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https://www.readbyqxmd.com/read/30343562/the-kv7-channel-activator-retigabine-induces-vasorelaxation-via-an-endothelial-independent-pathway-in-male-mouse-aorta
#1
Hyun Namgoong, Chaeeun Cho, Sewon Lee
PURPOSE: Previous studies have indicated that Kv7 channels have an important role in the regulation of blood vessel reactivity, including in the coronary, renal, and cerebral arteries. The present studies examined whether Kv7 channels regulated vascular reactivity in the mouse aorta and investigated the mechanisms involved in the reactivity. METHODS: Wild-type (WT) male C57BL/6 mice, between 10 and 15 weeks old, were used in this study. The vascular function of the aorta in WT male mice was assessed by using a pin myography system (Model 620; DMT, Denmark)...
September 30, 2018: Journal of Exercise Nutrition & Biochemistry
https://www.readbyqxmd.com/read/30343554/the-effects-of-coenzyme-q10-on-oxidative-stress-and-heat-shock-proteins-in-rats-subjected-to-acute-and-chronic-exercise
#2
Ragip Pala, Fahrettin Beyaz, Mehmet Tuzcu, Besir Er, Nurhan Sahin, Vedat Cinar, Kazim Sahin
PURPOSE: The aim of the study was to determine the effects of dietary CoQ10 on serum biochemical parameters, lipid peroxidation, and HSP expression in the liver and slow-twitch muscles (soleus and gastronemius deep portion) of exercise-trained rats. METHODS: A total of 42 Wistar albino rats were divided into six groups: 1) Control, 2) Coenzyme Q10 (CoQ10), 3) Chronic Exercise (CE), 4) CE + CoQ10, 5) Acute Exercise (AE), and 6) AE + CoQ10. The rats were subjected to the running test 5 days a week for 6 weeks after which CoQ10 was administered via the diet...
September 30, 2018: Journal of Exercise Nutrition & Biochemistry
https://www.readbyqxmd.com/read/30343553/ginseng-berry-extract-increases-nitric-oxide-level-in-vascular-endothelial-cells-and-improves-cgmp-expression-and-blood-circulation-in-muscle-cells
#3
Cho In-Ho, Kang Byung-Woo, Park Yun-Jae, Lee Han-Joo, Park Sok, Lee Namju
PURPOSE: The purpose of this study was to determine whether ginseng berry extract improves blood circulation by regulating vasodilator expression in exposed to tumor necrosis factor alpha (TNF-α)-exposed endothelial cells and muscle cells. METHODS: Nitric oxide (NO) and cGMP levels in human umbilical vein endothelial cells (HUVECs) and A7r5 cells exposed to ginseng berry extract were investigated. Based on the in vitro results, healthy participants were treated with ginseng berry extract for 4 weeks and then a non-invasive vascular screening device was used to confirm the improvement of blood circulation...
September 30, 2018: Journal of Exercise Nutrition & Biochemistry
https://www.readbyqxmd.com/read/30343524/pediatric-quality-of-life-inventory-pedsql-3-2-diabetes-module-for-youth-with-type-2-diabetes-reliability-and-validity
#4
J W Varni, A M Delamater, K K Hood, J K Raymond, N T Chang, K A Driscoll, J C Wong, J P Yi-Frazier, E K Grishman, M A Faith, S D Corathers, J C Kichler, J L Miller, E M Doskey, V P Aguirre, R W Heffer, D P Wilson
AIM: To test the measurement properties of the revised and updated Pediatric Quality of Life Inventory (PedsQL) 3.2 Diabetes Module originally developed in Type 1 diabetes in youth with Type 2 diabetes. METHODS: The PedsQL 3.2 Diabetes Module and PedsQL Generic Core Scales were administered in a field test study to 100 young people aged 9-25 years with Type 2 diabetes. Factor analysis was conducted to determine the factor structure of the items. RESULTS: The 15-item Diabetes Symptoms Summary Score and 12-item Type 2-specific Diabetes Management Summary Score were empirically derived through factor analysis...
October 21, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/30343522/population-general-practitioner-and-practice-characteristics-are-associated-with-screening-procedures-for-microvascular-complications-in-type-2-diabetes-care-in-norway
#5
Å Bakke, A T Tran, I Dalen, J G Cooper, K F Løvaas, A K Jenum, T J Berg, T V Madsen, K Nøkleby, B Gjelsvik, T Claudi, S Skeie, S Carlsen, S Sandberg, G Thue
AIMS: To assess population, general practitioner (GP) and practice characteristics associated with the performance of microvascular screening procedures and to propose strategies to improve Type 2 diabetes care. METHODS: A cross-sectional survey in Norway (281 GPs from 77 practices) identified 8246 people with a Type 2 diabetes duration of 1 year or more. We used multilevel regression models with either the recording of at least two of three recommended screening procedures (albuminuria, monofilament, eye examination) or each procedure separately as dependent variable (yes/no), and characteristics related to the person with diabetes, GP or practice as independent variables...
