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Temporal interference stimulation

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https://www.readbyqxmd.com/read/30411178/repetitive-transcranial-magnetic-stimulation-over-the-left-posterior-middle-temporal-gyrus-reduces-wrist-velocity-during-emblematic-hand-gesture-imitation
#1
Arran T Reader, Nicholas P Holmes
Results from neuropsychological studies, and neuroimaging and behavioural experiments with healthy individuals, suggest that the imitation of meaningful and meaningless actions may be reliant on different processing routes. The left posterior middle temporal gyrus (pMTG) is one area that might be important for the recognition and imitation of meaningful actions. We studied the role of the left pMTG in imitation using repetitive transcranial magnetic stimulation (rTMS) and two-person motion-tracking. Participants imitated meaningless and emblematic meaningful hand and finger gestures performed by a confederate actor whilst both individuals were motion-tracked...
November 8, 2018: Brain Topography
https://www.readbyqxmd.com/read/30390658/effects-of-disparity-on-visual-discomfort-caused-by-short-term-stereoscopic-viewing-based-on-electroencephalograph-analysis
#2
Xiao Wang, Liuye Yao, Yuemei Zhao, Lidong Xing, Zhiyu Qian, Weitao Li, Yamin Yang
BACKGROUND: Discomfort evoked by stereoscopic depth has been widely concerned. Previous studies have proposed a comfortable disparity range and considered that disparities exceed this range would cause visual discomfort. Brain activity recordings including Electroencephalograph (EEG) monitoring enable better understanding of perceptual and cognitive processes related to stereo depth-induced visual comfort. METHODS: EEG data was collected using a stereo-visual evoked potential (VEP) test system by providing visual stimulus to subjects aged from 21 to 25 with normal stereoscopic vision...
November 3, 2018: Biomedical Engineering Online
https://www.readbyqxmd.com/read/30264149/translating-temporal-interference-brain-stimulation-to-treat-neurological-and-psychiatric-conditions
#3
Nir Grossman, Michael S Okun, Edward S Boyden
No abstract text is available yet for this article.
November 1, 2018: JAMA Neurology
https://www.readbyqxmd.com/read/29963983/control-of-cyclic-oligoadenylate-synthesis-in-a-type-iii-crispr-system
#4
Christophe Rouillon, Januka S Athukoralage, Shirley Graham, Sabine Grüschow, Malcolm F White
The CRISPR system for prokaryotic adaptive immunity provides RNA-mediated protection from viruses and mobile genetic elements. When viral RNA transcripts are detected, type III systems adopt an activated state that licenses DNA interference and synthesis of cyclic oligoadenylate (cOA). cOA activates nucleases and transcription factors that orchestrate the antiviral response. We demonstrate that cOA synthesis is subject to tight temporal control, commencing on target RNA binding, and is deactivated rapidly as target RNA is cleaved and dissociates...
July 2, 2018: ELife
https://www.readbyqxmd.com/read/29929005/establishing-the-functional-connectivity-of-the-frontotemporal-network-in-pre-attentive-change-detection-with-transcranial-magnetic-stimulation-and-event-related-optical-signal
#5
Chun-Yu Tse, Long-Yin Yip, Troby Ka-Yan Lui, Xue-Zhen Xiao, Yang Wang, Winnie Chiu Wing Chu, Nathan Allen Parks, Sandra Sau-Man Chan, Sebastiaan Franciscus Wijnandus Neggers
Current theories of pre-attentive deviant detection postulate that before the Superior Temporal Cortex (STC) detects a change, the Inferior Frontal Cortex (IFC) engages in stimulus analysis, which is particularly critical for ambiguous deviations (e.g., deviant preceded by a short train of standards). These theories rest on the assumption that IFC and STC are functionally connected, which has only been supported by correlational brain imaging studies. We examined this functional connectivity assumption by applying Transcranial Magnetic Stimulation (TMS) to disrupt IFC function, while measuring the later STC mismatch response with the event-related optical signal (EROS)...
