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butyrate AND barrier

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https://www.readbyqxmd.com/read/30102863/transport-mechanisms-of-butyrate-modified-nanoparticles-insight-into-easy-entry-hard-transcytosis-of-active-targeting-system-in-oral-administration
#1
Lei Wu, Yuli Bai, Min Liu, Lian Li, Wei Shan, Zhirong Zhang, Yuan Huang
The intestinal epithelium constitutes a major barrier for orally delivered nanoparticles (NPs). Although surface ligand modification can increase cellular uptake of NPs, the transepithelial transport of active targeting NPs is relatively limited. The phenomenon is described as "easy entry, hard transcytosis". Yet, underlying mechanisms and potential solutions of this phenomenon are unclear. Here, butyrate modified polyethylene glycol coated NPs (Bu-PEG NPs) were chosen as the model active targeting NPs...
August 13, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/30085297/sodium-butyrate-ameliorates-insulin-resistance-and-renal-failure-in-ckd-rats-by-modulating-intestinal-permeability-and-mucin-expression
#2
Austin Gonzalez, Richard Krieg, Hugh D Massey, Daniel Carl, Shobha Ghosh, Todd W B Gehr, Siddhartha S Ghosh
Background: The associated increase in the lipopolysaccharide (LPS) levels and uremic toxins in chronic kidney disease (CKD) has shifted the way we focus on intestinal microbiota. This study shows that a disruption of the intestinal barrier in CKD promotes leakage of LPS from the gut, subsequently decreasing insulin sensitivity. Butyrate treatment improved the intestinal barrier function by increasing colonic mucin and tight junction (TJ) proteins. This modulation further ameliorated metabolic functions such as insulin intolerance and improved renal function...
August 6, 2018: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/30065236/a-polysaccharide-isolated-from-dictyophora-indusiata-promotes-recovery-from-antibiotic-driven-intestinal-dysbiosis-and-improves-gut-epithelial-barrier-function-in-a-mouse-model
#3
Sadia Kanwal, Thomson Patrick Joseph, Lawrence Owusu, Ren Xiaomeng, Li Meiqi, Xin Yi
Despite the tremendous biological activity of polysaccharides from the mushroom Dictyophora indusiata , its role in the restoration of gut microbiota has not yet been explored. The present study aimed to investigate whether D. indusiata polysaccharide (DIP) could modulate the recovery of gut microbiota composition and intestinal barrier function after broad-spectrum antibiotic-driven dysbiosis. Alteration and restoration in the microbial communities were elucidated by the Illumina MiSeq platform. Colon histology, expression of tight-junction associated proteins, and serum/tissue endotoxin and cytokine levels were evaluated...
July 31, 2018: Nutrients
https://www.readbyqxmd.com/read/30058323/improve-the-stability-of-hybrid-halide-perovskite-via-atomic-layer-deposition-on-activated-phenyl-c-61-butyric-acid-methyl-ester
#4
Xiaozhou Yu, Haoming Yan, Qing Peng
Atomic layer deposition (ALD) of oxide film on [6,6]-phenyl-C61 butyric acid methyl ester (PCBM) shows a great promise to dramatically improve the ambient stability of hybrid halide perovskite. The nucleation of an ALD oxide on PCBM is critical to reliably apply this strategy. In this paper, we present the first study of the nucleation behavior of ALD oxides, including Al2 O3 and ZnO, on PCBM. We find that PCBM film acts a gas diffusion barrier blocking the ALD reactants (diethyl zinc) from etching the underlying CH3 NH3 PbI3 ...
August 15, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/30008219/sodium-butyrate-improves-high-concentrate-diet-induced-impairment-of-ruminal-epithelium-barrier-function-in-goats
#5
Kai Zhang, Meijuan Meng, Lipeng Gao, Yuanyu Tu, Yunfeng Bai
We investigated the effect of sodium butyrate feeding on the disruption of ruminal epithelium barrier function in goats fed a high-concentrate diet. Eighteen male Boer goats (live weight 31.75 ± 1.35 kg, aged 1 year) were randomly assigned to one of three groups, which were fed a low-concentrate diet (LC), a high-concentrate diet (HC), or a high-concentrate diet with 1% sodium butyrate by weight (SH) for 9 weeks. We found that the pH of rumen fluid in the SH and LC groups was higher than that in the HC group...