October 21, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/30343516/dialysate-sodium-concentration-the-forgotten-salt-shaker
#6
Norio Hanafusa, Ken Tsuchiya, Kosaku Nitta
The concentration of sodium in dialysis fluid, a major determinant of extracellular fluid volume and blood pressure, plays a major role in the sodium balance in end-stage renal disease patients. A low dialysate sodium concentration (DNa) reduces interdialytic weight gain (IDWG) and blood pressure and might help ameliorate endothelial dysfunction and inflammation. However, low DNa can also increase the incidence of hypotensive episodes and muscle cramps. Sodium profiling, as typically prescribed in which the DNa is ramped up from above 140 mEq/L to nonphysiological levels, might reduce hypotension in patients with hemodynamic instability but at the cost of the consequences of hypernatremia...
October 21, 2018: Seminars in Dialysis
https://www.readbyqxmd.com/read/30343506/pancreatic-endocrine-like-cells-differentiated-from-human-umbilical-cords-wharton-s-jelly-mesenchymal-stem-cells-using-small-molecules
#7
Sharath Belame Shivakumar, Dinesh Bharti, Raghavendra Baregundi Subbarao, Ju-Mi Park, Young-Bum Son, Imran Ullah, Yong-Ho Choe, Hyeong-Jeong Lee, Bong-Wook Park, Sung-Lim Lee, Gyu-Jin Rho
Following success of pancreatic islet transplantation in the treatment of Type I diabetes mellitus, there is a growing interest in using cell-based treatment approaches. However, severe shortage of donor islets-pancreas impeded the growth, and made researchers to search for an alternative treatment approaches. In this context, recently, stem cell-based therapy has gained more attention. The current study demonstrated that epigenetic modification improves the in vitro differentiation of Wharton's jelly mesenchymal stem cells (WJMSCs) into pancreatic endocrine-like cells...
October 21, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/30343492/long-term-comparative-safety-analysis-of-the-risks-associated-with-adding-or-switching-to-a-sulfonylurea-as-second-line-type-2-diabetes-mellitus-treatment-in-a-us-veterans-affairs-population
#8
W R Powell, C L Christiansen, D R Miller
AIM: To examine the risks of all-cause mortality and cardiovascular events associated with adding vs switching to second-line therapies in a comparative safety study of people with Type 2 diabetes mellitus. METHODS: We conducted a retrospective cohort study using an as-treated analysis of people served by the Veterans Health Administration who were on metformin and subsequently augmented this treatment or switched to other oral glucose-lowering treatments between 1998 and 2012...
October 21, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/30343489/automated-symptom-and-treatment-side-effect-monitoring-for-improved-quality-of-life-among-adults-with-diabetic-peripheral-neuropathy-in-primary-care-a-pragmatic-cluster-randomized-controlled-trial
#9
A S Adams, J A Schmittdiel, A Altschuler, E A Bayliss, R Neugebauer, L Ma, W Dyer, J Clark, B Cook, D Willyoung, M Jaffe, J D Young, E Kim, J M Boggs, L Prosser, E Wittenberg, B Callaghan, M Shainline, R M Hippler, R W Grant
AIMS: To evaluate the effectiveness of automated symptom and side effect monitoring on quality of life among individuals with symptomatic diabetic peripheral neuropathy. METHODS: We conducted a pragmatic, cluster randomized controlled trial (July 2014 to July 2016) within a large healthcare system. We randomized 1834 primary care physicians and prospectively recruited from their lists 1270 individuals with neuropathy who were newly prescribed medications for their symptoms...
October 21, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/30343482/effects-of-dietary-zinc-on-carcass-traits-meat-quality-antioxidant-status-and-tissue-zinc-accumulation-of-pekin-ducks
#10
Min Wen, Bing Wu, Hua Zhao, Guangmang Liu, Xiaoling Chen, Gang Tian, Jingyi Cai, Gang Jia
This study investigated the effects of dietary zinc on carcass traits, meat quality, antioxidant capacity, and tissue zinc accumulation of Pekin ducks. A total of 768 1-day-old Pekin ducks were randomly allocated to six dietary treatments and penned in groups of 16 with 8 pens per treatment. Ducks were fed a basal corn-soybean meal diet supplemented with graded levels of zinc sulfate (0, 15, 30, 60, 120, 240 mg zinc/kg) for 35 days. The slaughter weight, carcass weight, eviscerated weight, and breast and leg muscle weight of Pekin ducks were increased with increasing dietary zinc levels (P < 0...
