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https://www.readbyqxmd.com/read/29779364/swing-door-overlay-tympanoplasty-surgical-technique-and-outcomes
#1
So Young Park, Hyuk Jae Lee, Myung Joo Shim, Dong Kee Kim, Byung Do Suh, Shi Nae Park
Objectives: The classical overlay tympanoplasty is technically difficult with some disadvantages and thus less popular. However, it is particularly useful for large, anterior perforations. In this study, we describe the technique of a modified overlay graft in the tympanoplasty coined as the swing-door overlay tympanoplasty and report its outcomes. Methods: Retrospective review of patients undergoing the swing-door overlay tympanoplasty at a tertiary referral center between 2003 and 2016 was performed...
May 22, 2018: Clinical and Experimental Otorhinolaryngology
https://www.readbyqxmd.com/read/29769265/reciprocal-negative-regulation-between-lmx1a-and-lmo4-is-required-for-inner-ear-formation
#2
Yanhan Huang, Jennifer Hill, Andrew Yatteau, Loksum Wong, Tao Jiang, Jelena Petrovic, Lin Gan, Lijin Dong, Doris K Wu
LIM-domain containing transcription factors (LIM-TFs) are conserved factors important for embryogenesis. The specificity of these factors in transcriptional regulation is conferred by the complexes they form with other proteins such as LIM-domain-binding (Ldb) proteins and LIM-domain only (LMO) proteins. Unlike LIM-TF, these proteins do not bind DNA directly. LMO are negative regulators of LIM-TF and they function by competing with LIM-TFs for binding to Ldbs. Although the LIM-TF Lmx1a is expressed in the developing mouse hindbrain, which provides many of the extrinsic signals for inner ear formation, conditional knockout embryos of both sexes show that the inner ear source of Lmx1a is the major contributor of ear patterning...
May 16, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29736264/clinical-management-of-friedreich-s-ataxia-a-report-of-two-cases
#3
Yannis Dionyssiotis, Athina Kapsokoulou, Anna Danopoulou, Maria Kokolaki, Athina Vadalouka
Introduction: Friedreich's ataxia (FDRA) is the most common autosomal recessive, early-onset ataxia. FDRA is a progressive neurodegenerative disease that mainly affects the posterior (dorsal) columns of the spinal cord resulting in sensory ataxia. It manifests in initial symptoms of poor coordination and gait disturbance. Case presentation: We present two cases, a brother (54 years old) and sister (56 years old), with FDRA that are chronically institutionalized for incomplete quadriplegia without spasticity...
2018: Spinal Cord Series and Cases
https://www.readbyqxmd.com/read/29716524/cochlear-morphology-in-the-developing-inner-ear-of-the-porcine-model-of-spontaneous-deafness
#4
Wei Chen, Qing-Qing Hao, Li-Li Ren, Wei Ren, Hui-Sang Lin, Wei-Wei Guo, Shi-Ming Yang
BACKGROUND: Auditory function and cochlear morphology have previously been described in a porcine model with spontaneous WS2-like phenotype. In the present study, cochlear histopathology was further investigated in the inner ear of the developing spontaneous deafness pig. RESULTS: We found that the stria vascularis transformed into a complex tri-laminar tissue at embryonic 85 days (E85) in normal pigs, but not in the MITF-/- pigs. As the neural crest (NC) of cochlea was derived by melanocytes...
May 2, 2018: BMC Neuroscience
https://www.readbyqxmd.com/read/29673835/effects-of-ovarian-reserve-and-hormone-therapy-on-hearing-in-premenopausal-and-postmenopausal-women-a-cross-sectional-study
#5
Jingfei Zhang, Tingyue Zhang, Lisheng Yu, Qianying Ruan, Lingxue Yin, Dong Liu, Haicheng Zhang, Wenpei Bai, Zhenghong Ren
OBJECTIVES: To observe the hearing function around menopause, to analyze the effects of ovarian reserve and hormone therapy on hearing, and to study factors related to hearing loss among women around menopause. STUDY DESIGN: In this cross-sectional study, we evaluated 109 women around menopause aged 45-55 years, including 40 women with ovarian failure, 48 with ovarian non-failure, and 21 receiving hormone therapy. All women underwent an audiologic evaluation, and hormone blood testing was performed...
