keyword
https://read.qxmd.com/read/38010036/the-temporal-spatial-expression-and-functional-analysis-of-three-gustatory-receptor-genes-in-solenopsis-invicta-using-sweet-and-bitter-compounds
#21
JOURNAL ARTICLE
Muhammad Irfan Waris, Yanyuan Lei, Guojun Qi, Ziying Guan, Abdul Rashied, Jie Chen, Lihua Lyu
The insect gustatory system participates in identifying potential food sources and avoiding toxic compounds. During this process, gustatory receptors (GRs) recognize feeding stimulant and deterrent compounds. However, the GRs involved in recognizing stimulant and deterrent compounds in the red imported fire ant, Solenopsis invicta, remain unknown. Therefore, we conducted a study on the genes SinvGR1, SinvGR32b, and SinvGR28a to investigate the roles of GRs in detecting feeding stimulant and deterrent compounds...
November 27, 2023: Insect Science
https://read.qxmd.com/read/37987957/noninvasive-deep-brain-stimulation-via-temporal-interference-electric-fields-enhanced-motor-performance-of-mice-and-its-neuroplasticity-mechanisms
#22
JOURNAL ARTICLE
Xiaodong Liu, Shuo Qi, Lijuan Hou, Yu Liu, Xiaohui Wang
A noninvasive deep brain stimulation via temporal interference (TI) electric fields is a novel neuromodulation technology, but few advances about TI stimulation effectiveness and mechanisms have been reported. One hundred twenty-six mice were selected for the experiment by power analysis. In the present study, TI stimulation was proved to stimulate noninvasively primary motor cortex (M1) of mice, and 7-day TI stimulation with an envelope frequency of 20 Hz (∆f =20 Hz), instead of an envelope frequency of 10 Hz (∆f =10 Hz), could obviously improve mice motor performance...
November 21, 2023: Molecular Neurobiology
https://read.qxmd.com/read/37957321/publisher-correction-non-invasive-temporal-interference-electrical-stimulation-of-the-human-hippocampus
#23
Ines R Violante, Ketevan Alania, Antonino M Cassarà, Esra Neufeld, Emma Acerbo, Romain Carron, Adam Williamson, Danielle L Kurtin, Edward Rhodes, Adam Hampshire, Niels Kuster, Edward S Boyden, Alvaro Pascual-Leone, Nir Grossman
No abstract text is available yet for this article.
December 2023: Nature Neuroscience
https://read.qxmd.com/read/37956015/fascicle-selective-ultrasound-powered-bidirectional-wireless-peripheral-nerve-interface-ic
#24
JOURNAL ARTICLE
Jianxiong Xu, Jose Sales Filho, Sudip Nag, Liam Long, Eugene Hwang, Camilo Tejeiro, Gerard O'Leary, Yu Huang, Mustafa Kanchwala, Mohammad Abdolrazzaghi, Chenxi Tang, Patty Liu, Yuan Sui, Hao You, Xilin Liu, Jose Zariffa, Roman Genov
This paper presents an innovative, minimally invasive, battery-free, wireless, peripheral nervous system (PNS) neural interface, which seamlessly integrates a millimeter-scale, fascicle-selective integrated circuit (IC) with extraneural recording and stimulating channels. The system also incorporates a wearable interrogator equipped with integrated machine-learning capabilities. This PNS interface is specifically tailored for adaptive neuromodulation therapy, targeting individuals with paralysis, amputation, or chronic medical conditions...
November 13, 2023: IEEE Transactions on Biomedical Circuits and Systems
https://read.qxmd.com/read/37954939/visualizing-interferential-stimulation-of-human-brains
#25
JOURNAL ARTICLE
Yu Huang
INTRODUCTION: Transcranial electrical stimulation (TES) is limited in focally stimulating deep-brain regions, even with optimized stimulation montages. Recently, interferential stimulation (IFS), also known as transcranial temporal interference stimulation (TI, TIS, or tTIS), has drawn much attention in the TES community as both computational and experimental studies show that IFS can reach deep-brain areas. However, the underlying electrodynamics of IFS is complicated and difficult to visualize...
