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Salt sensitive hypertension

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https://www.readbyqxmd.com/read/29050005/effect-of-salt-intake-on-serum-glucagon-like-peptide-1-levels-in-normotensive-salt-sensitive-subjects
#1
Wen-Ling Zheng, Chao Chu, Yong-Bo Lv, Yang Wang, Jia-Wen Hu, Qiong Ma, Yu Yan, Yu-Meng Cao, Xi-Long Dang, Ke-Ke Wang, Jian-Jun Mu
BACKGROUND/AIMS: Excess dietary salt is a critical risk factor of salt-sensitive hypertension. Glucagon-like peptide-1 (GLP-1) , a gut incretin hormone, conferring benefits for blood pressure by natriuresis and diuresis. We implemented a randomized trial to verify the effect of altered salt intake on serum GLP-1 level in human beings. METHODS: The 38 subjects were recruited from a rural community of Northern China. All subjects were sequentially maintained a baseline diet period for 3 days, a low-salt diet period for 7 days (3...
October 19, 2017: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29045522/molecular-genetics-of-salt-sensitivity-and-hypertension-role-of-renal-epithelial-sodium-channel-genes
#2
Silvia R S Freitas
No abstract text is available yet for this article.
October 13, 2017: American Journal of Hypertension
https://www.readbyqxmd.com/read/29038288/ets-in-the-kidney-unraveling-the-molecular-mechanism-underlying-renal-damage-in-salt-sensitive-hypertension
#3
EDITORIAL
Joseph C Gigliotti, Thu H Le
No abstract text is available yet for this article.
October 16, 2017: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/29038201/kinin-b1-receptor-promotes-neurogenic-hypertension-through-activation-of-centrally-mediated-mechanisms
#4
Srinivas Sriramula, Eric Lazartigues
Hypertension is associated with increased activity of the kallikrein-kinin system. Kinin B1 receptor (B1R) activation leads to vasoconstriction and inflammation. Despite evidence supporting a role for the B1R in blood pressure regulation, the mechanisms by which B1R could alter autonomic function and participate in the pathogenesis of hypertension remain unidentified. We sought to explore whether B1R-mediated inflammation contributes to hypertension and investigate the molecular mechanisms involved. In this study, we tested the hypothesis that activation of B1R in the brain is involved in the pathogenesis of hypertension, using the deoxycorticosterone acetate-salt model of neurogenic hypertension in wild-type and B1R knockout mice...
October 16, 2017: Hypertension
https://www.readbyqxmd.com/read/29021382/sustained-activation-of-guanylate-cyclase-a-with-tdt-a-natriuretic-peptide-derivative-exhibits-cardiorenal-protection-in-dahl-salt-sensitive-hypertensive-rats
#5
Shohei Oishi, Naoko Suzuki, Yuri Hasui, Tsuyoshi Homma, Masanori Obana, Takahiro Nagayama, Yasushi Fujio
Heart failure often presents with prognosis-relevant impaired renal function. To investigate whether the chronic activation of guanylate cyclase-A (GC-A) protects both heart and kidney, we examined the effects of TDT, a neprilysin (NEP)-resistant natriuretic peptide (NP) derivative, on cardiac and renal dysfunction in Dahl salt-sensitive hypertensive rats (DS rats). Pretreatment with NEP or NEP inhibitor did not influence GC-A activation by TDT both in vitro and in vivo, resulting in a long-acting profile of TDT compared to native human atrial NP (hANP)...
October 11, 2017: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/28993450/blood-pressure-genetic-risk-score-predicts-blood-pressure-responses-to-dietary-sodium-and-potassium-the-gensalt-study-genetic-epidemiology-network-of-salt-sensitivity
#6
Jovia L Nierenberg, Changwei Li, Jiang He, Dongfeng Gu, Jichun Chen, Xiangfeng Lu, Jianxin Li, Xigui Wu, C Charles Gu, James E Hixson, Dabeeru C Rao, Tanika N Kelly
We examined the association between genetic risk score (GRS) for blood pressure (BP), based on single nucleotide polymorphisms identified in previous BP genome-wide association study meta-analyses, and salt and potassium sensitivity of BP among participants of the GenSalt study (Genetic Epidemiology Network of Salt Sensitivity). The GenSalt study was conducted among 1906 participants who underwent a 7-day low-sodium (51.3 mmol sodium/d), 7-day high-sodium (307.8 mmol sodium/d), and 7-day high-sodium plus potassium (60 mmol potassium/d) intervention...
