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De Novo

Kaven Baessler, Corina Christmann-Schmid, Christopher Maher, Nir Haya, Tineke J Crawford, Julie Brown
BACKGROUND: Pelvic organ prolapse (POP) is common in women and is frequently associated with stress urinary incontinence (SUI). In many cases however, SUI is present only with the prolapse reduced (occult SUI) or may develop after surgical treatment for prolapse (de novo SUI). OBJECTIVES: To determine the impact on postoperative bladder function of surgery for symptomatic pelvic organ prolapse with or without concomitant or delayed two-stage continence procedures to treat or prevent stress urinary incontinence...
August 19, 2018: Cochrane Database of Systematic Reviews
Chen Wu, Xiaodong Li, Dachuan Zhang, Bin Xu, Wenwei Hu, Xiao Zheng, Danxia Zhu, Qi Zhou, Jingting Jiang, Changping Wu
BACKGROUND/AIMS: IL-1β is an important mediator of "inflammation-cancer" transformation through IL-1β/NF-κB/COX-2/HIF-1α signaling pathway, whereas certain portion of patients with lung adenocarcinoma (LUAD) still suffer from rapid tumor progression in clinical practice, indicating the occurrence of potential bypass. METHODS: Real-time polymerase chain reaction was applied to examine the expressions of mir-144-3p, WT1, NF-κB, COX2 and HIF-1α at the mRNA level in 127 LUAD samples and corresponding adjacent tissues...
August 17, 2018: Cellular Physiology and Biochemistry
Amélie Bernier-Jean, William Beaubien-Souligny, Thierry Ducruet, Anatolie Duca, Martin Albert, Valéry Lavergne, Josée Bouchard
PURPOSE: Recent studies suggest that acute kidney injury (AKI) can affect distant organ function and increase non-renal complications. We determined whether AKI is associated with an increased risk of incident infections. MATERIAL AND METHODS: We conducted a one-year single-center retrospective cohort study, excluding patients readmitted to the ICU or for <24 h, on chronic dialysis, and kidney transplant recipients. The primary outcome was the development of incident infections analyzed by multivariate time-dependent Cox models...
August 8, 2018: Journal of Critical Care
Claudia Mosillo, Roberto Iacovelli, Chiara Ciccarese, Emanuela Fantinel, Davide Bimbatti, Matteo Brunelli, Iolanda Bisogno, Stefania Kinspergher, Consuelo Buttigliero, Marcello Tucci, Orazio Caffo, Giampaolo Tortora
De novo metastatic castration sensitive prostate cancer (mCSPC) accounts for about 4% of all prostate tumors in Western Countries. This condition has a heterogeneous biological e clinical behavior, ranging from indolent to aggressive and rapidly fatal forms. Recently, the therapeutic landscape for mCSPC has been broadly enriched; indeed robust evidence supports the addiction of chemotherapy (docetaxel) or abiraterone acetate to androgen deprivation therapy (ADT), the latter considered for long the unique standard of care...
August 11, 2018: Cancer Treatment Reviews
Balabhadrapatruni V S K Chakravarthi, Maria Del Carmen Rodriguez Pena, Sumit Agarwal, Darshan S Chandrashekar, Sai Akshaya Hodigere Balasubramanya, Fayez J Jabboure, Andres Matoso, Trinity J Bivalacqua, Katayoon Rezaei, Alcides Chaux, William E Grizzle, Guru Sonpavde, Jennifer Gordetsky, George J Netto, Sooryanarayana Varambally
Genomic and transcriptome sequencing of bladder cancer (BLCA) has identified multiple molecular alterations during cancer progression. Many of these identified genetic and epigenetic changes play a role in the progression of this disease. Studies have identified molecular subtypes in muscle-invasive bladder cancer (MIBC) with different sensitivities to frontline therapy suggesting the heterogeneity in these tumors and the importance of molecular characterization of MIBC to provide effective treatment. Specifically, it has become increasingly evident, as demonstrated by The Cancer Genome Atlas project, that metabolic enzymes are commonly dysregulated in BLCA...
August 14, 2018: Neoplasia: An International Journal for Oncology Research
D Ferrazzoli, P Ortelli, G Riboldazzi, R Maestri, G Frazzitta
The original version of this article unfortunately contained a mistake. The funding information was incorrect. The corrected funding information is given below.
August 17, 2018: Journal of Neurology
Sarmila Majumder, Kalpana Ghoshal, Jharna Datta, Shoumei Bai, Xiaocheng Dong, Ning Quan, Christoph Plass, Samson T Jacob
No abstract text is available yet for this article.
