keyword
https://read.qxmd.com/read/38534254/advancing-point-of-care-diagnosis-digitalizing-combinatorial-biomarker-signals-for-lupus-nephritis
#1
JOURNAL ARTICLE
Jiechang Guo, Aygun Teymur, Chenling Tang, Ramesh Saxena, Tianfu Wu
To improve the efficiency and patient coverage of the current healthcare system, user-friendly novel homecare devices are urgently needed. In this work, we developed a smartphone-based analyzing and reporting system (SBARS) for biomarker detection in lupus nephritis (LN). This system offers a cost-effective alternative to traditional, expensive large equipment in signal detection and quantification. This innovative approach involves using a portable and affordable microscopic reader to capture biomarker signals...
March 18, 2024: Biosensors
https://read.qxmd.com/read/38496018/the-significance-of-biomarkers-of-inflammation-in-predicting-the-activity-of-lupus-nephritis
#2
JOURNAL ARTICLE
Violeta Rabrenović, Milica Petrović, Milorad Rabrenović, Dejan Pilčević, Nemanja Rančić
BACKGROUND: Lupus nephritis (LN) is one of the most severe manifestations of systemic lupus erythematosus (SLE). There are increased studies examining the role of different markers that would facilitate diagnosis, LN activity monitoring, relapse occurrence, and the right time to introduce maintenance therapy. We aimed to examine the importance of determining the neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), systemic immuneinflammatory index (SII) and systemic inflammatory response index (SIRI) in LN, comparing their significance with other standard parameters of active disease...
January 25, 2024: Journal of Medical Biochemistry
https://read.qxmd.com/read/38493322/noninvasive-biomarkers-for-lupus-nephritis
#3
JOURNAL ARTICLE
Ting Liu, Yun-Long Yang, Yan Zhou, Yong-Mei Jiang
Lupus nephritis (LN) is one of the most severe clinical manifestations of systemic lupus erythematosus (SLE). Notably, the clinical manifestations of LN are not always consistent with the histopathological findings. Therefore, the diagnosis and activity monitoring of this disease are challenging and largely depend on invasive renal biopsy. Renal biopsy has side effects and is associated with the risk of bleeding and infection. There is a growing interest in the development of novel noninvasive biomarkers for LN...
March 17, 2024: Laboratory Medicine
https://read.qxmd.com/read/38488666/data-processing-solutions-to-render-metabolomics-more-quantitative-case-studies-in-food-and-clinical-metabolomics-using-metabox-2-0
#4
JOURNAL ARTICLE
Kwanjeera Wanichthanarak, Ammarin In-On, Sili Fan, Oliver Fiehn, Arporn Wangwiwatsin, Sakda Khoomrung
In classic semiquantitative metabolomics, metabolite intensities are affected by biological factors and other unwanted variations. A systematic evaluation of the data processing methods is crucial to identify adequate processing procedures for a given experimental setup. Current comparative studies are mostly focused on peak area data but not on absolute concentrations. In this study, we evaluated data processing methods to produce outputs that were most similar to the corresponding absolute quantified data...
January 2, 2024: GigaScience
https://read.qxmd.com/read/38462157/the-role-of-podocytes-in-lupus-nephritis-insights-and-implications
#5
REVIEW
Kunihiro Ichinose
Lupus nephritis (LN) is a severe complication of systemic lupus erythematosus, with high mortality rates despite medical advancements. The complexity of its pathogenesis, including the pivotal role of podocytes - kidney-localized cells - remains a challenge, lacking effective treatments and biomarkers. Recent studies highlight the significant contribution of these cells to LN's development, particularly through their immune-related functions and interaction with other kidney cells. This new understanding opens possibilities for targeted therapies aimed at these cellular mechanisms...
