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butyrate AND barrier

Canxia He, Lei Huang, Peng Lei, Xiaodong Liu, Baolong Li, Yujuan Shan
SCOPE: Gut microbiota imbalance, inflammation and gut barrier deficiency play an important role in carcinogenesis. Sulforaphane (SFN), an isothiocyanate found in cruciferous vegetables, has been proven to be highly effective in inhibiting cancer. The objective of this study is to investigate the potential roles of the gut microbiota in the inhibition of BBN-induced bladder cancer by SFN. METHODS AND RESULTS: N-butyl-N-(4-hydroxybutyl) -nitrosamine was used to induce bladder cancer in male C57BL/6 mice, with or without SFN for 23 weeks...
October 10, 2018: Molecular Nutrition & Food Research
Yafei Duan, Yun Wang, Hongbiao Dong, Xian Ding, Qingsong Liu, Hua Li, Jiasong Zhang, Dalin Xiong
The intestine barrier serves as the front-line defense in shrimp. Clostridium butyricum (CB) can produce butyric acid that provides energy for the intestine epithelial cells of the host. However, the effects of dietary CB on the intestine microbiome and the digestion and immunity of the host is not clear. In this study, we therefore investigated the composition and metabolic activity of the intestine microbiome, and digestive and immune-related gene expression in Litopenaeus vannamei fed with diets containing different levels of CB: basal diet (control), 2...
2018: Frontiers in Microbiology
Fan Hu, Yanfeng Xue, Changzheng Guo, Junhua Liu, Shengyong Mao
The objective of this study was to evaluate the changes in the ruminal fermentation, epithelium-associated microbiota, and ruminal epithelial barrier function in response to severe feed restriction (SFR) in pregnant ewes. Sixteen pregnant ewes (108 d of gestation) were randomly blocked and assigned to 1 of 2 treatments: control (CON, n = 8) and SFR (n = 8). Ewes were fed a common diet with a 60:40 forage to concentrate ratio for 7-d baseline period followed by a SFR challenge period. Ewes on the SFR treatment were restricted to 30% of the base for 15 d...
September 29, 2018: Journal of Animal Science
X Jia, L Jia, L Mo, S Yuan, X Zheng, J He, V Chen, Q Guo, L Zheng, Q Yuan, X Xu, X Zhou
Postmenopausal osteoporosis (PMO) is a risk factor for periodontitis, and current therapeutics against PMO prevent the aggravated alveolar bone loss of periodontitis in estrogen-deficient women. Gut microbiota is recognized as a promising therapeutic target for PMO. Berberine extracted from Chinese medicinal plants has shown its effectiveness in the treatment of metabolic diseases such as obesity and diabetes via regulating gut microbiota. Here, we hypothesize that berberine ameliorates periodontal bone loss by improving the intestinal barriers by regulating gut microbiota under an estrogen-deficient condition...
September 10, 2018: Journal of Dental Research
Jing Wang, Haifeng Ji, Sixin Wang, Hui Liu, Wei Zhang, Dongyan Zhang, Yamin Wang
Weaning disturbs the intestinal barrier function and increases the risk of infection in piglets. Probiotics exert beneficial health effects, mainly by reinforcing the intestinal epithelium and modulating the gut microbiota. However, the mechanisms of action, and especially, the specific regulatory effects of modulated microbiota by probiotics on the intestinal epithelium have not yet been elucidated. The present study aimed to decipher the protective effects of the probiotic Lactobacillus plantarum strain ZLP001 on the intestinal epithelium and microbiota as well as the effects of modulated microbiota on epithelial function...
2018: Frontiers in Microbiology
Jianzhong Ye, Longxian Lv, Wenrui Wu, Yating Li, Ding Shi, Daiqiong Fang, Feifei Guo, Huiyong Jiang, Ren Yan, Wanchun Ye, Lanjuan Li
Butyrate exerts protective effects against non-alcoholic steatohepatitis (NASH), but the underlying mechanisms are unclear. We aimed to investigate the role of butyrate-induced gut microbiota and metabolism in NASH development. Sixty-five C57BL/6J mice were divided into four groups ( n = 15-17 per group) and were fed either a methionine-choline-sufficient (MCS) diet or methionine-choline-deficient (MCD) diet with or without sodium butyrate (SoB; 0.6 g/kg body weight) supplementation for 6 weeks. Liver injury, systematic inflammation, and gut barrier function were determined...
2018: Frontiers in Microbiology
Yanhai Feng, Yu Wang, Pei Wang, Yalan Huang, Fengjun Wang
BACKGROUND/AIMS: Short-chain fatty acids (SCFAs) are the major energy resources of intestinal epithelial cells. It has been reported that SCFAs can repair the dysfunction of intestinal barrier, however, the underlying mechanisms are still not fully understood. Here, we investigated the stimulative and protective effects of SCFAs on intestinal barrier function and the possible mechanisms. METHODS: To investigate the effects of SCFAs on intestinal barrier function, the Caco-2 monolayers were exposed to acetate, propionate, butyrate respectively or simultaneously without or with lipopolysaccharide (LPS)...
