keyword
MENU ▼
Read by QxMD icon Read
search

microbiota AND ("intensive care unit" OR ICU)

keyword
https://www.readbyqxmd.com/read/30088841/effect-of-a-probiotic-preparation-on-ventilator-associated-pneumonia-in-critically-ill-patients-admitted-to-the-intensive-care-unit-a-prospective-double-blind-randomized-controlled-trial
#1
Ata Mahmoodpoor, Hadi Hamishehkar, Roghaieh Asghari, Ramin Abri, Kamran Shadvar, Sarvin Sanaie
BACKGROUND: Ventilator-associated pneumonia (VAP) occurs as a life-threatening complication in critically ill mechanically ventilated patients. Probiotic administration may modify the gut microbiota; however, whether this modification could decrease VAP occurrence is not known. METHODS: In this study, 100 adult critically ill patients undergoing mechanical ventilation for >48 hours were randomly assigned to either the probiotic or the control group. The patients in the probiotic group received 2 capsules of probiotic preparation containing Lactobacillus, Bifidobacterium, and Streptococcus spp...
August 8, 2018: Nutrition in Clinical Practice
https://www.readbyqxmd.com/read/30050661/urinary-1-h-nmr-metabolomics-in-the-first-week-of-life-can-anticipate-bpd-diagnosis
#2
Maria Cristina Pintus, Milena Lussu, Angelica Dessì, Roberta Pintus, Antonio Noto, Valentina Masile, Maria Antonietta Marcialis, Melania Puddu, Vassilios Fanos, Luigi Atzori
Despite the advancements in medical knowledge and technology, the etiopathogenesis of bronchopulmonary dysplasia (BPD) is not yet fully understood although oxidative stress seems to play a role, leading to a very demanding management of these patients by the neonatologist. In this context, metabolomics can be useful in understanding, diagnosing, and treating this illness since it is one of the newest omics science that analyzes the metabolome of an individual through the investigation of biological fluids such as urine and blood...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/30049266/lower-respiratory-tract-microbial-composition-was-diversified-in-pseudomonas-aeruginosa-ventilator-associated-pneumonia-patients
#3
Xiaoling Qi, Hongping Qu, Dandan Yang, Lian Zhou, Ya-Wen He, Yuetian Yu, Jieming Qu, Jialin Liu
BACKGROUND: Probiotics could prevent Pseudomonas aeruginosa colonization in lower respiratory tract (LRT) and reduced P. aeruginosa ventilator-associated pneumonia (VAP) rate. Recent studies also suggested that probiotics could improve lung inflammation in mice infected with P. aeruginosa. It seems that microbiota regulation may be a potential therapy for P. aeruginosa VAP patients. However, we know less about the LRT microbial composition and its correlation with prognosis in P. aeruginosa VAP patients...
July 27, 2018: Respiratory Research
https://www.readbyqxmd.com/read/30010618/antibiotic-therapy-induced-collateral-damage-iga-takes-center-stage-in-pulmonary-host-defense
#4
Juergen Lohmeyer, Rory E Morty, Susanne Herold
The use of broad-spectrum antibiotics in empirical antimicrobial therapy is a lifesaving strategy for patients in intensive care. At the same time, antibiotics dramatically increase the risk for nosocomial infections, such as hospital‑acquired pneumonia caused by Pseudomonas aeruginosa, and other antibiotic-resistant bacteria. In this issue of the JCI, Robak and colleagues identified a mechanism by which depletion of resident gut and lung microbiota by antibiotic treatment results in secondary IgA deficiency and impaired anti-P...
August 1, 2018: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29997594/preterm-gut-microbiome-depending-on-feeding-type-significance-of-donor-human-milk
#5
Anna Parra-Llorca, María Gormaz, Cristina Alcántara, María Cernada, Antonio Nuñez-Ramiro, Máximo Vento, Maria C Collado
Preterm microbial colonization is affected by gestational age, antibiotic treatment, type of birth, but also by type of feeding. Breast milk has been acknowledged as the gold standard for human nutrition. In preterm infants breast milk has been associated with improved growth and cognitive development and a reduced risk of necrotizing enterocolitis and late onset sepsis. In the absence of their mother's own milk (MOM), pasteurized donor human milk (DHM) could be the best available alternative due to its similarity to the former...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29996183/-impact-on-the-intestinal-microbiota-of-early-antibiotic-treatment-in-preterm-neonates
#6
W W Zhu, Z L Li
Objective: To investigate the impact of early antibiotics treatment on intestinal microbiota in preterm infants. Methods: The cohort study was performed from January 2015 to June 2015 in Neonatal Intensive Care Unit of Peking University Third Hospital. A total of 33 preterm infants were enrolled, among whom 25 were antibiotics-exposure group, and 8 were non-exposure group. Serial stool samples were collected on the first day, 14th and 30th days of life and analyzed by high-throughput sequencing. In exposure group, intestinal microbiota was also analyzed at 8 months to 1 year of age...
