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Polycystic ovary treatment

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https://www.readbyqxmd.com/read/28546815/role-of-statin-drugs-for-polycystic-ovary-syndrome
#1
REVIEW
Lisa Cassidy-Vu, Edwina Joe, Julienne K Kirk
Objective: To review the potential role and specific impact of statin drugs in women with PCOS. The evidence for this use of statins in PCOS is limited and still under further investigation. Materials and methods: A search was conducted using PubMed, DynaMed and PubMedHealth databases through October 16, 2016 using the terms polycystic ovary syndrome, PCOS, hydroxymethylglutaryl-CoA reductase inhibitors, hydroxymethylglutaryl-CoA, statin, atorvastatin, fluvastatin, lovastatin, pitavastatin, pravastatin, rosuvastatin and simvastatin...
December 2016: Journal of Family & Reproductive Health
https://www.readbyqxmd.com/read/28544572/inositol-treatment-of-anovulation-in-women-with-polycystic-ovary-syndrome-a-meta-analysis-of-randomised-trials
#2
Jyotsna Pundir, Dimitrios Psaroudakis, Prakash Savnur, Priya Bhide, Luca Sabatini, Helena Teede, Arri Coomarasamy, Shakila Thangaratinam
BACKGROUND: Polycystic ovary syndrome is a common cause of anovulation and infertility, and a risk factor for development of metabolic syndrome and endometrial cancer. OBJECTIVES: Systematic review and meta-analysis of randomised controlled trials that evaluated the effects of inositol as an ovulation-induction agent. SEARCH STRATEGY: We searched MEDLINE, EMBASE, Cochrane and ISI conference proceedings, Register and Meta-register for RCTs and WHO trials' search portal...
May 24, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28539732/influence-of-pcos-in-obese-vs-non-obese-women-from-mesenchymal-progenitors-stem-cells-and-other-endometrial-cells-an-in-silico-biomarker-discovery
#3
Ashvini Desai, Inamul Hasan Madar, Amjad Hussain Asangani, Hussain Al Ssadh, Iftikhar Aslam Tayubi
Polycystic ovary syndrome (PCOS) is endocrine system disease which affect women ages 18 to 44 where the women's hormones are imbalance. Recently it has been reported to occur in early age. Alteration of normal gene expression in PCOS has shown negative effects on long-term health issues. PCOS has been the responsible factor for the infertility in women of reproductive age group. Early diagnosis and treatment can improve the women's health suffering from PCOS. Earlier Studies shows correlation of PCOS upon insulin resistance with significant outcome, Current study shows the linkage between PCOS with obesity and non-obese patients...
2017: Bioinformation
https://www.readbyqxmd.com/read/28537181/pathophysiology-diagnosis-and-treatment-of-polycystic-ovary-syndrome
#4
Priscilla Cunningham
Polycystic ovary syndrome (PCOS) is an incurable disorder that is associated with ovarian dysfunction. It affects millions of women in the UK. The signs and symptoms of PCOS include ovarian cysts, acne and excess hair growth (hirsutism), and can have a negative effect on the self-esteem of women with the condition. PCOS is also a potential cause of reduced fertility. This article uses a case study approach to discuss the pathophysiology, signs and symptoms, and diagnosis of PCOS, as well as complications, treatment and psychosocial implications of the condition...
May 24, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28534418/quantification-of-visceral-adipose-tissue-in-polycystic-ovary-syndrome-dual-energy-x-ray-absorptiometry-versus-magnetic-resonance-imaging
#5
Signe Frøssing, Malin Chatarina Nylander, Elizaveta Chabanova, Caroline Kistorp, Sven O Skouby, Jens Faber
Background Polycystic ovary syndrome (PCOS) is associated with frequent overweight and abdominal obesity. Quantifying visceral adipose tissue (VAT) in PCOS patients can be a tool to assess metabolic risk and monitor effects of treatment. The latest dual-energy X-ray absorptiometry (DXA) technology can measure VAT and subcutaneous adipose tissue (SAT) in a clinical setting. Purpose To compare DXA-measurements of VAT and SAT with the gold standard MRI in women with PCOS. Material and Methods A cross-sectional study of 67 overweight women with PCOS was performed...