May 2018: Maturitas
https://www.readbyqxmd.com/read/29667168/cognitive-decline-and-older-driver-crash-risk
#6
Laura A Fraade-Blanar, Beth E Ebel, Eric B Larson, Jeanne M Sears, Hilaire J Thompson, Kwun Chuen G Chan, Paul K Crane
OBJECTIVES: To examine automobile crash risk associated with cognition in older drivers without dementia. DESIGN: Retrospective secondary analysis of longitudinal cohort study. SETTING: Our study used data from the Adult Changes in Thought (ACT) Study merged with Washington State crash reports and licensure records. Data were available from 2002 to 2015. PARTICIPANTS: Group Health enrollees from Washington State aged 65 and older with active driver's licenses (N=2,615)...
April 17, 2018: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29651401/rehabilitation-of-an-auricular-defect-using-surgical-stent
#7
Mahnaz Arshad, Gholamreza Shirani, Sina Refoua
Reconstruction of a facial defect is a complex modality either surgically or prosthetically, depending on the site, size, etiology, severity, age, and the patient's expectation. The loss of an auricle, in the presence of an auditory canal, affects hearing, because the auricle gathers sound and directs it into the canal. The auricle acts as a resonator to slightly amplify lower frequency sounds and helps to localize sounds, especially in conjunction with the other ear. Osseointegrated implants have an important role in the prosthetic reconstruction of patients with craniofacial defects...
January 2018: World Journal of Plastic Surgery
https://www.readbyqxmd.com/read/29625343/rapid-exhaustion-of-auditory-neural-conduction-in-a-prototypical-mitochondrial-disease-friedreich-ataxia
#8
Fabrice Giraudet, Perrine Charles, Thierry Mom, Odile Boespflug-Tanguy, Alexandra Dürr, Paul Deltenre, Paul Avan
OBJECTIVES: In patients with Friedreich ataxia (FRDA), mitochondrial failure leads to impaired cellular energetics. Since many FRDA patients have impaired hearing in noise, we investigated the objective consequences on standard auditory brainstem-evoked responses (ABRs). METHODS: In 37 FRDA patients, among whom 34 with abnormal standard ABRs, hearing sensitivity, speech-in-noise intelligibility and otoacoustic emissions were controlled. ABR recordings were split into four consecutive segments of the total time frame used for data collection, thus allowing the dynamics of ABR averaging to be observed...
March 27, 2018: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/29602593/effect-of-age-and-hearing-loss-on-auditory-stream-segregation-of-speech-sounds
#9
Marion David, Alexis N Tausend, Olaf Strelcyk, Andrew J Oxenham
Segregating and understanding speech in complex environments is a major challenge for hearing-impaired (HI) listeners. It remains unclear to what extent these difficulties are dominated by direct interference, such as simultaneous masking, or by a failure of the mechanisms of stream segregation. This study compared older HI listeners' performance with that of young and older normal-hearing (NH) listeners in stream segregation tasks involving speech sounds. Listeners were presented with sequences of speech tokens, each consisting of a fricative consonant and a voiced vowel (CV)...
March 21, 2018: Hearing Research
https://www.readbyqxmd.com/read/29600740/sensitivity-and-specificity-analysis-use-of-emoticon-for-screening-of-depression-in-elderly-in-singapore
#10
Laurence Tan, Hui Jin Toh, Lai Kiow Sim, James Alvin Low
BACKGROUND: The current screening tools for depression can be tedious to administer, especially in the elderly population with hearing impairment and/or limited proficiency in English language. OBJECTIVES: To look at the feasibility of using emoticon as a screening and assessment tool for depression in the elderly. DESIGN: Cross-sectional study. METHOD: A total of 77 elderly patients completed the study from June 2014 to August 2015 in a general geriatric outpatient clinic of an acute care hospital in Singapore...
