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https://www.readbyqxmd.com/read/28631523/the-association-among-prematurity-cochlear-hyperintensity-and-hearing-loss
#1
Michael A Wien, Matthew T Whitehead
Background Prematurity is a major risk factor for neonatal hearing loss. Recent advancements in magnetic resonance imaging (MRI) have made it possible to evaluate structural details of the membranous labyrinths in premature infants that have heretofore been inaccessible. Objective We compared the prevalence of abnormal cochlear signal intensity in premature and term neonates and evaluated for a potential link with hearing loss. Materials and methods We retrospectively reviewed 148 consecutive MR exams performed in premature (< 37 weeks' gestation) and term neonates performed over a 30-month period...
January 1, 2017: Neuroradiology Journal
https://www.readbyqxmd.com/read/28623942/the-palisade-cartilage-tympanoplasty-technique-a-systematic-review-and-meta-analysis
#2
REVIEW
Caroline C Jeffery, Cameron Shillington, Colin Andrews, Allan Ho
BACKGROUND: Tympanoplasty is a common procedure performed by Otolaryngologists. Many types of autologous grafts have been used with variations of techniques with varying results. This is the first systematic review of the literature and meta-analysis with the aim to evaluate the effectiveness of one of the techniques which is gaining popularity, the palisade cartilage tympanoplasty. PubMed, EMBASE, and Cochrane databases were searched for "palisade", "cartilage", "tympanoplasty", "perforation" and their synonyms...
June 17, 2017: Journal of Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28602153/frailty-as-a-predictor-of-mortality-in-the-elderly-emergency-general-surgery-patient
#3
Jens Goeteyn, Louis A Evans, Siem De Cleyn, Sigrid Fauconnier, Caroline Damen, Jonathan Hewitt, Wim Ceelen
BACKGROUND: The number of surgical procedures performed in elderly and frail patients has greatly increased in the last decades. However, there is little research in the elderly emergency general surgery patient. The aim of this study was to assess the prevalence of frailty in the emergency general surgery population in Belgium. Secondly, we examined the length of hospital stay, readmission rate and mortality at 30 and 90 days. METHODS: We conducted a prospective observational study at Ghent University Hospital...
June 10, 2017: Acta Chirurgica Belgica
https://www.readbyqxmd.com/read/28601902/titanium-incus-interposition-ossiculoplasty-audiological-outcomes-and-extrusion-rates
#4
Selcuk Mulazimoglu, Alexander Saxby, Christoph Schlegel, Thomas Linder
This study aimed to evaluate the benefit but also the extrusions, dislocations, and failures of a titanium incus prosthesis along with the long-term audiological outcomes. We prospectively collected data from 139 patients undergoing ossiculoplasty using the Fisch titanium incus prosthesis between 2001 and 2016. Overall, 126 patients with at least 6 months of follow-up (mean 4.5 years, range 6-155 months) were analyzed. Patients were grouped as "extrusion" (n = 9, 7%) if the prosthesis extruded, "failure" (n = 22, 18%) if a reoperation was needed concerning the prosthesis, and "stable" (n = 95, 75%) if the prosthesis remained functional in the middle ear...
June 10, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28599119/dendrites-enable-a-robust-mechanism-for-neuronal-stimulus-selectivity
#5
Romain D Cazé, Sarah Jarvis, Amanda J Foust, Simon R Schultz
Hearing, vision, touch: underlying all of these senses is stimulus selectivity, a robust information processing operation in which cortical neurons respond more to some stimuli than to others. Previous models assume that these neurons receive the highest weighted input from an ensemble encoding the preferred stimulus, but dendrites enable other possibilities. Nonlinear dendritic processing can produce stimulus selectivity based on the spatial distribution of synapses, even if the total preferred stimulus weight does not exceed that of nonpreferred stimuli...
