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Salt sensitive hypertension

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https://www.readbyqxmd.com/read/29650676/sodium-bicarbonate-loading-limits-tubular-cast-formation-independent-of-glomerular-injury-and-proteinuria-in-dahl-salt-sensitive-rats
#1
S C Ray, B Patel, D L Irsik, J Sun, H Ocasio, G R Crislip, C H Jin, J K Chen, B Baban, A J Polichnowski, P M O'Connor
Sodium bicarbonate (NaHCO3 ) slows the decline in kidney function in patients with chronic kidney disease (CKD), yet the mechanisms mediating this effect remain unclear. The Dahl salt-sensitive (SS) rat develops hypertension and progressive renal injury when fed a high salt diet; however, the effect of alkali loading on kidney injury has never been investigated in this model. We hypothesized that 'NaHCO3 protects from the development of renal injury in Dahl salt-sensitive rats via luminal alkalization which limits the formation of tubular casts, which are a prominent pathological feature in this model...
April 12, 2018: Clinical Science (1979-)
https://www.readbyqxmd.com/read/29643251/pharmacological-characterization-of-iw-1973-a-novel-soluble-guanylate-cyclase-stimulator-with-extensive-tissue-distribution-anti-hypertensive-anti-inflammatory-and-anti-fibrotic-effects-in-preclinical-models-of-disease
#2
Jenny V Tobin, Daniel P Zimmer, Courtney Shea, Peter Germano, Sylvie G Bernier, Guang Liu, Kim Long, Joy Miyashiro, Sheila Ranganath, Sarah Jacobson, Kim Tang, G-Yoon Jamie Im, James Sheppeck, Joel D Moore, Kristine Sykes, James Wakefield, Renee Sarno, Ali R Banijamali, Albert T Profy, G Todd Milne, Mark G Currie, Jaime L Masferrer
Soluble guanylate cyclase (sGC), a key signal-transduction enzyme, increases the conversion of guanosine-5'-triphosphate (GTP) to cyclic guanosine-3',5'-monophosphate (cGMP) upon binding of nitric oxide (NO). Endothelial dysfunction and/or reduced NO signaling have been implicated in cardiovascular disease pathogenesis and complications of diabetes, and have been associated with other disease states and aging. sGC stimulators are small-molecule drugs that bind sGC and enhance NO-mediated cGMP signaling. The pharmacological characterization of IW-1973, a novel clinical-stage sGC stimulator, is described...
April 11, 2018: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/29620663/effects-of-a-low-salt-diet-on-isolated-systolic-hypertension-a-community-based-population-study
#3
Guo-Hong Yang, Xin Zhou, Wen-Jie Ji, Jun-Xiang Liu, Jing Sun, Rui Shi, Tie-Min Jiang, Yu-Ming Li
Evidence has shown that long-term sodium reduction can not only reduce blood pressure, but also provide cardiovascular benefits. To date, there is little evidence related to the effects of salt reduction on isolated systolic hypertension (ISH).A total of 126 hypertensive patients were divided into an ISH group (n = 51) and a non-ISH (NISH) group (n = 75). The members of each group were then randomly assigned to low sodium salt (LSSalt) or normal salt (NSalt) diets for 6 months. Their blood pressure was measured every 2 months...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29604087/uteroplacental-insufficiency-temporally-exacerbates-salt-induced-hypertension-associated-with-a-reduced-natriuretic-response-in-male-rat-offspring
#4
Linda A Gallo, Sarah L Walton, Marc Q Mazzuca, Marianne Tare, Helena C Parkington, Mary E Wlodek, Karen M Moritz
Intrauterine growth restriction increases the risk of developing chronic diseases in adulthood. Lifestyle factors, such as poor dietary choices, may elevate this risk. We determined whether being born small increases the sensitivity to a dietary salt challenge, in the context of hypertension, kidney disease and arterial stiffness. Bilateral uterine vessel ligation or sham surgery (offspring termed Restricted and Control, respectively) was performed on 18-day pregnant WKY rats. Male offspring were allocated to receive a diet high in salt (8% sodium chloride) or remain on standard rat chow (0...
March 31, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29602296/transcriptomic-analysis-reveals-inflammatory-and-metabolic-pathways-which-are-regulated-by-renal-perfusion-pressure-in-the-outer-medulla-of-dahl-s-rats
#5
Louise C Evans, Alex Dayton, Chun Yang, Pengyuan Liu, Theresa Kurth, Kwang Woo Ahn, Steve Komas, Francesco C Stingo, Purushottam W Laud, Marina Vannucci, Mingyu Liang, Allen W Cowley
Studies exploring the development of hypertension have traditionally been unable to distinguish which of the observed changes are underlying causes from those which are a consequence of elevated blood pressure. In this study, a custom designed servo-control system was utilized to precisely control renal perfusion pressure to the left kidney continuously during the development of hypertension in Dahl salt-sensitive rats. In this way, we maintained the left kidney at control blood pressure while the right kidney was exposed to hypertensive pressures...