October 1, 2018: NeuroImage
https://www.readbyqxmd.com/read/29916788/decoupling-of-early-v5-motion-processing-from-visual-awareness-a-matter-of-velocity-as-revealed-by-transcranial-magnetic-stimulation
#6
Paolo A Grasso, Elisabetta Làdavas, Caterina Bertini, Serena Caltabiano, Gregor Thut, Stephanie Morand
Motion information can reach V5/MT through two parallel routes: one conveying information at early latencies through a direct subcortical route and the other reaching V5 later via recurrent projections through V1. Here, we tested the hypothesis that input via the faster direct pathway depends on motion characteristics. To this end, we presented motion stimuli to healthy human observers at different velocities (4.4°/sec vs. 23°/sec) with static stimuli as controls while applying transcranial magnetic stimulation (TMS) pulses over V5 or V1...
October 2018: Journal of Cognitive Neuroscience
https://www.readbyqxmd.com/read/29910706/less-might-be-more-conduction-failure-as-a-factor-possibly-limiting-the-efficacy-of-higher-frequencies-in-rtms-protocols
#7
Islam Halawa, Amir Goldental, Yuichiro Shirota, Ido Kanter, Walter Paulus
Introduction: rTMS has been proven effective in the treatment of neuropsychiatric conditions, with class A (definite efficacy) evidence for treatment of depression and pain (Lefaucheur et al., 2014). The efficacy in stimulation protocols is, however, quite heterogeneous. Saturation of neuronal firing by HFrTMS without allowing time for recovery may lead to neuronal response failures (NRFs) that compromise the efficacy of stimulation with higher frequencies. Objectives: To examine the efficacy of different rTMS temporal stimulation patterns focusing on a possible upper stimulation limit related to response failures...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29756178/hippocampal-deep-brain-stimulation-persistent-seizure-control-after-bilateral-extra-cranial-electrode-fracture
#8
Massimo Piacentino, Giacomo Beggio, Lara Zordan, Paolo Bonanni
Hippocampal deep brain stimulation (DBS) can provide an effective alternative for intractable temporal lobe epilepsy. In this case report, we describe a peculiar outcome after a post-traumatic wire-disconnection of a bilateral hippocampal DBS device. The patient presented a postoperative long-term significant reduction in seizure frequency even with an absent electric stimulation. This case gives the possibility to consider alternatives in epilepsy surgery, based on stimulation interference (lesional or electrical disturbing) in the epileptogenic zone...
August 2018: Neurological Sciences
https://www.readbyqxmd.com/read/29702184/multisensory-vestibular-vestibular-auditory-and-auditory-network-effects-revealed-by-parametric-sound-pressure-stimulation
#9
Sun-Young Oh, Rainer Boegle, Matthias Ertl, Thomas Stephan, Marianne Dieterich
Multisensory convergence and sensorimotor integration are important aspects for the mediation of higher vestibular cognitive functions at the cortical level. In contrast to the integration of vestibulo-visual or vestibulo-tactile perception, much less is known about the neural mechanism that mediates the integration of vestibular-otolith (linear acceleration/translation/gravity detection) and auditory processing. Vestibular-otolith and auditory afferents can be simultaneously activated using loud sound pressure stimulation, which is routinely used for testing cervical and ocular vestibular evoked myogenic potentials (VEMPs) in clinical neurotological testing...
August 1, 2018: NeuroImage
https://www.readbyqxmd.com/read/29690546/a-rationale-for-music-training-to-enhance-executive-functions-in-parkinson-s-disease-an-overview-of-the-problem
#10
Teresa Lesiuk, Jennifer A Bugos, Brea Murakami
Music listening interventions such as Rhythmic Auditory Stimulation can improve mobility, balance, and gait in Parkinson’s Disease (PD). Yet, the impact of music training on executive functions is not yet known. Deficits in executive functions (e.g., attention, processing speed) in patients with PD result in gait interference, deficits in emotional processing, loss of functional capacity (e.g., intellectual activity, social participation), and reduced quality of life. The model of temporal prediction and timing suggests two networks collectively contribute to movement generation and execution: the basal ganglia-thalamocortical network (BGTC) and the cerebellar-thalamocortical network (CTC)...