October 9, 2017: Hypertension
https://www.readbyqxmd.com/read/28985281/striatin-gene-polymorphic-variants-are-associated-with-salt-sensitive-blood-pressure-in-normotensives-and-hypertensives
#7
Tina Gupta, Molly Connors, Jia Wei Tan, Worapaka Manosroi, Noha Ahmed, Pei Yee Ting, Amanda E Garza, Jose R Romero, Paul N Hopkins, Jonathan S Williams, Gordon H Williams
BACKGROUND: Understanding the interactions between genetics, sodium (Na+) intake, and blood pressure (BP) will help overcome the lack of individual specificity in our current treatment of hypertension. This study had 3 goals: expand on the relationship between striatin gene (STRN) status and salt-sensitivity of BP (SSBP); evaluate the status of Na+ and volume regulating systems by striatin risk allele status; evaluate potential SSBP mechanisms. METHODS: We assessed the relationship between STRN status in humans (HyperPATH cohort) and SSBP and on volume regulated systems in humans and a striatin knockout mouse (STRN+/-)...
September 13, 2017: American Journal of Hypertension
https://www.readbyqxmd.com/read/28978980/role-of-bardoxolone-methyl-a-nuclear-factor-erythroid-2-related-factor-2-activator-in-aldosterone-and-salt-induced-renal-injury
#8
Mikako Hisamichi, Atsuko Kamijo-Ikemori, Takeshi Sugaya, Seiko Hoshino, Kenjiro Kimura, Yugo Shibagaki
The aim of this study was to investigate the renoprotective effect of bardoxolone methyl (BM), a nuclear factor erythroid 2-related factor 2 (Nrf2) activator with an antioxidant effect, in a salt-sensitive hypertension model induced by aldosterone (Ald) and salt. Tubulointerstitial damage with urinary liver-type fatty acid-binding protein (L-FABP) was evaluated using human L-FABP chromosomal transgenic (L-FABP(+/-)) male mice. The mice in the Ald group (n=7) received systemic Ald infusions via an osmotic minipump and were given 1% NaCl water for 35 days...
October 5, 2017: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/28978533/non-invasive-measurement-of-renal-blood-flow-by-magnetic-resonance-imaging-mri-in-rats
#9
Cesar A Romero, Glauber Cabral, Robert A Knight, Guangliang Ding, Edward L Peterson, Oscar A Carretero
Renal blood flow (RBF) provides important information regarding renal physiology and nephropathies. Arterial spin labeling-magnetic resonance imaging (ASL-MRI) is a non-invasive method of measuring blood flow without exogenous contrast media. However, low signal/noise ratio and respiratory motion artifacts are challenges for RBF measurements in small animals. Our objective was to evaluate the feasibility and reproducibility of RBF measures by ASL-MRI using respiratory-gating and navigator correction methods to reduce motion artifacts...
October 4, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28968260/central-antihypertensive-effects-of-chronic-treatment-with-rb150-an-orally-active-aminopeptidase-a-inhibitor-in-deoxycorticosterone-acetate-salt-rats
#10
Yannick Marc, Reda Hmazzou, Fabrice Balavoine, Adrien Flahault, Catherine Llorens-Cortes
BACKGROUND AND OBJECTIVE: Hyperactivity of the brain renin-angiotensin (Ang) system has been implicated in the development and maintenance of hypertension. AngIII, one of the main effector peptides of the brain renin-Ang system, exerts a tonic stimulatory control over blood pressure (BP) in hypertensive rats. Aminopeptidase A (APA), the enzyme generating brain AngIII, represents a new therapeutic target for the treatment of hypertension. We developed RB150, a prodrug of the specific and selective APA inhibitor, EC33...
September 28, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28960144/blood-pressure-regulation-reviewing-evidence-for-interplay-between-common-dietary-sugars-and-table-salt
#11
Harry G Preuss, Dallas Clouatre, Anand Swaroop, Manashi Bagchi, Debasis Bagchi, Gilbert R Kaats
A popular concept is that the significant global progression in prevalence and intensification of elevated blood pressure (BP) levels is due in part to dietary indiscretions. Excess intake of several food sources causing overweight/obesity plays an important role in BP perturbations. However, certain nutrients are involved in ways other than via body fat accumulation, particularly table salt (sodium chloride) and popular refined carbohydrates like dietary sugars (sucrose, fructose, high fructose corn syrup)...