March 8, 2024: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/38455045/comprehensive-analysis-of-lactate-related-gene-profiles-and-immune-characteristics-in-lupus-nephritis
#6
JOURNAL ARTICLE
Zhan Sun, Zhanyan Gao, Mengmeng Xiang, Yang Feng, Jie Wang, Jinhua Xu, Yilun Wang, Jun Liang
OBJECTIVES: The most frequent cause of kidney damage in systemic lupus erythematosus (SLE) is lupus nephritis (LN), which is also a significant risk factor for morbidity and mortality. Lactate metabolism and protein lactylation might be related to the development of LN. However, there is still a lack of relative research to prove the hypothesis. Hence, this study was conducted to screen the lactate-related biomarkers for LN and analyze the underlying mechanism. METHODS: To identify differentially expressed genes (DEGs) in the training set (GSE32591, GSE127797), we conducted a differential expression analysis (LN samples versus normal samples)...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38443092/systemic-lupus-in-the-era-of-machine-learning-medicine
#7
REVIEW
Kevin Zhan, Katherine A Buhler, Irene Y Chen, Marvin J Fritzler, May Y Choi
Artificial intelligence and machine learning applications are emerging as transformative technologies in medicine. With greater access to a diverse range of big datasets, researchers are turning to these powerful techniques for data analysis. Machine learning can reveal patterns and interactions between variables in large and complex datasets more accurately and efficiently than traditional statistical methods. Machine learning approaches open new possibilities for studying SLE, a multifactorial, highly heterogeneous and complex disease...
March 4, 2024: Lupus Science & Medicine
https://read.qxmd.com/read/38409788/identification-of-new-hub-ferroptosis-related%C3%A2-genes-in-lupus-nephritis
#8
JOURNAL ARTICLE
Xiao-Jie Zheng, Ying Chen, Li Yao, Xiao-Li Li, Da Sun, Yan-Qiu Li
Background : Lupus Nephritis (LN) is the primary causation of kidney injury in systemic lupus erythematosus (SLE). Ferroptosis is a programmed cell death. Therefore, understanding the crosstalk between LN and ferroptosis is still a significant challenge. Methods : We obtained the expression profile of LN kidney biopsy samples from the Gene Expression Omnibus database and utilised the R-project software to identify differentially expressed genes (DEGs). Then, we conducted a functional correlation analysis. Ferroptosis-related genes (FRGs) and differentially expressed genes (DEGs) crossover to select FRGs with LN...
December 2024: Autoimmunity
https://read.qxmd.com/read/38409421/kidney-disease-and-proteomics-a-recent-overview-of-a-useful-tool-for-improving-early-diagnosis
#9
JOURNAL ARTICLE
Nicolly Emanuelle de Souza Barcelos, Maria Laura Limeres, Ana Flavia Peixoto-Dias, Maria Aparecida Ribeiro Vieira, Diogo B Peruchetti
Kidney disease is a critical and potentially life-threatening degenerative condition that poses a significant global public health challenge due to its elevated rates of morbidity and mortality. It manifests primarily in two distinct clinical forms: acute kidney injury (AKI) and chronic kidney disease (CKD). The development of these conditions hinges on a multitude of factors, including the etiological agents and the presence of coexisting medical conditions. Despite disparities in their underlying pathogenic mechanisms, both AKI and CKD can progress to end-stage kidney disease (ESKD)...
2024: Advances in Experimental Medicine and Biology
https://read.qxmd.com/read/38396703/serological-antibodies-against-kidney-liver-and-spleen-membrane-antigens-as-potential-biomarkers-in-patients-with-immune-disorders
#10
JOURNAL ARTICLE
Leidi Hernandez-Suarez, Eguzkiñe Diez-Martin, June Egiguren-Ortiz, Roberto Fernandez, Aitor Etxebarria, Egoitz Astigarraga, Cristina Miguelez, Andoni Ramirez-Garcia, Gabriel Barreda-Gómez
Immune disorders arise from complex genetic and environmental factors, which lead to dysregulation at the cellular and inflammatory levels and cause tissue damage. Recent research highlights the crucial role of reactive antibodies in autoimmune diseases and graft rejection, but their complex determination poses challenges for clinical use. Therefore, our study aimed to ascertain whether the presence of reactive antibodies against membrane antigens in tissues from both animal models and humans could serve as biomarkers in patients with autoimmune disorders...
February 7, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38355214/potential-involvement-of-circulating-exosomal-mirna-146a-in-disease-activity-and-traf6-gene-expression-in-juvenile-proliferative-lupus-nephritis
#11
JOURNAL ARTICLE
Poorichaya Somparn, Aunaymon Srichaimongkol, Suwaphit Jungjing, Bunsita Wanthong, Saharat Nanthawong, Leelahavanichkul Asada, Marut Tangwattanachuleepron, Pornpimol Rianthavorn
BACKGROUND: Juvenile SLE (JSLE) is a complex autoimmune disorder that predominantly affects children and adolescents with several unique challenges, and microRNA-146a (miRNA-146a) might be an interesting anti-inflammatory molecule. Because exosomes in the blood might protect miRNAs, the association between circulating exosomal miRNA-146a and lupus proinflammatory genes, such as IRAK1 and TRAF6 , was studied in peripheral blood mononuclear cells from people with JSLE. METHODS: Blood samples from 12 patients were collected every 3 months until 1 year with the recorded disease activity, and quantitative real-time PCR was used to determine the circulating exosomal miRNA-146a and the gene expression ( IRAK1 and TRAF6 )...