April 22, 2018: Healthcare (Basel, Switzerland)
https://www.readbyqxmd.com/read/29606416/mechanisms-underlying-decision-making-as-revealed-by-deep-brain-stimulation-in-patients-with-parkinson-s-disease
#11
Damian M Herz, Simon Little, David J Pedrosa, Gerd Tinkhauser, Binith Cheeran, Tom Foltynie, Rafal Bogacz, Peter Brown
To optimally balance opposing demands of speed and accuracy during decision-making, we must flexibly adapt how much evidence we require before making a choice. Such adjustments in decision thresholds have been linked to the subthalamic nucleus (STN), and therapeutic STN deep-brain stimulation (DBS) has been shown to interfere with this function. Here, we performed continuous as well as closed-loop DBS of the STN while Parkinson's disease patients performed a perceptual decision-making task. Closed-loop STN DBS allowed temporally patterned STN stimulation and simultaneous recordings of STN activity...
April 23, 2018: Current Biology: CB
https://www.readbyqxmd.com/read/29460482/electrocorticographic-high-gamma-modulation-with-passive-listening-paradigm-for-pediatric-extraoperative-language-mapping
#12
Ravindra Arya, J Adam Wilson, Hisako Fujiwara, Jennifer Vannest, Anna W Byars, Leonid Rozhkov, James L Leach, Hansel M Greiner, Jason Buroker, Craig Scholle, Paul S Horn, Nathan E Crone, Douglas F Rose, Francesco T Mangano, Katherine D Holland
OBJECTIVE: This prospective study compared the topography of high-gamma modulation (HGM) during a story-listening task requiring negligible patient cooperation, with the conventional electrical stimulation mapping (ESM) using a picture-naming task, for presurgical language localization in pediatric drug-resistant epilepsy. METHODS: Patients undergoing extraoperative monitoring with subdural electrodes were included. Electrocorticographic signals were recorded during quiet baseline and a story-listening task...
April 2018: Epilepsia
https://www.readbyqxmd.com/read/29410266/visual-sensorimotor-and-cognitive-routes-to-understanding-others-enjoyment-an-individual-differences-rtms-approach-to-empathic-accuracy
#13
Riccardo Paracampo, Martina Pirruccio, Marco Costa, Sara Borgomaneri, Alessio Avenanti
Functional imaging studies suggest that accurate understanding of others' emotional feelings (i.e., empathic accuracy, EA) recruits high-order visual, sensorimotor and mentalizing brain networks. However, the behavioral relevance of these findings is unclear. To fill in this gap, we used repetitive transcranial magnetic stimulation (rTMS) to interfere with the right superior temporal sulcus (STS), inferior frontal gyrus (IFG) and temporoparietal junction (TPJ) during an EA task requiring participants to infer the enjoyment felt by a social target while smiling/laughing...
July 31, 2018: Neuropsychologia
https://www.readbyqxmd.com/read/29390108/dural-and-pial-pain-sensitive-structures-in-humans-new-inputs-from-awake-craniotomies
#14
Denys Fontaine, Fabien Almairac, Serena Santucci, Charlotte Fernandez, Radhouane Dallel, Johan Pallud, Michel Lanteri-Minet
Our knowledge on intracranial pain-sensitive structures in humans comes essentially from observations during neurosurgical procedures performed in awake patients. It is currently accepted that intracranial pain-sensitive structures are limited to the dura mater and its feeding vessels and that small cerebral vessels and pia mater are insensitive to pain, which is inconsistent with some neurosurgical observations during awake craniotomy procedures. We prospectively collected observations of painful events evoked by mechanical stimulation (touching, stretching, pressure, or aspiration) of intracranial structures during awake craniotomies, routinely performed for intraoperative functional mapping to tailor brain tumour resection in the eloquent area...
April 1, 2018: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29354783/expression-analysis-of-interferon-stimulated-gene-15-in-the-rock-bream-oplegnathus-fasciatus-against-rock-bream-iridovirus-rsiv-challenge
#15
Kyung-Hee Kim, In Jung Yang, Woo-Jin Kim, Choul-Ji Park, Jong-Won Park, Gyeong Eon Noh, Seunghyung Lee, Young Mee Lee, Hyung Kyu Hwang, Hyun Chul Kim
Interferon-stimulated gene 15 (ISG15) is known to interfere with viral replication and infection by limiting the viral infection of cells. Interferon-stimulated gene 15 (ISG15) interferes with viral replication and infectivity by limiting viral infection in cells. It also plays an important role in the immune response. In this study, tissue-specific expression of ISG15 in healthy rock bream samples and spatial and temporal expression analysis of rock bream ISG15 (RbISG15) were performed following rock bream iridovirus (RSIV) infection...