March 30, 2018: Physiological Genomics
https://www.readbyqxmd.com/read/29600538/sb-216763-a-gsk-3%C3%AE-inhibitor-protects-against-aldosterone-induced-cardiac-and-renal-injury-by-activating-autophagy
#6
Yi-De Zhang, Xiao-Jun Ding, Hou-Yong Dai, Wei-Sheng Peng, Nai-Feng Guo, Yuan Zhang, Qiao-Ling Zhou, Xiao-Lan Chen
Cardiovascular and renal inflammation induced by Aldosterone (Aldo) plays a pivotal role in the pathogenesis of hypertension and renal fibrosis. GSK-3β contributes to inflammatory cardiovascular and renal diseases, but its role in Aldo-induced hypertension, and renal damage is not clear. In the present study, rats were treated with Aldo combined with SB-216763 (a GSK-3β inhibitor) for 4 weeks. Hemodynamic, cardiac, and renal parameters were assayed at the indicated time. Here we found that rats treated with Aldo presented cardiac and renal hypertrophy and dysfunction...
March 30, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29595916/the-complement-system-in-hypertension-and-renal-damage-in-the-dahl-ss-rat
#7
Jean F Regal, Connor F Laule, Luke McCutcheon, Kate M Root, Hayley Lund, Shireen Hashmat, David L Mattson
Evidence indicates the immune system is important in development of hypertension and kidney disease. In the Dahl Salt-Sensitive (SS) rat model, lymphocytes play a role in development of hypertension and kidney damage after increased sodium intake. Recent transcriptomic analyses demonstrate upregulation of the innate immune complement system in the kidney of Dahl SS rat fed a high-salt diet, leading us to hypothesize that inhibition of complement activation would attenuate development of hypertension and kidney damage...
March 2018: Physiological Reports
https://www.readbyqxmd.com/read/29594117/erythrocyte-salt-sedimentation-assay-does-not-predict-response-to-renal-denervation
#8
Oliver Vonend, Ole Martin, Lars C Rump, Patrick Kroepil, Johannes Stegbauer
Renal denervation (RDN) has recently been shown to be effective in patients without antihypertensive medication. However, about 30% of patients do not respond to RDN, and therefore, there exists a need to find predictors of response. Individuals are either salt-sensitive (SS) or non-salt-sensitive (NSS) in terms of their blood pressure (BP) regulation. The sympathetic nervous system can influence water and salt handling. RDN reduces sympathetic drive and has an impact on salt excretion. The present study was conducted to test the influence of salt sensitivity in terms of the BP reducing effect after RDN procedure...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/29581556/salt-sensitivity-of-blood-pressure-at-age-8-years-in-children-born-preterm
#9
Charlotte A Ruys, Joost Rotteveel, Monique van de Lagemaat, Harrie N Lafeber, Martijn J J Finken
Preterm birth and low birth weight have been associated with an increased risk of hypertension; postnatal growth and dietary salt intake may contribute to these associations. In adults, the change of blood pressure (BP) in response to modifications in salt intake, i.e., salt sensitivity of BP, has been independently associated with cardiovascular disease. Little is known about salt sensitivity in children. We hypothesize that it may partly explain the association between preterm birth and higher BP in later life...
March 27, 2018: Journal of Human Hypertension
https://www.readbyqxmd.com/read/29570433/targeted-disruption-of-regulated-endocrine-specific-protein-resp18-in-dahl-ss-mcw-rats-aggravates-salt-induced-hypertension-and-renal-injury
#10
Sivarajan Kumarasamy, Harshal Waghulde, Xi Cheng, Steven T Haller, Blair Mell, Basrur Abhijith, Usman M Ashraf, Ealla Atari, Bina Joe
Hypertension is a classic example of a complex polygenic trait, impacted by quantitative trait loci (QTL) containing candidate genes thought to be responsible for blood pressure (BP) control in mammals. One such mapped locus is on rat chromosome 9, wherein the proof for a positional candidate gene, Regulated Endocrine Specific Protein-18 (Resp18) is currently inadequate. To ascertain the status of Resp18 as a BP QTL, a custom targeted gene disruption model of Resp18 was developed on the Dahl Salt-Sensitive (SS) background...
