keyword
https://read.qxmd.com/read/38546336/corrigendum-lack-of-methoxy-mycolates-characterizes-the-geographically-restricted-lineage-7-of-mycobacterium-tuberculosis-complex
#1
JOURNAL ARTICLE
Elena Hailu, Daire Cantillon, Carlos Madrazo, Graham Rose, Paul R Wheeler, Paul Golby, Bethlehem Adnew, Sebastien Gagneux, Abraham Aseffa, Stephen V Gordon, Iñaki Comas, Douglas B Young, Simon J Waddell, Gerald Larrouy-Maumus, Stefan Berg
No abstract text is available yet for this article.
March 2024: Microbial Genomics
https://read.qxmd.com/read/38532307/120-years-of-ecological-monitoring-data-shows-that-the-risk-of-overhunting-is-increased-by-environmental-degradation-for-an-isolated-marine-mammal-population-the-baltic-grey-seal
#2
REVIEW
Daire Carroll, Markus P Ahola, Anja M Carlsson, Martin Sköld, Karin C Harding
The Baltic Sea is home to a genetically isolated and morphologically distinct grey seal population. This population has been the subject of 120-years of careful documentation, from detailed records of bounty statistics to annual monitoring of health and abundance. It has also been exposed to a range of well-documented stressors, including hunting, pollution and climate change. To investigate the vulnerability of marine mammal populations to multiple stressors, data series relating to the Baltic grey seal population size, hunt and health were compiled, vital demographic rates were estimated, and a detailed population model was constructed...
March 26, 2024: Journal of Animal Ecology
https://read.qxmd.com/read/38531489/lower-rates-of-re-operation-following-partial-or-complete-revision-arthroplasty-compared-to-debridement-antibiotics-and-implant-retention-for-early-postoperative-and-acute-hematogenous-periprosthetic-hip-infection
#3
JOURNAL ARTICLE
Nicholas Tubin, Jonathan Bourget-Murray, Antoine Bureau, Jared Morris, Marisa Ann Azad, Hesham Abdelbary, George Grammatopoulos, Simon Garceau
INTRODUCTION: This study aimed to: 1) compare treatment outcomes between debridement, antibiotics, and implant retention (DAIR) and partial or complete revision arthroplasty (RA) for early postoperative and acute hematogenous total hip arthroplasty (THA) periprosthetic joint injection (PJI) and 2) identify factors associated with treatment outcome. METHODS: The study consisted of a retrospective cohort of patients who underwent surgery for PJI between 2004 and 2021...
March 24, 2024: Journal of Arthroplasty
https://read.qxmd.com/read/38520549/are-silver-coated-megaprostheses-superior-to-uncoated-megaprostheses-in-managing-chronic-end-stage-periprosthetic-hip-and-knee-infection
#4
JOURNAL ARTICLE
Matías Vicente, Josep Nomdedeu, Kushal Lakhani, Pablo S Corona
INTRODUCTION: Outcomes for silver coated megaprostheses (SC-MP) used in cases of end-stage periprosthetic joint infection (PJI) have not been clearly defined. Although attractive, concerns over implant longevity and the risk of infection relapse exist among the scientific community. Therefore, we sought to investigate the effect of silver coating in lower-extremity MPs used in such difficult-to-treat scenarios. The study's primary hypothesis was that the periprosthetic infection control rate would be higher in patients with silver-coated implants...
March 23, 2024: Archives of Orthopaedic and Trauma Surgery
https://read.qxmd.com/read/38517016/implant-retention-in-a-rabbit-model-of-fracture-related-infection
#5
JOURNAL ARTICLE
Jan Puetzler, Alejandro Vallejo Diaz, Georg Gosheger, Martin Schulze, Daniel Arens, Stephan Zeiter, Claudia Siverino, Robert G Richards, Thomas F Moriarty
AIMS: Fracture-related infection (FRI) is commonly classified based on the time of onset of symptoms. Early infections (< two weeks) are treated with debridement, antibiotics, and implant retention (DAIR). For late infections (> ten weeks), guidelines recommend implant removal due to tolerant biofilms. For delayed infections (two to ten weeks), recommendations are unclear. In this study we compared infection clearance and bone healing in early and delayed FRI treated with DAIR in a rabbit model...