October 20, 2018: Biological Trace Element Research
https://www.readbyqxmd.com/read/30343471/comparison-of-cfr-peek-and-conventional-titanium-locking-plates-for-proximal-humeral-fractures-a-retrospective-controlled-study-of-patient-outcomes
#11
A Padolino, G Porcellini, B Guollo, E Fabbri, G N Kiran Kumar, P Paladini, G Merolla
BACKGROUND: Metal plates are the fixation devices used most frequently to proximal humeral fractures (PHFs). However, in recent years carbon fiber-reinforced polyetheretherketone (CFR-PEEK) plates have become increasingly common. This study compares the clinical and radiographic outcomes of 42 Neer three- and four-part PHFs treated with CFR-PEEK or metal (titanium) plates. MATERIALS AND METHODS: Forty-two PHF patients were managed with CFR-PEEK plates (n = 21, males/females 9/12; mean age 57...
October 2018: Musculoskeletal Surgery
https://www.readbyqxmd.com/read/30343468/diabetic-cardiomyopathy-modelling-using-induced-pluripotent-stem-cell-derived-cardiomyocytes-recent-advances-and-emerging-models
#12
REVIEW
Cecilia Granéli, Ryan Hicks, Gabriella Brolén, Jane Synnergren, Peter Sartipy
The global burden of diabetes has drastically increased over the past decades and in 2017 approximately 4 million deaths were caused by diabetes and cardiovascular complications. Diabetic cardiomyopathy is a common complication of diabetes with early manifestations of diastolic dysfunction and left ventricular hypertrophy with subsequent progression to systolic dysfunction and ultimately heart failure. An in vitro model accurately recapitulating key processes of diabetic cardiomyopathy would provide a useful tool for investigations of underlying disease mechanisms to further our understanding of the disease and thereby potentially advance treatment strategies for patients...
October 20, 2018: Stem Cell Reviews
https://www.readbyqxmd.com/read/30343467/anti-gad-antibodies-and-the-cerebellum-where-do-we-stand
#13
EDITORIAL
Mario Manto, Hiroshi Mitoma, Christiane S Hampe
Anti-GAD65 antibodies (anti-GAD65 Abs) are associated with cerebellar ataxia (CA). The significance of anti-GAD65 Abs has been a focus of debates. Since GAD65 is intracellularly located and associated with type 1 diabetes mellitus and different clinical neurological phenotypes such as CA, stiff-person syndrome, and epilepsy, some researchers have argued that anti-GAD65 Abs have no pathogenic roles. On the other hand, recent physiological studies in vitro and in vivo have elucidated that binding of GAD65 by anti-GAD65 Abs elicits loss of GAD65 functions pertaining GABA release with an epitope dependence, leading to the development of CA...
October 20, 2018: Cerebellum
https://www.readbyqxmd.com/read/30343446/an-update-on-the-role-of-rankl-rank-osteoprotegerin-and-wnt-%C3%A3-catenin-signaling-pathways-in-pediatric-diseases
#14
Giacomina Brunetti, Gabriele D'Amato, Mariangela Chiarito, Apollonia Tullo, Graziana Colaianni, Silvia Colucci, Maria Grano, Maria Felicia Faienza
BACKGROUND: Bone remodeling is a lifelong process due to the balanced activity of osteoclasts (OCs), the bone-reabsorbing cells, and osteoblasts (OBs), and the bone-forming cells. This equilibrium is regulated by numerous cytokines, but it has been largely demonstrated that the RANK/RANKL/osteoprotegerin and Wnt/β-catenin pathways play a key role in the control of osteoclastogenesis and osteoblastogenesis, respectively. The pro-osteoblastogenic activity of the Wnt/β-catenin can be inhibited by sclerostin and Dickkopf-1 (DKK-1)...
October 20, 2018: World Journal of Pediatrics: WJP
https://www.readbyqxmd.com/read/30343445/a-review-of-data-of-findings-on-night-shift-work-and-the-development-of-dm-and-cvd-events-a-synthesis-of-the-proposed-molecular-mechanisms
#15
REVIEW
S Strohmaier, E E Devore, Y Zhang, E S Schernhammer
PURPOSE OF REVIEW: Night shift work has become highly prevalent in our 24/7 societies, with up to 18% of the US work force working alternate shift schedules. However, studies indicate that there may be adverse health effects of chronic night work across diverse populations. These effects are likely due to misalignment of the circadian system with work schedules, mediated by the system's primary marker melatonin as well as other downstream molecules. RECENT FINDINGS: Melatonin has multiple biologic actions that are relevant to cardiometabolic disease, including modulation of oxidative stress, inflammation, and (via the melatonin receptor) vasoconstriction...