January 1, 2017: Acta Radiologica
https://www.readbyqxmd.com/read/28531286/is-foetal-hyperexposure-to-androgens-a-cause-of-pcos
#6
Panagiota Filippou, Roy Homburg
BACKGROUND: Polycystic ovary syndrome (PCOS) is the most common endocrinopathy affecting reproductive-aged women. The pathophysiology of this syndrome is still not completely understood but recent evidence suggests that the intra-uterine environment may be a key factor in the pathogenesis of PCOS, in particular, hyperexposure of the foetus to androgens. High concentrations of maternal serum testosterone during pregnancy have been shown to influence behaviour during childhood, the prevalence of autism disorders and anti-Mullerian hormone (AMH) concentrations in adolescence...
May 20, 2017: Human Reproduction Update
https://www.readbyqxmd.com/read/28522293/direct-action-of-adiponectin-ameliorates-increased-androgen-synthesis-and-reduces-insulin-receptor-expression-in-the-polycystic-ovary
#7
Anusha Singh, Puran Bora, Amitabh Krishna
Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disorder of reproductive age females, leading to infertility. Despite extensive research, the exact pathophysiology and treatment are lacking. The aim of the current study was to evaluate the direct role of adiponectin either alone or together with luteinizing hormone (LH) on sex hormone synthesis and changes in insulin receptor (IR) in the ovary of dehydroepiandrosterone (DHEA)-treated PCOS-mice. Immunohistochemical study showed decreased expression of adiponectin receptor (AdipoR1) in PCOS-ovary which correlated with increased synthesis of androgen and decreased expression of IR...
May 15, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28506471/genetics-of-gonadotropins-and-their-receptors-as-markers-of-ovarian-reserve-and-response-in-controlled-ovarian-stimulation
#8
REVIEW
Laura Riccetti, Francesco De Pascali, Lisa Gilioli, Daniele Santi, Giulia Brigante, Manuela Simoni, Livio Casarini
Several controlled ovarian stimulation (COS) protocols have been developed to increase the yield of mature oocytes retrieved in assisted reproductive techniques (ARTs). The ovarian reserve (OR) influences the COS response, and it represents the main parameter that helps clinicians in refining clinical treatments in the perspective of a "personalized" ART. This approach is even more needed in particular conditions such as poor OR or polycystic ovary syndrome. Follicle-stimulating hormone, luteinizing hormone, and human chorionic gonadotropin are currently used in COS at different combinations and with different efficacies, even if the best approach definition is controversial...
April 17, 2017: Best Practice & Research. Clinical Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/28505246/effects-of-long-term-exogenous-testosterone-administration-on-ovarian-morphology-determined-by-transvaginal-3d-ultrasound-in-female-to-male-transsexuals
#9
Mirte R Caanen, Nienke E Schouten, Esther A M Kuijper, Joukje van Rijswijk, Marleen H van den Berg, Eline van Dulmen-den Broeder, Annelies Overbeek, Flora E van Leeuwen, Mick van Trotsenburg, Cornelis B Lambalk
STUDY QUESTION: Does long-term exogenous testosterone administration result in polycystic ovarian morphology (PCOM), determined by (3D) transvaginal ultrasound (TVU) in female-to-male transsexuals (FtMs). SUMMARY ANSWER: Long-term exogenous testosterone administration in FtMs does not result in PCOM determined by (3D) TVU. WHAT IS KNOWN ALREADY: The role of androgens in the pathophysiology of polycystic ovary syndrome (PCOS) is still unclear...
May 13, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28501702/brown-adipose-tissue-activation-by-rutin-ameliorates-polycystic-ovary-syndrome-in-rat
#10
Tao Hu, Xiaoxue Yuan, Rongcai Ye, Huiqiao Zhou, Jun Lin, Chuanhai Zhang, Hanlin Zhang, Gang Wei, Meng Dong, Yuanyuan Huang, Wonchung Lim, Qingsong Liu, Hyuek Jong Lee, Wanzhu Jin
Polycystic ovary syndrome (PCOS) is a complex endocrinopathy that is characterized by anovulation, hyperandrogenism and polycystic ovary. However, there is a lack of effective treatment for PCOS at present because the pathologic cause of PCOS has not been elucidated. Although it has been known that brown adipose tissue transplantation ameliorates PCOS by activating endogenous BAT, BAT transplantation is not applicable in clinic. Therefore, BAT activation with natural compound could be an effective treatment strategy for PCOS patients...