June 9, 2017: Neural Computation
https://www.readbyqxmd.com/read/28594466/bleeding-is-not-the-main-clinical-issue-in-many-patients-with-inherited-thrombocytopaenias
#6
REVIEW
F Melazzini, C Zaninetti, C L Balduini
Bleeding diathesis has been considered for a long time the main clinical issue impacting the lives of patients affected by inherited thrombocytopaenias. However, the number of known inherited thrombocytopaenias greatly increased in recent years, and careful evaluation of hundreds of patients affected by these 'new' disorders revealed that most of them are at risk of developing additional life-threatening disorders during childhood or adult life. These additional disorders are usually more serious and dangerous than low platelet count...
June 8, 2017: Haemophilia: the Official Journal of the World Federation of Hemophilia
https://www.readbyqxmd.com/read/28579209/extended-interval-dosing-of-gentamicin-in-premature-neonates-born-at-32-weeks-gestation-and-7-days-of-age
#7
Arun Sundaram, Belal Alshaikh, Deonne Dersch-Mills, Jenna Dobry, Albert R Akierman, Kamran Yusuf
PURPOSE: Extended-interval dosing (EID) regimens of gentamicin have been validated for treating confirmed or suspected early- and late-onset sepsis in preterm infants in the first week of life. Despite the marked changes in volume of distribution and renal clearance in preterm infants after the first few days of life, few studies have validated EID regimens of gentamicin in this population. The objective of the study was to evaluate an EID regimen of gentamicin in infants born at <32 weeks' gestational age and aged >7 days...
May 31, 2017: Clinical Therapeutics
https://www.readbyqxmd.com/read/28576916/fabry-heterozygote-mimicking-multiple-sclerosis
#8
Wai Yan Yau, Marzena J Fabis-Pedrini, Allan G Kermode
Fabry's disease (FD) is a recognised mimic of multiple sclerosis (MS). It is an X-linked storage lysosomal disorder with deficiency of α-galactosidase A and enzyme replacement therapy is available. Patients with FD may satisfy modified McDonald criteria if the diagnosis of FD has not been pursued. We present a case of FD in a 65-year-old woman masquerading as benign MS for 40 years. She has recurrent posterior circulation stroke-like symptoms, hearing loss and acroparaesthesia, but typical radiological features of MS on MRI brain...
June 2, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28576525/an-analysis-of-hearing-screening-test-results-in-2291-premature-infants-of-chinese-population
#9
Lili Huang, Fei Xiong, Jinrong Li, Fan Yang
OBJECTIVE: The aim of this study was to analyze the hearing screening program among preterm infants as well as to identify risk factors associated with failing primary newborn hearing screening. METHODS: The retrospectively selected population included all preterm infants who had primary hearing screening in a neonatal ward from January 1st, 2013 to December 31st, 2015 at West China Second University Hospital, Sichuan University. The newborn hearing screening (NHS) procedure was performed in all preterm infants by automated auditory brainstem response (AABR)...
April 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28566598/late-onset-mitochondrial-cardiomyopathy-triggered-by-anticancer-treatment
#10
Takashi Yamasaki, Kenji Yanishi, Shuhei Tateishi, Naohiko Nakanishi, Kan Zen, Takeshi Nakamura, Tetsuhiro Yamano, Hirokazu Shiraishi, Takeshi Shirayama, Satoaki Matoba
We report the case of a 62-year-old woman with a history of bilateral hearing impairment, who developed mitochondrial cardiomyopathy after chemotherapy. The patient underwent postoperative cisplatin chemotherapy after the surgical treatment of cervical cancer. The systolic function of her left ventricle decreased significantly. A tissue examination of the left ventricle revealed mitochondrial cardiomyopathy. Genetic testing revealed mutations in mitochondrial 3,243 A→G. Nine hundred fifty-five individual mutations were identified by next-generation sequencing...