2023: Frontiers in Human Neuroscience
https://read.qxmd.com/read/37923438/hypoxic-and-temporal-variation-in-the-endocrine-disrupting-toxicity-of-perfluorobutanesulfonate-in-marine-medaka-oryzias-melastigma
#26
JOURNAL ARTICLE
Baili Sun, Jing Li, Yachen Bai, Xiangzhen Zhou, Paul K S Lam, Lianguo Chen
Perfluorobutanesulfonate (PFBS) is an emerging pollutant capable of potently disrupting the sex and thyroid endocrine systems of teleosts. However, the hypoxic and temporal variation in PFBS endocrine disrupting toxicity remain largely unknown. In the present study, adult marine medaka were exposed to environmentally realistic concentrations of PFBS (0 and 10 µg/L) under normoxia or hypoxia conditions for 7 days, aiming to explore the interactive behavior between PFBS and hypoxia. In addition, PFBS singular exposure was extended till 21 days under normoxia to elucidate the time-course progression in PFBS toxicity...
February 2024: Journal of Environmental Sciences (China)
https://read.qxmd.com/read/37891801/low-energy-transcranial-navigation-guided-focused-ultrasound-for-neuropathic-pain-an-exploratory-study
#27
JOURNAL ARTICLE
Dong Hoon Shin, Seong Son, Eun Young Kim
Neuromodulation using high-energy focused ultrasound (FUS) has recently been developed for various neurological disorders, including tremors, epilepsy, and neuropathic pain. We investigated the safety and efficacy of low-energy FUS for patients with chronic neuropathic pain. We conducted a prospective single-arm trial with 3-month follow-up using new transcranial, navigation-guided, focused ultrasound (tcNgFUS) technology to stimulate the anterior cingulate cortex. Eleven patients underwent FUS with a frequency of 250 kHz and spatial-peak temporal-average intensity of 0...
October 8, 2023: Brain Sciences
https://read.qxmd.com/read/37879931/-research-progress-on-transcranial-electrical-stimulation-for-deep-brain-stimulation
#28
JOURNAL ARTICLE
Weiyu Meng, Cheng Zhang, Changzhe Wu, Guanghao Zhang, Xiaolin Huo
Transcranial electric stimulation (TES) is a non-invasive, economical, and well-tolerated neuromodulation technique. However, traditional TES is a whole-brain stimulation with a small current, which cannot satisfy the need for effectively focused stimulation of deep brain areas in clinical treatment. With the deepening of the clinical application of TES, researchers have constantly investigated new methods for deeper, more intense, and more focused stimulation, especially multi-electrode stimulation represented by high-precision TES and temporal interference stimulation...
October 25, 2023: Sheng Wu Yi Xue Gong Cheng Xue za Zhi, Journal of Biomedical Engineering, Shengwu Yixue Gongchengxue Zazhi
https://read.qxmd.com/read/37859444/attention-circuits-mediate-the-connection-between-emotional-experience-and-expression-within-the-emotional-circuit
#29
JOURNAL ARTICLE
Na Rae Won, Young-Don Son, Sun Mi Kim, Sujin Bae, Jeong Hee Kim, Jong-Hoon Kim, Doug Hyun Han
OBJECTIVE: : Most affective neuroscience studies use pictures from the International Affective Picture System or standard facial expressions to elicit emotional experiences. The attention system, including the prefrontal cortex, can mediate emotional regulation in response to stimulation with emotional faces. We hypothesized that emotional experience is associated with brain activity within the neocortex. In addition, modification within the neocortex may be associated with brain activity within the attention system...
November 30, 2023: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
https://read.qxmd.com/read/37857775/non-invasive-temporal-interference-electrical-stimulation-of-the-human-hippocampus
#30
JOURNAL ARTICLE
Ines R Violante, Ketevan Alania, Antonino M Cassarà, Esra Neufeld, Emma Acerbo, Romain Carron, Adam Williamson, Danielle L Kurtin, Edward Rhodes, Adam Hampshire, Niels Kuster, Edward S Boyden, Alvaro Pascual-Leone, Nir Grossman
Deep brain stimulation (DBS) via implanted electrodes is used worldwide to treat patients with severe neurological and psychiatric disorders. However, its invasiveness precludes widespread clinical use and deployment in research. Temporal interference (TI) is a strategy for non-invasive steerable DBS using multiple kHz-range electric fields with a difference frequency within the range of neural activity. Here we report the validation of the non-invasive DBS concept in humans. We used electric field modeling and measurements in a human cadaver to verify that the locus of the transcranial TI stimulation can be steerably focused in the hippocampus with minimal exposure to the overlying cortex...