March 1, 2018: Journal of the American Psychiatric Nurses Association
https://www.readbyqxmd.com/read/29594077/results-of-type-i-tympanoplasty-using-fascia-with-or-without-cartilage-reinforcement-10-years-experience
#11
Ali Kouhi, Mohammad Taghi Khorsandi Ashthiani, Mir Mohammad Jalali
Introduction: There remains controversy about the optimal kind of graft to repair tympanic membrane. The purpose of this study was to evaluate the anatomical and auditory outcomes of type I tympanoplasty using fascia with or without cartilage reinforcement. Materials and Methods: This retrospective cohort study was conducted from 2005 to 2015. All cases were surgically treated by a single surgeon. We excluded cases in which the etiology of chronic otitis media was cholesteatoma...
March 2018: Iranian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/29553961/overcoming-developing-world-challenges-in-cochlear-implantation-a-south-american-perspective
#12
Ricardo F Bento, Fayez Bahmad, Miguel A Hippolyto, Sady S Da Costa
PURPOSE OF REVIEW: Effective hearing rehabilitation with cochlear implantation is challenging in developing countries, and this review focuses on strategies for childhood profound sensorineural hearing loss care in South America. RECENT FINDINGS: Most global hearing loss exists in developing countries; optimal cost-effective management strategies are essential in these environments. This review aims to assess and discuss the challenges of cochlear implantation effectiveness in South America...
June 2018: Current Opinion in Otolaryngology & Head and Neck Surgery
https://www.readbyqxmd.com/read/29552692/causes-of-hyperhomocysteinemia-and-its-pathological-significance
#13
REVIEW
Jihyun Kim, Hyunhee Kim, Heewon Roh, Youngjoo Kwon
In the last 10 years, homocysteine has been regarded as a marker of cardiovascular disease and a definite risk factor for many other diseases. Homocysteine is biosynthesized from methionine through multiple steps and then goes through one of two major metabolic pathways: remethylation and transsulfuration. Hyperhomocysteinemia is a state in which too much homocysteine is present in the body. The main cause of hyperhomocysteinemia is a dysfunction of enzymes and cofactors associated with the process of homocysteine biosynthesis...
April 2018: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/29546771/newly-diagnosed-meniere-s-disease-clinical-course-with-initiation-of-noninvasive-treatment-including-an-accounting-of-vestibular-migraine
#14
Firas Sbeih, Florian Christov, Michael B Gluth
OBJECTIVE: To describe the course of Meniere's disease with noninvasive treatment during the first few years after initial diagnosis. METHODS: A retrospective review of consecutive patients with newly diagnosed definite Meniere's disease between 2013 and 2016 and a minimum follow-up of 1 year. Patients received a written plan for low sodium, water therapy, and treatment with a diuretic and/or betahistine. Subjects were screened and treated for vestibular migraine as needed...
May 2018: Annals of Otology, Rhinology, and Laryngology
https://www.readbyqxmd.com/read/29540340/mecom-associated-syndrome-a-heterogeneous-inherited-bone-marrow-failure-syndrome-with-amegakaryocytic-thrombocytopenia
#15
Manuela Germeshausen, Phil Ancliff, Jaime Estrada, Markus Metzler, Eva Ponstingl, Horst Rütschle, Dirk Schwabe, Richard H Scott, Sule Unal, Angela Wawer, Bernward Zeller, Matthias Ballmaier
Heterozygous mutations in MECOM (MDS1 and EVI1 complex locus) have been reported to be causative of a rare association of congenital amegakaryocytic thrombocytopenia and radioulnar synostosis. Here we report on 12 patients with congenital hypomegakaryocytic thrombocytopenia caused by MECOM mutations (including 10 novel mutations). The mutations affected different functional domains of the EVI1 protein. The spectrum of phenotypes was much broader than initially reported for the first 3 patients; we found familial as well as sporadic cases, and the clinical spectrum ranged from isolated radioulnar synostosis with no or mild hematological involvement to severe bone marrow failure without obvious skeletal abnormality...