2017: Internal Medicine
https://www.readbyqxmd.com/read/28555597/hyperbaric-oxygen-therapy-as-salvage-therapy-for-sudden-sensorineural-hearing-loss
#11
Jakov Ajduk, Mihael Ries, Robert Trotic, Ivana Marinac, Kovacic Vlatka, Vladimir Bedekovic
OBJECTIVE: To measure the effect of hyperbaric oxygen (HBO) therapy as salvage therapy after the failure of steroid therapy for sudden sensorineural hearing loss (SSNHL). MATERIALS AND METHODS: Ninety-three patients with SSNHL were unsuccessfully treated with systemic steroid therapy. Following steroid therapy, 43 patients received additional HBO therapy while 50 did not. Hearing levels at 0.25, 0.5, 1, 2, 4, and 8 kHz before and after therapy were measured. RESULTS: A significant difference in hearing thresholds after HBO therapy was found at all frequencies in patients with a hearing loss of >61 dB...
April 2017: Journal of International Advanced Otology
https://www.readbyqxmd.com/read/28538090/late-effects-in-pediatric-high-risk-neuroblastoma-survivors-after-intensive-induction-chemotherapy-followed-by-myeloablative-consolidation-chemotherapy-and-triple-autologous-stem-cell-transplants
#12
Amy E Armstrong, Karina Danner-Koptik, Shannon Golden, Jennifer Schneiderman, Morris Kletzel, Jennifer Reichek, Yasmin Gosiengfiao
Multimodal treatment in high-risk neuroblastoma has modestly improved survival; limited data exist on the late effects from these regimens. We report the sequelae of treatment incorporating 3 consecutive cycles of high-dose therapy and autologous stem cell transplants (ASCTs) without the use of total body irradiation (TBI). We reviewed the medical records of 61 patients treated on or following the Chicago Pilot 2 protocol between 1991 and 2008. Of the 25 patients who are alive (41%), 19 had near complete data to report...
May 23, 2017: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/28533009/comparison-of-implant-stability-measurement-devices-for-bone-anchored-hearing-aid-systems
#13
Lindsey Westover, Gary Faulkner, William Hodgetts, Don Raboud
STATEMENT OF PROBLEM: The success of implants for bone-anchored hearing aids (BAHA) relies on proper osseointegration at the bone-implant interface. Clinical evaluation of implant stability is important in prescribing loading, identifying the risk of failure, and monitoring the long-term health of the implant. PURPOSE: The purpose of this in vitro study was to evaluate 2 measurement systems for BAHA implant stability: the most commonly used, Osstell implant stability quotient (ISQ), and a newly developed advance system for implant stability testing (ASIST)...
May 20, 2017: Journal of Prosthetic Dentistry
https://www.readbyqxmd.com/read/28516364/preserving-normal-facial-nerve-function-and-improving-hearing-outcome-in-large-vestibular-schwannomas-with-a-combined-approach-planned-subtotal-resection-followed-by-gamma-knife-radiosurgery
#14
Roy Thomas Daniel, Constantin Tuleasca, Mercy George, Etienne Pralong, Luis Schiappacasse, Michele Zeverino, Raphael Maire, Marc Levivier
OBJECTIVE: To perform planned subtotal resection followed by gamma knife surgery (GKRS) in a series of patients with large vestibular schwannoma (VS), aiming at an optimal functional outcome for facial and cochlear nerves. METHODS: Patient characteristics, surgical and dosimetric features, and outcome were collected prospectively at the time of treatment and during the follow-up. RESULTS: A consecutive series of 32 patients was treated between July 2010 and June 2016...
July 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28499298/-cochlear-implant-state-of-the-art
#15
Thomas Lenarz
Cochlear implants are the treatment of choice for the auditory rehabilitation of patients with sensory deafness. They restore the missing function of inner hair cells by transforming the acoustic signal into electrical stimuli for activation of auditory nerve fibers. Due to the very fast technology development cochlear implants provide open-set speech understanding in the majority of patients including the use of the telephone. Children can achieve a near to normal speech and language development provided their deafness is detected early after onset and implantation is performed quickly thereafter...
