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Manual therapy and asthma

Roberto W Dal Negro, Massimiliano Povero
BACKGROUND: Inhalation devices represent per sé critical factors because they can affect the therapeutic outcomes independently of the drug used. The role of patients' usability and preference (PUP) for Dry Powder Inhalers (DPIs) is high indeed because they can influence the extent of the adherence to treatment and the therapeutic outcomes. Aim of the study was to assess and compare the PUP of three different DPIs in out-patients with persistent airflow limitation due to asthma or COPD...
2016: Multidisciplinary Respiratory Medicine
Jian Luo, Dan Liu, Chun-Tao Liu
Effects of antiinterleukin 13 therapies in patients with asthma remain inconsistent. Therefore, we aimed to further clarify the efficacy and safety of antiinterleukin 13 therapies in adult asthmatics by a systematic review and meta-analysis.Randomized controlled trials which reported pulmonary functions, fraction of exhaled nitric oxide (FeNO), Asthma Control Questionnaire (ACQ), rescue use of short-acting-β-agonist (SABA), and rate of asthmatic exacerbation and adverse events were identified in Pubmed, Embase, Medline, Cochrane Central Register of Controlled Trials (CENTRAL), American College of Physician (ACP) Journal Club, and ISI Web of Science, reference lists and by manual searches...
February 2016: Medicine (Baltimore)
Wen-Qian Wang, Yu-Dong Xu, Long-Ping Cui, Lei-Miao Yin, Yu Wang, Yan-Yan Liu, Yong-Qing Yang
BACKGROUND: There is some evidence to support the use of acupuncture as an alternative therapy for asthma. However, the mechanisms underlying its effects are not fully understood. We have reported previously that acupuncture has beneficial effects on asthma without changing the concentration of serum cortisol, although endogenous glucocorticoid (GC) plays an important role in regulating immune responses. OBJECTIVE: In this study, bilateral adrenalectomy (removal of both adrenal glands) was performed in rats before asthma model induction to investigate whether acupuncture influences asthma in a GC-dependent manner...
January 22, 2016: Acupuncture in Medicine: Journal of the British Medical Acupuncture Society
R Andrew McIvor
OBJECTIVE: Asthma is a chronic inflammatory disorder of the airways with increasing worldwide prevalence. Despite treatment according to guidelines, a considerable proportion of patients with asthma remain symptomatic. Different potential therapeutic options for the treatment of these patients are currently in development and undergoing clinical trials, and it is important to regularly review their status. DATA SOURCES: A search of was performed and supported by a PubMed literature search and restricted to the previous 10 years to ensure currency of data...
October 2015: Annals of Allergy, Asthma & Immunology
Eric R Coon, Christopher G Maloney, Mark W Shen
BACKGROUND AND OBJECTIVE: Imperfect diagnostic tools make it difficult to know the extent to which a bacterial process is contributing to respiratory illness, complicating the decision to prescribe antibiotics. We sought to quantify diagnostic and antibiotic prescribing disagreements between emergency department (ED) and pediatric hospitalist physicians for children admitted with respiratory illness. METHODS: Manual chart review was used to identify testing, diagnostic, and antibiotic prescribing decisions for consecutive children admitted for respiratory illness in a winter (starting February 20, 2012) and a summer (starting August 20, 2012) season to a tertiary, freestanding children's hospital...
March 2015: Hospital Pediatrics
Jimmy K Chong, Bhupendrasinh F Chauhan
UNLABELLED: For the current issue of the Journal, we asked Drs Jimmy Chong and Bhupendrasinh Chauhan to comment on and put into context the Cochrane Review on the efficacy and safety of adding antileukotriene agents (LTRAs) to low-dose inhaled corticosteroids (ICS) in children with persistent asthma (1). BACKGROUND: In the treatment of children with mild persistent asthma, low-dose ICS are recommended as the preferred monotherapy (referred to as step 2 of therapy)...
November 2014: Paediatrics & Child Health
Mark Laslett, Michael Steele, Wayne Hing, Peter McNair, Angela Cadogan
OBJECTIVE: Identify predictor variables and models for clinical outcomes for primary care shoulder pain patients to 12 months follow-up. DESIGN: A non-randomized audit with measures of pain and disability at 3 weeks, 3, 6 and 12 months. PATIENTS: Of 208 patients, 161 agreed to participate with 96.9, 98.1, 87.0 and 83.9% follow-up at 3 weeks, 3, 6 and 12 months respectively. Treatment consisted of exercise and manual therapy-based physiotherapy and corticosteroid injection under specified selection criteria...