April 22, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28497664/insulin-sensitizers-in-adolescents-with-polycystic-ovary-syndrome
#11
Trang N LE, Edmond P Wickham Iii, John E Nestler
Polycystic ovary syndrome (PCOS) is the most common disorder of androgen excess in women of reproductive age. The diagnosis of PCOS can be more challenging in adolescents than in adult women given significant overlap between normal puberty and the signs of PCOS, including acne, menstrual irregularity, and polycystic ovarian morphology. Optimal treatments for adult women with PCOS vary depending on patient risk factors and reproductive goals, but mainly include hormonal contraception and insulin sensitizers...
May 11, 2017: Minerva Pediatrica
https://www.readbyqxmd.com/read/28494682/operative-transvaginal-hydrolaparoscopy-improve-ovulation-rate-after-clomiphene-failure-in-polycystic-ovary-syndrome
#12
Pierluigi Giampaolino, Nicoletta De Rosa, Luigi Della Corte, Ilaria Morra, Antonio Mercorio, Carmine Nappi, Giuseppe Bifulco
Aim of our study was to assess the ovulation rate, with mid-luteal progesterone level and ultrasound follicles monitoring, in PCOS CC-resistant patients undergone transvaginal hydrolaparoscopy ovarian drilling. A prospective observational study was carried out in 123 PCOS, infertile, CC-resistant patients who undergone THL ovarian drilling. Each woman was evaluated by hormonal measurement, and ultrasound evaluation during 6 months follow-up. Progesterone serum levels were assessed on days 20-24 of the cycle after surgical treatment...
May 11, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28486649/hyperandrogenemia-reduces-endothelium-derived-hyperpolarizing-factor-mediated-relaxation-in-mesenteric-artery-of-female-rats
#13
Jay S Mishra, Amar S More, Gary D V Hankins, Sathish Kumar
Women with polycystic ovary syndrome (PCOS) often present with hyperandrogenemia along with vascular dysfunction and elevated blood pressure. In animal models of PCOS, anti-androgen treatment decreased blood pressure, indicating a key role for androgens in the development of hypertension. However, the underlying androgen-mediated mechanism that contributes to increased blood pressure is not known. This study determined whether elevated androgens affect endothelium-derived hyperpolarizing factor (EDHF)-mediated vascular relaxation responses through alteration in function of gap junctional proteins...
May 8, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/28483503/gaps-in-knowledge-among-physicians-regarding-diagnostic-criteria-and-management-of-polycystic-ovary-syndrome
#14
Anuja Dokras, Shailly Saini, Melanie Gibson-Helm, Jay Schulkin, Laura Cooney, Helena Teede
OBJECTIVE: To identify gaps in polycystic ovary syndrome (PCOS) knowledge and practice patterns among physicians in North America in response to significant dissatisfaction identified among women with PCOS regarding their diagnosis and treatment experience. DESIGN: Online survey conducted via American College of Obstetrics and Gynecology of gynecologists (ObGyn) and American Society of Reproductive Medicine of reproductive endocrinologists (REI-ObGyn) in 2015-16...
May 5, 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28479753/the-effect-of-metformin-and-cinnamon-on-serum-anti-mullerian-hormone-in-women-having-pcos-a-double-blind-randomized-controlled-trial
#15
Budi Wiweko, Cynthia A Susanto
BACKGROUND: Polycystic ovary syndrome (PCOS) is known to be associated with insulin resistance and anti-Mullerian hormone (AMH), leading to the use of insulin-sensitizing agents (ISAs) to manage PCOS. Metformin is the most widely used ISA to treat irregular menstruation; however, the gastrointestinal side effects are quite debilitating. The development of herbal medicines such as bioactive fraction DLBS3233 offers a possibly effective treatment with minimal side effects. AIM: To determine the effect of metformin and DLBS3233 on serum AMH level...