March 23, 2018: Physiological Genomics
https://www.readbyqxmd.com/read/29567533/high-salt-diet-induces-metabolic-alterations-in-multiple-biological-processes-of-dahl-salt-sensitive-rats
#11
Yanjun Wang, Xiangyang Liu, Chen Zhang, Zhengjun Wang
High salt induced renal disease is a condition resulting from the interactions of genetic and dietary factors causing multiple complications. To understand the metabolic alterations associated with renal disease, we comprehensively analyzed the metabonomic changes induced by high salt intake in Dahl salt-sensitive (SS) rats using GC-MS technology and biochemical analyses. Physiological features, serum chemistry, and histopathological data were obtained as complementary information. Our results showed that high salt (HS) intake for 16 weeks caused significant metabolic alterations in both the renal medulla and cortex involving a variety pathways involved in the metabolism of organic acids, amino acids, fatty acids, and purines...
February 2, 2018: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29558753/stimulation-of-intestinal-cl-secretion-through-cftr-by-caffeine-intake-in-salt-sensitive-hypertensive-rats
#12
Xiao Wei, Zongshi Lu, Tao Yang, Peng Gao, Sijiao Chen, Daoyan Liu, Zhiming Zhu
BACKGROUND/AIMS: High salt consumption is a major risk factor for hypertension, and sodium homeostasis is regulated by both intestinal sodium absorption and urinary sodium excretion. Chronic caffeine intake has been reported to attenuate salt-sensitive hypertension by promoting urinary sodium excretion; however, its exact role in intestinal sodium absorption remains unknown. Here, we investigated whether and how chronic caffeine consumption antagonizes salt-sensitive hypertension by inhibiting intestinal sodium absorption...
March 16, 2018: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29556499/-in-silico-analysis-of-differential-gene-expression-in-three-common-rat-models-of-diastolic-dysfunction
#13
Raffaele Altara, Fouad A Zouein, Rita Dias Brandão, Saeed N Bajestani, Alessandro Cataliotti, George W Booz
Standard therapies for heart failure with preserved ejection fraction (HFpEF) have been unsuccessful, demonstrating that the contribution of the underlying diastolic dysfunction pathophysiology differs from that of systolic dysfunction in heart failure and currently is far from being understood. Complicating the investigation of HFpEF is the contribution of several comorbidities. Here, we selected three established rat models of diastolic dysfunction defined by three major risk factors associated with HFpEF and researched their commonalities and differences...
2018: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29556335/urinary-metabolites-associated-with-blood-pressure-on-a-low-or-high-sodium-diet
#14
Yuan Cheng, Haiying Song, Xiaoqing Pan, Hong Xue, Yifei Wan, Tao Wang, Zhongmin Tian, Entai Hou, Ian R Lanza, Pengyuan Liu, Yong Liu, Purushottam W Laud, Kristie Usa, Yongcheng He, Mingyu Liang
Dietary salt intake has significant effects on arterial blood pressure and the development of hypertension. Mechanisms underlying salt-dependent changes in blood pressure remain poorly understood, and it is difficult to assess blood pressure salt-sensitivity clinically. Methods: We examined urinary levels of metabolites in 103 participants of the Dietary Approaches to Stop Hypertension (DASH)-Sodium trial after nearly 30 days on a defined diet containing high sodium (targeting 150 mmol sodium intake per day) or low sodium (50 mmol per day)...
2018: Theranostics
https://www.readbyqxmd.com/read/29547880/the-influence-of-sodium-and-potassium-intake-and-insulin-resistance-on-blood-pressure-in-normotensive-individuals-is-more-evident-in-women
#15
Satoshi Murao, Yasunori Takata, Mitsugi Yasuda, Haruhiko Osawa, Fumikazu Kohi
Background: Considering sex differences, salt sensitivity and insulin resistance (IR), the effect of sodium restriction and increased potassium intake on blood pressure remains unclear in normotensive Asian individuals, compared to that in hypertensive patients. Methods: To assess the influence of sodium and potassium intake in normotensive individuals, we evaluated the estimated 24-hour urinary sodium and potassium excretion rate in 3,392 drug-naïve normotensive Japanese individuals (average age: 48...
