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Coiled Coil

Pascual Lozano-Vilardell, Raúl Lara-Hernández, Noé Benabarre-Castany, David García-García
A 79-year old patient with an asymptomatic 63-mm infrarenal abdominal aortic aneurysm, confirmed on computed tomography, was admitted in our unit. The patient had undergone kidney transplantation years before, due to renal failure secondary to polycystic kidney disease. Renal function at admission was normal. The aneurysm had a very short neck, and a standard endovascular aortic repair procedure was not feasible. So, the two renal arteries were embolized with coils and endovascular repair of the aneurysm, covering the ostia of the renal arteries, was achieved placing the endoprosthesis up to the level of superior mesenteric artery...
October 17, 2018: Annals of Vascular Surgery
Jacint G Sanchez, Konstantin M J Sparrer, Cindy Chiang, Rebecca A Reis, Jessica J Chiang, Matthew A Zurenski, Yueping Wan, Michaela U Gack, Owen Pornillos
TRIM25 is a multi-domain, RING-type E3 ubiquitin ligase of the tripartite motif family that has important roles in multiple RNA-dependent processes. In particular, TRIM25 functions as an effector of RIG-I and ZAP, which are innate immune sensors that recognize viral RNA and induce ubiquitin-dependent anti-viral response mechanisms. TRIM25 is reported to also bind RNA, but the molecular details of this interaction or its relevance to anti-viral defense have not been elucidated. Here, we characterize the RNA-binding activity of TRIM25 and find that the protein binds both single-stranded and double-stranded RNA...
October 17, 2018: Journal of Molecular Biology
Neeraj Varyanit, Cinosh Mathew, Kim J Mammen, Rajneesh Calton
Congenital renal arteriovenous malformations (AVMs) are rare benign vascular lesions and a rare cause of massive hematuria in females predominantly involving right kidney. Clinical presentation in a male with involvement of the left kidney is very rare. Only a few case series describing the outcome of congenital renal AVMs have been reported in the literature. We report a challenging case of a male patient with life threatening massive hematuria with congenital renal AVMs in left kidney. Successful embolization was performed using coils and gel foam...
March 2018: Journal of the Association of Physicians of India
Hooman Yadollahi-Farsani, Marcus Herrmann, David Frakes, Brian Chong
PURPOSE: To gain insight into the influence of coils on aneurysmal hemodynamics, computational fluid dynamics (CFD) can be used. Conventional methods of modeling coils consider the explicit geometry of the deployed devices within the aneurysm and discretize the fluid domain. However, the complex geometry of a coil mass leads to cumbersome domain discretization along with a significant number of mesh elements. These problems have motivated a homogeneous porous medium coil model, whereby the explicit geometry of the coils is greatly simplified, and relevant homogeneous porous medium parameters are approximated...
October 18, 2018: Cardiovascular Engineering and Technology
Wen-Juan Ma, Yang-Kui Gu, Jian-Hong Peng, Xue-Cen Wang, Xin Yue, Zhi-Zhong Pan, Gong Chen, Hai-Neng Xu, Zhong-Guo Zhou, Rong-Xin Zhang
Chemoradiotherapy combined with surgical resection is the standard treatment for locally advanced rectal cancer, but not all the patients respond to neoadjuvant treatment. Transforming acidic coiled-coil protein-3 (TACC3) is frequently aberrantly expressed in rectal cancer tissue. In this study, we investigated whether TACC3 could serve as a biomarker predictive of the efficacy of chemoradiotherapy. In all, 152 rectal cancer patients with tumor tissue collected at biopsy and set aside before treatment were enrolled in this study...
October 19, 2018: Aging
Sihui Luo, Lizhi Xiao, Xin Li, Guangzhi Liao, Huabing Liu, Zhengduo Wang, Zhe Sun, Wei Liu, Yangyang Xu
In low-field NMR, depth information and radial profile information of downhole formation can be easily acquired with the help of static gradient magnetic field produced by permanent magnets, called downhole NMR imaging. Based on the hypothesis that the formation is homogeneous, average signals detected by centralized or decentralized sensors can provide enough information for petrophysical parameters. In fact, the inhomogeneity of formation may have serious impact on description of the characteristics of formation and oil/gas location which is rarely studied in NMR well-logging...
October 16, 2018: Magnetic Resonance Imaging
F Proust, S Bracard, J-P Lejeune, L Thines, X Leclerc, G Penchet, J Bergé, X Morandi, J-Y Gauvrit, K Mourier, F Ricolfi, M Lonjon, J Sedat, B Bataille, J Droineau, T Civit, E Magro, I Pelissou-Guyotat, H Cebula, K Lallouche, P David, E Emery, P Courthéoux, J-R Vignes, J Bénichou, N Aghakani, P-H Roche, E Gay, P Bessou, J Guabrillargues, B Irthum
BACKGROUND: Current aging of the population with good physiological status and the increasing incidence of subarachnoid hemorrhage (SAH) in elderly patients has enhanced the benefit of treatment in terms of independence and long-term quality of life (QoL). METHODS: From November 1, 2008 to October 30, 2012, 351 patients aged 70 years or older with aneurysmal SAH underwent adapted treatment: endovascular coiling (EV) for 228 (65%) patients, microsurgical clipping (MS) for 75 (29...