April 2017: Laryngo- Rhino- Otologie
https://www.readbyqxmd.com/read/28499295/-tympanoplasty-news-and-new-perspectives
#16
Marcus Neudert, Thomas Zahnert
Techniques and biomaterials for reconstructive middle ear surgery are under steady, ongoing development. At the same time, clinical post-surgery results are evaluated to determine success or failure of the therapy. Routine quality assessment and assurance is of growing importance in the medical field, and therefore also in middle ear surgery. The exact definition and acquisition of outcome parameters is essential for both a comprehensive and detailed quality assurance. These parameters are not the audiological results alone, but also additional individual parameters which influence the postoperative outcome after tympanoplasty...
April 2017: Laryngo- Rhino- Otologie
https://www.readbyqxmd.com/read/28492927/prevalence-of-auditory-problems-in-children-with-feeding-and-swallowing-disorders
#17
Vishakha Waman Rawool
Purpose: Although an interdisciplinary approach is recommended for assessment and management of feeding or swallowing difficulties, audiologists are not always included in the interdisciplinary team. The purpose of this study is to report the prevalence of middle ear and hearing problems in children with feeding and swallowing disorders and to compare this prevalence with that in typical children. Method: A total of 103 children were included in the study: 44 children with feeding and swallowing disorders and 59 children without any such disorders...
May 24, 2017: Journal of Speech, Language, and Hearing Research: JSLHR
https://www.readbyqxmd.com/read/28491334/increasing-the-rate-of-living-donor-kidney-transplantation-in-ontario-donor-and-recipient-identified-barriers-and-solutions
#18
Leah E Getchell, Susan Q McKenzie, Jessica M Sontrop, Jade S Hayward, Megan K McCallum, Amit X Garg
PURPOSE OF REVIEW: To hear from living kidney donors and recipients about what they perceive are the barriers to living donor kidney transplantation, and how patients can develop and lead innovative solutions to increase the rate and enhance the experiences of living donor kidney transplantation in Ontario. SOURCES OF INFORMATION: A one-day patient-led workshop on March 10th, 2016 in Toronto, Ontario. METHODS: Participants who were previously engaged in priority-setting exercises were invited to the meeting by patient lead, Sue McKenzie...
2017: Canadian Journal of Kidney Health and Disease
https://www.readbyqxmd.com/read/28468898/contribution-of-targeted-saliva-screening-for-congenital-cmv-related-hearing-loss-in-newborns-who-fail-hearing-screening
#19
Daphne Ari-Even Roth, Daniel Lubin, Jacob Kuint, Michal Teperberg-Oikawa, Ella Mendelson, Tzipora Strauss, Galia Barkai
BACKGROUND: We previously reported a 2.2% rate of infants born with sensorineural hearing loss (SNHL) due to congenital cytomegalovirus (cCMV) infection identified by universal neonatal screen for cCMV using saliva. OBJECTIVE: To evaluate the contribution of targeted saliva screening for cCMV to the detection of infants born with cCMV-related SNHL who failed universal newborn hearing screening (UNHS). METHODS: We retrospectively reviewed the audiological and medical records of infants who failed UNHS and were tested for cCMV using saliva sample prior to discharge at Sheba Medical Center between 2014 and 2015...
May 3, 2017: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/28457225/otoacoustic-emissions-in-rural-nicaragua-cost-analysis-and-implications-for-newborn-hearing-screening
#20
Lye-Yeng Wong, Francisca Espinoza, Karen Mojica Alvarez, Dave Molter, James E Saunders
Objective (1) Determine the incidence and risk factors for congenital hearing loss. (2) Perform cost analysis of screening programs. Study Design Proportionally distributed cross-sectional survey. Setting Jinotega, Nicaragua. Subjects and Methods Otoacoustic emissions (OAEs) were used to screen 640 infants <6 months of age from neonatal intensive care unit, institutional, and home birth settings. Data on 15 risk factors were analyzed. Cost of 4 implementation strategies was studied: universal screening, screening at the regional health center (RHC), targeted screening, and screening at the RHC plus targeted screening...
May 2017: Otolaryngology—Head and Neck Surgery
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