July 2, 2018: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/29988506/comparison-of-infant-gut-and-skin-microbiota-resistome-and-virulome-between-neonatal-intensive-care-unit-nicu-environments
#7
Suchitra K Hourigan, Poorani Subramanian, Nur A Hasan, Allison Ta, Elisabeth Klein, Nassim Chettout, Kathi Huddleston, Varsha Deopujari, Shira Levy, Rajiv Baveja, Nicole C Clemency, Robin L Baker, John E Niederhuber, Rita R Colwell
Background: There is a growing move to provide care for premature infants in a single family, private room neonatal intensive care unit (NICU) in place of the traditional shared space, open bay NICU. The resultant effect on the developing neonatal microbiota is unknown. Study Design: Stool and groin skin swabs were collected from infants in a shared-space NICU (old NICU) and a single-family room NICU (new NICU) on the same hospital campus. Metagenomic sequencing was performed and data analyzed by CosmosID bioinformatics software package...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29963643/molecular-analysis-of-endotracheal-tube-biofilms-and-tracheal-aspirates-in-the-pediatric-intensive-care-unit
#8
Matthew K Leroue, J Kirk Harris, Katherine M Burgess, Mark J Stevens, Joshua I Miller, Marci K Sontag, Yamila L Sierra, Brandie D Wagner, Peter M Mourani
Background: Ventilator-associated pneumonia (VAP) is a known complication of mechanically ventilated children in the pediatric intensive care unit (PICU). Endotracheal tube (ETT) biofilms are often implicated in the development of VAP by providing a conduit for pathogens to the lower respiratory tract. Methods: A prospective cohort study from April 2010-March 2011 of children 4 weeks to 18 years of age ventilated for greater than 72 hours to determine the microbiota of ETT biofilms and tracheal aspirates...
December 2017: Advances in Pediatric Research
https://www.readbyqxmd.com/read/29931245/late-onset-sepsis-in-preterm-infants-can-be-detected-preclinically-by-fecal-volatile-organic-compound-analysis-a-prospective-multicenter-cohort-study
#9
Daniel J C Berkhout, Britt J van Keulen, Hendrik J Niemarkt, Jet R Bessem, Willem P de Boode, Veerle Cossey, Neil Hoogenes, Christiaan V Hulzebos, Ellen Klaver, Peter Andriessen, Anton H van Kaam, Boris W Kramer, Richard A van Lingen, Aaron Schouten, Johannes B van Goudoever, Daniel C Vijlbrief, Mirjam M van Weissenbruch, Alfian N Wicaksono, James A Covington, Marc A Benninga, Nanne K H de Boer, Tim G J de Meij
Background: The intestinal microbiota has increasingly been considered to play a role in the etiology of late-onset sepsis (LOS). We hypothesize that early alterations in fecal volatile organic compounds (VOCs), reflecting intestinal microbiota composition and function, allow for discrimination between infants developing LOS and controls in a preclinical stage. Methods: In 9 neonatal intensive care units in the Netherlands and Belgium, fecal samples of preterm infants born at a gestational age ≤30 weeks were collected daily, up to the postnatal age of 28 days...
June 21, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29909714/preterm-infant-gut-microbial-patterns-related-to-the-development-of-necrotizing-enterocolitis
#10
Tristan P Lindberg, Melissa J Caimano, James I Hagadorn, Erin M Bennett, Kendra Maas, Elizabeth A Brownell, Adam P Matson
OBJECTIVES: To define gut microbial patterns in preterm infants with and without necrotizing enterocolitis (NEC) and to characterize clinical factors related to the composition of the preterm intestinal microbiome. METHODS: Fecal samples were collected at one-week intervals from infants with gestational ages <30 weeks at a single level IV neonatal intensive care unit. Using 16S rRNA gene sequencing, the composition and diversity of microbiota were determined in samples collected from five NEC infants and five matched controls...