September 29, 2017: Journal of the American College of Nutrition
https://www.readbyqxmd.com/read/28940950/rosuvastatin-pretreatment-suppresses-distant-organ-injury-following-unilateral-renal-ischemia-reperfusion-in-hypertensive-dahl-salt-sensitive-rats
#12
Makoto Kanno, Masaaki Nakayama, Wan-Jun Zhu, Yoshimitsu Hayashi, Junichiro James Kazama
AIM: Ischemia-reperfusion (I/R) induces distant organ injury (DOI) via inflammation and oxidative stress. Statins have anti-inflammatory and anti-oxidant effects independent of their cholesterol-lowering properties. To clarify whether statins could suppress DOI, we investigated the effect of rosuvastatin (RO) on the contralateral kidney following unilateral renal I/R. METHODS: Dahl salt-sensitive rats (6-week-old) were randomly divided into four groups: sham, sham with RO, I/R, and I/R with RO...
September 22, 2017: Nephrology
https://www.readbyqxmd.com/read/28938457/the-association-of-estrogen-receptor-%C3%AE-gene-variation-with-salt-sensitive-blood-pressure
#13
Worapaka Manosroi, Jia Wei Tan, Chevon M Rariy, Bei Sun, Mark O Goodarzi, Aditi R Saxena, Jonathan S Williams, Luminita H Pojoga, Jessica Lasky-Su, Jinrui Cui, Xiuqing Guo, Kent D Taylor, Yii-Der I Chen, Anny H Xiang, Willa A Hsueh, Leslie J Raffel, Thomas A Buchanan, Jerome I Rotter, Gordon H Williams, Ellen W Seely
Context: Hypertension in young women is uncommon compared to young men and older women. Estrogen appears to protect most women against hypertension with incidence increasing after menopause. Since some premenopausal women develop hypertension, estrogen may play a different role in these women. Genetic variations in the estrogen receptor (ER) are associated with cardiovascular disease. ER-β, encoded by ESR2, is the ER predominantly expressed in vascular smooth muscle. Objective: To determine an association of single nucleotide polymorphisms (SNPs) in ESR2 with salt-sensitivity of blood pressure (SSBP) and estrogen status in women...
September 5, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28938454/11%C3%AE-hsd2-sumoylation-modulates-cortisol-induced-mineralocorticoid-receptor-nuclear-translocation-independently-of-effects-on-transactivation
#14
Rubén Jiménez-Canino, Fabián Lorenzo-Díaz, Alex Odermatt, Matthew A Bailey, Dawn E W Livingstone, Frederic Jaisser, Nicolette Farman, Diego Alvarez de la Rosa
The enzyme 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2) has an essential role in aldosterone target tissues, conferring aldosterone selectivity for the mineralocorticoid receptor (MR) by converting 11β-hydroxyglucocorticoids to inactive 11-ketosteroids. Congenital deficiency of 11β-HSD2 causes a form of salt-sensitive hypertension known as the syndrome of apparent mineralocorticoid excess. The disease phenotype, which ranges from mild to severe, correlates well with reduction in enzyme activity. Furthermore, polymorphisms in the 11β-HSD2 coding gene (HSD11B2) have been linked to high blood pressure and salt-sensitivity, major cardiovascular risk factors...
September 15, 2017: Endocrinology
https://www.readbyqxmd.com/read/28931751/essential-role-of-kir5-1-channels-in-renal-salt-handling-and-blood-pressure-control
#15
Oleg Palygin, Vladislav Levchenko, Daria V Ilatovskaya, Tengis S Pavlov, Oleh M Pochynyuk, Howard J Jacob, Aron M Geurts, Matthew R Hodges, Alexander Staruschenko
Supplementing diets with high potassium helps reduce hypertension in humans. Inwardly rectifying K+ channels Kir4.1 (Kcnj10) and Kir5.1 (Kcnj16) are highly expressed in the basolateral membrane of distal renal tubules and contribute to Na+ reabsorption and K+ secretion through the direct control of transepithelial voltage. To define the importance of Kir5.1 in blood pressure control under conditions of salt-induced hypertension, we generated a Kcnj16 knockout in Dahl salt-sensitive (SS) rats (SSKcnj16-/-). SSKcnj16-/- rats exhibited hypokalemia and reduced blood pressure, and when fed a high-salt diet (4% NaCl), experienced 100% mortality within a few days triggered by salt wasting and severe hypokalemia...