March 22, 2024: Bone & Joint Research
https://read.qxmd.com/read/38512501/posterior-vitreous-detachment-rates-post-uncomplicated-phacoemulsification-surgery-a-systematic-review
#6
JOURNAL ARTICLE
Daire J Hurley, Patrick Murtagh, Marc Guerin
PURPOSE: It is commonly accepted that phacoemulsification surgery is a risk factor for the development of posterior vitreous detachment (PVD) and may accelerate the process. This is an important consideration particularly in cases involving young patients who pre-operatively have no PVD, given the increased risk of retinal tears and detachments. METHODS: A comprehensive literature search was conducted to identify studies reporting incidence of PVD post-uncomplicated phacoemulsification surgery...
March 21, 2024: International Ophthalmology
https://read.qxmd.com/read/38506739/redo-tavi-with-the-acurate-neo2-and-prime-xl-for-balloon-expandable-transcatheter-heart-valve-failure
#7
JOURNAL ARTICLE
David Meier, Daire Grant, Chris Frawley, Mariama Akodad, Uri Landes, Arif A Kokhar, Dariusz Dudek, Isaac George, Michael J Rinaldi, Won-Keun Kim, Steven J Yakubov, Paul Sorajja, Giuseppe Tarantini, David A Wood, John G Webb, Stephanie L Sellers, Janarthanan Sathananthan
BACKGROUND: There are limited data regarding treatment for failed balloon-expandable transcatheter heart valves (THVs) in redo-transcatheter aortic valve implantation (TAVI). AIMS: We aimed to assess THV performance, neoskirt height and expansion when performing redo-TAVI with the ACURATE platform inside a SAPIEN 3 (S3) compared to redo-TAVI with an S3 in an S3. METHODS: Redo-TAVI was performed on the bench using each available size of the S3, the ACURATE neo2 (ACn2) and the next-generation ACURATE Prime XL (AC XL) implanted at 2 different depths within 20 mm/23 mm/26 mm/29 mm S3s serving as the "failed" index THV...
March 18, 2024: EuroIntervention
https://read.qxmd.com/read/38503683/established-and-emerging-treatments-for-eating-disorders
#8
REVIEW
Callum Bryson, Daire Douglas, Ulrike Schmidt
Eating disorders (EDs) are common mental health conditions that carry exceedingly high morbidity and mortality rates. Evidence-based treatment options include a range of psychotherapies and some, mainly adjunctive, pharmacological interventions. However, around 20-30% of people fail to respond to the best available treatments and develop a persistent treatment-refractory illness. Novel treatments for these disorders are emerging, but their efficacy and clinical relevance need further investigation. In this review article, we first outline the evidence-base for the established treatments of the three 'classical' EDs [anorexia nervosa (AN), bulimia nervosa (BN), and binge eating disorder (BED)]...
March 18, 2024: Trends in Molecular Medicine
https://read.qxmd.com/read/38499712/dual-mobility-tripod-cup-for-revision-hip-arthroplasty-long-term-five-to-fourteen-years-evaluation-of-a-new-generation-cementless-implant
#9
JOURNAL ARTICLE
Aurélien Klein, Maxence Bordes, Anthony Viste, Michel Fessy
PURPOSE: The aims of this study were to evaluate the survivorships of a new generation cementless DMC with tripod additional fixation in revision total hip arthroplasty and complications at a minimum five year follow-up. METHODS: One hundred and fifteen revisions (THA) treated with tripod DMC performed between 2009 and 2015 were included in this retrospective study. Acetabular defects were classified as Paprosky 1 (n = 38, 33%), 2 (n = 75, 65%) or 3 (n = 2, 2%)...
March 19, 2024: International Orthopaedics
https://read.qxmd.com/read/38497148/low-dose-non-steroidal-anti-inflammatory-drugs-a-promising-approach-for-the-treatment-of-symptomatic-bone-marrow-failure-in-ghosal-hematodiaphyseal-dysplasia
#10
JOURNAL ARTICLE
Jonathan Bordat, Felipe Suarez, Valérie Cormier-Daire, Regis Peffault De Latour, Jean Soulier, Veronique Meignin, Mathilde Doyard, Lise Larcher, Stephane Vanderbecken, Flore Sicre De Fontbrune
Not available.
