Masaharu Hazawa, Dini Kurnia Ikliptikawati, Yuki Iwashima, De-Chen Lin, Yuan Jiang, Yujia Qiu, Kei Makiyama, Koki Matsumoto, Akiko Kobayashi, Goro Nishide, Lim Keesiang, Hironori Yoshino, Toshinari Minamoto, Takeshi Suzuki, Isao Kobayashi, Makiko Meguro-Horike, Yan-Yi Jiang, Takumi Nishiuchi, Hiroki Konno, H Phillip Koeffler, Kazuyoshi Hosomichi, Atsushi Tajima, Shin-Ichi Horike, Richard W Wong
Master transcription factors such as TP63 establish super-enhancers (SEs) to drive core transcriptional networks in cancer cells, yet the spatiotemporal regulation of SEs within the nucleus remains unknown. The nuclear pore complex (NPC) may tether SEs to the nuclear pore where RNA export rates are maximal. Here, we report that NUP153, a component of the NPC, anchors SEs to the NPC and enhances TP63 expression by maximizing mRNA export. This anchoring is mediated through protein-protein interaction between the intrinsically disordered regions (IDRs) of NUP153 and the coactivator BRD4...
October 30, 2023: Cell Chemical Biology