March 14, 2018: American Journal of Hypertension
https://www.readbyqxmd.com/read/29545262/downregulation-of-l-type-voltage-gated-ca-2-voltage-gated-k-and-large-conductance-ca-2-activated-k-channels-in-vascular-myocytes-from-salt-loading-offspring-rats-exposed-to-prenatal-hypoxia
#16
Bailin Liu, Ruixiu Shi, Xiang Li, Yanping Liu, Xueqin Feng, Xueyi Chen, Xiaorong Fan, Yingying Zhang, Wenna Zhang, Jiaqi Tang, Xiuwen Zhou, Na Li, Xiyuan Lu, Zhice Xu
BACKGROUND: Prenatal hypoxia is suggested to be associated with increased risks of hypertension in offspring. This study tested whether prenatal hypoxia resulted in salt-sensitive offspring and its related mechanisms of vascular ion channel remodeling. METHODS AND RESULTS: Pregnant rats were housed in a normoxic (21% O2 ) or hypoxic (10.5% O2 ) chamber from gestation days 5 to 21. A subset of male offspring received a high-salt diet (8% NaCl) from 4 to 12 weeks after birth...
March 15, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29544657/functional-foods-for-augmenting-nitric-oxide-activity-and-reducing-the-risk-for-salt-induced-hypertension-and-cardiovascular-disease-in-japan
#17
REVIEW
Theodore W Kurtz, Stephen E DiCarlo, Michal Pravenec, R Curtis Morris
High salt intake is one of the major dietary determinants of hypertension and cardiovascular disease in Japan and throughout the world. Although dietary salt restriction may be of clinical benefit in salt-sensitive individuals, many individuals may not wish, or be able to, reduce their intake of salt. Thus, identification of functional foods that can help protect against mechanistic abnormalities mediating salt-induced hypertension is an issue of considerable medical and scientific interest. According to the "vasodysfunction" theory of salt-induced hypertension, the hemodynamic abnormality initiating salt-induced increases in blood pressure usually involves subnormal vasodilation and abnormally increased vascular resistance in response to increased salt intake...
March 12, 2018: Journal of Cardiology
https://www.readbyqxmd.com/read/29541444/the-development-of-salt-sensitive-hypertension-regulated-by-psgl-1-gene-in-mice
#18
Yuhui Yang, Xue Liu, Yunpeng Liu, Hui Fu, Ying Gao, Xing Liu, Xiaoliang Jiang
Background and objective: Chronic inflammatory is involved in the development of salt-sensitive hypertension and other cardiovascular diseases. PSGL-1 plays an important role in the inflammatory response. Methods and results: In this study, we used PSGL-1-/- and PSGL-1+/+ mice fed with high salt diet to measure the blood pressure, inflammatory response and vascular injury. We found that, in PSGL-1+/+ mice, high salt diet resulted in high blood pressure with the increased expression of serum inflammatory cytokines IL-6, IL-1β and TNFɑ, vascular injury markers MCP-1, ET-1, and VWF, and renal macrophages and T cells infiltration, and endothelium-dependent acetylcholine vasodilation dysfunction...
2018: Cell & Bioscience
https://www.readbyqxmd.com/read/29537860/rag1-null-dahl-ss-rats-reveal-adaptive-immune-mechanisms-exacerbate-high-protein-induced-hypertension-and-renal-injury
#19
Justine M Abais-Battad, Hayley Lund, Daniel J Fehrenbach, John Henry Dasinger, David L Mattson
The current study, performed in Dahl Salt-Sensitive (SS) and SS-Rag1-/- rats lacking T- and B- lymphocytes, tested the hypothesis that immune cells amplify salt-sensitive hypertension and kidney damage in response to a high protein diet. After weaning, SS and SS-Rag1-/- rats were placed on an isocaloric, 0.4% NaCl diet containing normal (18%) or high (30%) protein. At 9 weeks of age, rats were switched to a 4.0% NaCl diet containing the same amount of dietary protein and maintained on the high salt diet for 3 weeks...
March 14, 2018: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/29521003/daily-sodium-intake-influences-the-relationship-between-angiotensin-converting-enzyme-gene-insertion-deletion-polymorphism-and-hypertension-in-older-adults
#20
Ivna V Freire, Cezar A Casotti, Ícaro J S Ribeiro, Jonas R D Silva, Ana A L Barbosa, Rafael Pereira
The angiotensin-converting enzyme insertion/deletion (I/D) gene polymorphism has been widely reported as being associated with hypertension; however, most studies do not consider environmental/behavioral factors. This study aimed to investigate the relationship among angiotensin-converting enzyme insertion/deletion gene polymorphism, environmental/behavioral factors, and hypertension in community-dwelling elderly individuals. All community-dwelling older adults from Aiquara, Bahia, Brazil, were invited to take part in this study...
March 2018: Journal of Clinical Hypertension
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