March 14, 2024: Haematologica
https://read.qxmd.com/read/38477767/identification-of-kinesin-family-member-kif22-homozygous-variants-in-spondyloepimetaphyseal-dysplasia-with-joint-laxity-lepdodactylic-type-and-demonstration-of-proteoglycan-biosynthesis-impairment
#11
JOURNAL ARTICLE
Johanne Dubail, Sophie Rondeau, Caroline Michot, Geneviève Baujat, Yline Capri, Julien Thévenon, Maelle Charpie, Zagorka Pejin, Gilles Phan, Céline Huber, Valérie Cormier-Daire
Heterozygous variants in KIF22, encoding a kinesin-like protein, are responsible for spondyloepimetaphyseal dysplasia with joint laxity, leptodactilic type (lepto-SEMDJL), characterized by short stature, flat face, generalized joint laxity with multiple dislocations, and progressive scoliosis and limb deformity. By targeted gene sequencing analysis, we identified a homozygous KIF22 variant (NM_007317.3: c.146G>A, p.Arg49Gln) in 3 patients from 3 unrelated families. The clinical features appeared similar to those of patients carrying heterozygous KIF22 variant (c...
January 4, 2024: Journal of Bone and Mineral Research
https://read.qxmd.com/read/38452787/prevalence-of-multimorbidity-and-polypharmacy-among-adults-and-older-adults-a-systematic-review
#12
REVIEW
Kathryn Nicholson, Winnie Liu, Daire Fitzpatrick, Kate Anne Hardacre, Sarah Roberts, Jennifer Salerno, Saverio Stranges, Martin Fortin, Dee Mangin
Multimorbidity (multiple conditions) and polypharmacy (multiple medications) are increasingly common, yet there is a need to better understand the prevalence of co-occurrence. In this systematic review, we examined the prevalence of multimorbidity and polypharmacy among adults (≥18 years) and older adults (≥65 years) in clinical and community settings. Six electronic databases were searched, and 87 studies were retained after two levels of screening. Most studies focused on adults 65 years and older and were done in population-based community settings...
March 4, 2024: The Lancet. Healthy longevity
https://read.qxmd.com/read/38437228/cold-temperature-induces-a-trpm8-independent-calcium-release-from-the-endoplasmic-reticulum-in-human-platelets
#13
JOURNAL ARTICLE
Anastasiia Stratiievska, Olga Filippova, Tahsin Özpolat, Daire Byrne, S Lawrence Bailey, Aastha Chauhan, Molly Y Mollica, Jeff Harris, Kali Esancy, Junmei Chen, Ajay K Dhaka, Nathan J Sniadecki, José A López, Moritz Stolla
The detection of temperature by the human sensory system is life-preserving and highly evolutionarily conserved. Platelets are sensitive to temperature changes and are activated by a decrease in temperature, akin to sensory neurons. However, the molecular mechanism of this temperature-sensing ability is unknown. Yet, platelet activation by temperature could contribute to numerous clinical sequelae, most importantly to reduced quality of ex vivo-stored platelets for transfusion. In this multidisciplinary study, we present evidence for the expression of the temperature-sensitive ion channel transient receptor potential cation channel subfamily member 8 (TRPM8) in human platelets and precursor cells...
2024: PloS One
https://read.qxmd.com/read/38436674/phage-therapy-in-prosthetic-joint-infections-caused-by-staphylococcus-aureus-a-literature-review
#14
REVIEW
Vincent A Eiselt, Stefan Bereswill, Markus M Heimesaat
Prosthetic joint infections (PJIs) are dreaded arthroplasty complications often caused by Staphylococcus aureus. Due to methicillin-resistant S. aureus (MRSA) strains or biofilm formation, successful treatment remains difficult. Currently, two-stage revision surgery constitutes the gold standard therapy of PJIs, sometimes replaced or supplemented by debridement, antibiotics, and implant retention (DAIR). Given the dire consequences of therapeutic failure, bacteriophage therapy might be another treatment option...
March 4, 2024: European Journal of Microbiology & Immunology
https://read.qxmd.com/read/38427589/platelet-dysfunction-reversal-with-cold-stored-vs-room-temperature-stored-platelet-transfusions
#15
JOURNAL ARTICLE
Valery J Kogler, Jeffrey Miles, Tahsin Ozpolat, S Lawrence Bailey, Daire Ann Byrne, Morgan Bawcom-Randall, Yi Wang, Hannah Larsen, Franklin Reed, Xiaoyun Fu, Moritz Stolla
Platelets are stored at room temperature for 5-7 days (RSP). Due to frequent and severe shortages, the FDA recently approved up to 14-day cold-stored platelets in plasma (CSP). However, the post-transfusion function of CSP is unknown and it is unclear which donors are best suited to provide either RSP or CSP. In this study, we sought to evaluate the post-transfusion platelet function and its predictors for platelets stored for the maximum approved storage times (7-day RSP, 14-day CSP) in healthy volunteers on acetylsalicylic acid (ASA)...