August 17, 2018: Journal of Biological Chemistry
Gabriela Samagaio, Aída Estévez, Joaquim de Moura, Jorge Novo, María Isabel Fernández, Marcos Ortega
BACKGROUND AND OBJECTIVE: The detection and characterization of the intraretinal fluid accumulation constitutes a crucial ophthalmological issue as it provides useful information for the identification and diagnosis of the different types of Macular Edema (ME). These types are clinically defined, according to the clinical guidelines, as: Serous Retinal Detachment (SRD), Diffuse Retinal Thickening (DRT) and Cystoid Macular Edema (CME). Their accurate identification and characterization facilitate the diagnostic process, determining the disease severity and, therefore, allowing the clinicians to achieve more precise analysis and suitable treatments...
September 2018: Computer Methods and Programs in Biomedicine
Ji Woong Roh, Young-Guk Ko, Chul-Min Ahn, Sung-Jin Hong, Dong-Ho Shin, Jung-Sun Kim, Byeong-Keuk Kim, Donghoon Choi, Myeong-Ki Hong, Yangsoo Jang
BACKGROUND: Currently, there exists limited data on patient outcome following the use of drug-coated balloons to treat complex femoropopliteal arterial occlusive lesions. The aim of the present study was to investigate the outcomes of patient treated with drug-coated balloons (DCB) and to identify predictors of restenosis. METHODS: We retrospectively investigated medical records from 120 patients (137 limbs) treated with DCBs for femoropopliteal lesions at a single center between 2013 and 2016...
August 14, 2018: Annals of Vascular Surgery
Kristina Preuer, Philipp Renz, Thomas Unterthiner, Sepp Hochreiter, G Uuml Nter Klambauer
The new wave of successful generative models in machine learning has increased the interest in deep learning driven de novo drug design. However, method comparison is difficult because of various flaws of the currently employed evaluation metrics. We propose an evaluation metric for generative models called Fréchet ChemblNet distance (FCD). The FCD's advantage over previous metrics is that it can detect whether generated molecules are diverse and have similar chemical and biological properties as real molecules...
August 17, 2018: Journal of Chemical Information and Modeling
Miho Tatsuki, Kazuo Soeno, Yukihisa Shimada, Yutaka Sawamura, Yuko Suesada, Hideaki Yaegaki, Akiko Sato, Yusuke Kakei, Ayako Nakamura, Songling Bai, Takaya Moriguchi, Naoko Nakajima
Melting-flesh peaches produce large amounts of ethylene, resulting in rapid fruit softening at the late-ripening stage. In contrast, stony hard peaches do not soften and produce little ethylene. The indole-3-acetic acid (IAA) level in stony hard peaches is low at the late-ripening stage, resulting in low ethylene production and inhibition of fruit softening. To elucidate the mechanism of low IAA concentration in stony hard peaches, endogenous levels of IAA and IAA intermediates or metabolites were analysed by ultra-performance liquid chromatography-tandem mass spectrometry...
August 17, 2018: Plant Journal: for Cell and Molecular Biology
Sami H Jezzini, Amelia Merced, Jonathan M Blagburn
The synapse between auditory Johnston's Organ neurons (JONs) and the giant fiber (GF) of Drosophila is structurally mixed, being composed of cholinergic chemical synapses and Neurobiotin- (NB) permeable gap junctions, which consist of the innexin Shaking-B (ShakB). Previous observations showed that misexpression of one ShakB isoform, ShakB(N+16), in a subset of JONs that do not normally form gap junctions results in their de novo dye coupling to the GF. Misexpression of the transcription factor Engrailed (En) in these neurons also has this effect, and in addition causes the formation of new chemical synapses...
2018: PloS One
Gert Peters, Jo Maertens, Jeroen Lammertyn, Marjan De Mey
Metabolic engineering increasingly depends upon RNA technology to customly rewire the metabolism to maximize production. To this end, pure riboregulators allow dynamic gene repression without the need of a potentially burdensome coexpressed protein like typical Hfq binding small RNAs and clustered regularly interspaced short palindromic repeats technology. Despite this clear advantage, no clear general design principles are available to de novo develop repressing riboregulators, limiting the availability and the reliable development of these type of riboregulators...
August 17, 2018: PLoS Computational Biology
Ilya R Bederman, Gavriella Pora, Maureen O'Reilly, James Poleman, Kimberly Spoonhower, Michelle Puchowicz, Aura Perez, Bernadette O Erokwu, Alex Rodriguez-Palacios, Chris A Flask, Mitchell L Drumm
Negative energy balance is a prevalent feature of cystic fibrosis (CF). Pancreatic insufficiency, elevated energy expenditure, lung disease, and malnutrition, all characteristic of CF, contribute to the negative energy balance causing low bodily growth phenotype. As low body weight and BMI strongly correlate with poor lung health and survival of CF patients, improving energy balance is an important clinical goal (e.g. high-fat diet). CF mouse models also exhibit negative energy balance (growth retardation and high energy expenditure), independent from exocrine pancreatic insufficiency, lung disease, and malnutrition...