February 14, 2024: Lupus Science & Medicine
https://read.qxmd.com/read/38317756/kidney-biopsy-in-management-of-lupus-nephritis-a-case-based-narrative-review
#12
REVIEW
Sonia Rodriguez-Ramirez, Nasim Wiegley, Juan Manuel Mejia-Vilet
Kidney involvement in patients with lupus highly increases morbidity and mortality. In recent years, several reports have emphasized the dissociation between clinical and histological findings and highlighted the role of kidney biopsy as an instrument for diagnosis and follow-up of lupus nephritis. The kidney biopsy at initial diagnosis allows an early diagnosis, assessment of activity and chronicity, and detection of nonimmune complex nephritis. A kidney biopsy repeated months after treatment aids in the detection of persistent histological inflammation, which has been linked to the occurrence of future kidney relapses...
February 2024: Kidney medicine
https://read.qxmd.com/read/38317459/study-of-microrna-124-in-patients-with-lupus-nephritis
#13
JOURNAL ARTICLE
Mostafa Abdelsalam, Maysaa El Sayed Zaki, Nermin Youssef Abo El-Kheir, Mona Foda Salama, Asmaa Osama Bakr Seddik Osman
BACKGROUND: Lupus nephritis is associated with a six-fold increase in mortality compared with the general population. MicroRNAs studies revealed that increased MicroRNA -21 and MicroRNA -155 levels represent risk factors for active LN patients. MicroRNAs can be used as biomarkers in the diagnosis of clinical stages of LN. OBJECTIVES: The present study aimed to determine the level of miR-124 in patients with lupus nephritis by reverse transcriptase real-time polymerase chain reaction compared to healthy control and correlate its levels with biochemical findings in those patients...
January 15, 2024: Endocrine, Metabolic & Immune Disorders Drug Targets
https://read.qxmd.com/read/38313309/urinary-biomarkers-associated-with-podocyte-injury-in-lupus-nephritis
#14
REVIEW
Zhiying Guo, Qianyu Guo, Xiaochen Li, Xinnan Gao, Liyun Zhang, Ke Xu
The most prevalent and devastating form of organ damage in systemic lupus erythematosus (SLE) is lupus nephritis (LN). LN is characterized by glomerular injury, inflammation, cell proliferation, and necrosis, leading to podocyte injury and tubular epithelial cell damage. Assays for urine biomarkers have demonstrated significant promise in the early detection of LN, evaluation of disease activity, and tracking of reaction to therapy. This is because they are non-invasive, allow for frequent monitoring and easy self-collection, transport and storage...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38299415/assessment-of-interleukin-17-in-egyptian-systemic-lupus-erythematosus-patients-as-a-biomarker-in-disease-activity
#15
JOURNAL ARTICLE
Mervat Behiry, Mary Wadie, Nagwa Abdelghaffar Mohamed, Rania Farid, Hala Ramadan
INTRODUCTION: Systemic lupus erythematosus (SLE) is a chronic idiopathic systemic autoimmune disorder with dysregulation of adaptive and innate immune systems. Interleukin (IL)-17 is the prototypical pro-inflammatory cytokine of T helper 17 (Th17) cells. Therefore, it contributes to the pathogenesis of human SLE. AIM: The aim of the research paper was the evaluation of IL-17 level as a biomarker in the SLE cohort and its relation to disease activity and analysis of IL-17 concentration in patients with lupus nephritis and non-lupus nephritis...
January 30, 2024: Current Rheumatology Reviews
https://read.qxmd.com/read/38299290/identification-of-novel-hub-genes-associated-with-inflammation-and-autophagy-in-astragaloside-membranaceus-ameliorates-lupus-nephritis-by-bioinformatics-analysis-and-molecular-dynamics-simulation
#16
JOURNAL ARTICLE
Kaili Kong, Xiaomei Qiao, Ting Liu, Xiaoxia Wang, Rui Li, Jingai Fang, Xiaodong Zhang
BACKGROUND: Lupus nephritis is an autoimmune disease, and its pathogenesis involves inflammation and autophagy disorders. Studies have demonstrated that Astragalus membranaceus can effectively suppress the progression of LN, but the underlying therapeutic target is still unclear. OBJECTION: This study aimed to investigate the therapeutic target whereby AM ameliorates LN. METHOD: We downloaded AM and LN-related chips from the TCMSP and GEO databases, respectively...