March 1, 2024: Blood
https://read.qxmd.com/read/38401619/the-mark-coventry-award-photothermaa-gel-combined-with-debridement-antibiotics-and-implant-retention-dair-significantly-decreases-implant-biofilm-burden-and-soft-tissue-infection-in-a-rabbit-model-of-knee-periprosthetic-joint-infection
#16
JOURNAL ARTICLE
Carlos A Higuera-Rueda, Nicolas S Piuzzi, Nathalie B Milbrandt, Yu Hsin Tsai, Alison K Klika, Anna Cristina S Samia, Anabelle Visperas
BACKGROUND: Chronic periprosthetic joint infection (PJI) is a major complication of total joint arthroplasty. The underlying pathogenesis often involves the formation of bacterial biofilm that protects the pathogen from both host immune responses and antibiotics. The gold standard treatment requires implant removal, a procedure that carries associated morbidity and mortality risks. Strategies to preserve the implant while treating PJI are desperately needed. Our group has developed an anti-biofilm treatment, PhotothermAA gel, that has shown complete eradication of two-week-old mature biofilm in vitro...
February 22, 2024: Journal of Arthroplasty
https://read.qxmd.com/read/38385987/novel-variant-in-lrp6-associated-with-unusual-and-severe-clinical-presentation-case-report
#17
JOURNAL ARTICLE
Anaïk Previdi, Christèle Dubourg, Valérie Cormier Daire, Mélanie Fradin, Corinne Collet
Low-density lipoprotein receptor-related protein 6 (LRP6) is a co-receptor of the Wnt signaling pathway, which plays an essential role in various biological activities during embryonic and postnatal development. LRP6 is exceptionally associated with rare diseases and always with autosomal dominant inheritance. Here we report a familial phenotype of high bone mass associated with skeletal anomalies and oligodontia but also persistent left superior vena cava, inguinal hernia, hepatic cysts, abnormal posterior fossa and genital malformations...
February 22, 2024: Clinical Genetics
https://read.qxmd.com/read/38365837/a-comparative-analysis-of-student-educator-and-simulated-parent-ratings-of-video-recorded-medical-student-consultations-in-pediatrics
#18
JOURNAL ARTICLE
Clare C Sullivan, Daire M O'Leary, Fiona M Boland, Claire M Condron, Claire M Mulhall, Walter J Eppich
BACKGROUND: Simulation-based education (SBE) affords learners opportunities to develop communication skills, including those related to pediatrics. Feedback is an integral part of SBE, and while much research into feedback from multiple sources exists, the findings are mixed. The aim of this comparative study was to replicate some of this work in a novel area, pediatric medical education, to better understand how multisource feedback (self, educator, and simulated parent) may inform learning and curriculum design...
February 17, 2024: Advances in Simulation
https://read.qxmd.com/read/38359149/what-is-the-most-effective-treatment-for-periprosthetic-joint-infection-after-total-joint-arthroplasty-in-patients-with-rheumatoid-arthritis-a-systematic-review
#19
JOURNAL ARTICLE
Vineet Desai, Alexander R Farid, Adriana P Liimakka, Jaime Lora-Tamayo, Marjan Wouthuyzen-Bakker, Jesse W P Kuiper, Nemandra Sandiford, Antonia F Chen
BACKGROUND: Rheumatoid arthritis (RA) is a risk factor for periprosthetic joint infection (PJI) after total joint arthroplasty (TJA). The purpose of this study was to perform a systematic review comparing the failure rates of debridement, antibiotics, and implant retention (DAIR), one-stage exchange arthroplasty/revision (OSR), and 2-stage exchange arthroplasty/revision (TSR) for RA patients with PJI and identify risk factors in the RA population associated with increased treatment failure rate...
February 1, 2024: JBJS Reviews
https://read.qxmd.com/read/38355647/environmental-and-mineralogical-studies-on-the-stream-sediments-of-baltim-el-burullus-coastal-plain-north-delta-egypt
#20
JOURNAL ARTICLE
A M Sallam, A A Faheim, Z A El-Elshafiey, M M Abdel Azeem, M G El Feky, M Y Hanfi
This work is mainly concerned with the effect of anthropogenic activities and natural radioactivity due to the presence of highly radioactive black sand spots, factory construction, and shipping, in addition to other activities like agriculture on human beings. Forty samples were collected along Baltim-El Burullus coastal plain to detect the effect of these problems and determine the suggested solutions. The black sand of the Baltim-El Burullus coastal plain exhibits a considerable amount of economically heavy minerals, their ratio relative to the bulk composition in the investigated samples ranges from 3...
February 15, 2024: Scientific Reports
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