2018: Cellular Physiology and Biochemistry
Lei Wu, Yuli Bai, Min Liu, Lian Li, Wei Shan, Zhirong Zhang, Yuan Huang
The intestinal epithelium constitutes a major barrier for orally delivered nanoparticles (NPs). Although surface ligand modification can increase cellular uptake of NPs, the transepithelial transport of active targeting NPs is relatively limited. The phenomenon is described as "easy entry, hard transcytosis". However, underlying mechanisms and potential solutions of this phenomenon are unclear. Here, butyrate modified polyethylene glycol coated NPs (Bu-PEG NPs) were chosen as the model active targeting NPs...
September 4, 2018: Molecular Pharmaceutics
Austin Gonzalez, Richard Krieg, Hugh D Massey, Daniel Carl, Shobha Ghosh, Todd W B Gehr, Siddhartha S Ghosh
Background: The associated increase in the lipopolysaccharide (LPS) levels and uremic toxins in chronic kidney disease (CKD) has shifted the way we focus on intestinal microbiota. This study shows that a disruption of the intestinal barrier in CKD promotes leakage of LPS from the gut, subsequently decreasing insulin sensitivity. Butyrate treatment improved the intestinal barrier function by increasing colonic mucin and tight junction (TJ) proteins. This modulation further ameliorated metabolic functions such as insulin intolerance and improved renal function...
August 6, 2018: Nephrology, Dialysis, Transplantation
Sadia Kanwal, Thomson Patrick Joseph, Lawrence Owusu, Ren Xiaomeng, Li Meiqi, Xin Yi
Despite the tremendous biological activity of polysaccharides from the mushroom Dictyophora indusiata , its role in the restoration of gut microbiota has not yet been explored. The present study aimed to investigate whether D. indusiata polysaccharide (DIP) could modulate the recovery of gut microbiota composition and intestinal barrier function after broad-spectrum antibiotic-driven dysbiosis. Alteration and restoration in the microbial communities were elucidated by the Illumina MiSeq platform. Colon histology, expression of tight-junction associated proteins, and serum/tissue endotoxin and cytokine levels were evaluated...
July 31, 2018: Nutrients
Xiaozhou Yu, Haoming Yan, Qing Peng
Atomic layer deposition (ALD) of oxide film on [6,6]-phenyl-C61 butyric acid methyl ester (PCBM) shows a great promise to dramatically improve the ambient stability of hybrid halide perovskite. The nucleation of an ALD oxide on PCBM is critical to reliably apply this strategy. In this paper, we present the first study of the nucleation behavior of ALD oxides, including Al2 O3 and ZnO, on PCBM. We find that PCBM film acts a gas diffusion barrier blocking the ALD reactants (diethyl zinc) from etching the underlying CH3 NH3 PbI3 ...
August 29, 2018: ACS Applied Materials & Interfaces
Kai Zhang, Meijuan Meng, Lipeng Gao, Yuanlu Tu, Yunfeng Bai
We investigated the effect of sodium butyrate feeding on the disruption of ruminal epithelium barrier function in goats fed a high-concentrate diet. A total of 18 male Boer goats (live weight of 31.75 ± 1.35 kg, aged 1 year) were randomly assigned to three groups, which were fed a low-concentrate diet (LC), a high-concentrate diet (HC), or a high-concentrate diet with 1% sodium butyrate by weight (SH) for 9 weeks. We found that the pH of rumen fluid in the SH and LC groups was higher than that in the HC group...
August 22, 2018: Journal of Agricultural and Food Chemistry
Sohail Abdul Salim, Litty Thomas, Anand Achanti, Monika Beck Gööz, Jorge Castaneda, István Arany, Albert W Dreisbach, Tibor Fülöp
Baclofen is a centrally-acting γ-amino butyric acid agonist used mainly in the symptomatic management of spasticity originating from the spinal cord. It is absorbed completely from the gastrointestinal tract, metabolized by the liver to a minor degree, and excreted unchanged by the kidneys. Baclofen is moderately lipophilic and can cross the blood-brain barrier easily. At the usual dosage, it acts mainly at the spinal level without central nervous system (CNS) side effects. During renal failure, however, the elimination of the drug will decrease with a prolonged half-life, resulting in a larger area-under-the-curve exposure and disproportionate CNS toxicity...
October 2018: International Journal of Clinical Pharmacology and Therapeutics
He Jiang, Gelei Jiang, Weiwei Xing, Weiming Xiong, Xiaoyue Zhang, Biao Wang, Huiyan Zhang, Yue Zheng
We propose a doping method by using [6,6]-phenyl-C61 -butyric acid methyl ester (PCBM) to fill the grain boundary interstices of the methylammonium lead iodide (CH3 NH3 PbI3 ) perovskite for the elimination of pinholes. A sandwiched PCBM layer is also used between the perovskite and TiO2 layers to improve the interfacial contact. By using these two methods, the fabricated perovskite solar cells show a low hysteresis effect and high current density, which result from the improved compactness at the grain boundaries of the perovskite surface and the interface between the TiO2 /perovskite layers...