October 19, 2023: Nature Neuroscience
https://read.qxmd.com/read/37857774/noninvasive-theta-burst-stimulation-of-the-human-striatum-enhances-striatal-activity-and-motor-skill-learning
#31
JOURNAL ARTICLE
Maximilian J Wessel, Elena Beanato, Traian Popa, Fabienne Windel, Pierre Vassiliadis, Pauline Menoud, Valeriia Beliaeva, Ines R Violante, Hedjoudje Abderrahmane, Patrycja Dzialecka, Chang-Hyun Park, Pablo Maceira-Elvira, Takuya Morishita, Antonino M Cassara, Melanie Steiner, Nir Grossman, Esra Neufeld, Friedhelm C Hummel
The stimulation of deep brain structures has thus far only been possible with invasive methods. Transcranial electrical temporal interference stimulation (tTIS) is a novel, noninvasive technology that might overcome this limitation. The initial proof-of-concept was obtained through modeling, physics experiments and rodent models. Here we show successful noninvasive neuromodulation of the striatum via tTIS in humans using computational modeling, functional magnetic resonance imaging studies and behavioral evaluations...
November 2023: Nature Neuroscience
https://read.qxmd.com/read/37780965/a-mini-review-recent-advancements-in-temporal-interference-stimulation-in-modulating-brain-function-and-behavior
#32
REVIEW
Zhiqiang Zhu, Lijun Yin
Numerous studies have assessed the effect of Temporal Interference (TI) on human performance. However, a comprehensive literature review has not yet been conducted. Therefore, this review aimed to search PubMed and Web of Science databases for TI-related literature and analyze the findings. We analyzed studies involving preclinical, human, and computer simulations, and then discussed the mechanism and safety of TI. Finally, we identified the gaps and outlined potential future directions. We believe that TI is a promising technology for the treatment of neurological movement disorders, due to its superior focality, steerability, and tolerability compared to traditional electrical stimulation...
2023: Frontiers in Human Neuroscience
https://read.qxmd.com/read/37759918/brain-response-to-interferential-current-compared-with-alternating-current-stimulation
#33
JOURNAL ARTICLE
Zonghao Xin, Yoshifumi Abe, Akihiro Kuwahata, Kenji F Tanaka, Masaki Sekino
Temporal interference (TI) stimulation, which utilizes multiple external electric fields with amplitude modulation for neural modulation, has emerged as a potential noninvasive brain stimulation methodology. However, the clinical application of TI stimulation is inhibited by its uncertain fundamental mechanisms, and research has previously been restricted to numerical simulations and immunohistology without considering the acute in vivo response of the neural circuit. To address the characterization and understanding of the mechanisms underlying the approach, we investigated instantaneous brainwide activation patterns in response to invasive interferential current (IFC) stimulation compared with low-frequency alternative current stimulation (ACS)...
September 13, 2023: Brain Sciences
https://read.qxmd.com/read/37745363/timing-and-location-of-speech-errors-induced-by-direct-cortical-stimulation
#34
Heather Kabakoff, Leyao Yu, Daniel Friedman, Patricia Dugan, Werner K Doyle, Orrin Devinsky, Adeen Flinker
Cortical regions supporting speech production are commonly established using neuroimaging techniques in both research and clinical settings. However, for neurosurgical purposes, structural function is routinely mapped peri-operatively using direct electrocortical stimulation. While this method is the gold standard for identification of eloquent cortical regions to preserve in neurosurgical patients, there is lack of specificity of the actual underlying cognitive processes being interrupted. To address this, we propose mapping the temporal dynamics of speech arrest across peri-sylvian cortices by quantifying the latency between stimulation and speech deficits...
September 15, 2023: bioRxiv
https://read.qxmd.com/read/37716638/effect-of-temporal-interference-electrical-stimulation-on-phasic-dopamine-release-in-the-striatum
#35
JOURNAL ARTICLE
Youngjong Kwak, Seokbeen Lim, Hyun-U Cho, Jeongeun Sim, Sangjun Lee, Suhyeon Jeong, Se Jin Jeon, Chang-Hwan Im, Dong Pyo Jang
BACKGROUND: Temporal interference stimulation (TIS) is a neuromodulation technique that could stimulate deep brain regions by inducing interfering electrical signals based on high-frequency electrical stimulations of multiple electrode pairs from outside the brain. Despite numerous TIS studies, however, there has been limited investigation into the neurochemical effects of TIS. OBJECTIVE: We performed two experiments to investigate the effect of TIS on the medial forebrain bundle (MFB)-evoked phasic dopamine (DA) response...