July 16, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29974857/review-of-baclofen-induced-neurotoxicity-in-patients-with-compromised-renal-function
#6
Sohail Abdul Salim, Litty Thomas, Anand Achanti, Monika Beck Gööz, Jorge Castaneda, István Arany, Albert W Dreisbach, Tibor Fülöp
Baclofen is a centrally-acting γ-amino butyric acid agonist used mainly in the symptomatic management of spasticity originating from the spinal cord. It is absorbed completely from the gastrointestinal tract, metabolized by the liver to a minor degree, and excreted unchanged by the kidneys. Baclofen is moderately lipophilic and can cross the blood-brain barrier easily. At the usual dosage, it acts mainly at the spinal level without central nervous system (CNS) side effects. During renal failure, however, the elimination of the drug will decrease with a prolonged half-life, resulting in a larger area-under-the-curve exposure and disproportionate CNS toxicity...
July 5, 2018: International Journal of Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29969005/high-current-density-and-low-hysteresis-effect-of-planar-perovskite-solar-cell-via-pcbm-doping-and-interfacial-improvement
#7
He Jiang, Gelei Jiang, Weiwei Xing, Weiming Xiong, Xiaoyue Zhang, Biao Wang, Huiyan Zhang, Yue Zheng
We propose a doped method by using [6,6]-phenyl-C61-butyric acid methyl ester (PCBM) as dopant to stuff the pure iodine base perovskite (CH3NH3PbI3) surface grain boundary. PCBM is established on TiO2 as an additional layer to improve the interface contact. These methods demonstrate its superior in very low hysteresis effect (LHE) as well as high current density (HCD) in perovskite solar cell because of the improvement of interface contact at TiO2/perovskite and impressive compactness with pinhole-free and few grain boundaries perovskite surface...
July 3, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29949795/sodium-butyrate-attenuates-diarrhea-in-weaned-piglets-and-promotes-tight-junction-protein-expression-in-colon-in-a-gpr109a-dependent-manner
#8
Wenqian Feng, Yancheng Wu, Guangxin Chen, Shoupeng Fu, Bai Li, Bingxu Huang, Dali Wang, Wei Wang, Juxiong Liu
BACKGROUND/AIMS: Butyric acid plays an important role in maintaining intestinal health. Butyric acid has received special attention as a short-chain fatty acid, but its role in protecting the intestinal barrier is poorly characterized. Butyric acid not only provides energy for epithelial cells but also acts as a histone deacetylase inhibitor; it is also a natural ligand for G protein-coupled receptor 109A (GPR109A). A GPR109A analog was expressed in Sus scrofa and mediated the anti-inflammatory effects of beta-hydroxybutyric acid...
2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29941502/sodium-butyrate-supplementation-ameliorates-diabetic-inflammation-in-db-db-mice
#9
You-Hua Xu, Chen-Lin Gao, Heng-Li Guo, Wen-Qian Zhang, Wei Huang, Shan-Shan Tang, Wen-Jun Gan, Yong Xu, Hua Zhou, Quan Zhu
Endotoxemia has been recognized to be closely accompanied with type 2 diabetes mellitus (T2DM) and is responsible for many diabetic complications. Recent study suggests the potential role of butyrate, a short-chain fatty acid (SCFA) from microbiota metabolite, on T2DM. Gut-leak is a key event in diabetic-endotoxemia. To investigate if butyrate could ameliorate diabetic-endotoxemia, both in vivo and in vitro experiments were carried out in the present study. The effect of butyrate supplementation on blood HbA1c and inflammatory cytokines were determined in db/db mice; gut barrier integrity and expression of tight junction proteins were investigated both in vivo and in vitro Oral butyrate administration significantly decreased blood HbA1c, inflammatory cytokines and LPS in db/db mice; inflammatory cell infiltration was reduced, and gut integrity and intercellular adhesion molecules were increased as detected by HE staining, immunohistochemistry and Western blot...
September 2018: Journal of Endocrinology
https://www.readbyqxmd.com/read/29925252/potential-role-of-the-gut-microbiome-in-als-a-systematic-review
#10
Michelle L Wright, Christina Fournier, Madelyn C Houser, Malú Tansey, Jonathan Glass, Vicki Stover Hertzberg
Amyotrophic lateral sclerosis (ALS) etiology and pathophysiology are not well understood. Recent data suggest that dysbiosis of gut microbiota may contribute to ALS etiology and progression. This review aims to explore evidence of associations between gut microbiota and ALS etiology and pathophysiology. Databases were searched for publications relevant to the gut microbiome in ALS. Three publications provided primary evidence of changes in microbiome profiles in ALS. An ALS mouse model revealed damaged tight junction structure and increased permeability in the intestine versus controls along with a shifted microbiome profile, including decreased levels of butyrate-producing bacteria...