September 5, 2018: ACS Applied Materials & Interfaces
Wenqian Feng, Yancheng Wu, Guangxin Chen, Shoupeng Fu, Bai Li, Bingxu Huang, Dali Wang, Wei Wang, Juxiong Liu
BACKGROUND/AIMS: Butyric acid plays an important role in maintaining intestinal health. Butyric acid has received special attention as a short-chain fatty acid, but its role in protecting the intestinal barrier is poorly characterized. Butyric acid not only provides energy for epithelial cells but also acts as a histone deacetylase inhibitor; it is also a natural ligand for G protein-coupled receptor 109A (GPR109A). A GPR109A analog was expressed in Sus scrofa and mediated the anti-inflammatory effects of beta-hydroxybutyric acid...
2018: Cellular Physiology and Biochemistry
You-Hua Xu, Chen-Lin Gao, Heng-Li Guo, Wen-Qian Zhang, Wei Huang, Shan-Shan Tang, Wen-Jun Gan, Yong Xu, Hua Zhou, Quan Zhu
Endotoxemia has been recognized to be closely accompanied with type 2 diabetes mellitus (T2DM) and is responsible for many diabetic complications. Recent study suggests the potential role of butyrate, a short-chain fatty acid (SCFA) from microbiota metabolite, on T2DM. Gut-leak is a key event in diabetic-endotoxemia. To investigate if butyrate could ameliorate diabetic-endotoxemia, both in vivo and in vitro experiments were carried out in the present study. The effect of butyrate supplementation on blood HbA1c and inflammatory cytokines were determined in db/db mice; gut barrier integrity and expression of tight junction proteins were investigated both in vivo and in vitro Oral butyrate administration significantly decreased blood HbA1c, inflammatory cytokines and LPS in db/db mice; inflammatory cell infiltration was reduced, and gut integrity and intercellular adhesion molecules were increased as detected by HE staining, immunohistochemistry and Western blot...
September 2018: Journal of Endocrinology
Michelle L Wright, Christina Fournier, Madelyn C Houser, Malú Tansey, Jonathan Glass, Vicki Stover Hertzberg
Amyotrophic lateral sclerosis (ALS) etiology and pathophysiology are not well understood. Recent data suggest that dysbiosis of gut microbiota may contribute to ALS etiology and progression. This review aims to explore evidence of associations between gut microbiota and ALS etiology and pathophysiology. Databases were searched for publications relevant to the gut microbiome in ALS. Three publications provided primary evidence of changes in microbiome profiles in ALS. An ALS mouse model revealed damaged tight junction structure and increased permeability in the intestine versus controls along with a shifted microbiome profile, including decreased levels of butyrate-producing bacteria...
October 2018: Biological Research for Nursing
João C P Silva, Marta Mota, Fátima O Martins, Célia Nogueira, Teresa Gonçalves, Tatiana Carneiro, Joana Pinto, Daniela Duarte, António S Barros, John G Jones, Ana M Gil
Increased sugar intake is implicated in Type-2 diabetes and fatty liver disease; however, the mechanisms through which glucose and fructose promote these conditions are unclear. We hypothesize that alterations in intestinal metabolite and microbiota profiles specific to each monosaccharide are involved. Two groups of six adult C57BL/6 mice were fed for 10-weeks with diets with glucose (G) or fructose (F) as sole carbohydrates, and a third group was fed with a normal chow carbohydrate mixture (N). Fecal metabolites were profiled by nuclear magnetic resonance (NMR) and microbial composition by real-time polymerase chain reaction (qPCR)...
August 3, 2018: Journal of Proteome Research
D Maciejewska, K Skonieczna-Zydecka, A Lukomska, I Gutowska, K Dec, P Kupnicka, J Palma, A Pilutin, W Marlicz, E Stachowska
Short chain fatty acids (SCFA) are produced by the gut microbiota during the fermentation of non-digestible polysaccharides. Diet is a major factor driving the composition and metabolism of the colonic microbiota. The aim of our study was to examine how a fat-rich and cholesterol-rich diet that, which leads to many metabolic disorders, affects the SCFA profile and lipopolysaccharide (LPS) concentration. The experiment was carried out on 72 male, 8-weeks-old Sprague-Dawley rats. The study group (n = 30 rats) received high-fat and high cholesterol diet (HFHCh)...
April 2018: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
Prasant Kumar Jena, Lili Sheng, Nidhi Nagar, Chao Wu, Daniela Barile, David A Mills, Yui-Jui Yvonne Wan
Probiotic Bifidobacterium longum subspecies infantis ( Bifidobacterium infantis ) consumes human milk oligosaccharides (MO) and protects intestinal permeability thereby having anti-inflammatory effects (Underwood et al., 2015; Bode, 2006; Asakuma et al., 2011) [1-3]. Via the gut-liver axis, gut barrier disruption and dysbiosis lead to hepatic inflammation (Sheng et al., 2017; Jena et al., 2017) [4,5,6]. Our published data revealed that butyrate, as well as synbiotics of B. infantis in combination with MO, had protective effects against cancer-prone non-alcoholic steatohepatitis (NASH) mouse models, i...
August 2018: Data in Brief
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