July 18, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29898981/rectal-and-naris-swabs-practical-and-informative-samples-for-analyzing-the-microbiota-of-critically-ill-patients
#11
Saumya Bansal, Jenny P Nguyen, Aleksandra Leligdowicz, Yu Zhang, Kevin C Kain, Daniel R Ricciuto, Bryan Coburn
Commensal microbiota are immunomodulatory, and their pathological perturbation can affect the risk and outcomes of infectious and inflammatory diseases. Consequently, the human microbiota is an emerging diagnostic and therapeutic target in critical illness. In this study, we compared four sample types-rectal, naris, and antecubital swabs and stool samples-for 16S rRNA gene microbiota sequencing in intensive care unit (ICU) patients. Stool samples were obtained in only 31% of daily attempts, while swabs were reliably obtained (≥97% of attempts)...
June 13, 2018: MSphere
https://www.readbyqxmd.com/read/29890556/-management-of-clostridium-difficile-infections-at-german-intensive-care-units-results-from-a-survey-among-intensivists
#12
Jan Bruensing, Lukas Buendgens, Christoph Jochum, Ulf Herbers, Ali Canbay, Georg Braun, Christian Trautwein, Wolfgang Huber, Alexander Koch, Frank Tacke
BACKGROUND: Clostridium difficile associated colitis is a frequent cause of nosocomial diarrhea at the intensive care unit (ICU) and is associated with poor prognosis in critically ill patients. Few studies have evaluated the efficacy of treatment options or adherence to guideline recommendations of Clostridium difficile infections at the ICU. METHODS: Therefore, on behalf of the Gastroenterology Intensive Care Medicine working group of the DGVS, we have conducted an online-based survey among leading intensivists in Germany...
June 2018: Zeitschrift Für Gastroenterologie
https://www.readbyqxmd.com/read/29875143/the-microbiome-and-metabolome-of-preterm-infant-stool-are-personalized-and-not-driven-by-health-outcomes-including-necrotizing-enterocolitis-and-late-onset-sepsis
#13
Stephen Wandro, Stephanie Osborne, Claudia Enriquez, Christine Bixby, Antonio Arrieta, Katrine Whiteson
The assembly and development of the gut microbiome in infants have important consequences for immediate and long-term health. Preterm infants represent an abnormal case for bacterial colonization because of early exposure to bacteria and frequent use of antibiotics. To better understand the assembly of the gut microbiota in preterm infants, fecal samples were collected from 32 very low birth weight preterm infants over the first 6 weeks of life. Infant health outcomes included health, late-onset sepsis, and necrotizing enterocolitis (NEC)...
June 27, 2018: MSphere
https://www.readbyqxmd.com/read/29870851/what-s-new-in-restoring-the-gut-microbiota-in-icu-patients-potential-role-of-faecal-microbiota-transplantation
#14
EDITORIAL
E Ruppé, I Martin-Loeches, A Rouzé, B Levast, T Ferry, J-F Timsit
No abstract text is available yet for this article.
August 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29795209/the-premature-infant-gut-microbiome-during-the-first-6-weeks-of-life-differs-based-on-gestational-maturity-at-birth
#15
Diana A Chernikova, Juliette C Madan, Molly L Housman, Muhammad Zain-Ul-Abideen, Sara N Lundgren, Hilary G Morrison, Mitchell L Sogin, Scott M Williams, Jason H Moore, Margaret R Karagas, Anne G Hoen
BACKGROUND: The impact of degree of prematurity at birth on premature infant gut microbiota has not been extensively studied in comparison to term infants in large cohorts. METHODS: To determine the effect of gestational age at birth and postnatal exposures on gut bacterial colonization in infants, we analyzed 65 stool samples from 17 premature infants in the neonatal intensive care unit, as well as 13 samples from 13 mostly moderate-to-late premature infants and 189 samples from 176 term infants in the New Hampshire Birth Cohort Study...
May 23, 2018: Pediatric Research
https://www.readbyqxmd.com/read/29771684/antibiotic-treatment-induced-secondary-iga-deficiency-enhances-susceptibility-to-pseudomonas-aeruginosa-pneumonia
#16
Oliver H Robak, Markus M Heimesaat, Andrey A Kruglov, Sandra Prepens, Justus Ninnemann, Birgitt Gutbier, Katrin Reppe, Hubertus Hochrein, Mark Suter, Carsten J Kirschning, Veena Marathe, Jan Buer, Mathias W Hornef, Markus Schnare, Pascal Schneider, Martin Witzenrath, Stefan Bereswill, Ulrich Steinhoff, Norbert Suttorp, Leif E Sander, Catherine Chaput, Bastian Opitz
Broad-spectrum antibiotics are widely used with patients in intensive care units (ICUs), many of whom develop hospital-acquired infections with Pseudomonas aeruginosa. Although preceding antimicrobial therapy is known as a major risk factor for P. aeruginosa-induced pneumonia, the underlying mechanisms remain incompletely understood. Here we demonstrate that depletion of the resident microbiota by broad-spectrum antibiotic treatment inhibited TLR-dependent production of a proliferation-inducing ligand (APRIL), resulting in a secondary IgA deficiency in the lung in mice and human ICU patients...