January 2017: Journal of Human Reproductive Sciences
https://www.readbyqxmd.com/read/28476694/analysis-on-endocrine-and-metabolic-features-of-different-phenotypes-of-polycystic-ovary-syndrome-patients
#16
Feng Li, Li Yao, Hong Wu, Shihong Cao
To discuss the manifestations of endocrine and metabolism for polycystic ovary syndrome patients with different phenotype. This study selected 226 cases of Rotterdam Standard diagnosed polycystic ovary syndrome patients in People's Hospital of Zhengzhou from October 2013 to February 2015. The control group was the 100 cases of non hyperandrogen menstrual women as the control group. Polycystic ovary syndrome included 4 phenotype: /or anovulatio (O) combined with hyperandrogenism (H) and polycystic ovary morphology (P), phenotype of O and P, phenotype of H and P, and phenotype of O and P...
September 2016: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28471233/effect-of-sodium-aescinate-treatment-on-pcos-rat-model-with-insulin-resistance
#17
L Chen, L M Hu, Y F Wang, H Y Yang, X Y Huang, W Zhou, H X Sun
BACKGROUND: Recent studies indicated that insulin resistance may contribute to the pathogenesis of polycystic ovary syndrome (PCOS); however, the specific mechanism is still unclear. OBJECTIVE: To investigate the effect of sodium aescinate (SA) on PCOS-IR rat models. METHODS: Sixty rats were randomly divided into the five groups: un-treated rats (n = 12), PCOS-IR group (n = 12), PCOS-IR group plus 50 mg/kg SA (n = 12), PCOS-IR group plus 10 mg/kg SA (n = 12), PCOS-IR group plus 150 mg/kg metformin (n = 12)...
2017: Bratislavské Lekárske Listy
https://www.readbyqxmd.com/read/28469096/protective-effects-of-curcumin-against-sodium-arsenite-induced-ovarian-oxidative-injury-in-a-mouse-model
#18
Xiao-Ning Wang, Chang-Jun Zhang, Hong-Lu Diao, Ying Zhang
BACKGROUND: Excessive reactive oxygen species (ROS) may lead to a number of reproductive diseases such as polycystic ovary syndrome. This study aimed to establish an animal model of ovarian oxidative stress and to assess the protective effect of curcumin against oxidative injury. METHODS: Ovarian oxidative stress was induced in female Kunming mice (n = 40) with intraperitoneal injection of 8 mg/kg sodium arsenite (As) once every other day for 16 days; meanwhile, they were, respectively, treated by intragastric administration of 0, 100, 150, or 200 mg/kg (n = 10/group) curcumin once per day for 21 days...
May 5, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28463030/use-of-cyproterone-acetate-ethinylestradiol-in-polycystic-ovary-syndrome-rationale-and-practical-aspects
#19
X Ruan, A Kubba, A Aguilar, A O Mueck
INTRODUCTION: Polycystic ovary syndrome (PCOS) is a common, heterogeneous disorder characterised by hyperandrogenic skin symptoms, irregular menstruation and subfertility, increased risk of endometrial malignancy, and increased risk of preventable diseases associated with metabolic syndrome. Cyproterone acetate (CPA) 2 mg, combined with ethinylestradiol (EE) 35 μg, is indicated for the treatment of moderate to severe acne related to androgen-sensitivity (with or without seborrhea) and/or hirsutism, in women of reproductive age...
May 2, 2017: European Journal of Contraception & Reproductive Health Care
https://www.readbyqxmd.com/read/28462131/effect-of-combination-of-withania-somnifera-dunal-and-tribulus-terrestris-linn-on-letrozole-induced-polycystic-ovarian-syndrome-in-rats
#20
Amrin Saiyed, Nasreen Jahan, Shaikh Ajij Ahmed Makbul, Mushir Ansari, Humaira Bano, Syeda Hajera Habib
BACKGROUND: To investigate the effect of the combination of hydroalcoholic extract of Withania somnifera (WS) and Tribulus terrestris (TT) on letrozole induced polycystic ovarian syndrome (PCOS) in rat. METHODS: Twenty four female Wistar rats of regular estrus cycle were divided into four groups of six animals each. The negative control group received 1 mL of 0.5% carboxy methyl cellulose. The animals of the other groups were treated with letrozole (1 mg/kg) for 21 days for induction of PCOS...
December 2016: Integr Med Res
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