January 1, 2018: Biological Research for Nursing
https://www.readbyqxmd.com/read/29923728/intestinal-microbial-and-metabolic-profiling-of-mice-fed-with-high-glucose-and-high-fructose-diets
#11
João C P Silva, Marta Mota, Fátima O Martins, Célia Nogueira, Teresa Gonçalves, Tatiana Carneiro, Joana Pinto, Daniela Duarte, António S Barros, John G Jones, Ana M Gil
Increased sugar intake is implicated in Type-2 diabetes and fatty liver disease; however, the mechanisms through which glucose and fructose promote these conditions are unclear. We hypothesize that alterations in intestinal metabolite and microbiota profiles specific to each monosaccharide are involved. Two groups of six adult C57BL/6 mice were fed for 10-weeks with diets with glucose (G) or fructose (F) as sole carbohydrates, and a third group was fed with a normal chow carbohydrate mixture (N). Fecal metabolites were profiled by nuclear magnetic resonance (NMR) and microbial composition by real-time polymerase chain reaction (qPCR)...
August 3, 2018: Journal of Proteome Research
https://www.readbyqxmd.com/read/29920474/the-short-chain-fatty-acids-and-lipopolysaccharides-status-in-sprague-dawley-rats-fed-with-high-fat-and-high-cholesterol-diet
#12
D Maciejewska, K Skonieczna-Zydecka, A Lukomska, I Gutowska, K Dec, P Kupnicka, J Palma, A Pilutin, W Marlicz, E Stachowska
Short chain fatty acids (SCFA) are produced by the gut microbiota during the fermentation of non-digestible polysaccharides. Diet is a major factor driving the composition and metabolism of the colonic microbiota. The aim of our study was to examine how a fat-rich and cholesterol-rich diet that, which leads to many metabolic disorders, affects the SCFA profile and lipopolysaccharide (LPS) concentration. The experiment was carried out on 72 male, 8-weeks-old Sprague-Dawley rats. The study group (n = 30 rats) received high-fat and high cholesterol diet (HFHCh)...
April 2018: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://www.readbyqxmd.com/read/29900399/the-effect-of-synbiotics-bifidobacterium-infantis-and-milk-oligosaccharides-on-shaping-gut-microbiota-community-structure-and-nash-treatment
#13
Prasant Kumar Jena, Lili Sheng, Nidhi Nagar, Chao Wu, Daniela Barile, David A Mills, Yui-Jui Yvonne Wan
Probiotic Bifidobacterium longum subspecies infantis ( Bifidobacterium infantis ) consumes human milk oligosaccharides (MO) and protects intestinal permeability thereby having anti-inflammatory effects (Underwood et al., 2015; Bode, 2006; Asakuma et al., 2011) [1-3]. Via the gut-liver axis, gut barrier disruption and dysbiosis lead to hepatic inflammation (Sheng et al., 2017; Jena et al., 2017) [4,5,6]. Our published data revealed that butyrate, as well as synbiotics of B. infantis in combination with MO, had protective effects against cancer-prone non-alcoholic steatohepatitis (NASH) mouse models, i...
August 2018: Data in Brief
https://www.readbyqxmd.com/read/29782961/baclofen-induced-encephalopathy-in-overdose-modeling-of-the-electroencephalographic-effect-concentration-relationships-and-contribution-of-tolerance-in-the-rat
#14
Magali Chartier, Isabelle Malissin, Salma Tannous, Laurence Labat, Patricia Risède, Bruno Mégarbane, Lucie Chevillard
Baclofen, a γ-amino-butyric acid type-B receptor agonist with exponentially increased use at high-dose to facilitate abstinence in chronic alcoholics, is responsible for increasing poisonings. Baclofen overdose may induce severe encephalopathy and electroencephalographic (EEG) abnormalities. Whether prior prolonged baclofen treatment may influence the severity of baclofen-induced encephalopathy in overdose has not been established. We designed a rat study to characterize baclofen-induced encephalopathy, correlate its severity with plasma concentrations and investigate the contribution of tolerance...
August 30, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29767727/effects-of-long-term-intake-of-a-yogurt-fermented-with-lactobacillus-delbrueckii-subsp-bulgaricus-2038-and-streptococcus-thermophilus-1131-on-mice
#15
Yuki Usui, Yasumasa Kimura, Takeshi Satoh, Naoki Takemura, Yasuo Ouchi, Hiroko Ohmiya, Kyosuke Kobayashi, Hiromi Suzuki, Satomi Koyama, Satoko Hagiwara, Hirotoshi Tanaka, Seiya Imoto, Gérard Eberl, Yukio Asami, Kosuke Fujimoto, Satoshi Uematsu
The gut is an extremely complicated ecosystem where micro-organisms, nutrients and host cells interact vigorously. Although the function of the intestine and its barrier system weakens with age, some probiotics can potentially prevent age-related intestinal dysfunction. Lactobacillus delbrueckii subsp. bulgaricus 2038 and Streptococcus thermophilus 1131, which are the constituents of LB81 yogurt, are representative probiotics. However, it is unclear whether their long-term intake has a beneficial influence on systemic function...
