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Real Time Central Assessment o...
Real Time Central Assessment of Kidney Transplant Indication Biopsies by Microarrays: The INTERCOMEX Study
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JOURNAL ARTICLE
P F Halloran, J Reeve, E Akalin, O Aubert, G A Bohmig, D Brennan, J Bromberg, G Einecke, F Eskandary, C Gosset, J-P Duong Van Huyen, G Gupta, C Lefaucheur, A Malone, R B Mannon, D Seron, J Sellares, M Weir, A Loupy
The authors conducted a prospective trial to assess the feasibility of real time central molecular assessment of kidney transplant biopsy samples from 10 North American or European centers. Biopsy samples taken 1 day to 34 years posttransplantation were stabilized in RNAlater, sent via courier overnight at ambient temperature to the central laboratory, and processed (29 h workflow) using microarrays to assess T cell- and antibody-mediated rejection (TCMR and ABMR, respectively). Of 538 biopsy samples submitted, 519 (96%) were sufficient for microarray analysis (average length, 3 mm)...
November 2017: American Journal of Transplantation
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