August 17, 2018: American Journal of Physiology. Gastrointestinal and Liver Physiology
Jackie Lang, Adrienne Barber, Sue Biggins
Chromosome segregation depends on the kinetochore, the machine that establishes force-bearing attachments between DNA and spindle microtubules. Kinetochores are formed every cell cycle via a highly regulated process that requires coordinated assembly of multiple subcomplexes on specialized chromatin. To elucidate the underlying mechanisms, we developed an assay to assemble kinetochores de novo using centromeric DNA and budding yeast extracts. Assembly is enhanced by mitotic phosphorylation of the Dsn1 kinetochore protein and generates kinetochores capable of binding microtubules...
August 17, 2018: ELife
N Tahiliani, P Kataria, A Patel, P Kendre
Multiple myeloma (MM) is a monoclonal gammopathy, also known as the malignant proliferation of plasma cells, presenting with typical complications such as hypercalcemia, osteolytic bone lesions, anemia, renal insufficiency, and frequent infections. Central nervous system (CNS) involvement in MM in the form of parenchymal involvement is very uncommon and has been reported only in 1% of patients. CNS involvement as an initial presentation is very rare and has poor prognosis. Also specific treatment guidelines do not exist for the treatment of such patients...
August 17, 2018: Journal of Postgraduate Medicine
Anna M Tiefes, Till Hartlieb, Moritz Tacke, Celina von Stülpnagel-Steinbeis, Line H G Larsen, Quin Hao, Hans Atli Dahl, Bernd A Neubauer, Lucia Gerstl, Manfred Kudernatsch, Gerhard J Kluger, Ingo Borggraefe
Patients with temporal lobe epilepsy (TLE) due to mesial temporal sclerosis (MTS) are eligible candidates for resective epilepsy surgery. We report on 2 male patients aged 4 years with suspected TLE due to MTS who were referred for presurgical evaluation. Both patients came to medical attention within the first year of life suffering from febrile status epileptici and subsequent unprovoked seizures. The following years, moderate developmental delay was present. High-resolution magnetic resonance imaging confirmed hippocampal sclerosis...
August 17, 2018: Clinical EEG and Neuroscience: Official Journal of the EEG and Clinical Neuroscience Society (ENCS)
Takumi Nakamura, Kotori Jimbo, Kazuo Nakajima, Takashi Tsuboi, Tadafumi Kato
AIM: We previously performed the first trio-based exome study for bipolar disorder and identified 71 de novo mutations. Among these mutations, the only mutation located at the splice donor site was in UNC13B. We focused on and analyzed the functions of the mutation. METHODS: In order to analyze the functional alterations, due to the mutation, we performed a minigene splicing assay. KEY RESULTS: We found that the mutation caused the loss of a wild-type splicing variant, which was consistent with the computational splice prediction, and that an exon-skipping variant increased significantly...
August 17, 2018: Neuropsychopharmacology reports
Rita Assi, Hatice D Gur, Sanam Loghavi, Sergej N Konoplev, Marina Konopleva, Naval Daver, Mehrnoosh Tashakori, Tapan Kadia, Mark Routbort, Alireza Salem, Rashmi Kanagal-Shamanna, Andres Quesada, Elias J Jabbour, Steven M Kornblau, L Jeffrey Medeiros, Hagop Kantarjian, Joseph D Khoury
Although ~50% of acute myeloid leukemia (AML) patients have a normal diploid karyotype by conventional cytogenetics at diagnosis, this patient subset has a variable disease course and outcome. Aberrant overexpression of the p53 protein is usually associated with TP53 alterations and a complex karyotype, but the prevalence and impact of p53 overexpression in AML with diploid cytogenetics is unknown. We examined 100 newly diagnosed AML patients to evaluate the impact of p53 expression status quantified in bone marrow core biopsy samples using immunohistochemistry and computer-assisted image analysis...
August 16, 2018: American Journal of Hematology
Cynthia S Fok, Xiang Gao, Huaiying Lin, Krystal J Thomas-White, Elizabeth R Mueller, Alan J Wolfe, Qunfeng Dong, Linda Brubaker
INTRODUCTION AND HYPOTHESIS: Persistent and de novo symptoms decrease satisfaction after urogynecologic surgery. We investigated whether the preoperative bladder microbiome is associated with urinary symptoms prior to and after urogynecologic surgery. METHODS: One hundred twenty-six participants contributed responses to the validated OABq symptom questionnaire. Catheterized (bladder) urine samples and vaginal and perineal swabs were collected immediately preoperatively...
August 16, 2018: International Urogynecology Journal
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