September 21, 2017: JCI Insight
https://www.readbyqxmd.com/read/28929577/salt-intake-and-blood-pressure-response-to-percutaneous-renal-denervation-in-resistant-hypertension
#16
Esther de Beus, Rosa L de Jager, Martine M Beeftink, Margreet F Sanders, Wilko Spiering, Evert-Jan Vonken, Michiel Voskuil, Michiel L Bots, Peter J Blankestijn
The effect of lowering sympathetic nerve activity by renal denervation (RDN) is highly variable. With the exception of office systolic blood pressure (BP), predictors of the BP-lowering effect have not been identified. Because dietary sodium intake influences sympathetic drive, and, conversely, sympathetic activity influences salt sensitivity in hypertension, we investigated 24-hour urinary sodium excretion in participants of the SYMPATHY trial. SYMPATHY investigated RDN in patients with resistant hypertension...
September 19, 2017: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/28929450/intrarenal-angiotensin-converting-enzyme-the-old-and-the-new
#17
REVIEW
Silas Culver, Caixia Li, Helmy M Siragy
PURPOSE OF REVIEW: The intrarenal renin-angiotensin-aldosterone system (RAS) is an independent paracrine hormonal system with an increasingly prominent role in hypertension and renal disease. Two enzyme components of this system are angiotensin-converting enzyme (ACE) and more recently discovered ACE2. The purpose of this review is to describe recent discoveries regarding the roles of intrarenal ACE and ACE2 and their interaction. RECENT FINDINGS: Renal tubular ACE contributes to salt-sensitive hypertension...
September 19, 2017: Current Hypertension Reports
https://www.readbyqxmd.com/read/28922660/mitochondrial-dysfunction-and-altered-renal-metabolism-in-dahl-salt-sensitive-rats
#18
Zhengjun Wang, Qiong Sun, Na Sun, Mingyu Liang, Zhongmin Tian
BACKGROUND/AIMS: The kidney plays a critical role in the control of blood pressure and its elevation in salt-induced hypertension. Mitochondrial dysfunction, especially in energy metabolism, has been associated with hypertension. Here, we aimed to investigate mitochondrial function and metabolic features in renal mitochondria of Dahl salt-sensitive (SS) rats to gain further insight into the relationship between mitochondrial metabolism and predisposition to hypertension. METHODS: In this study, SS rats fed low-salt (LS) or high-salt (HS) diets were used to investigate mitochondrial function and metabolism including mitochondrial enzyme activities, pyridine nucleotides, metabolites, and oxidative stress by biochemical analysis and gas chromatography-mass spectrometer (GC-MS)...
2017: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/28888840/teneligliptin-prevents-cardiomyocyte-hypertrophy-fibrosis-and-development-of-hypertensive-heart-failure-in-dahl-salt-sensitive-rats
#19
Masayoshi Yamamoto, Tomoko Ishizu, Yoshihiro Seo, Yoshimi Suto, Seika Sai, Dongzhu Xu, Nobuyuki Murakoshi, Taizo Kimura, Yasushi Kawakami, Kazutaka Aonuma
BACKGROUND: We investigated the effects of the dipeptidyl peptidase 4 inhibitor teneligliptin on cardiac function and hemodynamics during heart failure in hypertensive model rats. METHODS AND RESULTS: Fifty-five male Dahl salt-sensitive rats were divided into 4 groups: control group (0.3% NaCl chow; n = 13), hypertension (HT) group (8% NaCl chow; n = 20), HT-early TNL group (8% NaCl chow and teneligliptin from 6 weeks; n = 10), and HT-late TNL group (8% NaCl chow and teneligliptin from 10 weeks; n = 12)...
September 6, 2017: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/28876684/differences-in-microbiome-in-rat-models-of-cardiovascular-disease
#20
A Thiba, C A Umar, S Myende, E Nweke, K Rumbold, G Candy
BACKGROUND: Recent studies have underscored the important role the gut metagenome in various human diseases, including diabetes and obesity. Hypertension is a major risk factor for cardiovascular disease, stroke, and heart and kidney failure, and affects approximately 25% of the world's adult population. The cause of essential hypertension remains unknown. Patients given antibiotics show blood pressure changes and transfer of gut bacteria from hypertensive to normal WKY rats resulted in the latter developing hypertension...
June 2017: South African Journal of Surgery. Suid-Afrikaanse Tydskrif Vir Chirurgie
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