October 16, 2018: Neuro-Chirurgie
Do Hoon Kim, Gwang Ha Kim, Chang Min Cho, Chang Hwan Park, Soo-Young Na, Tae Hyeon Kim, Yu Kyung Cho, Ji Hyun Kim, Dong-Wan Seo
BACKGROUND: Endoscopic ultrasonography-guided fine-needle biopsy (EUS-FNB) may facilitate tissue acquisition for a definitive diagnosis of gastrointestinal subepithelial tumors (SETs). This study aimed to determine the diagnostic yield of EUS-FNB using a novel 20-gauge ProCore needle with a coiled sheath in tissue sampling of gastrointestinal SETs. METHODS: Between July 2016 and February 2017, 39 patients with gastrointestinal SETs were prospectively recruited from six university hospitals in Korea...
October 19, 2018: BMC Gastroenterology
Jianfeng Wu, Liyan Zhang
Viscosity, pH and electrolytic conductivity of dilute, semidilute and concentrated chitosan solution with hydrochloric acid adding were compared and the change in conformation of chitosan in concentrated solution was discussed. The dissolution behavior of chitosan in concentrated chitosan hydrochloric acid solution was investigated through determination of solution turbidity, microstate and size of chitosan particle. It was found that the concentration, degree of deacetylation (DD) of chitosan and content of hydrochloric acid in solution showed significant effects on the changes in viscosity, pH, and electrolytic conductivity of chitosan solution as hydrochloric acid added...
October 16, 2018: International Journal of Biological Macromolecules
A B de Castro, Natalia Dyba, Elizabeth D Cortez, Genecar G Pe Benito
BACKGROUND: Collaborative Online International Learning (COIL) is a pedagogical approach using digital technology to provide experiential international learning without travel abroad. Through web-based, cross-country intellectual exchange, COIL helps prepare nursing students for increasingly diverse and multicultural health care work environments globally. PROBLEM: Opportunities to engage in multicultural learning experiences have traditionally relied on intensive study abroad trips, which can be prohibitive for students with limited fiscal resources or who are place-bound...
October 18, 2018: Nurse Educator
Jinpeng Han, Chenyu Liang, Yuchen Cui, Likun Xiong, Xiaocui Guo, Xiaoyan Yuan, Dayong Yang
Room-temperature storage and transportation of microorganisms maximize the power of microorganisms in healthcare, energy and environment. Recently, paper-based biotechnologies have been developed to enable room-temperature storage of a variety of non-living biosystems such as diagnostic devices and cell-free systems. Herein, room-temperature storage of living microorganisms is realized by an electrospun nonwoven paper containing convex region, which is composed of coiled microfibers with dense distribution of microorganisms...
October 19, 2018: ACS Applied Materials & Interfaces
Qingbao Guan, Li Yuan, Aijuan Gu, Guozheng Liang
Although the concept of molecular composites (MCs) is very promising, there are major obstacles arising from the immiscibility of the rigid-rod with the random-coil polymers. Here we developed a novel method for fabricating in-situ reinforced MC system with non-equilibrium self-assembled nano-fibrous structures based on bisphenol A epoxy resin, 4,4'-diaminodiphenylsulfone, bismaleimide, and polyphenylene ether (PPO) oligomer. A variety of spectroscopic and morphological techniques were used to probe the structural evolution from the emergence of nano-fibrils, to growth and aggregation of nano-fibers, and then to formation of in-situ reinforced MC with strong interfacial interaction...
October 19, 2018: ACS Applied Materials & Interfaces
Xiao Zhao, Shinobu Takao, Takuma Kaneko, Yasuhiro Iwasawa
It remains a big challenge to remarkably improve both oxygen reduction reaction (ORR) activity and long-term durability of Pt-M bimetal electrocatalysts simultaneously in the harsh cathode environment toward widespread commercialization of polymer electrolyte fuel cells (PEFC). In this account we found double-promotional effects of carbon micro coil (CMC) support on ORR performance and durability of octahedral Pt3 Ni nanoparticles (Oh Pt3 Ni/CMC). The Oh Pt3 Ni/CMC displayed remarkable improvements of mass activity (MA; 13...
October 19, 2018: Chemical Record: An Official Publication of the Chemical Society of Japan ... [et Al.]
Richard G Lee, Maryam Sedghi, Mehri Salari, Anne-Marie J Shearwood, Maike Stentenbach, Ariana Kariminejad, Hayley Goullee, Oliver Rackham, Nigel G Laing, Homa Tajsharghi, Aleksandra Filipovska
Objective: Our goal was to identify the gene(s) associated with an early-onset form of Parkinson disease (PD) and the molecular defects associated with this mutation. Methods: We combined whole-exome sequencing and functional genomics to identify the genes associated with early-onset PD. We used fluorescence microscopy, cell, and mitochondrial biology measurements to identify the molecular defects resulting from the identified mutation. Results: Here, we report an association of a homozygous variant in CHCHD2 , encoding coiled-coil-helix-coiled-coil-helix domain containing protein 2, a mitochondrial protein of unknown function, with an early-onset form of PD in a 26-year-old Caucasian woman...