December 2017: Balsaeng'gwa Saengsig
https://www.readbyqxmd.com/read/29352255/offline-stimulation-of-human-parietal-cortex-differently-affects-resting-eeg-microstates
#16
Pierpaolo Croce, Filippo Zappasodi, Paolo Capotosto
The interference effects of transcranial magnetic stimulation (TMS) on several electroencephalographic (EEG) measures in both temporal and frequency domains have been reported. We tested the hypothesis whether the offline external inhibitory interference, although focal, could result in a global reorganization of the functional brain state, as assessed by EEG microstates. In 16 healthy subjects, we inhibited five parietal areas and used a pseudo stimulation (Sham) at rest. The EEG microstates were extracted before and after each stimulation...
January 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29211650/selective-interference-with-syntactic-encoding-during-sentence-production-by-direct-electrocortical-stimulation-of-the-inferior-frontal-gyrus
#17
Edward F Chang, Garret Kurteff, Stephen M Wilson
Cortical stimulation mapping (CSM) has provided important insights into the neuroanatomy of language because of its high spatial and temporal resolution, and the causal relationships that can be inferred from transient disruption of specific functions. Almost all CSM studies to date have focused on word-level processes such as naming, comprehension, and repetition. In this study, we used CSM to identify sites where stimulation interfered selectively with syntactic encoding during sentence production. Fourteen patients undergoing left-hemisphere neurosurgery participated in the study...
March 2018: Journal of Cognitive Neuroscience
https://www.readbyqxmd.com/read/28775255/an-analysis-of-signal-processing-algorithm-performance-for-cortical-intrinsic-optical-signal-imaging-and-strategies-for-algorithm-selection
#18
J A Turley, K Zalewska, M Nilsson, F R Walker, S J Johnson
Intrinsic Optical Signal (IOS) imaging has been used extensively to examine activity-related changes within the cerebral cortex. A significant technical challenge with IOS imaging is the presence of large noise, artefact components and periodic interference. Signal processing is therefore important in obtaining quality IOS imaging results. Several signal processing techniques have been deployed, however, the performance of these approaches for IOS imaging has never been directly compared. The current study aims to compare signal processing techniques that can be used when quantifying stimuli-response IOS imaging data...
August 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28757003/transcranial-direct-current-stimulation-tdcs-modulation-of-picture-naming-and-word-reading-a-meta-analysis-of-single-session-tdcs-applied-to-healthy-participants
#19
REVIEW
Samuel J Westwood, Cristina Romani
Recent reviews quantifying the effects of single sessions of transcranial direct current stimulation (or tDCS) in healthy volunteers find only minor effects on cognition despite the popularity of this technique. Here, we wanted to quantify the effects of tDCS on language production tasks that measure word reading and picture naming. We reviewed 14 papers measuring tDCS effects across a total of 96 conditions to a) quantify effects of conventional stimulation on language regions (i.e., left hemisphere anodal tDCS administered to temporal/frontal areas) under normal conditions or under conditions of cognitive (semantic) interference; b) identify parameters which may moderate the size of the tDCS effect within conventional stimulation protocols (e...
September 2017: Neuropsychologia
https://www.readbyqxmd.com/read/28629874/neural-activity-during-attentional-conflict-predicts-reduction-in-tinnitus-perception-following-rtms
#20
RANDOMIZED CONTROLLED TRIAL
G A James, J D Thostenson, G Brown, G Carter, H Hayes, S P Tripathi, D J Dobry, R B Govindan, J L Dornhoffer, D K Williams, C D Kilts, M S Mennemeier
BACKGROUND: Subjective idiopathic tinnitus is an intrusive, distracting, and potentially disabling disorder characterized by phantom perception of sounds. Although tinnitus has no approved pharmacologic treatment, recent evidence supports the use of repetitive transcranial magnetic stimulation (rTMS) to alleviate tinnitus symptoms. OBJECTIVE/HYPOTHESIS: Repetitive TMS delivered over the middle superior temporal gyrus (STG) may alter ratings of tinnitus awareness and annoyance more than loudness due to change in attentional processing...
September 2017: Brain Stimulation
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