January 30, 2024: Combinatorial Chemistry & High Throughput Screening
https://read.qxmd.com/read/38294724/clinico-serological-associations-of-urinary-activated-leukocyte-cell-adhesion-molecule-in-systemic-lupus-erythematosus-and-lupus-nephritis
#17
JOURNAL ARTICLE
Arwa S Amer, Samia M Abdel Moneam, Nashwa I Hashaad, Eman M Yousef, Dalia M Abd El-Hassib
BACKGROUND: Lupus nephritis (LN) is one of the major complications associated with Systemic Lupus Erythematosus (SLE). Activated leukocyte cell adhesion molecule (ALCAM or CD166) is a promising urine biomarker that binds to CD6, a receptor found on lymphocytes. This binding results in T-cell activation, proliferation, and recruitment, which causes tissue inflammation and may explain the pathophysiology of LN. AIM OF WORK: Investigate the urinary ALCAM level in SLE, study its relationship to disease activity, and clarify the association with LN activity and histopathology...
January 31, 2024: Clinical Rheumatology
https://read.qxmd.com/read/38290829/single-cell-profiling-reveals-kidney-cd163-dendritic-cell-participation-in-human-lupus-nephritis
#18
JOURNAL ARTICLE
Wei Chen, Bei Jin, Cheng Cheng, Huajing Peng, Xinxin Zhang, Weiping Tan, Ruihan Tang, Xingji Lian, Hui Diao, Ning Luo, Xiaoyan Li, Jinjin Fan, Jian Shi, Changjun Yin, Ji Wang, Sui Peng, Li Yu, Jun Li, Rui-Qi Wu, Dong-Ming Kuang, Guo-Ping Shi, Yi Zhou, Fang Wang, Xiaoyun Jiang
OBJECTIVES: The current work aimed to provide a comprehensive single-cell landscape of lupus nephritis (LN) kidneys, including immune and non-immune cells, identify disease-associated cell populations and unravel their participation within the kidney microenvironment. METHODS: Single-cell RNA and T cell receptor sequencing were performed on renal biopsy tissues from 40 patients with LN and 6 healthy donors as controls. Matched peripheral blood samples from seven LN patients were also sequenced...
January 30, 2024: Annals of the Rheumatic Diseases
https://read.qxmd.com/read/38270299/cordyceps-cicadae-ameliorates-inflammatory-responses-oxidative-stress-and-fibrosis-by-targeting-the-pi3k-mtor-mediated-autophagy-pathway-in-the-renal-of-mrl-lpr-mice
#19
JOURNAL ARTICLE
Feng Yang, Yanyan Zhang, Lei Dong, Zhichao Song
BACKGROUND: The vast majority of systemic lupus erythematosus patients develop lupus nephritis (LN) with severe renal manifestations, such as inflammatory responses, oxidative stress, and fibrosis. The purpose of this research was to investigate Cordyceps cicadae as a potential therapeutic target for treating inflammatory responses, oxidative stress, and fibrosis in LN. METHODS: The effects of C. cicadae on lupus symptoms in mice with LN were determined...
January 2024: Immunity, Inflammation and Disease
https://read.qxmd.com/read/38267800/rationale-and-design-of-the-japanese-biomarkers-in-nephrotic-syndrome-j-marine-study
#20
JOURNAL ARTICLE
Shimon Kurasawa, Sawako Kato, Takaya Ozeki, Shin'ichi Akiyama, Takuji Ishimoto, Masashi Mizuno, Naotake Tsuboi, Noritoshi Kato, Tomoki Kosugi, Shoichi Maruyama
INTRODUCTION: Disease subtyping and monitoring are essential for the management of nephrotic syndrome (NS). Although various biomarkers for NS have been reported, their clinical efficacy has not been comprehensively validated in adult Japanese patients. METHODS: The Japanese Biomarkers in Nephrotic Syndrome (J-MARINE) study is a nationwide, multicenter, and prospective cohort study in Japan, enrolling adult (≥18 years) patients with minimal change disease (MCD), focal segmental glomerulosclerosis (FSGS), membranous nephropathy (MN), membranoproliferative glomerulonephritis (MPGN), C3 glomerulopathy (C3G), and lupus nephritis (LN)...
January 25, 2024: Clinical and Experimental Nephrology
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