune-cell-mediated-salt-sensitive-hypertension-and-nephropathy
#33
REVIEW
Mohammad Saleem, Sepiso K Masenga, Jeanne A Ishimwe, Mert Demirci, Taseer Ahmad, Sydney Jamison, Claude F Albritton, Naome Mwesigwa, Alexandria Porcia Haynes, Jalyn White, Kit Neikirk, Zer Vue, Antentor Hinton, Suha Arshad, Selam Desta, Annet Kirabo
Hypertension is the primary modifiable risk factor for cardiovascular, renal, and cerebrovascular diseases and is considered the main contributing factor to morbidity and mortality worldwide. Approximately 50% of hypertensive and 25% of normotensive people exhibit salt sensitivity of blood pressure, which is an independent risk factor for cardiovascular disease. Human and animal studies demonstrate that the immune system plays an important role in the etiology and pathogenesis of salt sensitivity of blood pressure, kidney damage, and vascular diseases...
January 2, 2024: Hypertension
https://read.qxmd.com/read/38126623/management-of-nocturnal-hypertension-an-expert-consensus-document-from-chinese-hypertension-league
#34
JOURNAL ARTICLE
Jing Liu, Yan Li, Xinjun Zhang, Peili Bu, Xueping Du, Lizheng Fang, Yingqing Feng, Yifang Guo, Fei Han, Yinong Jiang, Yuming Li, Jinxiu Lin, Min Liu, Wei Liu, Mingzhi Long, Jianjun Mu, Ningling Sun, Hao Wu, Jianhong Xie, Jingyuan Xie, Liangdi Xie, Jing Yu, Hong Yuan, Yan Zha, Yuqing Zhang, Shanzhu Zhu, Jiguang Wang
Nocturnal hypertension is highly prevalent among Chinese and Asian populations, which is mainly attributed to high salt intake and high salt sensitivity. Nocturnal hypertension increases the risk of cardiovascular and all-cause mortality, independent of daytime blood pressure (BP). However, it can usually be detected by 24-h ambulatory BP monitoring, rather than routine office or home BP measurement, thus is often underdiagnosed in clinical practice. Currently, no specific guidance is available for the management of nocturnal hypertension in China or worldwide...
December 21, 2023: Journal of Clinical Hypertension
https://read.qxmd.com/read/38059297/angiotensin-ii-stimulated-proximal-nephron-superoxide-production-and-fructose-induced-salt-sensitive-hypertension
#35
JOURNAL ARTICLE
Beau R Forester, Autumn Brostek, Brett Schuhler, Agustin Gonzalez-Vicente, Jeffrey L Garvin
Angiotensin II (Ang II) increases proximal tubule superoxide (O2 - ) production more in rats fed a 20% fructose normal-salt diet compared to rats fed a 20% glucose normal-salt diet. A 20% fructose high-salt diet (FHS) increases systolic blood pressure (SBP), whereas 20% glucose high-salt (GHS) doesn't. However, it is unclear whether FHS enhances Ang II induced oxidative stress in proximal tubules, and whether this contributes to increases in BP in this model. We hypothesized that FHS augments the ability of Ang II to stimulate superoxide production by proximal tubules, and this contributes to fructose-induced salt-sensitive hypertension...
December 7, 2023: American Journal of Physiology. Renal Physiology
https://read.qxmd.com/read/38056241/inhibiting-the-mapk-pathway-improves-heart-failure-with-preserved-ejection-fraction-induced-by-salt-sensitive-hypertension
#36
JOURNAL ARTICLE
Shicheng Li, Ying Shi, Shanshan Yuan, Jiangwen Ruan, Honglian Pan, Mengxiao Ma, Guoxiu Huang, Qingwei Ji, You Zhong, Tongmeng Jiang
Heart failure (HF) preserved ejection fraction (HFpEF) accounts for almost 50% of HF, and hypertension is one of the pathogenies. The MAPK signaling pathway is closely linked to heart failure and hypertension; however, its function in HEpEF resulting from salt-sensitive hypertension is not well understood. In this work, a salt-sensitive hypertension-induced HEpEF model was established based on deoxycorticosterone acetate-salt (DOCA-salt) hypertension mice. The impact of the MAPK inhibitor (Doramapimod) on HEpEF induced by salt-sensitive hypertension was assessed through various measures, such as blood pressure, transthoracic echocardiography, running distance, and histological analysis, to determine its therapeutic effectiveness on cardiac function...