March 27, 2018: Blood Advances
https://www.readbyqxmd.com/read/29533410/patient-was-wrongly-diagnosed-and-repeatedly-treated-for-immune-thrombocytopenia-for-50-years
#16
Honar Cherif, Andreas Greinacher, Norbert Lubenow
We report on a patient with inherited macrothrombocytopenia, MYH9 related disease (MYH9-RD). The patient was wrongly diagnosed and repeatedly treated for immune thrombocytopenia (ITP) for nearly 50 years. Cases of misdiagnosed MYH9-RD and other hereditary thrombocytopenias have been described previously. Typical clinical features such as renal failure and/or progressive loss of hearing should give grounds to suspect hereditary thrombocytopenia. Initial laboratory diagnosis can start with a simple blood smear followed by immunohistochemistry and genotyping...
March 13, 2018: Läkartidningen
https://www.readbyqxmd.com/read/29510278/microvascular-decompression-for-classical-trigeminal-neuralgia-caused-by-venous-compression-novel-anatomic-classifications-and-surgical-strategy
#17
Min Wu, Xianming Fu, Ying Ji, Wanhai Ding, Dali Deng, Yehan Wang, Xiaofeng Jiang, Chaoshi Niu
BACKGROUND: Microvascular decompression of the trigeminal nerve is the most effective treatment for trigeminal neuralgia. However, when encountering classical trigeminal neuralgia caused by venous compression, the procedure becomes much more difficult, and failure or recurrence because of incomplete decompression may become frequent. This study aimed to investigate the anatomic variation of the culprit veins and discuss the surgical strategy for different types. METHODS: We performed a retrospective analysis of 64 consecutive cases in whom veins were considered as responsible vessels alone or combined with other adjacent arteries...
May 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29504491/unbound-bilirubin-measurements-by-a-novel-probe-in-preterm-infants
#18
Thomas Hegyi, Alan Kleinfeld, Andrew Huber, Barry Weinberger, Naureen Memon, Weichung Shih, Mary Carayannopoulos, William Oh
BACKGROUND: Hyperbilirubinemia occurs in over 80% of newborns and severe bilirubin toxicity can lead to neurological dysfunction and death, especially in preterm infants. Currently, the risk of bilirubin toxicity is assessed by measuring the levels of total serum bilirubin (TSB), which are used to direct treatments including immunoglobulin administration, phototherapy, and exchange transfusion. However, free, unbound bilirubin levels (Bf) predict the risk of bilirubin neurotoxicity more accurately than TSB...
March 12, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29501290/population-based-cross-sectional-study-to-assess-newborn-hearing-screening-program-in-central-germany
#19
Anke Rissmann, Andrea Koehn, Marja Loderstedt, Cornelia Schwemmle, Gerrit Goetze, Sylva Bartel, Stefan K Plontke, Joerg Langer, Klaus Begall, Peter Matulat, Friedrich-Wilhelm Roehl, Ulrich Vorwerk
OBJECTIVES: Airway management during adenoidectomy is traditionally performed through endotracheal intubation (ETT). Laryngeal mask airway (LMA) may be less stimulating to the airway and allow for shorter overall operating room time. Previous studies report LMA use during adenotonsillectomy with conversion rates to ETT of up to 17%. There has been no prior evaluation of LMA use during adenoidectomy alone. In this study, we attempt to identify the rate and contributing factors of LMA failure during adenoidectomy...
April 2018: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/29496369/cochlear-implant-revision-surgeries-in-children
#20
Maria Stella Arantes do Amaral, Ana Cláudia Mirândola B Reis, Eduardo T Massuda, Miguel Angelo Hyppolito
INTRODUCTION: The surgery during which the cochlear implant internal device is implanted is not entirely free of risks and may produce problems that will require revision surgeries. OBJECTIVE: To verify the indications for cochlear implantation revision surgery for the cochlear implant internal device, its effectiveness and its correlation with certain variables related to language and hearing. METHODS: A retrospective study of patients under 18 years submitted to cochlear implant Surgery from 2004 to 2015 in a public hospital in Brazil...
February 16, 2018: Brazilian Journal of Otorhinolaryngology
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