January 2015: Journal of Rehabilitation Medicine
Giancarlo Tirelli, Annalisa Gatto, Giacomo Spinato, Margherita Tofanelli
BACKGROUND: Nasal polyposis (NP) is defined as a specific form of chronic rhinosinusitis (CRS), characterized by bilateral and multifocal polyps. Functional endoscopic sinus surgery represents the gold standard therapy when medical treatment fails. The availability of different tools raises the question of which one provides significant advances in technique and surgical outcome. This study considered the outcome of the surgical treatment of NP in relation to several comorbidities and the surgical device used: the microdebrider versus the Blakesley traditional forceps...
November 2013: American Journal of Rhinology & Allergy
Vanessa Cristina Waetge Pires de Godoy, Nathalia Mendonça Zanetti, Cíntia Johnston
OBJECTIVE: To perform an assessment of the available literature on manual hyperinflation as a respiratory physical therapy technique used in pediatric patients, with the main outcome of achieving airway clearance. METHODS: We reviewed articles included in the Lilacs (Latin American and Caribbean Literature on Health Sciences/Literatura Latino Americana e do Caribe em Ciências da Saúde), Cochrane Library, Medline (via Virtual Health Library and PubMed), SciELO (Scientific Electronic Library), and PEDro (Physiotherapy Evidence Database) databases from 2002 to 2013 using the following search terms: "physiotherapy (techniques)", "respiratory therapy", "intensive care", and "airway clearance"...
July 2013: Revista Brasileira de Terapia Intensiva
I Federico Fernandez Nievas, Kanwaljeet J S Anand
OBJECTIVES: An increasing prevalence of pediatric asthma has led to increasing burdens of critical illness in children with severe acute asthma exacerbations, often leading to respiratory distress, progressive hypoxia, and respiratory failure. We review the definitions, epidemiology, pathophysiology, and clinical manifestations of severe acute asthma, with a view to developing an evidence-based, stepwise approach for escalating therapy in these patients. METHODS: Subject headings related to asthma, status asthmaticus, critical asthma, and drug therapy were used in a MEDLINE search (1980-2012), supplemented by a manual search of personal files, references cited in the reviewed articles, and treatment algorithms developed within Le Bonheur Children's Hospital...
April 2013: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
Adesua Y Okupa, Christine A Sorkness, David T Mauger, Daniel J Jackson, Robert F Lemanske
BACKGROUND: Presently, there is insufficient information to compare the value of daily diaries vs retrospective questionnaires for assessing symptoms in relationship to asthma control in clinical trials. Daily symptom diaries are often burdensome to gather, incomplete, susceptible to fabrication, and of questionable reliability. There is also concern that retrospective symptom questionnaires may be subject to poor recall and may be insensitive. METHODS: To compare these two methods of assessing symptoms reporting, we analyzed data collected during the Best Add-on Therapy Giving Effective Responses (BADGER) trial...
April 2013: Chest
Yong-Qing Yang, Han-Ping Chen, Yu Wang, Lei-Miao Yin, Yu-Dong Xu, Jun Ran
This study examines the clinical and immunomodulatory effects of acupuncture in the treatment of patients with allergic asthma. The acupuncture points GV14, BL12, and BL13 were selected based on the theory of traditional Chinese medicine in treating asthma. Manual acupuncture was performed once every other day (three times per week) for 5 weeks. The needles were twisted approximately 360° evenly at the rate of 60 times/min for 20 s, manipulated every 10 min and withdrawn after 30 min. Concentrations of sIgA and total IgA in secretions were determined by the combination of sucrose density gradient ultracentrifugation and RIA...
June 2013: Clinical Reviews in Allergy & Immunology
Stanley J Szefler, Vernon M Chinchilli, Elliot Israel, Loren Clark Denlinger, Robert F Lemanske, William Calhoun, Stephen P Peters
The National Heart, Lung and Blood Institute (NHLBI) Asthma Clinical Research Network (ACRN) recently completed its work after 20 years of collaboration as a multicentre clinical trial network. When formed, its stated mission was to perform multiple controlled clinical trials for treating patients with asthma by dispassionately examining new and existing therapies, and to rapidly communicate its findings to the medical community. The ACRN conducted 15 major clinical trials. In addition, clinical data, manual of operations, protocols and template informed consents from all ACRN trials are available via NHLBI BioLINCC (https://biolincc...