October 20, 2018: Current Diabetes Reports
https://www.readbyqxmd.com/read/30343423/who-will-win-induced-pluripotent-stem-cells-versus-embryonic-stem-cells-for-%C3%AE-cell-replacement-and-diabetes-disease-modeling
#16
REVIEW
Elena F Jacobson, Emmanuel S Tzanakakis
PURPOSE OF REVIEW: Ever since the reprogramming of human fibroblasts to induced pluripotent stem cells (hiPSCs), scientists have been trying to determine if hiPSCs can give rise to progeny akin to native terminally differentiated cells as human embryonic stem cells (hESCs) do. Many different somatic cell types have been successfully reprogrammed via a variety of methods. In this review, we will discuss recent studies comparing hiPSCs and hESCs and their ability to differentiate to desired cell types as well as explore diabetes disease models...
October 20, 2018: Current Diabetes Reports
https://www.readbyqxmd.com/read/30343414/ten-years-of-follow-up-of-bilio-intestinal-bypass-is-malabsorption-necessary-for-long-term-metabolic-results
#17
Antonio Vitiello, Pilone Vincenzo, Antonio Formato, Giuliano Izzo, Luca Ferraro, Pietro Forestieri
BACKGROUND: Bilio-intestinal bypass (BIBP) is an uncommon bariatric procedure. In 1999, a prospective trial was started at our institution to evaluate the effectiveness of BIBP. Trial was interrupted in 2006 due to high rate of complications. The aim of the present paper was to retrospectively review 10-year outcomes of BIBP. METHODS: Retrospective review of bariatric database was performed to find patients that had undergone BIBP from 1999 to 2006. Data collected were as follows: age, gender, body weight, body mass index (BMI), percentage of excess weight loss (%EWL), remission from weight-related diseases, complications, and deaths at 1,3, 5, 7, and 10 years...
October 20, 2018: Langenbeck's Archives of Surgery
https://www.readbyqxmd.com/read/30343407/the-effects-of-resveratrol-metformin-cold-and-strength-training-on-the-level-of-perilipin-5-in-the-heart-skeletal-muscle-and-brown-adipose-tissues-in-mouse
#18
Fadaei Mehdi, Ghatreh Samani Keihan, Amini Seyed Asadollah, Farrokhi Effat
The high accumulation of lipid droplets in the cell is related to metabolic disorders, such as obesity. Perilipin 5 (Plin5), plays an important role in triglyceride hydrolysis in the lipid droplets. In this study, this protein has been evaluated in different tissues and conditions in mice. Fifty male mice were divided into 5 groups and treated for 45 days with Resveratrol, Metformin, strength training, and 4 °C cold. Brown adipose tissue (BAT), gastrocnemius skeletal muscle and heart were isolated for RNA extraction...
October 20, 2018: Cell Biochemistry and Biophysics
https://www.readbyqxmd.com/read/30343402/proteinuria-is-an-independent-predictor-of-rapid-progression-of-mild-to-moderate-aortic-stenosis-in-patients-with-preserved-renal-function
#19
You-Jung Choi, Jun-Bean Park, In-Chang Hwang, Seung-Pyo Lee, Hyung-Kwan Kim, Yong-Jin Kim, Dae-Won Sohn
Although proteinuria is a well-known risk factor for cardiovascular disease, its relationship with the progression of aortic stenosis (AS) has not been established. Our aim was to investigate the relationship between proteinuria (detected by urine dipstick test) and AS progression (assessed by the annualized reduction rate of aortic valve area [AVA]). A total of 460 patients with mild to moderate AS (defined by a peak velocity of 2.0-4.0 m/s) without end-stage renal disease who underwent two echocardiograms at least 3 months apart were included...
October 20, 2018: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/30343400/treatment-of-muscle-injuries-with-platelet-rich-plasma-a-review-of-the-literature
#20
REVIEW
Kian Setayesh, Arturo Villarreal, Andrew Gottschalk, John M Tokish, W Stephen Choate
PURPOSE OF REVIEW: This review discusses the current literature regarding the use of platelet-rich plasma (PRP) in the treatment of muscle strain injuries. Case series as well as experimental trials for both human and animal models are covered. RECENT FINDINGS: Multiple studies have examined outcomes for the use of PRP in the treatment of muscle strain injuries. PRP has been shown to promote muscle recovery via anabolic growth factors released from activated platelets, and in doing so, potentially reduces pain, swelling, and time for return to play...
October 20, 2018: Current Reviews in Musculoskeletal Medicine
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