Yi-Nan Li, Chih-Wei Chen, Thuong Trinh-Minh, Honglin Zhu, Alexandru-Emil Matei, Andrea-Hermina Györfi, Frederic Kuwert, Philipp Hubel, Xiao Ding, Cuong Tran Manh, Xiaohan Xu, Christoph Liebel, Vladyslav Fedorchenko, Ruifang Liang, Kaiyue Huang, Jens Pfannstiel, Min-Chuan Huang, Neng-Yu Lin, Andreas Ramming, Georg Schett, Jörg H W Distler
Bone mass is maintained by the balance between osteoclast-induced bone resorption and osteoblast-triggered bone formation. In inflammatory arthritis such as rheumatoid arthritis (RA), however, increased osteoclast differentiation and activity skew this balance resulting in progressive bone loss. O-GlcNAcylation is a posttranslational modification with attachment of a single O-linked β-D-N-acetylglucosamine (O-GlcNAc) residue to serine or threonine residues of target proteins. Although O-GlcNAcylation is one of the most common protein modifications, its role in bone homeostasis has not been systematically investigated...
July 26, 2022: Bone Research