October 2018: Neurology. Genetics
Margaret A Sinkler, Michael Bosley
Hepatic adenomas are rare, benign liver masses of rising incidence in the United States. We present a report of a 22-year-old asymptomatic female with a massive (14.2 × 11.4 cm), centrally located hepatic adenoma. The unique presentation of the adenoma in close proximity to the hepatic vasculature meant the patient was not a candidate for surgical resection. An arterial embolization was used as an alternative approach to initial treatment. Arterial branches supplying the adenoma were identified via computed tomography and embolized with embospheres and coils...
January 2019: Radiology Case Reports
Wan-Jung C Lai, Mohammad Kayedkhordeh, Erica V Cornell, Elie Farah, Stanislav Bellaousov, Robert Rietmeijer, Enea Salsi, David H Mathews, Dmitri N Ermolenko
The 5' and 3' termini of RNA play important roles in many cellular processes. Using Förster resonance energy transfer (FRET), we show that mRNAs and lncRNAs have an intrinsic propensity to fold in the absence of proteins into structures in which the 5' end and 3' end are ≤7 nm apart irrespective of mRNA length. Computational estimates suggest that the inherent proximity of the ends is a universal property of most mRNA and lncRNA sequences. Only guanosine-depleted RNA sequences with low sequence complexity are unstructured and exhibit end-to-end distances expected for the random coil conformation of RNA...
October 18, 2018: Nature Communications
Maureen Bardet, Thomas Seeholzer, Adeline Unterreiner, Simone Woods, Daniel Krappmann, Frédéric Bornancin
The MALT1 (Mucosa associated lymphoid tissue lymphoma translocation protein 1) paracaspase couples antigen receptors on lymphocytes to downstream signaling events. Activation of MALT1 is known to involve stimulus-dependent CBM complex formation, that is, the recruitment of BCL10-bound MALT1 to a CARD-Coiled Coil protein. Beyond this canonical, CBM-dependent mechanism of MALT1 activation, recent studies suggest that MALT1 protease activity may be triggered by alternative mechanisms. For instance, the E3-ligase TRAF6 can activate MALT1 proteolytic function and induce MALT1 auto-cleavage...
October 15, 2018: Biochemical and Biophysical Research Communications
Juliette van Dijk, Guillaume Bompard, Julien Cau, Shinji Kunishima, Gabriel Rabeharivelo, Julio Mateos-Langerak, Chantal Cazevieille, Patricia Cavelier, Brigitte Boizet-Bonhoure, Claude Delsert, Nathalie Morin
BACKGROUND: Upon maturation in the bone marrow, polyploid megakaryocytes elongate very long and thin cytoplasmic branches called proplatelets. Proplatelets enter the sinusoids blood vessels in which platelets are ultimately released. Microtubule dynamics, bundling, sliding, and coiling, drive these dramatic morphological changes whose regulation remains poorly understood. Microtubule properties are defined by tubulin isotype composition and post-translational modification patterns. It remains unknown whether microtubule post-translational modifications occur in proplatelets and if so, whether they contribute to platelet formation...
October 18, 2018: BMC Biology
Kirstan Gimse, Ryan C Gorzek, Andrew Olin, Sue Osting, Corinna Burger
Coiled-coil forms of Homer1, including Homer1b and c (Homer1b/c) have been shown to play a role in hippocampal learning and memory and synaptic plasticity. We have previously found that overexpression of hippocampal Homer1c is sufficient to rescue learning and memory ability in aged learning impaired rats and in Homer1 knockout (KO) mice, and to rescue group I metabotropic glutamate receptor (mGluR1/5) mediated long-term potentiation in KO mice. Here, to determine if Homer1b/c is necessary for successful learning and memory we have utilized a rAAV5 vector expressing a Homer1b/c-targeting short hairpin RNA to knock down the expression of hippocampal Homer1b/c in adult 4-6-month old male Sprague Dawley rats...
October 15, 2018: Neurobiology of Learning and Memory
Yang Cao, Yan Lei, Yang Luo, Tan Tan, Baochen Du, Yanbo Zheng, Le Sun, Qianjin Liang
When a cell migrates, the centrosome positions between the nucleus and the leading edge of migration via the microtubule system. The protein CrpF46 (centrosome-related protein F46) has a known role during mitosis and centrosome duplication. However, how CrpF46 efficiently regulates centrosome-related cell migration is unclear. Here, we report that knockdown of CrpF46 resulted in the disruption of microtubule arrangement, with impaired centrosomal reorientation, and slowed down cell migration. In cells that express low levels of CrpF46 , stress fibers were weakened, which could be rescued by recovering Flag-CrpF46 ...
October 15, 2018: Experimental Cell Research
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