December 5, 2023: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/38049579/meningeal-interleukin-17-producing-t-cells-mediate-cognitive-impairment-in-a-mouse-model-of-salt-sensitive-hypertension
#37
JOURNAL ARTICLE
Monica M Santisteban, Samantha Schaeffer, Antoine Anfray, Giuseppe Faraco, David Brea, Gang Wang, Melissa J Sobanko, Rose Sciortino, Gianfranco Racchumi, Ari Waisman, Laibaik Park, Josef Anrather, Costantino Iadecola
Hypertension (HTN), a disease afflicting over one billion individuals worldwide, is a leading cause of cognitive impairment, the mechanisms of which remain poorly understood. In the present study, in a mouse model of HTN, we find that the neurovascular and cognitive dysfunction depends on interleukin (IL)-17, a cytokine elevated in individuals with HTN. However, neither circulating IL-17 nor brain angiotensin signaling can account for the dysfunction. Rather, IL-17 produced by T cells in the dura mater is the mediator released in the cerebrospinal fluid and activating IL-17 receptors on border-associated macrophages (BAMs)...
December 4, 2023: Nature Neuroscience
https://read.qxmd.com/read/38045685/single-cell-transcriptome-analyses-reveal-the-roles-of-b-cells-in-fructose-induced-hypertension
#38
JOURNAL ARTICLE
Cheong-Wun Kim, Sung Yong Joo, Boa Kim, Jee Young Kim, Sungmin Jang, Shiang-Jong Tzeng, Sang Jin Lee, Myunghoo Kim, Inkyeom Kim
RATIONALE: While the immune system plays a crucial role in the development of hypertension, the specific contributions of distinct immune cell populations remain incompletely understood. The emergence of single-cell RNA-sequencing (scRNA-seq) technology enables us to analyze the transcriptomes of individual immune cells and to assess the significance of each immune cell type in hypertension development. OBJECTIVE: We aimed to investigate the hypothesis that B cells play a crucial role in the development of fructose-induced hypertension...
2023: Frontiers in Immunology
https://read.qxmd.com/read/38018471/striatin-gene-variants-are-associated-with-salt-sensitivity-of-blood-pressure-by-mechanisms-that-differ-in-women-and-men
#39
JOURNAL ARTICLE
Shadi K Gholami, Mahyar Heydarpour, Jonathan S Williams, Luminita H Pojoga, Gail K Adler, Gordon H Williams, Jose R Romero
BACKGROUND: Salt sensitivity of blood pressure (SSBP) is a substantial risk factor for cardiovascular morbidity and mortality. STRN (striatin) is critical for estrogen and aldosterone nongenomic signaling. However, the role of biological sex on the SSBP phenotype associated with STRN gene variants remains unexplored. METHOD: Data from 1306 subjects participating in the Hypertensive Pathotype (HyperPATH) Consortium were used to identify STRN gene single-nucleotide variants associated with SSBP...
November 29, 2023: Hypertension
https://read.qxmd.com/read/38014420/hypoxia-inducible-factor-prolyl-hydroxylase-inhibitor-roxadustat-fg-4592-reduces-renal-fibrosis-in-dahl-salt-sensitive-rats
#40
JOURNAL ARTICLE
Yoshiro Naito, Seiki Yasumura, Keisuke Okuno, Masanori Asakura, Takeshi Tsujino, Tohru Masuyama, Masaharu Ishihara
OBJECTIVE: Although hypoxia-inducible factor-prolyl hydroxylase (HIF-PH) inhibitors have been developed for the treatment of renal anemia, their effects on cardiac and renal dysfunction remain unknown. We previously reported on Dahl salt-sensitive rats, in a rat model of salt-sensitive hypertension, that exhibited anemia and impaired expression of duodenal iron transporters after the development of hypertensive cardiac and renal dysfunction. Therefore, we investigated the effects of Roxadustat (FG-4592), an HIF-PH inhibitor, on anemia, iron regulation, and cardiac and renal dysfunction in Dahl salt-sensitive rats...
November 28, 2023: Journal of Hypertension
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