June 26, 2018: International Immunology
https://www.readbyqxmd.com/read/29712884/imbalance-of-gut-microbiome-and-intestinal-epithelial-barrier-dysfunction-in-cardiovascular-disease
#16
Judith N Lezutekong, Anish Nikhanj, Gavin Y Oudit
The main function of the intestinal barrier is to regulate the absorption of nutrients, electrolytes, and water from the lumen into circulation and to prevent the entry of pathogenic microorganisms and toxic luminal substances. To maintain this function, an ideal microbiota balance is required and gut microbiota are critical for the intestinal epithelial barrier dysfunction and for the maintenance of physiological homeostasis. There is a demonstrable link between dysbiosis and intestinal dysfunction and diseases such as diabetes, obesity, and cardiovascular disease...
April 30, 2018: Clinical Science (1979-)
https://www.readbyqxmd.com/read/29690739/-effects-of-short-chain-fatty-acid-on-barrier-disruption-of-human-intestinal-epithelial-cell-induced-by-endotoxin-lipopolysaccharide-and-the-related-mechanism
#17
Y H Feng, Y L Huang, P Wang, F J Wang
Objective: To investigate the effects of short chain fatty acid (SCFA) on barrier disruption of human intestinal epithelial cell induced by endotoxin/lipopolysaccharide (LPS) and the related mechanism. Methods: The human intestinal epithelial cell line Caco-2 was used to reproduce monolayer-cells. Cells were divided into control group, LPS group, and SCFA+ LPS group according to the random number table. Cells in control group were only routinely cultured with DMEM medium. Cells in LPS group were cultured with DMEM medium and LPS with final mass concentration of 10 μg/mL...
April 20, 2018: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/29690504/selective-inhibition-of-histone-deacetylation-in-melanoma-increases-targeted-gene-delivery-by-a-bacteriophage-viral-vector
#18
Samuel Campbell, Keittisak Suwan, Sajee Waramit, Eric Ofori Aboagye, Amin Hajitou
The previously developed adeno-associated virus/phage (AAVP) vector, a hybrid between M13 bacteriophage (phage) viruses that infect bacteria only and human Adeno-Associated Virus (AAV), is a promising tool in targeted gene therapy against cancer. AAVP can be administered systemically and made tissue specific through the use of ligand-directed targeting. Cancer cells and tumor-associated blood vessels overexpress the αν integrin receptors, which are involved in tumor angiogenesis and tumor invasion...
April 21, 2018: Cancers
https://www.readbyqxmd.com/read/29689277/butyrate-ameliorated-nlrc3-protects-the-intestinal-barrier-in-a-gpr43-dependent-manner
#19
Di Cheng, Ji-Hao Xu, Jie-Yao Li, Si-Yi Wang, Ting-Feng Wu, Qi-Kui Chen, Tao Yu
BACKGROUND: Intestinal barrier dysfunctions are related to dysbacteriosis and chronic gut inflammation in type 2 diabetes. Although there is emerging evidence that the chronic gut inflammatory response is stimulated by nucleotide-binding oligomerization domain-like receptors (NLRs), the relationship and precise mechanism between NLRC3 and the colonic epithelial barrier remains largely elusive. METHODS: We investigated the function and mechanism of NLRC3 in the colonic tissues of diabetic mice and colonic epithelial cell lines...
July 1, 2018: Experimental Cell Research
https://www.readbyqxmd.com/read/29679078/fluorophore-labeling-of-a-cell-penetrating-peptide-significantly-alters-the-mode-and-degree-of-biomembrane-interaction
#20
Sofie Fogh Hedegaard, Mohammed Sobhi Derbas, Tania Kjellerup Lind, Marina Robertnova Kasimova, Malene Vinther Christensen, Maria Høtoft Michaelsen, Richard A Campbell, Lene Jorgensen, Henrik Franzyk, Marité Cárdenas, Hanne Mørck Nielsen
The demand for highly efficient macromolecular drugs, used in the treatment of many severe diseases, is continuously increasing. However, the hydrophilic character and large molecular size of these drugs significantly limit their ability to permeate across cellular membranes and thus impede the drugs in reaching their target sites in the body. Cell-penetrating peptides (CPP) have gained attention as promising drug excipients, since they can facilitate drug permeation across cell membranes constituting a major biological barrier...
April 20, 2018: Scientific Reports
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