September 14, 2023: Brain Stimulation
https://read.qxmd.com/read/37696453/cathodal-high-definition-transcranial-direct-current-stimulation-hd-tdcs-of-the-left-ventral-prefrontal-cortex-vpfc-interferes-with-conscious-error-correction
#36
JOURNAL ARTICLE
Bettina Pollok, Carina Depperschmidt, Maximilian Köster, Tobias Schmidt-Wilcke, Vanessa Krause
Precise motor timing requires the ability to flexibly adapt one's own movements with respect to changes in the environment. Previous studies suggest that the correction of perceived as compared to non-perceived timing errors involves at least partially distinct brain networks. The dorsolateral prefrontal cortex (dPFC) has been linked to the correction of perceived timing errors and evidence for a contribution of the ventrolateral PFC (vPFC) specifically to the correction of non-perceived errors exists. The present study aimed at clarifying the functional contribution of the left vPFC for the correction of timing errors by adopting high-definition transcranial direct current stimulation (HD-tDCS)...
September 9, 2023: Behavioural Brain Research
https://read.qxmd.com/read/37693544/optodyce-plate-as-an-affordable-high-throughput-imager-for-all-optical-cardiac-electrophysiology
#37
Yuli W Heinson, Julie L Han, Emilia Entcheva
We present a simple low-cost system for comprehensive functional characterization of cardiac function under spontaneous and paced conditions, in standard 96 and 384-well plates. This full-plate actuator/imager, OptoDyCE-plate, uses optogenetic stimulation and optical readouts of voltage and calcium from all wells in parallel. The system is validated with syncytia of human induced pluripotent stem cell derived cardiomyocytes, iPSC-CMs, grown as monolayers, or in quasi-3D isotropic and anisotropic constructs using electrospun matrices, in 96 and 394-well format...
August 31, 2023: bioRxiv
https://read.qxmd.com/read/37673389/the-role-of-ccptgs2a-in-immune-response-against-aeromonas-hydrophila-infection-in-common-carp-cyprinus-carpio
#38
JOURNAL ARTICLE
Feng Gao, Xiaowei Shi, Yanjing Zhao, Dan Qiao, Chao Pei, Chen Li, Xianliang Zhao, Xianghui Kong
Prostaglandin-endoperoxide synthase 2 (PTGS2), a crucial enzyme in prostaglandin synthesis, catalyzes the conversion of arachidonic acid to prostaglandins and plays a significant role in the inflammatory response. This investigation aimed to determine the regulatory role of PTGS2a in the innate immune response to bacterial infection in fish. To achieve this objective, the CcPTGS2a gene was identified and characterized in common carp (Cyprinus carpio), and its function in immune defense was investigated. According to the sequence and structural analysis results, CcPTGS2a had an open reading frame of 1806 bp that encoded 602 amino acids...
September 4, 2023: Fish & Shellfish Immunology
https://read.qxmd.com/read/37665696/a-real-time-non-implantation-bi-directional-brain-computer-interface-solution-without-stimulation-artifacts
#39
JOURNAL ARTICLE
Yike Sun, Anruo Shen, Chenlin Du, Jingnan Sun, Xiaogang Chen, Xiaorong Gao
The non-implantation bi-directional brain-computer interface (BCI) is a neural interface technology that enables direct two-way communication between the brain and the external world by both "reading" neural signals and "writing" stimulation patterns to the brain. This technology has vast potential applications, such as improving the quality of life for individuals with neurological and mental illnesses and even expanding the boundaries of human capabilities. Nonetheless, non-implantation bi-directional BCIs face challenges in generating real-time feedback and achieving compatibility between stimulation and recording...
September 4, 2023: IEEE Transactions on Neural Systems and Rehabilitation Engineering
https://read.qxmd.com/read/37604295/multi-objective-optimization-via-evolutionary-algorithm-movea-for-high-definition-transcranial-electrical-stimulation-of-the-human-brain
#40
JOURNAL ARTICLE
Mo Wang, Kexin Lou, Zeming Liu, Pengfei Wei, Quanying Liu
Designing a transcranial electrical stimulation (tES) strategy requires considering multiple objectives, such as intensity in the target area, focality, stimulation depth, and avoidance zone. These objectives are often mutually exclusive. In this paper, we propose a general framework, called multi-objective optimization via evolutionary algorithm (MOVEA), which solves the non-convex optimization problem in designing tES strategies without a predefined direction. MOVEA enables simultaneous optimization of multiple targets through Pareto optimization, generating a Pareto front after a single run without manual weight adjustment and allowing easy expansion to more targets...
October 15, 2023: NeuroImage
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