May 2012: Thorax
John Burgess, Buddhini Ekanayake, Adrian Lowe, David Dunt, Francis Thien, Shyamali C Dharmage
In asthma management, complementary and alternative medicine is enjoying a growing popularity worldwide. This review synthesizes the literature on complementary and alternative medicine techniques that utilize breathing retraining as their primary component and compares evidence from controlled trials with before-and-after trials. Medline, PubMed, Cumulative Index to Nursing and Allied Health Literature and the Cochrane Library electronic databases were searched. Reference lists of all publications were manually checked to identify studies not found through electronic searching...
December 2011: Expert Review of Respiratory Medicine
M E Borke, M U Nwagu, D Obaseki, N O Bazuaye
BACKGROUND: Churg Strauss syndrome is a medical condition of unknown aetiology characterized by asthma, eosinophilia and finally vasculitis involving small vessels in the limbs and nasal sinuses and the lungs. The purpose of this review is to highlight the natural history of this condition, the pathogenesis, clinical features and treatment modalities available and the prognosis. METHODS: Literature on the subject was reviewed using manual library search, articles in journals, internet search and conference abstracts...
April 2010: Nigerian Journal of Medicine: Journal of the National Association of Resident Doctors of Nigeria
Pierachille Santus, Francesca Giovannelli, Fabiano Di Marco, Stefano Centanni
IMPORTANCE OF THE FIELD: Asthma is a heterogeneous disease with various components that may contribute to symptoms. Obtaining global control of is one of the fundamental parts of the management of this disease. AREAS COVERED IN THIS REVIEW: The Cochrane trial database, Medline and Embase, were searched systematically, and approximately 20 respiratory journals and conference abstracts were searched manually. The search was limited to publications in English language of last 20 years and which included the keywords 'budesonide', 'formoterol', 'asthma' and 'control'...
February 2010: Expert Opinion on Pharmacotherapy
Flory L Nkoy, Bernhard A Fassl, Tamara D Simon, Bryan L Stone, Rajendu Srivastava, Per H Gesteland, Gena M Fletcher, Christopher G Maloney
OBJECTIVES: The goals were (1) to identify evidence-based clinical process measures that are appropriate, feasible, and reliable for assessing the quality of inpatient asthma care for children and (2) to evaluate provider compliance with these measures. METHODS: Key asthma quality measures were identified by using a modified Rand appropriateness method, combining a literature review of asthma care evidence with a consensus panel. The feasibility and reliability of obtaining these measures were determined through manual chart review...
November 2008: Pediatrics
T H Voshaar
The prescription of an inhalative therapy by the physician is not only based on pharmacological aspects, but also on the physical characteristics of the inhalation device, the special and dose-relevant galenics as well as on the patient's individual situation, e. g. disease severity, the intellectual and manual skills. The correct use of the various devices has to be trained and controlled. This approach is also fixed in the Disease Management Programmes (DMP) for asthma and COPD. The substitution of inhalation devices without consideration of the above-mentioned criteria and without retraining is contradictory to all recommendations of national and international respiratory societies and may put the patients at risk...
November 2008: Pneumologie
Mónica Abella, José Manuel Zubeldia, Laura Conejero, Norberto Malpica, Juan José Vaquero, Manuel Desco
The evaluation of new therapies to treat allergic asthma makes frequent use of histological studies. Some of them are based on microscope observation of stained paraffin lung sections to quantify cellular infiltrate, an effect directly related to allergic processes. Currently, there is no software tool available for doing this quantification automatically. This paper presents a methodology and a software tool for the quantification of cellular infiltrate in lung tissue images in an allergic asthma mouse model...
March 2009: Cytometry. Part A: the Journal of the International Society for Analytical Cytology
E Sherwood Brown, Dixie J Woolston, Alan B Frol
BACKGROUND: Hippocampal volume reduction and declarative memory deficits are reported in humans and animals exposed to exogenous corticosteroids. The amygdala is another brain structure involved in the stress response that has important interactions with the hypothalamic-pituitary-adrenal axis. To our knowledge, no studies in animals or humans have examined the impact of exogenous corticosteroid administration on the amygdala. We assessed amygdala volume in patients receiving chronic prescription corticosteroid therapy and control subjects with similar medical histories not receiving corticosteroids...
April 1, 2008: Biological Psychiatry
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