August 1, 2018: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29707661/vim-klebsiella-oxytoca-outbreak-in-a-neonatal-intensive-care-unit-this-time-it-wasn-t-the-drain
#17
R Herruzo, G Ruiz, S Gallego, J Diez, A Sarria, F Omeñaca
Objective: We describe an outbreak of VIM-carbapenemase Klebsiella oxytoca (VIM-Kox) in a NICU. Materials and methods: Prospective Epidemiological Surveillance:Systematically (weekly screening cultures) or on admission, if the patient had a history of previous colonization by VIM-Kox.Clinical cultures, done if infection was suspected.Other possible microorganism sources were investigated: their mothers (rectal microbiota), milk packages and preparation apparata in the lactodietary section, echocardiagram transductors, cribs, the sinks (faucets and drains), washing bowls, etc...
December 2017: Journal of Preventive Medicine and Hygiene
https://www.readbyqxmd.com/read/29689120/acute-on-chronic-liver-failure-getting-ready-for-prime-time
#18
Jasmohan S Bajaj, Richard Moreau, Patrick S Kamath, Hugo E Vargas, Vicente Arroyo, K Rajender Reddy, Gyongyi Szabo, Puneeta Tandon, Jody Olson, Constantine Karvellas, Thierry Gustot, Jennifer C Lai, Florence Wong
Acute on chronic liver failure (ACLF) is a culmination of chronic liver disease and extra-hepatic organ failures, which is associated with a high short-term mortality and immense healthcare expenditure. There are varying definitions for organ failures and ACLF in Europe, North America and Asia. These differing definitions need to be reconciled to enhance progress in the field. The pathogenesis of ACLF is multi-factorial and related to interactions between the immuno-inflammatory system, microbiota and the precipitating factors...
April 24, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29688458/preterm-infants-have-distinct-microbiomes-not-explained-by-mode-of-delivery-breastfeeding-duration-or-antibiotic-exposure
#19
Cecilie Dahl, Hein Stigum, Jørgen Valeur, Nina Iszatt, Virissa Lenters, Shyamal Peddada, Jørgen V Bjørnholt, Tore Midtvedt, Siddhartha Mandal, Merete Eggesbø
Background: Preterm infants have low gut microbial diversity and few anaerobes. It is unclear whether the low diversity pertains to prematurity itself or is due to differences in delivery mode, feeding mode or exposure to antibiotics. Methods: The Norwegian Microbiota Study (NoMIC) was established to examine the colonization of the infant gut and health outcomes. 16S rRNA gene Illumina amplicon-sequenced samples from 519 children (160 preterms), collected at 10 days, 4 months and 1 year postnatally, were used to calculate alpha diversity...
April 20, 2018: International Journal of Epidemiology
https://www.readbyqxmd.com/read/29670613/innate-immunity-in-the-persistent-inflammation-immunosuppression-and-catabolism-syndrome-and-its-implications-for-therapy
#20
REVIEW
Hiroyuki Horiguchi, Tyler J Loftus, Russell B Hawkins, Steven L Raymond, Julie A Stortz, McKenzie K Hollen, Brett P Weiss, Elizabeth S Miller, Azra Bihorac, Shawn D Larson, Alicia M Mohr, Scott C Brakenridge, Hironori Tsujimoto, Hideki Ueno, Frederick A Moore, Lyle L Moldawer, Philip A Efron
Clinical and technological advances promoting early hemorrhage control and physiologic resuscitation as well as early diagnosis and optimal treatment of sepsis have significantly decreased in-hospital mortality for many critically ill patient populations. However, a substantial proportion of severe trauma and sepsis survivors will develop protracted organ dysfunction termed chronic critical illness (CCI), defined as ≥14 days requiring intensive care unit (ICU) resources with ongoing organ dysfunction...
2018: Frontiers in Immunology
keyword
keyword
165665
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"